Starting electrode and biosensor
Technical Field
The utility model belongs to the biosensor field especially relates to a start electrode and biosensor.
Background
At present, disposable biosensors used as point-of-care testing (POCT) products are receiving more and more attention due to their characteristics of portability, rapidness, simple operation, low price, etc., wherein blood glucose test strips (i.e., sensors) of electrochemical methods are widely used in hospitals and families. With the improvement of living standard and the attention on self health management, the detection of indexes such as uric acid, blood ketone, cholesterol, lactic acid and the like in blood samples is increasingly required, and the detection of multiple indexes in the same biosensor and the same detection instrument is increasingly required. At present, a product which can simultaneously detect two indexes by one biosensor can be found in the market, and if the indexes are combined in pairs, an instrument is required to identify the biosensors with different combinations, so that corresponding test and operation are carried out.
Chinese patent publication CN108872322A provides a test paper with automatic identification and differentiation information, which includes a test paper type identification module and a measurement module, where the test paper type identification module is composed of a loop formed by a working electrode and a starting electrode. The loop of the test paper type identification module is formed by forming carbon resistors with different resistance values between the working electrode and the starting electrode in a screen printing mode, the carbon resistors with different resistance values correspond to test paper with different detection indexes, and a test instrument identifies the corresponding test paper types according to the different resistance values by detecting the resistance values in the loop. This method requires different screen printing plates to be manufactured, the required resistance is different, and the printing plates are different, which increases the manufacturing cost and causes waste to a certain extent.
SUMMERY OF THE UTILITY MODEL
In order to overcome the deficiency of the prior art, the utility model provides a when the biosensor of different indexs of discernment detection, need not to customize printing half tone again and just can obtain multiple identification mode, low in manufacturing cost can also increase the start electrode structure of biosensor code quantity and have this start electrode structure's biosensor.
The utility model provides a technical scheme that its technical problem adopted is: a starting electrode structure comprises a starting electrode, a contact and a connecting electrode, wherein the connecting electrode can be respectively connected with electrodes of a biosensor.
The starting electrode is provided with at least two fractures, a plurality of sections of electrodes formed by the fractures are mutually parallel, two adjacent sections of electrodes are connected through the starting resistor, and the resistance value of the starting resistor can be changed through laser cutting or burning.
Further, the on-resistance has a trace cut or burned by a laser.
Furthermore, the starting resistor can obtain a resistance values through a laser cutting or burning modes, wherein the a laser cutting or burning modes comprise cutting or burning to form tracks with different lengths, or cutting or burning to form tracks with different shapes, or cutting or burning to form tracks with different numbers.
The utility model also discloses a biosensor, which comprises a substrate layer and an electrode layer, wherein the electrode layer comprises a starting electrode structure and X electrodes, and the starting electrode structure comprises a starting electrode, contacts and Y connecting electrodes; the biosensor has a first state and a second state; in the first state, the Y connecting electrodes are respectively connected with Y electrodes in the X working electrodes, in the second state, only one connecting electrode is connected with one working electrode, and the rest connecting electrodes are in a disconnected state, wherein X is more than or equal to Y + 1.
Preferably, the biosensor has Y types of power-on modes, and the Y types of power-on modes correspond to Y identifiable biosensor combinations.
Preferably, the starting electrode structure further comprises a starting resistor connected between the starting electrode and the contact, the starting electrode structure is provided with at least two fractures, the multiple sections of electrodes formed by the fractures are parallel to each other, the two adjacent sections of electrodes are connected through the starting resistor, and the resistance value of the starting resistor can be changed through laser cutting or burning.
Preferably, the starting-up resistor can obtain a resistance values through a laser cutting or burning modes, and the biosensor has a starting-up modes a x Y corresponding to a identifiable biosensor combinations.
Preferably, the a laser cutting or burning modes include cutting or burning to form traces with different lengths, or cutting or burning to form traces with different shapes, or cutting or burning to form traces with different numbers.
Preferably, the on-resistance has a trace that is cut or fired by a laser.
The utility model has the advantages that: presetting a startup electrode to be connected with Y electrodes of the biosensor, and then disconnecting the Y electrodes to form Y detectable connection modes, namely forming Y startup electrode types, wherein multiple identifiable combinations can be obtained corresponding to Y different identifiable biosensors without customizing a printing screen again; the biosensor can also be used for realizing the amplification of the coding region by matching with the resistance selection of the coding region, and the number of codes of the biosensor is increased, so that the manufacturing cost is reduced.
Drawings
Fig. 1 is a schematic structural diagram of a biosensor according to an embodiment of the present invention.
Fig. 2 is a schematic structural diagram of a second biosensor according to an embodiment of the present invention.
Fig. 3 is a schematic structural diagram of three biosensors according to an embodiment of the present invention.
Fig. 4 is a schematic structural diagram of four biosensors according to an embodiment of the present invention.
Detailed Description
In order to make the technical solution of the present invention better understood, the following figures in the embodiments of the present invention are combined to clearly and completely describe the technical solution in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts shall belong to the protection scope of the present invention.
Example one
As shown in fig. 1, a biosensor 700 includes a first electrode 701, a first contact 1, a third electrode 703, a third contact 3, a fourth electrode 704, a fourth contact 4, a fifth electrode 705, a fifth contact 5, a first resistor 706, a second resistor 707, a third resistor 708, and a fourth resistor 709; i.e. X ═ 4; the first electrode 701 is provided with a first fracture 7011 and a second fracture 7012, the part above the first fracture 7011 and the part below the second fracture 7012 are arranged in parallel relatively and are connected through a second resistor 707; the fifth electrode 705 has a third fracture 7051 and a fourth fracture 7052, wherein the parts above the third fracture 7051 and the parts below the fourth fracture 7052 are arranged in parallel relatively and are connected through a fourth resistor 709.
The biosensor 700 further comprises a start-up electrode structure 702, the start-up electrode structure 702 comprises a contact 2, a start-up resistor 7021 and three connecting electrodes, i.e. Y3 and X Y +1, the start-up resistor 7021 can change a resistance value by laser cutting or burning, and the three connecting electrodes can be respectively connected with the first electrode 701 (including the first contact 1), the fifth electrode 705 (including the fifth contact 5) or the third electrode 703 (including the third contact 3).
The biosensor 700 has a first state in which the start-up electrode structure 702 is connected to the first electrode 701, the third electrode 703, and the fifth electrode 705, respectively, and a second state in which any two of the three connections have been cut off, and the start-up electrode structure 702 is uniquely connected to one of the electrodes, and there are three types of biosensor identification modes in total, that is, the biosensor 700 has 3 start-up modes corresponding to 3 identifiable biosensor combinations, in which the start-up electrode structure 702 is connected to the first electrode 701 (the other two connections are disconnected), the start-up electrode structure 702 is connected to the third electrode 703 (the other two connections are disconnected), and the start-up electrode structure 702 is connected to the fifth electrode 705 (the other two connections are disconnected). If the on-resistor 7021 obtains a resistance values by a laser cutting or burning methods, the biosensor 700 has a × Y — 3a on-modes, which can correspond to a × Y — 3a biosensor types.
Example two
As shown in fig. 2, a biosensor 800 includes a first electrode 801, a first contact 1, a third electrode 803, a third contact 3, a fourth electrode 804, a fourth contact 4, a fifth electrode 805, a fifth contact 5, a sixth electrode 806, a sixth contact 6, a first resistor 807, a second resistor 808, a third resistor 809, and a fourth resistor 810; i.e., X ═ 5; the first electrode 801 has a first fracture 8011 and a second fracture 8012, and a portion above the first fracture 8011 and a portion below the second fracture 8012 are arranged in parallel and connected through a first resistor 807.
The biosensor 800 further comprises a switch-on electrode structure 802, the switch-on electrode structure 802 comprising a contact 2, a switch-on resistor 8021 and four connection electrodes, i.e. Y-4 and X-Y +1, which may be connected to the first electrode 801 (comprising the first contact 1) or the fourth electrode 804 (comprising the fourth contact 4) or the sixth electrode 806 (comprising the sixth contact 6) or the third electrode 803 (comprising the third contact 3), respectively.
The biosensor 800 has a first state, in which the on electrode structure 802 is connected to the first 801, third 803, fourth 804 and sixth 806 electrodes respectively, in the second state, any three of the four connections have been severed, and the start-up electrode structure 802 is uniquely connected to one of the electrodes, in four ways, namely four biosensor identification modes of connecting the starting electrode structure 802 with the first electrode 801 (other three disconnected), connecting the starting electrode structure 802 with the third electrode 803 (other three disconnected), connecting the starting electrode structure 802 with the fourth electrode 804 (other three disconnected), and connecting the starting electrode structure 802 with the sixth electrode 806 (other three disconnected), that is, the biosensor has 4 startup modes, corresponding to 4 identifiable biosensor combinations.
EXAMPLE III
As shown in fig. 3, a biosensor 900 includes a first electrode 901, a first contact 1, a third electrode 903, a third contact 3, a fourth electrode 904, a fourth contact 4, a fifth electrode 905, a fifth contact 5, a sixth electrode 906, a sixth contact 6, a seventh electrode 907, a seventh contact 7, a first resistor 908, a second resistor 909, a third resistor 910, and a fourth resistor 911; i.e., X ═ 6; the first electrode 901 has a first fracture 9011 and a second fracture 9012, and a part above the first fracture 9011 and a part below the second fracture 9012 are arranged in parallel relatively and connected through a first resistor 908.
Biosensor 900 further comprises a start-up electrode structure 902, where start-up electrode structure 902 comprises a contact 2, a start-up resistor 9021, and five connection electrodes, i.e., Y-5 and X-Y +1, which may be connected to first electrode 901, fifth electrode 905, seventh electrode 907, third electrode 903, or fourth electrode 904, respectively.
The biosensor 900 has a first state and a second state, in the first state, the start-up electrode structure 902 is respectively connected with the first electrode 901 (including the first contact 1), the third electrode 903 (including the third contact 3), the fourth electrode 904 (including the fourth contact 4), the fifth electrode 905 (including the fifth contact 5) and the seventh electrode 907 (including the seventh contact 7), in the second state, any four of the five connections have been cut off, the start-up electrode structure 902 is uniquely connected with one of the electrodes, and there are five ways, that is, the start-up electrode structure 902 is connected with the first electrode 901 (the other four connections are broken), the start-up electrode structure 902 is connected with the third electrode 903 (the other four connections are broken), the start-up electrode structure 902 is connected with the fourth electrode 904 (the other four connections are broken), and the start-up electrode structure is connected with the fifth electrode 902 (the other four connections are broken), The turn-on electrode structure 902 is connected to the seventh electrode 907 (the other four connections are disconnected), and five biosensor identification modes are provided, that is, the biosensor has 5 turn-on modes, which correspond to 5 identifiable biosensor combinations.
The connection option of the start electrode can also be used for amplification of the coding region, as shown in fig. 4, the loop formed by the fifth electrode 5 and the sixth electrode 6 comprises a variable resistor R1, the loop formed by the sixth contact 6, the sixth electrode 606, the seventh contact 7 and the seventh electrode 607 comprises a variable resistor R2, the loop formed by the seventh contact 7, the seventh electrode 607, the eighth contact 8 and the eighth electrode 8 comprises a variable resistor R3, and the loop formed by the third contact 3, the third electrode 603, the seventh contact 7 and the seventh electrode 607 comprises a variable resistor R4.
The resistor R1, the resistor R2, the resistor R3 and the resistor R4 respectively form three independent parallel circuits, if the resistor R1 has a laser cutting or burning modes, the resistor R2 has b laser cutting or burning modes, the resistor R3 has c laser cutting or burning modes, the resistor R4 has d laser cutting or burning modes, the resistance range of the coding region is at most a, b, c and d, and at least (a-1), b-1, c-1, d-1, when the resistors are combined in pairs to form the channel, the laser cutting or burning modes of the two resistors in the same channel are different in number, and one of the laser cutting or burning modes is a prime number. If the starting selection function is simultaneously considered for the amplification of the coding region, the cutting can be completed simultaneously with the cutting of the coding region resistance, 6 cutting in 6 connections can be realized, the total coding region range can be expanded to be at most 6 a b c d, at least 6 a (a-1) b (b-1) c (c-1) d-1, when the resistances are combined in pairs to form a channel, the laser cutting or burning modes of the two resistances in the same channel are different in number, and one of the two resistances is a prime number.
The process of determining the code by the instrument can be exemplified by:
1. the sensor, for which the first state has been determined, is inserted into the test instrument, the pins of the connector inside the test instrument are connected to the electrode terminals of the biosensor, the test instrument provides an induced voltage to be applied to the contact 2 and the first contact 1, the third contact 3, the fourth contact 4, the fifth contact 5, the sixth contact 6 and the eighth contact 8 (corresponding to the code sections A, B, C, D, E and F), and at this time, only one circuit is connected and detected, for example, only the contact 2 is connected to the first contact 1, and the biosensor enters the start position;
2. the detecting instrument provides a fixed voltage to be applied to the detected contact 2 and the first contact 1, and the resistance value of the starting resistor 6021 is measured to be RfIdentifying a corresponding coding interval, and marking as a coding interval A;
3. the detecting instrument provides fixed voltage to be applied to the fifth contact 5 and the sixth contact 6, the seventh electrode 7 and the sixth contact 6, the eighth contact 8 and the seventh contact 7, and the seventh contact 7 and the third contact 3 respectively, so as to measure four groups of resistancesValue, the resistance values and R of the four groups of resistorsfThe ratios of (A) to (B) are recorded as F1, F2, F3 and F4;
4. the code values corresponding to the code combination formed by A, F1, F2, F3 and F4 are determined by embedding a preset code set, and the code values of the code sections B, C, D, E, F respectively combined with F1, F2, F3 and F4 can be determined in the same way.
Example four
As shown in fig. 4, a biosensor 600 includes a first electrode 601, a first contact 1, a third electrode 603, a third contact 3, a fourth electrode 604, a fourth contact 4, a fifth electrode 605, a fifth contact 5, a sixth electrode 606, a sixth contact 6, a seventh electrode 607, a seventh contact 7, an eighth electrode 608, an eighth contact 8, a first resistor 609, a second resistor 610, a third resistor 611, and a fourth resistor 612.
Biosensor 600 further comprises a turn-on electrode structure 602, the turn-on electrode structure 602 comprising contact 2, a turn-on resistor 6021 and six connecting electrodes that can be connected to a first electrode 601 (comprising first contact 1) or a fifth electrode 605 (comprising fifth contact 5) or a sixth electrode 606 (comprising sixth contact 6) or an eighth electrode 608 (comprising eighth contact 8) or a third electrode 603 (comprising third contact 3) or a fourth electrode 604 (comprising fourth contact 4), respectively.
Biosensor 600 has a first state in which start-up electrode structure 602 is connected to first electrode 601, third electrode 603, fourth electrode 604, fifth electrode 605, sixth electrode 606, and eighth electrode 608, respectively, and a second state in which any five of the six connections have been cut off, and at this time, start-up electrode structure 602 is uniquely connected to one of the electrodes, for a total of six modes, namely, six biosensor types in which start-up electrode structure 602 is connected to first electrode 601 (the other five connections are disconnected), start-up electrode structure 602 is connected to third electrode 603 (the other five connections are disconnected), start-up electrode structure 602 is connected to fourth electrode 604 (the other five connections are disconnected), start-up electrode structure 602 is connected to fifth electrode 605 (the other five connections are disconnected), start-up electrode structure 602 is connected to sixth electrode 606 (the other five connections are disconnected), and start-up electrode structure 602 is connected to eighth electrode 608 (the other five connections are disconnected) In other ways, there are 6 startup modes for the biosensors, corresponding to 6 identifiable biosensor combinations.
The above detailed description is provided for illustrative purposes, and is not intended to limit the present invention, and any modifications and variations of the present invention are within the spirit and scope of the following claims.