CN113368003A

CN113368003A - Composition with overnight muscle repairing effect and preparation method and application thereof

Info

Publication number: CN113368003A
Application number: CN202110712383.5A
Authority: CN
Inventors: 孔秋婵; 陈庆生; 夏高辉
Original assignee: Guangzhou Huanya Cosmetic Science and Technology Co Ltd
Current assignee: Guangzhou Huanya Cosmetic Science and Technology Co Ltd
Priority date: 2021-06-25
Filing date: 2021-06-25
Publication date: 2021-09-10

Abstract

The invention relates to the technical field of cosmetics, and discloses a composition with a night muscle repairing effect, a preparation method and an application thereof, wherein the composition comprises the following components: hydroxyethyl piperazine ethanesulfonic acid, vitamin A and its derivatives, resorcinol derivatives, Crispum Anemone stem cells, vegetable oils and fats, cacao seed water extract, hydrolyzed yeast protein and ceramide. The composition can be used for preparing cosmetics such as essence, lotion, cream or facial mask. The composition disclosed by the invention has multiple effects of moisturizing, smoothing and refining, brightening skin color, resisting aging and fading, repairing damage and the like by compounding a plurality of components and realizing synergistic interaction, and has a wide application prospect and a huge market value.

Description

Composition with overnight muscle repairing effect and preparation method and application thereof

Technical Field

The invention relates to the technical field of cosmetics, and particularly relates to a composition with a night muscle repairing effect, and a preparation method and application thereof.

Background

In modern society, people have less and less sleep time and have more and more late sleep time due to problems of living habits, entertainment modes, working pressure, psychological states and the like. Irregular daily activities can affect human health, cause alopecia, obesity, decreased immunity, and hypomnesis, and also cause many skin problems. A series of conditions of dry skin, lack of water, rough skin, oil and acne, dark skin color, red blood, facial edema, dark eye circles, loose skin and the like appear after staying up all night, and the conditions are the appearance problems of 'staying up muscles', and can be called as 'staying up muscles'.

At present, the skin care products aiming at the skin staying up at night in the market are few in types, and some products only mainly moisturize and keep moisture, so that the real repairing effect cannot be achieved; or some plant extracts are used as active ingredients, but the specific efficacy is not clear; moreover, the effect of brightening and smoothing the skin is quickly achieved by using the acid brushing method, but the skin is more damaged to the muscles staying up all night originally, and the allergy risk is easy to occur. Therefore, the skin problem of people staying up all night is not really solved by the existing product aiming at the staying up night muscle.

The prior related art discloses a plant polar formula with the function of preventing and treating dark eye circles and edema around eyes caused by staying up all night, a preparation method and application thereof, wherein the plant formula comprises the following components in percentage by weight: 1-20% of pelargonium graveolens, 10-30% of evening primrose, 10-40% of leuconostoc asiatica bulbs, 10-40% of narcissus bulbs and 1-20% of Sambucus nigra flowers. Although the plant formula has certain tyrosinase inhibiting and edema removing capabilities, a series of problems of skin roughness, dryness, water shortage, skin looseness and the like caused by staying up to night on the skin cannot be solved.

The prior art discloses a composition and application thereof in preparing a product for nursing skin of a person staying up in the night, wherein the composition comprises adenosine, a Leucojum aestivum bulb extract, sodium hyaluronate, a skin conditioner A containing glycoprotein and amino acid, and a skin conditioner B containing glutamyl ethyl imidazole. Although the composition can play a certain role in moisturizing, restoring skin luster and promoting cell energy synthesis, the composition does not solve the problems of dark skin, looseness and the like caused by staying up all night.

Disclosure of Invention

The invention aims to provide a composition with the function of repairing muscles all over the night, so as to solve one or more technical problems in the prior art and provide at least one beneficial choice or creation condition.

The technical scheme adopted for solving the technical problems is as follows:

a composition with the effect of repairing muscles all night comprises the following components: hydroxyethyl piperazine ethanesulfonic acid, vitamin A and its derivatives, resorcinol derivatives, Crispum Anemone stem cells, vegetable oils and fats, cacao seed water extract, hydrolyzed yeast protein and ceramide.

The composition with the overnight muscle repairing effect is prepared by compounding the components, wherein:

the hydroxyethyl piperazine ethane sulfonic acid is a biological buffering agent, can maintain the structure of biological enzyme and the functions of active ingredients, also can soften cutin, mildly promote old cutin cells of the epidermal layer of skin to peel off, smooth and soften the skin, brighten the skin color, achieve the effect of whitening and promote the absorption of the active ingredients.

The vitamin A and the derivatives thereof can regulate the metabolism of epidermis and cuticle, solve the problem of pigment accumulation, simultaneously promote the synthesis of collagen cells, tighten and smooth the skin, dredge pores, have good curative effect on acne and have the function of diminishing inflammation.

The invention adopts callus with totipotent cells to culture in a bionic controllable sterile medium to obtain the hypecoum erectum stem cells (hypecoum erectum callus culture filtrate), which can stimulate cutin generation, promote epidermis regeneration, improve skin self-healing capability, improve skin luster and lighten pigmentation, reduce free radical damage and improve skin aging.

Blue light pollution from electronic devices can generate oxidative stress and increase skin photodamage, and excessive exposure of skin to blue light can delay barrier repair, causing premature aging and corresponding skin problems. The cocoa seed water extract is rich in molecular peptides, saccharides and polyphenols, and can maintain opsin content in keratinocyte under blue light pressure, reduce mitochondrial active oxygen and cell free oxygen caused by blue light pressure, improve shape and length of elastin fiber, reduce wrinkle and enhance skin elasticity.

Social jet lag is the dislocation of social time and human biological clock, which is influenced by modern life style, the imbalance of circadian rhythm and insufficient sleep become health hidden troubles, the skin aging is accelerated, the hydrolyzed yeast protein can regulate cell cycle (mitosis), the natural protective force of the skin is improved to resist UV damage and maintain the skin integrity in the daytime, the DNA repair and the skin regeneration process are promoted at night, and the anti-aging effect is achieved.

Ceramide can repair skin surface barrier, relieve dryness, rebuild skin brick wall structure, cooperates with degree of depth to repair. The ceramide 1 can intensively repair natural skin lipid membranes of the skin, strengthen the defense function of skin surface barrier, has good sealing property, and reduces water evaporation and loss; ceramide 2 improves the sebaceous membrane and simultaneously inhibits the secretion of active sebaceous glands, so that the water and oil of the skin are balanced, the self-protection function of the skin is enhanced, the red swelling and the percutaneous water loss are reduced, and the skin barrier is enhanced; the substance structure of the skin cuticle formed by the ceramide 3 is similar, and the ceramide 3 can quickly permeate into the skin to form a waterproof barrier to lock water and play a good role in moisturizing and repairing the skin; ceramide 4, also known as sphingolipid, can improve dry skin, desquamation, pachylosis, etc., improve skin water holding capacity, reduce wrinkle, enhance skin elasticity, and delay skin aging; ceramide 6 helps the stratum corneum of the skin to metabolize rapidly, making the skin smoother.

In the process of long-term production research, the inventor deeply excavates effective species of moisturizing, smoothing and smoothing, brightening skin color, resisting wrinkles and lightening lines and repairing damage in cosmetic components, and creatively discovers that when the components are combined together, the components can be mutually matched and synergized by utilizing the properties of the components, so that the finally obtained composition can achieve multiple effects of moisturizing, improving roughness, reducing darkness, increasing elasticity, lightening wrinkles, repairing damage and the like, and can improve skin state and enable skin to be healthier.

Preferably, the composition comprises the following components in parts by mass: 5-30 parts of hydroxyethyl piperazine ethanesulfonic acid, 1-20 parts of vitamin A and derivatives thereof, 1-10 parts of resorcinol derivatives, 0.1-10 parts of cumin dry cells, 5-50 parts of vegetable oil, 1-10 parts of cocoa seed water extract, 1-10 parts of hydrolyzed yeast protein and 1-10 parts of ceramide.

Preferably, the composition comprises the following components in parts by mass: 20-30 parts of hydroxyethyl piperazine ethanesulfonic acid, 5-10 parts of vitamin A and derivatives thereof, 5-10 parts of resorcinol derivatives, 1-10 parts of cumin dry cells, 30-50 parts of vegetable oil, 5-10 parts of cocoa seed water extract, 5-10 parts of hydrolyzed yeast protein and 1-10 parts of ceramide.

Preferably, the vitamin a and its derivatives include at least one of retinol, retinal, retinol acetate, retinol palmitate, hydroxy pinacolone retinoic acid ester and retinol retinoic acid ester, preferably one of retinol acetate, retinol palmitate or hydroxy pinacolone retinoic acid ester.

Preferably, the ceramide comprises at least one of ceramide 1, ceramide 1A, ceramide 2, ceramide 3, ceramide 4, and ceramide 6, preferably one of ceramide 2, ceramide 4, or ceramide 6.

Preferably, the resorcinol derivative comprises at least one of 4-butyl resorcinol, hexyl resorcinol, phenethyl resorcinol and dimethoxytolyl-4-propyl resorcinol, preferably phenethyl resorcinol.

The phenethyl resorcinol has excellent skin whitening effect, is one of tyrosinase inhibitors with the highest reported activity, can effectively inhibit the activity of B16V cells for synthesizing melanin, improves uneven skin color and reduces skin coloring caused by ultraviolet irradiation on the skin.

Preferably, the vegetable oil comprises at least one of squalane, jojoba seed oil, meadowfoam seed oil and macadamia nut oil, and is preferably squalane, and the squalane selected in the invention is derived from olive or sugarcane.

Squalane is a lipid close to sebum of a human body, has high moistening performance and moisture retention and strong affinity, can form a layer of natural barrier on the surface of skin, moistens but is not greasy, can inhibit peroxidation of skin lipid, promotes the proliferation of skin basal cells, and has obvious physiological effects on delaying skin aging, improving and eliminating chloasma.

The principle of the synergistic interaction of the components of the invention is as follows:

1. and (3) synergetic moisturizing: squalane is highly soluble in oil secreted by skin, a layer of breathable water-locking film is formed on the surface layer of the skin, ceramide has strong capacity of associating with water molecules, and maintains skin moisture by forming a net structure in the horny layer, so that the squalane and the skin moisture achieve a synergistic moisturizing effect.

2. And (3) synergistically tendering the skin: the hydroxyethyl piperazine ethane sulfonic acid softens cutin, very mildly promotes old waste cells to fall off, and the vitamin A and the derivatives thereof promote skin cells to fall off and simultaneously promote skin to generate new cells, thereby solving the problem of rough skin.

3. And (3) synergistic whitening: the hydroxyethyl piperazine ethane sulfonic acid, the vitamin A and the derivatives thereof can promote cutin exfoliation, improve skin glossiness, promote absorption of resorcinol derivatives, enhance whitening effect, accelerate skin renewal and skin decoloration by hydrolyzing yeast protein, and inhibit melanosome transfer by hypecol stem cells.

4. Synergistic protection against photodamage: the hydroxyethyl piperazine ethanesulfonic acid has absorptivity in UVA wave band and visible light wave band, can reduce ultraviolet ray and blue light damage of electronic products, and the cacao seed water extract and the hydrolyzed yeast protein can improve the light protection capability of skin, and synergistically resist the light damage.

5. Synergistic anti-aging: the cocoa seed water extract is helpful for improving the content of collagen I and fibrillin-1 in aging fibroblasts, hydrolyzing yeast protein to promote the expression of collagen III, and vitamin A and derivatives thereof can stimulate epidermal cell proliferation to thicken epidermal layer, and remarkably reduce wrinkles (main wrinkles and fine lines) from different layers under the synergistic effect of the three.

6. And (3) performing cooperative repair: ceramide and squalane can repair skin lipid membrane from external stimulation, vitamin A and its derivatives can accelerate cell proliferation, hypecol stem cells can weaken inflammatory reaction, promote vascular endothelial cell growth and accelerate healing, and cocoa seed water extract can promote proteoglycan synthesized by epidermis to jointly promote epidermis reconstruction.

A second object of the present invention is to provide a process for the preparation of the above composition, comprising the steps of: mixing the hydroxyethyl piperazine ethane sulfonic acid, vitamin A and derivatives thereof, resorcinol derivatives, hypecol stem cells, vegetable oil and fat, cacao seed water extract, hydrolyzed yeast protein and ceramide to obtain the composition.

The third purpose of the invention is to provide the application of the composition in cosmetics, wherein the cosmetics comprise any one of essence, emulsion, cream or facial mask.

The fourth purpose of the invention is to provide a mask, which comprises the following components: the composition, the emulsifier, the humectant, the thickener and the preservative are adopted; the composition accounts for 2-8% of the total mass of the mask.

Wherein the emulsifier is selected from EMT-10 (composition of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, polysorbate-60 and sorbitan isostearate), Edenor C18-65 MY (composition of stearic acid and palmitic acid), ARLACEL 165 (composition of glyceryl stearate and PEG-100 stearate), and MONTANOV 202 emulsifier (i.e. arachidyl alcohol/docosanol/arachidyl alcohol glucoside). The humectant adopts glycerol, 1, 3-propylene glycol and 1, 2-hexanediol. The thickener is SALACOS 5408(CETIOL PEEH-4), i.e. pentaerythritol tetra (ethyl hexanoate). The antiseptic is p-hydroxyacetophenone.

Compared with the prior art, the invention has the following beneficial effects:

the composition with the overnight muscle repairing effect has multiple effects of moisturizing, smoothing and smoothing, brightening skin color, resisting aging and lightening wrinkles, repairing damage and the like by compounding hydroxyethyl piperazine ethanesulfonic acid, vitamin A and derivatives thereof, resorcinol derivatives, anise stem cells, vegetable oil, cocoa seed water extracts, hydrolyzed yeast protein and ceramide, has a synergistic effect, and has wide application prospect and great market value.

Detailed Description

The concept and technical effects of the present invention will be clearly and completely described below in conjunction with the embodiments to fully understand the objects, features and effects of the present invention. It is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and those skilled in the art can obtain other embodiments without inventive effort based on the embodiments of the present invention, and all embodiments are within the protection scope of the present invention.

Some of the components used in the examples and comparative examples of the invention were sourced as follows:

hydroxyethyl piperazine ethane sulfonic acid was purchased from purer biomedicine, lazhou, vitamin a and its derivatives were purchased from BASF, warburgh chery biotechnology limited, companss chemical (north of hu), phenethyl resorcinol was purchased from Symrise de, henry stem cells were purchased from Biotech Marine, squalane was purchased from clariant, hydrolyzed yeast protein and cocoa water seed extract were purchased from ashland, ceramide was purchased from won and fighting mountain.

Example 1

A composition with an overnight muscle repairing effect comprises the following components in parts by mass: 30 parts of hydroxyethyl piperazine ethane sulfonic acid, 1 part of retinol palmitate, 10 parts of phenethyl resorcinol, 0.1 part of cumin stem cells, 50 parts of squalane, 10 parts of cocoa seed water extract, 10 parts of hydrolyzed yeast protein and 61 parts of ceramide.

The preparation method of the composition comprises the following steps: mixing the components, and stirring.

Example 2

A composition with an overnight muscle repairing effect comprises the following components in parts by mass: 5 parts of hydroxyethyl piperazine ethane sulfonic acid, 10 parts of hydroxy pinacolone retinoic acid ester, 1 part of phenethyl resorcinol, 10 parts of cumin stem cells, 5 parts of squalane, 10 parts of cocoa seed water extract, 10 parts of hydrolyzed yeast protein and 210 parts of ceramide.

The preparation method of the composition comprises the following steps: the components are mixed evenly to obtain the product.

Example 3

A composition with an overnight muscle repairing effect comprises the following components in parts by mass: 30 parts of hydroxyethyl piperazine ethane sulfonic acid, 20 parts of retinol acetate, 10 parts of phenethyl resorcinol, 10 parts of cumin stem cells, 20 parts of squalane, 1 part of cocoa seed water extract, 10 parts of hydrolyzed yeast protein and 410 parts of ceramide.

Example 4

A composition with an overnight muscle repairing effect comprises the following components in parts by mass: 20 parts of hydroxyethyl piperazine ethanesulfonic acid, 5 parts of retinol, 10 parts of 4-butyl resorcinol, 1 part of hypecoum japonicum stem cells, 50 parts of jojoba seed oil, 5 parts of cocoa seed water extract, 5 parts of hydrolyzed yeast protein and 11 parts of ceramide.

Example 5

A composition with an overnight muscle repairing effect comprises the following components in parts by mass: 30 parts of hydroxyethyl piperazine ethanesulfonic acid, 10 parts of retinal, 5 parts of hexyl resorcinol, 10 parts of cumin stem cells, 30 parts of meadowfoam seed oil, 10 parts of cocoa seed water extract, 10 parts of hydrolyzed yeast protein and 310 parts of ceramide.

Example 6

A composition with an overnight muscle repairing effect comprises the following components in parts by mass: 25 parts of hydroxyethyl piperazine ethane sulfonic acid, 10 parts of retinol retinoic acid ester, 5 parts of dimethoxy tolyl-4-propyl resorcinol, 5 parts of cumin dry cells, 40 parts of macadamia nut oil, 8 parts of cocoa seed water extract, 10 parts of hydrolyzed yeast protein and 1A 1 part of ceramide.

Example 7

A composition with an overnight muscle repairing effect comprises the following components in parts by mass: 30 parts of hydroxyethyl piperazine ethane sulfonic acid, 10 parts of retinol palmitate, 10 parts of hydroxy pinacolone retinoic acid ester, 5 parts of phenethyl resorcinol, 1 part of 4-butyl resorcinol, 5 parts of cumin stem cells, 10 parts of squalane, 10 parts of jojoba seed oil, 8 parts of cocoa seed water extract, 8 parts of hydrolyzed yeast protein, 23 parts of ceramide and 45 parts of ceramide.

Example 8

The composition with the effect of repairing muscles all over night comprises the following components in parts by weight: 3 parts of hydroxyethyl piperazine ethane sulfonic acid, 25 parts of retinol palmitate, 15 parts of phenethyl resorcinol, 15 parts of cumin stem cells, 4 parts of squalane, 13 parts of cocoa seed water extract, 12 parts of hydrolyzed yeast protein and 613 parts of ceramide.

Example 9

A composition with a night-out muscle repairing effect comprises, by weight, 3 parts of hydroxyethyl piperazine ethanesulfonic acid, 0.5 part of retinol palmitate, 0.5 part of phenethyl resorcinol, 0.05 part of sea fennel stem cells, 94.45 parts of squalane, 0.5 part of a cocoa seed water extract, 0.5 part of hydrolyzed yeast protein and 60.5 parts of ceramide.

Comparative example 1

Compared with the composition of the example 1, the hydroxyethyl piperazine ethane sulfonic acid is replaced by water in the composition components, and other components and the preparation method are the same as the example 1.

Comparative example 2

Compared with the composition of the example 1, the composition components are replaced by the retinol palmitate ester water, and other components and the preparation method are the same as the composition of the example 1.

Comparative example 3

Compared with the example 1, the phenylethyl resorcinol in the composition is replaced by water, and other components and the preparation method are the same as the example 1.

Comparative example 4

Compared with the composition of the example 1, the dry hypecoum anisum stem cells are replaced by water in the composition, and other components and the preparation method are the same as the example 1.

Comparative example 5

Compared with the composition of the example 1, the squalane in the composition components is replaced by water, and other components and the preparation method are the same as the example 1.

Comparative example 6

Compared with example 1, the water extract of cocoa seeds is replaced by water in the composition components, and other components and preparation methods are the same as example 1.

Comparative example 7

Compared with example 1, the hydrolyzed yeast protein in the composition is replaced by water, and other components and preparation method are the same as example 1

Comparative example 8

Compared with the example 1, the ceramide 6 in the composition components is replaced by water, and other components and the preparation method are the same as the example 1.

Comparative example 9

Compared with the composition of the example 1, the hydroxyethyl piperazine ethane sulfonic acid and the retinol palmitate are replaced by water in the composition, and other components and the preparation method are the same as the composition of the example 1.

Comparative example 10

Compared with the composition of the example 1, the hydroxyethyl piperazine ethane sulfonic acid and the phenethyl resorcinol in the composition components are replaced by water, and other components and the preparation method are the same as the example 1.

Comparative example 11

Compared with the composition of the example 1, the hydroxyethyl piperazine ethane sulfonic acid and the hypecoum japonicum stem cells are replaced by water in the composition, and other components and the preparation method are the same as the composition of the example 1.

Comparative example 12

Compared with the composition of the example 1, the hydroxyethyl piperazine ethane sulfonic acid and squalane are replaced by water in the composition, and other components and the preparation method are the same as the example 1.

Comparative example 13

Compared with the composition of example 1, the hydroxyethyl piperazine ethane sulfonic acid and the cocoa seed water extract are replaced by water in the composition components, and other components and the preparation method are the same as the composition of example 1.

Comparative example 14

Compared with the composition of the example 1, the hydroxyethyl piperazine ethane sulfonic acid and the hydrolyzed yeast protein are replaced by water in the composition, and other components and the preparation method are the same as the composition of the example 1.

Comparative example 15

Compared with the composition of the example 1, the hydroxyethyl piperazine ethane sulfonic acid and the ceramide 6 in the composition are replaced by water, and other components and the preparation method are the same as the composition of the example 1.

Comparative example 16

Compared with the composition of the example 1, the composition components are replaced by the retinol palmitate and the phenethyl resorcinol by water, and other components and the preparation method are the same as the example 1.

Comparative example 17

Compared with the composition of the example 1, the retinol palmitate and the hypecoum japonicum stem cells are replaced by water in the composition components, and other components and the preparation method are the same as the composition of the example 1.

Comparative example 18

Compared with the composition of the example 1, the components of the composition are replaced by the retinol palmitate and the squalane by water, and other components and the preparation method are the same as the example 1.

Comparative example 19

Compared with example 1, the composition components have retinol palmitate and cacao seed water extract replaced by water, and other components and preparation method are the same as example 1.

Comparative example 20

Compared with the composition of the example 1, the components of the composition are replaced by the retinol palmitate and the hydrolyzed yeast protein by water, and other components and the preparation method are the same as the composition of the example 1.

Comparative example 21

Compared with the composition of the example 1, the composition components replace the retinol palmitate and the ceramide 6 by water, and other components and the preparation method are the same as the composition of the example 1.

Comparative example 22

Compared with the example 1, the phenylethyl resorcinol and the hypecol stem cells are replaced by water in the components of the composition, and the other components and the preparation method are the same as the example 1.

Comparative example 23

Compared with the example 1, the composition has the components that the phenethyl resorcinol and the squalane are replaced by water, and other components and the preparation method are the same as the example 1.

Comparative example 24

Compared with the example 1, the phenylethyl resorcinol and the cocoa seed water extract are replaced by water in the composition components, and other components and the preparation method are the same as the example 1.

Comparative example 25

Compared with the example 1, the phenylethyl resorcinol and the hydrolyzed yeast protein in the composition are replaced by water, and other components and the preparation method are the same as the example 1.

Comparative example 26

Compared with the example 1, the phenylethyl resorcinol and the ceramide 6 in the composition components are replaced by water, and other components and the preparation method are the same as the example 1.

Comparative example 27

Compared with the composition of the example 1, the hypecoum japonicum stem cells and squalane are replaced by water in the components of the composition, and the other components and the preparation method are the same as the example 1.

Comparative example 28

Compared with the composition of the example 1, the sea fennel stem cells and the cocoa seed water extract are replaced by water in the composition components, and other components and the preparation method are the same as the example 1.

Comparative example 29

Compared with the composition of the example 1, the hypecoum japonicum stem cells and the hydrolyzed yeast protein are replaced by water in the components of the composition, and the other components and the preparation method are the same as the composition of the example 1.

Comparative example 30

Compared with the composition of the example 1, the hypecoum japonicum stem cells and the ceramide 6 are replaced by water in the components of the composition, and other components and the preparation method are the same as the example 1.

Comparative example 31

Compared with example 1, the composition has squalane and cacao seed water extract replaced by water, and other components and preparation method are the same as example 1.

Comparative example 32

Compared with the example 1, the composition has the components that squalane and hydrolyzed yeast protein are replaced by water, and other components and the preparation method are the same as the example 1.

Comparative example 33

Compared with the example 1, the squalane and the ceramide 6 in the composition components are replaced by water, and other components and the preparation method are the same as the example 1.

Comparative example 34

Compared with example 1, the water extract of cocoa seeds and hydrolyzed yeast protein are replaced by water in the composition components, and the other components and preparation method are the same as in example 1.

Comparative example 35

Compared with example 1, the water extract of cacao seed and ceramide 6 are replaced by water in the composition components, and other components and preparation method are the same as example 1.

Comparative example 36

Compared with the composition of the example 1, the composition has the components that ceramide 6 is replaced by phytosterol/octyl dodecanol lauroyl glutamate, and other components and the preparation method are the same as the composition of the example 1.

Application examples 1 to 9

The group of application examples (corresponding to serial numbers 1 to 9 respectively) provides a group of facial masks, the mass percentage of the specific formula of the facial masks is shown in table 1, wherein the compositions with the skin-care effect on night in the application examples 1 to 9 respectively correspond to the compositions with the skin-care effect on night prepared in the application examples 1 to 9.

TABLE 1

The preparation method of the mask of application examples 1 to 9 includes the following steps:

1) putting the component A into an emulsifying pot, and stirring at 80-85 ℃ until the component A is completely dissolved;

2) and putting the vegetable oil and the ceramide in the component B and the component D into an oil phase pot, stirring at 80-85 ℃ until the vegetable oil and the ceramide are completely dissolved, adding the vitamin A and the derivatives thereof and the resorcinol derivatives, and stirring until the vitamin A and the derivatives thereof are completely dissolved.

3) Pumping oil for emulsification, slowly pumping the product obtained in the step 2) into the emulsification pot in the step 1), homogenizing at a high speed for 15-20 min under the condition of 6000-9000 rpm, cooling to 60-65 ℃, adding the pre-dissolved C phase, and stirring until the pre-dissolved C phase is completely dissolved.

4) Cooling to below 40 deg.C, adding hydroxyethyl piperazine ethanesulfonic acid, hypecol stem cells, cacao seed water extract and hydrolyzed yeast protein in component D, stirring, dissolving, dispersing, inspecting physicochemical indexes such as color, pH, fragrance, and appearance, filtering with 200 mesh sieve, and discharging to obtain facial mask.

Comparative application examples 1 to 36

This set of comparative application examples provides a set of masks in which the compositions in comparative application examples 1 to 36 correspond to the compositions prepared using comparative examples 1 to 36, respectively, and the other components and preparation method were the same as in application example 1.

Efficacy test

The masks obtained in application examples 1 to 9 of the present invention and comparative application examples 1 to 36 were subjected to the following tests:

test example 1 measurement of moisturizing Effect

1.1 purpose of the experiment

Under the conditions that the temperature is 20 +/-2 ℃ and the humidity is 50 +/-10%, 150 subjects are selected, a blank control group is set, samples are smeared and tested on the two forearms of the subjects according to a double-blind principle, and the skin moisture content of the test samples is tested at T0, T30min and T2h, so that the moisturizing effect of the tested products on the skin surface layer is evaluated.

1.2 protocol

According to the standards (QB/T4256-; experiments were conducted in the guidelines for evaluation of moisturizing efficacy of cosmetic preparations.

1.3 evaluation index

Table 2 evaluation indexes: moisture value change rate of 2 hours

Dosage forms	Not reaching the standard	Reach the standard	Is excellent in
				Aqueous preparation	≤10％	10～30％	≥30％

1.4 test results

TABLE 3 moisture content variation value (%)

As can be seen from the data in Table 3, each of the application examples 1 to 9 and the comparative application examples 1 to 36 had a certain effect on the moisture content of the skin, and the effects of the application examples 1 to 7 were superior to those of the comparative application examples 1 to 36 and the application examples 8 to 9. Tests show that squalane and ceramide have the largest influence on the moisture content of the skin, and other components have smaller influence on the moisture content of the skin. Application examples 8 to 9 were poor in effect because the component ratios of the compositions were not within the limits of the present invention. The water replenishing and moisturizing agent disclosed by the invention has the advantages that the components are reasonably matched, so that the water replenishing and moisturizing agent has a good synergistic effect, is superior to other combination modes, and has a good water replenishing and moisturizing effect. Wherein the subject has stimulus feedback using application 8.

Test example 2 Brightness Effect test

2.1 purpose of the experiment

120 subjects are selected, half-face test is conducted randomly, samples are used once every night, and the face skin color brightness (L) is measured 20min after the faces of the subjects are cleaned at the temperature of 20 +/-2 ℃ and the humidity of 50 +/-10% at the time of D7 and D28, so that the whitening and brightening effects of the product on the skin are judged.

2.2 protocol

The reference method comprises the following steps: a cosmetic spot-removing whitening efficacy test method, version 2019.

2.3 criteria of determination

The L values are different, the larger the L value is, the more white the color is, and the smaller the L value is, the more black the color is.

2.4L value test results analysis

TABLE 4L value analysis results

As can be seen from the data in Table 4, the application examples 1-9 and part of the comparative application examples have certain effects on the brightness of the skin, wherein the effect of the application example 8 is optimal, but part of the subjects feedback stimulation (the proportion is 46%) in the test process, and the effects of the rest application examples 1-7 are better than those of the comparative application examples 1-36 and the application example 9. Tests show that the phenylethyl resorcinol has the greatest influence on the skin brightness, and the hydroxyethyl piperazine ethane sulfonic acid, the vitamin A and the derivatives thereof also have relatively obvious influence on the skin brightness, and part of comparative application examples in experiments also have adverse effect on the skin brightness. Application examples 8 to 9 were poor in effect or have irritation to the skin because the component ratios of the compositions were not within the range defined by the present invention. The skin care composition reasonably collocates a plurality of components, so that the skin care composition has a good synergistic effect, is superior to other combination modes, and has a good effect of improving the skin brightness.

Test example 3 measurement of repairing Effect

3.1 purpose of the experiment

Under the conditions that the temperature is 20 +/-2 ℃ and the humidity is 50 +/-10%, 150 subjects are selected, a blank control group is set, the use and the test are carried out on the left half face and the right half face of the subject according to a double-blind principle, and the test samples are subjected to a percutaneous water loss (TWEL) test on D7 and D28, so that the repair efficacy of the tested products on human barriers is evaluated.

3.2 protocol

Reference is made to the improvement of facial sensitive skin and the repair of skin barriers by bayer regel skin barrier repair agents.

3.3 criteria of determination

The TWEL values are significantly different, with higher TWEL values representing more transepidermal water loss per unit time and unit cross-sectional area, and lower TWELs representing less transepidermal water loss per unit time and unit cross-sectional area.

3.4TWEL test results analysis

TABLE 5 TWEL analysis results

Barrier repair tests were not performed due to stimulation feedback from pre-subject use application 8. The data in table 5 show that the application examples 1-7, application example 9 and comparative application examples all have certain effects on preventing skin moisture loss, namely certain repairing effects on skin barrier, wherein the effects of the application examples are better than those of the comparative application examples. Tests show that squalane, ceramide, hypecol stem cells, cocoa seed water extract and hydrolyzed yeast protein all have strong effects on repairing skin barriers. Application example 9 the effect was deteriorated since the component ratios of the compositions were not within the range defined by the present invention. The invention reasonably matches a plurality of components, has obvious synergistic effect and is superior to other combination modes.

Test example 4 measurement of light streak Effect

4.1 purpose of the experiment

The test article is measured and analyzed for the efficacy of the light streaks by instrumental analysis and subject evaluation.

4.2 protocol

And testing according to the instruction book for testing the effect of fading fine wrinkles in enterprises.

After the face of a subject is cleaned, wiping the face with a paper towel, statically sitting in a constant temperature and humidity room for 30.min, taking VISIA pictures, shooting left and right views, taking the skin of eyes for testing, detecting the skin elasticity value R5/R7, and recording data; the evaluator records the number and depth of wrinkles and comprehensively scores the degree of the wrinkles for the subject; the subjects filled out a skin information questionnaire.

Samples were dispensed and subjects were informed of notes.

Visit every week, after cleaning the face, wipe it dry with a paper towel, sit still in a constant temperature and humidity room for 30min, the subject fills out a questionnaire according to actual conditions, and the skin elasticity value is detected as R5/R7.

The test paper is used for the last return visit after the test is finished, the skin elasticity value R5/R7 is detected, and VISIA photographing record is carried out.

The blank control group was not used with product, but was also evaluated the same as the test group personnel.

4.3 criteria of determination

Table 6 evaluation indexes: rate of change over 28 days

4.4 analysis of Fine grain fading test results

Table 7 evaluation indexes: analysis result of Fine Trench count Change (%)

The data in table 7 show that the application examples 1 to 9 and the comparative application examples 1 to 36 have certain effects on fading the fine lines of the skin, wherein the effect of the application example 8 is optimal, but part of the subjects feedback stimulation (the proportion is 46%) in the test process, and the effects of the rest application examples 1 to 7 are better than those of the comparative application examples 1 to 36 and the application example 9. Tests show that the vitamin A and the derivatives thereof have good effect of reducing fine wrinkles, especially the vitamin A and the derivatives thereof have remarkable promoting effect when matched with hydrolyzed yeast protein and cocoa seed water extract, and other components also have certain effect of reducing fine wrinkles. Application example 9 the effect was deteriorated since the component ratios of the compositions were not within the range defined by the present invention. The invention reasonably matches a plurality of components, has obvious synergistic effect and is superior to other combination modes.

In conclusion, the components are reasonably compounded, so that the synergistic effect can be realized, the repairing and protecting effects of the components are exerted to the maximum extent, multiple skin nourishing effects of moisturizing, smoothing and smoothing, brightening skin color, resisting aging and fading, repairing damaged skin and the like are achieved, and the skin-care composition is prepared into cosmetics with the repairing and protecting effects of the skin staying up all night, such as a mask, essence and the like, so that the state of the skin staying up all night can be improved, and the skin staying up all night is healthier.

While the preferred embodiments of the present invention have been illustrated and described, it will be understood by those skilled in the art that the present invention is not limited to the details of the embodiments shown and described, but is capable of numerous equivalents and substitutions without departing from the spirit of the invention as set forth in the claims appended hereto.

Claims

1. A composition comprising the following components: hydroxyethyl piperazine ethanesulfonic acid, vitamin A and its derivatives, resorcinol derivatives, Crispum Anemone stem cells, vegetable oils and fats, cacao seed water extract, hydrolyzed yeast protein and ceramide.

2. The composition according to claim 1, characterized by comprising the following components in parts by mass: 5-30 parts of hydroxyethyl piperazine ethanesulfonic acid, 1-20 parts of vitamin A and derivatives thereof, 1-10 parts of resorcinol derivatives, 0.1-10 parts of cumin dry cells, 5-50 parts of vegetable oil, 1-10 parts of cocoa seed water extract, 1-10 parts of hydrolyzed yeast protein and 1-10 parts of ceramide.

3. The composition according to claim 2, characterized by comprising the following components in parts by mass: 20-30 parts of hydroxyethyl piperazine ethanesulfonic acid, 5-10 parts of vitamin A and derivatives thereof, 5-10 parts of resorcinol derivatives, 1-10 parts of cumin dry cells, 30-50 parts of vegetable oil, 5-10 parts of cocoa seed water extract, 5-10 parts of hydrolyzed yeast protein and 1-10 parts of ceramide.

4. A composition according to any one of claims 1 to 3, wherein said vitamin a and its derivatives comprise at least one of retinol, retinal, retinol acetate, retinol palmitate, hydroxy pinacolone retinoic acid ester and retinol retinoic acid ester.

5. The composition of any one of claims 1-3, wherein the ceramide comprises at least one of ceramide 1, ceramide 1A, ceramide 2, ceramide 3, ceramide 4, and ceramide 6.

6. The composition of any one of claims 1-3, wherein the resorcinol derivative comprises at least one of 4-butyl resorcinol, hexyl resorcinol, phenethyl resorcinol, and dimethoxytolyl-4-propyl resorcinol.

7. The composition of any one of claims 1 to 3, wherein the vegetable oil or fat comprises at least one of squalane, jojoba seed oil, meadowfoam seed oil and macadamia nut oil.

8. A process for the preparation of a composition according to any one of claims 1 to 7, characterized in that it comprises the following steps: mixing the hydroxyethyl piperazine ethane sulfonic acid, vitamin A and derivatives thereof, resorcinol derivatives, hypecol stem cells, vegetable oil and fat, cacao seed water extract, hydrolyzed yeast protein and ceramide to obtain the composition.

9. Use of a composition according to any one of claims 1 to 7 in cosmetics.

10. A facial mask characterized by comprising the composition according to any one of claims 1 to 7.