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CY1108602T1 - Μεθοδος καθαρισμου της fsh - Google Patents

Μεθοδος καθαρισμου της fsh

Info

Publication number
CY1108602T1
CY1108602T1 CY20081101371T CY081101371T CY1108602T1 CY 1108602 T1 CY1108602 T1 CY 1108602T1 CY 20081101371 T CY20081101371 T CY 20081101371T CY 081101371 T CY081101371 T CY 081101371T CY 1108602 T1 CY1108602 T1 CY 1108602T1
Authority
CY
Cyprus
Prior art keywords
fsh
cleaning method
chromatography
dye
steps
Prior art date
Application number
CY20081101371T
Other languages
English (en)
Inventor
Pascal Valax
Pierre Wenger
Anne Stanley
Lydia Delegrange
Luciano Capponi
Original Assignee
Ares Trading S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading S.A. filed Critical Ares Trading S.A.
Publication of CY1108602T1 publication Critical patent/CY1108602T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pregnancy & Childbirth (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Fluid-Pressure Circuits (AREA)
  • Fats And Perfumes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Manufacturing Of Electric Cables (AREA)
  • Detergent Compositions (AREA)

Abstract

Η εφεύρεση αναφέρεται σε μία μέθοδο καθαρισμού της ανθρώπινης ανασυνδυασμένης FSH ή μιας παραλλαγής της FSH, ξεκινώντας από την ακατέργαστη FSH, η οποία περιλαμβάνει τα ακόλουθα στάδια: 1. χρωματογραφία συγγένειας βαφής, 2. χρωματογραφία υδρόφοβης αλληλεπίδρασης, και 3. χρωματογραφία αντίστροφης φάσης.
CY20081101371T 2004-11-09 2008-11-27 Μεθοδος καθαρισμου της fsh CY1108602T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04105639 2004-11-09
US62871704P 2004-11-17 2004-11-17
EP05815953A EP1809663B1 (en) 2004-11-09 2005-11-08 Method for purifying fsh

Publications (1)

Publication Number Publication Date
CY1108602T1 true CY1108602T1 (el) 2014-04-09

Family

ID=39560952

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101371T CY1108602T1 (el) 2004-11-09 2008-11-27 Μεθοδος καθαρισμου της fsh

Country Status (22)

Country Link
US (1) US7741455B2 (el)
EP (1) EP1809663B1 (el)
KR (1) KR101173717B1 (el)
CN (1) CN101087805B (el)
AT (1) ATE408624T1 (el)
AU (1) AU2005303818B2 (el)
BR (1) BRPI0517973B8 (el)
CA (1) CA2579131A1 (el)
CY (1) CY1108602T1 (el)
DE (1) DE602005009856D1 (el)
DK (1) DK1809663T3 (el)
EA (1) EA011673B1 (el)
ES (1) ES2312037T3 (el)
HK (1) HK1108704A1 (el)
HR (1) HRP20080464T3 (el)
IL (1) IL182716A (el)
MX (1) MX2007005327A (el)
NO (1) NO340811B1 (el)
PL (1) PL1809663T3 (el)
PT (1) PT1809663E (el)
SI (1) SI1809663T1 (el)
WO (1) WO2006051070A1 (el)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA90664C2 (ru) * 2003-12-22 2010-05-25 Ейрес Трейдінг С.А. Способ очистки fsh
MX2008002596A (es) 2005-08-26 2008-03-14 Ares Trading Sa Proceso para la preparacion de interferon beta glicosilado.
CA2625978A1 (en) * 2005-12-09 2007-06-14 Ares Trading S.A. Method for purifying fsh or a fsh mutant
US9091695B2 (en) * 2007-06-01 2015-07-28 Laboratory Corporation Of America Holdings Methods and systems for quantification of peptides and other analytes
PT2170942E (pt) 2007-06-28 2013-10-22 Biogenerix Ag Clone celular produtor de fsh
AU2008314687A1 (en) * 2007-10-22 2009-04-30 Merck Serono S.A. Method for purifying Fc-fusion proteins
JP2011500757A (ja) * 2007-10-22 2011-01-06 メルク セローノ ソシエテ アノニム Ｆｃ含有タンパク質の精製方法
ME01337B (me) 2008-02-08 2013-12-20 Biogenerix Ag Tečni preparat fsh
JP2009273427A (ja) 2008-05-16 2009-11-26 Jcr Pharmaceuticals Co Ltd 組換え体ヒトｆｓｈの製造方法
SI2414380T1 (sl) * 2009-04-01 2015-12-31 Ratiopharm Gmbh Postopek za čiščenje rekombinantnega FSH
CN101519445B (zh) * 2009-04-08 2013-03-27 上海天伟生物制药有限公司 一种高比活尿促卵泡刺激素及其制备方法
CN101555279B (zh) * 2009-05-19 2013-03-27 上海天伟生物制药有限公司 一种高纯度尿促卵泡刺激素及其制备方法
CN101928342B (zh) * 2009-06-18 2013-05-08 上海天伟生物制药有限公司 一种高纯度绝经期促性腺素及其制备方法和用途
EP2325194A1 (en) 2009-11-24 2011-05-25 Glycotope GmbH Process for the purification of glycoproteins
JP2011172602A (ja) * 2011-06-15 2011-09-08 Jcr Pharmaceuticals Co Ltd 組換え体ヒトｆｓｈの製造方法
CN103570820B (zh) * 2012-08-06 2015-11-18 齐鲁制药有限公司 一种重组人促卵泡激素的纯化方法
WO2014159813A1 (en) 2013-03-13 2014-10-02 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
JP5750471B2 (ja) * 2013-05-22 2015-07-22 Ｊｃｒファーマ株式会社 組換え体ヒトｆｓｈの製造方法
CN103554269B (zh) * 2013-11-01 2015-02-11 广州联康生物科技有限公司 重组猪促卵泡激素融合蛋白
CN103539860B (zh) * 2013-11-01 2014-12-03 广州优联康医药科技有限公司 一种长效重组人促卵泡激素融合蛋白
CN103539861B (zh) * 2013-11-01 2015-02-18 广州联康生物科技有限公司 长效重组人促卵泡激素融合蛋白
CA2945591A1 (en) 2014-04-18 2015-10-22 Cadila Healthcare Limited Novel purification process of gonadotropin
CN104961821A (zh) * 2014-07-28 2015-10-07 厦门欧瑞捷生物科技有限公司 一种从人尿中提取促性腺激素的方法
WO2016116966A1 (en) * 2015-01-22 2016-07-28 Jcr Pharmaceuticals Co., Ltd. Method for purification of recombinant human alpha-galactosidase a from material containing contaminant host cell proteins
CN105461799A (zh) * 2015-12-31 2016-04-06 哈药集团技术中心 一种重组人促卵泡生成素的纯化方法
CN107698676B (zh) * 2017-11-07 2020-07-14 江西浩然生物医药有限公司 一种高纯度尿促性素的提取制备方法
CN110563832A (zh) * 2019-07-31 2019-12-13 江苏璟泽生物医药有限公司 一种高纯度重组促卵泡刺激素纯化方法
CN110305903B (zh) * 2019-07-31 2021-10-01 江苏璟泽生物医药有限公司 重组人促卵泡激素及其制备方法
CN113372433B (zh) * 2021-03-12 2022-10-11 上海景泽生物技术有限公司 纯化fsh方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
US5665868A (en) 1990-09-14 1997-09-09 Vittal Mallya Scientific Research Foundation Chromatographic agent and its use for the separation or proteins, polypeptides of metals
SE9201073D0 (sv) * 1992-04-03 1992-04-03 Kabi Pharmacia Ab Protein formulation
AU720337B2 (en) * 1995-02-17 2000-05-25 Stichting Dienst Landbouwkundig Onderzoek Production of biologically active recombinant bovine follicle stimulating hormone (REC bFSH) in the baculovirus expression system
AUPN801296A0 (en) 1996-02-12 1996-03-07 Csl Limited Stabilised growth hormone formulation and method of preparation thereof
US6162905A (en) * 1996-11-07 2000-12-19 Ibsa Institut Biochimique S.A. FSH and LH separation and purification process
IT1287138B1 (it) 1996-11-07 1998-08-04 Ibsa Inst Biochimique Sa Procedimento per la separazione e purificazione di fsh e lh
US5990288A (en) * 1997-10-21 1999-11-23 Vitro Diagnostics, Inc. Method for purifying FSH
US6414123B1 (en) * 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
ES2284494T3 (es) * 1999-04-16 2007-11-16 Instituto Massone S.A. Procedimiento para preparar composiciones de gonadotropina.
SI1261622T1 (sl) * 2000-02-22 2007-06-30 Merck Serono Sa Preäśiĺ äśeni rekombinantni hlh s specifiäśno bioaktivnostjo in postopek za njegovo preäśiĺ äśenje
CA2405550A1 (en) * 2000-04-12 2001-10-25 Human Genome Sciences, Inc. Albumin fusion proteins
AU784808B2 (en) * 2001-04-02 2006-06-29 Kedrion Melville Inc. Prion and viral clearance process
UA90664C2 (ru) * 2003-12-22 2010-05-25 Ейрес Трейдінг С.А. Способ очистки fsh
US7598356B2 (en) 2004-07-08 2009-10-06 Board of Regents of the University of Nebraska by and on behalf of the University of Nebraska Medical Center Method for purifying a protein of the cystine-knot superfamily

Also Published As

Publication number Publication date
HRP20080464T3 (en) 2008-10-31
PT1809663E (pt) 2008-10-02
IL182716A0 (en) 2007-07-24
NO20072863L (no) 2007-06-05
EA200701040A1 (ru) 2007-10-26
EP1809663A1 (en) 2007-07-25
AU2005303818A1 (en) 2006-05-18
NO340811B1 (no) 2017-06-19
KR20070083618A (ko) 2007-08-24
KR101173717B1 (ko) 2012-08-13
SI1809663T1 (sl) 2009-02-28
DK1809663T3 (da) 2008-11-17
IL182716A (en) 2010-12-30
CN101087805B (zh) 2012-05-23
PL1809663T3 (pl) 2009-01-30
BRPI0517973B8 (pt) 2021-05-25
ES2312037T3 (es) 2009-02-16
BRPI0517973A (pt) 2008-10-21
US7741455B2 (en) 2010-06-22
EA011673B1 (ru) 2009-04-28
HK1108704A1 (en) 2008-05-16
US20080070832A1 (en) 2008-03-20
AU2005303818B2 (en) 2011-06-23
ATE408624T1 (de) 2008-10-15
BRPI0517973B1 (pt) 2018-02-14
MX2007005327A (es) 2007-08-02
CA2579131A1 (en) 2006-05-18
CN101087805A (zh) 2007-12-12
DE602005009856D1 (de) 2008-10-30
WO2006051070A1 (en) 2006-05-18
EP1809663B1 (en) 2008-09-17

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