CO7400872A2 - Derivados sustituidos de ftalazin-1(2h)-ona - Google Patents
Derivados sustituidos de ftalazin-1(2h)-onaInfo
- Publication number
- CO7400872A2 CO7400872A2 CO15127891A CO15127891A CO7400872A2 CO 7400872 A2 CO7400872 A2 CO 7400872A2 CO 15127891 A CO15127891 A CO 15127891A CO 15127891 A CO15127891 A CO 15127891A CO 7400872 A2 CO7400872 A2 CO 7400872A2
- Authority
- CO
- Colombia
- Prior art keywords
- pharmaceutically acceptable
- new
- compounds
- phthalazin
- substituted derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a nuevos compuestos de fórmula general (I), susestereoisómeros, regioisómeros, formas tautómeras y nuevos compuestos intermediariosque intervienen en su síntesis, sus sales farmacéuticamente aceptables, solvatosfarmacéuticamente aceptables y composiciones farmacéuticas que los contienen. Lapresente invención también se refiere a un proceso de preparación de nuevos compuestosde fórmula general (I), sus estereoisómeros, regioisómeros, sus formas tautoméricas, sussales farmacéuticamente aceptables, solvatos farmacéuticamente aceptables, composicionesfarmacéuticas que los contienen, y nuevos compuestos intermediarios que intervienen en susíntesis
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3742MU2012 | 2012-12-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO7400872A2 true CO7400872A2 (es) | 2015-09-30 |
Family
ID=54198806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO15127891A CO7400872A2 (es) | 2012-12-31 | 2015-06-03 | Derivados sustituidos de ftalazin-1(2h)-ona |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US9598418B2 (es) |
| EP (1) | EP2938598B1 (es) |
| JP (1) | JP5930452B2 (es) |
| KR (1) | KR101652654B1 (es) |
| CN (1) | CN104918917A (es) |
| AP (1) | AP2015008439A0 (es) |
| AR (1) | AR094299A1 (es) |
| AU (1) | AU2013368842B2 (es) |
| BR (1) | BR112015012425A2 (es) |
| CA (1) | CA2890309A1 (es) |
| CL (1) | CL2015001655A1 (es) |
| CO (1) | CO7400872A2 (es) |
| DK (1) | DK2938598T3 (es) |
| EA (1) | EA201591239A1 (es) |
| ES (1) | ES2614885T3 (es) |
| GE (1) | GEP201706691B (es) |
| HK (1) | HK1210466A1 (es) |
| HR (1) | HRP20170219T1 (es) |
| HU (1) | HUE030613T2 (es) |
| IL (1) | IL238714A0 (es) |
| MA (1) | MA38080A1 (es) |
| MX (1) | MX2015006780A (es) |
| NZ (1) | NZ708255A (es) |
| PH (1) | PH12015501199B1 (es) |
| PL (1) | PL2938598T3 (es) |
| PT (1) | PT2938598T (es) |
| SG (1) | SG11201503670YA (es) |
| TW (1) | TWI553005B (es) |
| WO (1) | WO2014102817A1 (es) |
| ZA (1) | ZA201503218B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| RS56776B1 (sr) | 2013-11-26 | 2018-04-30 | Hoffmann La Roche | Derivati oktahidro-ciklobuta [1,2-c;3,4-c']dipirola kao inhibitori autotaksina |
| EA037928B1 (ru) | 2014-03-26 | 2021-06-08 | Ф. Хоффманн-Ля Рош Аг | Бициклические соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
| WO2016187620A2 (en) | 2015-05-21 | 2016-11-24 | The Regents Of The University Of California | Anti-cancer compounds |
| CA2992889A1 (en) | 2015-09-04 | 2017-03-09 | F. Hoffmann-La Roche Ag | Phenoxymethyl derivatives |
| RU2018114289A (ru) | 2015-09-24 | 2019-10-24 | Ф. Хоффманн-Ля Рош Аг | Бициклические соединения в качестве ингибиторов аутотаксина (atx) |
| BR112017026682A2 (pt) | 2015-09-24 | 2018-08-14 | Hoffmann La Roche | novos compostos bicíclicos como inibidores de dupla ação de atx/ca |
| WO2017050792A1 (en) * | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| JP6877413B2 (ja) * | 2015-09-24 | 2021-05-26 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 二重ａｔｘ／ｃａ阻害剤としての新規な二環式化合物 |
| WO2017071636A1 (zh) * | 2015-10-30 | 2017-05-04 | 四川科伦博泰生物医药股份有限公司 | 酞嗪酮衍生物、其制备方法及用途 |
| WO2017101796A1 (zh) * | 2015-12-16 | 2017-06-22 | 四川科伦博泰生物医药股份有限公司 | 酞嗪酮衍生物、其制备方法及用途 |
| WO2017223516A1 (en) | 2016-06-24 | 2017-12-28 | The Regents Of The University Of California | Phthalazine derivatives as inhibitors of parp1, parp2 and/or tubulin useful for the treatment of cancer |
| BR112019019017A2 (pt) | 2017-03-16 | 2020-04-14 | Hoffmann La Roche | compostos heterocíclicos de utilidade como inibidores duplos de atx/ca |
| JP7090099B2 (ja) | 2017-03-16 | 2022-06-23 | エフ．ホフマン－ラ ロシュ アーゲー | Ａｔｘインヒビターとしての新規二環式化合物 |
| ES2747768T3 (es) | 2017-03-20 | 2020-03-11 | Forma Therapeutics Inc | Composiciones de pirrolopirrol como activadores de quinasa de piruvato (PKR) |
| CN109251204A (zh) * | 2017-07-13 | 2019-01-22 | 中国药科大学 | 含有酞嗪-1(2h)-酮结构的parp抑制剂、其制法及医药用途 |
| CN108164468B (zh) * | 2018-02-09 | 2021-02-02 | 上海卫岑医药科技有限公司 | 一种parp抑制剂、其药物组合物、制备方法及应用 |
| CN113166060B (zh) | 2018-09-19 | 2024-01-09 | 诺沃挪第克健康护理股份公司 | 用丙酮酸激酶激活化合物治疗镰状细胞病 |
| CN113226356A (zh) | 2018-09-19 | 2021-08-06 | 福马治疗股份有限公司 | 活化丙酮酸激酶r |
| EP4148046A4 (en) * | 2020-05-08 | 2024-07-24 | Txinno Bioscience Inc | NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE INHIBITION ACTIVITY, AND USE THEREOF |
| WO2022192745A1 (en) * | 2021-03-11 | 2022-09-15 | Mirati Therapeutics, Inc. | Mta-cooperative prmt5 inhibitors |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| US20240317762A1 (en) * | 2021-07-16 | 2024-09-26 | Oregon Health & Science University | Phthalazinone-based parp-1 inhibitors |
| CN118871432A (zh) * | 2022-03-15 | 2024-10-29 | 百济神州有限公司 | 作为prmt5的mta协同抑制剂的4-(氨基甲基)-6-(1-甲基-1h-吡唑-4-基)异喹啉-1(2h)-酮衍生物 |
| WO2024046420A1 (zh) * | 2022-08-31 | 2024-03-07 | 江苏恒瑞医药股份有限公司 | 稠合二环类化合物、其制备方法及其在医药上的应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6531464B1 (en) | 1999-12-07 | 2003-03-11 | Inotek Pharmaceutical Corporation | Methods for the treatment of neurodegenerative disorders using substituted phenanthridinone derivatives |
| CN100400518C (zh) | 2000-10-30 | 2008-07-09 | 库多斯药物有限公司 | 2,3-二氮杂萘酮衍生物 |
| US7449464B2 (en) * | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| EA009469B1 (ru) | 2003-03-12 | 2007-12-28 | Кудос Фармасеутикалс Лимитед | Производные фталазинона |
| WO2005066163A2 (en) | 2004-01-05 | 2005-07-21 | Astrazeneca Ab | Thiophene derivatives as chk 1 inihibitors |
| MX2007002318A (es) | 2004-08-26 | 2007-04-17 | Kudos Pharm Ltd | Derivados de ftalazinona substituidos con 4-heteroarilmetilo. |
| US20060079510A1 (en) | 2004-09-30 | 2006-04-13 | Kristoffer Hellstrand | Use of PARP-1 inhibitors for protecting tumorcidal lymphocytes from apoptosis |
| MX2007012448A (es) | 2005-04-06 | 2007-10-19 | Astrazeneca Ab | Heterociclos sustituidos y su uso como inhibidores de chk1, pdk1 y pak. |
| DE602006020335D1 (de) | 2005-11-25 | 2011-04-07 | Pharma Mar Sa | Verwendung von parp-1-hemmern |
| GB0610680D0 (en) * | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
| TWI404716B (zh) | 2006-10-17 | 2013-08-11 | Kudos Pharm Ltd | 酞嗪酮（ｐｈｔｈａｌａｚｉｎｏｎｅ）衍生物 |
| US8466150B2 (en) * | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
| HUE027641T2 (en) | 2006-12-28 | 2016-11-28 | Abbvie Inc | Poly (ADP-ribose) polymerase inhibitors |
| CA2687786A1 (en) | 2007-05-25 | 2008-12-04 | Astrazenca Ab | Combination of chk and parp inhibitors for the treatment of cancers |
| US20090023727A1 (en) * | 2007-07-05 | 2009-01-22 | Muhammad Hashim Javaid | Phthalazinone derivatives |
| EP2220073B1 (en) | 2007-11-15 | 2014-09-03 | MSD Italia S.r.l. | Pyridazinone derivatives as parp inhibitors |
| UY31603A1 (es) | 2008-01-23 | 2009-08-31 | Derivados de ftalazinona | |
| MY160340A (en) | 2008-10-07 | 2017-02-28 | Astrazeneca Uk Ltd | Pharmaceutical formulation 514 |
| JP2013532683A (ja) | 2010-07-27 | 2013-08-19 | カディラ ヘルスケア リミティド | ポリ（ａｄｐリボース）ポリメラーゼ−１阻害剤としての、置換４−（４−フルオロ−３−（ピペラジン−１−カルボニル）ベンジル）フタラジン−１（２ｈ）−オン誘導体 |
| CN102372706A (zh) * | 2010-08-09 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 酞嗪酮类衍生物、其制备方法及其在医药上的应用 |
| CN102372716A (zh) * | 2010-08-09 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 酞嗪酮类衍生物、其制备方法及其在医药上的应用 |
| CN102372698A (zh) * | 2010-08-10 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 酞嗪酮类衍生物、其制备方法及其在医药上的应用 |
| US8999985B2 (en) * | 2010-12-02 | 2015-04-07 | Shanghai De Novo Pharmatech Co Ltd. | Substituted phthalazin-1(2H)-ones, preparation processes and medical uses thereof |
| CN102485721B (zh) | 2010-12-03 | 2015-12-09 | 曹亚 | 取代的2,3-二氮杂萘酮化合物及其用途 |
| CN103717609B (zh) | 2011-05-31 | 2016-05-11 | 江苏康缘药业股份有限公司 | 聚(adp-核糖)聚合酶的三环抑制剂 |
| JP5927071B2 (ja) | 2011-07-13 | 2016-05-25 | 参天製薬株式会社 | Ｐａｒｐ阻害活性を有する新規化合物 |
| US20130053365A1 (en) | 2011-08-30 | 2013-02-28 | Biomarin Pharmaceutical, Inc. | Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp) |
| WO2013097226A1 (en) | 2011-12-31 | 2013-07-04 | Beigene, Ltd. | Fused tetra or penta-cyclic pyridophthalazinones as parp inhibitors |
| EA026611B1 (ru) | 2012-02-09 | 2017-04-28 | Мерк Патент Гмбх | Производные тетрагидрохиназолинона в качестве ингибиторов tank и parp |
| CN103242273B (zh) | 2012-02-09 | 2015-06-03 | 中国科学院上海药物研究所 | 2-芳基苯并呋喃-7-甲酰胺类化合物、其制备方法及用途 |
-
2013
- 2013-12-23 US US14/647,088 patent/US9598418B2/en not_active Expired - Fee Related
- 2013-12-23 DK DK13828996.2T patent/DK2938598T3/en active
- 2013-12-23 NZ NZ708255A patent/NZ708255A/en not_active IP Right Cessation
- 2013-12-23 PT PT138289962T patent/PT2938598T/pt unknown
- 2013-12-23 AP AP2015008439A patent/AP2015008439A0/xx unknown
- 2013-12-23 KR KR1020157017355A patent/KR101652654B1/ko active IP Right Grant
- 2013-12-23 SG SG11201503670YA patent/SG11201503670YA/en unknown
- 2013-12-23 HU HUE13828996A patent/HUE030613T2/en unknown
- 2013-12-23 MA MA38080A patent/MA38080A1/fr unknown
- 2013-12-23 WO PCT/IN2013/000794 patent/WO2014102817A1/en active Application Filing
- 2013-12-23 EP EP13828996.2A patent/EP2938598B1/en not_active Not-in-force
- 2013-12-23 PL PL13828996T patent/PL2938598T3/pl unknown
- 2013-12-23 CA CA2890309A patent/CA2890309A1/en not_active Abandoned
- 2013-12-23 EA EA201591239A patent/EA201591239A1/ru unknown
- 2013-12-23 AU AU2013368842A patent/AU2013368842B2/en not_active Ceased
- 2013-12-23 BR BR112015012425A patent/BR112015012425A2/pt not_active IP Right Cessation
- 2013-12-23 MX MX2015006780A patent/MX2015006780A/es unknown
- 2013-12-23 JP JP2015550210A patent/JP5930452B2/ja not_active Expired - Fee Related
- 2013-12-23 CN CN201380069025.0A patent/CN104918917A/zh active Pending
- 2013-12-23 ES ES13828996.2T patent/ES2614885T3/es active Active
- 2013-12-23 GE GEAP201313901A patent/GEP201706691B/en unknown
- 2013-12-26 TW TW102148473A patent/TWI553005B/zh not_active IP Right Cessation
- 2013-12-27 AR ARP130105054A patent/AR094299A1/es unknown
-
2015
- 2015-05-08 ZA ZA2015/03218A patent/ZA201503218B/en unknown
- 2015-05-10 IL IL238714A patent/IL238714A0/en not_active IP Right Cessation
- 2015-05-28 PH PH12015501199A patent/PH12015501199B1/en unknown
- 2015-06-03 CO CO15127891A patent/CO7400872A2/es unknown
- 2015-06-12 CL CL2015001655A patent/CL2015001655A1/es unknown
- 2015-11-13 HK HK15111208.8A patent/HK1210466A1/xx not_active IP Right Cessation
-
2017
- 2017-02-09 HR HRP20170219TT patent/HRP20170219T1/hr unknown
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