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CO7151487A2 - Formulación de anticuerpos - Google Patents

Formulación de anticuerpos

Info

Publication number
CO7151487A2
CO7151487A2 CO14278419A CO14278419A CO7151487A2 CO 7151487 A2 CO7151487 A2 CO 7151487A2 CO 14278419 A CO14278419 A CO 14278419A CO 14278419 A CO14278419 A CO 14278419A CO 7151487 A2 CO7151487 A2 CO 7151487A2
Authority
CO
Colombia
Prior art keywords
antibody formulation
antibody
sugars
formulated
surfactant
Prior art date
Application number
CO14278419A
Other languages
English (en)
Inventor
Marta Cosenza
Christoph Stark
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48914378&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO7151487(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO7151487A2 publication Critical patent/CO7151487A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Los anticuerpos anti-BAFFR se formulan como formulación líquida que comprende una alta concentración del ingrediente activo de anticuerpo para la entrega en un paciente sin altos niveles de agregación de anticuerpos. La composición farmacéutica acuosa puede incluir uno o más azúcares, un agente amortiguador, un surfactante, y/o un aminoácido libre.
CO14278419A 2012-06-12 2014-12-18 Formulación de anticuerpos CO7151487A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261658472P 2012-06-12 2012-06-12

Publications (1)

Publication Number Publication Date
CO7151487A2 true CO7151487A2 (es) 2014-12-29

Family

ID=48914378

Family Applications (1)

Application Number Title Priority Date Filing Date
CO14278419A CO7151487A2 (es) 2012-06-12 2014-12-18 Formulación de anticuerpos

Country Status (36)

Country Link
US (4) US9216219B2 (es)
EP (2) EP2858671B1 (es)
JP (1) JP6265978B2 (es)
KR (1) KR102124820B1 (es)
CN (1) CN104363920B (es)
AR (1) AR091413A1 (es)
AU (1) AU2013276112B2 (es)
BR (1) BR112014030820B1 (es)
CA (1) CA2875386C (es)
CL (1) CL2014003370A1 (es)
CO (1) CO7151487A2 (es)
CY (1) CY1122181T1 (es)
DK (1) DK2858671T3 (es)
EA (1) EA033373B1 (es)
EC (1) ECSP15017314A (es)
ES (1) ES2751659T3 (es)
GT (1) GT201400285A (es)
HK (1) HK1203146A1 (es)
HR (1) HRP20191827T1 (es)
HU (1) HUE045523T2 (es)
IL (1) IL235966B (es)
LT (1) LT2858671T (es)
MA (1) MA37616A1 (es)
MX (1) MX363380B (es)
MY (1) MY179818A (es)
NZ (1) NZ630885A (es)
PE (1) PE20150200A1 (es)
PH (1) PH12014502778B1 (es)
PL (1) PL2858671T3 (es)
PT (1) PT2858671T (es)
SG (1) SG11201408174UA (es)
SI (1) SI2858671T1 (es)
TN (1) TN2014000488A1 (es)
TW (1) TWI653983B (es)
WO (1) WO2013186700A1 (es)
ZA (1) ZA201408547B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3459564T3 (da) 2010-01-06 2022-02-07 Takeda Pharmaceuticals Co Plasmakallikreinbindende proteiner
WO2012076670A2 (en) * 2010-12-10 2012-06-14 Novartis Ag Antibody formulation
KR102502293B1 (ko) 2011-01-06 2023-02-21 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
US9216219B2 (en) 2012-06-12 2015-12-22 Novartis Ag Anti-BAFFR antibody formulation
TWI595007B (zh) 2012-09-10 2017-08-11 Neotope Biosciences Ltd 抗ｍｃａｍ抗體及相關使用方法
IL292121B2 (en) 2013-03-15 2024-02-01 Takeda Pharmaceuticals Co Anti-plasma kallikrein antibodies
US10513555B2 (en) * 2013-07-04 2019-12-24 Prothena Biosciences Limited Antibody formulations and methods
CN104730237A (zh) * 2013-12-23 2015-06-24 国家纳米科学中心 试纸及其应用以及检测甲胎蛋白抗原、乙肝表面抗原或HIV的gp41抗体的方法
KR20160131073A (ko) 2014-03-12 2016-11-15 프로테나 바이오사이언시즈 리미티드 Lg4-5에 대해 특이적인 항-라미닌4 항체
US10407506B2 (en) 2014-03-12 2019-09-10 Prothena Biosciences Limited Anti-MCAM antibodies and associated methods of use
CN106459210A (zh) 2014-03-27 2017-02-22 戴埃克斯有限公司 用于治疗糖尿病黄斑性水肿的组合物和方法
KR101597037B1 (ko) 2014-06-26 2016-02-24 엘지디스플레이 주식회사 구동소자의 전기적 특성 편차를 보상할 수 있는 유기발광 표시장치
TWI705827B (zh) 2014-11-07 2020-10-01 瑞士商諾華公司 治療眼部疾病之方法
US10464999B2 (en) 2015-01-28 2019-11-05 Prothena Biosciences Limited Anti-transthyretin antibodies
MX2017012423A (es) * 2015-03-30 2018-01-26 Dyax Corp Inhibidores de calicreina plasmatica y uso de los mismos para prevenir el ataque del angioedema hereditario.
WO2017046776A2 (en) * 2015-09-16 2017-03-23 Prothena Biosciences Limited Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis
CA3007481C (en) * 2015-12-07 2024-01-30 Merck Patent Gmbh Aqueous pharmaceutical formulation comprising anti-pd-l1 antibody avelumab
IL259691B2 (en) 2015-12-11 2024-08-01 Dyax Corp Plasma kallikrein inhibitors and their uses in the treatment of hereditary angioedema attack
CA3008779A1 (en) * 2015-12-18 2017-06-22 Astellas Pharma Inc. Pharmaceutical composition comprising anti-human tslp receptor antibody
JP6595132B2 (ja) * 2016-06-16 2019-10-23 ヤンセン ファッシンズ アンド プリベンション ベーフェー Ｈｉｖワクチン製剤
JP7261158B2 (ja) 2016-10-19 2023-04-19 インベンラ， インコーポレイテッド 抗体構築物
WO2018115485A1 (en) 2016-12-22 2018-06-28 Pierfrancesco Tassone A monoclonal antibody targeting a unique sialoglycosilated cancer-associated epitope of cd43
EP3797792A1 (en) * 2017-03-01 2021-03-31 MedImmune Limited Formulations of anti-gm-csfralpha monoclonal antibody
SG11201908091QA (en) * 2017-03-06 2019-10-30 Merck Patent Gmbh Aqueous anti-pd-l1 antibody formulation
WO2018193471A1 (en) * 2017-04-18 2018-10-25 Dr. Reddy's Laboratories Limited Stable liquid pharmaceutical composition
KR20230066126A (ko) 2017-07-27 2023-05-12 알렉시온 파마슈티칼스, 인코포레이티드 고농도 항-c5 항체 제형
PT3672631T (pt) * 2017-08-22 2023-05-23 Biogen Ma Inc Composições farmacêuticas contendo anticorpos anti-betaamiloide
PE20211453A1 (es) * 2017-11-29 2021-08-05 Prothena Biosciences Ltd Formulacion liofilizada de un anticuerpo monoclonal contra transtirretina
WO2019234136A1 (en) 2018-06-05 2019-12-12 King's College London Btnl3/8 targeting constructs for delivery of payloads to the gastrointestinal system
BR112021011290A2 (pt) * 2018-12-18 2021-11-03 Novartis Ag Formulação de solução de proteína contendo alta concentração de um anticorpo anti-vegf
MA55033A (fr) 2019-02-18 2021-12-29 Lilly Co Eli Formulation d'anticorps thérapeutique
KR20210134926A (ko) * 2019-02-26 2021-11-11 이노벤트 바이오로직스 (쑤저우) 컴퍼니, 리미티드 항-cd47 항체를 포함하는 제제, 이의 제조 방법 및 이의 용도
AU2020377872A1 (en) 2019-11-06 2022-05-26 Novartis Ag Treatment for Sjogren's Syndrome
WO2021136274A1 (zh) * 2019-12-30 2021-07-08 百奥泰生物制药股份有限公司 含抗Trop2抗体-药物偶联物的制剂及其制备方法和应用
AU2021211799A1 (en) * 2020-01-21 2022-08-11 Innovent Biologics (Suzhou) Co., Ltd. Recombinant fully human anti-TIGIT monoclonal antibody preparations, preparation method therefor and use thereof
AU2021320129A1 (en) 2020-08-04 2023-03-16 Novartis Ag Treatment of B cell malignancies
CN115073598B (zh) * 2021-03-15 2024-02-20 盛禾(中国)生物制药有限公司 一种抗baffr抗体及其应用
KR20240004760A (ko) 2021-05-04 2024-01-11 노파르티스 아게 항-baffr 항체를 사용한 루푸스 신염의 치료
KR20240004761A (ko) 2021-05-04 2024-01-11 노파르티스 아게 항-baffr 항체를 사용한 전신 홍반성 루푸스의 치료
JP2024537772A (ja) * 2021-09-29 2024-10-16 ドラゴンフライ セラピューティクス， インコーポレイテッド Ｂａｆｆ－ｒを標的化する抗体及びその使用
CN118681009A (zh) * 2023-03-21 2024-09-24 百奥泰生物制药股份有限公司 一种复方制剂及其应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0154316B1 (en) 1984-03-06 1989-09-13 Takeda Chemical Industries, Ltd. Chemically modified lymphokine and production thereof
WO1990006952A1 (en) 1988-12-22 1990-06-28 Kirin-Amgen, Inc. Chemically modified granulocyte colony stimulating factor
US20020077461A1 (en) * 1996-04-24 2002-06-20 Soren Bjorn Pharmaceutical formulation
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
ES2340112T3 (es) 1998-04-20 2010-05-28 Glycart Biotechnology Ag Ingenieria de glicosilacion de anticuerpos para la mejora de la citotoxicidad celular dependiente de anticuerpos.
EP2278003B2 (en) 1999-04-09 2020-08-05 Kyowa Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
AU780468B2 (en) 1999-06-23 2005-03-24 Oregon Health And Science University Method for enhancing hematopoiesis
EP1297172B1 (en) 2000-06-28 2005-11-09 Glycofi, Inc. Methods for producing modified glycoproteins
AU2002337935B2 (en) 2001-10-25 2008-05-01 Genentech, Inc. Glycoprotein compositions
JP5290489B2 (ja) 2001-11-08 2013-09-18 アッヴィ・バイオセラピューティクス・インコーポレイテッド Ｉｇｇ抗体の安定な液体医薬製剤
EP3210624A1 (en) 2002-02-27 2017-08-30 Immunex Corporation Stabilized tnfr-fc composition comprising arginine
US20040191243A1 (en) 2002-12-13 2004-09-30 Bei Chen System and method for stabilizing antibodies with histidine
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
EA200701211A1 (ru) * 2004-12-31 2007-12-28 Дженентек, Инк. Полипептиды, которые связываются с br3, и их применение
PL2315780T3 (pl) * 2008-07-17 2016-01-29 Novartis Ag Kompozycje i sposoby zastosowania przeciwciał terapeutycznych
MX2012005195A (es) * 2009-11-17 2012-06-12 Ipsen Pharma Sas Formulacion para combinacion de rgh y rhlgf-1.
WO2012076670A2 (en) 2010-12-10 2012-06-14 Novartis Ag Antibody formulation
EP2788024A1 (en) 2011-12-06 2014-10-15 F.Hoffmann-La Roche Ag Antibody formulation
US9216219B2 (en) 2012-06-12 2015-12-22 Novartis Ag Anti-BAFFR antibody formulation

Also Published As

Publication number Publication date
HUE045523T2 (hu) 2020-01-28
PH12014502778A1 (en) 2015-02-02
EA033373B1 (ru) 2019-10-31
DK2858671T3 (da) 2019-10-21
EP2858671B1 (en) 2019-07-24
IL235966B (en) 2020-05-31
TW201402144A (zh) 2014-01-16
TWI653983B (zh) 2019-03-21
JP2015521593A (ja) 2015-07-30
US9751951B2 (en) 2017-09-05
MY179818A (en) 2020-11-16
KR102124820B1 (ko) 2020-06-22
US20180251564A1 (en) 2018-09-06
BR112014030820A2 (pt) 2017-07-25
WO2013186700A1 (en) 2013-12-19
US20160145341A1 (en) 2016-05-26
EA201492292A1 (ru) 2015-04-30
SI2858671T1 (sl) 2019-11-29
KR20150029683A (ko) 2015-03-18
EP3593814A1 (en) 2020-01-15
AU2013276112A1 (en) 2014-12-18
CA2875386A1 (en) 2013-12-19
CY1122181T1 (el) 2020-11-25
US20130344088A1 (en) 2013-12-26
JP6265978B2 (ja) 2018-01-24
SG11201408174UA (en) 2015-01-29
US10689451B2 (en) 2020-06-23
LT2858671T (lt) 2019-10-25
NZ630885A (en) 2016-01-29
GT201400285A (es) 2015-10-15
HRP20191827T1 (hr) 2019-12-27
ZA201408547B (en) 2015-12-23
MX363380B (es) 2019-03-21
HK1203146A1 (en) 2015-10-23
IL235966A0 (en) 2015-01-29
ECSP15017314A (es) 2018-06-30
MX2014015262A (es) 2015-06-23
CL2014003370A1 (es) 2015-02-06
AU2013276112B2 (en) 2015-07-09
MA37616A1 (fr) 2017-08-31
PL2858671T3 (pl) 2020-01-31
PT2858671T (pt) 2019-10-28
PH12014502778B1 (en) 2015-02-02
PE20150200A1 (es) 2015-02-08
TN2014000488A1 (en) 2016-03-30
US20180051092A1 (en) 2018-02-22
US9216219B2 (en) 2015-12-22
BR112014030820B1 (pt) 2023-02-07
AR091413A1 (es) 2015-02-04
CA2875386C (en) 2022-09-13
CN104363920A (zh) 2015-02-18
CN104363920B (zh) 2018-05-04
ES2751659T3 (es) 2020-04-01
EP2858671A1 (en) 2015-04-15

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