CN111743949A

CN111743949A - Hemorrhoid comforting ointment and preparation method thereof

Info

Publication number: CN111743949A
Application number: CN202010797837.9A
Authority: CN
Inventors: 任日旺
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-08-10
Filing date: 2020-08-10
Publication date: 2020-10-09

Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a hemorrhoid comforting ointment and a preparation method thereof, wherein the hemorrhoid comforting ointment comprises the following raw materials in parts by weight: 61-63 parts of coptis chinensis, 15-16 parts of borax, 30-32 parts of indigo naturalis, 30-32 parts of golden cypress, 30-32 parts of gallnut, 30-32 parts of angelica dahurica and 2-3 parts of borneol. The hemorrhoid comforting paste has the effects of clearing heat and drying dampness, relieving swelling and activating blood circulation to promote tissue regeneration, removing putrefaction and relieving pain, hits the pathology of hemorrhoids, has good and quick curative effect on hemorrhoids, perianal abscess, anal fissure, anal fistula, external hemorrhoid swelling and pain and perianal diseases, has better effect compared with a market plaster, does not contain musk, and is suitable for various crowds.

Description

Hemorrhoid comforting ointment and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to hemorrhoid comforting ointment and a preparation method thereof.

Background

Hemorrhoids are common clinical multiple diseases, and are mostly caused by turbid qi and blood stasis and flow into anus due to factors such as stagnation of damp-heat, downward flow of damp-heat or spleen deficiency and qi flame, or sedentary blood vessel obstruction, constipation, intra-abdominal high pressure, diarrhea and dysentery. The hemorrhoids are formed by the rupture of perianal subcutaneous veins and the blood deposition under the skin; patients often complain of self-detection of anal swelling, pain and foreign body sensation in clinic, and grape-shaped dark purple tumors are found around the anus or under the anus and sometimes accompanied with surface mild erosive bleeding; it is manifested as pain, hematochezia, incarceration and prolapse of internal hemorrhoid, edema of skin flap, slow regression, and erosion of surface of hemorrhoid complicated with infection with secretion and odor. In Western medicine, soft vein group formed by expansion and buckling of the submucosal plexus of the tail end of the rectum and the inferior vein plexus of the anal canal skin of a human body is called hemorrhoid, which comprises internal hemorrhoid, external hemorrhoid and mixed hemorrhoid, wherein the main clinical manifestations of the external hemorrhoid are pain and anal skin bulge; the main clinical manifestations of internal hemorrhoids are hemafecia, with larger internal hemorrhoids associated with prolapse, incarceration and pain; the clinical manifestations of mixed hemorrhoids are bloody stool and pain, and the heavier mixed hemorrhoids can form a ring around the anus, also known as ring-shaped mixed hemorrhoids. The hemorrhoids bring great pain to patients, the pain is severe, the movement is limited, and even the patients are uneasy to sit and lie, the existing treatment methods for the hemorrhoids are more, the western medicine usually adopts hemorrhoid treatment, operation treatment, oral medication or external medication, the oral medication or external medication is easy to repeatedly attack and can not be eradicated; the hemorrhoids after the therapy of the hemorrhoids with dry hemorrhoids or the operation therapy have longer recovery time, are easy to cause the recurrence and have low cure rate.

The traditional Chinese medicine in the prior art usually takes external medicines as main materials, and in order to improve the drug effect of the hemorrhoid ointment, musk is added into a large amount of hemorrhoid ointments, has the functions of easing pain, activating blood, resolving masses and reducing swelling, but also has the defects of breaking blood and dissolving stasis, so that the hemorrhoid ointment is not suitable for pregnant women and can cause other complicating diseases of women.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide the hemorrhoid comforting ointment and the preparation method thereof, the hemorrhoid comforting ointment prepared by the invention has the effects of clearing heat and drying dampness, reducing swelling, activating blood and promoting tissue regeneration, and removing putrefaction and relieving pain, hits the pathology of hemorrhoid, has good and quick curative effect on hemorrhoid, perianal abscess, anal fissure, anal fistula, external hemorrhoid gall and perianal diseases, has better effect compared with a market plaster, is not added with musk, and is suitable for various groups of people.

In order to solve the technical problems, the invention adopts the following technical scheme:

the hemorrhoid comforting ointment consists of the following components in parts by weight: 61-63 parts of coptis chinensis, 15-16 parts of borax, 30-32 parts of indigo naturalis, 30-32 parts of golden cypress, 30-32 parts of gallnut, 30-32 parts of angelica dahurica and 2-3 parts of borneol.

Preferably, the composition consists of the following components in parts by weight: 63 parts of coptis chinensis, 16 parts of borax, 32 parts of indigo naturalis, 32 parts of golden cypress, 32 parts of gallnut, 32 parts of angelica dahurica and 3 parts of borneol.

The invention also provides a preparation method of the hemorrhoid comforting ointment, which comprises the following steps:

step one, weighing the following raw materials in parts by weight: 61-63 parts of coptis chinensis, 15-16 parts of borax, 30-32 parts of indigo naturalis, 30-32 parts of golden cypress, 30-32 parts of gallnut, 30-32 parts of angelica dahurica and 2-3 parts of borneol for later use;

step two, drying the coptis chinensis, the golden cypress, the gallnut and the angelica dahurica together, crushing and sieving by a sieve of 60-200 meshes to obtain fine powder;

step three, uniformly mixing the heated vaseline and the fine powder obtained in the step two, cooling to paste, adding borax, borneol and indigo naturalis, and uniformly mixing to obtain a plaster;

wherein the mass ratio of the total weight of the raw materials to the vaseline is 5: 1-1.5;

step four, adding sesame oil into the plaster obtained in the step three to obtain hemorrhoid comforting plaster;

wherein the mass ratio of the total weight of the raw materials and the vaseline to the sesame oil is 10: 0.15-0.25;

and fifthly, instantly sterilizing at high temperature and bottling.

Preferably, the high-temperature instantaneous sterilization conditions of the step five are as follows: keeping the temperature at 110-120 ℃ for 2-3 minutes until the finished product reaches a commercial sterile state.

The action mechanism of the traditional Chinese medicine composition is as follows:

monarch drug: coptis chinensis;

ministerial drugs: borax;

adjuvant drugs: indigo naturalis, cortex phellodendri, borneol:

a messenger drug: gallnut and angelica dahurica;

coptis chinensis: bitter and cold. The large intestine meridian of heart, liver and stomach; clearing heat, eliminating dampness, purging pathogenic fire, removing toxic substances, and resisting bacteria; has excellent killing effect on gram-negative bacteria in intestinal tracts such as escherichia coli, dysentery bacillus, typhoid bacillus, vibrio cholerae and the like, and has excellent treatment effect on carbuncle, furuncle and eczema and eczema.

Borax: sweet, salty and cool, enter lung and stomach meridians, and are externally used for clearing away heat and toxic materials, relieving swelling and preventing corrosion, and sterilizing.

Indigo naturalis: salty and cold, good at the heart meridian, lung meridian and stomach meridian; the external use for treating eczema and pyocutaneous disease has the effects of clearing heat and drying dampness, cooling blood and removing ecchymoses, clearing liver and purging fire, and has the inhibiting effect on dermatophyte.

Yellow golden section: bitter and cold. Entering kidney, bladder and large intestine meridians; external sore, ulcer, burn, eczema, etc.; clearing heat and drying dampness, purging fire and removing toxicity, and eliminating deficiency heat, has stronger effect on cryptococcus neoformans and red zymophyte, has stronger sterilizing effect on cryptococcus neoformans and red zymophyte than nystatin by golden cypress, and has inhibiting effect on fungi on candida albicans.

Gallnut: sour, astringent and cold in nature; entering lung, large intestine and kidney meridians; stop bleeding, astringe dampness and heal wound, reduce fire and stop sweating, astringe sword and stop bleeding.

Radix angelicae: pungent and warm. Entering lung, stomach and spleen meridians; has the effects of relieving swelling and pain, expelling toxin and pus, and expelling pus; also has effects in relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, inducing resuscitation, eliminating dampness, relieving stagnation, relieving swelling, relieving itching, resisting infection, and relieving pain.

Borneol: pungent, bitter and slightly cold. Heart, spleen and lung meridians entered; the external use can clear away heat and toxic material, relieve swelling and pain and ulcerate, relieve swelling and pain and promote granulation, induce resuscitation and refresh mind, clear away heat and relieve pain.

The invention has the functions of clearing heat and drying dampness, reducing swelling, activating blood circulation, promoting granulation, removing necrotic tissue and relieving pain; and no musk is used, and contraindications are avoided.

The traditional Chinese medicine composition has reasonable compatibility of raw materials, is reasonably matched according to monarch, minister, assistant and guide, has proper formula, and aims at treating pathogenesis after occurrence of hemorrhoids, perianal abscess, anal fissure, anal fistula, external hemorrhoid gall, perianal diseases and the like, namely wind, dampness, summer heat, fire, heat and dryness, particularly wind, dampness, dryness and heat, for example, the four pathogenic factors are described in the' surgical patent of "swelling with dampness, pain and fire, itching people wind and clockness people dryness. In the four pathogens, dampness and heat are the most serious damage. The coptis chinensis is taken as a monarch drug, has the effects of clearing heat, drying dampness, purging fire, detoxifying and resisting bacteria, the coptis chinensis is used for tightly cutting the disease root of the hemorrhoid, namely damp-heat, so that the problem of drying dampness caused by damp-heat middle-blocking is effectively solved, accumulated damp-heat is removed, the phenomena of anus qi-blood aspect and qi-blood block and coagulation are solved, the anus channels and collaterals are dredged, gram-negative bacteria in intestinal tracts are killed, and the coptis chinensis is used for resisting bacteria, diminishing inflammation, relieving pain, clearing heat and detoxifying aiming at the inflammation caused by the hemorrhoid, so that the dampness, the swelling and pain and the inflammation; borax is used as a ministerial drug for detumescence and antisepsis, and delaying the decay caused by microorganism growth or chemical change, and a monarch drug is used for assisting the effects of clearing away heat and toxic material, sterilizing and disinfecting, and the monarch drug and the ministerial drug are used together to quickly relieve the symptoms of gall and grasp the pathogenesis of wind, dampness, fire and heat of hemorrhoids; indigo naturalis, borneol and golden cypress are taken as adjuvant drugs, the indigo naturalis is, golden cypress and borneol are used for treating eczema, sore and ulcer and gall ulcer externally, the swelling and pain relieving and tissue regeneration are realized, dermatophyte, cryptococcus neoformans and red zymophyte are inhibited, monarch drugs and ministerial drugs are assisted to strengthen the treatment effect, the swelling and pain relieving and tissue regeneration are realized while the eczema, the sore and ulcer and the gall ulcer are treated, and the pathogenesis of dryness is solved; the Chinese gall and the angelica dahurica are used as conductant drugs, and the effects of externally collecting the sword and stopping bleeding, expelling toxin and pus and expelling pus in the interior are achieved, so that the monarch drug, the ministerial drug and the adjuvant drug can play more excellent roles.

The hemorrhoid soothing paste traditional Chinese medicine composition has a remarkable prevention effect, can quickly treat the hemorrhoid, perianal abscess, anal fissure, anal fistula, external hemorrhoid gall and causes of perianal diseases, and has the advantages of quick response, good effect and difficult recurrence; in addition, the ointment does not contain musk, is suitable for different people, and results show that compared with the traditional Chinese medicine hemorrhoid ointment in the prior art, the ointment has faster curative effect and fewer complications.

Detailed Description

The following description will be made by reference to preferred embodiments 1 to 3 in conjunction with the embodiments of the present invention.

Example 1

A preparation method of the hemorrhoid comforting ointment comprises the following steps:

step one, weighing the following raw materials in parts by weight: 61 parts of coptis chinensis, 15 parts of borax, 30 parts of indigo naturalis, 30 parts of golden cypress, 30 parts of gallnut, 30 parts of angelica dahurica and 2 parts of borneol for later use;

step two, drying the coptis chinensis, the golden cypress, the gallnut and the angelica dahurica together, crushing and sieving by a 200-mesh sieve to obtain fine powder;

wherein the mass ratio of the total weight of the raw materials to the vaseline is 5: 1;

wherein the mass ratio of the total weight of the raw materials and the vaseline to the sesame oil is 10: 0.15;

and step five, keeping the temperature for 3 minutes at 110 ℃, carrying out high-temperature instantaneous sterilization until the finished product reaches a commercial sterile state, and bottling.

Example 2

step one, weighing the following raw materials in parts by weight: 62 parts of coptis chinensis, 15 parts of borax, 31 parts of indigo naturalis, 31 parts of golden cypress, 31 parts of gallnut, 31 parts of angelica dahurica and 3 parts of borneol for later use;

step two, drying the coptis chinensis, the golden cypress, the gallnut and the angelica dahurica together, crushing and sieving by a 160-mesh sieve to obtain fine powder;

wherein the mass ratio of the total weight of the raw materials to the vaseline is 5: 1.2;

wherein the mass ratio of the total weight of the raw materials and the vaseline to the sesame oil is 10: 0.2;

and step five, keeping the temperature at 115 ℃ for 3 minutes, carrying out high-temperature instantaneous sterilization until the finished product reaches a commercial sterile state, and bottling.

Example 3

step one, weighing the following raw materials in parts by weight: 63 parts of coptis chinensis, 16 parts of borax, 32 parts of indigo naturalis, 32 parts of golden cypress, 32 parts of gallnut, 32 parts of angelica dahurica and 3 parts of borneol for later use;

step two, drying the coptis chinensis, the golden cypress, the gallnut and the angelica dahurica together, crushing and sieving by a 60-mesh sieve to obtain fine powder;

wherein the mass ratio of the total weight of the raw materials to the vaseline is 5: 1.5;

wherein the mass ratio of the total weight of the raw materials and the vaseline to the sesame oil is 10: 0.25;

and step five, keeping the temperature at 120 ℃ for 2 minutes, carrying out high-temperature instantaneous sterilization until the finished product reaches a commercial sterile state, and bottling.

Comparative example 1

Mayilong ointment.

Comparative example 2

Jiuhua ointment.

The hemorrhoid comforting ointment provided by the embodiments 1 to 3 of the present invention all have significant treatment effects on hemorrhoids, perianal abscess, anal fissure, anal fistula, external hemorrhoid swelling and pain and perianal diseases, and since the treatment effects of the hemorrhoid comforting ointment of the embodiments 1 to 3 are substantially parallel, the effect of the present invention is illustrated by taking the traditional Chinese medicine composition of the embodiment 32 as an example, and specific test examples include toxicity tests, anti-inflammatory tests, pharmacodynamic tests and clinical tests, which are specifically shown as follows:

firstly, toxicity test:

taking 20 rats with the weight of 200-;

after the experiment is started, the hairs on the back of the trunk of the animal are removed, the hair-removed area accounts for about 10% of the surface area of the body of a rat, then the hemorrhoid comforting ointment prepared by the invention is uniformly smeared on the hair-removed area, the dose is 5000mg/kg of the body weight, a layer of thin film is used for covering, a non-irritant adhesive plaster is used for fixing, and then observation is carried out for 24 hours; after the observation is finished for 24 hours, cleaning the tested rat by using clear water, and continuously observing for 14 days; the tested rat has no poisoning and death phenomenon within 24h, and has no tremor, convulsion, salivation, diarrhea, lethargy, coma and other phenomena, the appearance, fur and skin color of the animal have no abnormal change, no abnormal breathing exists, and no abnormal secretion exists in the nose, eyes and oral cavity. And the behavioral activities in the 14d later are not abnormal and have no great difference with the blank control group; the once-limiting method is adopted to detect that the test object with low toxicity does not cause animal death, which indicates that the hemorrhoid comforting ointment prepared by the invention can be used in large dose.

II, anti-inflammatory experiment:

50 SD rats with the weight of 180-. Marking the ankle joints of the right hind limbs of the rats by using a marker pen before the experiment, and administering corresponding medicines of each group at the marked positions for 3-4 days continuously; the foot swelling degree (the swelling degree of foot is the volume of foot after inflammation-volume of foot before inflammation) is calculated by a daily foot volume measuring device in the experiment. The corresponding drugs are respectively administered at the marked positions of rats at the present day, and after lh administration of the drugs, 0.1 lml/rat of 1% carrageenan is injected into the right plantar skin marked by each rat intradermally to cause inflammation; the volume of the right hind paw of the mouse is measured 30min, 60min and 120min after inflammation, and the swelling degree of the hind paw after inflammation is recorded for 30min, 60min and 120 min. Shearing inflammatory feet below the ankle joint, weighing, placing in 2ml of physiological saline, fully shearing, homogenizing, centrifuging (3000rpm for 5min), taking supernatant, detecting SOD and MDA contents with a kit, and detecting IL-1 content of the supernatant by an ELISA method; the measurement results are shown in tables 1 and 2:

TABLE 1 comparison of swelling after inflammation

By contrast, after equal amounts of hemorrhoid comforting ointment, marigold and Jiuhua ointment are used, the swelling degree of feet is relieved to a certain extent, which shows that the medicines of the examples and the comparative examples can inhibit acute inflammation of rats caused by carrageenan, the relieving degree of the examples at 120min is better than that of the comparative examples, and the inhibiting effect of the examples is better and the inflammation is relieved more quickly.

TABLE 2 comparison of the results of SOD, MDA and IL-1 in the inflamed tissues of the feet of rats after inflammation

The results in table 2 show that the SOD content of the hemorrhoid comforting ointment prepared by the invention is obviously higher than that of the ointment in the market, and the MDA and IL-1 are obviously lower than that of long-term ointment, which shows that the hemorrhoid comforting ointment of the invention has more excellent inhibition effect on inflammatory cells.

Thirdly, pharmacodynamic experiment:

the clinical observation of the hemorrhoid comforting ointment prepared by the invention is compared with the hemorrhoid ointment on the market, and the comparison is as follows:

selecting 180 cases with mixed hemorrhoids, wherein the market of the ointment is better in 4-8 days, and the medicine is exchanged for 1 time each day; the ointment for treating hemorrhoid is improved after 2-5 days, and the ointment is changed for 1 time every day, and pain is relieved on the day. 230 anal fissures, the market ointment improves in 5-15 days, the medicine is changed for 1 time every day, the hemorrhoid comforting ointment is changed for 4-10 days, and the medicine is changed for 1 time every day. The perianal abscess can be treated by exchanging the medicine for 1 time every day for 4-20 days. The hemorrhoid comforting ointment of Shengshichuang is 2-12, the medicine is changed 1 time every day, and the whole case is treated according to the disease condition by matching with the operation.

TABLE 3 comparison of the pharmacological effects of hemorrhoid ointment and ointment on the market

Item	Mixed hemorrhoid (Tian)	Anal fissure (Tian)	Perianal abscess (Tian)
				Example 1	2-5	4-10	4-20
Comparative example 1	4-8	5-15	2-12

Improvement: the pain is relieved, the pain is not felt when walking, and the hemorrhoids are reduced;

and (3) curing: the hemorrhoids disappear, the pain stops, the stool does not bleed, and the swelling disappears.

The result shows that the hemorrhoid comforting ointment prepared by the invention has quick curative effect and short cure time, and has more excellent effect compared with the long-time ointment in the prior art.

Fourthly, clinical trial:

certain Liu, woman, age 33; admission at 11/9/2016 and discharge at 3/17/2016; and (3) diagnosis: anal fissure, mixed hemorrhoid; the total treatment time is 8 days, the pain is improved after the patient is admitted for 2 days, and the pain is relieved in the same day; the patient is discharged after 8 days; no relapse occurs after 2 years of study.

White certain, female, age 67; diagnosis, anal fistula, mixed hemorrhoids; the patient is admitted at 10 days of 12 months and 10 months in 2016, and is discharged at 10 days of 12 months and 20 months in 2016; the total treatment time is 10 days by using the hemorrhoid comforting ointment; after the patient is admitted, the flaccid tube mixed hemorrhoid resection is carried out, then the medicine is exchanged every day, the pain is relieved on the day of postoperative medicine exchange, the patient is completely cured and discharged after 10 days, and no relapse occurs after 2 years of inert visit.

Zhangyi, woman, age 55; diagnosis, mixed hemorrhoid, perianal abscess; admission at 2016, 11, 28, 12, and discharge at 2016, 12, 7, 9; the hemorrhoids-relieving ointment is used for treating the hemorrhoids and is discharged after 8 days of hospital recovery, and no relapse occurs after 2 years of study.

Yan somebody, woman, 26 years old; and (3) diagnosis: anal fissure is admitted at 2016, 12 and 9 days, and discharged at 2017, 1 and 15 days, and the total number of hospitalization days is 15 days. The ointment in the ointment market is less than Jiuhua ointment, and the Mayilong hemorrhoids ointment has no relapse after more than 2 years of inert visit.

Comparative group 2: von of someone, women, age 42; diagnosing mixed hemorrhoid and perianal abscess; the method records that the patient is admitted in 2016, discharged in 19 days in 1 month and 2017, and discharged in 20 days in total. The treatment medicine is Jiuhua plaster, Mayilong hemorrhoid plaster, and has no recurrence after 2 years of study.

Clinical experiments show that the hemorrhoid comforting ointment generally needs 8-10 days for curing, and the market medicines < Jiuhua ointment and Mayilong hemorrhoid ointment > for curing generally need 15-20 days, so that the hemorrhoid comforting ointment prepared by the invention is also verified to have quick effect, no recurrence is seen in 2 years, and the curative effect is good.

It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.

Claims

1. The hemorrhoid comforting ointment is characterized by comprising the following components in parts by weight: 61-63 parts of coptis chinensis, 15-16 parts of borax, 30-32 parts of indigo naturalis, 30-32 parts of golden cypress, 30-32 parts of gallnut, 30-32 parts of angelica dahurica and 2-3 parts of borneol.

2. The hemorrhoid comforting cream according to claim 1, which is prepared from the following components in parts by weight: 63 parts of coptis chinensis, 16 parts of borax, 32 parts of indigo naturalis, 32 parts of golden cypress, 32 parts of gallnut, 32 parts of angelica dahurica and 3 parts of borneol.

3. The method for preparing hemorrhoid relaxing cream according to claim 1, comprising the steps of:

and fifthly, instantly sterilizing at high temperature and bottling.

4. The method for preparing hemorrhoid comforting ointment according to claim 3, wherein the high-temperature instant sterilization conditions in the fifth step are as follows: keeping the temperature at 110-120 ℃ for 2-3 minutes until the finished product reaches a commercial sterile state.