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CO6541606A2 - Espiroindolinona- pirrolidinas - Google Patents

Espiroindolinona- pirrolidinas

Info

Publication number
CO6541606A2
CO6541606A2 CO12086101A CO12086101A CO6541606A2 CO 6541606 A2 CO6541606 A2 CO 6541606A2 CO 12086101 A CO12086101 A CO 12086101A CO 12086101 A CO12086101 A CO 12086101A CO 6541606 A2 CO6541606 A2 CO 6541606A2
Authority
CO
Colombia
Prior art keywords
pirrolidinas
espiroindolinona
compounds
nicancerous
esters
Prior art date
Application number
CO12086101A
Other languages
English (en)
Inventor
David Joseph Bartkovitz
Xin-Jie Chu
Zhuming Zhang
Jing Zhang
Nan Jiang
Bradford James Graves
Qingjie Ding
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO6541606A2 publication Critical patent/CO6541606A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)

Abstract

Se proporcionan compuestos de la fórmula (I)en la que X, Y y de R1 a R8 tienen los significados aquí definidos, junto con, los enantiómeros, las sales y los esteres farmacéuticamente aceptables de los mismos. Estos compuestos son útiles como agentes nticancerosos.
CO12086101A 2009-12-02 2012-05-24 Espiroindolinona- pirrolidinas CO6541606A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26579209P 2009-12-02 2009-12-02
US38805410P 2010-09-30 2010-09-30

Publications (1)

Publication Number Publication Date
CO6541606A2 true CO6541606A2 (es) 2012-10-16

Family

ID=43608656

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12086101A CO6541606A2 (es) 2009-12-02 2012-05-24 Espiroindolinona- pirrolidinas

Country Status (26)

Country Link
US (1) US8088815B2 (es)
EP (1) EP2507243B1 (es)
JP (1) JP5647262B2 (es)
KR (1) KR101418191B1 (es)
CN (1) CN102741257B (es)
AR (1) AR079226A1 (es)
AU (1) AU2010326855B2 (es)
BR (1) BR112012012872A2 (es)
CA (1) CA2781823A1 (es)
CL (1) CL2012001405A1 (es)
CO (1) CO6541606A2 (es)
CR (1) CR20120259A (es)
EC (1) ECSP12011945A (es)
ES (1) ES2543468T3 (es)
HK (1) HK1173720A1 (es)
IL (1) IL220010A (es)
MA (1) MA33976B1 (es)
MX (1) MX2012006260A (es)
MY (1) MY160596A (es)
NZ (1) NZ600024A (es)
PE (1) PE20121334A1 (es)
RU (1) RU2571100C2 (es)
SG (1) SG181465A1 (es)
TW (1) TW201129571A (es)
WO (1) WO2011067185A1 (es)
ZA (1) ZA201204036B (es)

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US20120046306A1 (en) * 2010-08-18 2012-02-23 David Joseph Bartkovitz Substituted Heteroaryl Spiropyrrolidine MDM2 Antagonists
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CN111718354A (zh) 2014-04-17 2020-09-29 密歇根大学董事会 Mdm2抑制剂和使用其的治疗方法
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US10905739B2 (en) 2014-09-24 2021-02-02 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
US10471120B2 (en) 2014-09-24 2019-11-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
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RU2629750C2 (ru) * 2015-04-09 2017-09-01 Ян Андреевич Иваненков НОВЫЕ ДИСПИРО-ИНДОЛИНОНЫ, ИНГИБИТОРЫ MDM2/p53 ВЗАИМОДЕЙСТВИЯ, СПОСОБ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
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Also Published As

Publication number Publication date
TW201129571A (en) 2011-09-01
MA33976B1 (fr) 2013-02-01
KR20120101481A (ko) 2012-09-13
IL220010A (en) 2014-03-31
JP2013512869A (ja) 2013-04-18
MX2012006260A (es) 2012-06-19
MY160596A (en) 2017-03-15
CN102741257A (zh) 2012-10-17
HK1173720A1 (en) 2013-05-24
ZA201204036B (en) 2013-02-27
PE20121334A1 (es) 2012-10-12
RU2571100C2 (ru) 2015-12-20
CN102741257B (zh) 2015-03-04
EP2507243B1 (en) 2015-06-10
ECSP12011945A (es) 2012-07-31
EP2507243A1 (en) 2012-10-10
US20110130398A1 (en) 2011-06-02
WO2011067185A1 (en) 2011-06-09
IL220010A0 (en) 2012-07-31
CA2781823A1 (en) 2011-06-09
JP5647262B2 (ja) 2014-12-24
KR101418191B1 (ko) 2014-07-09
CL2012001405A1 (es) 2012-09-28
CR20120259A (es) 2012-07-12
NZ600024A (en) 2014-08-29
AU2010326855B2 (en) 2015-10-29
SG181465A1 (en) 2012-07-30
US8088815B2 (en) 2012-01-03
BR112012012872A2 (pt) 2017-10-10
AR079226A1 (es) 2012-01-04
ES2543468T3 (es) 2015-08-19
AU2010326855A1 (en) 2012-06-21
RU2012125763A (ru) 2014-01-10

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