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CN109142484A - A kind of parameter recognition component and exempt from bar code bio-sensing test paper - Google Patents

A kind of parameter recognition component and exempt from bar code bio-sensing test paper Download PDF

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Publication number
CN109142484A
CN109142484A CN201810813989.6A CN201810813989A CN109142484A CN 109142484 A CN109142484 A CN 109142484A CN 201810813989 A CN201810813989 A CN 201810813989A CN 109142484 A CN109142484 A CN 109142484A
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China
Prior art keywords
recognition component
parameter
detecting instrument
parameter recognition
test paper
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庄朋强
夏晓风
刘虎
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Qingdao Grace Biotechnology Co Ltd
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Qingdao Grace Biotechnology Co Ltd
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Priority to CN201810813989.6A priority Critical patent/CN109142484A/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/4163Systems checking the operation of, or calibrating, the measuring apparatus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/48Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

The invention discloses a kind of parameter recognition component and exempt from bar code bio-sensing test paper, the invention discloses a kind of special parameter recognition components, it includes a substrate, a conductive layer with special construction on substrate, the conductive layer can change the connection type between conductive layer top electrode by way of punching or laser cutting, constitute different turn-on logics.Special parameter recognition component provided by the present invention can be applied to field of biosensors, when sensor is connect with detecting instrument, matched detection device can be identified by turn-on logic different on parameter recognition component, and automatically select one group of correction parameter values corresponding to this batch of bio-sensing test paper.

Description

A kind of parameter recognition component and exempt from bar code bio-sensing test paper
Technical field
The present invention relates to a kind of biosensor identification field more particularly to parameter recognition component and exempt from bar code biology Sensing test-paper.
Background technique
It is clinically Biochemical Analyzer to the detection master equipment to be used of biochemical indicator, but the Biochemical Analyzer testing time It is long, complicated for operation it is cumbersome, cannot achieve and quickly and easily detect.In recent years, inexpensive, easy due to enzyme electrode biosensor The features such as manufacture, portable, are more and more widely used in the detection of various biochemical indicators, are passed by portable biology Sensor detects biochemical indicator, and not only sample dosage is few, easy to be quick, and is suitable for detecting immediately, is not limited by time, place, Comprehensive for 24 hours is patient service.
By taking blood sugar test paper as an example, blood glucose is most frequent one of the test index of biochemistry detection.Electrochemical blood glucose detection system Successfully developed for more than 30 years, the annual whole world about consumes 6,000,000,000 Electrochemical blood glucose test papers, and blood sugar test paper can be by Professional carries out blood sugar monitoring at home or in medical institutions with the layman of diabetes or its family members, is glycosuria Patient implements the important means that blood glucose self detects, effectively controls the state of an illness.
Well known blood sugar test paper is with cap rock on interlayer and one in a substrate, a conductive layer, a reaction zone, one.In the base Conductive layer is formed on plate, which includes the conductive carbon ink for electrochemical reaction to occur, the conduction for conducting electric signal Silver inks and dielectric ink for protecting test paper.Form reaction zone on the conductive layer, reaction zone include biologically active enzyme, The reagents such as conducting medium, high molecular polymer.Interlayer and upper cap rock in being formed on the reaction zone, for being drawn in siphonic process Blood sample to be measured.After blood sample to be measured sucking, with the active material on reaction zone redox can occur for the glucose in blood sample Electric signal is reacted and generates, the size of electric signal is directly proportional to the concentration of glucose in blood sample to be measured, eventually by bio-sensing Device device receives and calculates the signal, converts the signal into blood sample blood sugar concentration to be measured, and be shown on a display.Based on this The bio-sensing test paper of test philosophy further includes blood ketone, uric acid, cholesterol, ferroheme, lactic acid etc., they are exactly at common feature Inexpensively, conveniently, reliably, this quick and cheap detection mode can easily diagnose the illness used in medical care scene and detection is controlled Therapeutic effect can sensitively detect multiple biochemical indicators in different Biomedias.
However, electrochemical biosensor test paper is all manufactured in a manner of batch production at present, it is such as warm in a manufacturing process Degree, humidity, environment cleanliness etc. become because all can caused by otherness between every batch of test paper, which, which all will affect detection, causes to survey Measure the inaccuracy of result.Therefore, sensor is also needed through specific correction parameter corresponding to every batch of test paper between product batch Otherness judge.
In the prior art, it sets code card by pluggable and realizes parameter correction mode, need additionally to increase user's Operating procedure, causes to detect cumbersome in program, and user once slips or be not performing properly the aligning step, then can not obtain To correct testing result.Control information is identified by resistance test value different on parameter recognition component, and parameter is identified The thickness of element top electrode, size requirements are harsh.Therefore, how to simplify or even the person's of eliminating the need for aligning step before measuring, The accuracy for guaranteeing test paper measurement result is for related dealer urgently improvements.
In addition, in order to ensure the proper use of electrochemical biosensor test paper of user's energy, different test paper is matched therewith Biosensor arrangement between often there is specificity, i.e. the feelings of biosensor arrangement that are only matched in insertion of the test paper Measurement movement can be correctly executed under condition.And the designer and manufacturer of electrochemical biosensor test paper often must according to different purposes, Different determinands, different clients and different terminals user produce the test paper of the different biosensor arrangements of a variety of cooperations, with symbol The diversity requirement in market is closed, therefore, is filled with the electricity of all kinds of different producer's marks, design and purpose on the market at present Chemical-biological sensing test-paper and biosensor arrangement.Therefore, how simply and efficiently to recognize that different electrochemica biologicals pass The detection device that sense test paper is matched also urgently is solved not less than for one for the designer and manufacturer of test paper and user Certainly the problem of.
That is the prior art exempts from bar code bio-sensing test paper, is unable to detection device that automatic identification matches and corresponding Correction parameter, and whole measurement process is complicated, is easy to lead to the detection of inaccuracy because of careless omission or operating mistake to user As a result.
Therefore, the prior art still has much room for improvement and develops.
Summary of the invention
In view of the deficiencies in the prior art, the aligning step for the person of eliminating the need for before measuring, enables test paper The biosensor and correction parameter that automatic identification matches with it guarantee that the accuracy of measurement result, the purpose of the present invention exist In providing a kind of special parameter recognition component prepared by cut hole technique, when the bio-sensing test paper with the parameter recognition component When being in contact with detection device, the detection device and corresponding correction parameter that automatic identification matches simplify whole measurement journey Sequence avoids user from leading to the testing result of inaccuracy because of careless omission or operating mistake.
The present invention provides a kind of parameter recognition component, and the parameter recognition component is different by the available multiple groups of cut hole technique Electrode structure, when the bio-sensing test paper with the parameter recognition component is in contact with detection device, automatic identification matches Detection device and corresponding correction parameter.
Technical scheme is as follows:
A kind of parameter recognition component of cut hole technique preparation, is arranged in the test paper and detector for exempting from bar code bio-sensing test paper On device linkage section, wherein the parameter recognition component includes:
One substrate;
One conductive layer, is set on substrate;The conductive layer, which is provided with multiple contacts and can form a variety of different conductings, patrols The electrode structure collected, forms different turn-on logics by way of cut hole;The conductive layer is carbon electrode, silver electrode and gold electrode Any one of;
The electrode structure that the parameter recognition component cut hole can be variously formulated by cut hole technique;
Parameter recognition component includes that at least two kinds of different parameters identify that structural detail, the different structure of parameter recognition component are logical Silk-screen printing, photoetching technique acquisition are crossed, by cut hole, every kind of identification structural detail is capable of forming the shape of a variety of different electrode structures Formula, and each form corresponds to one group of specific correction parameter values;When the test paper and one with special parameter recognition component form When biosensor arrangement connects, which just being capable of the automatic identification biosensor and correction parameter that match with it;
When the bio-sensing test paper with the parameter recognition component is inserted into detecting instrument, the electrode knot of each form Structure can the detecting instrument that matches of automatic identification, while the electrode structure of each form corresponding one group of correction parameter again.
The parameter recognition component, in which: the mode of cut hole includes punching technology, laser cutting parameter.
The parameter recognition component, in which: the figure of the cut hole technique includes circle, triangle, square, polygon Shape, the cut hole technique can be one-off hole-piercing, secondary punching, three times punching etc..
The parameter recognition component, in which: the electrode structure has the connecting terminal of upper end 2, the connection touching of lower end 3 Point is capable of forming 8 kinds of various forms of electrode structures by cut hole;The parameter recognition component 15 is connect with detecting instrument Afterwards, detecting instrument measures the input value of the contact of parameter recognition component bottom end three Yu the contact top Liang Ge, and pre- with detecting instrument If value is compared confirmation;Different according to the batch of biosensor production, response characteristic, parameter recognition component cut hole position is not Together, the input value that instrument detects also can be different;Detecting instrument according to compare confirmation as a result, selecting corresponding technical parameter, most Testing result is provided eventually.
The parameter recognition component, in which: the electrode structure has the connecting terminal of upper end 2, the connection touching of lower end 4 Point is capable of forming 16 kinds of various forms of electrode structures by cut hole;And each electrode structure corresponds to one group and specifically corrects Parameter value, therefore when the test paper with special parameter recognition component form is connect with biosensor arrangement, on number recognition component 6 contacts be in contact with detecting instrument, which just being capable of the automatic identification detecting instrument and correction parameter that match with it;
After the parameter recognition component is connect with detecting instrument, detecting instrument measures the contact of parameter recognition component bottom end four With the input value of the top contact Liang Ge, and confirmation is compared with detecting instrument preset value.According to batch of biosensor production It is secondary, response characteristic is different, parameter recognition component cut hole position is different, and the input value that instrument detects also can be different.Detecting instrument According to confirmation is compared as a result, selecting corresponding technical parameter, testing result is finally provided.
The parameter recognition component, in which: the electrode structure has the connecting terminal of upper end 2, the connection touching of lower end 5 Point, by changing cut hole position, recognition component is able to form 32 kinds/19 kinds/20 kinds/21 kinds/8 kinds various forms of electrodes Structure, and each electrode structure corresponds to one group of specific correction parameter values, therefore working as has special parameter recognition component form When test paper is connect with biosensor arrangement, which just being capable of the detecting instrument that matches with it of automatic identification and correction ginseng Number;
After parameter recognition component of the present invention is connect with detecting instrument, detecting instrument measures parameter recognition component bottom end The input value of five contacts and the contact top Liang Ge, and confirmation is compared with detecting instrument preset value.According to biosensor Batch, the response characteristic of production are different, and parameter recognition component punching position is different, and the input value that instrument detects also can be different. Detecting instrument finally provides testing result according to confirmation is compared as a result, selecting corresponding technical parameter.
The parameter recognition component, in which: the electrode structure has the connecting terminal of upper end 2, the connection touching of lower end 6 Point is capable of forming most 64 kinds of various forms of electrode structures by cut hole.
The parameter recognition component, in which: after parameter recognition component bottom end feeler quantity determines, select corresponding Most quantity M of parameter recognition component structure that final every kind of cut hole mode obtains, cut hole position is obtained not by cut hole mode The most total quantity N of same parameter recognition component structure can be obtained respectively by following formula:
Wherein, n is parameter recognition component bottom end feeler quantity, and i is cut hole quantity.
One kind exempting from bar code bio-sensing test paper, wherein it includes the first insulating layer set gradually, reaction electrode, second Insulating layer, test paper and detecting instrument linkage section;
The bar code bio-sensing test paper of exempting from further includes described in any item parameter recognition components, the parameter recognition component Setting is in test paper and detecting instrument linkage section region;
When bio-sensing test paper is inserted into detecting instrument, each contact on recognition component is in contact with detecting instrument;
After the parameter recognition component is connect with detecting instrument, detecting instrument measures parameter recognition component bottom end three The input value of contact and the contact top Liang Ge, and confirmation is compared with detecting instrument preset value;It is produced according to biosensor Batch, response characteristic it is different, parameter recognition component cut hole position is different, and the input value that instrument detects is different;Detecting instrument According to confirmation is compared as a result, selecting corresponding technical parameter, testing result is finally provided.
A kind of parameter recognition component provided by the present invention and exempt from bar code bio-sensing test paper, eliminates user and measuring Preceding aligning step, the biosensor and correction parameter for so that test paper automatic identification is matched with it, and ensure that measurement As a result accuracy, the present invention provides a kind of special parameter recognition components prepared by cut hole technique, know when with the parameter When the bio-sensing test paper of other element is in contact with detection device, detection device and corresponding correction that automatic identification matches Parameter simplifies entirety process of measurement, user is avoided to lead to the testing result of inaccuracy because of careless omission or operating mistake.
And the present invention has the further advantage that
1, manufacture craft is simple, at low cost.Only it need to change parameter recognition component top electrode by a kind of technique of cut hole Connection type may make up the electrode structure of diversified forms, and detecting instrument and test paper linkage section only need 5~6 contacts Identification can be realized.
2, when electrochemical biosensor test paper provided by the present invention is connect with detecting instrument, pass through ginseng special on test paper Number recognition components can the detecting instrument that matches of automatic identification and one group of correction parameter values corresponding to this batch of test paper, do not need to insert Enter storage card or adjustment detecting instrument setting, reduces detection operating procedure, avoid operator and forget input or input error Password, or it is not inserted into storage card, lead to the situation of testing result mistake.
Detailed description of the invention
Fig. 1 is that the parameter recognition component of the first preferred embodiment exempts from bar code bio-sensing test paper schematic diagram with 5 contacts. (Fig. 1 a exempts from bar code bio-sensing test paper structure lines schematic diagram for the embodiment of the present invention, and Fig. 1 b is exempting from for the embodiment of the present invention Bar code bio-sensing test paper structure effect diagram).
Fig. 2 is the bio-sensing test paper structure schematic diagram that is formed after the parameter recognition component punching with 5 contacts.
Fig. 3 is to connect corner electrode schematic diagram to the different electrode structure formed after parameter recognition component punching.
Fig. 4 exempts from bar code bio-sensing test paper structure effect diagram for second embodiment of the invention.
Fig. 5 is 16 kinds of bio-sensing test paper structure schematic diagrames being formed after the parameter recognition component punching with 6 contacts.
Fig. 6 is 16 kinds of electrode structure forms being formed after the parameter recognition component punching with 6 contacts.
Fig. 7 is to exempt from bar code bio-sensing test paper schematic diagram with 7 contacts.
Fig. 8 is the bio-sensing test paper structure schematic diagram that is formed after the parameter recognition component punching with 7 contacts.
Fig. 9 is 32 kinds of electrode structure forms being formed after the parameter recognition component punching with 7 contacts.
Figure 10 is 20 kinds of bio-sensing test paper structure schematic diagrames being formed after the parameter recognition component punching with 7 contacts.
Figure 11 is 20 kinds of electrode structure forms being formed after the parameter recognition component punching with 7 contacts.
Figure 12 exempts from bar code bio-sensing test paper schematic diagram with 7 contacts for second.
Figure 13 shows for the 19 kinds of bio-sensing test paper structures formed after second of parameter recognition component punching with 7 contacts It is intended to.
Figure 14 is the 19 kinds of electrode structure forms formed after second of parameter recognition component punching with 7 contacts.
Figure 15 exempts from bar code bio-sensing test paper schematic diagram with 7 contacts for the third.
Figure 16 shows for the 21 kinds of bio-sensing test paper structures formed after the third parameter recognition component punching with 7 contacts It is intended to.
Figure 17 is that the third has 21 kinds of electrode structure forms being formed after parameter recognition component punchings of 7 contacts.
Figure 18 is the 4th kind and exempts from bar code bio-sensing test paper schematic diagram with 7 contacts.
Figure 19 shows for the 8 kinds of bio-sensing test paper structures formed after the 4th kind of parameter recognition component punching with 7 contacts It is intended to.
Figure 20 is the 8 kinds of electrode structure forms formed after the 4th kind of parameter recognition component punching with 7 contacts.
Specific embodiment
Below with reference to attached drawing, a specific embodiment of the invention and embodiment are described in detail, described tool Body embodiment only to explain the present invention, is not intended to limit a specific embodiment of the invention.
The embodiment of the present invention provides a kind of special parameter recognition component of cut hole technique preparation, and bar code biology biography is being exempted from setting Feel on the test paper and detecting instrument linkage section of test paper, the parameter recognition component includes:
One substrate;
One conductive layer, is set on substrate;The conductive layer, which is provided with multiple contacts and can form a variety of different conductings, patrols The electrode structure collected, forms different turn-on logics by way of cut hole;The conductive layer is carbon electrode, silver electrode and gold electrode Any one of.
Wherein, conductive layer is set on the substrate;The conductive layer has at least six kinds of special forms, passes through cut hole Mode can form different turn-on logics;The conductive layer can be any one of carbon electrode, silver electrode and gold electrode.
In presently preferred embodiments of the present invention, cut hole technique provided by the present invention includes but is not limited only to punching technology, swashs The figure of light cutting technique, the hole includes but is not limited only to circle, triangle, square, polygon.
In presently preferred embodiments of the present invention, (special) parameter recognition component provided by the present invention includes at least two kinds of differences Parameter identifies structural detail, and by cut hole, every kind of identification structural detail is capable of forming the form of a variety of different electrode structures, and every One form corresponds to one group of specific correction parameter values, therefore when the test paper with special parameter recognition component form and a biology pass When sensor arrangement connects, which just being capable of the automatic identification biosensor and correction parameter that match with it.
The electrode structure that the parameter recognition component cut hole can be variously formulated by a kind of cut hole technique provided by the invention, When bio-sensing test paper is inserted into detecting instrument, the electrode structure of each form being capable of the detector that matches of automatic identification Device, while the electrode structure of each form corresponds to one group of correction parameter again.The figure of the cut hole technique includes but is not limited only to Circle, triangle, square, polygon, the cut hole technique can be one-off hole-piercing, secondary punching, three times punching etc..
In more preferably embodiment, parameter recognition component provided by the present invention includes 2 contacts above, below 3 contacts Identification structural detail, by cut hole, recognition component is capable of forming 8 kinds of different electrode structures, and each electrode structure is corresponding In one group of specific correction parameter values, therefore when the test paper and a biosensor arrangement with special parameter recognition component form connect When connecing, which just being capable of the automatic identification detecting instrument and correction parameter that match with it.
The parameter recognition component of first preferred embodiment of the invention please refers to shown in Fig. 1 a and Fig. 1 b, and bar code life is being exempted from setting On the test paper and detecting instrument linkage section 14 of object sensing test-paper, the contact of bottom end three of the parameter recognition component 15 of the present embodiment (region that label 16 encloses in such as Fig. 1 a, be respectively third contact c, the 4th contact d, the 5th contact e) and the contact upper end Liang Ge (such as The region that label 17 encloses in Fig. 1 a is that the first contact a, the second contact b) pass through Conductive beam connection conducting respectively.Pass through cut hole It can get 8 kinds of various forms of parameter recognition component electrode structures.
Fig. 1 a exempts from bar code bio-sensing test paper structure lines schematic diagram for first embodiment of the invention, and Fig. 1 b is the present invention First embodiment exempts from bar code bio-sensing test paper structure effect diagram;This first embodiment exempts from the examination of bar code bio-sensing Paper comprising the first insulating layer 11, reaction electrode 12, second insulating layer 13, test paper and the detecting instrument linkage section set gradually 14, the parameter recognition component 15 (being also special parameter recognition component) in test paper and 14 region of detecting instrument linkage section is set. Wherein parameter recognition component includes 5 contacts, is the first contact a, the second contact b, third contact c, the 4th contact d, the respectively Five contact e, when bio-sensing test paper is inserted into detecting instrument, 5 contacts on recognition component are in contact with detecting instrument.Fig. 1 b Exempt from bar code bio-sensing test paper structure effect diagram for Fig. 1 a embodiment.
By to the sensing test-paper electrode structure schematic diagram sequentially formed after 15 cut hole of parameter recognition component, as shown in Fig. 2, 8 kinds of sensing test-paper electrode structures of the parameter recognition component with 5 contacts include the first electrode structure 21, second of electrode knot Structure 22, the third electrode structure 23, the 4th kind of electrode structure 24, the 5th kind of electrode structure 25, the 6th kind of electrode structure the 26, the 7th Kind electrode structure 27, the 8th kind of electrode structure 28.Eight kinds of different electrode structures, the corresponding contact of parameter recognition component bottom end three The turn-on logic different from eight kinds of the contact Liang Ge in upper end, corresponding eight kinds of different correction parameters.
As shown in figure 3, display is to connect corner electrode to the different electrode structure formed after 15 punching of parameter recognition component Schematic diagram comprising the first of the first corresponding electrode structure 21 connects angle 31, corresponding second of electrode structure 22 second connects angle 32, the third of the third corresponding electrode structure 23 connects angle 33, corresponding 4th kind of electrode structure 24 the 4th connects angle 34, the corresponding 5th The 5th of kind of electrode structure 25 connects angle 35, corresponding 6th kind of electrode structure 26 the 6th connects angle 36, corresponding 7th kind of electrode structure The 7th of 27 connects angle 37, corresponding 8th kind of electrode structure 28 the 8th connects angle 38.
After parameter recognition component 15 of the present invention is connect with detecting instrument, detecting instrument measures parameter recognition component bottom Holding three contacts, (region that label 16 encloses in such as Fig. 1 a, is third contact c, the 4th contact d, the 5th contact e) and top respectively (region that label 17 encloses in such as Fig. 1 a is the input value of the first contact a, the second contact b) respectively, and and detector for two contacts Device preset value is compared confirmation.Different, the parameter recognition component cut hole position according to the batch of biosensor production, response characteristic Difference is set, the input value that instrument detects also can be different.Detecting instrument is according to comparing confirmation as a result, corresponding technology is selected to join Number, finally provides testing result.
In the embodiment of the present invention, parameter recognition component includes that at least two kinds of different parameters identify structural detail, parameter identification member The different structure of part by silk-screen printing, photoetching technique obtain, by cut hole, every kind of identification structural detail be capable of forming it is a variety of not With the form of electrode structure, and each form corresponds to one group of specific correction parameter values, and the position of cut hole and quantity depend on Each batch test paper characteristic;When the test paper with special parameter recognition component form is connect with a biosensor arrangement, the dress Setting just being capable of the automatic identification biosensor and correction parameter that match with it;
When bio-sensing test paper be inserted into detecting instrument when, the electrode structure of each form can automatic identification match Detecting instrument, while the electrode structure of each form corresponding one group of correction parameter again.
In more preferably embodiment, parameter recognition component 15 provided by the present invention includes 2 contacts above, below 4 touchings The identification structural detail of point, by cut hole, recognition component is capable of forming 16 kinds of different electrode structures, and each electrode structure pair The specific correction parameter values of Ying Yuyi group, therefore when the test paper and biosensor arrangement with special parameter recognition component form connect When connecing, which just being capable of the automatic identification detecting instrument and correction parameter that match with it.
Another preferred embodiment of the present invention please refers to shown in Fig. 4.In the present embodiment, the contact of parameter recognition component bottom end four Conducting is connect by a Conductive beam with the upper end contact Liang Ge.16 kinds of various forms of parameter identification members are obtained by cutting square hole Part electrode structure.
Fig. 4 exempts from bar code bio-sensing test paper structure effect diagram for second embodiment of the invention;This second embodiment Exempt from bar code bio-sensing test paper comprising the first insulating layer 11 for setting gradually, reaction electrode 12, second insulating layer 13, examination Test paper and (special) parameter recognition component in 14 region of detecting instrument linkage section is arranged in paper and detecting instrument linkage section 14 15.Wherein, the parameter recognition component 15 of this second embodiment includes 6 contacts, is the first contact a, the second contact b, the respectively Three contact c, the 4th contact d, the 5th contact e, the 6th contact f, when bio-sensing test paper is inserted into detecting instrument, parameter identification member 6 contacts on part are in contact with detecting instrument.
Fig. 5 is by the sensing test-paper electrode structure schematic diagram formed after 15 cut hole of parameter recognition component comprising, 16 The various forms of electrode structures of kind, electrode structure 501 as shown in Figure 5 to electrode structure 516.16 kinds of electrode structures in this implementation Corresponding 16 kinds of different correction parameters, after detecting instrument is connect with parameter recognition component, pass through leading for detection parameters recognition component Logical state, provides suitable correction parameter.
Fig. 6 is that the different electrode structure formed after cut hole connects corner electrode schematic diagram, can form counter electrode structure 501 connect angle 601~counter electrode structure 516 connect angle 616.It is connect when the correspondence of parameter recognition component connects angle with detecting instrument Afterwards, detecting instrument measurement connects the Continuity signal between corner electrode, is compared according to the Continuity signal of acquisition with preset signal, The corresponding correction parameter of each electrode structure is provided according to comparison result.
After parameter recognition component 15 of the present invention is connect with detecting instrument, detecting instrument measures parameter recognition component bottom The input value of four contacts Yu the contact top Liang Ge is held, and is compared confirmation with detecting instrument preset value.According to bio-sensing Batch, the response characteristic of device production are different, and parameter recognition component cut hole position is different, and the input value that instrument detects can not yet Together.Detecting instrument finally provides testing result according to confirmation is compared as a result, selecting corresponding technical parameter.Specifically, working as parameter When the contact of recognition component bottom end four and all on state in the contact top Liang Ge, the input value that detecting instrument measures is " 1111 ", detecting instrument select correction parameter code " 820 ";When the contact of parameter recognition component bottom end four and the touching of two, top When all nonconducting states of point, the input value that detecting instrument measures is " 0000 ", and detecting instrument selects correction parameter code “620”。
In more preferably embodiment, parameter recognition component provided by the present invention includes 2 contacts above, below 5 contacts Identification structural detail.By changing cut hole position, recognition component is able to be formed 32 kinds/19 kinds/20 kinds/21 kinds/8 kinds not With the electrode structure of form, and each electrode structure corresponds to one group of specific correction parameter values, therefore working as has special parameter knowledge When the test paper of other element versions is connect with biosensor arrangement, which just being capable of the detector that matches with it of automatic identification Device and correction parameter.
Another preferred embodiment of the present invention please refers to shown in Fig. 7.In the present embodiment, the contact of parameter recognition component bottom end five Conducting is connect by a Conductive beam with the upper end contact Liang Ge.By cutting square hole, 32 kinds of various forms of parameter identifications are obtained Element electrode structure.
Fig. 7 exempts from bar code bio-sensing test paper schematic diagram for third embodiment of the invention comprising first set gradually Insulating layer 11, reaction electrode 12, second insulating layer 13, test paper and detecting instrument linkage section 14 are arranged in test paper and detecting instrument (special) parameter recognition component 15 in 14 region of linkage section.Wherein, as shown in fig. 7, the parameter recognition component of the present embodiment 15 include 7 contacts, is the first contact a, the second contact b, third contact c, the 4th contact d, the 5th contact e, the 6th contact respectively F, the 7th contact g, when bio-sensing test paper is inserted into detecting instrument, 7 contacts on recognition component are in contact with detecting instrument.
Fig. 8 is to be illustrated by the sensing test-paper electrode structure formed after 15 cut hole of parameter recognition component to 3rd embodiment Figure can form 32 kinds of electrode structures, 801~electrode structure of electrode structure 832 as shown in Figure 8 with aperture.
Fig. 9 is that the corner electrode that connects of the different electrode structure formed after the parameter recognition component 15 of 3rd embodiment punches is illustrated Figure comprising counter electrode structure 801 connect angle 901~counter electrode structure 832 connect angle 932.Detecting instrument passes through docking The detection at angle obtains different input signals.
After the parameter recognition component 15 of 3rd embodiment of the present invention is connect with detecting instrument, detecting instrument measures ginseng The input value of the number contact of recognition component bottom end five and the contact top Liang Ge, and confirmation is compared with detecting instrument preset value. Different according to the batch of biosensor production, response characteristic, parameter recognition component punching position is different, and instrument detects defeated Entering value also can be different.Detecting instrument finally provides testing result according to confirmation is compared as a result, selecting corresponding technical parameter.Tool Body, when the contact of bottom end five on state all with the contact top Liang Ge, the input value that detecting instrument measures is When " 11111 ", detecting instrument selects correction parameter code " 420 ";When the contact of bottom end five and the contact top Liang Ge are all not When on state, the input value that detecting instrument measures is " 00000 ", and detecting instrument selects correction parameter code " 320 ".
In summary Fig. 1 of the embodiment of the present invention, implementation example figure 4 and implementation example figure 7.When parameter recognition component of the present invention bottom end After feeler quantity determines, suitable cut hole position is selected, the parameter recognition component structure that final every kind of cut hole mode obtains is most Quantity M, the most total quantity N of different parameters recognition component structure obtained by cut hole mode can be obtained respectively by following formula :
Wherein, n is parameter recognition component bottom end feeler quantity, and i is cut hole quantity.
Pass through cut hole mode when feeler increases in allowable range when parameter recognition component bottom end according to above formula The parameter recognition component structure total quantity of acquisition accordingly changes, and can get more parameter identification electrode structures.
Resulting structure quantity after parameter recognition component cut hole of the present invention, in addition to being influenced by bottom end feeler quantity, The position of cut hole and/or cut hole size equally influence whether final actual parameter recognition component number of structures.
Bio-sensing test paper described in Fig. 7 of the present invention is after replacement cut hole shape and cut hole position, parameter recognition component Electrode structure occur corresponding change please refer to shown in Figure 10, Figure 11.After replacing cut hole shape and position, parameter recognition component has Effect electrode structure is reduced to 20 kinds.The signal value on the parameter recognition component top and bottom end contact that detect corresponds respectively to biology 20 groups of correction parameters of sensing test-paper.
Resulting structure form after parameter recognition component cut hole of the present invention, except by bottom end feeler quantity, cut hole Position, the size influence in hole are outer, and the initial configuration of parameter recognition component equally influences whether final parameter recognition component structure Quantity.
Another preferred embodiment of the present invention please refers to shown in Figure 12.In the present embodiment, parameter recognition component bottom end contact with Upper terminal contacts pass through a thin conductive bridge connection.By cut hole technique, have the parameter recognition component of thin conductive bridge structure can Obtain 19 kinds of electrode structures, every kind of electrode structure is please as shown in Figure 13.Test parameter identifies between honest and clean bottom end and upper terminal contacts, bottom The signal value between each contact is held, 19 groups of correction parameters corresponding to bio-sensing test paper.
Figure 12 exempts from bar code bio-sensing test paper schematic diagram for fourth embodiment of the invention, this fourth embodiment exempts from bar code Bio-sensing test paper comprising the first insulating layer 11, reaction electrode 12, second insulating layer 13, test paper and the detection set gradually Instrument linkage section 14, (special) the parameter recognition component 15 being arranged in test paper and 14 region of detecting instrument linkage section.Wherein The parameter recognition component of this fourth embodiment includes 7 contacts, is the first contact a, the second contact b, third contact c, the respectively Four contact d, the 5th contact e, the 6th contact f, the 7th contact g, when bio-sensing test paper is inserted into detecting instrument, on recognition component 7 contacts are in contact with detecting instrument.
Figure 13 is by the sensing test-paper electrode structure schematic diagram formed after 15 cut hole of parameter recognition component comprising electricity Pole 1301~electrode structure of structure 1319.
Figure 14 is that the different electrode structure formed after cut hole connects corner electrode schematic diagram comprising counter electrode structure 1301 Connect angle 1401~counter electrode structure 1319 connect angle 1419.
It is different from Fig. 7 embodiment, parameter recognition component 15 described in this fourth embodiment can get 19 kinds of electricity after cut hole Pole structure, after connecting with detecting instrument, detecting instrument measures the contact of parameter recognition component bottom end five and the contact top Liang Ge Input value is simultaneously compared confirmation with detecting instrument preset value.It is different according to the batch of biosensor production, response characteristic, Parameter recognition component punching position is different, and the input value that instrument detects also can be different.Detecting instrument according to compare confirmation as a result, Corresponding technical parameter is selected, testing result is finally provided.Specifically, when the contact of bottom end five and the top contact Liang Ge are all When on state, when the input value that detecting instrument measures is " 11111 ", detecting instrument selects correction parameter code " 720 ";Work as bottom When holding five contacts and all not on-state in the contact top Liang Ge, the input value that detecting instrument measures is " 00000 ", detection Apparatus selection correction parameter code " 220 ".
Another preferred embodiment of the present invention please refers to shown in Figure 15.In the present embodiment, the touching of parameter recognition component bottom end five Point is connect with two contact of upper end by three thin conductive bridge.By cut hole technique, there are three the ginsengs of thin conductive bridge structure for tool Number recognition component can get 21 kinds of electrode structures.Test the signal value between contact, 21 groups of schools corresponding to bio-sensing test paper Positive parameter.
Figure 15 is that fifth embodiment of the invention exempts from bar code bio-sensing test paper schematic diagram, as shown in figure 15, this 5th implementation Example exempts from bar code bio-sensing test paper comprising the first insulating layer 11 for setting gradually, reaction electrode 12, second insulating layer 13, Test paper and (special) the parameter identification member in 14 region of detecting instrument linkage section is arranged in test paper and detecting instrument linkage section 14 Part 15.Wherein the parameter recognition component of this fifth embodiment includes 7 contacts, is the first contact a, the second contact b, third respectively Contact c, the 4th contact d, the 5th contact e, the 6th contact f, the 7th contact g, when bio-sensing test paper is inserted into detecting instrument, identification 7 contacts on element are in contact with detecting instrument.
Figure 16 is by the sensing test-paper electrode structure schematic diagram formed after 15 cut hole of parameter recognition component comprising electricity Pole 1601~electrode structure of structure 1621.
Figure 17 is that the different electrode structure formed after cut hole connects corner electrode schematic diagram comprising counter electrode structure 1601 Connect angle 1701~counter electrode structure 1621 connect angle 1721.
It is different from Figure 12 embodiment, parameter recognition component 15 described in the present embodiment can get 21 kinds of effectively electricity after cut hole Pole structure, after connecting with detecting instrument, detecting instrument measures the contact of parameter recognition component bottom end five and the contact top Liang Ge Input value, and confirmation is compared with detecting instrument preset value.It is different according to the batch of biosensor production, response characteristic, Parameter recognition component punching position is different, and the input value that instrument detects also can be different.Detecting instrument according to compare confirmation as a result, Corresponding technical parameter is selected, testing result is finally provided.
Another preferred embodiment of the present invention please refers to shown in Figure 18.In the present embodiment, parameter recognition component bottom end has three 5 contacts of a feeler, there are two contacts for upper end tool.By cut hole technique, it can get 8 kinds of various forms of parameter recognition component electricity Pole structure.After the present embodiment bio-sensing test paper is connect with detection device, the feeler of detection parameters recognition component bottom end 5 can be passed through Between connection be connected situation, determine bio-sensing test paper whether contacted with detection device well.
Figure 18 is to exempt from bar code bio-sensing test paper schematic diagram described in sixth embodiment of the invention, this fourth embodiment is exempted from Bar code bio-sensing test paper comprising the first insulating layer 11 for setting gradually, reaction electrode 12, second insulating layer 13, test paper with Detecting instrument linkage section 14, (special) the parameter recognition component 15 being arranged in test paper and 14 region of detecting instrument linkage section. Wherein the parameter recognition component of this fourth embodiment includes 7 contacts, is the first contact a, the second contact b, third contact respectively C, the 4th contact d, the 5th contact e, the 6th contact f, the 7th contact g, when bio-sensing test paper is inserted into detecting instrument, recognition component On 7 contacts be in contact with detecting instrument.
Figure 19 is the sensing test-paper electrode knot by being formed after 15 cut hole of parameter recognition component described in this sixth embodiment Structure schematic diagram comprising 1901~electrode structure of electrode structure 1908.
Figure 20 is that the different electrode structure formed after cut hole connects corner electrode schematic diagram comprising counter electrode structure 1901 Connect angle 2001~counter electrode structure 1908 connect angle 2008.
It is different from Fig. 1 embodiment, parameter recognition component 15 described in the present embodiment includes 7 contacts, is connected with detecting instrument After connecing, detecting instrument measures the input value of the contact of parameter recognition component bottom end five Yu the contact top Liang Ge, and and detecting instrument Preset value is compared confirmation.Different, the parameter recognition component punching position according to the batch of biosensor production, response characteristic Difference, the input value that instrument detects also can be different.Detecting instrument according to comparing confirmation as a result, select corresponding technical parameter, Finally provide testing result.
The parameter recognition component of the embodiment of the present invention, the parameter recognition component can have different structure type, have not Parameter recognition component with structure type can obtain different electrode connection modes by punching or cutting mode.Make the present invention It, can be automatic by parameter recognition component special on test paper when provided electrochemical biosensor test paper is connect with detecting instrument It identifies the detecting instrument to match and one group of correction parameter values corresponding to this batch of test paper, does not need insertion storage card or adjustment inspection Instrument setting is surveyed, detection operating procedure is reduced, operator is avoided and forgets input or input error password, or be not inserted into and deposit Card storage leads to the situation of testing result mistake.
Present invention sets forth a kind of special parameter recognition component based on the preparation of cut hole technique, the parameter recognition component is available In the parameter correction of biosensor test paper.
The parameter recognition component that the present invention states can be there are many different electrode structures after cut hole, it is possible to provide multiple groups are not Same identification signal.When electrochemical biosensor test paper provided by the present invention is connect with detecting instrument, by special on test paper Parameter recognition component can the detecting instrument that matches of automatic identification and one group of correction parameter values corresponding to this batch of test paper, be not required to It is inserted into storage card or adjustment detecting instrument setting, reduces detection operating procedure, operator is avoided and forgets to input or input Bad password, or it is not inserted into storage card, lead to the situation of testing result mistake.
It should be understood that the foregoing is merely illustrative of the preferred embodiments of the present invention, it is not sufficient to limit of the invention Technical solution within the spirit and principles in the present invention, can add according to the above description for those of ordinary skills With increase and decrease, replacement, transformation or improvement, for example, chamfered at the above-mentioned pad corner location to wiring board equally can also be with At corner location applied to solder mask window and circuit etching etc. to wiring board, and all these increases and decreases, replacement, transformation Or improved technical solution, it should all belong to the protection domain of appended claims of the present invention.

Claims (9)

1. a kind of parameter recognition component of cut hole technique preparation, is arranged in the test paper and detecting instrument for exempting from bar code bio-sensing test paper On linkage section, which is characterized in that the parameter recognition component includes:
One substrate;
One conductive layer, is set on substrate;The conductive layer, which is provided with multiple contacts, can form a variety of different turn-on logics Electrode structure forms different turn-on logics by way of cut hole;The conductive layer is in carbon electrode, silver electrode and gold electrode It is any;
The electrode structure that the parameter recognition component cut hole can be variously formulated by cut hole technique;
Parameter recognition component includes that at least two kinds of different parameters identify that structural detail, the different structure of parameter recognition component pass through silk Wire mark brush, photoetching technique obtain, and by cut hole, every kind of identification structural detail is capable of forming the form of a variety of different electrode structures, And each form corresponds to one group of specific correction parameter values;When test paper and a biology with special parameter recognition component form When sensor device connects, which just being capable of the automatic identification biosensor and correction parameter that match with it;
When the bio-sensing test paper with the parameter recognition component is inserted into detecting instrument, the electrode structure of each form is equal Can the detecting instrument that matches of automatic identification, while the electrode structure of each form corresponding one group of correction parameter again.
2. parameter recognition component according to claim 1, it is characterised in that: the mode of cut hole includes punching technology, laser Cutting technique.
3. parameter recognition component according to claim 1, it is characterised in that: the figure of the cut hole technique includes circle, three Angular, square, polygon, the cut hole technique can be one-off hole-piercing, secondary punching, three times punching etc..
4. parameter recognition component according to claim 1, it is characterised in that: the electrode structure has the connection of upper end 2 Contact, the connecting terminal of lower end 3 are capable of forming 8 kinds of various forms of electrode structures by cut hole;The parameter recognition component After 15 connect with detecting instrument, detecting instrument measures the input of the contact of parameter recognition component bottom end three Yu the contact top Liang Ge Value, and confirmation is compared with detecting instrument preset value;Different, the parameter according to the batch of biosensor production, response characteristic Recognition component cut hole position is different, and the input value that instrument detects also can be different;Detecting instrument according to compare confirmation as a result, selection Corresponding technical parameter, finally provides testing result.
5. parameter recognition component according to claim 1, it is characterised in that: the electrode structure has the connection of upper end 2 Contact, the connecting terminal of lower end 4 are capable of forming 16 kinds of various forms of electrode structures by cut hole;And each electrode structure pair The specific correction parameter values of Ying Yuyi group, therefore when the test paper and biosensor arrangement with special parameter recognition component form connect When connecing, 6 contacts on number recognition components are in contact with detecting instrument, which just being capable of the inspection that matches with it of automatic identification Survey instrument and correction parameter;
After the parameter recognition component is connect with detecting instrument, detecting instrument measures the contact of parameter recognition component bottom end four and top The input value of two contacts is held, and is compared confirmation with detecting instrument preset value.According to the batch of biosensor production, sound Answer characteristic different, parameter recognition component cut hole position is different, and the input value that instrument detects also can be different.Detecting instrument according to than Compared with confirmation as a result, selecting corresponding technical parameter, testing result is finally provided.
6. parameter recognition component according to claim 1, it is characterised in that: the electrode structure has the connection of upper end 2 Contact, the connecting terminal of lower end 5, by changing cut hole position, recognition component is able to form 32 kinds/19 kinds/20 kinds/21 / 8 kinds of various forms of electrode structures of kind, and each electrode structure corresponds to one group of specific correction parameter values, therefore working as has spy When determining the test paper of parameter recognition component form and being connect with biosensor arrangement, the device just can automatic identification match with it Detecting instrument and correction parameter;
After parameter recognition component of the present invention is connect with detecting instrument, detecting instrument measures parameter recognition component bottom end five The input value of contact and the contact top Liang Ge, and confirmation is compared with detecting instrument preset value.It is produced according to biosensor Batch, response characteristic it is different, parameter recognition component punching position is different, and the input value that instrument detects also can be different.Detection Instrument finally provides testing result according to confirmation is compared as a result, selecting corresponding technical parameter.
7. parameter recognition component according to claim 1, it is characterised in that: the electrode structure has the connection of upper end 2 Contact, the connecting terminal of lower end 6 are capable of forming most 64 kinds of various forms of electrode structures by cut hole.
8. parameter recognition component according to claim 1, it is characterised in that: parameter recognition component bottom end feeler quantity After determination, corresponding cut hole position is selected, it is most quantity M of parameter recognition component structure that final every kind of cut hole mode obtains, logical Crossing the most total quantity N of different parameters recognition component structure that cut hole mode obtains can be obtained respectively by following formula:
Wherein, n is parameter recognition component bottom end feeler quantity, and i is cut hole quantity.
9. one kind exempts from bar code bio-sensing test paper, which is characterized in that it include the first insulating layer set gradually, reaction electrode, Second insulating layer, test paper and detecting instrument linkage section;
The bar code bio-sensing test paper of exempting from further includes the described in any item parameter recognition components of claim 1-8, the parameter Recognition component setting is in test paper and detecting instrument linkage section region;
When bio-sensing test paper is inserted into detecting instrument, each contact on recognition component is in contact with detecting instrument;
After the parameter recognition component is connect with detecting instrument, detecting instrument measures the contact of parameter recognition component bottom end three With the input value of the top contact Liang Ge, and confirmation is compared with detecting instrument preset value;According to batch of biosensor production It is secondary, response characteristic is different, the input value that parameter recognition component cut hole position is different, and instrument detects is different;Detecting instrument according to Compare confirmation as a result, selecting corresponding technical parameter, finally provides testing result.
CN201810813989.6A 2018-07-23 2018-07-23 A kind of parameter recognition component and exempt from bar code bio-sensing test paper Pending CN109142484A (en)

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Application publication date: 20190104