CO2018007535A2 - Análogos de cortistatina y usos de los mismos - Google Patents
Análogos de cortistatina y usos de los mismosInfo
- Publication number
- CO2018007535A2 CO2018007535A2 CONC2018/0007535A CO2018007535A CO2018007535A2 CO 2018007535 A2 CO2018007535 A2 CO 2018007535A2 CO 2018007535 A CO2018007535 A CO 2018007535A CO 2018007535 A2 CO2018007535 A2 CO 2018007535A2
- Authority
- CO
- Colombia
- Prior art keywords
- human
- advantageous
- low
- administration
- cortistatin analogues
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Se proporcionan derivados de cortistatina específicos con propiedades ventajosas para la administración in vivo a un huésped, que incluye un ser humano, que lo necesita. Estas nuevas especies tienen una farmacocinética ventajosa, baja toxicidad, actividad hERG de baja a moderada y/o otras propiedades farmacológicas que los hacen destacar entre la clase de cortistatinas como candidatos superiores para la administración humana.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562387246P | 2015-12-23 | 2015-12-23 | |
| US201662297494P | 2016-02-19 | 2016-02-19 | |
| PCT/US2016/068125 WO2017112815A1 (en) | 2015-12-23 | 2016-12-21 | Cortistatin analogs and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2018007535A2 true CO2018007535A2 (es) | 2018-07-31 |
Family
ID=59091204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2018/0007535A CO2018007535A2 (es) | 2015-12-23 | 2018-07-18 | Análogos de cortistatina y usos de los mismos |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20180298024A1 (es) |
| EP (1) | EP3394072A4 (es) |
| JP (1) | JP2019508368A (es) |
| KR (1) | KR20180095051A (es) |
| CN (1) | CN108699085A (es) |
| AU (1) | AU2016377678A1 (es) |
| BR (1) | BR112018012647A2 (es) |
| CA (1) | CA3009324A1 (es) |
| CL (1) | CL2018001733A1 (es) |
| CO (1) | CO2018007535A2 (es) |
| EA (1) | EA201891511A1 (es) |
| IL (1) | IL260123A (es) |
| MX (1) | MX2018007804A (es) |
| PH (1) | PH12018501351A1 (es) |
| RU (1) | RU2018126984A (es) |
| SG (1) | SG11201805092WA (es) |
| WO (1) | WO2017112815A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3317269T3 (pl) | 2015-07-02 | 2023-01-02 | F. Hoffmann-La Roche Ag | Laktamy bicykliczne jako inhibitory kinazy białka oddziałującego z receptorem-1 (rip1) do leczenia np. chorób zapalnych |
| JP7349359B2 (ja) | 2016-10-17 | 2023-09-22 | エフ． ホフマン－ラ ロシュ アーゲー | 二環式ピリドンラクタム及びその使用方法。 |
| US11072607B2 (en) | 2016-12-16 | 2021-07-27 | Genentech, Inc. | Inhibitors of RIP1 kinase and methods of use thereof |
| JP7398391B2 (ja) | 2018-04-20 | 2023-12-14 | エフ． ホフマン－ラ ロシュ アーゲー | Ｎ－［４－オキソ－２，３－ジヒドロ－１，５－ベンズオキサゼピン－３－イル］－５，６－ジヒドロ－４Ｈ－ピロロ［１，２－ｂ］ピラゾール－２－カルボキサミド誘導体及び例えば過敏性腸症候群（ＩＢＳ）を処置するためのＲＩＰ１キナーゼ阻害剤としての関連化合物 |
| WO2020093011A1 (en) * | 2018-11-01 | 2020-05-07 | Syros Pharmaceuticals, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| CA3214794A1 (en) * | 2021-03-25 | 2022-09-29 | University Of South Carolina | Cdk8/19 inhibitors for the treatment of cytokine storm |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009137337A1 (en) * | 2008-05-05 | 2009-11-12 | The Scripps Research Institute | STEREOSELECTIVE SYNTHESIS OF 17-α -AND 17-β -ARYL STEROIDAL COMPOUNDS |
| EP2334686B1 (en) * | 2008-08-28 | 2019-02-27 | President and Fellows of Harvard College | Cortistatin analogues and syntheses therof |
| US20130217014A1 (en) * | 2012-02-17 | 2013-08-22 | Genentech, Inc. | Methods of using cdk8 antagonists |
| WO2014123900A1 (en) * | 2013-02-05 | 2014-08-14 | Sirenas Marine Discovery | Anti-cancer and anti-hiv compounds |
| SG10201808151RA (en) * | 2013-12-24 | 2018-10-30 | Harvard College | Cortistatin analogues and syntheses and uses thereof |
-
2016
- 2016-12-21 EP EP16880055.5A patent/EP3394072A4/en not_active Withdrawn
- 2016-12-21 EA EA201891511A patent/EA201891511A1/ru unknown
- 2016-12-21 CN CN201680082319.0A patent/CN108699085A/zh active Pending
- 2016-12-21 CA CA3009324A patent/CA3009324A1/en not_active Abandoned
- 2016-12-21 AU AU2016377678A patent/AU2016377678A1/en not_active Abandoned
- 2016-12-21 SG SG11201805092WA patent/SG11201805092WA/en unknown
- 2016-12-21 KR KR1020187020634A patent/KR20180095051A/ko unknown
- 2016-12-21 BR BR112018012647A patent/BR112018012647A2/pt not_active Application Discontinuation
- 2016-12-21 JP JP2018532374A patent/JP2019508368A/ja active Pending
- 2016-12-21 MX MX2018007804A patent/MX2018007804A/es unknown
- 2016-12-21 WO PCT/US2016/068125 patent/WO2017112815A1/en active Application Filing
- 2016-12-21 RU RU2018126984A patent/RU2018126984A/ru not_active Application Discontinuation
-
2018
- 2018-06-18 IL IL260123A patent/IL260123A/en unknown
- 2018-06-22 CL CL2018001733A patent/CL2018001733A1/es unknown
- 2018-06-22 US US16/016,199 patent/US20180298024A1/en not_active Abandoned
- 2018-06-22 PH PH12018501351A patent/PH12018501351A1/en unknown
- 2018-07-18 CO CONC2018/0007535A patent/CO2018007535A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112018012647A2 (pt) | 2018-12-04 |
| AU2016377678A1 (en) | 2018-07-12 |
| IL260123A (en) | 2018-07-31 |
| EP3394072A1 (en) | 2018-10-31 |
| EA201891511A1 (ru) | 2018-12-28 |
| WO2017112815A1 (en) | 2017-06-29 |
| CN108699085A (zh) | 2018-10-23 |
| EP3394072A4 (en) | 2019-05-29 |
| MX2018007804A (es) | 2019-07-04 |
| US20180298024A1 (en) | 2018-10-18 |
| RU2018126984A (ru) | 2020-01-23 |
| CA3009324A1 (en) | 2017-06-29 |
| JP2019508368A (ja) | 2019-03-28 |
| CL2018001733A1 (es) | 2018-11-09 |
| KR20180095051A (ko) | 2018-08-24 |
| PH12018501351A1 (en) | 2019-02-27 |
| SG11201805092WA (en) | 2018-07-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO2018007535A2 (es) | Análogos de cortistatina y usos de los mismos | |
| ECSP17078433A (es) | Composiciones de ácido obeticólico y métodos de uso | |
| CL2023001911A1 (es) | Derivado de glucagón y una composición que comprende un conjugado de acción prolongada del mismo | |
| ECSP18053055A (es) | Agonista triple de receptores de glucagón/glp-1/gip | |
| DOP2017000298A (es) | Reguladores de nrf2 | |
| CL2017001736A1 (es) | Anticuerpos anti-cd47 y uso de los mismos. | |
| CO2017001994A2 (es) | Compuestos activos hacia bromodominios | |
| UY35351A (es) | Formulaciones acuosas estables de adalimumab | |
| DOP2015000241A (es) | Compuestos de biaril-amida como inhibidores de cinasa | |
| UY36143A (es) | Derivados de pirazolo-pirimidina novedosos | |
| CL2014003136A1 (es) | Nuevos diazaespirocicloalcanos y azaespirocicloalcanos; composicion farmaceutica que los contiene y usos. | |
| CL2017001923A1 (es) | Derivados de 9h-pirrolo-dipiridina | |
| CR20150549A (es) | Compuestos heterocíclicos y sus usos | |
| SV2017005412A (es) | Compuestos de 1-alquil-6-oxo-1,6-dihidropiridin-3-ilo y usos de los mismos | |
| ECSP17074645A (es) | Azabenzimidazoles y su uso como moduladores del receptor ampa | |
| UY37193A (es) | Nuevos compuestos antivíricos | |
| CL2015001446A1 (es) | Procedimiento de preparación de albumina humana con nivel de oxigeno disuelto reducido. | |
| CR20160448A (es) | Nuevos derivados de piridina | |
| UY35997A (es) | Derivados de isoquinoleína, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| UY36117A (es) | Composiciones farmacéuticas para el tratamiento de enfermedades infecciosas. | |
| AR093939A1 (es) | Composiciones que comprenden vortioxetina y donepezil | |
| CR20150653A (es) | Compuestos nuevos para el tratamiento del cáncer | |
| DOP2017000058A (es) | Derivados de tetrahidroquinolina como inhibidores del bromodominio | |
| GT201600252A (es) | Derivados de naftiridinadiona | |
| UY34761A (es) | Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos. |