CN1548065A - Compound Chinese medicine for treating chronic pulvic infection and prepn process of its prepn forms - Google Patents
Compound Chinese medicine for treating chronic pulvic infection and prepn process of its prepn forms Download PDFInfo
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Abstract
The complex Chinese medicine for treating chronic pulvic infection is prepared with honeysuckle, red peony root, skullcap root, forsythia, peony bark and other nine kinds of Chinese medicinal materials in certain proportion. It is prepared into granule, capsule, tablet, oral liquid and other preparation forms. It has obvious determined treating effect on chronic pulvic infection with the pathologic changes of inflammation effusion, tissue proliferation, adhesion, etc.
Description
Technical field: the preparation method that the present invention relates to a kind of traditional Chinese compound medicine and several dosage forms thereof.
Background technology: chronic pelvic inflammatory disease belongs to common clinical, account for 30～40% of gynaecopathia, and from clinical practice, can account for the outpatient's of gynecological about 50%, simultaneously, chronic pelvic inflammatory disease is again a difficult disease, touching difficulty more, outbreak repeatedly, the course of treatment length, weak curative effect, medical expense height, become the brainstorm subject that domestic and international medical worker attractes attention.At present, doctor trained in Western medicine still can't obtain desirable curative effect, and is particularly poorer to pelvic tissue adhesion and perilesional connective tissue parcel severe patient curative effect.The Chinese medicine of this disease of treatment mainly is enema and suppository at present, if but the subjective symptoms of these drug main reduction of patient is not good to patient's local sign and focus pathological change improvement.
Summary of the invention: the object of the present invention is to provide a kind of traditional Chinese compound medicine of chronic pelvic inflammatory disease and preparation method of several dosage forms thereof for the treatment of safely and effectively, the traditional Chinese compound medicine of treatment chronic pelvic inflammatory disease comprises following composition: Flos Lonicerae, Radix Paeoniae Rubra, Radix Scutellariae, Fructus Forsythiae, Cortex Moutan, Semen Persicae, Rhizoma Curcumae, Rhizoma Cyperi, Rhizoma Corydalis, Sargassum, Concha Ostreae, Semen Coicis, Spina Gleditsiae, Radix Bupleuri, the gram number of each composition is: Flos Lonicerae 130～170g, Radix Paeoniae Rubra 70～110g, Radix Scutellariae 60～90g, Fructus Forsythiae 60～90g, Cortex Moutan 45～75g, Semen Persicae 20～45g, Rhizoma Curcumae 60～90g, Rhizoma Cyperi 45～75g, Rhizoma Corydalis 45～75g, Sargassum 60～90g, Concha Ostreae 35～70g, Semen Coicis 60～90g, Spina Gleditsiae 45～75g, Radix Bupleuri 45～75g.The preparation method of the traditional Chinese compound medicine granule of treatment chronic pelvic inflammatory disease is: a. is with Fructus Forsythiae 60～90g, Cortex Moutan 45～75g, Rhizoma Curcumae 60～90g, Rhizoma Cyperi 45～75g, Radix Bupleuri 45～75g decocts with water after mixing, extract volatile oil, aqueous solution after distillation device is in addition collected, with the surplus medicinal residues of institute and Flos Lonicerae 130～170g, Radix Paeoniae Rubra 70～110g, Radix Scutellariae 60～90g, Semen Persicae 20～45g, Rhizoma Corydalis 45～75g, Sargassum 60～90g, Concha Ostreae 35～70g, Semen Coicis 60～90g, Spina Gleditsiae 45～75g decocts with water twice after mixing, each 1～3 hour, collecting decoction, filter, then with filtrate and Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, aqueous solution after the Radix Bupleuri distillation merges, be concentrated into relative density and be 1.38～1.40 extractum, spray-dried dry extract; B. with the volatile oil cyclodextrin inclusion compound of aforementioned Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, Radix Bupleuri, spray-driedly must do the enclose powder; C. with aforesaid dry extract and dried enclose powder mix homogeneously, add an amount of sucrose as adjuvant, mixing is drying to obtain granule.Capsular preparation method is: a. is with Fructus Forsythiae 60～90g, Cortex Moutan 45～75g, Rhizoma Curcumae 60～90g, Rhizoma Cyperi 45～75g, Radix Bupleuri 45～75g decocts with water after mixing, extract volatile oil, aqueous solution after distillation device is in addition collected, with the surplus medicinal residues of institute and Flos Lonicerae 130～170g, Radix Paeoniae Rubra 70～110, Radix Scutellariae 60～90g, Semen Persicae 20～45g, Rhizoma Corydalis 45～75g, Sargassum 60～90g, Concha Ostreae 35～70g, Semen Coicis 60～90g, Spina Gleditsiae 45～75g decocts with water twice after mixing, each 1～3 hour, collecting decoction, filter, then with filtrate and Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, aqueous solution after the Radix Bupleuri distillation merges, be concentrated into relative density and be 1.38～1.40 extractum, spray-dried dry extract; B. with the volatile oil cyclodextrin inclusion compound of aforementioned Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, Radix Bupleuri, spray-driedly must do the enclose powder; C. with aforesaid dry extract and dried enclose powder mix homogeneously, add appropriate amount of starch as adjuvant, mixing incapsulates promptly.The preparation method of tablet is: a. is with Fructus Forsythiae 60～90g, Cortex Moutan 45～75g, Rhizoma Curcumae 60～90g, Rhizoma Cyperi 45～75g, Radix Bupleuri 45～75g decocts with water after mixing, extract volatile oil, aqueous solution after distillation device is in addition collected, with the surplus medicinal residues of institute and Flos Lonicerae 130～170g, Radix Paeoniae Rubra 70～110g, Radix Scutellariae 60～90g, Semen Persicae 20～45g, Rhizoma Corydalis 45～75g, Sargassum 60～90g, Concha Ostreae 35～70g, Semen Coicis 60～90g, Spina Gleditsiae 45～75g decocts with water twice after mixing, each 1～3 hour, collecting decoction, filter, then with filtrate and Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, aqueous solution after the Radix Bupleuri distillation merges, be concentrated into relative density and be 1.38～1.40 extractum, spray-dried dry extract; B. with the volatile oil cyclodextrin inclusion compound of aforementioned Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, Radix Bupleuri, spray-driedly must do the enclose powder; C. with aforesaid dry extract and dried enclose powder mix homogeneously, add an amount of carboxymethyl starch sodium and starch and do adjuvant, mixing is made behind the granule repress and is made sheet and get final product.The preparation method of oral liquid is: a. is with Fructus Forsythiae 60～90g, Cortex Moutan 45～75g, Rhizoma Curcumae 60～90g, Rhizoma Cyperi 45～75g, Radix Bupleuri 45～75g decocts with water after mixing, extract volatile oil, aqueous solution after distillation device is in addition collected, with the surplus medicinal residues of institute and Flos Lonicerae 130～170g, Radix Paeoniae Rubra 70～110g, Radix Scutellariae 60～90g, Semen Persicae 20～45g, Rhizoma Corydalis 45～75g, Sargassum 60～90g, Concha Ostreae 35～70g, Semen Coicis 60～90g, Spina Gleditsiae 45～75g decocts with water twice after mixing, each 1～3 hour, collecting decoction, filter, then with filtrate and Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, aqueous solution after the Radix Bupleuri distillation merges, and is concentrated into relative density and is 1.38～1.40 extractum; B. adding the concentration account for 4～6 times of extractum volumes and be 50～80% ethanol in aforementioned extractum stirs, after static 20～26 hours, get supernatant filter, centrifugal, to be evaporated to proportion be 1.10～1.30 extractum, thin up to 500～800ml, cold preservation is 20～26 hours then, filters, and filtrate adds the volatile oil of aforementioned Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, Radix Bupleuri and an amount of antiseptic, add an amount of water, stir evenly filtration promptly.Simple, the operation easily of the preparation method of the traditional Chinese compound medicine granule of treatment chronic pelvic inflammatory disease of the present invention, capsule, tablet, oral liquid, medicine of the present invention has heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, the effect of softening the hard mass dehumidifying can be treated chronic pelvic inflammatory disease effectively.Flos Lonicerae in the side, sweet, cold, heat-clearing and toxic substances removing is the key medicine of treatment damp-heat disease, outer infections abscess of internal organ.Modern pharmacological research shows: this medical instrument has broad-spectrum antibacterial action, and various bacteria, leptospira, virus are all had inhibitory action in various degree.Have antiinflammatory action simultaneously, both suppressed inflammatory exudation, suppress inflammatory hyperplasia again, and can be analgesic and promote leukocytic phagocytic function.Radix Paeoniae Rubra, but bitter, be slightly cold, the merit clearing away heat and cooling blood, stasis-dispelling and pain-killing.Shennong's Herbal is said: " arthralgia due to stagnation of blood falls in main pathogen stomachache, and is broken hard long-pending, cold and heat hernia abdominal mass, pain relieving ... ".Modern pharmacological research proves: this product has broad-spectrum antibacterial action, and effects such as spasmolytic, calmness, pain relieving are arranged.Primary disease no matter demonstrate,prove by damp and hot stasis of blood knot, or syndrome of qi stagnation and blood stasis all has the existence of blood stasis, and the clearing away heat and cooling blood function of Radix Paeoniae Rubra can strengthen monarch drug heat extraction effect, and the function of its stasis-dispelling and pain-killing can cooperate monarch drug treatment accompanied symptoms, so also think minister.Primary disease state of an illness more complicated, accompanied symptoms is more, so suitable numerous adjuvant drugs are to strengthen the effect of monarch, all medicines of minister.Fructus Forsythiae, little suffering, hardship, cold, function is a heat-clearing and toxic substances removing, mass dissipating and swelling eliminating." Records of Tradition Chinese and Western Medicine in Combination " said: " the Fructus Forsythiae tool rises the diffusing power of floating a surname, and the circulation QI and blood is controlled 12 and gathered through blood clotting gas ... and the performance eliminating the toxic material out by tonification ".Li Gao says: " all menses stagnation of QI that looses are poly-, detumescence ".Modern pharmacological research shows: this product tool broad-spectrum antibacterial action also has the anti-mycobacterium tuberculosis effect, as stronger with effect together with Radix Scutellariae.Obvious inhibition inflammatory exudation is arranged simultaneously, strengthen the phagocytic activity of emigrated cell, analgesic, town's Tuhe diuresis is still arranged.Can strengthen the efficacy of a drug of monarch-minister drug, so think assistant.Cortex Moutan, is slightly cold at toil, but the merit clearing away heat and cooling blood, the diffusing block up of invigorating blood circulation.Shennong's Herbal is said: " heat clearing away and restlessness relieving, benefaction stasis ... promoting the circulation of blood is stagnant and not high ".Modern pharmacological research proves: this product can suppress capillary permeability and the effect that has clear and definite anti-inflammatory to ooze out, and central analgesia, calmness, convulsion, refrigeration function are arranged simultaneously.And a plurality of strains there is stronger antibacterial action.Semen Persicae, bitter, flat, merit tool blood circulation promoting and blood stasis dispelling." herbal classic " said: " go that the stasis of blood, blood close, little abdominal mass, pathogen, kill small worm ".Modern pharmacological research proves: this product expands blood vessel, increases blood flow, improves CAMP level in the platelet, and the inhibition blood flow solidifies, the impervious blood effect of inflammation initial stage is strong.It is assistant with the power that increases promoting blood flow and remove blood stasis that Cortex Moutan, Semen Persicae help Radix Paeoniae Rubra.Rhizoma Curcumae, arduous, warm, merit tool removing blood stasis, promoting the circulation of QI to relieve pain." Bencao Jingshu " said: " Rhizoma Curcumae circulation of qi promoting removing blood stasis eliminating stagnation is the chief of its function ".Modern pharmacology proves: this product has antibiotic and anti-granulation tissue hyperplasia effect.Promote the intraperitoneal autoblood to absorb, the zoopery cancer is had suppress and destruction.Rhizoma Cyperi, little hardship is sweet, flat, its merit depressed liver-energy dispersing and QI regulating, menstruction regulating and pain relieving.Compendium of Material Medica is said: " sharp three warmers are separated six kinds of stagnation-syndromes, and the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot abdominal distention ... " modern pharmacological research prove: this product has antiinflammatory, analgesia and certain refrigeration function, and maincenter is had stable effect, and suppresses uterine contraction.Rhizoma Corydalis, arduous, warm, the merit tool diffusing block up of invigorating blood circulation, promoting the circulation of QI to relieve pain." Kaibao Bencao " said: " main removing blood stasis ... married woman's menoxenia lumps in the abdomen "." book on Chinese herbal medicine is looked for the truth " said: " no matter be that blood is gas, amass and the person that do not loose, obey this power can lead to ... so manage the whole body all pains up and down ".Modern pharmacological research proves: this product has central pain relieving, calm and stable effect.Rhizoma Curcumae, Rhizoma Cyperi, the pain relieving of Rhizoma Corydalis promoting flow of QI and blood, the treatment qi depression to blood stasis accompanied symptoms, so with the adjuvant drug name it.Concha Ostreae, salty, be slightly cold, suppressing the hyperactive liver and subsiding YANG, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating.Compendium of Material Medica is said: " resolving phlegm and softening hard masses, removing damp-heat ... little abdominal mass that disappears is amassed piece, wart disease tuberculosis ".Sargassum, salty, cold, softening the hard mass expectorant, inducing diuresis to remove edema." herbal classic " said: " broken eliminating stagnation gas, carbuncle, the hard gas of note of the ancient Chinese abdominal mass, ring up and down in the abdomen, end opening edema ".Modern pharmacological research shows: can promote the absorption of pathologic product such as inflammation exudate, and make diseased tissue collapse and dissolving.Concha Ostreae, Sargassum, softening and eliminating sputum eliminating stagnation be with the removing food stagnancy piece, strengthens the curative effect of all medicines of the monarch and his subjects and be assistant.Semen Coicis, sweet light, be slightly cold, but the spleen invigorating of merit dampness removing, clearing away heat and discharging pus." herbal classic " said: " with Semen Coicis, dehumidifying and not as two arts help dry, heat clearing away and connect the generation and decrease the moon not as a kind of reed mentioned in ancient books, QI invigorating and still grow damp and hot not as ginseng art generation ".Modern pharmacological research proves: this product has calmness, analgesia and refrigeration function, and antitumaous effect is arranged in zoopery.Its promoting diuresis and pus discharge is with take-up, and assistant the monarch and his subjects' medicine is with clear curative effect.Radix Bupleuri, toil, cold, but merit reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang.Shennong's Herbal is said: " stagnation of QI in main trusted subordinate, the intestines and stomach, diet gathers, the cold and heat pathogen pushes away Chen Zhixin ".Modern pharmacological research proves: " that this product has is analgesic, calm, analgesia and anti-inflammatory ooze out, suppress the granuloma hypertrophy, reduce multiple effect such as vascular permeability.Spina Gleditsiae, Xin Wen, function expelling pus and toxin by strengthening QI, promoting blood circulation and detumescence." book on Chinese herbal medicine receive order " said: " its sharp keen through sick institute ".CHONG meridian being the blood pool, the liver department sea of blood; Blood chamber (uterus) belongs to half exterior and half interior, also is sent in liver.Modern Radix Bupleuri, Spina Gleditsiae dispersing the stagnated live-QI to relieve the stagnation of QI and blood detumescence, through sick institute and for making." this shows: we are monarch with the Flos Lonicerae; Radix Paeoniae Rubra, Radix Scutellariae are minister; Fructus Forsythiae, Cortex Moutan, Semen Persicae, Rhizoma Curcumae, Rhizoma Cyperi, Rhizoma Corydalis, Sargassum, Concha Ostreae, all medicines of Semen Coicis are assistant; Radix Bupleuri, the through disease of Spina Gleditsiae are done and are made.Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae in the side, heat-clearing and toxic substances removing dampness; Radix Paeoniae Rubra, Cortex Moutan, Semen Persicae blood circulation promoting and blood stasis dispelling; Rhizoma Curcumae, Rhizoma Cyperi, the pain relieving of Rhizoma Corydalis promoting flow of QI and blood; Sargassum, Concha Ostreae softening and eliminating sputum eliminating stagnation are with the removing food stagnancy piece; The Semen Coicis promoting diuresis to eliminate damp pathogen is to remove leukorrhagia; The through the lower-JIAO syndrome institute of all medicines is drawn in Radix Bupleuri, Spina Gleditsiae soothing liver-QI for relieving depression and blood detumescence.There is the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, softening the hard mass dehumidifying comprehensive full side.From the achievement in research of modern pharmacology about all medicines of we, the inflammatory exudation that we cause chronic pelvic inflammatory disease really, the hypertrophy of tissue, pathological changes such as adhesion have clear and definite therapeutical effect.Simultaneously we's pharmacodynamic experiment result and the observation of clinical case had for many years been confirmed definite curative effect to chronic pelvic inflammatory disease already.
The specific embodiment one: the traditional Chinese compound medicine of treatment chronic pelvic inflammatory disease comprises following composition in the present embodiment: Flos Lonicerae, Radix Paeoniae Rubra, Radix Scutellariae, Fructus Forsythiae, Cortex Moutan, Semen Persicae, Rhizoma Curcumae, Rhizoma Cyperi, Rhizoma Corydalis, Sargassum, Concha Ostreae, Semen Coicis, Spina Gleditsiae, Radix Bupleuri, the gram number of each composition is: Flos Lonicerae 130～170g, Radix Paeoniae Rubra 70～110g, Radix Scutellariae 60～90g, Fructus Forsythiae 60～90g, Cortex Moutan 45～75g, Semen Persicae 20～45g, Rhizoma Curcumae 60～90g, Rhizoma Cyperi 45～75g, Rhizoma Corydalis 45～75g, Sargassum 60～90g, Concha Ostreae 35～70g, Semen Coicis 60～90g, Spina Gleditsiae 45～75g, Radix Bupleuri 45～75g, the gram of each composition count the best and are: Flos Lonicerae 150g, Radix Paeoniae Rubra 90g, Radix Scutellariae 75g, Fructus Forsythiae 75g, Cortex Moutan 60g, Semen Persicae 35g, Rhizoma Curcumae 75g, Rhizoma Cyperi 60g, Rhizoma Corydalis 60g, Sargassum 75g, Concha Ostreae 50g, Semen Coicis 75g, Spina Gleditsiae 60g, Radix Bupleuri 60g.
The specific embodiment two: the traditional Chinese compound medicine of present embodiment treatment chronic pelvic inflammatory disease is characterized in that the gram number of each composition is: Flos Lonicerae 135～145g, Radix Paeoniae Rubra 75～85g, Radix Scutellariae 65～75g, Fructus Forsythiae 65～75g, Cortex Moutan 50～55g, Semen Persicae 25～30g, Rhizoma Curcumae 65～70g, Rhizoma Cyperi 50～60g, Rhizoma Corydalis 50～55g, Sargassum 65～70g, Concha Ostreae 40～50g, Semen Coicis 65～70g, Spina Gleditsiae 50～55g, Radix Bupleuri 50～55g.
The specific embodiment three: the traditional Chinese compound medicine of present embodiment treatment chronic pelvic inflammatory disease is characterized in that the gram number of each composition is: Flos Lonicerae 150～155g, Radix Paeoniae Rubra 90～95g, Radix Scutellariae 80～85g, Fructus Forsythiae 80～85g, Cortex Moutan 60～65g, Semen Persicae 35～40g, Rhizoma Curcumae 75～80g, Rhizoma Cyperi 65～70g, Rhizoma Corydalis 60～70g, Sargassum 75～80g, Concha Ostreae 55～60g, Semen Coicis 75～80g, Spina Gleditsiae 60～65g, Radix Bupleuri 60～65g.
The specific embodiment four: the traditional Chinese compound medicine of present embodiment treatment chronic pelvic inflammatory disease is characterized in that the gram number of each composition is: Flos Lonicerae 160～165g, Radix Paeoniae Rubra 100～105g, Radix Scutellariae 86～89g, Fructus Forsythiae 86～89g, Cortex Moutan 66～74g, Semen Persicae 41～44g, Rhizoma Curcumae 81～89g, Rhizoma Cyperi 71～74g, Rhizoma Corydalis 71～74g, Sargassum 81～89g, Concha Ostreae 61～69g, Semen Coicis 81～89g, Spina Gleditsiae 70～74g, Radix Bupleuri 70～74g.
The specific embodiment five: the preparation method of the traditional Chinese compound medicine granule of present embodiment treatment chronic pelvic inflammatory disease is: a. is with Fructus Forsythiae 60～90g, Cortex Moutan 45～75g, Rhizoma Curcumae 60～90g, Rhizoma Cyperi 45～75g, Radix Bupleuri 45～75g decocts with water after mixing, extract volatile oil, aqueous solution after distillation device is in addition collected, with the surplus medicinal residues of institute and Flos Lonicerae Flos Lonicerae 130～170g, Radix Paeoniae Rubra 70～110g, Radix Scutellariae 60～90g, Semen Persicae 20～45g, Rhizoma Corydalis 45～75g, Sargassum 60～90g, Concha Ostreae 35～70g, Semen Coicis 60～90g, Spina Gleditsiae 45～75g decocts with water twice after mixing, each 1～3 hour, collecting decoction, filter, then with filtrate and Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, aqueous solution after the Radix Bupleuri distillation merges, be concentrated into relative density and be 1.38～1.40 extractum, spray-dried dry extract; B. with the volatile oil cyclodextrin inclusion compound of aforementioned Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, Radix Bupleuri, spray-driedly must do the enclose powder; C. with aforesaid dry extract and dried enclose powder mix homogeneously, add an amount of sucrose as adjuvant, mixing is drying to obtain granule.
The specific embodiment six: the capsular preparation method of traditional Chinese compound medicine of present embodiment treatment chronic pelvic inflammatory disease is: a. is with Fructus Forsythiae 60～90g, Cortex Moutan 45～75g, Rhizoma Curcumae 60～90g, Rhizoma Cyperi 45～75g, Radix Bupleuri 45～75g decocts with water after mixing, extract volatile oil, aqueous solution after distillation device is in addition collected, with the surplus medicinal residues of institute and Flos Lonicerae 130～170g, Radix Paeoniae Rubra 70～110g, Radix Scutellariae 60～90g, Semen Persicae 20～45g, Rhizoma Corydalis 45～75g, Sargassum 60～90g, Concha Ostreae 35～70g, Semen Coicis 60～90g, Spina Gleditsiae 45～75g decocts with water twice after mixing, each 1～3 hour, collecting decoction, filter, then with filtrate and Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, aqueous solution after the Radix Bupleuri distillation merges, be concentrated into relative density and be 1.38～1.40 extractum, spray-dried dry extract; B. with the volatile oil cyclodextrin inclusion compound of aforementioned Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, Radix Bupleuri, spray-driedly must do the enclose powder; C. with aforesaid dry extract and dried enclose powder mix homogeneously, add appropriate amount of starch as adjuvant, mixing incapsulates promptly.
The specific embodiment seven: the preparation method of the traditional Chinese compound medicine tablet of present embodiment treatment chronic pelvic inflammatory disease is: a. is with Fructus Forsythiae 60～90g, Cortex Moutan 45～75g, Rhizoma Curcumae 60～90g, Rhizoma Cyperi 45～75g, Radix Bupleuri 45～75g decocts with water after mixing, extract volatile oil, aqueous solution after distillation device is in addition collected, with the surplus medicinal residues of institute and Flos Lonicerae 130～170g, Radix Paeoniae Rubra 70～110g, Radix Scutellariae 60～90g, Semen Persicae 20～45g, Rhizoma Corydalis 45～75g, Sargassum 60～90g, Concha Ostreae 35～70g, Semen Coicis 60～90g, Spina Gleditsiae 45～75g decocts with water twice after mixing, each 1～3 hour, collecting decoction, filter, then with filtrate and Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, aqueous solution after the Radix Bupleuri distillation merges, be concentrated into relative density and be 1.38～1.40 extractum, spray-dried dry extract; B. with the volatile oil cyclodextrin inclusion compound of aforementioned Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, Radix Bupleuri, spray-driedly must do the enclose powder; C. with aforesaid dry extract and dried enclose powder mix homogeneously, add an amount of carboxymethyl starch sodium and starch and do adjuvant, make behind the granule repress and make sheet and get final product.
The specific embodiment eight: the preparation method of the traditional Chinese compound medicine oral liquid of present embodiment treatment chronic pelvic inflammatory disease is: a. is with Fructus Forsythiae 60～90g, Cortex Moutan 45～75g, Rhizoma Curcumae 60～90g, Rhizoma Cyperi 45～75g, Radix Bupleuri 45～75g decocts with water after mixing, extract volatile oil, aqueous solution after distillation device is in addition collected, with the surplus medicinal residues of institute and Flos Lonicerae 130～170g, Radix Paeoniae Rubra 70～110g, Radix Scutellariae 60～90g, Semen Persicae 20～45g, Rhizoma Corydalis 45～75g, Sargassum 60～90g, Concha Ostreae 35～70g, Semen Coicis 60～90g, Spina Gleditsiae 45～75g decocts with water twice after mixing, each 1～3 hour, collecting decoction, filter, then with filtrate and Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, aqueous solution after the Radix Bupleuri distillation merges, and is concentrated into relative density and is 1.38～1.40 extractum; B. adding the concentration account for 4～6 times of extractum volumes and be 50～80% ethanol in aforementioned extractum stirs, static 20～26 hours, preferably after 24 hours, getting supernatant filters with the microporous filter membrane of 0.4～0.8 μ, centrifugal, be evaporated to proportion and be 1.10～1.30 extractum, thin up to 500～800ml, and then cold preservation 20～26 hours, preferably after 24 hours, getting supernatant filters the back with the microporous filter membrane of 0.4～0.8 μ and adds aforementioned Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, the volatile oil of Radix Bupleuri and an amount of antiseptic, add an amount of water, stir evenly filtration and get final product.
One, with the Mus is the pharmacodynamics test of object
[test one] medicine of the present invention is to the influence of mouse peritoneal inflammation
Experimental technique: get some healthy male mices, body weight is divided into 6 groups at random between 18～22 grams, be respectively high, medium and low three the dosage groups of granule of the present invention, " Fubao " instant granular preparation group, hydrocortisone matched group and normal control group.Except that hydrogenation cortisone group intraperitoneal administration, all the other respectively organize equal oral administration gavage administration, each organizes after the administration 40 minutes, with the blue 4.0mg/kg tail vein injection of 1% she Wen, and while lumbar injection 0.25% acetic acid 0.4ml/10g, sacrificed by decapitation after 30 minutes, blood-letting, cut open the belly, every animal abdominal part is sagging, wash the abdominal cavity repeatedly with an amount of distilled water, collect washing liquid and adjust to 10ml, move into scale in vitro, centrifugal 2500 rev/mins, discard precipitate after 10 minutes, supernatant adds 0.1N sodium peroxide 0.1ml, surveys its optical density with spectrophotometer 590nm, obtains she Wen's seepage discharge by standard curve.
Experimental result sees the following form
| Group | Example number (only) | Dosage (/kg) | The blue seepage discharge of she Wen (x ± SD/kg) |
| Granule of the present invention | ?????10 | ?????20g | ????????2.76±0.67 ※※ |
| Granule of the present invention | ?????10 | ?????10g | ????????2.79±0.84 ※※ |
| Granule of the present invention | ?????11 | ?????5g | ????????3.44±0.92 ※※ |
| " Fubao " instant granular preparation | ?????11 | ?????10g | ????????4.51±0.99 ※※ |
| Hydrocortisone | ?????11 | ?????30mg | ????????2.14±0.72 ※※ |
| Normal control | ?????12 | ?????30ml | ????????5.49±1.25 ※※ |
Annotate: compare with the normal control group,
※P＜0.05,
※ ※P＜0.01; Compare with the precious group of woman,
ΔP＜0.05,
The Δ ΔP＜0.01.
By last table result as seen, each administration group is compared with matched group, and the seepage discharge of her Wen orchid is all had the obvious suppression effect, and (p＜0.05 or p＜0.01 is the best with the hydrocortisone group, secondly is each dosage group of granule of the present invention.Each dosage group of granule of the present invention is compared with the precious group of woman also has evident difference, illustrates that her the oozing out of Wen orchid of mice that granule Dichlorodiphenyl Acetate of the present invention causes has the obvious suppression effect, and its effect is more precious than the woman to be good, but not as good as the hydrocortisone group.
[test two] medicine of the present invention is to the influence of rat intestine adhesion
The intestinal adhesion clinical manifestation is with knowing that block up disease conforms to, and as abdominal mass, the abdomen localized pain is also seen hemorheology variation etc.So can manually make the animal intestine adhesion as the Blood stasis pathological model.
Experimental technique: getting some, body weight is the female rat of 300 ± 20 grams, place and be full of in the ether gas container after the anesthesia, the abdominal part cropping, sterilization, under aseptic condition, perform the operation, vertically cut 3～4cm otch along the abdomen median line, after finding vermiform appendix, at distance vermiform appendix cecum 0.5cm place, do the long stringer holostrome mouth of a 2.0～2.5cm, clean the feces of vermiform appendix intracavity with aseptic absorbent cotton full scale clearance, again otch is sewed up (notching edge ploughs under the vermiform appendix intracavity fully) with No. 1 silk thread densification, two-layer pass abdomen gets final product.
And rat is divided into 5 groups at random after will performing the operation, and is respectively granule 10g/kg of the present invention, 5g/kg group, " Fubao " instant granular preparation 10g/kg group, hydrocortisone 30g/kg group and model group 30ml/kg ordinary water.The hands second day after operation, each group is oral administration (hydrocortisone group intraperitoneal administration) respectively, every day 1 time, continuous 7 days.Sacrifice of animal was cut open the belly in the 8th day, observe intestinal adhesion degree, adhesion incidence rate and average adhesion place number.Adhesion grading standard is as follows: "+" single place's adhesion, and matter is crisp, can't get specimen; " ++ " single place's adhesion firmly, is easily got specimen; " +++" adhesion of two places, firmly, easily get specimen; " ++ ++ " the above adhesion in three places, firmly, easily get specimen.
Experimental result sees the following form:
| The group number | Example number (only) | Dosage (/kg) | Adhesion example number (only) | Adhesion incidence rate (%) | The adhesion degree | Average adhesion place | |||
| ??+ | ???++ | ??+++ | ?++++ | ||||||
| Granule of the present invention | ???10 | ???10g | ??4 ※※ | ????40.0 | ??3 | ???1 | ???0 | ???0 | ???0.40 |
| Granule of the present invention | ???9 | ???5g | ??6 | ????66.7 | ??4 | ???1 | ???1 | ???0 | ???0.78 |
| " Fubao " instant granular preparation | ???8 | ???10g | ??4 | ????50.0 | ??2 | ???1 | ???1 | ???0 | ???0.63 |
| Hydrocortisone | ???10 | ???30mg | ??2 ※※ | ????20.0 | ??1 | ???1 | ???0 | ???0 | ???0.20 |
| Model | ???9 | ???30ml | ??9 | ????100 | ??2 | ???3 | ???3 | ???1 | ???1.56 |
Annotate: compare with model
※ ※P＜0.01
Last table result shows, adopts said method can cause rat intestine adhesion model (intestinal adhesion all takes place model).Each administration group adhesion example number is compared with model group, and through the X2 check, granule 10g/kg group of the present invention and hydrocortisone group all have evident difference (P＜0.01), and all the other two groups of effects are not obvious.Observe from the adhesion degree, each administration group forms adhesion, the adhesion degree of large intestine also than model group be light (because of the routine number of each administration group very little, can't statistical disposition).From average adhesion number, each administration group is few according to model group all.Above-mentioned experimental result shows that granule of the present invention has certain anti-experimental character rat intestine adhesion effect.
Pharmacodynamic experiment with artificial object:
One, case choice criteria
Be total to undergoing chronic pelvic inflammation 113 examples of observing.Age distribution: 18～30 years old 19 people, 30～40 years old 46 people, 40～50 years old 48 people; The state of an illness distributes: light-53 people, in-47 people, heavy-1 3 people.
Two, the diagnostic criteria of disease
1. the Western medicine diagnose standard of chronic pelvic inflammatory disease:
(1) symptom:
A. how not obvious General Symptoms is, and low grade fever is only arranged sometimes, the tired grade of susceptible disease, and neurasthenia symptom can appear in course of disease elder's part patient, and as lassitude, the whole body is uncomfortable, diseases such as insomnia.
B. chronic inflammatory disease forms cicatricial adhesion or pelvic congestion, sagging distention in the smaller abdomen, pain can occur, and the lumbosacral region swelling and pain is after the fatigue of being everlasting, the sexual intercourse, increase the weight of before and after the menstruation.
C. chronic inflammatory disease causes pelvic congestion, or influences ovarian function, can cause menoxenia, sees with menorrhagia or menostaxis more; Leucorrhoea grow in quantity can be arranged, be yellow or yellowish water sample; The fallopian tube adhesion obstruction can cause infertile.
(2) sign: the uterus often is the hypsokinesis position, and limitation of activity or adhesion are fixed, and during myometritis, can there be tenderness in the uterus; If salpingitis then touches in the one or both sides, uterus and streakly increases thick fallopian tube, and mild tenderness is arranged; If hydrosalpinx or tubo-ovarian cyst are then touched the swollen thing of capsule in the pelvic cavity one or both sides, how limited activity is, and mild tenderness can be arranged; If during the inflammation of pelvic cavity connective tissue, the one or both sides, uterus have that lamellar thickens, tenderness, or have that uterosacral ligament increases slightly, hardening, tenderness.
Above-mentioned sign need possess following 2 at least simultaneously: the limited or adhesion of uterine activity is fixed; The attachment area tenderness.
2, the Chinese medical discrimination diagnostic criteria of chronic pelvic inflammatory disease:
Primary symptom: a. inferior belly gas pain or twinge, sore spot is fixed; B. waist sacrum distending pain; C. profuse leukorrhea, yellow skin matter is thick, frowziness.
Inferior disease: a. abdominal pain during menstruation increases the weight of, and menstruation increases piece, menostaxis, and spiritlessness and weakness, constipation due to dry stool or half congealed and not well, yellow urine, waste heat do not eliminate or hang down thermal fluctuation.
The tongue arteries and veins: red tongue or dark red, or see petechia or ecchymosis, and yellow and greasy fur or white greasy, slippery and rapid pulse or stringy and rapid pulse or stringy and rolling pulse or string are puckery.
Above primary symptom possesses 2, and inferior disease possesses 2, and is promptly diagnosable in conjunction with picture of the tongue, pulse condition.
Three, medication ingredient: use medicine of the present invention, promptly contain the granule of Flos Lonicerae 130～170g, Radix Paeoniae Rubra 70～110g, Radix Scutellariae 60～90g, Fructus Forsythiae 60～90g, Cortex Moutan 45～75g, Semen Persicae 20～45g, Rhizoma Curcumae 60～90g, Rhizoma Cyperi 45～75g, Rhizoma Corydalis 45～75g, Sargassum 60～90g, Concha Ostreae 35～70g, Semen Coicis 60～90g, Spina Gleditsiae 45～75g, Radix Bupleuri 45～75g.
Four, administrated method: with granule pack of the present invention, every bag of 10g, when taking, 2 bags/time, 2 times/day, 4 weeks were a course of treatment, took a course of treatment.
Five, curative effect judging standard
1, the disconnected standard of tcm symptom curative effect
With reference to the nimodipine method: [(integration before the treatment-treatment back integration)/preceding integration of treatment] * 100%
Clinical recovery: the tcm symptom integration reduces 〉=90%
Produce effects: the tcm symptom integration reduces 〉=70%
Progressive: the tcm symptom integration reduces 〉=30%
Invalid: the tcm symptom integration reduces＜30%
2, local sign efficacy assessment standard:
Clinical recovery: the local sign in treatment back disappears, and integration is 0.
Produce effects: the local sign in treatment back obviously alleviates, and reduces 〉=2/3 than integration before the treatment after the treatment.
Progressive: the local sign in treatment back alleviates to some extent, the treatment back before the treatment integration reduce 〉=1/3 and＜2/3.
Invalid: treatment back sign does not have to improve or have and increases the weight of, the treatment back before the treatment integration reduce＜1/3.
Six, efficacy result analysis:
Curative effect with prescription treatment chronic pelvic inflammatory disease of the present invention sees the following form:
To sum up, through clinical observation, with product treatment pelvic inflammatory disease of the present invention, no matter patient's tcm symptom or local sign all obtained curative effect preferably, the tcm symptom curative effect: cure-remarkable-effectiveness rate is 45.13%, and total effective rate is 95.58%; Local sign curative effect: cure-remarkable-effectiveness rate is 60.18%, and total effective rate is 88.50%.
Claims (9)
1, a kind of traditional Chinese compound medicine for the treatment of chronic pelvic inflammatory disease, it is characterized in that it comprises following composition: Flos Lonicerae, Radix Paeoniae Rubra, Radix Scutellariae, Fructus Forsythiae, Cortex Moutan, Semen Persicae, Rhizoma Curcumae, Rhizoma Cyperi, Rhizoma Corydalis, Sargassum, Concha Ostreae, Semen Coicis, Spina Gleditsiae, Radix Bupleuri, the gram number of each composition is: Flos Lonicerae 130～170g, Radix Paeoniae Rubra 70～110g, Radix Scutellariae 60～90g, Fructus Forsythiae 60～90g, Cortex Moutan 45～75g, Semen Persicae 20～45g, Rhizoma Curcumae 60～90g, Rhizoma Cyperi 45～75g, Rhizoma Corydalis 45～75g, Sargassum 60～90g, Concha Ostreae 35～70g, Semen Coicis 60～90g, Spina Gleditsiae 45～75g, Radix Bupleuri 45～75g.
2, the traditional Chinese compound medicine of treatment chronic pelvic inflammatory disease according to claim 1 is characterized in that the gram number of each composition is: Flos Lonicerae 135～145g, Radix Paeoniae Rubra 75～85g, Radix Scutellariae 65～75g, Fructus Forsythiae 65～75g, Cortex Moutan 50～55g, Semen Persicae 25～30g, Rhizoma Curcumae 65～70g, Rhizoma Cyperi 50～60g, Rhizoma Corydalis 50～55g, Sargassum 65～70g, Concha Ostreae 40～50g, Semen Coicis 65～70g, Spina Gleditsiae 50～55g, Radix Bupleuri 50～55g.
3, the traditional Chinese compound medicine of treatment chronic pelvic inflammatory disease according to claim 1 is characterized in that the gram number of each composition is: Flos Lonicerae 150～155g, Radix Paeoniae Rubra 90～95g, Radix Scutellariae 80～85g, Fructus Forsythiae 80～85g, Cortex Moutan 60～65g, Semen Persicae 35～40g, Rhizoma Curcumae 75～80g, Rhizoma Cyperi 65～70g, Rhizoma Corydalis 60～70g, Sargassum 75～80g, Concha Ostreae 55～60g, Semen Coicis 75～80g, Spina Gleditsiae 60～65g, Radix Bupleuri 60～65g.
4, the traditional Chinese compound medicine of treatment chronic pelvic inflammatory disease according to claim 1 is characterized in that the gram number of each composition is: Flos Lonicerae 160～165g, Radix Paeoniae Rubra 100～105g, Radix Scutellariae 86～89g, Fructus Forsythiae 86～89g, Cortex Moutan 66～74g, Semen Persicae 41～44g, Rhizoma Curcumae 81～89g, Rhizoma Cyperi 71～74g, Rhizoma Corydalis 71～74g, Sargassum 81～89g, Concha Ostreae 61～69g, Semen Coicis 81～89g, Spina Gleditsiae 70～74g, Radix Bupleuri 70～74g.
5, the traditional Chinese compound medicine of treatment chronic pelvic inflammatory disease according to claim 1 is characterized in that the gram number of each composition is: Flos Lonicerae 150g, Radix Paeoniae Rubra 90g, Radix Scutellariae 75g, Fructus Forsythiae 75g, Cortex Moutan 60g, Semen Persicae 35g, Rhizoma Curcumae 75g, Rhizoma Cyperi 60g, Rhizoma Corydalis 60g, Sargassum 75g, Concha Ostreae 50g, Semen Coicis 75g, Spina Gleditsiae 60g, Radix Bupleuri 60g.
6, a kind of preparation method for the treatment of the traditional Chinese compound medicine granule of chronic pelvic inflammatory disease is characterized in that:
A. with Fructus Forsythiae 60～90g, Cortex Moutan 45～75g, Rhizoma Curcumae 60～90g, Rhizoma Cyperi 45～75g, Radix Bupleuri 45～75g decocts with water after mixing, extract volatile oil, aqueous solution after distillation device is in addition collected, with the surplus medicinal residues of institute and Flos Lonicerae 130～170g, Radix Paeoniae Rubra 70～110g, Radix Scutellariae 60～90g, Semen Persicae 20～45g, Rhizoma Corydalis 45～75g, Sargassum 60～90g, Concha Ostreae 35～70g, Semen Coicis 60～90g, Spina Gleditsiae 45～75g decocts with water twice after mixing, each 1～3 hour, collecting decoction, filter, then with filtrate and Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, aqueous solution after the Radix Bupleuri distillation merges, be concentrated into relative density and be 1.38～1.40 extractum, spray-dried dry extract;
B. with the volatile oil cyclodextrin inclusion compound of aforementioned Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, Radix Bupleuri, spray-driedly must do the enclose powder;
C. with aforesaid dry extract and dried enclose powder mix homogeneously, add an amount of sucrose as adjuvant, mixing is drying to obtain granule.
7, a kind of capsular preparation method of traditional Chinese compound medicine for the treatment of chronic pelvic inflammatory disease is characterized in that:
A. with Fructus Forsythiae 60～90g, Cortex Moutan 45～75g, Rhizoma Curcumae 60～90g, Rhizoma Cyperi 45～75g, Radix Bupleuri 45～75g decocts with water after mixing, extract volatile oil, aqueous solution after distillation device is in addition collected, with the surplus medicinal residues of institute and Flos Lonicerae 130～170g, Radix Paeoniae Rubra 70～110g, Radix Scutellariae 60～90g, Semen Persicae 20～45g, Rhizoma Corydalis 45～75g, Sargassum 60～90g, Concha Ostreae 35～70g, Semen Coicis 60～90g, Spina Gleditsiae 45～75g decocts with water twice after mixing, each 1～3 hour, collecting decoction, filter, then with filtrate and Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, aqueous solution after the Radix Bupleuri distillation merges, be concentrated into relative density and be 1.38～1.40 extractum, spray-dried dry extract;
B. with the volatile oil cyclodextrin inclusion compound of aforementioned Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, Radix Bupleuri, spray-driedly must do the enclose powder;
C. with aforesaid dry extract and dried enclose powder mix homogeneously, add appropriate amount of starch as adjuvant, mixing incapsulates promptly.
8, a kind of preparation method for the treatment of the traditional Chinese compound medicine tablet of chronic pelvic inflammatory disease is characterized in that:
A. with Fructus Forsythiae 60～90g, Cortex Moutan 45～75g, Rhizoma Curcumae 60～90g, Rhizoma Cyperi 45～75g, Radix Bupleuri 45～75g decocts with water after mixing, extract volatile oil, aqueous solution after distillation device is in addition collected, with the surplus medicinal residues of institute and Flos Lonicerae 130～170g, Radix Paeoniae Rubra 70～110g, Radix Scutellariae 60～90g, Semen Persicae 20～45g, Rhizoma Corydalis 45～75g, Sargassum 60～90g, Concha Ostreae 35～70g, Semen Coicis 60～90g, Spina Gleditsiae 45～75g decocts with water twice after mixing, each 1～3 hour, collecting decoction, filter, then with filtrate and Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, aqueous solution after the Radix Bupleuri distillation merges, be concentrated into relative density and be 1.38～1.40 extractum, spray-dried must be in extract powder;
B. with the volatile oil cyclodextrin inclusion compound of aforementioned Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, Radix Bupleuri, spray-driedly must do the enclose powder;
C. with aforesaid dry extract and dried enclose powder mix homogeneously, add an amount of carboxymethyl starch sodium and starch and do adjuvant, mixing is made behind the granule repress and is made sheet and get final product.
9, a kind of preparation method for the treatment of the traditional Chinese compound medicine oral liquid of chronic pelvic inflammatory disease is characterized in that:
A. with Fructus Forsythiae 60～90g, Cortex Moutan 45～75g, Rhizoma Curcumae 60～90g, Rhizoma Cyperi 45～75g, Radix Bupleuri 45～75g decocts with water after mixing, extract volatile oil, aqueous solution after distillation device is in addition collected, with the surplus medicinal residues of institute and Flos Lonicerae 130～170g, Radix Paeoniae Rubra 70～110g, Radix Scutellariae 60～90g, Semen Persicae 20～45g, Rhizoma Corydalis 45～75g, Sargassum 60～90g, Concha Ostreae 35～70g, Semen Coicis 60～90g, Spina Gleditsiae 45～75g decocts with water twice after mixing, each 1～3 hour, collecting decoction, filter, then with filtrate and Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, aqueous solution after the Radix Bupleuri distillation merges, and is concentrated into relative density and is 1.38～1.40 extractum;
B. adding the concentration account for 4～6 times of extractum volumes and be 50～80% ethanol in aforementioned extractum stirs, after static 20～26 hours, get supernatant filter, centrifugal, to be evaporated to proportion be 1.10～1.30 extractum, thin up to 500～800ml, cold preservation is 20～26 hours then, filters, and filtrate adds the volatile oil of aforementioned Fructus Forsythiae, Cortex Moutan, Rhizoma Curcumae, Rhizoma Cyperi, Radix Bupleuri and an amount of antiseptic, add an amount of water, stir evenly filtration promptly.
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| CNA031116884A CN1548065A (en) | 2003-05-14 | 2003-05-14 | Compound Chinese medicine for treating chronic pulvic infection and prepn process of its prepn forms |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091211A (en) * | 2010-12-06 | 2011-06-15 | 济南金鼎信息技术有限公司 | Traditional Chinese medicine composition for treating pelvic inflammation |
| CN101849999B (en) * | 2009-03-31 | 2012-05-23 | 江苏康缘药业股份有限公司 | Traditional Chinese medicine composition for treating pelvic inflammation and preparation method thereof |
| CN102600440A (en) * | 2012-03-29 | 2012-07-25 | 常熟市常福有机复合肥有限公司 | Chinese herbal composition for treating chronic pelvic inflammation and preparation method thereof |
| CN104857127A (en) * | 2015-06-15 | 2015-08-26 | 青岛华仁技术孵化器有限公司 | Oral administration medicine used for curing accumulated damp heat type chronic pelvic inflammatory disease |
| CN110652573A (en) * | 2019-10-31 | 2020-01-07 | 韩佳良 | Traditional Chinese medicine composition for treating chronic pelvic inflammatory disease and preparation method and application thereof |
-
2003
- 2003-05-14 CN CNA031116884A patent/CN1548065A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101849999B (en) * | 2009-03-31 | 2012-05-23 | 江苏康缘药业股份有限公司 | Traditional Chinese medicine composition for treating pelvic inflammation and preparation method thereof |
| CN102091211A (en) * | 2010-12-06 | 2011-06-15 | 济南金鼎信息技术有限公司 | Traditional Chinese medicine composition for treating pelvic inflammation |
| CN102091211B (en) * | 2010-12-06 | 2012-01-25 | 张敏 | Traditional Chinese medicine composition for treating pelvic inflammation |
| CN102600440A (en) * | 2012-03-29 | 2012-07-25 | 常熟市常福有机复合肥有限公司 | Chinese herbal composition for treating chronic pelvic inflammation and preparation method thereof |
| CN104857127A (en) * | 2015-06-15 | 2015-08-26 | 青岛华仁技术孵化器有限公司 | Oral administration medicine used for curing accumulated damp heat type chronic pelvic inflammatory disease |
| CN110652573A (en) * | 2019-10-31 | 2020-01-07 | 韩佳良 | Traditional Chinese medicine composition for treating chronic pelvic inflammatory disease and preparation method and application thereof |
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