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CN1299728C - Capsules of Tokyo violet, dandelion and flavescent sophora root and their making method - Google Patents

Capsules of Tokyo violet, dandelion and flavescent sophora root and their making method Download PDF

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Publication number
CN1299728C
CN1299728C CNB2005100416658A CN200510041665A CN1299728C CN 1299728 C CN1299728 C CN 1299728C CN B2005100416658 A CNB2005100416658 A CN B2005100416658A CN 200510041665 A CN200510041665 A CN 200510041665A CN 1299728 C CN1299728 C CN 1299728C
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China
Prior art keywords
fructus
capsule
dandelion
standby
capsules
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Expired - Fee Related
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CNB2005100416658A
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CN1679834A (en
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王四旺
黄传贵
谢艳华
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Pharmaceutic Inst No 4 Millitary Medical Univ P L A
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Pharmaceutic Inst No 4 Millitary Medical Univ P L A
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Abstract

The present invention relates to a capsule of Tokyo violet, dandelion and flavescent sophora root and a making method thereof and provides a pure Chinese medicine and a production process thereof for patients with hyperplasia of prostate. The Chinese medicinal preparation is prepared from ten Chinese herbs of philippine violet herb, dandelion, lightyellow sophora root, etc. and cyclodextrin, the production process of the capsule of Tokyo violet, dandelion and flavescent sophora root comprises: cassia bark is powdered, inclusion compounds of volatile oil of fennel are extracted, the materials are mixed, are decocted, and are granulated, the granules are placed in capsules, and the capsules are formed. The capsule has the advantages of standard and easy preparation process, low production cost and convenient oral administration and has obvious therapeutic effect on the hyperplasia of prostate of old people.

Description

Purple Pu ginseng capsule and preparation technology thereof
Affiliated technical field
Purple Pu ginseng capsule of the present invention and preparation technology thereof belong to medicine and the preparation technology thereof who treats surgical diseases, relate in particular to pure Chinese medicinal preparation and preparation technology thereof with Chinese prescription treatment middle-aged and elderly people prostatic hyperplasia.
Background technology
Man more than 50 years old, benign prostate undue growth is to cause the common cause of bladder outlet infraction, the symptom of benign prostatic hyperplasia is mechanical obstruction and the symptom that produces urinary retention then, it is early stage that prostate increases, the urgent micturition frequent micturition appears in patient, urine thin and unable, the residual urine sense is arranged, and along with increasing the weight of of blocking, the increase body of gland pressure under the trigone of urinary bladder increases, the controlled micturition number of times is increased, the nocturia showed increased, along with prostatic continuous increase, the elongation of prostate-urethra portion, bore increases, the trigone of urinary bladder displacement causes that the bottom ureter presents the fish hook shape and changes, the loose companion of wall of urinary bladder girder, houselet forms, make the opening of bladder complete obstruction can cause detrusor to lose decompensation and urine retention, make little angiorrhexis congested on the loose prostate mucosa hemorrhage owing to the patient will firmly urinate, not only make the patient hematuria symptom occur, also can due to infecting, the purulence cystitis occur, more be prone to vesical calculus, also can cause hydronephrosis when more serious, urinary tract infection, impaired renal function.Infection of treatment prostate and carcinoma of prostate disease drug are more at present, the active drug of treatment person in middle and old age benign prostatic hyperplasia symptom in early stage is less, often cause the prostatic hyperplasia mechanical obstruction symptom fast development in early stage, hematuria and dense cystitis and vesical calculus symptom appear very soon, the patient suffering is strengthened, and the prolongation of treatment phase, medical expense increases, and market demand is effectively treated middle-aged and elderly people prostatic hyperplasia medicine.
Summary of the invention
The objective of the invention is: suffering from the prostatic hyperplasia patient to middle-aged and elderly people provides scientific formulation, can reach heat-clearing and toxic substances removing, the pure Chinese medicinal preparation of softening hardness and disperse swelling, the liver soothing and the spleen invigorating, promoting blood circulation and stopping pain effect, can effectively cure patient's urgent micturition frequent micturition, urine thin, unable, residual urine sense and urinary incontinence symptom arranged, avoid PD to enlarge, and have no side effect, with low cost, production technology is easy, and curative effect is outstanding.
In order to realize the foregoing invention purpose, the technical solution adopted in the present invention is: purple Pu ginseng capsule is according to the main etiology and pathogenesis of middle-aged and elderly people prostatic hyperplasia, with heat-clearing and toxic substances removing, softening hardness and disperse swelling, the liver soothing and the spleen invigorating, promoting blood circulation and stopping pain are principle of treatment, the crude drug total amount is 1080 grams in the prescription, form, and make adjuvant by Herba Violae and each 140 gram of Herba Taraxaci and Radix Sophorae Flavescentis, Rhizoma Corydalis, Fructus Toosendan, Poria, Semen Trigonellae, Fructus Foeniculi, Cortex Cinnamomi, each 100 gram of Fructus Cnidii with an amount of beta-schardinger dextrin-.The preparation technology who prepares purple Pu ginseng capsule is divided into Cortex Cinnamomi powder process, Fructus Foeniculi proposes volatile oil and uses the dextrin enclose, all the other medicines decoct produces thick paste, mixing granulation, dress capsule five road technologies, getting Cortex Cinnamomi earlier pulverized 100 mesh sieves and becomes the fine powder medicine standby, and adopt the way of distillation to extract volatile oil the Fructus Foeniculi, and it is standby with cyclodextrin inclusion compound, again the Fructus Foeniculi medicinal residues, Herba Violae, Herba Taraxaci, Radix Sophorae Flavescentis, Rhizoma Corydalis, Fructus Toosendan, Poria, Semen Trigonellae, Fructus Cnidii adds 10 times and 8 times of decoctings respectively and boils secondary, soaked 1 hour earlier before decocting for the first time, decocted again 1.5 hours, decocted 1 hour for the second time, filter respectively, merging filtrate, be evaporated to the thick paste of relative density about 1.30 (80 ℃), with thick paste and standby fine powder medicine and the mixing of Fructus Foeniculi volatile oil clathrate, stir at last, through 80 ℃ of following temperature bakings, steaming is made soft material after taking off too much moisture content, cross 14 order nylon mesh and granulate, again through temperature drying below 80 ℃, No. 1 capsule of packing into gets patent medicine.Chinese medicine thinks that person in middle and old age's prostatic hyperplasia is divided into syndrome of dampness-heat in lower jiao, phlegm-heat closed lung card, blood-stasis syndrome.Middle Qi collapse syndrome, kidney yang deficiency card, the pathogenesis that gets to the bottom of sb.'s illness, how weak with age, damp-heat in lower-JIAO, caused by liver and kidney deficiency, deficiency-weakness of spleen-QI, urinary tract be obstructed, due to the stagnation of QI in chest and abdomen, urticaria pyretic toxicity urticaria, damp-heat accumulation bladder, and modern Chinese medicine research confirms; In purple Pu ginseng capsule prescription, Herba Violae has heat-clearing and toxic substances removing, removing heat from blood detumescence, passes through and let out fire, diffusing swollen detoxicating function; Herba Taraxaci has heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, diuresis, spleen reinforcing lung heat clearing function; Radix Sophorae Flavescentis has heat clearing and damp drying, pathogenic wind expelling, detumescence poison, expectorant poison effect; Rhizoma Corydalis tool promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain, invigorate blood circulation, the diuresis function; Fructus Toosendan has soothing the liver heat, promoting the circulation of QI to relieve pain, diuresis, logical large intestine, the heat radiation knot function of secreting; Poria has promoting diuresis to eliminate damp pathogen, invigorating the spleen and regulating the stomach, only quenches one's thirst, the diuresis effect; Semen Trigonellae has the kidney warming sun, pursues the cold-damp function; Fructus Foeniculi has the warm liver of warming the kidney, promoting the circulation of QI to relieve pain, the treatment bladder function that swells and ache; Cortex Cinnamomi have mend that fire is supporing yang, let the fire back to its origin, dispersing cold for relieving pain, warming the meridian and promoting blood circulation, go into the heart and draw the dense effect of blood antiperspirantization; Fructus Cnidii has warming the kidney to invigorate YANG, dispeiling pathogenic wind and removing dampness function.All medicines side of closing, play heat-clearing and toxic substances removing, softening hardness and disperse swelling, easypro swollen spleen invigorating, promoting blood circulation and stopping pain effect altogether, effectively treatment holds the prostata tissue hypertrophy of back urethra, the recovery urethra is unobstructed, realize middle-aged and elderly people prostatic hyperplasia patient's urgent micturition frequent micturition, thin, the unable symptom rapid healing of urine line, residual urine sense and the also disappearance thereupon of urinary incontinence symptom is arranged.
To cure mainly relevant pharmacodynamics test verified evident in efficacy with function in preclinical study for purple Pu ginseng capsule, and recommending clinical adult's oral dose is 3 times on the one, and each 4,6 weeks were 1 course of treatment.
The invention has the beneficial effects as follows: prescription rationally, preparation technology's standard, by the effective ingredient complementation, purple Pu ginseng capsule has heat-clearing and toxic substances removing, softening hardness and disperse swelling, the liver soothing and the spleen invigorating, promoting blood circulation and stopping pain effect, can effectively treat the middle-aged and elderly people prostatic hyperplasia, and have no side effect, evident in efficacy, production technology is easy, low production cost, taking convenience.
Specific embodiments:
1, purple Pu ginseng capsule prescription is made up of ten flavor Chinese herbal medicine, wherein Herba Violae and Herba Taraxaci respectively 140 restrain, Radix Sophorae Flavescentis, Rhizoma Corydalis, Fructus Toosendan, Poria, Semen Trigonellae, Fructus Foeniculi, Cortex Cinnamomi, each 100 gram of Fructus Cnidii, weighing is standby respectively behind the equal enchashment row of each Chinese herbal medicine prepared slices of Chinese crude drugs roguing well sifted; And it is standby to get the adjuvant beta-schardinger dextrin-.
2, purple Pu ginseng capsule preparation technology:
1. getting Cortex Cinnamomi pulverized 100 mesh sieves and becomes the fine powder medicine standby.
2. get Fructus Foeniculi and adopt the way of distillation to extract volatile oil, and beta-schardinger dextrin-is mixed with saturated aqueous solution, make bag and thing and medicinal residues with 1: 1 adding Fructus Foeniculi volatile oil and distinguish standby.
3. get Herba Violae, Herba Taraxaci, Radix Sophorae Flavescentis, Rhizoma Corydalis, Fructus Toosendan, Poria, Semen Trigonellae, Fructus Cnidii and Fructus Foeniculi medicinal residues and decoct with water secondary, add for the first time 10 times of water, soak to decoct after 1 hour and filtered in 1.5 hours, for the second time add 8 times of decoctings and boil filtration in 1 hour, merging filtrate, the thick paste that is evaporated to relative about 1.30 (80 ℃) is standby.
4. standby thick paste, fine powder medicine, Fructus Foeniculi volatile oil clathrate are mixed, stir, after excess moisture is taken off in 80 ℃ of following temperature steamings, make soft material, cross 14 order nylon mesh and granulate, through 80 ℃ of following temperature oven dry, divide No. 1 capsule of packing into to get patent medicine again.

Claims (2)

1, a kind of purple Pu ginseng capsule, it is characterized in that: the crude drug total amount is 1080 grams in the prescription, form, and make adjuvant by Herba Violae and each 140 gram of Herba Taraxaci and Radix Sophorae Flavescentis, Rhizoma Corydalis, Fructus Toosendan, Poria, Semen Trigonellae, Fructus Foeniculi, Cortex Cinnamomi, each 100 gram of Fructus Cnidii with powder-beta-dextrin.
2, purple according to claim 1 Pu ginseng capsule preparation technology, it is characterized in that: get Cortex Cinnamomi earlier and pulverized 100 mesh sieves and become the fine powder medicine standby, and adopt the way of distillation to extract volatile oil the Fructus Foeniculi, and it is standby with cyclodextrin inclusion compound, again the Fructus Foeniculi medicinal residues, Herba Violae, Herba Taraxaci, Radix Sophorae Flavescentis, Rhizoma Corydalis, Fructus Toosendan, Poria, Semen Trigonellae, Fructus Cnidii adds 10 times and 8 times of decoctings respectively and boils secondary, soaked 1 hour earlier before decocting for the first time, decocted again 1.5 hours, decocted 1 hour for the second time, filter merging filtrate respectively, be evaporated in the time of 80 ℃ relative density and be 1.30 thick paste, with thick paste and standby fine powder medicine and the mixing of Fructus Foeniculi volatile oil clathrate, stir at last, through 80 ℃ of following temperature bakings, steaming is made soft material after taking off too much moisture content, cross 14 order nylon mesh and granulate, again through temperature drying below 80 ℃, No. 1 capsule of packing into gets patent medicine.
CNB2005100416658A 2005-01-31 2005-01-31 Capsules of Tokyo violet, dandelion and flavescent sophora root and their making method Expired - Fee Related CN1299728C (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101766734B (en) * 2008-12-30 2011-07-27 胡翠华 Medicine for treating prostatitis
CN114949084B (en) * 2022-07-15 2023-06-09 陕西方浩生物科技有限公司 A Chinese medicinal composition for treating prostatosis, and its preparation method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1304733A (en) * 2000-11-08 2001-07-25 赖德明 Medicine for treating prostatitis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1304733A (en) * 2000-11-08 2001-07-25 赖德明 Medicine for treating prostatitis

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