CO5700768A2 - Derivados de benzoxazina y sus usos - Google Patents
Derivados de benzoxazina y sus usosInfo
- Publication number
- CO5700768A2 CO5700768A2 CO06056964A CO06056964A CO5700768A2 CO 5700768 A2 CO5700768 A2 CO 5700768A2 CO 06056964 A CO06056964 A CO 06056964A CO 06056964 A CO06056964 A CO 06056964A CO 5700768 A2 CO5700768 A2 CO 5700768A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- halo
- alkoxy
- independently
- nrbrc
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1.- Un compuesto de la fórmula (I): o una sal o solvato farmacéuticamente aceptable del mismo, en la que:m es un número de 0 a 3;X es N o CH;Y es -SO2- o -CH2- ;cada R1 con independencia de su aparición es halo, (C1-C12)alquilo, halo-(C1-C12)-alquilo, (C1-C12)alcoxi, ciano, hidroxi-(C1-C6)alquilo, alcoxi-(C1-C12)alquilo, -SO2Ra, -C(=O)-NRbRc, -SO2-NRbRc,-SRb, -N(Rb)-C(=O)-Rc, -C(=O)-Rb, o -N(Rb)-SO2-Ra, en los que cada Ra con independencia de su aparición es (C1-C12)alquilo o halo-(C1-C12)-alquilo y cada uno de Rb y Rc con independencia entre si es hidrógeno, (C1-C12)alquilo o halo-(C1-C12)-alquilo, R2 es arilo o heteroarilo opcionalmente sustituido por (C1-C12)alquilo, halo, halo-(C1-C12)alquilo, (C1-C12)alcoxi o ciano;cada uno de R3 y R4 con independencia entre si es (C1-C12)alquilo, hidroxi-(C1-C6)-alquilo o (C1-C12)alcoxi-(C1-C12)alquilo, o R3 y R4 junto con el átomo de carbono al que están unidos pueden formar un grupo cíclico de 3 a 6 átomos en el anillo que opcionalmente incluye un heteroátomo elegido entre N, O y S; y cada uno de R5, R6, R7, R8 y R9 con independencia entre sí es hidrógeno o (C1-C12)alquilo, o R9 y uno de R5, R6, R7 y R8 junto con los átomos a los que están unidos forman un anillo heterocicloamino que tiene de 5 a 7 átomos en el anillo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52837803P | 2003-12-09 | 2003-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5700768A2 true CO5700768A2 (es) | 2006-11-30 |
Family
ID=34699863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO06056964A CO5700768A2 (es) | 2003-12-09 | 2006-06-12 | Derivados de benzoxazina y sus usos |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7202241B2 (es) |
| EP (1) | EP1694656B1 (es) |
| JP (1) | JP4527730B2 (es) |
| KR (1) | KR100827915B1 (es) |
| CN (1) | CN100532369C (es) |
| AR (1) | AR046753A1 (es) |
| AT (1) | ATE371653T1 (es) |
| AU (1) | AU2004299201B2 (es) |
| BR (1) | BRPI0416873A (es) |
| CA (1) | CA2547764A1 (es) |
| CO (1) | CO5700768A2 (es) |
| DE (1) | DE602004008668T2 (es) |
| ES (1) | ES2291984T3 (es) |
| IL (1) | IL175817A0 (es) |
| MY (1) | MY145576A (es) |
| NO (1) | NO20062491L (es) |
| NZ (1) | NZ547120A (es) |
| RU (1) | RU2354651C2 (es) |
| TW (1) | TW200522953A (es) |
| WO (1) | WO2005058847A1 (es) |
| ZA (1) | ZA200604725B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5080716B2 (ja) * | 2001-07-20 | 2012-11-21 | サイコジェニックス・インコーポレーテッド | 注意欠陥・多動性障害の治療 |
| US7713954B2 (en) * | 2004-09-30 | 2010-05-11 | Roche Palo Alto Llc | Compositions and methods for treating cognitive disorders |
| MX2007003545A (es) * | 2004-09-30 | 2007-05-18 | Hoffmann La Roche | Composiciones y metodos para tratar trastornos cognitivos. |
| EP1999121A1 (en) * | 2006-03-17 | 2008-12-10 | AstraZeneca AB | Novel tetralins as 5-ht6 modulators |
| CL2007003044A1 (es) * | 2006-10-24 | 2008-07-04 | Wyeth Corp | Compuestos derivados de benzoxazina; composicion farmaceutica que los comprende; y uso para el tratamiento de un trastorno psicotico, bipolar, depresivo y abuso o dependencia de sustancias entre otros. |
| WO2011023753A1 (en) * | 2009-08-27 | 2011-03-03 | Glaxo Group Limited | Benzoxazine derivatives as glycine transport inhibitors |
| CN101836993B (zh) | 2010-05-20 | 2011-06-22 | 山东大学 | 2，3-二氢-3-羟甲基-6-氨基-[1，4]-苯并噁嗪在制备诱导胚胎干细胞向血管内皮细胞分化药物中的应用 |
| CN102060810B (zh) * | 2010-12-20 | 2012-07-04 | 金坛市爱特生物科技有限公司 | 一种n-叔丁氧羰基-哌嗪的提纯方法 |
| US10532088B2 (en) | 2014-02-27 | 2020-01-14 | Lycera Corporation | Adoptive cellular therapy using an agonist of retinoic acid receptor-related orphan receptor gamma and related therapeutic methods |
| WO2015171558A2 (en) | 2014-05-05 | 2015-11-12 | Lycera Corporation | BENZENESULFONAMIDO AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORγ AND THE TREATEMENT OF DISEASE |
| EP3140291A4 (en) | 2014-05-05 | 2018-01-10 | Lycera Corporation | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of rory and the treatment of disease |
| CN105541693B (zh) | 2014-07-08 | 2018-10-16 | 广东东阳光药业有限公司 | 芳杂环类衍生物及其在药物上的应用 |
| EP3292119A4 (en) | 2015-05-05 | 2018-10-03 | Lycera Corporation | DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE |
| CA2987289A1 (en) | 2015-06-11 | 2016-12-15 | Lycera Corporation | Aryl dihydro-2h-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of ror.gamma. and the treatment of disease |
| CN109568321B (zh) * | 2019-01-14 | 2022-02-22 | 山东轩竹医药科技有限公司 | RORγ调节剂 |
| KR20230050369A (ko) * | 2020-08-07 | 2023-04-14 | 카스마 테라퓨틱스, 인코포레이티드 | Trpml 조절제 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8803419D0 (en) * | 1988-02-15 | 1988-03-16 | Erba Carlo Spa | 1 4-benzoxazine & 1 4-benzothiazine derivatives & process for their preparation |
| GB9507203D0 (en) | 1995-04-07 | 1995-05-31 | Smithkline Beecham Plc | Novel compounds |
| BR9809092A (pt) | 1997-04-18 | 2002-01-22 | Smithkline Beecham Plc | Derivados de indol tendo atividade combinada de antagonista de receptor de 5ht1a, 5ht1b e 5ht1d |
| US6380235B1 (en) | 1999-05-04 | 2002-04-30 | American Home Products Corporation | Benzimidazolones and analogues |
| US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| AU2001236606A1 (en) | 2000-02-01 | 2001-08-14 | Cor Therapeutics, Inc. | 3,4-dihydro-2h-benzo(1,4)oxazine inhibitors of factor xa |
| KR100636475B1 (ko) * | 2002-05-13 | 2006-10-18 | 에프. 호프만-라 로슈 아게 | 5-ｈｔ6 조절제로서 벤족사진 유도체 및 이의 용도 |
| TWI285639B (en) * | 2002-11-08 | 2007-08-21 | Roche Palo Alto Llc | Substituted benzoxazinones and uses thereof |
-
2004
- 2004-11-30 RU RU2006124513/04A patent/RU2354651C2/ru not_active IP Right Cessation
- 2004-11-30 ES ES04820410T patent/ES2291984T3/es not_active Expired - Lifetime
- 2004-11-30 DE DE602004008668T patent/DE602004008668T2/de not_active Expired - Lifetime
- 2004-11-30 KR KR1020067011286A patent/KR100827915B1/ko not_active IP Right Cessation
- 2004-11-30 EP EP04820410A patent/EP1694656B1/en not_active Expired - Lifetime
- 2004-11-30 WO PCT/EP2004/013557 patent/WO2005058847A1/en active IP Right Grant
- 2004-11-30 NZ NZ547120A patent/NZ547120A/en unknown
- 2004-11-30 AT AT04820410T patent/ATE371653T1/de active
- 2004-11-30 CN CNB2004800368183A patent/CN100532369C/zh not_active Expired - Fee Related
- 2004-11-30 AU AU2004299201A patent/AU2004299201B2/en not_active Ceased
- 2004-11-30 CA CA002547764A patent/CA2547764A1/en not_active Abandoned
- 2004-11-30 BR BRPI0416873-9A patent/BRPI0416873A/pt not_active Application Discontinuation
- 2004-11-30 JP JP2006543432A patent/JP4527730B2/ja not_active Expired - Fee Related
- 2004-12-07 MY MYPI20045047A patent/MY145576A/en unknown
- 2004-12-07 AR ARP040104555A patent/AR046753A1/es not_active Application Discontinuation
- 2004-12-08 TW TW093137995A patent/TW200522953A/zh unknown
- 2004-12-09 US US11/008,310 patent/US7202241B2/en not_active Expired - Fee Related
-
2006
- 2006-05-22 IL IL175817A patent/IL175817A0/en unknown
- 2006-05-31 NO NO20062491A patent/NO20062491L/no not_active Application Discontinuation
- 2006-06-08 ZA ZA200604725A patent/ZA200604725B/xx unknown
- 2006-06-12 CO CO06056964A patent/CO5700768A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2354651C2 (ru) | 2009-05-10 |
| IL175817A0 (en) | 2006-10-05 |
| ZA200604725B (en) | 2007-12-27 |
| KR20060097758A (ko) | 2006-09-15 |
| JP2007513904A (ja) | 2007-05-31 |
| EP1694656B1 (en) | 2007-08-29 |
| RU2006124513A (ru) | 2008-01-27 |
| AU2004299201B2 (en) | 2009-12-03 |
| CN100532369C (zh) | 2009-08-26 |
| US7202241B2 (en) | 2007-04-10 |
| NZ547120A (en) | 2009-02-28 |
| MY145576A (en) | 2012-02-29 |
| DE602004008668D1 (de) | 2007-10-11 |
| DE602004008668T2 (de) | 2008-06-12 |
| ES2291984T3 (es) | 2008-03-01 |
| KR100827915B1 (ko) | 2008-05-07 |
| NO20062491L (no) | 2006-09-06 |
| CN1890227A (zh) | 2007-01-03 |
| ATE371653T1 (de) | 2007-09-15 |
| JP4527730B2 (ja) | 2010-08-18 |
| EP1694656A1 (en) | 2006-08-30 |
| TW200522953A (en) | 2005-07-16 |
| BRPI0416873A (pt) | 2007-02-27 |
| US20050124613A1 (en) | 2005-06-09 |
| AR046753A1 (es) | 2005-12-21 |
| AU2004299201A1 (en) | 2005-06-30 |
| WO2005058847A1 (en) | 2005-06-30 |
| CA2547764A1 (en) | 2005-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted | ||
| FD | Application lapsed |