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CO5630024A2 - Compuestos inhibidores de la hepatitis c - Google Patents

Compuestos inhibidores de la hepatitis c

Info

Publication number
CO5630024A2
CO5630024A2 CO05117348A CO05117348A CO5630024A2 CO 5630024 A2 CO5630024 A2 CO 5630024A2 CO 05117348 A CO05117348 A CO 05117348A CO 05117348 A CO05117348 A CO 05117348A CO 5630024 A2 CO5630024 A2 CO 5630024A2
Authority
CO
Colombia
Prior art keywords
hepatitis
inhibiting compounds
compounds
hcv
protease
Prior art date
Application number
CO05117348A
Other languages
English (en)
Inventor
Brunet Montse Llinas
Murray D Bailey
Punit Bhardwaj
Josee Bordeleau
Pasquale Forgione
Elise Ghiro
Vida Gorys
Nathalie Goudreau
Sylvie Goulet
Teddy Halmos
Jean Rancourt
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33476973&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5630024(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CO5630024A2 publication Critical patent/CO5630024A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1.- Un racemato, un diasteroisómero o isómero óptico de un compuesto de fórmula (I): donde B es alquilo (C1-10), cicloalquilo (C3-7), o alquil (C1-4)-cicloalquilo (C3-7), a) donde dicho alquilo, cicloalquilo y alquil-cicloalquilo pueden estar mono-, di- o trisustituidos con alquilo (C1-3); y b) donde dicho alquilo, cicloalquilo y alquil-cicloalquilo pueden estar mono-sustituidos o disustituidos con sustituyentes seleccionados de hidroxi y O-alquilo (C1-4); y c) donde cada uno de dichos grupos alquilo puede estar mono-sustituido, disustituido o trisustituido con halógeno; y d) donde cada uno de dichos grupos cicloalquilo que es de 4, 5, 6 o 7 miembros posee opcionalmente uno (para los de 4, 5, 6, o 7 miembros) o dos (para los de 5, 6, o 7 miembros) grupos -CH2- que no se encuentran unidos entre sí directamente se reemplazan por -O- de manera que el átomo de O se encuentra unido al grupo X mediante al menos dos átomos de C;X es O o NH;R3 es alquilo (C2-8), cicloalquilo (C3-7) o alquil (C1-3)-cicloalquilo (C3-7), donde dichos grupos alquilo, cicloalquilo y alquil-cicloalquilo pueden estar mono-, di- o tri-sustituidos con alquilo (C1-4);L0 es H, halógeno, alquilo (C1-4), -OH, O-alquilo (C1-4), -NH2, -NHalquilo (C1-4) o -N(alquil (C1-4))2;L1, L2 son cada uno independientemente halógeno, ciano, alquilo (C1-4), -O-alquilo (C1-4), -S-alquilo (C1-4), -SO-alquilo (C1-4), o -SO2-alquilo (C1-4), donde cada uno de dichos grupos alquilo está sustituido opcionalmente con de uno a tres átomos de halógeno; y cualquiera de L1 o L2 (pero no los dos al mismo tiempo) también puede ser H; o L0 y L1 o L0 y L2 pueden estar unidos covalentemente para formar, junto con los dos átomos de C a los cuales están unidos, un anillo carbocíclico de 5 o 6 miembros donde uno o dos grupos -CH2- que no están unidos entre sí directamente se pueden reemplazar cada uno independientemente por -O- o NRa, donde Ra es H o alquilo (C1-4) y ...
CO05117348A 2003-05-21 2005-11-18 Compuestos inhibidores de la hepatitis c CO5630024A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47270903P 2003-05-21 2003-05-21

Publications (1)

Publication Number Publication Date
CO5630024A2 true CO5630024A2 (es) 2006-04-28

Family

ID=33476973

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05117348A CO5630024A2 (es) 2003-05-21 2005-11-18 Compuestos inhibidores de la hepatitis c

Country Status (33)

Country Link
US (5) US7585845B2 (es)
EP (1) EP1654261B1 (es)
JP (2) JP4447603B2 (es)
KR (1) KR101115294B1 (es)
CN (3) CN1791599A (es)
AT (1) ATE378334T1 (es)
AU (1) AU2004240704B9 (es)
BR (1) BRPI0410456B8 (es)
CA (1) CA2522577C (es)
CL (1) CL2004001161A1 (es)
CO (1) CO5630024A2 (es)
CY (1) CY1107200T1 (es)
DE (1) DE602004010137T2 (es)
DK (1) DK1654261T3 (es)
EA (1) EA009295B1 (es)
EC (1) ECSP056181A (es)
ES (1) ES2297424T3 (es)
HR (1) HRP20080014T3 (es)
IL (1) IL172013A (es)
ME (1) MEP58308A (es)
MX (1) MXPA05012545A (es)
MY (1) MY143076A (es)
NO (1) NO332056B1 (es)
NZ (1) NZ544076A (es)
PE (1) PE20050204A1 (es)
PL (1) PL1654261T3 (es)
PT (1) PT1654261E (es)
RS (1) RS51294B (es)
TW (1) TWI327145B (es)
UA (1) UA83046C2 (es)
UY (1) UY28323A1 (es)
WO (1) WO2004103996A1 (es)
ZA (1) ZA200508201B (es)

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