CN1824095A - Minor network quickening medicinal preparation and its new preparation method - Google Patents
Minor network quickening medicinal preparation and its new preparation method Download PDFInfo
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Abstract
A composite Chinese medicine in the form of dripping pill and soft capsule for treating wind, cold and dampness caused rheumatism, pain of limbs and numbness contracture, and its preparing process are disclosed.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of anemofrigid-damp arthralgia that is used for, limbs pain, the prescription of numbness contracture and preparation technology thereof.
Background technology:
Anemofrigid-damp arthralgia, limbs pain, numbness contracture are clinically to see symptom more, and the traditional Chinese medical science is often taked expelling wind and removing dampness, and the means of active blood stasis dispelling are treated it, and evident in efficacy.XIAOHUOLUO WAN is that it represents medicine.But in the practice, because this medicine is medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, chewable tablet, mixture, its pill that makes can be used for curing mainly anemofrigid-damp arthralgia, limbs pain, numbness contracture.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
90～630 parts of 90～630 parts of Radix Aconiti Kusnezoffii Preparatas of 90～630 parts of Radix Aconiti Preparatas of Arisaema Cum Bile
33～231 parts of 33～231 parts of Myrrha (processed) of 90～630 parts of Olibanums of Pheretima (system)
Preferably:
180 parts of 180 parts of Radix Aconiti Kusnezoffii Preparatas of 180 parts of Radix Aconiti Preparatas of Arisaema Cum Bile
66 parts of 66 parts of Myrrha (processed) of 180 parts of Olibanums of Pheretima (system)
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, capsule, granule, chewable tablet, mixture, medicated wine, fluid extract and extractum, soft extract, plaster.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) get Olibanum, Myrrha two flavor medical materials, adopt supercritical extraction: the medical material of pulverizing is dropped in the supercritical extraction reactor, when pressure reaches 35MPa, 55 ℃ of temperature, CO
2Flow is 15～35kg/h, and constant temperature and pressure extraction 1～5h discharging gets extract:
(2) get Arisaema Cum Bile, Pheretima two flavor medical materials, soaked 30～60 minutes earlier with 50～85% ethanol, reheat reflux, extract, 2～4 times, each 0.5～2 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 2～4 times, each 0.5～2.5 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 5～15 times of amount 60～95% ethanol, left standstill 6～48h, filtered, and the filtrate blood pressure lowering concentrates, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Olibanum, the Myrrha medical material is beaten powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of chewable tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in the preparation of granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, pharmacological research
1.1 experimental technique
Select 50 of male and healthy Wistar rats, raised and train for 1 week under the body weight 180 ± 20g, laboratory condition, be divided into 5 groups at random: blank group, model control group, Glucosidorum Tripterygll Totorum group, technology 1., 2. extractum group.Every group of each 10 rat.Reference literature is seen in modeling method and the volumetrical measurement of the sufficient sole of the foot.
Each is organized dosage and presses human body-rat body surface area ratio and convert as follows: Glucosidorum Tripterygll Totorum group (6.3mg/kg); Technology is 2. extractum group (70mg/kg) of extractum group (30mg/kg), technology 1.; Normal group and model group: wait the capacity normal saline.1h before injection adjuvant, each organizes rat oral gavage 1 time, and measures the different time right back sufficient sole of the foot volume of rat at interval, calculates its swelling degree of the paw (scorching metapedes sole of the foot volume of the scorching front foot sole of the foot volume of swelling degree of the paw=cause-cause; Plan beginning in 8 days behind the Yu Zhiyan, each is organized rat and continues to irritate stomach, every day 1 time, continuous 16 days, and measure the different time left back sufficient sole of the foot volume of rat at interval, calculate its swelling degree of the paw, observe rat claw, ear and afterbody simultaneously and erythema, tuberosity situation occur, put to death whole rats behind the 24th day collect specimen.
1.2 interpretation of result
1.2.1 influence to adjuvant arthritis rats constitutional pathological changes
The 1h administration is 1 time before the Yu Zhiyan, and scorching preceding 1h causes scorching back the 3rd, 6,12,18,24h respectively surveys the right sole of the foot volume of rat 1 time respectively at causing, and calculates its swelling degree of the paw, the results are shown in Table 1.
The influence of table 1 pair AA rat constitutional pedal swelling (x ± SD, n=10)
| Group | The right back swelling degree of the paw of rat (ml) | ||||
| 3h | 6h | 12h | 18h | 24h | |
| Blank group model matched group Tripterygium glycosides blade technolgy is 2. extractum group of extractum group technology 1. | 0.002±0.003 0.60±0.01 * 0.37±0.06 ▲* 0.31±0.05 ▲* 0.36±0.04 ▲* | 0.006±0.005 0.72±0.10 * 0.47±0.07 ▲* 0.39±0.01 ▲* 0.47±0.03 ▲* | 0.01±0.005 0.91±0.12 * 0.58±0.06 ▲* 0.46±0.04 ▲* 0.57±0.03 ▲* | 0.008±0.007 1.07±0.11 * 0.61±0.05 ▲*★ 0.53±0.02 ▲*★ 0.64±0.04 ▲* | 0.010±0.006 1.01±0.13 * 0.52±0.07 ▲*★ 0.39±0.09 ▲*★ 0.51±0.07 ▲* |
Compare with model control group
▲P＜0.05; Compare with the blank group
*P＜0.05; With 2. extractum group comparison of technology
★P＜0.05
As can be seen from Table 1, behind the injection adjuvant, the swelling gradually of the right back sufficient sole of the foot of model group rat in peaking about 18h after the modeling, begins to descend subsequently.Compare with the model group rat, Glucosidorum Tripterygll Totorum group and each extractum group all have the good restraining effect to AA rat constitutional pedal swelling, and wherein 1. extractum group effect is best with Glucosidorum Tripterygll Totorum group and technology.
1.2.2 influence to adjuvant arthritis rats Secondary cases pathological changes
The right back sufficient sole of the foot of model control group rat is swelling and peak in 24h gradually after causing inflammation, continues to begin to disappear after 3 days, and swelling once more after the 8th day peaked in the 15th day, disappeared gradually later on.The hyperemia of swelling local skin, redness, thicken, the skin temperature rise, that touches has a tangible avoidance behaviour, rat creeps because of difficulty, asthenia, movable and feed all reduces, body weight gain slowly and in beginning in the 15th day descends the intensely dark pool of fur to some extent.From the 10th day, left hind, left fore began obvious swelling, mainly showed ankle joint, and involved gradually between whole toe joint and arthroncus appears in the front foot sole of the foot, and erythema and inflammatory brief summary appear in ear and afterbody; The symptom that extractum group rat is occurred is lighter, and the feed situation is better, and body weight continues to increase, and performance is active, the fur Smooth and moist; Though Tripterygium glycosides group rat symptom is lighter, it is less to take food, and weight increase is slow, and asthenia is not liked activity, the coarse or jaundice of fur.Behind the Yu Zhiyan the 8th, 10,12,16,20,24h surveys and respectively organizes the rat paw edema degree, the extractum group obviously is better than each group of blank, model and Glucosidorum Tripterygll Totorum, the results are shown in Table 2.
The influence of table 2 pair AA rat Secondary cases pedal swelling (x ± SD, n=10)
| Group | The left back swelling degree of the paw of rat (ml) | |||||
| 8h | 10h | 12h | 16h | 20h | 24h | |
| Blank group model matched group | 0.06±0.03 0.10±0.04 | 0.07±0.03 0.38±0.13 * | 0.10±0.02 0.65±0.13 * | 0.17±0.04 0.85±0.14 * | 0.19±0.04 0.96±0.17 * | 0.24±0.05 0.89±0.15 * |
| Many glycosides of Thunder God Teng blade technolgy is 2. extractum group of extractum group technology 1. | 0.06±0.03 0.06±0.02 * 0.06±0.03 * | 0.34±0.07 * 0.28±0.11 * 0.29±0.11 * | 0.53±0.12 * 0.57±0.14 * 0.58±0.13 ▲* | 0.52±0.12 ▲* 0.57±0.15 ▲* 0.58±0.16 ▲* | 0.48±0.11 ▲*★ 0.54±0.12 ▲* 0.55±0.14 ▲*★ | 0.43±0.13 ▲*★ 0.49±0.09 ▲* 0.51±0.17 ▲*★ |
Compare with model control group
▲P＜0.05; Compare with the blank group
*P＜0.05; With 1. extractum group comparison of technology
★P＜0.05
As can be seen from Table 2, from injecting back 10h, the swelling gradually of the left back sufficient sole of the foot of model group rat in peaking about 20h after the modeling, begins to descend subsequently.Glucosidorum Tripterygll Totorum group and each extractum group all have the good restraining effect to AA rat Secondary cases pedal swelling, illustrate that the anti-immunization of medicine is effective.
2, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of good treatment anemofrigid-damp arthralgia, limbs pain, the medicine of numbness contracture, and change preparation technology can obviously strengthen its expelling wind and removing dampness, clinical efficacies such as active blood stasis dispelling, its hypotoxicity in addition, therefore prolonged application safety, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Arisaema Cum Bile 180g Radix Aconiti Preparata 180g Radix Aconiti Kusnezoffii Preparata 180g
Pheretima 180g Olibanum (system) 66g Myrrha (processed) 66g
PEG4000 100g
Make 1000 balls
Preparation method:
(1) get Olibanum, Myrrha two flavor medical materials, adopt supercritical extraction: the medical material of pulverizing is dropped in the supercritical extraction reactor, when pressure reaches 35MPa, 55 ℃ of temperature, CO
2Flow is 22kg/h, and constant temperature and pressure extraction 3h discharging gets extract;
(2) get Arisaema Cum Bile, Pheretima two flavor medical materials, soaked 40 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 8 times of amount 95% ethanol, left standstill 12h, filtered, and the filtrate blood pressure lowering concentrates, and is standby;
(4) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Arisaema Cum Bile 306g Radix Aconiti Preparata 306g Radix Aconiti Kusnezoffii Preparata 306g
Pheretima 306g Olibanum (system) 112g Myrrha (processed) 112g
PEG400 350g
Make 1000
Preparation method:
(1) get Olibanum, Myrrha two flavor medical materials, adopt supercritical extraction: the medical material of pulverizing is dropped in the supercritical extraction reactor, when pressure reaches 35MPa, 55 ℃ of temperature, CO
2Flow is 22kg/h, and constant temperature and pressure extraction 3h discharging gets extract;
(2) get Arisaema Cum Bile, Pheretima two flavor medical materials, soaked 40 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 8 times of amount 95% ethanol, left standstill 12h, filtered, and the filtrate blood pressure lowering concentrates, and is standby;
(4) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Arisaema Cum Bile 630g Radix Aconiti Preparata 630g Radix Aconiti Kusnezoffii Preparata 630g
Pheretima 630g Olibanum (system) 231g Myrrha (processed) 231g
Make 1000g
Preparation method:
(1) get Olibanum, the Myrrha medical material is beaten powder and is used as medicine;
(2) get Arisaema Cum Bile, Pheretima two flavor medical materials, soaked 40 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 8 times of amount 95% ethanol, left standstill 12h, filtered, and the filtrate blood pressure lowering concentrates, and is standby;
(4) above active component is merged, add aspartame 5.0g, dextrin 250.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Prescription:
Arisaema Cum Bile 306g Radix Aconiti Preparata 306g Radix Aconiti Kusnezoffii Preparata 306g
Pheretima 306g Olibanum (system) 112g Myrrha (processed) 112g
Make 1000
Preparation method:
(1) get Olibanum, the Myrrha medical material is beaten powder and is used as medicine;
(2) get Arisaema Cum Bile, Pheretima two flavor medical materials, soaked 40 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 8 times of amount 95% ethanol, left standstill 12h, filtered, and the filtrate blood pressure lowering concentrates, and is standby;
(4) above active component is merged, add aspartame 3.0g, mannitol 160.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000 of chewable tablet.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
90～630 parts of 90～630 parts of Radix Aconiti Kusnezoffii Preparatas of 90～630 parts of Radix Aconiti Preparatas of Arisaema Cum Bile
33～231 parts of 33～231 parts of Myrrha (processed) of 90～630 parts of Olibanums of Pheretima (system).
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
180 parts of 180 parts of Radix Aconiti Kusnezoffii Preparatas of 180 parts of Radix Aconiti Preparatas of Arisaema Cum Bile
66 parts of 66 parts of Myrrha (processed) of 180 parts of Olibanums of Pheretima (system).
3, claim 1 or any one Chinese medicine preparation of 2 are drop pill, capsule, granule, chewable tablet, mixture, medicated wine, fluid extract and extractum, soft extract, plaster.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) get Olibanum, Myrrha two flavor medical materials, adopt supercritical extraction: the medical material of pulverizing is dropped in the supercritical extraction reactor, when pressure reaches 35MPa, 55 ℃ of temperature, CO
2Flow is 15～35kg/h, and constant temperature and pressure extraction 1～5h discharging gets extract;
(2) get Arisaema Cum Bile, Pheretima two flavor medical materials, soaked 30～60 minutes earlier with 50～85% ethanol, reheat reflux, extract, 2～4 times, each 0.5～2 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 2～4 times, each 0.5～2.5 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 5～15 times of amount 60～95% ethanol, left standstill 6～48h, filtered, and the filtrate blood pressure lowering concentrates, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Olibanum, the Myrrha medical material is beaten powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) get Olibanum, Myrrha two flavor medical materials, adopt supercritical extraction: the medical material of pulverizing is dropped in the supercritical extraction reactor, when pressure reaches 35MPa, 55 ℃ of temperature, CO
2Flow is 15～35kg/h, and constant temperature and pressure extraction 1～5h discharging gets extract;
(2) get Arisaema Cum Bile, Pheretima two flavor medical materials, soaked 30～60 minutes earlier with 50～85% ethanol, reheat reflux, extract, 2～4 times, each 0.5～2 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 2～4 times, each 0.5～2.5 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 5～15 times of amount 60～95% ethanol, left standstill 6～48h, filtered, and the filtrate blood pressure lowering concentrates, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Olibanum, the Myrrha medical material is beaten powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005101344036A CN1824095A (en) | 2005-12-15 | 2005-12-15 | Minor network quickening medicinal preparation and its new preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005101344036A CN1824095A (en) | 2005-12-15 | 2005-12-15 | Minor network quickening medicinal preparation and its new preparation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394062A (en) * | 2013-08-07 | 2013-11-20 | 司马蕾 | Externally used compound traditional Chinese medicine for treating cancer induced bone pain |
| CN104147278A (en) * | 2014-08-16 | 2014-11-19 | 黑龙江江恒医药科技有限公司 | Xiaohuoluo tablet and preparation method thereof |
| CN105726835A (en) * | 2016-03-30 | 2016-07-06 | 韩志强 | Small collateral circulation activating tablets and preparation method thereof |
| CN107982375A (en) * | 2017-12-04 | 2018-05-04 | 黑龙江参鸽药业有限公司 | A kind of chill is double from the preparation method for turning piece |
-
2005
- 2005-12-15 CN CNA2005101344036A patent/CN1824095A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394062A (en) * | 2013-08-07 | 2013-11-20 | 司马蕾 | Externally used compound traditional Chinese medicine for treating cancer induced bone pain |
| CN103394062B (en) * | 2013-08-07 | 2014-12-17 | 司马蕾 | Externally used compound traditional Chinese medicine for treating cancer induced bone pain |
| CN104147278A (en) * | 2014-08-16 | 2014-11-19 | 黑龙江江恒医药科技有限公司 | Xiaohuoluo tablet and preparation method thereof |
| CN105726835A (en) * | 2016-03-30 | 2016-07-06 | 韩志强 | Small collateral circulation activating tablets and preparation method thereof |
| CN107982375A (en) * | 2017-12-04 | 2018-05-04 | 黑龙江参鸽药业有限公司 | A kind of chill is double from the preparation method for turning piece |
| CN107982375B (en) * | 2017-12-04 | 2021-07-16 | 黑龙江参鸽药业有限公司 | Preparation method of wind-cold double-throw piece |
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