CN111420063A - A Chinese medicinal preparation containing ionized calcium for improving drug effect, and its preparation method - Google Patents
A Chinese medicinal preparation containing ionized calcium for improving drug effect, and its preparation method Download PDFInfo
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- CN111420063A CN111420063A CN202010243213.2A CN202010243213A CN111420063A CN 111420063 A CN111420063 A CN 111420063A CN 202010243213 A CN202010243213 A CN 202010243213A CN 111420063 A CN111420063 A CN 111420063A
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- traditional chinese
- ionized calcium
- chinese medicine
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 40
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 40
- 239000011575 calcium Substances 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 39
- 230000000857 drug effect Effects 0.000 title claims abstract description 18
- 239000003814 drug Substances 0.000 claims abstract description 51
- 238000002156 mixing Methods 0.000 claims abstract description 44
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 25
- 150000007524 organic acids Chemical class 0.000 claims abstract description 17
- 235000000832 Ayote Nutrition 0.000 claims abstract description 14
- 235000009854 Cucurbita moschata Nutrition 0.000 claims abstract description 14
- 240000001980 Cucurbita pepo Species 0.000 claims abstract description 14
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 claims abstract description 14
- 235000010987 pectin Nutrition 0.000 claims abstract description 14
- 229920001277 pectin Polymers 0.000 claims abstract description 14
- 239000001814 pectin Substances 0.000 claims abstract description 14
- 235000015136 pumpkin Nutrition 0.000 claims abstract description 14
- 239000003651 drinking water Substances 0.000 claims abstract description 8
- 235000020188 drinking water Nutrition 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 23
- 238000003756 stirring Methods 0.000 claims description 17
- 239000007788 liquid Substances 0.000 claims description 14
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 9
- 102000008186 Collagen Human genes 0.000 claims description 9
- 108010035532 Collagen Proteins 0.000 claims description 9
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 9
- 229920001436 collagen Polymers 0.000 claims description 9
- 235000019674 grape juice Nutrition 0.000 claims description 9
- 235000015201 grapefruit juice Nutrition 0.000 claims description 9
- 239000001630 malic acid Substances 0.000 claims description 9
- 235000011090 malic acid Nutrition 0.000 claims description 9
- 235000016709 nutrition Nutrition 0.000 claims description 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 9
- PIGTXFOGKFOFTO-FVFWYJKVSA-N (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-carboxy-4-formyl-8-hydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound O([C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)C[C@@H](O)[C@]1(CCC(C[C@H]14)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O PIGTXFOGKFOFTO-FVFWYJKVSA-N 0.000 claims description 7
- 235000012239 silicon dioxide Nutrition 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims 6
- 239000000825 pharmaceutical preparation Substances 0.000 claims 5
- 230000002708 enhancing effect Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 abstract description 3
- -1 compound vitamin Chemical class 0.000 abstract description 3
- 239000011782 vitamin Substances 0.000 abstract description 3
- 229940088594 vitamin Drugs 0.000 abstract description 3
- 229930003231 vitamin Natural products 0.000 abstract description 3
- 235000013343 vitamin Nutrition 0.000 abstract description 3
- 230000035699 permeability Effects 0.000 abstract description 2
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 5
- PIGTXFOGKFOFTO-PPEDVFHSSA-N CC1(C)CC[C@@]2([C@H](O)C[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CCC(O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)[C@@](C)(C=O)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O Chemical compound CC1(C)CC[C@@]2([C@H](O)C[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CCC(O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)[C@@](C)(C=O)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O PIGTXFOGKFOFTO-PPEDVFHSSA-N 0.000 abstract 1
- 235000017784 Mespilus germanica Nutrition 0.000 description 9
- 244000182216 Mimusops elengi Species 0.000 description 9
- 235000000560 Mimusops elengi Nutrition 0.000 description 9
- 235000007837 Vangueria infausta Nutrition 0.000 description 9
- 230000000694 effects Effects 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000009835 boiling Methods 0.000 description 1
- 229910052956 cinnabar Inorganic materials 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052957 realgar Inorganic materials 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Alternative & Traditional Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a traditional Chinese medicine preparation containing ionized calcium and having improved drug effect and a preparation method thereof, wherein the traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 30-45% of ionized calcium; 5-15% of drinking water; 2-3% of a synergist; 12-22% of a blending agent; 1-3% of edible organic acid; 0.5-2% of compound vitamin; 0.8-2% of edible quillajasaponins; 2-4% of pumpkin pectin, the traditional Chinese medicine decoction method has the advantages that the complexity of traditional decoction of traditional Chinese medicines is reduced, the problem that the medicine property of the traditional Chinese medicines is evaporated through steam when the traditional Chinese medicines are repeatedly decocted is solved, the effective components of the traditional Chinese medicines are reserved, and the effective utilization of the traditional Chinese medicines is improved; by adding the traditional Chinese medicine preparation, only 20-30% of the components of the normally-open traditional Chinese medicine prescription are needed, so that the cost is saved, and the traditional Chinese medicine preparation is simple and convenient; the active ingredients of the traditional Chinese medicine can be fully exerted and utilized by utilizing the strong permeability of the ionized calcium to activate the performance of the medicine.
Description
Technical Field
The invention relates to the technical field of dry tablet preparations, in particular to a traditional Chinese medicine preparation containing ionized calcium and having the effect of improving the drug effect and a preparation method thereof.
Background
Traditional chinese medicine decocting device is the casserole, traditional chinese medicine jar etc, boil the in-process, need the people for stirring, make the active ingredient of traditional chinese medicine fully appear, prevent simultaneously that traditional chinese medicine from pasting in the device bottom, consequently, the system efficiency of stewing of current traditional chinese medicine decocting device is lower, the user uses and experiences the sense also very poorly, some medicinal materials are in system in-process in addition, should be high breakage, through filtering, the drug effect has appeared reducing, it can fall the unable this demand of satisfying of property of a medicine through steam evaporation obviously to decoct repeatedly current traditional chinese medicine, user experience is poor, current traditional chinese medicine system boils and all needs manual water of adding in addition, then heat through indirect heating mode, so heating time is longer, user experience has also been reduced, consequently, current traditional chinese medicine exists to boil inefficiency and user experience the poor defect of sense.
Disclosure of Invention
The invention provides a traditional Chinese medicine preparation containing ionized calcium and having improved drug effect and a preparation method thereof.
The scheme of the invention is as follows:
a traditional Chinese medicine preparation containing ionized calcium and having efficacy improving function comprises the following raw materials in parts by weight:
the preferable technical scheme comprises the following raw materials in parts by weight:
as a preferred technical scheme, the synergist is concretio silicea bambusae.
As a preferred technical scheme, the blender is grape juice or grapefruit juice.
Preferably, the edible organic acid comprises malic acid and citric acid.
Preferably, the nutritional agent comprises collagen peptide.
The invention also provides a preparation method of the traditional Chinese medicine preparation containing ionized calcium, which has the effect of improving the drug effect, and comprises the following steps:
1) stirring and mixing 0.2-0.6% by weight of pumpkin pectin, 0.8-2% by weight of edible quillaja saponin, 0.5-2% by weight of multivitamin and 2-3% by weight of synergist, and mixing the mixture for later use;
2) blending 30-45% of ionized calcium and 5-15% of drinking water by weight to obtain a mixed liquid;
3) mixing 1-3% of edible organic acid and 12-22% of blending agent by weight, adding the mixture obtained in the step 1) and the mixed liquid obtained in the step 2) into the mixture, and stirring to obtain the traditional Chinese medicine preparation containing ionized calcium with improved drug effect.
As a preferable technical scheme, the pumpkin pectin in the step 1) is heated to 35-40 ℃ for use.
According to a preferable technical scheme, the synergist is tabasheer, the blending agent is grape juice or grapefruit juice, the edible organic acid comprises malic acid and citric acid, and the nutritional agent comprises collagen peptide.
Due to the adoption of the technical scheme, the traditional Chinese medicine preparation containing ionized calcium and having the effect of improving the drug effect and the preparation method thereof comprise the following steps:
1) stirring and mixing 0.2-0.6% by weight of pumpkin pectin, 0.8-2% by weight of edible quillaja saponin, 0.5-2% by weight of multivitamin and 2-3% by weight of synergist, and mixing the mixture for later use; 2) blending 30-45% of ionized calcium and 5-15% of drinking water by weight to obtain a mixed liquid; 3) mixing 1-3% of edible organic acid and 12-22% of blending agent by weight, adding the mixture obtained in the step 1) and the mixed liquid obtained in the step 2) into the mixture, and stirring to obtain the traditional Chinese medicine preparation containing ionized calcium with improved drug effect.
The invention has the advantages that:
1. the complexity of traditional decoction of the traditional Chinese medicine is reduced, the problem that the property of the traditional Chinese medicine is evaporated by steam when the traditional Chinese medicine is repeatedly decocted is solved, the effective components of the traditional Chinese medicine are reserved, and the effective utilization of the components of the traditional Chinese medicine is improved;
2. by adding the traditional Chinese medicine preparation, the effect can be achieved only by 20-30% of the weight of the normally-open traditional Chinese medicine formula, so that the cost is saved, and the traditional Chinese medicine preparation is simple and convenient;
3. the active ingredients of the traditional Chinese medicine can be fully exerted and utilized by utilizing the strong permeability of the ionized calcium to activate the performance of the medicine.
4. The absorption rate of the traditional Chinese medicine prescription after the traditional Chinese medicine prescription is used by a user can be effectively improved, and the absorption capacity of traditional Chinese medicine components of the user is improved after the traditional Chinese medicine prescription is used by the user, so that the drug effect is enhanced;
5. through mouse experiments, after the traditional Chinese medicine composition is used with a prescription, toxic and side effects of the prescription containing cinnabar and realgar can be reduced.
Detailed Description
In order to make up for the above deficiencies, the present invention provides a traditional Chinese medicine preparation containing ionized calcium with improved drug effect and a preparation method thereof to solve the problems in the background art.
A Chinese medicinal preparation containing ionized calcium with improved drug effect and its preparation method are provided, which comprises the following steps:
a traditional Chinese medicine preparation containing ionized calcium and having efficacy improving function comprises the following raw materials in parts by weight:
comprises the following raw materials in parts by weight:
the synergist is concretio silicea Bambusae seu Schizostachyi.
The blending agent is grape juice or grapefruit juice.
The edible organic acid comprises malic acid and citric acid.
The nutritional agent includes collagen peptides.
The invention also provides a preparation method of the traditional Chinese medicine preparation containing ionized calcium, which has the effect of improving the drug effect, and comprises the following steps:
1) stirring and mixing 0.2-0.6% by weight of pumpkin pectin, 0.8-2% by weight of edible quillaja saponin, 0.5-2% by weight of multivitamin and 2-3% by weight of synergist, and mixing the mixture for later use;
2) blending 30-45% of ionized calcium and 5-15% of drinking water by weight to obtain a mixed liquid;
3) mixing 1-3% of edible organic acid and 12-22% of blending agent by weight, adding the mixture obtained in the step 1) and the mixed liquid obtained in the step 2) into the mixture, and stirring to obtain the traditional Chinese medicine preparation containing ionized calcium with improved drug effect.
The pumpkin pectin in the step 1) is heated to 35-40 ℃ for use.
The synergist is tabasheer, the blending agent is grape juice or grapefruit juice, the edible organic acid comprises malic acid and citric acid, and the nutritional agent comprises collagen peptide.
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
Example 1:
1) stirring and mixing 0.2% of pumpkin pectin, 0.8% of edible quillaja saponin, 0.5% of compound vitamin and 2% of synergist by weight, and mixing the mixture for later use;
2) mixing 30% of ionized calcium and 5% of drinking water by weight to obtain a mixed liquid;
3) mixing 1% of edible organic acid and 12% of blending agent by weight, then adding the mixture obtained in the step 1) and the mixed liquid obtained in the step 2) into the mixture at the same time, and stirring to obtain the traditional Chinese medicine preparation containing ionized calcium with improved drug effect.
The pumpkin pectin in the step 1) is heated to 35 ℃ for use.
The synergist is tabasheer, the blending agent is grape juice or grapefruit juice, the edible organic acid comprises malic acid and citric acid, and the nutritional agent comprises collagen peptide.
Example 2:
1) stirring and mixing 0.6% of pumpkin pectin, 2% of edible quillaja saponin, 2% of multivitamin and 3% of synergist by weight, and mixing the mixture for later use;
2) blending 45% of ionized calcium and 15% of drinking water by weight to obtain a mixed liquid;
3) mixing 3% of edible organic acid and 22% of blending agent by weight, then adding the mixture obtained in the step 1) and the mixed liquid obtained in the step 2) into the mixture at the same time, and stirring the mixture to obtain the traditional Chinese medicine preparation containing ionized calcium with improved efficacy.
The pumpkin pectin in the step 1) is heated to 40 ℃ for use.
The synergist is tabasheer, the blending agent is grape juice or grapefruit juice, the edible organic acid comprises malic acid and citric acid, and the nutritional agent comprises collagen peptide.
Example 3:
1) stirring and mixing 0.4% of pumpkin pectin, 1.2% of edible quillaja saponin, 1% of compound vitamin and 2.5% of synergist by weight, and mixing the mixture for later use;
2) blending 40% of ionized calcium and 10% of drinking water by weight to obtain mixed liquid;
3) mixing 2% of edible organic acid and 18% of blending agent by weight, then adding the mixture obtained in the step 1) and the mixed liquid obtained in the step 2) into the mixture at the same time, and stirring to obtain the traditional Chinese medicine preparation containing ionized calcium with improved drug effect.
The pumpkin pectin in the step 1) is heated to 35-40 ℃ for use.
The synergist is tabasheer, the blending agent is grape juice or grapefruit juice, the edible organic acid comprises malic acid and citric acid, and the nutritional agent comprises collagen peptide.
The ionic calcium-containing Chinese medicinal preparation prepared in example 3 was used in the following experiments
The method comprises the following steps of stirring 500 ml of water and 20 g of medlar in a control group for 2 minutes, boiling for 1 hour, fishing out the medlar, concentrating the boiled medlar water into 100 ml of medlar water, taking 100 ml of the traditional Chinese medicine preparation containing ionized calcium prepared in the embodiment 3 in the test group, adding 20 g of medlar, stirring for 2 minutes, fishing out the medlar, and then measuring the content of effective components of the medlar in the control group and the test group respectively, wherein the content of the effective components of the medlar in the control group is 5 times of the content of the effective components of the medlar in the test group.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (9)
3. the pharmaceutical composition of claim 1 or 2, comprising ionized calcium for enhancing therapeutic effect, wherein: the synergist is concretio silicea Bambusae seu Schizostachyi.
4. The pharmaceutical composition of claim 1 or 2, comprising ionized calcium for enhancing therapeutic effect, wherein: the blending agent is grape juice or grapefruit juice.
5. The pharmaceutical composition of claim 1 or 2, comprising ionized calcium for enhancing therapeutic effect, wherein: the edible organic acid comprises malic acid and citric acid.
6. The pharmaceutical composition of claim 1 or 2, comprising ionized calcium for enhancing therapeutic effect, wherein: the nutritional agent includes collagen peptides.
7. A method for preparing the pharmaceutical preparation of claim 1 or 2, comprising ionized calcium for improving the efficacy, comprising the steps of:
1) stirring and mixing 0.2-0.6% by weight of pumpkin pectin, 0.8-2% by weight of edible quillaja saponin, 0.5-2% by weight of multivitamin and 2-3% by weight of synergist, and mixing the mixture for later use;
2) blending 30-45% of ionized calcium and 5-15% of drinking water by weight to obtain a mixed liquid;
3) mixing 1-3% of edible organic acid and 12-22% of blending agent by weight, adding the mixture obtained in the step 1) and the mixed liquid obtained in the step 2) into the mixture, and stirring to obtain the traditional Chinese medicine preparation containing ionized calcium with improved drug effect.
8. The method for preparing the pharmaceutical preparation of claim 7, which comprises ionized calcium for improving the therapeutic effect, wherein the pharmaceutical preparation comprises the following steps: the pumpkin pectin in the step 1) is heated to 35-40 ℃ for use.
9. The method for preparing the pharmaceutical preparation of claim 7, which comprises ionized calcium for improving the therapeutic effect, wherein the pharmaceutical preparation comprises the following steps: the synergist is tabasheer, the blending agent is grape juice or grapefruit juice, the edible organic acid comprises malic acid and citric acid, and the nutritional agent comprises collagen peptide.
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Application publication date: 20200717 |