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CO5280081A1 - Antibacterianos de piperidiniloxi oxazolidinona, composicion farmaceutica que los comprende y proceso para su preparacion - Google Patents

Antibacterianos de piperidiniloxi oxazolidinona, composicion farmaceutica que los comprende y proceso para su preparacion

Info

Publication number
CO5280081A1
CO5280081A1 CO00097143A CO00097143A CO5280081A1 CO 5280081 A1 CO5280081 A1 CO 5280081A1 CO 00097143 A CO00097143 A CO 00097143A CO 00097143 A CO00097143 A CO 00097143A CO 5280081 A1 CO5280081 A1 CO 5280081A1
Authority
CO
Colombia
Prior art keywords
alkyl
theteroaryl
taryl
chr5r6
jpeg
Prior art date
Application number
CO00097143A
Other languages
English (en)
Inventor
Michele Well-Weidner
Christine Boggs
Dennis Hlasta
Eric Nelson
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of CO5280081A1 publication Critical patent/CO5280081A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Proveer un compuesto de la fórmula (I)<EMI FILE="00097143_1" ID="1" IMF=JPEG >en dondeR1 se selecciona entre<EMI FILE="00097143_2" ID="2" IMF=JPEG >En dondeR3 se selecciona entre H, alquilo, -COR4, -(CH2)theteroarilo, -CHR5R6, -(CH2)tarilo, -SO2NR5R6 y -SO2R9;R4 se selecciona entre H, -OR5, alquilo, alquilarilo, -(CH2)tarilo, -(CH2)theteroarilo, -(CH2)tOR5, -(CH2)tNR7R8, -CHR5R6 y -NR5R6 opcionalmente formando un derivado amino cíclico;R5 y R6 se seleccionan independientemente entre H, alquilo, alquilarilo, haloarilo, -(CH2)tarilo, (CH2)theteroarilo y acilo;R7 y R8 se seleccionan independientemente entre H, alquilo, -COR9, SO2R9 y -CO2R9; yR9 se selecciona entre H, alquilo, arilo y alquilarilo; R2 se selecciona entre C(O)R9, C(O)R9,<EMI FILE="00097143_3" ID="3" IMF=JPEG >R2a es H o acilo, con la condición que cuando R3 se selecciona entre alquilo, (CH2)tarilo, -(CH2)theteroarilo y -CHR5R6, R2a es H;X es N o CH;Y se selecciona entre H, halógeno, alcoxi y alquilo; y t es un entero de 0 a 4;O un isómero óptico, enantiómero, diastereómero, racemato o mezcla racémica de los mismos, o una sal farmacéuticamente aceptable de los mismos.
CO00097143A 1999-12-21 2000-12-21 Antibacterianos de piperidiniloxi oxazolidinona, composicion farmaceutica que los comprende y proceso para su preparacion CO5280081A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17292399P 1999-12-21 1999-12-21
US09/729,342 US6518285B2 (en) 1999-12-21 2000-12-05 Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials

Publications (1)

Publication Number Publication Date
CO5280081A1 true CO5280081A1 (es) 2003-05-30

Family

ID=22629768

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00097143A CO5280081A1 (es) 1999-12-21 2000-12-21 Antibacterianos de piperidiniloxi oxazolidinona, composicion farmaceutica que los comprende y proceso para su preparacion

Country Status (17)

Country Link
US (1) US6518285B2 (es)
EP (1) EP1246810B1 (es)
JP (1) JP2003518106A (es)
CN (1) CN1227238C (es)
AR (1) AR029420A1 (es)
AT (1) ATE326452T1 (es)
AU (1) AU784314B2 (es)
CA (1) CA2395204C (es)
CO (1) CO5280081A1 (es)
CY (1) CY1106124T1 (es)
DE (1) DE60028085T2 (es)
DK (1) DK1246810T3 (es)
ES (1) ES2265365T3 (es)
MX (1) MXPA02006323A (es)
MY (1) MY127677A (es)
PT (1) PT1246810E (es)
WO (1) WO2001046164A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
US6940748B2 (en) 2002-05-16 2005-09-06 Micron Technology, Inc. Stacked 1T-nMTJ MRAM structure
WO2004069816A1 (en) * 2003-02-07 2004-08-19 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
DE602004014361D1 (de) 2003-04-30 2008-07-24 Morphochem Ag Komb Chemie Verwendung von oxazolidinon-chinolin-hybrid-antibiotika zur behandlung von anthrax und anderen infektionen
DE10340485B4 (de) * 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
DK1709044T4 (da) 2003-12-18 2014-01-20 Morphochem Ag Komb Chemie Oxazolidinon-quinolon-hybridantibiotika
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US7829712B2 (en) * 2004-09-20 2010-11-09 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
AR051093A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de estearoil-coa desaturasa
TW200624427A (en) 2004-09-20 2006-07-16 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
CA2580787A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
BRPI0515478A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos e seu uso como mediadores de estearoil-coa-desaturase
JP2009513563A (ja) 2005-06-03 2009-04-02 ゼノン・ファーマシューティカルズ・インコーポレイテッド ヒトのステアロイル−ＣｏＡデサチュラーゼ阻害剤としてのアミノチアゾール誘導体
EP1939175B1 (en) 2005-09-27 2017-03-01 Shionogi&Co., Ltd. Sulfonamide derivative having pgd2 receptor antagonistic activity
JP5209254B2 (ja) * 2007-08-30 2013-06-12 日本曹達株式会社 置換フェノキシアザビシクロオクタン誘導体の製造方法
CN108785728A (zh) * 2017-05-05 2018-11-13 国家纳米科学中心 含药物中间体修饰的纳米金的抗菌敷料、其制备方法及应用
CN109503569B (zh) * 2019-01-03 2021-01-15 山东大学 噻唑类衍生物及其制备方法和应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA844265B (en) * 1983-06-07 1986-01-29 Du Pont Aminomethyl oxooxazolidinyl benzene derivatives useful as antinbacterial agents
US4705799A (en) 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
ES8506659A1 (es) 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
AU667198B2 (en) 1991-11-01 1996-03-14 Pharmacia & Upjohn Company Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
DK0792273T3 (da) 1994-11-15 2003-06-16 Upjohn Co Bicycliske oxazin- og thiazin-oxazolidinon-antibakterielle midler
US6124334A (en) 1995-02-03 2000-09-26 Pharmacia & Upjohn Company Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials
KR100441334B1 (ko) 1995-02-03 2004-10-20 파마시아 앤드 업존 캄파니 헤테로-방향족고리치환된페닐옥사졸리딘온항균제
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
CN1068328C (zh) 1995-05-11 2001-07-11 法玛西雅厄普约翰美国公司 螺环和双环二嗪基和咔嗪基噁唑烷酮类
MX9703040A (es) 1995-09-12 1997-07-31 Upjohn Co Antimicrobianos de feniloxazolidinona.
DE19601264A1 (de) 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
ES2298198T3 (es) 1996-04-11 2008-05-16 PHARMACIA &amp; UPJOHN COMPANY LLC Procedimiento para preparar oxazolidinonas.
CN1138765C (zh) 1997-05-30 2004-02-18 法玛西雅厄普约翰美国公司 带有硫代羰基功能基的噁唑烷酮抗菌剂
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JPH11322729A (ja) 1998-03-09 1999-11-24 Hokuriku Seiyaku Co Ltd ジチオカルバミド酸誘導体
JP2000204084A (ja) * 1998-11-11 2000-07-25 Hokuriku Seiyaku Co Ltd チオカルバミド酸誘導体

Also Published As

Publication number Publication date
WO2001046164A1 (en) 2001-06-28
JP2003518106A (ja) 2003-06-03
CN1434810A (zh) 2003-08-06
ES2265365T3 (es) 2007-02-16
CA2395204A1 (en) 2001-06-28
PT1246810E (pt) 2006-08-31
EP1246810B1 (en) 2006-05-17
MY127677A (en) 2006-12-29
CA2395204C (en) 2008-02-05
AU2261701A (en) 2001-07-03
CY1106124T1 (el) 2011-06-08
MXPA02006323A (es) 2003-09-22
DE60028085T2 (de) 2006-12-07
CN1227238C (zh) 2005-11-16
US20020103377A1 (en) 2002-08-01
EP1246810A1 (en) 2002-10-09
ATE326452T1 (de) 2006-06-15
AU784314B2 (en) 2006-03-09
AR029420A1 (es) 2003-06-25
DK1246810T3 (da) 2006-09-18
DE60028085D1 (de) 2006-06-22
US6518285B2 (en) 2003-02-11

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