CN1112012A - Biological oral liquid - Google Patents
Biological oral liquid Download PDFInfo
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- CN1112012A CN1112012A CN 95102084 CN95102084A CN1112012A CN 1112012 A CN1112012 A CN 1112012A CN 95102084 CN95102084 CN 95102084 CN 95102084 A CN95102084 A CN 95102084A CN 1112012 A CN1112012 A CN 1112012A
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Abstract
The biological oral liquid for improving immunity, suppressing tumor and bacteria, increasing functions of liver, kidney, stomach and intestine, and curing neurasthenia with obvious effect contains tonic Chinese-medicinal components such as astragalus root, ginseng, pilose asiabell root, siberian solomonseal rhizome, honey, etc. and useful living bacteria such as lactobacillus, difidobacteria, etc.
Description
The present invention relates to a kind of biological oral liquid.
The therapy current, that international medical community is being widely current a kind of " antibacterial with bacterium " is thought because body is subjected to the interference of external environment, makes the interior normal flora imbalance of body and causes human body diseases, coordinates so should keep the human body normal flora.Many biological oral liquids have appearred in theory according to this, reach " SANZHU KOUFUYE " etc. as " TAIYANGSHEN hericium koufuye " on the Chinese market.
China's traditional medicine thinks that Chinese medicine has tangible immunologic function and antitumor action to human body, can not be ignored.And simple biological oral liquid does not have the unique effect of Chinese medicine.
Task of the present invention is to develop that a kind of Chinese medicine and pharmacy that China is traditional and " antibacterial with bacterium " theory combine is the biological oral liquid of culture medium with Chinese medicine.
Task of the present invention is finished like this: developed a kind of active bacteria formulation that comprises the plurality of Chinese composition, not only contained useful viable bacteria, also contained tonification Chinese medicine.
Useful viable bacteria in the biological oral liquid of the present invention can be the strain in the Lactobacillus, also can be the strain in the Bifidobacterium, also can be other useful viable bacteria.Contained tonification Chinese medicine is a kind of in the Radix Astragali, Radix Ginseng, Radix Codonopsis, Rhizoma Polygonati, Mel, Fructus Jujubae, Pericarpium Citri Reticulatae, Fructus Crataegi, Placenta Hominis, Fructus Lycii, Fructus Ligustri Lucidi and the Radix Ophiopogonis or several or all in the oral liquid, also can be other Chinese medicine with close effect.
Through experiment, the optimum formula of biological oral liquid of the present invention is: contain the Radix Astragali 205～235 grams in per 10,000 milliliters of oral liquids, Radix Ginseng 8～12 grams, Radix Codonopsis 87～147 grams, Rhizoma Polygonati 175～205 grams, Mel 580～630 grams, Fructus Jujubae 580～630 grams, Pericarpium Citri Reticulatae 100～140 grams, Fructus Crataegi 102～132 grams, Placenta Hominis 230～250 grams, Fructus Lycii 210～250 grams, Fructus Ligustri Lucidi 175～195 grams, Radix Ophiopogonis 175～200 grams, lactobacillus 10
7～10
11Individual, bacillus bifidus 10
7～10
11Individual.
The Chinese medicine preparation of biological oral liquid of the present invention is resolved as follows:
This prescription is a monarch drug with Radix Ginseng, Radix Codonopsis, the Radix Astragali, Rhizoma Polygonati, and reuses the Radix Astragali, with vigorate qi and replenish the blood, and vital base and primordial QI consolidating, the five internal organs that are in harmonious proportion are this.The Radix Astragali is gone into the lung QI invigorating, goes into that table is real to be defended, for all medicines of QI invigorating.Associate with Rhizoma Polygonati, its effect is better.Radix Codonopsis power can spleen reinforcing nourishing the stomach, the lung moistening and production of body fluid promoting, gas in the strong fortune, spleen invigorating fortune and not dry is grown stomach and wet.Normal and Radix Ginseng is shared.
This prescription with YIN-tonifying drug such as Placenta Hominis, Fructus Lycii, Fructus Ligustri Lucidi, Radix Ophiopogonis be minister auxilliary it, have vital essence replenishing, promote the production of body fluid and effect such as moisturize.Wherein, Placenta Hominis, Fructus Lycii, Fructus Ligustri Lucidi the liver and the kidney tonifying, YIN nourishing replenishing essence are applicable to soreness of waist and knee joint, disease such as puckery dim-sighted, dizzy, vexed, the hectic fever of feverish sensation in the palms and soles, order, night sweat.Radix Ophiopogonis sweetness and bitterness is slightly cold, and goes into lung heart stomach warp, has that tonifying the lung the moon, lung moistening are dry, nourishing stomach-YIN, promoting the production of body fluid to quench thirst, effect tired, that end insomnia clears away heart-fire.
This prescription adjuvant has Pericarpium Citri Reticulatae, Fructus Crataegi, Mel, Fructus Jujubae.QI invigorating such as ginseng stilbene etc. is built up one's health by taking tonic and do not stop up dampness and dispel turbidly, control gastral cavity painful abdominal mass abdominal distention, indigestion and loss of appetite loose stool due to the turbid damp obstructing in middle-JIAO; Relieving dyspepsia, help spleen appetizing, facilitating digestion, can go into blood system again, the promoting blood circulation to remove blood stasis detumescence.
The effect of each component is as follows in the biological oral liquid of the present invention:
Radix Astragali sweet in the mouth tepor, energy tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration.Modern study proves: the Radix Astragali has immunological enhancement.The Radix Astragali strengthens the phagocytic function of reticuloendothelial system significantly.The effect of inducement interferon is all arranged in animal and human's body.The chronic active hepatitis of pair cell immunologic hypofunction and chronic persistent hepatitis patient can strengthen cellular immunization, improve liver function.
The ginseng polysaccharide can make tumor-bearing mice body raise immunity.Low dose of Radix Ginseng strengthens the phagocytosis of reticuloendothelial cell.Radix Ginseng promotes lymphocyte transformation to the generation of laboratory animal energy enhancing antibody and complement, and slight anti-tumor effect is arranged.
Radix Codonopsis can strengthen the phagocytic function of reticuloendothelial system, and Radix Codonopsis extract obviously increases Turnover of Mouse Peritoneal Macrophages quantity, and volume increases, and pseudopodium increases, and endochylema inner room bubble increases, and presents the cell phenomenon that is activated.
Rhizoma Polygonati extract can significantly increase the T cell percentage, strengthens its immunologic function.
Mel is survived lactobacillus.
The Pericarpium Citri Reticulatae injection all has certain facilitation to immunity, cellular immunization in the body.
Fructus Crataegi has heart tonifying, blood vessel dilating, resists myocardial ischemia, blood fat reducing, prevent and treat atherosclerosis, and facilitating digestion and antiplatelet aggregative activity are a kind of rising life lengthening health care medicines.The Fructus Crataegi injection can significantly strengthen rabbit humoral immunization and cellular immune function.
Placenta Hominis promotes that Wbc quantity increases in the blood, strengthens cytophagous effect, the human body immunity improving function.
The Fructus Lycii polysaccharide can be worked in coordination with chemotherapy, obviously suppresses S180 tumor-bearing mice growth of tumor and improves its immunologic function.
No matter external experiment in Fructus Ligustri Lucidi or the body all have the raise immunity effect, especially remarkable to the lymphopoietic facilitation of normal person.
Radix Ophiopogonis contains total Saponin, and intravenous injection can effectively prevent or resist by CHC13-Adr, the arrhythmia that BAC12-Aco brought out, and make 24 hours ventricular arrhythmia incidence rate of ligation dog coronary artery reduce to 57 ± 7% by 87 ± 8%.
Lactobacillus can decompose saccharide compound at the enteral of human body, produces lactic acid, and intestinal acidity is increased, thereby suppresses the breeding of intestinal pathogenic bacteria, prevents that protein from decomposing, and is used for the treatment of dyspepsia, infantile diarrhea etc.
The effect of lactobacillus and bacillus bifidus shows as:
1. keep the normal configuration and the function of host tissue organ.
2. adhering to and breeding at host's skin, mucomembranous surface specific part, form one deck nature Mycoderma, is nonspecific localised protection film, can make body exempt from the invasion of pathogenic bacterium and troop.
3. it has the nonspecific immunity effect.
4. synthetic vitamin.
5. antagonism is attacked the effect of flora outward.
6. normal flora influences the absorption of host to sugar, protein, fat and vitamin.
The preparation method of biological oral liquid of the present invention:
Press formula ratio with Radix Ginseng, the Radix Astragali, Fructus Lycii, Fructus Ligustri Lucidi, Rhizoma Polygonati, Radix Codonopsis, Fructus Crataegi, Radix Ophiopogonis, Pericarpium Citri Reticulatae, Fructus Jujubae,, decoct half an hour, filter, discard filtering residue with 4～6 times of water gagings.Merging filtrate, stand-by.Placenta Hominis was steeped two days with 3 times of water gagings, blend and decoct with water filtration, two kinds of filtrates are merged, add the Mel refining to 10,000 milliliters by formula ratio, behind high temperature sterilize, inoculating lactobacillus and bacillus bifidus were in 28～30 ℃ of fermentations 5 hours, after the assay was approved, packing, sealing is promptly.
The discriminating of biological oral liquid of the present invention:
1, the affirmation of lactobacillus existence: this product is a lactobacillus preparation, so adopt the authentication method (ministry standard, version in 1963,71 pages) of lactasinum.
2, the affirmation of flavonoid glycoside: Fructus Crataegi, Pericarpium Citri Reticulatae, the Radix Astragali it is reported and all contain the flavonoid glycosides composition in this prescription, and Radix Ginseng and Radix Ophiopogonis also contain a small amount of flavonoid glycosides composition.Flavonoid glycoside has the feature differential method, so can adopt the existence of checking flavonoid glycoside to confirm this product:
1. chromogenic reaction: get 10 milliliters of this product, behind ether defatting, use n-butanol extraction.Extracting solution is flung to n-butyl alcohol, and the residue dissolve with ethanol filters.Get 1 milliliter of filtrate, add magnesium powder a little, 2～3 of dripping hydrochloric acid should show cherry red.
2. thin layer chromatography: get 10 milliliters of this product, behind ether defatting, use n-butanol extraction, extract is flung to n-butyl alcohol, and residue is made sample liquid with dissolve with methanol; Other gets Fructus Crataegi, Pericarpium Citri Reticulatae, each 0.5 gram of the Radix Astragali, adds the methanol soaked overnight, filters, concentrates, and is mixed with control medicinal material solution; Get the rutin standard substance and be mixed with the reference substance solution of 0.1mg/10ml with methanol, according to thin layer chromatography test (Chinese Pharmacopoeia, 57 pages of appendix of nineteen ninety version), drawing above-mentioned three kinds of solution each a little (10 μ l) puts respectively on same silica gel g thin-layer plate, with ethyl acetate: methanol: water=10: 2: 3.1 is that spreader launches, take out, dry, with 1% aluminum chloride methanol solution spraying colour developing, under ultra-violet lamp (365nm), inspect, with the corresponding position of control medicinal material chromatograph on, should show the fluorescence speckle of same color, with the corresponding position of reference substance chromatograph on, should show an identical glassy yellow speckle.
The purposes of biological oral liquid of the present invention:
Can regulate gastrointestinal and body function, the enhancing human body immunity ability, aid digestion.Be used for dyspepsia, appetite is poor, the various hypofunctions of person in middle and old age, diseases such as neurasthenia.Also can make the ancillary drug of cancer chemotherapy radiotherapy.Usage: oral, each 10～20 milliliters of usual amounts, every day 2～3 times.
Studied of the influence of this biological oral liquid by experiment to mouse cell immunity and humoral immune function:
1, this biological oral liquid is to normally reaching the influence of the antibody-producting cell (PFC) of mice with radiation injury: the result shows that medicine can strengthen normal mouse produces antibody to thymus-dependent antigen (SRBC) ability.Increase immune function of mice with drug dose and strengthen, with matched group than P＜0.001.Medicine can promote the recovery of mice with radiation injury humoral immune function equally, radiation back medication 30 days and 45 days, the antibody-producting cell number (PFC) of mice shows that apparently higher than matched group P＜0.001 this medicine can obviously promote the recovery of mice with radiation injury humoral immune function.Prolongation facilitation along with administration time has the trend that increases progressively simultaneously.
2, this biological oral liquid can strengthen and promote the splenocyte breeder reaction effect of normal and mice with radiation injury.The result shows normal mice medication 10 days and mice with radiation injury medication 30 days, 45 days, and mouse boosting cell breeder reaction (CPM value) all is higher than matched group P＜0.0001
Illustrate that medicine can not only strengthen normal mice T cell and B cell to the mitogen respond, and can promote the T of mice with radiation injury and B cell that the mitogen respond is comparatively fast recovered.
3, this biological oral liquid promotes normal and mice with radiation injury DTH respond.Normal and mice with radiation injury is distinguished medication after 10 days and 45 days, and the DTH reaction all is higher than corresponding matched group DTH reaction, P＜0.01 and P＜0.05.Illustrate that this medicine has obvious effect to the cellular immune function that strengthens normal and mice with radiation injury.
The radiosensitivity of immunity lymphocyte and lymphoid cell is closely related with the influence of radioactivity cellular function, by the radiation injury Research of Animal Model for Study this biological oral liquid to normal and mice with radiation injury Immune Effects, illustrate that this medicine has tangible enhancing and facilitation to the cell and the humoral immune function of body, point out this medical instrument that anti-putting and immune-enhancing effect arranged.
By three hospitals to the 100 routine clinical observations of this biological oral liquid, obvious effective rate 70%, effective percentage 22%, inefficiency 8%, total effective rate 92%; Matched group clothes TAIYANGSHEN hericium koufuye, obvious effective rate 46%, effective percentage 32%, inefficiency 22%, total effective rate 78%.There is significant difference P＜0.01.The result shows: this product has replenishing QI to invigorate the spleen, nourishing the liver and kidney, the effect of nourishing blood to tranquillize the mind.Be applicable to physical weakness, dyspepsia, and the patient who causes immunologic hypofunction after the oncosis radiotherapy, chemotherapy, dizzy to the deficiency of vital energy, blood deficiency, QI and blood deficiency caused especially, insomnia, cardiopalmus are breathed hard inappetence, diseases such as tiredness with no desire to speak have curative effect preferably, and total effective rate reaches 92%.Observation shows:
1, anemia is also had better therapeutic effect, it can increase erythrocyte, hemoglobin and platelet.From 100 routine observation situations: patient's erythrocyte of 77% all has rising in various degree; 82% patient blood hemoglobin has increasing in various degree; Patient's platelet count of 69% has raising.Prove absolutely the anemia of this product due to can the non-leukemia of application of treatment.
2, neurasthenia, chronic the spleen-stomach disease there is the obvious treatment effect.
3, can raise immunity, 93% patient IgG has raising in various degree; 86.66% patient IgA has raising in various degree; 83.33% patient IgM increases.
4, treatment coronary heart disease, myocarditis also have certain curative effect, by benefiting QI and nourishing blood, can improve coronary circulation.From 34 routine coronary heart disease, myocarditis and other ARR electrocardiogram, 64.7% patient's coronary blood supply and arrhythmia improve.
Show by above animal experiment and clinical research: this oral liquid reach based on fill blood, the purpose of YIN nourishing kidney, wait the resistance against diseases that improves human body with spleen invigorating, the digestion that participates in the human body nutrient substance and absorption, elimination endotoxin, the imbalance of treatment thalline, this oral liquid has the human body of adjusting function equilibrium, recover cellular immune function, anti-epidemic disease and immune-enhancing effect are arranged, suppress the effect of tumor and pathogenic bacterium, improve liver, kidney, stomach, intestinal function to adjusting, resisting fatigue, the treatment neurasthenia waits remarkable efficacy, and has anti-cancer, antitumaous effect.
Embodiment 1:
In 10,000 milliliters of oral liquids, contain the Radix Astragali 220 grams, Radix Ginseng 10 grams, Radix Codonopsis 117 grams, Rhizoma Polygonati 175 grams, Mel 580 grams, Fructus Jujubae 580 grams, Pericarpium Citri Reticulatae 120 grams, Fructus Crataegi 117 grams, Placenta Hominis 230 grams, Fructus Lycii 230 grams, Fructus Ligustri Lucidi 175 grams, Radix Ophiopogonis 175 grams, Bulgarian Lactobacillus 10
9Individual, the Lactobacillus acidophilus 10
9Individual, bacillus bifidus 10
9Individual.
Embodiment 2:
In 10,000 milliliters of oral liquids, contain the Radix Astragali 205 grams, Radix Ginseng 8 grams, Radix Codonopsis 87 grams, Rhizoma Polygonati 190 grams, Mel 605 grams, Fructus Jujubae 605 grams, Pericarpium Citri Reticulatae 100 grams, Fructus Crataegi 102 grams, Placenta Hominis 240 grams, Fructus Lycii 210 grams, Fructus Ligustri Lucidi 185 grams, Radix Ophiopogonis 183 grams, the Lactobacillus acidophilus 10
7Individual, bacillus bifidus 10
7Individual.
Embodiment 3:
In 10,000 milliliters of oral liquids, the Radix Astragali 235 grams, Radix Ginseng 12 grams, Radix Codonopsis 147 grams, Rhizoma Polygonati 205 grams, Mel 630 grams, Fructus Jujubae 630 grams, Pericarpium Citri Reticulatae 140 grams, Fructus Crataegi 132 grams, Placenta Hominis 250 grams, Fructus Lycii 250 grams, Fructus Ligustri Lucidi 195 grams, Radix Ophiopogonis 200 grams, Bulgarian Lactobacillus 10
11Individual, bacillus bifidus 10
11Individual.
Embodiment 4:
Contain the Radix Astragali in the oral liquid, Radix Ginseng, Rhizoma Polygonati, Fructus Lycii, aminoacid, vitamin and bacillus bifidus, bacillus bifidus content are every milliliter 100,000,000.
Embodiment 5:
Contain the Radix Astragali in the oral liquid, Mel, glucose, protein, vitamin, lactobacillus, bacillus bifidus and enterococcus, three kinds of bacterium total contents are every milliliter 0.1 hundred million.
Embodiment 6:
Contain the Radix Astragali in the oral liquid, Rhizoma Polygonati, Radix Ginseng, Radix Codonopsis, Placenta Hominis, Radix Ophiopogonis, Herba Cistanches, Fructus Jujubae, glucose, inorganic salt and yeast, amount of yeast is every milliliter 0.2 ten thousand.
Claims (7)
1, a kind of biological oral liquid contains useful viable bacteria, it is characterized in that also containing tonification Chinese medicine.
2, biological oral liquid according to claim 1 is characterized in that said useful viable bacteria mainly is made up of the strain in the Lactobacillus.
3, biological oral liquid according to claim 1 is characterized in that said useful viable bacteria mainly is made up of the strain in the Bifidobacterium.
4, biological oral liquid according to claim 1 is characterized in that said useful viable bacteria mainly is made up of lactobacillus and bacillus bifidus.
5,, it is characterized in that said tonification Chinese medicine mainly consists of the Radix Astragali, Radix Ginseng, Radix Codonopsis, Rhizoma Polygonati, Mel, Fructus Jujubae, Pericarpium Citri Reticulatae, Fructus Crataegi, Placenta Hominis, Fructus Lycii, Fructus Ligustri Lucidi and Radix Ophiopogonis according to claim 1,2,3 or 4 described biological oral liquids.
6, biological oral liquid according to claim 5 is characterized in that containing in per 10,000 milliliters of oral liquids the Radix Astragali 205～235 grams, Radix Ginseng 8～12 grams, Radix Codonopsis 87～147 grams, Rhizoma Polygonati 175～205 grams, Mel 580～630 grams, Fructus Jujubae 580～630 grams, Pericarpium Citri Reticulatae 100～140 grams, Fructus Crataegi 102～132 grams, Placenta Hominis 230～250 grams, Fructus Lycii 210～250 grams, Fructus Ligustri Lucidi 175～195 grams, Radix Ophiopogonis 175～200 grams, lactobacillus 10
7～10
11Individual, bacillus bifidus 10
7～10
11Individual.
7, biological oral liquid according to claim 6 is characterized in that in per 10,000 milliliters of oral liquids, contains the Radix Astragali 220 grams, Radix Ginseng 10 grams, Radix Codonopsis 117 grams, Rhizoma Polygonati 175 grams, Mel 580 grams, Fructus Jujubae 580 grams, Pericarpium Citri Reticulatae 120 grams, Fructus Crataegi 117 grams, Placenta Hominis 230 grams, Fructus Lycii 230 grams, Fructus Ligustri Lucidi 175 grams, Radix Ophiopogonis 175 grams, Bulgarian Lactobacillus 10
9Individual, the Lactobacillus acidophilus 10
9Individual, bacillus bifidus 10
9Individual.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95102084 CN1112012A (en) | 1995-03-08 | 1995-03-08 | Biological oral liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95102084 CN1112012A (en) | 1995-03-08 | 1995-03-08 | Biological oral liquid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1112012A true CN1112012A (en) | 1995-11-22 |
Family
ID=5074172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 95102084 Pending CN1112012A (en) | 1995-03-08 | 1995-03-08 | Biological oral liquid |
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| Country | Link |
|---|---|
| CN (1) | CN1112012A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1064842C (en) * | 1995-12-07 | 2001-04-25 | 青岛市海慈医疗集团海慈医院 | Jade-supplementing bagged medicinal preparation and its prepn. method |
| CN1099289C (en) * | 1997-08-01 | 2003-01-22 | 北京东方百信生物技术有限公司 | Medicinal prepn. contg. beneficial bacteria named 'Junyikang' and method for preparing same |
| CN102100710B (en) * | 2009-12-22 | 2013-05-01 | 王增刚 | Fermentation processing method for ginseng and research and development of related products thereof |
| CN111514255A (en) * | 2020-06-22 | 2020-08-11 | 江西两碗米饭生物科技有限公司 | Traditional Chinese medicine preparation capable of improving gastrointestinal tract fermentation and preparation method thereof |
| CN112655850A (en) * | 2021-01-08 | 2021-04-16 | 刘冬健 | Rehabilitation beverage |
-
1995
- 1995-03-08 CN CN 95102084 patent/CN1112012A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1064842C (en) * | 1995-12-07 | 2001-04-25 | 青岛市海慈医疗集团海慈医院 | Jade-supplementing bagged medicinal preparation and its prepn. method |
| CN1099289C (en) * | 1997-08-01 | 2003-01-22 | 北京东方百信生物技术有限公司 | Medicinal prepn. contg. beneficial bacteria named 'Junyikang' and method for preparing same |
| CN102100710B (en) * | 2009-12-22 | 2013-05-01 | 王增刚 | Fermentation processing method for ginseng and research and development of related products thereof |
| CN111514255A (en) * | 2020-06-22 | 2020-08-11 | 江西两碗米饭生物科技有限公司 | Traditional Chinese medicine preparation capable of improving gastrointestinal tract fermentation and preparation method thereof |
| CN112655850A (en) * | 2021-01-08 | 2021-04-16 | 刘冬健 | Rehabilitation beverage |
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