CN112514913A - Hydrogen peroxide disinfectant and preparation method thereof - Google Patents
Hydrogen peroxide disinfectant and preparation method thereof Download PDFInfo
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- CN112514913A CN112514913A CN201910880035.1A CN201910880035A CN112514913A CN 112514913 A CN112514913 A CN 112514913A CN 201910880035 A CN201910880035 A CN 201910880035A CN 112514913 A CN112514913 A CN 112514913A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/14—Ethers
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
- A01N59/20—Copper
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- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
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Abstract
The invention discloses a hydrogen peroxide disinfectant, which consists of the following components in percentage by weight: 0.3 to 0.6 percent of hydrogen peroxide; zinc ion/copper ion 0.01-0.05%; 0.05 to 0.50 percent of citric acid; 0.4 to 1.5 percent of penetrating agent; 0.1 to 1.0 percent of surfactant; 0.04 to 0.1 percent of stabilizer; the balance being purified water. The invention also discloses a preparation method of the hydrogen peroxide disinfectant. The hydrogen peroxide disinfectant can quickly kill the mycobacteria, and has good stability, catalyst resistance and strong anti-interference capability.
Description
Technical Field
The invention relates to the technical field of chemical disinfection of environmental object surfaces and air, in particular to a high-stability hydrogen peroxide disinfectant capable of quickly killing mycobacteria and a preparation method thereof.
Background
The chemical disinfectants used for disinfecting the environmental object surface at present mainly comprise quaternary ammonium salts, sodium hypochlorite and the like. Wherein, the quaternary ammonium salt disinfectant can only achieve low-level disinfection generally and can not kill mycobacteria; the sodium hypochlorite disinfectant can achieve high-level disinfection, but has strong corrosivity to a plurality of metals such as non-stainless steel metals due to the characteristics of strong alkali and strong oxidation, thereby limiting the application range of the sodium hypochlorite disinfectant.
Yet another widely used class of item surface disinfectants is the hydrogen peroxide disinfectant, where hydrogen peroxide is safe and residue-free, and the only products produced are water and oxygen, which is highly desirable. However, the low-concentration hydrogen peroxide disinfectant is generally not ideal in disinfection effect and poor in anti-interference capability, and cannot kill mycobacteria, in order to improve the disinfection effect, the concentration of hydrogen peroxide needs to be increased, and due to the existence of a catalyst in a general bacteria-contaminated environment, the concentration of hydrogen peroxide is high enough to meet the requirement of the disinfection capability, so that medical hydrogen peroxide generally contains 3% of hydrogen peroxide, and the hydrogen peroxide at the concentration has strong oxidizing property and certain potential danger in the safety aspect. In addition, in order to improve the sterilization effect of hydrogen peroxide, other synergistic substances, such as silver ions, etc., are generally added, which may cause instability of the hydrogen peroxide solution, thereby shortening the storage period of hydrogen peroxide and reducing the reliability thereof. And as a precious metal, silver is scarce in resources and does not meet the condition of large-scale use.
In view of the above disadvantages, there is a need in the art for a hydrogen peroxide disinfectant with good stability that can rapidly kill mycobacteria.
Disclosure of Invention
In view of the above-mentioned shortcomings in the prior art, it is desirable to provide a stable hydrogen peroxide disinfectant capable of killing mycobacteria rapidly, which has catalyst resistance and strong anti-interference capability. In addition, the present invention also seeks to provide a method of preparing the aforementioned hydrogen peroxide disinfectant.
According to the embodiment, the hydrogen peroxide disinfectant provided by the invention comprises the following components in percentage by weight:
0.3 to 0.6 percent of hydrogen peroxide;
zinc ion/copper ion 0.01-0.05%;
0.05 to 0.50 percent of citric acid;
0.4 to 1.5 percent of penetrating agent;
0.1 to 1.0 percent of surfactant;
0.04 to 0.1 percent of stabilizer;
the balance being purified water.
Further, in the above hydrogen peroxide disinfectant, the zinc ion/copper ion is a zinc salt/copper salt of a strong acid such as sulfuric acid, hydrochloric acid, or the like.
Further, in the hydrogen peroxide disinfectant, the penetrating agent is one or more of benzyl alcohol, ethylene glycol phenyl ether and other alcohols or ethers containing benzene rings.
Further, in the above hydrogen peroxide disinfectant, the surfactant is a zwitterionic surfactant, preferably an ammonium oxide surfactant or a sulfobetaine surfactant.
Further, in the hydrogen peroxide disinfectant, the stabilizer is an organic phosphate, preferably hydroxyethylidene diphosphonic acid (HEDP), diethylenetriamine pentamethylene phosphonic acid (DTPMP), 2-phosphonic acid butane-1, 2, 4-tricarboxylic acid (PBTCA), ethylene diamine tetra methylene phosphonic acid (EDTMP).
In the invention, the purified water is prepared according to the requirements of Chinese pharmacopoeia.
According to an embodiment, the present invention provides a method for preparing a hydrogen peroxide disinfectant, comprising the steps of: adding purified water into a proportioning container, sequentially adding purified water, stabilizer, surfactant, penetrant, citric acid, zinc ion/copper ion and hydrogen peroxide according to formula proportion, and stirring to obtain hydrogen peroxide disinfectant
Compared with the prior art, the following test examples prove that the invention has the following advantages:
the copper ions/zinc ions adopted in the invention are taken as the synergist, have certain inhibition effect on bacterial microorganisms, are taken as the non-competitive inhibitor of the catalyst, have strong inhibition effect on the catalyst, can protect hydrogen peroxide from being decomposed by the catalyst, and in addition, the experiment proves that the sterilization effect of the hydrogen peroxide is remarkably improved under the condition that the catalyst is inhibited. Silver ions are usually added into the existing hydrogen peroxide disinfectant to serve as a synergist, but silver serves as a precious metal, so that the resource is rare and the condition of large-scale use is not met.
The invention discovers that the anti-interference capability of the hydrogen peroxide disinfectant can be greatly improved and the sterilization capability of the hydrogen peroxide disinfectant can be enhanced after 0.4 to 1.5 percent of penetrating agent such as benzyl alcohol is added.
The disinfectant of the invention greatly reduces the common concentration of hydrogen peroxide and the potential danger without influencing the sterilization effect. The microorganism test shows that the hydrogen peroxide disinfectant with the concentration of 0.3-0.6% acts for 2min, and the killing log value of mycobacterium cheloni abscess subspecies is more than 4.00; acting for 1min to kill methicillin-resistant Staphylococcus aureus (MRSA) with log value of more than 5.00;
the hydrogen peroxide disinfectant can be used for air disinfection, and is sprayed for 10min with the dosage of 5mL/m3After the spraying is finished, the killing logarithm value of the staphylococcus albus is more than 4.00 after the spraying is performed for 30 minutes.
The hydrogen peroxide disinfectant is stored for 90 days at 37 ℃, the reduction rate is less than 3 percent, the stability is good, and the hydrogen peroxide disinfectant can be stably stored for more than 24 months at normal temperature.
Detailed Description
The invention will be further illustrated with reference to the following specific examples. These examples are to be construed as merely illustrative and not limitative of the remainder of the disclosure in any way whatsoever. After reading the description of the invention, one skilled in the art can make various changes and modifications to the invention, and such equivalent changes and modifications also fall into the scope of the invention defined by the claims.
Example 1
98.5kg of purified water, 0.08kg of hydroxyethylidene diphosphonic acid, 0.1kg of dodecyl dimethyl ammonium oxide, 0.5kg of benzyl alcohol, 0.2kg of citric acid, 0.03kg of copper sulfate and 0.55kg of hydrogen peroxide are sequentially added into a material mixing container and stirred uniformly to prepare the hydrogen peroxide disinfectant.
Example 2
98.5kg of purified water, 0.1kg of diethylenetriamine pentamethylenephosphonic acid, 0.2kg of dodecyl ethoxy betaine, 0.5kg of benzyl alcohol, 0.2kg of citric acid, 0.03kg of copper sulfate and 0.45kg of hydrogen peroxide are sequentially added into a batching container and stirred uniformly to prepare the hydrogen peroxide disinfectant.
Example 3
98.4kg of purified water, 0.05kg of hydroxyethylidene diphosphonic acid, 0.4kg of octadecyl ethoxy betaine, 0.5kg of ethylene glycol phenyl ether, 0.2kg of citric acid, 0.03kg of zinc sulfate and 0.37kg of hydrogen peroxide are sequentially added into a material mixing container and stirred uniformly to prepare the hydrogen peroxide disinfectant.
Test example 1 Sterilization test of Hydrogen peroxide disinfectant against Mycobacterium
The first check basis is as follows:
1. the neutralizer identification test and the quantitative sterilization test are carried out according to 2.1.1.5.5 and 2.1.1.7.4 disinfection technical specifications (2002 edition) of Ministry of health;
2. and (3) identification test of a neutralizer: 2.0min, the tested strain is mycobacterium cheloni abscess subspecies, the temperature of action is controlled by water bath to be 19-21 ℃, and the test is carried out for 3 times.
3. And (3) sterilization test: the samples prepared in examples 1 to 3 and containing 0.53%, 0.44% and 0.37% of hydrogen peroxide were applied to the samples, and the application temperature was controlled in a water bath at 19 ℃ to 21 ℃ for 3 times.
(II) test results:
the results of 1.3 experiments show that the D/E neutralized broth containing 5.0% Tween-80 and 2.0% sodium thiosulfate is suitable for the quantitative kill test of Mycobacterium cheloni subspecies abscission with 0.53%, 0.44% and 0.37% hydrogen peroxide sample stock solution prepared in examples 1-3.
2. And (3) identification test of a neutralizer: 3. the colony error rate between the 4 and 5 groups was 3.10%, 1.32% and 0.67%. Negative controls were all grown aseptically.
3. 3 times of repeated experiments show that the stock solution containing 0.53%, 0.44% and 0.37% of the hydrogen peroxide prepared in the examples 1-3 acts for 2.0min at the temperature of 19-21 ℃, and the killing logarithm value of mycobacterium cheloni abscess subspecies in the suspension is more than 4.00.
Test example 2 hydrogen peroxide disinfectant MRSA killing test
The first check basis is as follows:
1. the neutralizer identification test and the quantitative sterilization test are carried out according to 2.1.1.5.5 and 2.1.1.7.4 disinfection technical specifications (2002 edition) of Ministry of health;
2. and (3) identification test of a neutralizer: 2.0min, the tested strain is methicillin-resistant staphylococcus aureus (MRSA) ATCC 33591, the ATCC provides a primary freeze-drying tube, and 5 th and 6 th generation slant cultures are prepared for standby.
3. And (3) sterilization test: the samples of 0.53%, 0.44% and 0.37% hydrogen peroxide prepared in examples 1 to 3 were exposed to 4-fold dilutions in a water bath at 19 ℃ to 21 ℃ for 3 times.
(II) test results:
the results of 1.3 tests show that the D/E neutralized broth containing 5.0% Tween-80 and 2.0% sodium thiosulfate is suitable for the quantitative kill test of the methicillin-resistant Staphylococcus aureus (MRSA) with 0.53%, 0.44% and 0.37% hydrogen peroxide samples prepared in examples 1-3.
2. And (3) identification test of a neutralizer: 3. the colony error rates between the 4 and 5 groups were 2.77%, 3.56% and 2.41%. Negative controls were all grown aseptically.
3. Repeated experiments for 3 times show that the stock solutions containing 0.53%, 0.44% and 0.37% of hydrogen peroxide prepared in examples 1-3 act on MRSA for 1.0min at the temperature of 19-21 ℃, and the killing log values are all more than 5.00.
Experimental example 3-experiment of hydrogen peroxide disinfectant on air disinfecting effect (simulation site)
The first check basis is as follows:
1. the identification test of the neutralizer and the simulation of the field effect are carried out according to 2.1.5.5.6 and 2.1.3.4 disinfection technical specifications (2002 edition) of Ministry of health;
2. the tested strain is staphylococcus albus 8032, and a primary freeze-drying tube is provided by the common microorganism center of China Committee for culture Collection of microorganisms, and 5 th and 6 th generation slant cultures are prepared for later use. The bacterial aerosol generator is Collison CN-61.
3. And (3) disinfection test: the samples containing 0.53%, 0.44% and 0.37% of the hydrogen peroxide solutions obtained in examples 1 to 3 were put in an atomizer, and the atomization time was set to 6min42s (equivalent to an atomization amount of 100mL) to perform a sterilization test, and the tests were performed 3 times each.
(II) test results:
the results of 1.3 tests show that nutrient agar containing 2.0% sodium thiosulfate is suitable for the in-situ simulation and in-situ sterilization tests of 0.53%, 0.44%, 0.37% hydrogen peroxide-containing sample stock solutions prepared in examples 1-3.
2. And (3) identification test of a neutralizer: 3. the colony error rate between the 4 and 5 groups was 1.15%, 1.56% and 1.41%. Negative controls were all grown aseptically.
3. Repeated experiments for 3 times show that the sample stock solution containing 0.53%, 0.44% and 0.37% of hydrogen peroxide prepared in the example 1-3 is 5mL/m at the temperature of 19-21 ℃ and the relative humidity of 56-69%3The spraying agent is used for atomizing and acting for 30min, the killing rate of the white staphylococcus sprayed in the air of a simulation laboratory is more than 99.99 percent, and the natural decay rate of the white staphylococcus is 8.33-9.35 percent.
Test example 4 hydrogen peroxide disinfectant stability to acceleration test
Tests conducted in Table 1 below, according to the provisions of 2.2.3 in the Disinfection Specification (2002) show that the hydrogen peroxide disinfectants prepared in examples 1-3 are stored at 37 ℃ for 90 days, have a reduction rate of less than 3%, and have good stability and an expiration date of 24 months.
TABLE 1 accelerated stability test data for hydrogen peroxide disinfectant
| Initial | After 90 days of storage at 37 DEG C | Rate of decline | |
| Example 1 | 0.531％ | 0.518％ | 2.4％ |
| Example 2 | 0.443％ | 0.436％ | 1.6％ |
| Example 3 | 0.369％ | 0.365％ | 1.1％ |
The experiments prove that the hydrogen peroxide disinfectant can kill intestinal pathogenic bacteria, pyogenic coccus, pathogenic yeast, hospital infection common bacteria and mycobacteria, can inactivate viruses, can achieve a disinfection effect after acting for 2 minutes, and has good stability. Can be used for sterilizing environmental surfaces, various appliance products, equipment and facilities surfaces and air in various places such as medical health institutions, schools, nursery institutions, public places, food processing places, pharmaceutical industries, families and the like.
Claims (9)
1. A hydrogen peroxide disinfectant is characterized by comprising the following components in percentage by weight:
2. the hydrogen peroxide disinfectant according to claim 1, wherein the zinc/copper ions are zinc/copper salts of strong acids, and the strong acids are sulfuric acid or hydrochloric acid.
3. The hydrogen peroxide disinfectant according to claim 1, wherein the penetrant is an alcohol or ether containing a benzene ring.
4. The hydrogen peroxide disinfectant according to claim 3, wherein the alcohol or ether containing a benzene ring is benzyl alcohol or ethylene glycol phenyl ether.
5. The hydrogen peroxide disinfectant according to claim 1, wherein the surfactant is a zwitterionic surfactant.
6. The hydrogen peroxide disinfectant according to claim 5, wherein the zwitterionic surfactant is an ammonium oxide surfactant or a sulfobetaine surfactant.
7. The hydrogen peroxide disinfectant according to claim 1, wherein the stabilizer is an organophosphate.
8. The hydrogen peroxide disinfectant according to claim 7, wherein the organophosphate is hydroxyethylidene diphosphonic acid, diethylenetriamine pentamethylene phosphonic acid, 2-phosphonic acid butane-1, 2, 4-tricarboxylic acid, or ethylenediamine tetramethylene phosphonic acid.
9. A preparation method of a hydrogen peroxide disinfectant is characterized by comprising the following steps:
adding purified water into a proportioning container, sequentially adding the purified water, a stabilizing agent, a surfactant, a penetrating agent, citric acid, zinc ions/copper ions and hydrogen peroxide in percentage by weight, and uniformly stirring to obtain the hydrogen peroxide disinfectant.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113273579A (en) * | 2021-06-04 | 2021-08-20 | 天津尚蒙科技有限公司 | Low-temperature composite disinfectant and preparation method thereof |
| CN114304144A (en) * | 2021-11-23 | 2022-04-12 | 山东新华莎罗雅生物技术有限公司 | Sporicide capable of killing spores and preparation method thereof |
| CN114467971A (en) * | 2020-11-11 | 2022-05-13 | 上海利康消毒高科技有限公司 | Hydrogen peroxide disinfectant and preparation method thereof |
| CN114668680A (en) * | 2022-03-15 | 2022-06-28 | 湖北微控生物科技有限公司 | Washing-free quick-drying hand disinfectant capable of killing viruses |
| CN114747568A (en) * | 2022-04-27 | 2022-07-15 | 山东利尔康医疗科技股份有限公司 | Medium-level disinfection wet tissue and preparation method thereof |
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| CN102802677A (en) * | 2009-06-29 | 2012-11-28 | 美你康株式会社 | System for sterilizing contact lens |
| CN107519744A (en) * | 2017-09-15 | 2017-12-29 | 安徽中弘科技发展有限公司 | A kind of furniture eliminating smell agent and preparation method thereof |
| CN107836462A (en) * | 2017-11-08 | 2018-03-27 | 衡阳市食品药品检验检测中心 | Suitable for the pseudomonas aeruginosa disinfectant and method for disinfection of barreled drinking water production |
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2019
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102802677A (en) * | 2009-06-29 | 2012-11-28 | 美你康株式会社 | System for sterilizing contact lens |
| CN107519744A (en) * | 2017-09-15 | 2017-12-29 | 安徽中弘科技发展有限公司 | A kind of furniture eliminating smell agent and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114467971A (en) * | 2020-11-11 | 2022-05-13 | 上海利康消毒高科技有限公司 | Hydrogen peroxide disinfectant and preparation method thereof |
| CN113273579A (en) * | 2021-06-04 | 2021-08-20 | 天津尚蒙科技有限公司 | Low-temperature composite disinfectant and preparation method thereof |
| CN114304144A (en) * | 2021-11-23 | 2022-04-12 | 山东新华莎罗雅生物技术有限公司 | Sporicide capable of killing spores and preparation method thereof |
| CN114668680A (en) * | 2022-03-15 | 2022-06-28 | 湖北微控生物科技有限公司 | Washing-free quick-drying hand disinfectant capable of killing viruses |
| CN114747568A (en) * | 2022-04-27 | 2022-07-15 | 山东利尔康医疗科技股份有限公司 | Medium-level disinfection wet tissue and preparation method thereof |
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