[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

CR8189A - Sintesis regioselectiva de cci-779 - Google Patents

Sintesis regioselectiva de cci-779

Info

Publication number
CR8189A
CR8189A CR8189A CR8189A CR8189A CR 8189 A CR8189 A CR 8189A CR 8189 A CR8189 A CR 8189A CR 8189 A CR8189 A CR 8189A CR 8189 A CR8189 A CR 8189A
Authority
CR
Costa Rica
Prior art keywords
cci
element synthesis
regional element
synthesis
regional
Prior art date
Application number
CR8189A
Other languages
English (en)
Inventor
Chew Warren
Cheng Shaw Chia
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR8189A publication Critical patent/CR8189A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

Se describe un metodo para la sintesis regioselectiva de CCI-779 a base de quimica de boronato. Se proporcionan tambien intermediarios nuevos utiles en este metodo.
CR8189A 2003-08-07 2006-01-13 Sintesis regioselectiva de cci-779 CR8189A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49324903P 2003-08-07 2003-08-07

Publications (1)

Publication Number Publication Date
CR8189A true CR8189A (es) 2006-10-04

Family

ID=34193170

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8189A CR8189A (es) 2003-08-07 2006-01-13 Sintesis regioselectiva de cci-779

Country Status (27)

Country Link
US (1) US7153957B2 (es)
EP (1) EP1658295B1 (es)
JP (1) JP4227649B2 (es)
KR (1) KR20060057605A (es)
CN (1) CN1829722B (es)
AR (1) AR045217A1 (es)
AT (1) ATE365169T1 (es)
AU (1) AU2004265267A1 (es)
BR (1) BRPI0412667A (es)
CA (1) CA2532988A1 (es)
CO (1) CO5650251A2 (es)
CR (1) CR8189A (es)
DE (1) DE602004007145T2 (es)
DK (1) DK1658295T3 (es)
EC (1) ECSP066413A (es)
ES (1) ES2287772T3 (es)
HK (1) HK1085482A1 (es)
IL (1) IL173134A0 (es)
MX (1) MXPA06000951A (es)
NO (1) NO20060494L (es)
PL (1) PL1658295T3 (es)
PT (1) PT1658295E (es)
RU (1) RU2339639C2 (es)
TW (1) TW200508241A (es)
UA (1) UA83245C2 (es)
WO (1) WO2005016935A2 (es)
ZA (1) ZA200601055B (es)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002085908A1 (en) 2001-04-24 2002-10-31 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
JP4814520B2 (ja) * 2002-05-15 2011-11-16 エンドサイト，インコーポレイテッド ビタミン−マイトマイシン結合体
EP1553940B1 (en) 2002-07-30 2008-02-13 Wyeth Parenteral formulations containing a rapamycin hydroxyester
EP2517729A3 (en) 2003-01-27 2013-01-02 Endocyte, Inc. Vitamin receptor binding drug delivery conjugates
EP1660081A1 (en) * 2003-09-03 2006-05-31 Wyeth Amorphous rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid and pharmaceutical compositions containing the same
PL1701698T3 (pl) * 2004-01-08 2008-03-31 Wyeth Corp Prasowana bezpośrednio kompozycja farmaceutyczna do podawania doustnego CCI-779
US7202256B2 (en) 2004-04-14 2007-04-10 Wyeth Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779
CA2562952A1 (en) 2004-04-14 2005-11-10 Wyeth Regiospecific synthesis of rapamycin 42-ester derivatives
CN1942478A (zh) 2004-04-14 2007-04-04 惠氏公司 用于制备与二羧酸的纳巴霉素42－酯和fk－506 32－酯的方法，用于纳巴霉素配合物的前体和抗体
WO2005106007A1 (en) * 2004-04-27 2005-11-10 Wyeth Labeling of rapamycin using rapamycin-specific methylases
WO2006012527A1 (en) 2004-07-23 2006-02-02 Endocyte, Inc. Bivalent linkers and conjugates thereof
GT200500216A (es) 2004-08-10 2006-03-02 Derivados de cci-779 y metodos para su preparacion
KR20070070184A (ko) 2004-10-28 2007-07-03 와이어쓰 자궁근종의 치료에 있어서 ｍＴＯＲ 억제제의 용도
MX2007009590A (es) * 2005-02-09 2007-09-12 Wyeth Corp Polimorfo cci-779 y uso del mismo.
MX2007010716A (es) * 2005-03-02 2008-01-16 Wyeth Corp Purificacion de rapamicina.
CA2599580A1 (en) * 2005-03-02 2006-09-08 Wyeth Recovery of cci-779 from mother liquors
US8044200B2 (en) 2005-03-16 2011-10-25 Endocyte, Inc. Synthesis and purification of pteroic acid and conjugates thereof
WO2007022494A2 (en) 2005-08-19 2007-02-22 Endocyte, Inc. Multi-drug ligand conjugates
EP1948240A2 (en) * 2005-08-19 2008-07-30 Endocyte, Inc. Ligand conjugates of vinca alkaloids, analogs and derivatives
EP1942937A1 (en) 2005-11-04 2008-07-16 Wyeth Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272
WO2007056175A2 (en) * 2005-11-04 2007-05-18 Wyeth 41-methoxy isotope labeled rapamycin 42-ester
WO2007067565A1 (en) 2005-12-07 2007-06-14 Wyeth Process for the preparation of purified crystalline cci-779
BRPI0619578A2 (pt) 2005-12-07 2011-10-04 Wyeth Corp processo para preparar um 42-éster de rapamicina, composto, método para isolar o boronato do 42-éster de rapamicina bruto a partir do licor mãe, método para purificação de um boronato do 42-éster de rapamicina, e, boronato de cci-779
AU2006322030A1 (en) * 2005-12-07 2007-06-14 Wyeth Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry
BRPI0620213A2 (pt) * 2005-12-20 2011-11-01 Wyeth Corp método para preparar uma composição de rapamicina tendo potência aumentada.
US20070203169A1 (en) * 2006-02-28 2007-08-30 Zhao Jonathon Z Isomers and 42-epimers of rapamycin ester analogs, methods of making and using the same
TW200824713A (en) * 2006-10-18 2008-06-16 Wyeth Corp Processes for the synthesis of individual isomers of mono-PEG CCI-779
US8430055B2 (en) 2008-08-29 2013-04-30 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414909B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US20100104626A1 (en) * 2007-02-16 2010-04-29 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
NZ580132A (en) * 2007-03-14 2012-11-30 Endocyte Inc Binding ligand linked drug delivery conjugates of tubulysins to vitamins
TW200845960A (en) * 2007-04-05 2008-12-01 Wyeth Corp Wortmannin-rapalog conjugate and uses thereof
TW200901989A (en) * 2007-04-10 2009-01-16 Wyeth Corp Anti-tumor activity of CCI-779 in papillary renal cell cancer
EP3569251A1 (en) 2007-06-25 2019-11-20 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
EP2209374B1 (en) 2007-10-25 2014-12-03 Endocyte, Inc. Tubulysins and processes for preparing
EP2480557A2 (en) 2009-09-25 2012-08-01 Cadila Healthcare Limited Process for the preparation of rapamycin derivatives
AU2011210227A1 (en) * 2010-01-28 2012-08-30 Fresenius Kabi Oncology Ltd. Process for the preparation of Temsirolimus and its intermediates
CN102020661B (zh) * 2011-01-07 2013-02-13 天津市炜杰科技有限公司 一种驮瑞塞尔合成方法
CN102020662B (zh) 2011-01-07 2013-02-13 天津市炜杰科技有限公司 一种驮瑞塞尔制备方法
CN103517911B (zh) * 2011-04-01 2016-08-17 桑多斯股份公司 雷帕霉素在c-42位上的区域选择性酰化
WO2013126797A1 (en) 2012-02-24 2013-08-29 Purdue Research Foundation Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
KR20150070318A (ko) 2012-10-16 2015-06-24 엔도사이트, 인코포레이티드 비천연 아미노산을 함유하는 약물 전달 컨쥬게이트 및 사용 방법
CN104086564B (zh) * 2014-07-30 2019-02-05 江苏奥赛康药业股份有限公司 一种高纯度坦罗莫司的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
DE19857765A1 (de) * 1998-12-15 2000-06-21 Clariant Gmbh Verfahren zur Herstellung von para-Oxadiazolyl-phenyl-boronsäuren
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives

Also Published As

Publication number Publication date
US7153957B2 (en) 2006-12-26
EP1658295B1 (en) 2007-06-20
US20050033046A1 (en) 2005-02-10
AR045217A1 (es) 2005-10-19
BRPI0412667A (pt) 2006-09-26
RU2339639C2 (ru) 2008-11-27
JP4227649B2 (ja) 2009-02-18
KR20060057605A (ko) 2006-05-26
ES2287772T3 (es) 2007-12-16
DE602004007145D1 (de) 2007-08-02
UA83245C2 (en) 2008-06-25
WO2005016935A3 (en) 2005-04-07
JP2007501783A (ja) 2007-02-01
DE602004007145T2 (de) 2008-02-28
ZA200601055B (en) 2008-07-30
CN1829722B (zh) 2010-10-27
CA2532988A1 (en) 2005-02-24
EP1658295A2 (en) 2006-05-24
ATE365169T1 (de) 2007-07-15
MXPA06000951A (es) 2006-03-30
CO5650251A2 (es) 2006-06-30
PT1658295E (pt) 2007-09-25
CN1829722A (zh) 2006-09-06
HK1085482A1 (en) 2006-08-25
PL1658295T3 (pl) 2007-11-30
TW200508241A (en) 2005-03-01
RU2006106910A (ru) 2007-09-20
AU2004265267A1 (en) 2005-02-24
NO20060494L (no) 2006-03-06
WO2005016935A2 (en) 2005-02-24
DK1658295T3 (da) 2007-09-24
IL173134A0 (en) 2006-06-11
ECSP066413A (es) 2006-09-18

Similar Documents

Publication Publication Date Title
CR8189A (es) Sintesis regioselectiva de cci-779
ATE298778T1 (de) Fischer-tropsch-syntheseverfahren
ATE490253T1 (de) Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen
DE60307862D1 (de) Positioniervorrichtung für nägel
DE60328138D1 (de) Zwischenprodukte für die Herstellung von Dioxan-2-alkylcarbamaten
DE602004029014D1 (de) Ambossplatte für heftvorrichtung
DE50300979D1 (de) Verwendung von Makromonomeren für die Herstellung von Acrylathaftklebemassen
ES1053304Y (es) Disposicion mejorada para la fijacion de fregaderos.
DE60216885D1 (de) Prozessor für die Befehlszeilenschnittstelle
ITMI20041770A1 (it) "procedimento per il funzionamento di un motore endotermico"
DE60332980D1 (de) Sprachsynthese
ITMI20040481A1 (it) Dispositivo per il montaggio scorrevole di pezzi
DE602004016116D1 (de) Wachszusammensetzung für die bauplattenanwendung
DE60303424D1 (de) D-Ring Halterung
DE50308029D1 (de) Kontrastmittel für die lymphknoten-darstellung
ITMI20030352A1 (it) Metodo per la sintesi di metiltriossorenio.
ITBO20020156A0 (it) Allestimento di un furgone isotermico facilmente smontabile
UA9614S (uk) Календар відривний
ES1050717Y (es) Soporte para bandejas portacables-
IT249683Y1 (it) Dispositivo per il posizionamento di gruppi di taglio
ITMI20030285A1 (it) Box doccia abbrozzante
DE10190811D2 (de) Auflageschlitten für Frässchablonen
FIU20020464U0 (fi) Tuppiliippa
ES1051089Y (es) Soporte para cajon de persiana
UY26642A1 (es) Proceso para la n-formulación selectiva de n-hidroxilaminas

Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)