CN205874451U - Artificial blood vessel's cultivation and function detecting device - Google Patents
Artificial blood vessel's cultivation and function detecting device Download PDFInfo
- Publication number
- CN205874451U CN205874451U CN201620834134.8U CN201620834134U CN205874451U CN 205874451 U CN205874451 U CN 205874451U CN 201620834134 U CN201620834134 U CN 201620834134U CN 205874451 U CN205874451 U CN 205874451U
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- blood vessel
- cultivation
- artificial blood
- connecting tube
- perfusion post
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Abstract
The utility model discloses an artificial blood vessel's cultivation and function detecting device, it includes the stock solution bottle, impels pump, vascular perfusion post, runing rest, rotary actuator and waste liquid receiving flask, the stock solution bottle is linked together through the entry end of first connecting pipe with vascular perfusion post, the propulsion pump is located on the first connecting pipe, blood vessel perfusion post is used for placing the artificial blood vessel who treats cultivation or detection, blood vessel perfusion post set up in on the runing rest. The press handle type spring clamp is advantageous in tha, the utility model discloses a cover be used for external vascular perfusion train with the device of function test, for the artificial blood vessel in vitro of biology manufacturing provides more suitable isolated plant, the process that developments were trained will increase the endothelial cells field planting, endothelium formation endothelial more easily under the effect of shearing force. Through the work that impels the pump for culture solution in the middle of the stock solution bottle is continuous via vascular perfusion post flow direction waste liquid receiving flask, thereby forms a circulation, simulates hematal living environment, conveniently carries out artificial blood vessel's cultivation and detection.
Description
Technical field
This utility model belongs to medical experiment field, especially relates to cultivation and the Function detection dress of a kind of artificial blood vessel
Put.
Background technology
3D printing technique is gradually extensive in organizational project application, and 3D printing organ is expected by even people, but
It is that this process still has many difficulties to need to overcome, such as, the vascularization of histoorgan.Either tissue or organ, all
Need vascular system supply nutrition and excretion refuse.Therefore, vascularization technology is the difficult problem that Organ printing must solve, artificial blood
Pipe provides possibility for solving this difficulty.The platform of one suitable in-vitro evaluation biology manufacture vascular function will may consequently contribute to
Advance the progress printing organ vascularization.
Utility model content
The purpose of this utility model is to provide cultivation and the function detection device of artificial blood vessel, it is possible to solve the problems referred to above
In at least one.
According to an aspect of the present utility model, it is provided that the cultivation of artificial blood vessel and function detection device, it includes storage
Liquid bottle, propelling pump, blood vessel perfusion post, runing rest, rotation motor and waste collection bottle,
Described liquid containing bottle is connected by the arrival end of the first connecting tube with blood vessel perfusion post, and described propelling pump is located at described
In first connecting tube；
Described blood vessel perfusion post is for placing the artificial blood vessel waiting to cultivate or detect, and described blood vessel perfusion post is arranged at described
On runing rest, described rotation motor drives described blood vessel perfusion post to carry out rotation process on runing rest；
The other end of described blood vessel perfusion post is connected with waste collection bottle by the second connecting tube.
It provides the benefit that, this utility model is a set of cultivation for extracorporeal blood vessel perfusion and the device of Function detection, for
The biological artificial blood vessel's in vitro study manufactured provides more suitably special purpose device, and the process of dynamic cultivation will increase endotheliocyte
Field planting, is more prone to endothelialization under the effect of shearing force and forms blood vessel endothelium.
In the middle of this utility model, by advancing the work of pump so that the culture fluid in the middle of liquid containing bottle is constantly via blood vessel
Perfusion post flows to waste collection bottle, thus forms a circulation, the living environment of simulated blood vessel, conveniently carries out the training of artificial blood vessel
Support and detection.
Runing rest is set, it is ensured that whole blood vessel perfusion post is in the middle of a process rotated, and so can protect
The upper and lower surface of card artificial blood vessel all can sufficiently touch culture medium.Do not have a part of blood vessel and be immersed in culture medium for a long time
In the middle of, and another part blood vessel can not reach culture medium for a long time, thus affect the normal cultivation of blood vessel, also influence whether
The accuracy of the data detected eventually.
In the middle of some embodiments, the two ends of described blood vessel perfusion post are equipped with rotation seal joint, revolve described in two ends
Turn seal nipple to be connected with described first connecting tube and the second connecting tube respectively.It provides the benefit that, arranges rotatory sealing and connects
After Tou, on the one hand can ensure that blood vessel perfusion post can be connected with first connecting tube at two ends and the second connecting tube, the opposing party
Face can ensure that whole blood vessel perfusion post is rotary, it is ensured that blood vessel is fully contacted with culture medium.
In the middle of some embodiments, described first connecting tube being additionally provided with filter, described filter is 0.22 μm
Pin type filter.It provides the benefit that, after arranging filter, can filter out the impurity or antibacterial being mixed in the middle of culture medium, anti-
Only Impact factor is to the normal cultivation of artificial blood vessel, and the accuracy of the data of last Function detection.
In the middle of some embodiments, described blood vessel perfusion post is provided with thief hole.It provides the benefit that, by sampling
Hole, in that context it may be convenient to extract the culture medium in the middle of blood vessel perfusion post or vascular tissue, thus analyze accordingly and detect.
In the middle of some embodiments, described second connecting tube is provided with pressure and resistivity detection hole.Its beneficial effect
It is, by this detection hole, in that context it may be convenient to carry out the detection of pressure and resistivity.
In the middle of some embodiments, described first connecting tube is provided with pressure-regulating valve.It provides the benefit that, due to whole
Individual device is the blood circulation of a relative closure, after arranging pressure-regulating valve, in that context it may be convenient to regulate in whole device
The pressure condition in portion, it is ensured that cultivation is normally carried out with Function detection.
In the middle of some embodiments, described blood vessel perfusion post is groove-like structure, described blood vessel perfusion post include kerve and
Groove lid, described kerve is provided with inlays recess, inlays in recess, pass through between described kerve and groove lid described in the embedding of described groove lid
Lock screw fastens, described in inlay and be additionally provided with elastic rubber fitting between recess and described groove lid.It provides the benefit that, will fastening
Position be arranged between kerve and groove lid, the position of sealing is arranged on and inlays between recess and groove lid, so can ensure that
Lock screw will not touch the inside culture environment of whole device, such that it is able to prevent the generation polluted.
In the middle of some embodiments, the two ends of described rotation seal joint have inner joint and external tapping respectively, described interior
Interface for to be detected or cultivate artificial blood vessel carry out sew up airtight connection, described external tapping for the first connecting tube or
Second connecting tube carries out airtight connection.It provides the benefit that, the difference of the object connected as required, selects corresponding joint,
Can ensure that the stability of the connection of whole device.
In the middle of some embodiments, the bottom of the described liquid containing bottle of end insertion of described first connecting tube, described second
The end of connecting tube is positioned at the bottleneck of waste collection bottle.It provides the benefit that, the second connecting tube is arranged on the bottle of waste collection bottle
Mouthful, it is the phenomenon in order to prevent suck-back.
Accompanying drawing explanation
Fig. 1 is cultivation and the structure principle chart of function detection device of the artificial blood vessel of this utility model embodiment；
Fig. 2 is the blood vessel perfusion post knot in the cultivation of the artificial blood vessel of this utility model embodiment and function detection device
Structure schematic diagram.
Detailed description of the invention
1 to 2 pair of this utility model is described in further detail below in conjunction with the accompanying drawings.
As it is shown in figure 1, the cultivation of the artificial blood vessel of embodiment of the present utility model and function detection device, including liquid storage
Bottle 1, propelling pump 2, blood vessel perfusion post 3, runing rest 4, rotation motor 5 and waste collection bottle 6, described liquid containing bottle 1 is by first
Connecting tube 7 is connected with the arrival end of blood vessel perfusion post 3, and described propelling pump 2 is located in described first connecting tube 7；Described blood vessel
Perfusion post 3 is for placing the artificial blood vessel waiting to cultivate or detect, and described blood vessel perfusion post 3 is arranged on described runing rest 4, institute
Stating rotation motor 5 drives described blood vessel perfusion post 3 to carry out rotation process on runing rest 4；Another of described blood vessel perfusion post 3
End is connected with waste collection bottle 6 by the second connecting tube 8.
This utility model is a set of to cultivate and the device of Function detection for extracorporeal blood vessel perfusion, for biology manufacture artificial
Blood vessel in vitro study provides more suitably special purpose device, and the process of dynamic cultivation will increase endotheliocyte field planting, in shearing force
Effect under be more prone to endothelialization formed blood vessel endothelium.
In the middle of this utility model, by advancing the work of pump 2 so that the culture fluid in the middle of liquid containing bottle 1 is constantly via blood
Pipe perfusion post 3 flows to waste collection bottle 6, thus forms a circulation, the living environment of simulated blood vessel, conveniently carries out artificial blood vessel
Cultivation and detection.
Runing rest 4 is set, it is ensured that whole blood vessel perfusion post 3 is in the middle of a process rotated, the most permissible
Ensure that the upper and lower surface of artificial blood vessel all can sufficiently touch culture medium.Do not have a part of blood vessel and be immersed in cultivation for a long time
In the middle of base, and another part blood vessel can not reach culture medium for a long time, thus affects the normal cultivation of blood vessel, influences whether yet
The accuracy of the data eventually detected.
Be equipped with rotation seal joint 9 at the two ends of blood vessel perfusion post 3, rotation seal joint 9 described in two ends respectively with institute
State the first connecting tube 7 and the second connecting tube 8 is connected.After rotation seal joint 9 is set, on the one hand can ensure that blood vessel perfusion post
3 can be connected with first connecting tube 7 at two ends and the second connecting tube 8, on the other hand can ensure that whole blood vessel perfusion post 3 is
Rotary, it is ensured that blood vessel is fully contacted with culture medium.
Meanwhile, being additionally provided with filter 10 in described first connecting tube 7, described filter 10 is the pin type filter of 0.22 μm
Device.After filter 10 is set, the impurity or antibacterial being mixed in the middle of culture medium can be filtered out, prevent Impact factor from arriving artificial blood
The normal cultivation of pipe, and the accuracy of the data of last Function detection.
Described blood vessel perfusion post 3 is provided with thief hole 11.It provides the benefit that, by thief hole 11, in that context it may be convenient to
Extract the culture medium in the middle of blood vessel perfusion post 3 or vascular tissue, thus analyze accordingly and detect.Described second even
Adapter 8 is provided with pressure and resistivity detection hole 12.It provides the benefit that, by this detection hole, in that context it may be convenient to carry out pressure
Detection with resistivity.Described first connecting tube 7 is provided with pressure-regulating valve 13.It provides the benefit that, due to whole device
It is the blood circulation of a relative closure, after pressure-regulating valve 13 is set, in that context it may be convenient to regulate within whole device
Pressure condition, it is ensured that cultivation is normally carried out with Function detection.
As in figure 2 it is shown, described blood vessel perfusion post 3 is groove-like structure in the middle of this utility model, described blood vessel perfusion post 3 includes
Kerve 14 and groove lid 15, described kerve 14 is provided with inlays recess 16, described groove lid 15 embed described in inlay in recess 16, described
Fastened by lock screw 17 between kerve 14 and groove lid 15, described in inlay and be additionally provided with between recess 16 and described groove lid 15
Elastic rubber fitting 18.It provides the benefit that, is arranged between kerve 14 and groove lid 15 position of fastening, is arranged the position sealed
Inlaying between recess 16 and groove lid 15, so can ensure that lock screw 17 will not touch the inside cultivation ring of whole device
Border, such that it is able to prevent the generation polluted.
Meanwhile, inner joint 19 and external tapping 20, described inner joint 19 is had to use respectively at the two ends of described rotation seal joint 9
In carrying out sewing up airtight connection with artificial blood vessel that is to be detected or that cultivate, described external tapping 20 is used for and the first connecting tube 7 or the
Two connecting tubes 8 carry out airtight connection.It provides the benefit that, the difference of the object connected as required, selects corresponding joint, can
To ensure the stability of the connection of whole device.
In the middle of this utility model, the bottom of described liquid containing bottle 1, described second connecting tube 8 are inserted in the end of the first connecting tube 7
End be positioned at the bottleneck of waste collection bottle 6.It provides the benefit that, the second connecting tube 8 is arranged on the bottleneck of waste collection bottle 6,
It it is the phenomenon in order to prevent suck-back.
Above is only preferred implementation of the present utility model, it is noted that for those of ordinary skill in the art
For, on the premise of creating design without departing from this utility model, it is also possible to make some deformation and improvement, these broadly fall into this
The protection domain of utility model.
Claims (9)
1. the cultivation of artificial blood vessel and function detection device, it is characterised in that include liquid containing bottle (1), advance pump (2), blood vessel to fill
Fluidization tower (3), runing rest (4), rotation motor (5) and waste collection bottle (6),
Described liquid containing bottle (1) is connected by the arrival end of the first connecting tube (7) with blood vessel perfusion post (3), described propelling pump (2)
It is located on described first connecting tube (7)；
Described blood vessel perfusion post (3) is for placing the artificial blood vessel waiting to cultivate or detect, and described blood vessel perfusion post (3) is arranged at institute
Stating on runing rest (4), described rotation motor (5) drives described blood vessel perfusion post (3) to carry out rotating behaviour on runing rest (4)
Make；
The other end of described blood vessel perfusion post (3) is connected with waste collection bottle (6) by the second connecting tube (8).
The cultivation of artificial blood vessel the most according to claim 1 and function detection device, it is characterised in that described blood vessel perfusion
The two ends of post (3) are equipped with rotation seal joint (9), rotation seal joint (9) described in two ends respectively with described first connecting tube
And the second connecting tube (8) is connected (7).
The cultivation of artificial blood vessel the most according to claim 1 and function detection device, it is characterised in that described first connects
Being additionally provided with filter (10) on pipe (7), described filter (10) is the pin type filter of 0.22 μm.
The cultivation of artificial blood vessel the most according to claim 1 and function detection device, it is characterised in that described blood vessel perfusion
Post (3) is provided with thief hole (11).
The cultivation of artificial blood vessel the most according to claim 1 and function detection device, it is characterised in that described second connects
Pipe (8) is provided with pressure and resistivity detection hole (12).
The cultivation of artificial blood vessel the most according to claim 1 and function detection device, it is characterised in that described first connects
Pipe (7) is provided with pressure-regulating valve (13).
The cultivation of artificial blood vessel the most according to claim 1 and function detection device, it is characterised in that described blood vessel perfusion
Post (3) is groove-like structure, and described blood vessel perfusion post (3) includes kerve (14) and groove lid (15), and described kerve (14) is provided with edge
Embedding recess (16), described groove lid (15) embed described in inlay recess (16) in, pass through between described kerve (14) and groove lid (15)
Lock screw (17) fastens, described in inlay and between recess (16) and described groove lid (15), be additionally provided with elastic rubber fitting (18).
The cultivation of artificial blood vessel the most according to claim 1 and function detection device, it is characterised in that described rotatory sealing
The two ends of joint (9) have inner joint (19) and external tapping (20) respectively, and described inner joint (19) is for to be detected or cultivation
Artificial blood vessel carries out sewing up airtight connection, and described external tapping (20) is for carrying out with the first connecting tube (7) or the second connecting tube (8)
Airtight connection.
The cultivation of artificial blood vessel the most according to claim 1 and function detection device, it is characterised in that described first connects
The bottom of described liquid containing bottle (1) is inserted in the end of pipe (7), and the end of described second connecting tube (8) is positioned at waste collection bottle (6)
Bottleneck.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620834134.8U CN205874451U (en) | 2016-08-03 | 2016-08-03 | Artificial blood vessel's cultivation and function detecting device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620834134.8U CN205874451U (en) | 2016-08-03 | 2016-08-03 | Artificial blood vessel's cultivation and function detecting device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205874451U true CN205874451U (en) | 2017-01-11 |
Family
ID=57702014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620834134.8U Expired - Fee Related CN205874451U (en) | 2016-08-03 | 2016-08-03 | Artificial blood vessel's cultivation and function detecting device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205874451U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116769598A (en) * | 2023-07-24 | 2023-09-19 | 柔脉医疗(深圳)有限公司 | In-vitro culture device for artificial tissue |
-
2016
- 2016-08-03 CN CN201620834134.8U patent/CN205874451U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116769598A (en) * | 2023-07-24 | 2023-09-19 | 柔脉医疗(深圳)有限公司 | In-vitro culture device for artificial tissue |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170111 Termination date: 20170803 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |