CN205516608U - Supplementary enzyme process of ultrasonic wave draws enterokinase device - Google Patents
Supplementary enzyme process of ultrasonic wave draws enterokinase device Download PDFInfo
- Publication number
- CN205516608U CN205516608U CN201620186173.1U CN201620186173U CN205516608U CN 205516608 U CN205516608 U CN 205516608U CN 201620186173 U CN201620186173 U CN 201620186173U CN 205516608 U CN205516608 U CN 205516608U
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- China
- Prior art keywords
- jar
- shaft
- enterokinase
- supersonic generator
- extraction pot
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 238000000034 method Methods 0.000 title claims abstract description 27
- 108010013369 Enteropeptidase Proteins 0.000 title claims abstract description 15
- 102100029727 Enteropeptidase Human genes 0.000 title claims abstract description 15
- 230000008569 process Effects 0.000 title claims abstract description 15
- 108090000790 Enzymes Proteins 0.000 title claims abstract description 14
- 102000004190 Enzymes Human genes 0.000 title claims abstract description 14
- 238000003756 stirring Methods 0.000 claims abstract description 22
- 239000000284 extract Substances 0.000 claims abstract description 14
- 239000002893 slag Substances 0.000 claims abstract description 6
- 238000000605 extraction Methods 0.000 claims description 45
- 238000002604 ultrasonography Methods 0.000 claims description 19
- BGOFCVIGEYGEOF-UJPOAAIJSA-N helicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1C=O BGOFCVIGEYGEOF-UJPOAAIJSA-N 0.000 claims description 6
- 229960000074 biopharmaceutical Drugs 0.000 abstract 1
- 239000002904 solvent Substances 0.000 description 8
- 238000000638 solvent extraction Methods 0.000 description 6
- 238000002137 ultrasound extraction Methods 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 101100298222 Caenorhabditis elegans pot-1 gene Proteins 0.000 description 3
- 229910000831 Steel Inorganic materials 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000003834 intracellular effect Effects 0.000 description 3
- 239000010959 steel Substances 0.000 description 3
- 210000002421 cell wall Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 108010059378 Endopeptidases Proteins 0.000 description 1
- 102000005593 Endopeptidases Human genes 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 102000018690 Trypsinogen Human genes 0.000 description 1
- 108010027252 Trypsinogen Proteins 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002183 duodenal effect Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000008361 herbal raw material Substances 0.000 description 1
- 210000003701 histiocyte Anatomy 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Extraction Or Liquid Replacement (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The utility model discloses a supplementary enzyme process of ultrasonic wave draws enterokinase device in bio -pharmaceuticals field. Including drawing jar, supersonic generator and agitator, supersonic generator sets up at the top of drawing the jar, and the agitator is located and draws the jar, draws tank deck portion and is equipped with the supersonic generator entry, and supersonic generator's working head gets into from entering the mouth and draws the jar, draws the working head that tank deck portion was provided with two supersonic generator, along transversely being provided with the (mixing) shaft that has stirring vane, the (mixing) shaft passes through agitator motor and drives the (mixing) shaft in extracting the jar, extract tank bottoms portion open there is the slag notch, jar circulating inlet, the bottom is equipped with the filter screen in extracting jar, extracts jar lateral wall and opens and have a jar loop exit, jar loop exit is connected with gaseous agitator through pipe connection, a jar circulating inlet with the circulating pump export through pipe connection, jar circulating inlet with the circulating pump entry. The utility model has the advantages of efficient, equipment structure simple and maintain convenient.
Description
Technical field
This utility model relates to a kind of ultrasonic assistant enzyme process of field of biological pharmacy and extracts enterokinase device.
Background technology
Enterokinase is present in the duodenal mucosa of higher mammal, is to make trypsinogen hydrolysis become activity pancreas
The endopeptidase of protease.This reacts the ratio fast decades of times of activation caused by trypsin self catalyst, solvent extraction
Method is to extract effective components in plants most common method.Solvent extraction method is according to compositions various in plant in a solvent
Dissolution properties, selects big to active ingredient solubility, the solvent little to need not dissolved element dissolubility, thus will effectively become
Divide the method being dissolved out in medical material tissue.When solvent is added in herbal raw material (need to suitably pulverize), solvent is owing to expanding
Dissipate, osmosis gradually passes through cell wall and penetrates into intracellular, has dissolved solable matter, and has caused the concentration of intraor extracellular
Difference, the most intracellular concentrated solution is constantly to external diffusion, and solvent the most constantly enters in medical material histiocyte, the most repeatedly comes and goes,
During until intraor extracellular solution concentration reaches dynamic equilibrium, this saturated solution is leached, continues repeatedly to add novel solvent, so that it may
So that required composition is bordering on complete dissolution or big portion's dissolution.In order to strengthen extraction efficiency, the extraction of raising active component
Rate, this process, it is generally required to long-time heating, therefore, is extracted energy consumption big, but also can be made some thermal instabilitys, the Yishui River
Solve or the effective ingredient recurring structure change of oxidation, reduce use value.
Theory and experimentation in recent years show, be aided with ultrasonic technique and can significantly reduce extraction in solvent extraction method
Time, reduction heating-up temperature, the extraction ratio of raising effective ingredient.Ultrasonic wave energy accelerates the extraction process of effective components in plants,
It main reason is that: ultrasound wave is propagated in a liquid, causes the compression alternately of solution particle and extension so that it is obtain certain
Acceleration, thus accelerate diffusion and osmosis, accelerate the extraction process of effective components in plants；Ultrasound wave is at liquid
The cavitation caused in body, produces powerful impulsive force and shearing force to plant cell, makes plant cell wall breaking, make plant
Intracellular effective ingredient separates out rapidly and is dissolved in solvent.
The beneficial effect extracted effective ingredients in plant in view of ultrasound wave, gradually sends out on original solvent extraction equipment
Open up a ultrasound-enhanced solvent extraction equipment of class.What it was main be structurally characterized in that set up on original solvent extraction equipment super
Acoustic wave transducer.Its principal mode has three kinds, and one is directly to be adhered to/be welded on by transducer on extraction vessel wall, two be by
The work head of transducer is inserted directly in extraction vessel, and three is by direct for the ultrasound wave vibration plate that is welded with multiple ultrasonic transducer
Put in extraction vessel.Its ultrasonic frequency includes single-frequency, double frequency, even three frequencies.Currently, the master of Chinese medicine extractor
Pot type ultrasonic extraction equipment to be had and continuous flow upstream tubular ultrasonic ripple extraction equipment.For pot type ultrasonic extraction equipment, logical
Often being bonded on container bottom and sidewall by ultrasonic transducer, but tank skin is the thickest, the ultrasonic acoustic loss of energy is too big, in distance
Ultrasonic clear area can be formed, so that total extraction effect is unsatisfactory in the biggest segment distance at tank center；Also set
Meter person be aided with on the basis of the said equipment throw-in type and plug-in type ultrasonic oscillator design, but owing to extracting
The volume of tank is bigger so that the ultrasonic power that will match with tank volume is too big, and equipment cost and manufacture difficulty are too big, with
Time, pot type ultrasonic extraction equipment is also easy to material depositional phenomenon.For continuous flow upstream tubular ultrasonic ripple extraction equipment,
It uses spiral propeller to advance material, and the direction of motion of material is contrary with the flow direction of solvent, it is possible to achieve add continuously
Material, improves production efficiency；This ultrasonic extraction device is bulky, and ultrasonic oscillator is the most all adhered on chamber wall, although
Employ substantial amounts of piezoelectric transducer, but the ultrasound wave sound intensity owing to producing is low so that extraction time is longer.In a word, existing
All there is the lack of homogeneity that the shortcoming that some are universal, such as ultrasound wave are distributed in extracting solution, ultrasound wave in ultrasonic extraction equipment
Intensity not enough etc. so that extraction efficiency and the effect of existing ultrasonic extraction device are the most not ideal enough.
Summary of the invention
The purpose of the present utility model is to overcome the deficiencies in the prior art, it is provided that the ultrasound wave that a kind of extraction efficiency is high
Extraction element.
The present utility model is realized by below scheme:
A kind of ultrasonic assistant enzyme process extracts enterokinase device, including extraction pot, supersonic generator and agitator, ultrasonic
Wave producer is arranged on the top of extraction pot, and agitator is positioned at extraction pot, it is characterised in that: extraction pot top is provided with ultrasonic
Wave producer entrance, the work head of supersonic generator enters extraction pot from entrance, and extraction pot top is provided with two ultrasound wave
The work head of generator；Being horizontally arranged with the shaft with stirring vane in extraction pot, shaft passes through stirring motor
Driving shaft, have slag notch, tank loop head bottom extraction pot, extraction pot inner bottom part is provided with drainage screen, extraction pot sidewall
Having tank loop exit, tank loop exit is connected by pipeline with pump entry, and tank loop head passes through with circulating-pump outlet
Pipeline connects, and tank loop head is connected with gas blender.；Make technique scheme further to optimize, described ultrasound wave
Generator is magnetostriction type ultrasonic transducer, and frequency is 40KHZ；Make technique scheme further to optimize, described
It is each provided with the work head of a supersonic generator on the left and right end face at extraction pot top, technique scheme is made into one
The optimization of step, the stirring vane of described agitator is double-helix, and shaft arranges one or more pieces spiral helicine paddles
Sheet；Making technique scheme further to optimize, described spiral helicine stirring vane is wound around the angle of shaft and is less than or equal to
330 °, when there being the stirring vane of multi-slice spiral shape, the angle of every spiral helicine stirring vane winding shaft is equal；Right
Technique scheme is made further to optimize, and the stirring vane of described shaft is plane, the stirring vane that multi-disc is plane
Being axially arranged on shaft successively, and be staggered mutually in the circumference of shaft, the plane of stirring vane is with super
The direction of propagation of the ultrasound wave that sonic generator sends is parallel；Making technique scheme further to optimize, ultrasound wave occurs
The bottom of device is provided with drainage screen, equipped with permanent-magnet block on drainage screen.
The present utility model has the advantages that
1. the ultrasound wave sound intensity is high, improves extraction efficiency.
2. agitating device adds the diffusion of fast solute.
3. device structure is simple, therefore, plant maintenance, easy to maintenance.
Fig. 1 is that ultrasonic assistant enzyme process extracts enterokinase device schematic diagram schematic diagram.
In figure: extraction pot 1, supersonic generator entrance 2, charging aperture 3, supersonic generator entrance 4, permanent-magnet block
5, drainage screen 6, air-flow stirring device 7, tank loop head 8, slag notch 9, circulating pump 10, tank loop exit 11, steel mesh 12.
Detailed description of the invention
Below in conjunction with concrete drawings and Examples, the utility model is described in further detail.
It as shown is ultrasonic assistant enzyme process and extracts enterokinase device schematic diagram, including extraction pot 1, supersonic generator
Entrance 2, charging aperture 3, supersonic generator entrance 4, permanent-magnet block 5, drainage screen 6, air-flow stirring device 7, tank loop head
8, slag notch 9, circulating pump 10, tank loop exit 11, steel mesh 12.
Extraction pot 1 top has supersonic generator entrance and charging aperture, has slag notch and tank follows bottom extraction pot
Ring entrance, extraction pot inner bottom part is provided with drainage screen, and equipped with permanent-magnet block on drainage screen bottom ultrasonic device, extraction pot sidewall is opened
Having tank loop exit, be provided with steel mesh in tank loop exit, tank loop exit is connected by pipeline with pump entry, and tank circulates
Entrance is connected by pipeline with circulating-pump outlet, and tank loop head is connected with gas blender.
Claims (7)
1. ultrasonic assistant enzyme process extracts an enterokinase device, including extraction pot, supersonic generator and agitator, ultrasound wave
Generator is arranged on the top of extraction pot, and agitator is positioned at extraction pot, it is characterised in that: extraction pot top is provided with ultrasound wave and sends out
Raw device entrance, the work head of supersonic generator enters extraction pot from entrance, and extraction pot top is provided with two ultrasound wave and occurs
The work head of device；Being horizontally arranged with the shaft with stirring vane in extraction pot, shaft is driven by stirring motor
Shaft, has slag notch, tank loop head bottom extraction pot, extraction pot inner bottom part is provided with drainage screen, and extraction pot sidewall has
Tank loop exit, tank loop exit is connected by pipeline with pump entry, and tank loop head and circulating-pump outlet pass through pipeline
Connecting, tank loop head is connected with gas blender.
Ultrasonic assistant enzyme process the most according to claim 1 extracts enterokinase device, it is characterised in that: described ultrasound wave is sent out
Raw device is magnetostriction type ultrasonic transducer, and frequency is 40KHZ.
Ultrasonic assistant enzyme process the most according to claim 1 extracts enterokinase device, it is characterised in that: described extraction tank deck
The work head of a supersonic generator it is each provided with on the left and right end face in portion.
Ultrasonic assistant enzyme process the most according to claim 1 extracts enterokinase device, it is characterised in that: described agitator
Stirring vane is double-helix, and shaft arranges one or more pieces spiral helicine stirring vanes.
Ultrasonic assistant enzyme process the most according to claim 4 extracts enterokinase device, it is characterised in that: described spiral helicine
Stirring vane is wound around the angle of shaft and is less than or equal to 330 °, and when there being the stirring vane of multi-slice spiral shape, every spiral helicine
The angle that stirring vane is wound around shaft is equal.
Ultrasonic assistant enzyme process the most according to claim 1 extracts enterokinase device, it is characterised in that: described shaft
Stirring vane is plane, and the plane stirring vane of multi-disc is axially arranged on shaft successively, and at shaft
Being staggered mutually in circumference, the direction of propagation of the ultrasound wave that the plane of stirring vane sends with supersonic generator is parallel.
Ultrasonic assistant enzyme process the most according to claim 1 extracts enterokinase device, it is characterised in that: supersonic generator
Bottom be provided with drainage screen, equipped with permanent-magnet block on drainage screen.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620186173.1U CN205516608U (en) | 2016-03-11 | 2016-03-11 | Supplementary enzyme process of ultrasonic wave draws enterokinase device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620186173.1U CN205516608U (en) | 2016-03-11 | 2016-03-11 | Supplementary enzyme process of ultrasonic wave draws enterokinase device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205516608U true CN205516608U (en) | 2016-08-31 |
Family
ID=56781482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620186173.1U Expired - Fee Related CN205516608U (en) | 2016-03-11 | 2016-03-11 | Supplementary enzyme process of ultrasonic wave draws enterokinase device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205516608U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110074223A (en) * | 2019-04-30 | 2019-08-02 | 福建安溪铁观音集团股份有限公司 | The deep process of a kind of tealeaves leftover bits and pieces and applied to the ultrasonic extractor in the technique |
| CN111111257A (en) * | 2020-01-10 | 2020-05-08 | 楚雄悦丰生物科技有限公司 | Ultrasonic homogenizing device for extracting crude cannabidiol |
| CN113057246A (en) * | 2021-03-26 | 2021-07-02 | 广安万豪生物技术有限公司 | Method for extracting selenoprotein from selenium-enriched edible fungi |
-
2016
- 2016-03-11 CN CN201620186173.1U patent/CN205516608U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110074223A (en) * | 2019-04-30 | 2019-08-02 | 福建安溪铁观音集团股份有限公司 | The deep process of a kind of tealeaves leftover bits and pieces and applied to the ultrasonic extractor in the technique |
| CN111111257A (en) * | 2020-01-10 | 2020-05-08 | 楚雄悦丰生物科技有限公司 | Ultrasonic homogenizing device for extracting crude cannabidiol |
| CN113057246A (en) * | 2021-03-26 | 2021-07-02 | 广安万豪生物技术有限公司 | Method for extracting selenoprotein from selenium-enriched edible fungi |
| CN113057246B (en) * | 2021-03-26 | 2021-12-07 | 广安万豪生物技术有限公司 | Method for extracting selenoprotein from selenium-enriched edible fungi |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160831 |
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| CF01 | Termination of patent right due to non-payment of annual fee |