CN107349227A - A kind of new medicine concocting method - Google Patents
A kind of new medicine concocting method Download PDFInfo
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- CN107349227A CN107349227A CN201610304845.9A CN201610304845A CN107349227A CN 107349227 A CN107349227 A CN 107349227A CN 201610304845 A CN201610304845 A CN 201610304845A CN 107349227 A CN107349227 A CN 107349227A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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Abstract
The present invention disclose a kind of new medicine concocting method, soaks Chinese medicine using calcium base solion, the calcium base solion refers to containing the solution that calcium ion mass percent concentration is 0.5% 6%.The advantage of the invention is that：Calcium base solion has to the more preferable penetrability of cell, therefore, the Chinese medicine processed with calcium base solion has more preferable transdermally to act on, solves the problems, such as traditional Chinese medicine external application transdermally effect difference.Compatibility Chinese medicine is processed by calcium base solion, external application transdermally, can be directed to affected part Partial Perimeter nerve has the function that to slow down or suppress neuropathic pain, can treat the symptoms such as human nerve shouting pain.This technology can reach therapeutic effect with the administering mode of changing section traditional Chinese medicine for oral administration (decoction, patent medicine) by external application, avoid taking stimulation, the damage of liver kidney of the Chinese medicine to stomach, play the effect of inner disease outer treat.
Description
Technical field
The invention belongs to Chinese medicine preparation field, more particularly, is related to a kind of new medicine concocting method.
Background technology
The effect of quality of Chinese medicine preparation quality directly affects medicine therapy, China's successive dynasties name doctor attach great importance to
Chinese medicine preparation method.Han dynasty doctor Zhang Zhongjing by decoction with moisture be rainwater, thousand pump up water etc. it is a variety of；Xu Ling tires
Think：" method boiled medicine, most preferably deep to say, whether the effect of medicine or not, lies in this entirely "；Li Shizhen (1518-1593 A.D.) indicates that decoction is decocted
Boil improperly adverse consequences：" it is all to take decoction of medicinal ingredients, though product thing is specially smart, repair and renovate such as method, and the person's of boiling medicine crudity is hurried,
Extreme misery is bad, and duration and degree of heating mistake degree, then medicine is also idle." these all illustrate that ancients have recognized that processing (decoction) mistake
There are factors to influence concocted quality in journey, and the quality of concocted quality directly affects the performance of herbal medicine efficacy.
Two kinds of changes to occur during Chinese medicine preparation：First, the dissolution of medicament effective component；Second, in medicine
Various physiologically active compositions carry out combination reaction.Therefore, the concocting method of decoction has many special be particular about.
Immersion is to process that Chinese medicine is important and the key link, before the prepared slices of Chinese crude drugs are decocted immersion not only improve effectively into
Being fully dissolved out for part, can shorten decocting time, avoid, because decocting time is long, causing part effective ingredient again
Consume, destroy excessively.Most medicines preferably use cold water soak, and medicine is poured into medicine pot and shakeout, then plus normal
Warm water -- room temperature water soaks 60 minutes, about 2 centimetres of the high drug plane of water during light pressing material.It is impregnated with medicinal material for original
Then.Summer temperature is high, and soak time is unsuitable long, in order to avoid putrid and deteriorated, winter can be grown.Especially need
It should be noted that immersion Chinese medicine can not definitely be soaked with boiling water.
In traditional Chinese medicine concocting process, the selection for immersion water also has a set of rule sanctified by usage, i.e.,
Boil medicine or the necessary free from extraneous odour of immersion water, cleaning are clarified, it is few containing mineral matter and impurity.In general, ordinary person
The water that can make to drink on the living conditions can be adopted to decocting herb.Be generally available limpid spring, river and from
Water, well water must then select water quality preferable.Traditional concept thinks that water is preferably with by purifying and softening
Drinking water, be mixed into reducing impurity, prevent calcium in water, magnesium plasma and medicinal material composition from precipitation reaction occurs.
Under the influence of this traditional concept, immersion water typically all can the relatively single running water of selection component
Or pure water, almost use the aqueous solution rich in mineral matter without selection.
The content of the invention
It is an object of the invention to provide a kind of new medicine concocting method.
To realize object above, the present invention discloses following technical scheme：A kind of new medicine concocting method, makes
Chinese medicine is soaked with calcium base solion, the calcium base solion refers to containing calcium ion mass percent concentration
For 0.5%-6% solution.
As a preferred scheme, the calcium base solion is soaked in dilute hydrochloric acid solution by shell and obtained.
As a preferred scheme, the shell is soaked in dilute hydrochloric acid solution after crushing.
As a preferred scheme, the shell refers to oyster, clam shell, pearl, the shell of seaear, sea clam, text
One or more in clam, clam, big clam, Che Qu, purple shellfish, river snail, snail spiral shell.
As a preferred scheme, the Chinese medicine is treatment on nti-freckle, pouch of dispelling, skin-whitening, anticreep
Generation lotion, anti-dandruff surfactant, gout, leucoderma, eczema, psoriasis, pruitus, arthritis
And retrogression pathological changes, foot clearing damp, tinea pedis, foot degrading the channel, female mammary gland proliferation, striae of pregnancy, male
Sexual function, precedent adenositis, the Chinese medicine of cutaneum carcinoma.
The advantage of the invention is that：Calcium base solion has to the more preferable penetrability of cell, therefore, with
The Chinese medicine that calcium base solion processes has more preferable transdermally to act on, and it is poor to solve traditional Chinese medicine external application transdermally effect
The problem of.Compatibility Chinese medicine is processed by calcium base solion, external application transdermally, affected part Partial Perimeter god can be directed to
Through having the function that to slow down or suppress neuropathic pain, the symptoms such as human nerve shouting pain can be treated.This skill
Art can reach treatment effect with the administering mode of changing section traditional Chinese medicine for oral administration (decoction, patent medicine) by external application
Fruit, avoid taking stimulation, the damage of liver kidney of the Chinese medicine to stomach, play the effect of inner disease outer treat.
Brief description of the drawings
Each ion concentration test result in the calcium base solion that Fig. 1 extraction pearls obtain.
Embodiment
With reference to specific embodiment, the present invention is expanded on further.Experiment side used in following embodiments
Method is conventional method unless otherwise specified.Material used, reagent etc. in following embodiments, such as without spy
Different explanation, is commercially obtained.It should be understood that these embodiments are merely to illustrate the present invention and not had to
In limitation the scope of the present invention.
(1) summarize：Calcium base solion used in this technology is that a kind of extracted from shell " has
Machine hydrophilic ionic-liquid " (ionic liquid effect that different shells is obtained by extraction is variant), processing container
There are lid vessel to be nonmetallic.
1. the specified calcium content using in liquid of the calcium base solion of this technology measures as ionic liquid diluted concentration
Standard value (stoste calcium content is 20%).Example：Water is 1 with finished product organic ion stoste proportion：1.275/ml
When, calcium content is 20% (extreme value).When+3 parts of pure water dilutions of 1 part of ion stoste, ionic liquid calcium content
For 5%.Calculate required dilution ionic liquid concentration with proportion mode.
2. calcium base solion is diluted to, 0.5%-6% is stand-by, for different illnesss, purposes, its calcic
Amount threshold value is also not quite similar.
(2) the processing program and purposes of decoction
A. before medicinal herb soak, processing early stage need to be carried out.
1. being cleaned before immersion with 45 ° of -60 ° of edible distillate spirits, floating dust, impurity are removed.
2. prevent to be cleaned with water.Mould can be produced in concocting process after herbal medicine water suction.
B. calcium base solion is diluted to required concentration with pure water, fully stirs evenly and processed.(calcium base
For solion concentration as being less than 3.5%, decoction is not easy to maintain, can produce and go mouldy.)
C. when calcium base solion concentration be less than 3.5% when, it is impossible to processed with pure water, can use 3.5%-
0.5% calcium base solion is processed with 45 ° of -60 ° of edible distillate spirits as dilution.
For the illness of patient, different Chinese medicine preparations is selected.By drug immersion certain concentration calcium base from
In sub- solution.After maturation is processed, decoction is applied to affected part.It is recommended that daily one to secondary, it is appropriate every time.
Being excessively used to skin has the generation of calcification phenomenon, can recover normal in two weeks after deactivation.
This technology is mainly for diseases such as all kinds of skin disorders, arthralgia, muscle cramp, neuropathic pains
Shape.There is obvious effect to involved scope (conditioning liquid is tried out).
Contrast test：
Case：Contrasted with the liquid of this technology processing liquid brewed with alcohol：Select same patient, phase
Under the conditions of same dose, the left and right leg gonitis of patient is locally smeared respectively, once a day, every time
2ml, comparative result after ten days, this technology positive effect.
Points for attention：Allergic constitution patient uses with caution.
(3) ionic liquid suppresses the mechanism of neuropathic pain
Na in ionic liquid+K+The potential difference of nerve fibre is had an impact and acted on：
Sodium-potassium pump：Sodium-potassium pump is really a kind of Na on cell membrane+-K+ATP enzyme.Intracellular sodium from
Son can be combined with the enzyme, and be transported outside film, therewith be transported to potassium ion in film outside film.It is this it is outer it is negative in just
Current potential be referred to as action potential.Action potential is excited main forms.
Nerve fibre is in quiescent condition, K+Outflow, the distribution of charges situation inside and outside cell membrane is：It is outer just interior
It is negative.When nerve fibre excitatory state, Na+Interior stream, intercellular membrane current potential be changed into it is outer it is negative in just.Into the cell
Membrane potential difference can change the voltage door on nerve fibre, control Na+Internal flow channel, it is blocked conduction, from
And reach a kind for the treatment of method for the purpose for suppressing neuropathic pain.
(4) this ionic liquid is the method obtained from shell by chemically reacting
CaCO3+ 2HCl=CaCl2+H2O+CO2↑ (+fourth liquid)
Principle：Calcium carbonate and hydrochloric acid reaction generation calcium chloride, carbon dioxide and water, by the calcium carbonate of solid
It is transformed into liquid calcium chloride solution.(this solution contains following composition after testing：Na+、Ca2+、Mg2+、K+、
Cl-, Br, S and protein).By shell gene program self-assembling formation different kinds of ions solution, we term it
" calcium base solion ".
When technological process is matched somebody with somebody in summary:
A.1Kg it is molten to be dipped in 6000ml watery hydrochloric acid for shell → cleaning, dry up, be crushed to 3-5mm blocks →
(concentration of hydrochloric acid solution is less than 3.5%) → rotation chemical reaction system → ionic liquid (early-products) in liquid.
B. it is (former to reach 20% concentration for ionic liquid early-products → tri- negative pressure filtrations → spraying destructive distillation → calcium ion
Liquid) → store for future use.
Note：Whole process is all operated in nonmetallic vessel and non-metallic conduit.
The calcium base solion that this technology uses be obtain organism shell in organic matter and inorganic matter it is whole
Its effect of the combination of body is more more perfect than single ion compatibility effect.
Extract each ion concentration test result such as Fig. 1 in the calcium base solion that pearl obtains.
Shell smell is classified：(select from《Compendium of Materia Medica》,【Cure mainly】See related original text).
(1) oyster：【Smell】It is salty, put down, be slightly cold, be nontoxic.Fritillaria to make, obtain radix glycyrrhizae, the root of bidentate achyranthes,
Polygala, frutus cnidii are good, dislike Chinese ephedra, the flower bud of lily magnolia, evodia rutaecarpa, volt chimney sand.
(2) clam shell：【Smell】It is salty, cold, nontoxic.
(3) pearl：【Smell】It is salty, sweet, cold, nontoxic.
(4) shell of seaear：【Smell】It is salty, flat, nontoxic.
(5) sea clam：【Smell】It is bitter, salty, flat, nontoxic.
(6) clam：【Smell】It is salty, flat, nontoxic.
(7) clam：【Smell】It is salty, cold, nontoxic.
(8) big clam：【Smell】It is sweet, salty, flat, nontoxic.
(9) car canal：【Smell】It is sweet, salty, Great Cold, nontoxic.
(10) purple shellfish：【Smell】It is salty, flat, nontoxic.
(11) river snail：【Smell】It is sweet, flat, nontoxic.
(12) snail spiral shell：【Smell】It is sweet, cold, nontoxic.
The joint conditioning liquid of embodiment 1.
1. Chinese herbal medicine：Windproof 75g roots of bidentate achyranthes 120g roots of Dahurain angelica 50g Radix Angelicae Sinensis 20g radix glycyrrhizaes 60g.
2. ionic liquid is prepared：1000ml, ion stoste 250ml, pure water 750ml.
3. concocting method：Whole Chinese herbal medicines are immersed to seal in 1000ml ionic liquids simultaneously and processed.Time is
3-5 days.Filtered by filter paper, ripe conditioning liquid is brown transparency liquid, there is nature herbal medicine fragrance.
In Clinical practice, multiple patients with long-term paint joint disease, what is obtained using this concocting method
After conditioning liquid, symptom substantially mitigates.Such as 60 years old certain male patient (for the protection of patients' privacy,
Its underground name, similarly hereinafter), knee pain 3 years, squat down on the ground over time, knee joint part during standing
There is " rub-a-dub rub-a-dub rub-a-dub " sound position, is not improved using conventional therapy arthralgia Chinese medicine, same Chinese medicine is matched somebody with somebody
Fang Gaiwei is with reusing after this concocting method, positive effect after 4 weeks, and " rub-a-dub rub-a-dub rub-a-dub " sound disappears, closed
Section no longer pain.55 years old certain female patient for another example, knee pain 5 years, uses conventional therapy joint
Pain Chinese medicine is not improved, and same Chinese medicine preparation is changed to reusing after this concocting method, 3 weeks it
Positive effect afterwards, pain relief, or even climb the mountain and ascend a height and can be readily implemented.Also 78 years old certain women suffers from
Person, knee pain 12 years, it is not improved using conventional therapy arthralgia Chinese medicine, same Chinese medicine is matched somebody with somebody
Fang Gaiwei positive effect after 6 weeks, is not ached on foot with being reused after this concocting method.
The psoriasis conditioning liquid of embodiment 2.
1. Chinese herbal medicine：(dispensing information：This Chinese herbal medicine formula is selected from《Hundred careless good recipes》, control a wind cutting sore, skin
Skin itch, scratch into urticaria), windproof (going to pitch), cicada shell, pig bud Chinese honey locust (shortcake is processed, removed the peel, son) each one
Two halves, two liang of rhizoma Gastrodiae.
2. ionic liquid is prepared：1000ml, ion stoste 250ml, pure water 750ml.
Such as 62 years old certain female patient, ox-hide moss for many years, uses conventional therapy ox-hide moss at face's eyebrow
Chinese medicine be not improved, same Chinese medicine preparation is changed to reusing after this concocting method, after 3 weeks
Positive effect.
The pruitus conditioning liquid of embodiment 3.
1. Chinese herbal medicine:Fruit of summer cypress 150g favus skins 100g.
2. ionic liquid is prepared：1000ml, ion stoste 200ml, pure water 800ml.
For example 45 years old certain male patient, skin of abdomen itch for many years, use conventional therapy pruitus
Chinese medicine is not improved, and same Chinese medicine preparation is changed to be reused afterwards with this concocting method, the aftereffect of 2 weeks
Fruit is obvious.
The hair tonic conditioning liquid of embodiment 4.
1. Chinese herbal medicine：Oriental wormwood 100g winter creeper 60g safflower 5g gingers 100g.
2. ionic liquid is prepared：700ml, ionic liquid：(oyster stoste) 50ml, white wine (52 degree) 650ml.
Such as 58 years old certain male patient, for many years, the Chinese medicine nursing liquid sent out using conventional growth-promoting is without bright for alopecia
Aobvious to improve, same Chinese medicine preparation is changed to be reused afterwards with this concocting method, positive effect after 3 weeks,
Gradually hair is grown in place of alopecia.
Described above is only the preferred embodiment of the present invention, it is noted that for the common of the art
Technical staff, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these
Improvements and modifications also should be regarded as protection scope of the present invention.
Claims (5)
1. a kind of new medicine concocting method, it is characterised in that soak Chinese medicine, institute using calcium base solion
Calcium base solion is stated to refer to containing the solution that calcium ion mass percent concentration is 0.5%-6%.
A kind of 2. new medicine concocting method according to claim 1, it is characterised in that the calcium base
Solion is soaked in dilute hydrochloric acid solution by shell and obtained.
A kind of 3. new medicine concocting method according to claim 2, it is characterised in that the shell
Dilute hydrochloric acid solution is soaked in after crushing.
4. a kind of new medicine concocting method according to Claims 2 or 3, it is characterised in that described
Shell refer to oyster, clam shell, pearl, the shell of seaear, sea clam, clam, clam, big clam, Che Qu,
One or more in purple shellfish, river snail, snail spiral shell.
A kind of 5. new medicine concocting method according to claim 1, it is characterised in that the Chinese medicine
For treatment on nti-freckle, pouch of dispelling, skin-whitening, preventing baldness liquid, anti-dandruff surfactant,
Gout, leucoderma, eczema, psoriasis, pruitus, arthritis and retrogression pathological changes, foot
Clearing damp, tinea pedis, foot degrading the channel, female mammary gland proliferation, striae of pregnancy, male's sexual, precedent
The Chinese medicine of adenositis, cutaneum carcinoma.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019024112A1 (en) * | 2017-08-04 | 2019-02-07 | 赵建国 | Method for processing traditional chinese medicine using calcium-based ion solution and application thereof |
| CN111420063A (en) * | 2020-03-31 | 2020-07-17 | 石林道商生物科技有限公司 | A Chinese medicinal preparation containing ionized calcium for improving drug effect, and its preparation method |
| CN111840473A (en) * | 2020-08-25 | 2020-10-30 | 葛鑫海 | Traditional Chinese medicine bamboo pot and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2020529474A (en) * | 2017-08-04 | 2020-10-08 | 趙建国 | Method of processing Chinese herbs using calcium-based ion solution and its use |
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| CN111420063A (en) * | 2020-03-31 | 2020-07-17 | 石林道商生物科技有限公司 | A Chinese medicinal preparation containing ionized calcium for improving drug effect, and its preparation method |
| CN111840473A (en) * | 2020-08-25 | 2020-10-30 | 葛鑫海 | Traditional Chinese medicine bamboo pot and preparation method thereof |
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