CN1824117A - Menstruation regulating blood nourishing medicinal preparation and its new preparation method - Google Patents
Menstruation regulating blood nourishing medicinal preparation and its new preparation method Download PDFInfo
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Abstract
A composite Chinese medicine in the form of dripping pill and soft capsule for treating blood deficiency, qi stagnation, menoxenia, lumbar ache, abdominalgia, and its preparing process are disclosed.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of blood deficiency stagnation of QI that is used for, menoxenia, the prescription and the preparation technology thereof of soreness of waist stomachache.
Background technology:
The blood deficiency stagnation of QI, menoxenia, soreness of waist stomachache is clinically to see that symptom, the traditional Chinese medical science often take to regulate the flow of vital energy more, nourishes blood, the means of stimulating the menstrual flow are treated it, and evident in efficacy.The menstruation regulating blood nourishing medicinal ball is that it represents medicine.But in the practice, because this medicine is medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, chewable tablet, its pill that makes can be used for curing mainly the blood deficiency stagnation of QI, menoxenia, soreness of waist stomachache.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
124～354 parts of 41～118 portions of Rhizoma Cyperis of 21～59 parts of Rhizoma Atractylodis Macrocephalaes of Radix Angelicae Sinensis (processed with wine) (parching with earth) (system)
41～118 parts of 124～354 parts of Radix Aucklandiae of 10～29.6 parts of Herba Leonuris of Radix Rehmanniae Preparata (processed with wine)
31～88 parts of 10～29.6 parts of Spatholobi Pastes of 15.5～44 parts of Radix Salviae Miltiorrhizaes of Radix Dipsaci are preferred:
177 parts of 59 portions of Rhizoma Cyperis of 29.5 parts of Rhizoma Atractylodis Macrocephalaes of Radix Angelicae Sinensis (processed with wine) (parching with earth) (system)
59 parts of 177 parts of Radix Aucklandiae of 14.8 parts of Herba Leonuris of Radix Rehmanniae Preparata (processed with wine)
44.2 parts of 14.8 parts of Spatholobi Pastes of 22.1 parts of Radix Salviae Miltiorrhizaes of Radix Dipsaci
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, capsule, granule, tablet, mixture, fluid extract and extractum, soft extract, powder.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) gets Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Cyperi, the about material of the Radix Aucklandiae four flavors, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate; Gained water extract filters, and is condensed into thick extractum, and is standby; Water extract device in addition stores, and leaves standstill, and filters, and filtrate concentrates, and is standby;
(2) get Herba Leonuri, Caulis Spatholobi medical material, decoct with water 2～5 times, each 0.5～6 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(3) get the residue medical material, soaked 30～60 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～5 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting Radix Rehmanniae Preparata, Radix Dipsaci, red rooted salvia beats powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and capsule.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of chewable tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in the preparation of granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, to the blood tonification effect of normal mouse
Get body weight and be 40 of the female Kunming mouses of 20～25g, be divided at random distilled water group, WUJI BAIFENG WAN group (2.85g crude drug/kg), technology 1., 2. extractum group.Continuous ig administration 12d.40min behind the last medicine, eye socket get blood and survey RBC, Hb, the results are shown in Table 1.
The influence of table 1 pair normal mouse hemogram (n=10, x ± s)
| Group | Dosage (g/kg) | RBC(10 12/L) | Hb(g/L) |
| Distilled water group BAIFENGWAN group technology is 2. extractum group of extractum group technology 1. | - 2.85 0.46 0.62 | 7.1326±0.6157 7.5513±0.7254 * 8.1928±0.3054 * 7.7212±0.3186 * | 122.01±8.79 121.87±10.14 131.82±5.63 * 127.95±5.71 * |
Annotate: compare with the distilled water group,
*P＜0.05
By table 1 as seen, extractum group RBC, Hb obviously increase, and have significant difference between the distilled water group.
2, analgesic activity (writhing method)
Get 40 of body weight 18～22g mices, press the ig of grouping shown in the table 2 administration, continuously 4d.30min behind the last medicine, every Mus lumbar injection 0.7% glacial acetic acid solution 0.5ml.Observe producing the writhing response number of times in each Mus writhing response time started (incubation period) and 10min and the 20min, the results are shown in Table 2.
Table 2 pair writhing method analgesic activity (n=10, x ± s)
| Group | Dosage (g/kg) | Incubation period (s) | Turn round body number (inferior) | |
| 10min | 20min | |||
| The white wind ball of distilled water group group technology is 2. medicinal extract group of medicinal extract group technology 1. | - 2.85 0.46 0.62 | 2.49±1.13 4.41±1.25 ** 6.62±1.28 ** 5.37±1.34 ** | 22.68±4.31 9.76±3.62 ** (56.97) 3.89±2.14 ** (82.85) 6.54±2.35 ** (71.16) | 40.29±7.84 26.31±6.19 ** (34.70) 14.63±7.78 ** (63.69) 17.29±7.16 ** (57.09) |
Annotate: compare with the distilled water group,
*P＜0.01
By table 2 as seen, each administration group mice causes pain and obviously prolongs incubation period, and the writhing response number of times obviously reduces in 10min, the 20min, relatively has significant difference with the distilled water group.
3, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of good treatment blood deficiency stagnation of QIs, menoxenia, the medicine of soreness of waist stomachache, and change preparation technology, can obviously strengthen it and regulate the flow of vital energy, nourish blood, clinical efficacy such as stimulate the menstrual flow, its hypotoxicity in addition, prolonged application safety, therefore, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Radix Angelicae Sinensis (processed with wine) the 21g Rhizoma Atractylodis Macrocephalae (parching with earth) 41g Rhizoma Cyperi (system) 124g
Radix Rehmanniae Preparata (processed with wine) 10g Herba Leonuri 124g Radix Aucklandiae 41g
Radix Dipsaci 15.5g Radix Salviae Miltiorrhizae 10g Spatholobi Paste 31g
PEG4000 100g
Make 1000 balls
Preparation method:
(1) gets Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Cyperi, Radix Aucklandiae four Chinese medicine material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 6 with β-CD ratio, and ultrasonic 40min gets clathrate; Gained water extract filters, and is condensed into thick extractum, and is standby; Water extract device in addition stores, and leaves standstill, and filters, and filtrate concentrates, and is standby;
(2) get Herba Leonuri, Caulis Spatholobi medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(3) get the residue medical material, soaked 30 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(4) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Radix Angelicae Sinensis (processed with wine) the 77g Rhizoma Atractylodis Macrocephalae (parching with earth) 153.4g Rhizoma Cyperi (system) 460g
Radix Rehmanniae Preparata (processed with wine) 38.5g Herba Leonuri 460g Radix Aucklandiae 153.4g
Radix Dipsaci 57.5g Radix Salviae Miltiorrhizae 38.5g Spatholobi Paste 115g
PEG400 430g
Make 1000
Preparation method:
(1) gets Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Cyperi, Radix Aucklandiae four Chinese medicine material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 6 with β-CD ratio, and ultrasonic 40min gets clathrate; Gained water extract filters, and is condensed into thick extractum, and is standby; Water extract device in addition stores, and leaves standstill, and filters, and filtrate concentrates, and is standby;
(2) get Herba Leonuri, Caulis Spatholobi medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(3) get the residue medical material, soaked 30 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(4) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Radix Angelicae Sinensis (processed with wine) the 118g Rhizoma Atractylodis Macrocephalae (parching with earth) 59g Rhizoma Cyperi (system) 708g
Radix Rehmanniae Preparata (processed with wine) 59g Herba Leonuri 708g Radix Aucklandiae 236g
Radix Dipsaci 88g Radix Salviae Miltiorrhizae 236g Spatholobi Paste 177g
Make 1000g
Preparation method:
(1) gets Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Cyperi, Radix Aucklandiae four Chinese medicine material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 6 with β-CD ratio, and ultrasonic 40min gets clathrate; Gained water extract filters, and is condensed into thick extractum, and is standby; Water extract device in addition stores, and leaves standstill, and filters, and filtrate concentrates, and is standby;
(2) get Herba Leonuri, Caulis Spatholobi medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(3) getting the residue medical material beats powder and is used as medicine;
(4) above active component is merged, add aspartame 5.0g, dextrin 250.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Prescription:
Radix Angelicae Sinensis (processed with wine) the 77g Rhizoma Atractylodis Macrocephalae (parching with earth) 153.4g Rhizoma Cyperi (system) 460g
Radix Rehmanniae Preparata (processed with wine) 38.5g Herba Leonuri 460g Radix Aucklandiae 153.4g
Radix Dipsaci 57.5g Radix Salviae Miltiorrhizae 38.5g Spatholobi Paste 115g
Make 1000
Preparation method:
(1) gets Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Cyperi, Radix Aucklandiae four Chinese medicine material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 6 with β-CD ratio, and ultrasonic 40min gets clathrate; Gained water extract filters, and is condensed into thick extractum, and is standby; Water extract device in addition stores, and leaves standstill, and filters, and filtrate concentrates, and is standby;
(2) get Herba Leonuri, Caulis Spatholobi medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(3) getting the residue medical material beats powder and is used as medicine;
(4) above active component is merged, add aspartame 3.0g, mannitol 200.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000 of chewable tablet.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
124～354 parts of 41～118 portions of Rhizoma Cyperis of 21～59 parts of Rhizoma Atractylodis Macrocephalaes of Radix Angelicae Sinensis (processed with wine) (parching with earth) (system)
41～118 parts of 124～354 parts of Radix Aucklandiae of 10～29.6 parts of Herba Leonuris of Radix Rehmanniae Preparata (processed with wine)
31～88 parts of 10～29.6 parts of Spatholobi Pastes of 15.5～44 parts of Radix Salviae Miltiorrhizaes of Radix Dipsaci.
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
177 parts of 59 portions of Rhizoma Cyperis of 29.5 parts of Rhizoma Atractylodis Macrocephalaes of Radix Angelicae Sinensis (processed with wine) (parching with earth) (system)
59 parts of 177 parts of Radix Aucklandiae of 14.8 parts of Herba Leonuris of Radix Rehmanniae Preparata (processed with wine)
44.2 parts of 14.8 parts of Spatholobi Pastes of 22.1 parts of Radix Salviae Miltiorrhizaes of Radix Dipsaci.
3, claim 1 or any one Chinese medicine preparation of 2 are drop pill, capsule, granule, tablet, mixture, fluid extract and extractum, soft extract, powder.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) gets Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Cyperi, Radix Aucklandiae four Chinese medicine material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate; Gained water extract filters, and is condensed into thick extractum, and is standby; Water extract device in addition stores, and leaves standstill, and filters, and filtrate concentrates, and is standby;
(2) get Herba Leonuri, Caulis Spatholobi medical material, decoct with water 2～5 times, each 0.5～6 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(3) get the residue medical material, soaked 30～60 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～5 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting Radix Rehmanniae Preparata, Radix Dipsaci, red rooted salvia beats powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and capsule.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) gets Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Cyperi, Radix Aucklandiae four Chinese medicine material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate; Gained water extract filters, and is condensed into thick extractum, and is standby; Water extract device in addition stores, and leaves standstill, and filters, and filtrate concentrates, and is standby;
(2) get Herba Leonuri, Caulis Spatholobi medical material, decoct with water 2～5 times, each 0.5～6 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(3) get the residue medical material, soaked 30～60 minutes earlier with 50～95% ethanol, the reheat cocurrent flow extracts 2～5 times, and each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting Radix Rehmanniae Preparata, Radix Dipsaci, red rooted salvia beats powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and capsule.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610000746 CN1824117A (en) | 2006-01-12 | 2006-01-12 | Menstruation regulating blood nourishing medicinal preparation and its new preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610000746 CN1824117A (en) | 2006-01-12 | 2006-01-12 | Menstruation regulating blood nourishing medicinal preparation and its new preparation method |
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| Publication Number | Publication Date |
|---|---|
| CN1824117A true CN1824117A (en) | 2006-08-30 |
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| CN 200610000746 Pending CN1824117A (en) | 2006-01-12 | 2006-01-12 | Menstruation regulating blood nourishing medicinal preparation and its new preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110721268A (en) * | 2019-11-28 | 2020-01-24 | 楼基祥 | Traditional Chinese medicine preparation for treating gynecological infertility |
| CN113491752A (en) * | 2021-08-31 | 2021-10-12 | 西安市灞桥区浐灞御锦城社区卫生服务站 | Traditional Chinese medicine preparation for treating gynecological diseases in cooperation with acupuncture |
-
2006
- 2006-01-12 CN CN 200610000746 patent/CN1824117A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110721268A (en) * | 2019-11-28 | 2020-01-24 | 楼基祥 | Traditional Chinese medicine preparation for treating gynecological infertility |
| CN113491752A (en) * | 2021-08-31 | 2021-10-12 | 西安市灞桥区浐灞御锦城社区卫生服务站 | Traditional Chinese medicine preparation for treating gynecological diseases in cooperation with acupuncture |
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