CN105106634A - Traditional Chinese medicine preparation for treating acute appendicitis and application thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine preparation for treating acute appendicitis, which is prepared from licorice, oldenlandia, snakegourd fruit, lobelia chinensis, chickweed, purslane, glabrous sarcandra herb, vernonia esculenta, galium aparine, stephanotis, pinellia tuber, common calanthe herb, drynaria, spatholobus stem, corydalis tuber, eclipta, common andrographis herb, hypericum japonicum, patrinia, cleavers, isatis root, pseudo-ginseng, dindygulen peperomia herb, luffa root, rhizoma acori graminei, rhubarb, bracken, finger citron, baikal skullcap root, carpet bugle, uncinate spikemoss herb, sowthistle-leaf ixeris seedling, officinal magnolia bark, bamboo fungus, long pepper and the like.

Description

A kind of Chinese medicine preparation and application thereof for the treatment of acute appendicitis

Technical field

The invention belongs to medical art, relate to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine preparation and application thereof for the treatment of acute appendicitis.

Background technology

Acute appendicitis is surgical common disease, occupies the first place of various acute abdomen.Transitivity right lower abdominal pain and McBurney's point tenderness, rebound tenderness are its common clinical manifestation, but the change of illness state multiterminal of acute appendicitis.Its clinical manifestation is the right lower abdominal pain, the Nausea and vomiting that continue the aggravation of companion's paroxysmal, and most patient's leukocyte and neutrophil count increase.Right Lower Abdomen vermiform appendix district (mcBurney point) tenderness is then this sick vital sign.Acute appendicitis generally divides Four types: acute simple appendicitis, acute suppurative appendicitis, gangrene and perforating appendicitis and periappendiceal abscess.

The clinical manifestation of acute appendicitis has:

1. suffer from abdominal pain, there are middle upper abdomen or all pain of umbilicus at the typical acute appendicitis initial stage, and after a few hours, stomachache shifts and is fixed on Right Lower Abdomen.Commitment is a kind of visceral nerve reflexive pain, therefore middle upper abdomen and the comparatively disperse of umbilicus week pain dimensions, Chang Buneng definitely locates.When inflammation involves placenta percreta and parietal peritoneum, namely pain be fixed on Right Lower Abdomen, and namely former middle upper abdomen or pain around the navel alleviate or disappear.Therefore, without typical transitivity Right Lower Abdomen history of pain can not except acute appendicitis; Simple appendicitis is often in paroxysmal or persistence distending pain with dull pain, and persistence severe pain often prompts for suppurative or gangrenous appendicitis.Lasting severe pain involves middle lower abdomen or both sides lower abdomen, is often the sign of vermiform appendix gangrene perforation.Sometimes vermiform appendix gangrene perforation, stomachache is alleviated on the contrary to some extent, but the phenomenon of this pain relief is temporary transient, and other adjoint sings and symptomses do not improve, and aggravate even to some extent.

2. gastrointestinal symptom, the gastrointestinal symptom of simple appendicitis is not given prominence to.Nausea and vomiting may be had in early days due to reflexive stomach spasm.Pelvic cavity position appendicitis or vermiform appendix gangrene perforation can have defecation frequency to increase.

3. generate heat, generally only have low grade fever, without shiver with cold, suppurative appendicitis is generally also no more than 38 DEG C.High overabundant heat sees vermiform appendix gangrene, perforation or Complicating Peritonitis.With shiver with cold and jaundice, then prompting may concurrent suppurative pylephlebitis.

4. tenderness and rebound tenderness, abdominal tenderness is the performance that parietal peritoneum is subject to inflammatory stimulus.Namely in right anterior superior iliac spine and umbilicus line, outer 1/3 intersection mcburney point is usually located at mcBurney point.With the variation of vermiform appendix anatomical position, pressure pain point can correspondingly change, but key is Right Lower Abdomen a fixing pressure pain point.Patient that is fat or retrocecally appendicitis, tenderness may be comparatively light, but have obvious rebound tenderness.

5. tension of abdominal muscle, namely vermiform appendix suppurates this sign, and during gangrene perforation Complicating Peritonitis, tension of abdominal muscle is particularly remarkable.But old or adiposis patient abdominal muscle is more weak, must check simultaneously pleurosternal muscle is contrasted, just can determine whether tension of abdominal muscle.

6. dermal sensation is irritated, in early days, especially have when blocking in vermiform appendix chamber, Right Lower Abdomen dermal sensation allergic phenomena can be there is, scope is equivalent to 10th ~ 12 breast myelomere section innervation districts, be positioned at the trigonum that right crista iliaca peak, right pubic crest and umbilicus are formed, it does not change because vermiform appendix position is different, as namely vermiform appendix gangrene perforation then disappears at the dermal sensation allergic phenomena of this trigonum.

In modern medicine, most sufferer all adopts surgical operation therapy, but has sequela unavoidably, and more patients are still ready to carry out expectant treatment with oral medicine.And western medical treatment late result is not good enough, be difficult to eliminate old complaint, and expensive, there is certain side effect.So to the medicine for the treatment of acute appendicitis must safety, effective, have no side effect, and Chinese materia medica is as the traditional medicine of China, there is the advantages such as effect is strong, instant effect, lasting medicine, and there is no dependency, drug resistance and toxic and side effects, therefore select a kind of Chinese medicine preparation to treat acute appendicitis, will there is very important clinical meaning for acute appendicitis.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation and application thereof for the treatment of acute appendicitis, selected by this Chinese medicine preparation, medical material compatibility is suitable, meet Chinese medicine and modern medicine theory, there is effect of heat-clearing and toxic substances removing, anti-inflammation, inducing diuresis to remove edema, detumescence and apocenosis, easy to use, good absorbing effect, without bad and toxic and side effects.

Above-mentioned purpose of the present invention is realized by following technical proposals:

Treat a Chinese medicine preparation for acute appendicitis, the crude drug of described Chinese medicine preparation is made up of Radix Glycyrrhizae, Herba Hedyotidis Diffusae, Fructus Trichosanthis, Herba Lobeliae Chinensis, Herba stellariae mediae, Herba Portulacae, Herba Sarcandrae, Herba Vernonia esculenta, Herba Galii Teneri, Radix Stephaniae Cepharanthae, the Rhizoma Pinelliae, Herba seu Radix Calanthes, Rhizoma Drynariae, Caulis Spatholobi, Rhizoma Corydalis, Herba Ecliptae, Herba Andrographis, Herba Hyperici Japonici, Herba Patriniae, Herba Galii Teneri, Radix Isatidis, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Herba Peperomiae Dindygulensis, Radix Luffae, Rhizoma Acori Graminei, Radix Et Rhizoma Rhei, Herba Pteridis Multifidae, Fructus Citri Sarcodactylis, Radix Scutellariae, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Herba Selaginellae Uncinatae, Herba Ixeritis Sonchifoliae, Cortex Magnoliae Officinalis, Caulis Bambusae In Taeniam, Fructus Piperis Longi etc.

Further, raw material composition and the parts by weight of making described Chinese medicine preparation are: Radix Glycyrrhizae 3-6 part, Herba Hedyotidis Diffusae 8-13 part, Fructus Trichosanthis 3-5 part, Herba Lobeliae Chinensis 11-15 part, Herba stellariae mediae 5-10 part, Herba Portulacae 2-5 part, Herba Sarcandrae 4-9 part, Herba Vernonia esculenta 12-20 part, Herba Galii Teneri 10-16 part, Radix Stephaniae Cepharanthae 3-8 part, Rhizoma Pinelliae 5-12 part, Herba seu Radix Calanthes 12-17 part, Rhizoma Drynariae 7-12 part, Caulis Spatholobi 4-9 part, Rhizoma Corydalis 15-20 part, Herba Ecliptae 10-15 part, Herba Andrographis 8-12 part, Herba Hyperici Japonici 2-5 part, Herba Patriniae 3-7 part, Herba Galii Teneri 11-14 part, Radix Isatidis 9-15 part, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 3-6 part, Herba Peperomiae Dindygulensis 8-13 part, Radix Luffae 3-5 part, Rhizoma Acori Graminei 1-3 part, Radix Et Rhizoma Rhei 5-10 part, Herba Pteridis Multifidae 5-10 part, Fructus Citri Sarcodactylis 13-16 part, Radix Scutellariae 3-10 part, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 8-13 part, Herba Selaginellae Uncinatae 3-5 part, Herba Ixeritis Sonchifoliae 1-3 part, Cortex Magnoliae Officinalis 5-10 part, Caulis Bambusae In Taeniam 9-15 part, Fructus Piperis Longi 3-7 part.

Further, raw material composition and the parts by weight of making described Chinese medicine preparation are: 6 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 8 parts, Fructus Trichosanthis 3 parts, Herba Lobeliae Chinensis 15 parts, Herba stellariae mediae 5 parts, Herba Portulacae 3 parts, Herba Sarcandrae 5 parts, Herba Vernonia esculenta 12 parts, Herba Galii Teneri 16 parts, Radix Stephaniae Cepharanthae 3 parts, the Rhizoma Pinelliae 12 parts, Herba seu Radix Calanthes 12 parts, Rhizoma Drynariae 10 parts, Caulis Spatholobi 9 parts, Rhizoma Corydalis 15 parts, Herba Ecliptae 15 parts, Herba Andrographis 8 parts, Herba Hyperici Japonici 5 parts, Herba Patriniae 3 parts, Herba Galii Teneri 14 parts, Radix Isatidis 9 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 6 parts, Herba Peperomiae Dindygulensis 8 parts, Radix Luffae 5 parts, Rhizoma Acori Graminei 1 part, Radix Et Rhizoma Rhei 10 parts, Herba Pteridis Multifidae 5 parts, Fructus Citri Sarcodactylis 16 parts, Radix Scutellariae 10 parts, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 8 parts, Herba Selaginellae Uncinatae 5 parts, Herba Ixeritis Sonchifoliae 1 part, Cortex Magnoliae Officinalis 10 parts, Caulis Bambusae In Taeniam 15 parts, Fructus Piperis Longi 3 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine preparation are: 4 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 10 parts, Fructus Trichosanthis 4 parts, Herba Lobeliae Chinensis 13 parts, Herba stellariae mediae 6 parts, Herba Portulacae 4 parts, Herba Sarcandrae 8 parts, Herba Vernonia esculenta 20 parts, Herba Galii Teneri 10 parts, Radix Stephaniae Cepharanthae 8 parts, the Rhizoma Pinelliae 5 parts, Herba seu Radix Calanthes 17 parts, Rhizoma Drynariae 12 parts, Caulis Spatholobi 4 parts, Rhizoma Corydalis 20 parts, Herba Ecliptae 10 parts, Herba Andrographis 12 parts, Herba Hyperici Japonici 2 parts, Herba Patriniae 7 parts, Herba Galii Teneri 11 parts, Radix Isatidis 15 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 3 parts, Herba Peperomiae Dindygulensis 13 parts, Radix Luffae 3 parts, Rhizoma Acori Graminei 3 parts, Radix Et Rhizoma Rhei 5 parts, Herba Pteridis Multifidae 10 parts, Fructus Citri Sarcodactylis 13 parts, Radix Scutellariae 3 parts, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 13 parts, Herba Selaginellae Uncinatae 3 parts, Herba Ixeritis Sonchifoliae 3 parts, Cortex Magnoliae Officinalis 5 parts, Caulis Bambusae In Taeniam 9 parts, Fructus Piperis Longi 7 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine preparation are: 5 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 12 parts, Fructus Trichosanthis 3 parts, Herba Lobeliae Chinensis 12 parts, Herba stellariae mediae 9 parts, Herba Portulacae 4 parts, Herba Sarcandrae 7 parts, Herba Vernonia esculenta 13 parts, Herba Galii Teneri 11 parts, Radix Stephaniae Cepharanthae 4 parts, the Rhizoma Pinelliae 6 parts, Herba seu Radix Calanthes 13 parts, Rhizoma Drynariae 7 parts, Caulis Spatholobi 5 parts, Rhizoma Corydalis 18 parts, Herba Ecliptae 11 parts, Herba Andrographis 9 parts, Herba Hyperici Japonici 4 parts, Herba Patriniae 6 parts, Herba Galii Teneri 12 parts, Radix Isatidis 13 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 4 parts, Herba Peperomiae Dindygulensis 9 parts, Radix Luffae 4 parts, Rhizoma Acori Graminei 2 parts, Radix Et Rhizoma Rhei 6 parts, Herba Pteridis Multifidae 6 parts, Fructus Citri Sarcodactylis 14 parts, Radix Scutellariae 5 parts, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 10 parts, Herba Selaginellae Uncinatae 4 parts, Herba Ixeritis Sonchifoliae 2 parts, Cortex Magnoliae Officinalis 6 parts, Caulis Bambusae In Taeniam 10 parts, Fructus Piperis Longi 5 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine preparation are: 4 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 11 parts, Fructus Trichosanthis 4 parts, Herba Lobeliae Chinensis 14 parts, Herba stellariae mediae 8 parts, Herba Portulacae 3 parts, Herba Sarcandrae 6 parts, Herba Vernonia esculenta 17 parts, Herba Galii Teneri 15 parts, Radix Stephaniae Cepharanthae 7 parts, the Rhizoma Pinelliae 11 parts, Herba seu Radix Calanthes 16 parts, Rhizoma Drynariae 8 parts, Caulis Spatholobi 8 parts, Rhizoma Corydalis 16 parts, Herba Ecliptae 14 parts, Herba Andrographis 11 parts, Herba Hyperici Japonici 3 parts, Herba Patriniae 5 parts, Herba Galii Teneri 13 parts, Radix Isatidis 14 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 5 parts, Herba Peperomiae Dindygulensis 12 parts, Radix Luffae 3 parts, Rhizoma Acori Graminei 1 part, Radix Et Rhizoma Rhei 10 parts, Herba Pteridis Multifidae 9 parts, Fructus Citri Sarcodactylis 13 parts, Radix Scutellariae 7 parts, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 11 parts, Herba Selaginellae Uncinatae 3 parts, Herba Ixeritis Sonchifoliae 1 part, Cortex Magnoliae Officinalis 10 parts, Caulis Bambusae In Taeniam 12 parts, Fructus Piperis Longi 6 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine preparation are: 6 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 9 parts, Fructus Trichosanthis 5 parts, Herba Lobeliae Chinensis 12 parts, Herba stellariae mediae 7 parts, Herba Portulacae 5 parts, Herba Sarcandrae 9 parts, Herba Vernonia esculenta 15 parts, Herba Galii Teneri 12 parts, Radix Stephaniae Cepharanthae 5 parts, the Rhizoma Pinelliae 9 parts, Herba seu Radix Calanthes 15 parts, Rhizoma Drynariae 9 parts, Caulis Spatholobi 7 parts, Rhizoma Corydalis 19 parts, Herba Ecliptae 13 parts, Herba Andrographis 10 parts, Herba Hyperici Japonici 4 parts, Herba Patriniae 4 parts, Herba Galii Teneri 11 parts, Radix Isatidis 11 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 5 parts, Herba Peperomiae Dindygulensis 10 parts, Radix Luffae 5 parts, Rhizoma Acori Graminei 3 parts, Radix Et Rhizoma Rhei 8 parts, Herba Pteridis Multifidae 8 parts, Fructus Citri Sarcodactylis 14 parts, Radix Scutellariae 9 parts, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 12 parts, Herba Selaginellae Uncinatae 5 parts, Herba Ixeritis Sonchifoliae 3 parts, Cortex Magnoliae Officinalis 8 parts, Caulis Bambusae In Taeniam 13 parts, Fructus Piperis Longi 3 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine preparation are: 3 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 8 parts, Fructus Trichosanthis 5 parts, Herba Lobeliae Chinensis 15 parts, Herba stellariae mediae 7 parts, Herba Portulacae 2 parts, Herba Sarcandrae 4 parts, Herba Vernonia esculenta 19 parts, Herba Galii Teneri 14 parts, Radix Stephaniae Cepharanthae 6 parts, the Rhizoma Pinelliae 7 parts, Herba seu Radix Calanthes 14 parts, Rhizoma Drynariae 9 parts, Caulis Spatholobi 6 parts, Rhizoma Corydalis 17 parts, Herba Ecliptae 13 parts, Herba Andrographis 10 parts, Herba Hyperici Japonici 4 parts, Herba Patriniae 4 parts, Herba Galii Teneri 11 parts, Radix Isatidis 11 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 5 parts, Herba Peperomiae Dindygulensis 10 parts, Radix Luffae 5 parts, Rhizoma Acori Graminei 3 parts, Radix Et Rhizoma Rhei 8 parts, Herba Pteridis Multifidae 8 parts, Fructus Citri Sarcodactylis 14 parts, Radix Scutellariae 4 parts, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 9 parts, Herba Selaginellae Uncinatae 5 parts, Herba Ixeritis Sonchifoliae 3 parts, Cortex Magnoliae Officinalis 8 parts, Caulis Bambusae In Taeniam 14 parts, Fructus Piperis Longi 4 parts.

Further, described Chinese medicine preparation is prepared according to following method:

(1) each medical material of components by weight percent in the arbitrary described Chinese medicine preparation of claim 3-8 is got, add in the ethanol of 8-12 times amount and soak 1.5-2.5 hour, heating extraction 2 times, each 1.5-2 hour, gets supernatant, merge extractive liquid, 120 orders filter, then are the ultrafiltration post ultrafiltration of 8000-12000 through the molecular weight that dams, the extractum of 1.3-1.4 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, stand for standby use;

(2) medicinal residues that ethanol extraction in step (1) is crossed are put into 10-12 times of water gaging, then put into extraction pot heated and boiled 1.5-2 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use;

(3) 2 filtrates in step (2) be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2-3h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state;

(4) the pastel decompression recycling ethanol concentrated for step (1) paste that obtains and step (3) obtained to be concentrated into liquor strength be 0.65-0.7g crude drug/mL, after sucking filtration, the 1.1-1.2 when relative density of filtrate is about 20 DEG C; Centrifugal under the rotating speed of 3000r/min; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(5) pulverized by dry extract obtained for step (4), after adding suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule; Or the dry extract that step (4) is obtained dry, pulverize, and makes powder; Or dry extract obtained for step (4) is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or dry extract obtained for step (4) is pulverized and adds suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet.

The invention still further relates to the application of a kind of described Chinese medicine preparation in treatment acute appendicitis medicine.

The Chinese medicine preparation for the treatment of acute appendicitis provided by the present invention, it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:

Radix Glycyrrhizae, nature and flavor: sweet, flat, there is effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, be used for the treatment of lack of appetite, weakness of the spleen and stomach, stomachache loose stool, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity and strong.

Herba Hedyotidis Diffusae: bitter in the mouth, sweet, cold in nature, enters the heart, liver, spleen, large intestine channel, has heat-clearing and toxic substances removing, the effect of promoting diuresis to eliminate damp pathogen, for dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, the cards such as cancerous protuberance, often utilize Herba Hedyotidis Diffusae anticancer, and it has certain radiation resistance.

Fructus Trichosanthis, sweet, micro-hardship, cold.Return lung, stomach, large intestine channel.Function cures mainly: clearing away heat and eliminating phlegm, and relieving stuffiness of the chest by dispersing aggregation of pathogens moisturizes laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation.

Herba Lobeliae Chinensis: base is former: be the whole herb with root of Campanulaceae Herba Lobeliae Chinensis.Chemical analysis: herb is containing alkaloid, flavonoid glycoside, Saponin, aminoacid.Antabac, lobelanine, lobelanidine, isolobelanine etc. are mainly in alkaloid.Rhizome, containing lobelinin, is a kind of levan.Nature and flavor: sweet are flat.Function cures mainly: diuretic, detumescence, and removing toxic substances, subcutaneous ulcer of harnessing the Yellow River, edema, tympanites, has loose bowels, dysentery, snakebite, furuncle, toxic swelling, eczema, and tinea disease, osteopatia sprain swells and ache.For extensive abdominal edema, face foot edema, carbuncle furuncle, snake bite and insect sting, advanced schistosomiasis ascites.

Herba stellariae mediae: sweet in the mouth, acid, cool in nature.Heat-clearing and toxic substances removing, blood-activating analgetic, lactogenic.For enteritis, dysentery, hepatitis, appendicitis, postnatal blood stasis is suffered from abdominal pain, uterine contraction pain, toothache, early whitening of hair, agalactia, mastitis, traumatic injury, sore swollen toxin." Bencao Tujing " carries: " wipe tooth a surname dew, dry work is not useful.”

Herba Portulacae inducing diuresis to remove edema, reduces blood pressure.Herba Portulacae contains a large amount of potassium salt, has good inducing diuresis to remove edema effect; Potassium ion also can directly act in blood vessel wall, and blood vessel wall is expanded, and stops ductus arteriosus wall to thicken, thus plays the effect reduced blood pressure.Medicinal function is heat-clearing and toxic substances removing, cooling blood for hemostasis.Because it contains abundant norepinephrine, pancreas islet gland excreting insulin can be promoted, regulate human body carbohydrate metabolism process, reduce blood sugar concentration, keep blood glucose constant, so have certain therapeutical effect to diabetes.In addition, it is also called the unsaturated fatty acid of 3-W containing one, can suppress the generation of cholesterol and triglyceride, have protective effect to cardiovascular.Compendium of Material Medica: " loose blood detumescence, sharp intestinal habitual abortion, detoxifies treating stranguria, sweating due to debility after managing property.”

Herba Sarcandrae: be the Herb of golden chestnut orchid Herba Pileae Scriptae Sarcandraglabra (Thunb.) Nakai, nature and flavor slightly warm in nature, bitter in the mouth, pungent.Function cures mainly: anti-inflammation, dispelling wind and removing obstruction in the collateral, blood circulation promoting and dispersing pathogen accumulation.For pneumonia, appendicitis, cellulitis, rheumatic arthralgia, injury from falling down, tumor.

Herba Vernonia esculenta: sweet in the mouth, puckery, cool in nature; Return Liver Channel.Heat-clearing and toxic substances removing, promoting tissue regeneration and ulcer healing.For appendicitis, furuncle, burn and scald." Medicinal Plants in Yunnan register " carries: " for appendicitis, furuncle.Leaf: treatment burn and scald." " Luchuan book on Chinese herbal medicine " year: " removing heat from blood, removing toxic substances, antiinflammatory, granulation promoting.Control pyretic toxicity, burn, pruritus, macule.”

Herba Galii Teneri: bitter in the mouth, pungent, cold in nature; Return lung, liver, kidney channel.Heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, reducing swelling and alleviating pain.For swollen ulcer drug, mastitis, appendicitis, edema, cold, fever, dysentery, urinary tract infection, hematuria, gingival hemorrhage, knife injury is hemorrhage." medical herbs handbook " carries: " heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Control carbuncle, appendicitis, closely for for cancer.”

Radix Stephaniae Cepharanthae: acrid in the mouth, hardship, cold in nature; Attach to the lung and stomach meridians.Heat-clearing and toxic substances removing, cooling blood for hemostasis, dissipating blood stasis for subsidence of swelling.For acute hepatitis, bacillary dysentery, acute appendicitis, stomachache, internal hemorrhage, traumatic injury, venom; Mumps is controlled in external, lymphadenitis, neurodermatitis." TCD identification handbook " carries: " heat-clearing and toxic substances removing, pain relieving.Control acute hepatitis, pernicious malaria, acute appendicitis, acute bacillary dysentery, venom, acute gastroenteritis, stomachache and other inflammation.”

The Rhizoma Pinelliae: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.

Herba seu Radix Calanthes, pungent, micro-hardship, is slightly cold, and enters liver, spleen channel.Function cures mainly: heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain.Main scrofula infections; Carbuncle; Laryngopharynx swelling and pain; Hemorrhoid; Rheumatic arthralgia; Traumatic injury.

Rhizoma Drynariae, nature and flavor: bitter, warm in nature, there is effect of invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation and stopping pain, be used for the treatment of that waist kneecap is ached, rheumatic arthralgia, foot and knee flaccidity, chronic diarrhea of suffering from a deficiency of the kidney, traumatic injury sprain and contusion, tinnitus, toothache, bone injury, appendicitis, alopecia areata, clavus and chronic diarrhea etc. of suffering from a deficiency of the kidney.

Caulis Spatholobi: bitter in the mouth, micro-sweet, warm in nature; Return liver, the heart, kidney channel.Relaxing muscles and tendons to promote blood circulation, nourishing blood for regulating menstruation.Cure mainly rheumatic arthralgia, numb hand and foot, quadriplegia, menoxenia, blockage of menstruation, dysmenorrhea, amenorrhea, leukopenia.

Rhizoma Corydalis, bitter in the mouth, pungent, warm in nature; Return liver, the heart, stomach warp; Benefaction is wandered away, and can rise and can fall, have promoting blood circulation to remove blood stasis, effect of promoting the circulation of QI to relieve pain.Cure mainly obstruction of qi in the chest and cardialgia, the side of body rib, all pains of gastral cavity abdomen, headache, lumbago, colicky, bones and muscles pain, dysmenorrhea, amenorrhea, puerperal, the stasis of blood was suffered from abdominal pain, traumatic injury.

Herba Ecliptae, sweet in the mouth, acid, cool in nature, return liver, kidney channel, liver and kidney tonifying; Cooling blood for hemostasis.Main deficiency of the liver and kindey; Have a dizzy spell; Early whitening of beard and hair; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Dysentery; Collapse; Leak; Traumatic hemorrhage.

Herba Andrographis: bitter in the mouth, cold in nature, GUIXIN, lung, large intestine, urinary bladder channel, have heat-clearing and toxic substances removing, removing heat from blood, and detumescence, effect of dampness, cures mainly cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, pertussis chronic cough, dysentery, the puckery pain of pyretic stranguria, carbuncle skin infection, the cards such as venom.

Herba Hyperici Japonici, sweet, micro-hardship, cool, clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, eliminating stasis to stop pain.For hepatitis, early stage liver cirrhosis, appendicitis, eye conjunctivitis, tonsillitis; Furuncle toxic swelling is controlled in external, herpes zoster, venom, traumatic injury.

Herba Patriniae, pungent, bitter, cool, return stomach, large intestine, Liver Channel, heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung abscess and sore and toxic, the stagnant caused breast abdomen pain of the excess-heat stasis of blood, the diseases such as the stagnant stomachache of the stasis of blood in puerperal.

Herba Galii Teneri, pungent, bitter, cool, heat-clearing and toxic substances removing, inducing diuresis to remove edema.Flu, gingival hemorrhage, acute and chronic appendicitis, urinary system infection, edema, dysmenorrhea, metrorrhagia, leucorrhea, cancer, leukemia; External controls mastitis from the beginning of, carbuncle furuncle and phyma poison, traumatic injury.

Radix Isatidis: heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving.Cortex Mori: meridian distribution of property and flavor: cold; Sweet; Return lung meridian.Function cures mainly: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For dyspnea and cough due to lung-heat, edema distension oliguria, appearance skin edema.

Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae): bitter in the mouth, cold in nature.Heat-clearing and toxic substances removing, benefiting stomach and stopping pain, dissipating blood stasis for subsidence of swelling.Control exogenous cough, pharyngalgia, aphtha of the mouth and tongue, vomiting and diarrhoea, dysentery, stomachache, swollen ulcer drug, traumatic injury.Guangzhou army " conventional Chinese herbal medicine handbook " carries: " heat-clearing and toxic substances removing, eliminating stasis to stop pain.Control stomach and duodenum to burst hemorrhoid pain, treating swelling and pain by traumatic injury, neuralgia, toothache, acute gastroenteritis, bacillary dysentery, upper respiratory tract infection, pharyngalgia.”

Herba Peperomiae Dindygulensis: acrid in the mouth, cool in nature; Return lung, spleen, liver, kidney channel.Heat-clearing and toxic substances removing, blood stasis-eliminating and stagnation-dissipating, inducing diuresis to remove edema.Cure mainly lung-heat cough with asthma, measles, sore, cancerous protuberance, burn and scald, traumatic injury, oedema due to nephritis, gastric cancer, esophageal carcinoma, hepatocarcinoma, breast carcinoma, pulmonary carcinoma." choosing of Simao, Yunnan Chinese herbal medicine " carries: " heat-clearing and toxic substances removing, detumescence dissipating blood stasis, pain relieving diuretic.Control traumatic injury, scald burn, carbuncle furuncle, oedema due to nephritis, pulmonary tuberculosis, asthma, tracheobronchitis, cough due to lung-heat.”

Radix Luffae: sweet in the mouth, property is put down.Heat-clearing and toxic substances removing, promoting blood circulation to remove obstruction in the collateral, detumescence.Control migraine, lumbago, mastitis, acute throat trouble swells and ache, discharging fresh blood stool, anal fistula." Chongqing medical herbs " carries: " the meridian dredging, promoting the circulation of blood are subsided a swelling swollen, stimulating milk secretion.”

Rhizoma Acori Graminei: pungent, bitter, temperature.GUIXIN, stomach warp.Effect with cure mainly: removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, the insane disease of coma, forgetful deafness.

Radix Et Rhizoma Rhei: be the rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.Nature and flavor with return through: bitter, cold..Function with cure mainly: purge heat poison, and removing mass is stagnant, clots absorbing blood.Control excess-heat constipation, delirium sends out holder, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spit blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, also urinates, carbuncle and ulcer toxic swelling, furuncle, burn.Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation., jaundice due to damp-heat not well for excess-heat constipation, stagnant stomachache, dysentery.

Herba Pteridis Multifidae: be herb or the root of Pteridaceae plant Herba Pteridis Multifidae.Nature and flavor with return through lightly seasoned micro-hardship, cold in nature.Function with cure mainly: clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, subduing swelling and detoxicating.Control icterohepatitis, enteritis, bacillary dysentery, stranguria with turbid discharge, leukorrhagia, spit blood, epistaxis, has blood in stool, hematuria, tonsillitis, parotitis, carbuncle sore tumefacting virus, eczema.

Fructus Citri Sarcodactylis: pungent, bitter, sour, temperature; Return liver, spleen, lung meridian." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " Fructus Citri Sarcodactylis disappears cold syndrome of the stomach expectorant, controls gastric qi pain, the only cold pain in face, and middle circulation of qi promoting for tonifying liver warming the stomach, anti-nausea." " book on Chinese herbal medicine is new again ": " control gas soothing liver-QI, stomach function regulating reduces phlegm, and removing mass controls dysphagia and regurgitation, eliminating mass abdominal mass scrofula." liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.Limettin contained by this product shrinks guinea-pig isolated trachea caused by histamine, has antagonism; Show there is certain antiallergic activity in the isolated ileum segments in guinea pigs of Ovum Gallus domesticus album sensitization and isolated tracheal test.This product ethanol extract has obvious inhibitory action to rat, rabbits infestines, and intravenous administration also has same inhibitory action to anesthetized cat, rabbit at body intestinal tube.Fructus Citri Sarcodactylis ethanol extract significantly can increase the coronary flow of guinea pig isolated heart and improve the hypoxia-bearing capability of mice; Protective effect is had to the myocardial ischemia that rat causes because of pituitrin.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are by the strong feature of broad-spectrum antibacterial action, are used in fungal culture miscellaneous bacteria and infect special severe, fine by Radix Scutellariae extracting solution effect." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: bitter in the mouth is so dampness; YIN-cold is so victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover.Bitter cold can except damp and hot, thus small intestinal profit and water from by, source is clearly then flowed also clean.The blood person of closing, excess-heat is at blood system, and instant heating human blood room, it is obstructed to make us amenorrhea, and damp and hot solution, then Ying Qi clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood then stays knot, and is that carbuncle stain is also rotten: acute scleritis person, also, removing heat from blood heat extraction, then spontaneous recovery also for fire of moxibustion blood trouble.Radix Scutellariae has antiallergic action and antiinflammatory action: the anaphylaxis contractile response that baicalin contained by Radix Scutellariae and baicalin can obviously suppress sensitized guinea pig rat small intestine in vitro and isolated tracheal to produce antigen, to passive general allergy and the Cavia porcellus passivity skin allergic reaction of Cavia porcellus and mice, baicalin and baicalin also have inhibitory action.Radix Scutellariae has refrigeration function, and most test proves, the active ingredient baicaligenin of Radix Scutellariae has refrigeration function.Radix Scutellariae has Detoxication, and baicalin has obvious Detoxication, and this may be that baicalin decomposites glucuronic acid due under the effect of glucuronidase, and caused by being combined with multiple poisonous substance.The LD50 that baicalin 10 milligrams can improve strychnine reaches 2.5 times, and the hepatic glycogen content of carbon tetrachloride poisoning mice is increased.

Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.): bitter in the mouth, cold in nature.For the herb of Labiatae bugle Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.).There is heat-clearing and toxic substances removing, effect of removing heat from blood suppressing the hyperactive liver.For upper respiratory tract infection, tonsillitis, pharyngitis, bronchitis, pneumonia, lung abscess, gastroenteritis, hepatitis, appendicitis, mastitis, acute conjunctivitis, hypertension; Traumatic injury is controlled in external, traumatic hemorrhage, carbuncle furuncle infections, burn and scald, venom.

Herba Selaginellae Uncinatae: lightly seasoned, property is put down.For the herb of Spikemoss plant CUIYUNCAO.There is clearing away heat-damp and promoting diuresis, removing toxic substances, repercussive, effect of hemostasis.For jaundice, dysentery, edema, rheumatic arthralgia, cough is spitted blood, retropharyngeal abscess, anal fistula, knife injury, scalds.

Herba Ixeritis Sonchifoliae: base is former: be the herb of feverfew Herba Ixeritis Sonchifoliae.Chemical analysis: herb contains flavonoid, phenoloid, organic acid, coumarin lactone, aminoacid, plant sterol etc., and containing adenine riboside.Nature and flavor: bitter in the mouth; Pungent; Property.Function cures mainly: alleviating pain and detumescence; Heat-clearing and toxic substances removing.Main headache; Toothache; Stomachache; Postoperative pain; Traumatic pain; Appendicitis; Intestinal is scorching; Pulmonary abscess; Laryngopharynx swelling and pain; Carbuncle furuncle.

Cortex Magnoliae Officinalis: base is former: be bark or the root bark of Magnoliacea plant Cortex Magnoliae Officinalis or magnolia officinalis rehd.et wils.var.biloba rehd.et wils..Nature and flavor: bitter, pungent, temperature.Gui Jing: return spleen, stomach, lung, large intestine channel.Function cures mainly: dampness expectorant, and the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.

Caulis Bambusae In Taeniam, for Phallaceae fungus bamboo claim, the sporophore of short-skirted veiled lady, sweet, micro-hardship, cool in nature, boosting qi and nourishing yin; Nourishing the lung to arrest cough; Clearing away heat-damp and promoting diuresis.Main deficiency of the lung heat syndrome cough; Laryngitis; Dysentery; Leucorrhea; Hypertension; Hyperlipemia.

Fructus Piperis Longi, acrid in the mouth, warm in nature, return stomach, spleen, kidney channel, there is cold relieving, invigorate blood circulation, warming YANG, blood stasis dispelling, the effect such as to regulate the flow of vital energy, be mainly used in the diseases such as treatment angina pectoris, stomachache, diarrhoea.

In Chinese medicine preparation of the present invention, Herba Hedyotidis Diffusae, Herba stellariae mediae, Herba Vernonia esculenta, Herba Sarcandrae, Herba Pteridis Multifidae, Radix Et Rhizoma Rhei, Radix Scutellariae heat-clearing and toxic substances removing, anti-inflammation is monarch drug; With Herba Galii Teneri, Herba Andrographis, Herba Patriniae, Herba Lobeliae Chinensis, Herba Galii Teneri, Radix Stephaniae Cepharanthae, Radix Isatidis, Herba Peperomiae Dindygulensis, Radix Luffae, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Herba Hyperici Japonici, Herba Portulacae, the Rhizoma Pinelliae, Herba seu Radix Calanthes, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Herba Selaginellae Uncinatae, Cortex Magnoliae Officinalis, Herba Ixeritis Sonchifoliae clearing away heat-damp and promoting diuresis, reducing swelling and alleviating pain is ministerial drug; Coordinative role is played for the medicine of assisting a ruler in governing a country with Fructus Trichosanthis, Rhizoma Drynariae, Caulis Spatholobi, Rhizoma Corydalis, Herba Ecliptae, Rhizoma Acori Graminei, Fructus Citri Sarcodactylis, Caulis Bambusae In Taeniam, Fructus Piperis Longi, heat clearing away eliminating stagnation, invigorating the spleen and replenishing QI, promoting the circulation of QI to relieve pain, clearing away heart-fire for tranquillization thus strengthen monarch drug and ministerial drug function, and restrict the toxic and side effects of other drug.Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, for making medicine.The same use of all medicines, drug effect is gentle, and the efficacy of a drug is lasting, thus reaches effect of heat-clearing and toxic substances removing, vital energy regualting and blood circulation-promoting, logical diarrhoea heat, cures acute appendicitis.

Selected by the Chinese medicine preparation for the treatment of acute appendicitis of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine theory, there is effect of heat-clearing and toxic substances removing, anti-inflammation, inducing diuresis to remove edema, detumescence and apocenosis, easy to use, good absorbing effect, without bad and toxic and side effects, through clinical verification, can blood circulation promoting and dispersing pathogen accumulation and middle appetizing, activating QI pain relieving, improve body internal and external environment, thus treatment or alleviate the various symptoms of acute appendicitis, be suitable for acute appendicitis clinical treatment and nursing is applied.

Detailed description of the invention

For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, technical scheme of the present invention is clearly and completely described.Obviously, described embodiment is a part of the present invention, instead of whole embodiments.Based on described embodiments of the invention, the every other embodiment that those of ordinary skill in the art obtain under without the need to the prerequisite of creative work, all belongs to the scope of protection of the invention.

Embodiment 1:

A kind of Chinese medicine preparation for the treatment of acute appendicitis of the present invention, get following traditional Chinese medicine raw medicine: 6 grams, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 8 grams, Fructus Trichosanthis 3 grams, Herba Lobeliae Chinensis 15 grams, Herba stellariae mediae 5 grams, Herba Portulacae 3 grams, Herba Sarcandrae 5 grams, Herba Vernonia esculenta 12 grams, Herba Galii Teneri 16 grams, Radix Stephaniae Cepharanthae 3 grams, the Rhizoma Pinelliae 12 grams, Herba seu Radix Calanthes 12 grams, Rhizoma Drynariae 10 grams, Caulis Spatholobi 9 grams, Rhizoma Corydalis 15 grams, Herba Ecliptae 15 grams, Herba Andrographis 8 grams, Herba Hyperici Japonici 5 grams, Herba Patriniae 3 grams, Herba Galii Teneri 14 grams, Radix Isatidis 9 grams, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 6 grams, Herba Peperomiae Dindygulensis 8 grams, Radix Luffae 5 grams, Rhizoma Acori Graminei 1 gram, Radix Et Rhizoma Rhei 10 grams, Herba Pteridis Multifidae 5 grams, Fructus Citri Sarcodactylis 16 grams, Radix Scutellariae 10 grams, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 8 grams, Herba Selaginellae Uncinatae 5 grams, Herba Ixeritis Sonchifoliae 1 gram, Cortex Magnoliae Officinalis 10 grams, Caulis Bambusae In Taeniam 15 grams, Fructus Piperis Longi 3 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) each medical material of components by weight percent described in described Chinese medicine preparation is got, add in the ethanol of 12 times amount and soak 2.5 hours, heating extraction 2 times, each 2 hours, gets supernatant, merge extractive liquid, 120 orders filter, then are the ultrafiltration post ultrafiltration of 8000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.3 extractum, heating is concentrated into paste, stand for standby use;

(2) medicinal residues that ethanol extraction in step (1) is crossed are put into 12 times of water gagings, then put into extraction pot heated and boiled 1.5-2 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use;

(3) 2 filtrates in step (2) be combined, by filtered through gauze, add 60% ethanol in residue, 60 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state;

(4) the pastel decompression recycling ethanol concentrated for step (1) paste that obtains and step (3) obtained to be concentrated into liquor strength be 0.65-0.7g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.2; Centrifugal under the rotating speed of 3000r/min; At 60 DEG C of spraying dry, obtain dry extract;

(5) pulverized by dry extract obtained for step (4), after adding suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule.

Embodiment 2:

A kind of Chinese medicine preparation for the treatment of acute appendicitis of the present invention, get following traditional Chinese medicine raw medicine: 4 grams, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 10 grams, Fructus Trichosanthis 4 grams, Herba Lobeliae Chinensis 13 grams, Herba stellariae mediae 6 grams, Herba Portulacae 4 grams, Herba Sarcandrae 8 grams, Herba Vernonia esculenta 20 grams, Herba Galii Teneri 10 grams, Radix Stephaniae Cepharanthae 8 grams, the Rhizoma Pinelliae 5 grams, Herba seu Radix Calanthes 17 grams, Rhizoma Drynariae 12 grams, Caulis Spatholobi 4 grams, Rhizoma Corydalis 20 grams, Herba Ecliptae 10 grams, Herba Andrographis 12 grams, Herba Hyperici Japonici 2 grams, Herba Patriniae 7 grams, Herba Galii Teneri 11 grams, Radix Isatidis 15 grams, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 3 grams, Herba Peperomiae Dindygulensis 13 grams, Radix Luffae 3 grams, Rhizoma Acori Graminei 3 grams, Radix Et Rhizoma Rhei 5 grams, Herba Pteridis Multifidae 10 grams, Fructus Citri Sarcodactylis 13 grams, Radix Scutellariae 3 grams, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 13 grams, Herba Selaginellae Uncinatae 3 grams, Herba Ixeritis Sonchifoliae 3 grams, Cortex Magnoliae Officinalis 5 grams, Caulis Bambusae In Taeniam 9 grams, Fructus Piperis Longi 7 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) each medical material of components by weight percent described in described Chinese medicine preparation is got, add in the ethanol of 8 times amount and soak 1.5 hours, heating extraction 2 times, each 1.5 hours, gets supernatant, merge extractive liquid, 120 orders filter, then are the ultrafiltration post ultrafiltration of 8000-12000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.4 extractum, heating is concentrated into paste, stand for standby use;

(2) medicinal residues that ethanol extraction in step (1) is crossed are put into 10 times of water gagings, then put into extraction pot heated and boiled 1.5-2 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use;

(3) 2 filtrates in step (2) be combined, by filtered through gauze, add 50% ethanol in residue, 70 DEG C are continued lixiviate 3h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state;

(4) the pastel decompression recycling ethanol concentrated for step (1) paste that obtains and step (3) obtained to be concentrated into liquor strength be 0.65-0.7g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.1; Centrifugal under the rotating speed of 3000r/min; At 80 DEG C of spraying dry, obtain dry extract;

(5) dry extract that step (4) is obtained be dry, pulverize, make powder.

Embodiment 3:

A kind of Chinese medicine preparation for the treatment of acute appendicitis of the present invention, get following traditional Chinese medicine raw medicine: 5 grams, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 12 grams, Fructus Trichosanthis 3 grams, Herba Lobeliae Chinensis 12 grams, Herba stellariae mediae 9 grams, Herba Portulacae 4 grams, Herba Sarcandrae 7 grams, Herba Vernonia esculenta 13 grams, Herba Galii Teneri 11 grams, Radix Stephaniae Cepharanthae 4 grams, the Rhizoma Pinelliae 6 grams, Herba seu Radix Calanthes 13 grams, Rhizoma Drynariae 7 grams, Caulis Spatholobi 5 grams, Rhizoma Corydalis 18 grams, Herba Ecliptae 11 grams, Herba Andrographis 9 grams, Herba Hyperici Japonici 4 grams, Herba Patriniae 6 grams, Herba Galii Teneri 12 grams, Radix Isatidis 13 grams, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 4 grams, Herba Peperomiae Dindygulensis 9 grams, Radix Luffae 4 grams, Rhizoma Acori Graminei 2 grams, Radix Et Rhizoma Rhei 6 grams, Herba Pteridis Multifidae 6 grams, Fructus Citri Sarcodactylis 14 grams, Radix Scutellariae 5 grams, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 10 grams, Herba Selaginellae Uncinatae 4 grams, Herba Ixeritis Sonchifoliae 2 grams, Cortex Magnoliae Officinalis 6 grams, Caulis Bambusae In Taeniam 10 grams, Fructus Piperis Longi 5 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) each medical material of components by weight percent described in described Chinese medicine preparation is got, add in the ethanol of 10 times amount and soak 2.0 hours, heating extraction 2 times, each 1.5 hours, gets supernatant, merge extractive liquid, 120 orders filter, then are the ultrafiltration post ultrafiltration of 10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.3 extractum, heating is concentrated into paste, stand for standby use;

(2) medicinal residues that ethanol extraction in step (1) is crossed are put into 10 times of water gagings, then put into extraction pot heated and boiled 2 hours, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use;

(3) 2 filtrates in step (2) be combined, by filtered through gauze, add 55% ethanol in residue, 60 DEG C are continued lixiviate 2.5h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state;

(4) the pastel decompression recycling ethanol concentrated for step (1) paste that obtains and step (3) obtained to be concentrated into liquor strength be 0.65-0.7g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.1; Centrifugal under the rotating speed of 3000r/min; At 70 DEG C of spraying dry, obtain dry extract;

(5) dry extract obtained for step (4) is pulverized, add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet.

Embodiment 4:

A kind of Chinese medicine preparation for the treatment of acute appendicitis of the present invention, get following traditional Chinese medicine raw medicine: 4 grams, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 11 grams, Fructus Trichosanthis 4 grams, Herba Lobeliae Chinensis 14 grams, Herba stellariae mediae 8 grams, Herba Portulacae 3 grams, Herba Sarcandrae 6 grams, Herba Vernonia esculenta 17 grams, Herba Galii Teneri 15 grams, Radix Stephaniae Cepharanthae 7 grams, the Rhizoma Pinelliae 11 grams, Herba seu Radix Calanthes 16 grams, Rhizoma Drynariae 8 grams, Caulis Spatholobi 8 grams, Rhizoma Corydalis 16 grams, Herba Ecliptae 14 grams, Herba Andrographis 11 grams, Herba Hyperici Japonici 3 grams, Herba Patriniae 5 grams, Herba Galii Teneri 13 grams, Radix Isatidis 14 grams, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 5 grams, Herba Peperomiae Dindygulensis 12 grams, Radix Luffae 3 grams, Rhizoma Acori Graminei 1 gram, Radix Et Rhizoma Rhei 10 grams, Herba Pteridis Multifidae 9 grams, Fructus Citri Sarcodactylis 13 grams, Radix Scutellariae 7 grams, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 11 grams, Herba Selaginellae Uncinatae 3 grams, Herba Ixeritis Sonchifoliae 1 gram, Cortex Magnoliae Officinalis 10 grams, Caulis Bambusae In Taeniam 12 grams, Fructus Piperis Longi 6 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) each medical material of components by weight percent described in described Chinese medicine preparation is got, add in the ethanol of 11 times amount and soak 2.2 hours, heating extraction 2 times, each 1.5-2 hour, gets supernatant, merge extractive liquid, 120 orders filter, then are the ultrafiltration post ultrafiltration of 9000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.3 extractum, heating is concentrated into paste, stand for standby use;

(2) medicinal residues that ethanol extraction in step (1) is crossed are put into 12 times of water gagings, then put into extraction pot heated and boiled 2 hours, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use;

(3) 2 filtrates in step (2) be combined, by filtered through gauze, add 50-60% ethanol in residue, 70 DEG C are continued lixiviate 3h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state;

(4) the pastel decompression recycling ethanol concentrated for step (1) paste that obtains and step (3) obtained to be concentrated into liquor strength be 0.65-0.7g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.1; Centrifugal under the rotating speed of 3000r/min; At 70 DEG C of spraying dry, obtain dry extract;

(5) dry extract obtained for step (4) is pulverized, add appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule.

Embodiment 5:

A kind of Chinese medicine preparation for the treatment of acute appendicitis of the present invention, get following traditional Chinese medicine raw medicine: 6 grams, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 9 grams, Fructus Trichosanthis 5 grams, Herba Lobeliae Chinensis 12 grams, Herba stellariae mediae 7 grams, Herba Portulacae 5 grams, Herba Sarcandrae 9 grams, Herba Vernonia esculenta 15 grams, Herba Galii Teneri 12 grams, Radix Stephaniae Cepharanthae 5 grams, the Rhizoma Pinelliae 9 grams, Herba seu Radix Calanthes 15 grams, Rhizoma Drynariae 9 grams, Caulis Spatholobi 7 grams, Rhizoma Corydalis 19 grams, Herba Ecliptae 13 grams, Herba Andrographis 10 grams, Herba Hyperici Japonici 4 grams, Herba Patriniae 4 grams, Herba Galii Teneri 11 grams, Radix Isatidis 11 grams, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 5 grams, Herba Peperomiae Dindygulensis 10 grams, Radix Luffae 5 grams, Rhizoma Acori Graminei 3 grams, Radix Et Rhizoma Rhei 8 grams, Herba Pteridis Multifidae 8 grams, Fructus Citri Sarcodactylis 14 grams, Radix Scutellariae 9 grams, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 12 grams, Herba Selaginellae Uncinatae 5 grams, Herba Ixeritis Sonchifoliae 3 grams, Cortex Magnoliae Officinalis 8 grams, Caulis Bambusae In Taeniam 13 grams, Fructus Piperis Longi 3 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) each medical material of components by weight percent described in described Chinese medicine preparation is got, add in the ethanol of 9 times amount and soak 2.5 hours, heating extraction 2 times, each 1.5 hours, gets supernatant, merge extractive liquid, 120 orders filter, then are the ultrafiltration post ultrafiltration of 12000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.4 extractum, heating is concentrated into paste, stand for standby use;

(2) medicinal residues that ethanol extraction in step (1) is crossed are put into 12 times of water gagings, then put into extraction pot heated and boiled 2 hours, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use;

(3) 2 filtrates in step (2) be combined, by filtered through gauze, add 60% ethanol in residue, 70 DEG C are continued lixiviate 3h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state;

(4) the pastel decompression recycling ethanol concentrated for step (1) paste that obtains and step (3) obtained to be concentrated into liquor strength be 0.65-0.7g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.2; Centrifugal under the rotating speed of 3000r/min; At 60 DEG C of spraying dry, obtain dry extract;

(5) pulverized by dry extract obtained for step (4), after adding suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule.

Embodiment 6:

A kind of Chinese medicine preparation for the treatment of acute appendicitis of the present invention, get following traditional Chinese medicine raw medicine: 3 grams, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 8 grams, Fructus Trichosanthis 5 grams, Herba Lobeliae Chinensis 15 grams, Herba stellariae mediae 7 grams, Herba Portulacae 2 grams, Herba Sarcandrae 4 grams, Herba Vernonia esculenta 19 grams, Herba Galii Teneri 14 grams, Radix Stephaniae Cepharanthae 6 grams, the Rhizoma Pinelliae 7 grams, Herba seu Radix Calanthes 14 grams, Rhizoma Drynariae 9 grams, Caulis Spatholobi 6 grams, Rhizoma Corydalis 17 grams, Herba Ecliptae 13 grams, Herba Andrographis 10 grams, Herba Hyperici Japonici 4 grams, Herba Patriniae 4 grams, Herba Galii Teneri 11 grams, Radix Isatidis 11 grams, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 5 grams, Herba Peperomiae Dindygulensis 10 grams, Radix Luffae 5 grams, Rhizoma Acori Graminei 3 grams, Radix Et Rhizoma Rhei 8 grams, Herba Pteridis Multifidae 8 grams, Fructus Citri Sarcodactylis 14 grams, Radix Scutellariae 4 grams, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 9 grams, Herba Selaginellae Uncinatae 5 grams, Herba Ixeritis Sonchifoliae 3 grams, Cortex Magnoliae Officinalis 8 grams, Caulis Bambusae In Taeniam 14 grams, Fructus Piperis Longi 4 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) each medical material of components by weight percent described in described Chinese medicine preparation is got, add in the ethanol of 12 times amount and soak 2.5 hours, heating extraction 2 times, each 1.5 hours, gets supernatant, merge extractive liquid, 120 orders filter, then are the ultrafiltration post ultrafiltration of 8000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.3 extractum, heating is concentrated into paste, stand for standby use;

(2) medicinal residues that ethanol extraction in step (1) is crossed are put into 12 times of water gagings, then put into extraction pot heated and boiled 1.5-2 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use;

(3) 2 filtrates in step (2) be combined, by filtered through gauze, add 55% ethanol in residue, 60 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state;

(4) the pastel decompression recycling ethanol concentrated for step (1) paste that obtains and step (3) obtained to be concentrated into liquor strength be 0.65-0.7g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.1; Centrifugal under the rotating speed of 3000r/min; At 60 DEG C of spraying dry, obtain dry extract;

(5) dry extract obtained for step (4) is pulverized, add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet.

Acute toxicity test:

Test material: Kunming mouse 40, body weight 22-25g.Medicine: the medicinal liquid that the granule that the embodiment of the present invention 5 obtains is made, containing 0.037mg/ml.

Method: LD50 calculates: adopt improvement karber's method, mice is divided into 4 groups at random, often organize 10, medicinal liquid agent adding distil water is dissolved, is made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 19.3,14.5,12.4 to dosage by crude drug amount, 9.3,7.1 (g.kg-1), in animal fasting (can't help water) after 24 hours, administration at twice in a day (interval half an hour), each 0.6ml, observes animal dead situation.

Result of the test: in LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18.6g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, to observation post administration 14 days, none was dead for mice, main organs no abnormality seen, also have no other obviously abnormal, within the 14th day, put to death and cut open inspection some animals, perusal main organs no abnormality seen.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18.6g/Kg.d.

Six months long term toxicity tests: weigh weekly once during administration, every day claims appetite, without dead or moribund animals, result mice hair color is bright and clean, and behavioral activity, glandular secretion, breathing, feces character are all normal.Pathologic finding is pointed out, to various internal organs without obvious drug-induced pathological change.

Clinical reasoning:

In order to verify the effect of Chinese medicine composition of the present invention, in May ,-2014 in October, 2012, Acute Appendicitis Patients 180 example is in hospital randomly drawed in outpatient service place, and patient is divided into two groups at random, treatment group 90 example, wherein male 42 example, women 48 example, 9 years old ~ 61 years old age, 24 years old mean age, the course of disease 1 month ~ 2 months, average 1 year.Matched group 90 example, wherein male 44 example, women 46 example, 13 years old ~ 56 years old age, 28 years old mean age, course of disease two weeks ~ 1 month, average two weeks.The course of disease, the degrees of symptoms of two groups of cases are basically identical, without significant difference, have comparability.

Diagnostic criteria is with reference to clinical manifestation:

(1) suffer from abdominal pain the typical acute appendicitis initial stage have middle upper abdomen or umbilicus week pain, after a few hours stomachache shift and be fixed on Right Lower Abdomen.When inflammation involves placenta percreta and parietal peritoneum, namely pain be fixed on Right Lower Abdomen, and namely former middle upper abdomen or pain around the navel alleviate or disappear.Therefore, without typical transitivity Right Lower Abdomen history of pain can not except acute appendicitis.

Simple appendicitis is often in paroxysmal or persistence distending pain with dull pain, and persistence severe pain often prompts for suppurative or gangrenous appendicitis.Lasting severe pain involves middle lower abdomen or both sides lower abdomen, is often the sign of vermiform appendix gangrene perforation.

(2) gastrointestinal symptom of gastrointestinal symptom simple appendicitis is not given prominence to.Nausea and vomiting may be had in early days due to reflexive stomach spasm.Pelvic cavity position appendicitis or vermiform appendix gangrene perforation can have defecation frequency to increase.

(3) heating generally only has low grade fever, and without shiver with cold, suppurative appendicitis is generally also no more than 38 DEG C.High overabundant heat sees vermiform appendix gangrene, perforation or Complicating Peritonitis.

(4) tenderness and rebound tenderness abdominal tenderness are the performances that parietal peritoneum is subject to inflammatory stimulus.Namely in right anterior superior iliac spine and umbilicus line, outer 1/3 intersection mcburney point is usually located at mcBurney point.Rebound tenderness also claims Blumberg to levy.Patient that is fat or retrocecally appendicitis, tenderness may be comparatively light, but have obvious rebound tenderness.

(5) namely tension of abdominal muscle vermiform appendix suppurates this sign, and during gangrene perforation Complicating Peritonitis, tension of abdominal muscle is particularly remarkable.But old or obese patient's abdominal muscle is more weak, must check simultaneously pleurosternal muscle is contrasted.

(6) dermal sensation allergy in early days, especially have when blocking in vermiform appendix chamber, Right Lower Abdomen dermal sensation allergic phenomena can be there is, scope is equivalent to 10th ~ 12 breast myelomere section innervation districts, be positioned at the trigonum that right crista iliaca peak, right pubic crest and umbilicus are formed, also claim Sherren triangle, it does not change because vermiform appendix position is different, as namely vermiform appendix gangrene perforation then disappears at the dermal sensation allergic phenomena of this trigonum.

Therapeutic Method:

Treatment group takes the tablet of the embodiment of the present invention 3, and sooner or later take at twice, each 2-3 sheet 10 days is 1 course for the treatment of, treats 1-3 the course for the treatment of altogether.

The oral cefalexin Tablet of matched group, cefathiamidine intramuscular injection :-secondary 0.5g ~ 1.0g, 4 times on the one, penicillin sodium intramuscular injection-secondary 0.5g ~ 1.0g, 4 times on the one 10 days is 1 course for the treatment of, treats 1-3 the course for the treatment of altogether.

Efficacy assessment standard:

(1) clinical recovery: clinical symptoms, sign disappear, follows up a case by regular visits to 3 months without recurrence.

(2) effective: symptom obviously alleviates.

(3) effective: symptom alleviates slightly.

(4) invalid: clinical symptoms, sign are without change.

Statistical procedures uses SPSS12.0 software to carry out statistical analysis, and ask that mean compares employing one factor analysis of variance for each group, group is asked and compared employing between two.Inspection.P<0.05 is that difference has significance.

Efficacy result:

Table 1 liang group patient clinical comparitive study (routine %)

Group

Number of cases

Clinical recovery

Effective

Effectively

Invalid

Effectively total

Treatment group

90

36(40％)

45(50％)

7(7.7％)

2(2.2％)

88(97.8％)

Matched group

90

4(4.4％)

27(30％)

11(12.2％)

48(53.3％)

42(46.7％)

Wherein, total effective rate=cure rate+obvious effective rate.Two groups are and occur untoward reaction.

Table 1 result shows: tablet total effective rate prepared by the embodiment of the present invention 3 is 97.8%; matched group total effective rate 46.7%; result shows; the clinical efficacy of Chinese medicine preparation in treatment acute appendicitis prepared by technical solution of the present invention is remarkable; and be better than the medicaments such as conventional cefalexin Tablet, be suitable for scale clinical practice.

Here is the model case of inventor's daily clinic contact:

Case 1:

Chen, man, 34 years old, people from South, Qingdao City.There is pain around umbilicus without obvious inducement in patient, companion feels sick, and pain moves to right lower abdomen gradually, fixedly moves, and conscious pain comparatively before increases the weight of, and with heating, is diagnosed as acute appendicitis.Take the granule of Chinese medicine preparation of the present invention, one day twice, each one bag, sooner or later one after each meal, within 10 days, be a course for the treatment of, after 1 course for the treatment of, the transference cures such as health is rehabilitation gradually, pain, continue to take 2 courses for the treatment of, and physical recovery is healthy.Follow up a case by regular visits to and do not recur so far.

Case 2:

River, female, 46 years old, people from Lixia District, Jinan City.Patient's Right Lower Abdomen paroxysmal distending pain, with Nausea and vomiting, without heating, cough, symptom of diarrhea.Be diagnosed as left hip acute appendicitis.Take the tablet of the embodiment of the present invention 6, one day twice, each two panels, one after each meal, 10 days is a course for the treatment of sooner or later, and after using two courses for the treatment of, pain disappears, and health is fully recovered, and does not recur again.

Case 3:

Grandson, man, 60 years old, people from Laiyang, Yantai.Patient is admitted to hospital because of the lower abdominal pain heat that occurs together.Stomachache, in persistence, occasionally has paroxysmal to increase the weight of, does not radiate to other positions.Soon having a little fear of cold after being ill, there is heating in the later stage, and companion feels sick, but without vomiting.Oliguria with yellow urine, takes the capsule of the embodiment of the present invention 4, one day twice, each two, sooner or later one after each meal, and after 2 courses for the treatment of, symptom obviously alleviates, and after continuing to take 2 courses for the treatment of, physical recovery is normal, and activity freely.Follow up a case by regular visits to and do not recur so far.

Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.

Claims (10)

1. treat a Chinese medicine preparation for acute appendicitis, it is characterized in that: the crude drug of described Chinese medicine preparation is made up of Radix Glycyrrhizae, Herba Hedyotidis Diffusae, Fructus Trichosanthis, Herba Lobeliae Chinensis, Herba stellariae mediae, Herba Portulacae, Herba Sarcandrae, Herba Vernonia esculenta, Herba Galii Teneri, Radix Stephaniae Cepharanthae, the Rhizoma Pinelliae, Herba seu Radix Calanthes, Rhizoma Drynariae, Caulis Spatholobi, Rhizoma Corydalis, Herba Ecliptae, Herba Andrographis, Herba Hyperici Japonici, Herba Patriniae, Herba Galii Teneri, Radix Isatidis, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Herba Peperomiae Dindygulensis, Radix Luffae, Rhizoma Acori Graminei, Radix Et Rhizoma Rhei, Herba Pteridis Multifidae, Fructus Citri Sarcodactylis, Radix Scutellariae, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Herba Selaginellae Uncinatae, Herba Ixeritis Sonchifoliae, Cortex Magnoliae Officinalis, Caulis Bambusae In Taeniam, Fructus Piperis Longi etc.

2. the Chinese medicine preparation for the treatment of acute appendicitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation are: Radix Glycyrrhizae 3-6 part, Herba Hedyotidis Diffusae 8-13 part, Fructus Trichosanthis 3-5 part, Herba Lobeliae Chinensis 11-15 part, Herba stellariae mediae 5-10 part, Herba Portulacae 2-5 part, Herba Sarcandrae 4-9 part, Herba Vernonia esculenta 12-20 part, Herba Galii Teneri 10-16 part, Radix Stephaniae Cepharanthae 3-8 part, Rhizoma Pinelliae 5-12 part, Herba seu Radix Calanthes 12-17 part, Rhizoma Drynariae 7-12 part, Caulis Spatholobi 4-9 part, Rhizoma Corydalis 15-20 part, Herba Ecliptae 10-15 part, Herba Andrographis 8-12 part, Herba Hyperici Japonici 2-5 part, Herba Patriniae 3-7 part, Herba Galii Teneri 11-14 part, Radix Isatidis 9-15 part, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 3-6 part, Herba Peperomiae Dindygulensis 8-13 part, Radix Luffae 3-5 part, Rhizoma Acori Graminei 1-3 part, Radix Et Rhizoma Rhei 5-10 part, Herba Pteridis Multifidae 5-10 part, Fructus Citri Sarcodactylis 13-16 part, Radix Scutellariae 3-10 part, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 8-13 part, Herba Selaginellae Uncinatae 3-5 part, Herba Ixeritis Sonchifoliae 1-3 part, Cortex Magnoliae Officinalis 5-10 part, Caulis Bambusae In Taeniam 9-15 part, Fructus Piperis Longi 3-7 part.

3. the Chinese medicine preparation for the treatment of acute appendicitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation are: 6 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 8 parts, Fructus Trichosanthis 3 parts, Herba Lobeliae Chinensis 15 parts, Herba stellariae mediae 5 parts, Herba Portulacae 3 parts, Herba Sarcandrae 5 parts, Herba Vernonia esculenta 12 parts, Herba Galii Teneri 16 parts, Radix Stephaniae Cepharanthae 3 parts, the Rhizoma Pinelliae 12 parts, Herba seu Radix Calanthes 12 parts, Rhizoma Drynariae 10 parts, Caulis Spatholobi 9 parts, Rhizoma Corydalis 15 parts, Herba Ecliptae 15 parts, Herba Andrographis 8 parts, Herba Hyperici Japonici 5 parts, Herba Patriniae 3 parts, Herba Galii Teneri 14 parts, Radix Isatidis 9 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 6 parts, Herba Peperomiae Dindygulensis 8 parts, Radix Luffae 5 parts, Rhizoma Acori Graminei 1 part, Radix Et Rhizoma Rhei 10 parts, Herba Pteridis Multifidae 5 parts, Fructus Citri Sarcodactylis 16 parts, Radix Scutellariae 10 parts, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 8 parts, Herba Selaginellae Uncinatae 5 parts, Herba Ixeritis Sonchifoliae 1 part, Cortex Magnoliae Officinalis 10 parts, Caulis Bambusae In Taeniam 15 parts, Fructus Piperis Longi 3 parts.

4. the Chinese medicine preparation for the treatment of acute appendicitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation are: 4 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 10 parts, Fructus Trichosanthis 4 parts, Herba Lobeliae Chinensis 13 parts, Herba stellariae mediae 6 parts, Herba Portulacae 4 parts, Herba Sarcandrae 8 parts, Herba Vernonia esculenta 20 parts, Herba Galii Teneri 10 parts, Radix Stephaniae Cepharanthae 8 parts, the Rhizoma Pinelliae 5 parts, Herba seu Radix Calanthes 17 parts, Rhizoma Drynariae 12 parts, Caulis Spatholobi 4 parts, Rhizoma Corydalis 20 parts, Herba Ecliptae 10 parts, Herba Andrographis 12 parts, Herba Hyperici Japonici 2 parts, Herba Patriniae 7 parts, Herba Galii Teneri 11 parts, Radix Isatidis 15 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 3 parts, Herba Peperomiae Dindygulensis 13 parts, Radix Luffae 3 parts, Rhizoma Acori Graminei 3 parts, Radix Et Rhizoma Rhei 5 parts, Herba Pteridis Multifidae 10 parts, Fructus Citri Sarcodactylis 13 parts, Radix Scutellariae 3 parts, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 13 parts, Herba Selaginellae Uncinatae 3 parts, Herba Ixeritis Sonchifoliae 3 parts, Cortex Magnoliae Officinalis 5 parts, Caulis Bambusae In Taeniam 9 parts, Fructus Piperis Longi 7 parts.

5. the Chinese medicine preparation for the treatment of acute appendicitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation are: 5 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 12 parts, Fructus Trichosanthis 3 parts, Herba Lobeliae Chinensis 12 parts, Herba stellariae mediae 9 parts, Herba Portulacae 4 parts, Herba Sarcandrae 7 parts, Herba Vernonia esculenta 13 parts, Herba Galii Teneri 11 parts, Radix Stephaniae Cepharanthae 4 parts, the Rhizoma Pinelliae 6 parts, Herba seu Radix Calanthes 13 parts, Rhizoma Drynariae 7 parts, Caulis Spatholobi 5 parts, Rhizoma Corydalis 18 parts, Herba Ecliptae 11 parts, Herba Andrographis 9 parts, Herba Hyperici Japonici 4 parts, Herba Patriniae 6 parts, Herba Galii Teneri 12 parts, Radix Isatidis 13 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 4 parts, Herba Peperomiae Dindygulensis 9 parts, Radix Luffae 4 parts, Rhizoma Acori Graminei 2 parts, Radix Et Rhizoma Rhei 6 parts, Herba Pteridis Multifidae 6 parts, Fructus Citri Sarcodactylis 14 parts, Radix Scutellariae 5 parts, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 10 parts, Herba Selaginellae Uncinatae 4 parts, Herba Ixeritis Sonchifoliae 2 parts, Cortex Magnoliae Officinalis 6 parts, Caulis Bambusae In Taeniam 10 parts, Fructus Piperis Longi 5 parts.

6. the Chinese medicine preparation for the treatment of acute appendicitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation are: 4 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 11 parts, Fructus Trichosanthis 4 parts, Herba Lobeliae Chinensis 14 parts, Herba stellariae mediae 8 parts, Herba Portulacae 3 parts, Herba Sarcandrae 6 parts, Herba Vernonia esculenta 17 parts, Herba Galii Teneri 15 parts, Radix Stephaniae Cepharanthae 7 parts, the Rhizoma Pinelliae 11 parts, Herba seu Radix Calanthes 16 parts, Rhizoma Drynariae 8 parts, Caulis Spatholobi 8 parts, Rhizoma Corydalis 16 parts, Herba Ecliptae 14 parts, Herba Andrographis 11 parts, Herba Hyperici Japonici 3 parts, Herba Patriniae 5 parts, Herba Galii Teneri 13 parts, Radix Isatidis 14 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 5 parts, Herba Peperomiae Dindygulensis 12 parts, Radix Luffae 3 parts, Rhizoma Acori Graminei 1 part, Radix Et Rhizoma Rhei 10 parts, Herba Pteridis Multifidae 9 parts, Fructus Citri Sarcodactylis 13 parts, Radix Scutellariae 7 parts, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 11 parts, Herba Selaginellae Uncinatae 3 parts, Herba Ixeritis Sonchifoliae 1 part, Cortex Magnoliae Officinalis 10 parts, Caulis Bambusae In Taeniam 12 parts, Fructus Piperis Longi 6 parts.

7. the Chinese medicine preparation for the treatment of acute appendicitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation are: 6 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 9 parts, Fructus Trichosanthis 5 parts, Herba Lobeliae Chinensis 12 parts, Herba stellariae mediae 7 parts, Herba Portulacae 5 parts, Herba Sarcandrae 9 parts, Herba Vernonia esculenta 15 parts, Herba Galii Teneri 12 parts, Radix Stephaniae Cepharanthae 5 parts, the Rhizoma Pinelliae 9 parts, Herba seu Radix Calanthes 15 parts, Rhizoma Drynariae 9 parts, Caulis Spatholobi 7 parts, Rhizoma Corydalis 19 parts, Herba Ecliptae 13 parts, Herba Andrographis 10 parts, Herba Hyperici Japonici 4 parts, Herba Patriniae 4 parts, Herba Galii Teneri 11 parts, Radix Isatidis 11 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 5 parts, Herba Peperomiae Dindygulensis 10 parts, Radix Luffae 5 parts, Rhizoma Acori Graminei 3 parts, Radix Et Rhizoma Rhei 8 parts, Herba Pteridis Multifidae 8 parts, Fructus Citri Sarcodactylis 14 parts, Radix Scutellariae 9 parts, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 12 parts, Herba Selaginellae Uncinatae 5 parts, Herba Ixeritis Sonchifoliae 3 parts, Cortex Magnoliae Officinalis 8 parts, Caulis Bambusae In Taeniam 13 parts, Fructus Piperis Longi 3 parts.

8. the Chinese medicine preparation for the treatment of acute appendicitis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation are: 3 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 8 parts, Fructus Trichosanthis 5 parts, Herba Lobeliae Chinensis 15 parts, Herba stellariae mediae 7 parts, Herba Portulacae 2 parts, Herba Sarcandrae 4 parts, Herba Vernonia esculenta 19 parts, Herba Galii Teneri 14 parts, Radix Stephaniae Cepharanthae 6 parts, the Rhizoma Pinelliae 7 parts, Herba seu Radix Calanthes 14 parts, Rhizoma Drynariae 9 parts, Caulis Spatholobi 6 parts, Rhizoma Corydalis 17 parts, Herba Ecliptae 13 parts, Herba Andrographis 10 parts, Herba Hyperici Japonici 4 parts, Herba Patriniae 4 parts, Herba Galii Teneri 11 parts, Radix Isatidis 11 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 5 parts, Herba Peperomiae Dindygulensis 10 parts, Radix Luffae 5 parts, Rhizoma Acori Graminei 3 parts, Radix Et Rhizoma Rhei 8 parts, Herba Pteridis Multifidae 8 parts, Fructus Citri Sarcodactylis 14 parts, Radix Scutellariae 4 parts, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 9 parts, Herba Selaginellae Uncinatae 5 parts, Herba Ixeritis Sonchifoliae 3 parts, Cortex Magnoliae Officinalis 8 parts, Caulis Bambusae In Taeniam 14 parts, Fructus Piperis Longi 4 parts.

9., according to the Chinese medicine preparation of the arbitrary described treatment acute appendicitis of claim 3-8, it is characterized in that: described Chinese medicine preparation is prepared according to following method:

(1) each medical material of components by weight percent in the arbitrary described Chinese medicine preparation of claim 3-8 is got, add in the ethanol of 8-12 times amount and soak 1.5-2.5 hour, heating extraction 2 times, each 1.5-2 hour, gets supernatant, merge extractive liquid, 120 orders filter, then are the ultrafiltration post ultrafiltration of 8000-12000 through the molecular weight that dams, the extractum of 1.3-1.4 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, stand for standby use;

(2) medicinal residues that ethanol extraction in step (1) is crossed are put into 10-12 times of water gaging, then put into extraction pot heated and boiled 1.5-2 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use;

(3) 2 filtrates in step (2) be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2-3h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into pasty state;

(4) the pastel decompression recycling ethanol concentrated for step (1) paste that obtains and step (3) obtained to be concentrated into liquor strength be 0.65-0.7g crude drug/mL, after sucking filtration, the 1.1-1.2 when relative density of filtrate is about 20 DEG C; Centrifugal under the rotating speed of 3000r/min; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(5) pulverized by dry extract obtained for step (4), after adding suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule; Or the dry extract that step (4) is obtained dry, pulverize, and makes powder; Or dry extract obtained for step (4) is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or dry extract obtained for step (4) is pulverized and adds suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet.

10. the application of Chinese medicine preparation in treatment acute appendicitis medicine of the treatment acute appendicitis as described in as arbitrary in claim 1-9.