CN110960638A

CN110960638A - Composition for reducing uric acid and preparation method thereof

Info

Publication number: CN110960638A
Application number: CN201911392528.7A
Authority: CN
Inventors: 李刚
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-12-30
Filing date: 2019-12-30
Publication date: 2020-04-07

Abstract

The invention discloses a composition for reducing uric acid and a preparation method thereof, wherein the composition comprises the following raw materials in parts by weight: american ginseng: 50-70 parts of medlar: 55-70 parts of chicory: 55-75 parts of kudzu root: 50-65 parts of gardenia: 45-65 parts of mulberry leaf: 50-73 parts of gordon euryale seed: 45-68 parts of coix seed: 56-70 parts of poria cocos: 50-70 parts of dandelion: 52-66 parts of lotus leaves: 54-64 parts of lophatherum gracile: 50-70 parts of maltodextrin: 120-150 parts of sucrose: 100 and 130 parts of magnesium stearate: 15-25 parts. The effective components are extracted by the extraction process of the herbaceous plants, so that the small dosage can be greatly improved, and the aims of effectively controlling uric acid and being convenient to carry and take are achieved. The invention extracts the active ingredients of the pure natural medicinal and edible plants, can effectively relieve gout symptoms and does not cause side effect on human bodies.

Description

Composition for reducing uric acid and preparation method thereof

Technical Field

The invention belongs to the field of preparation of uric acid reducing compositions, and particularly relates to a uric acid reducing composition and a preparation method thereof.

Background

Gout is a hereditary or acquired metabolic disease, and of about 610 gout patients in the united states, about 5 million patients are refractory. The number of hyperuricemia in China reaches 1.2 million, wherein the number of gout patients exceeds 1700 million, and the annual growth rate is rapidly increased by 9.7 percent each year. Gout and hyperuricemia have become the second major metabolic disease in China, second to diabetes, and sex and age, family and heredity, race and region, obesity and drinking are related. It is currently believed that patients with gout and hyperuricemia who have a longer onset and course of disease, about 1/3, may develop renal complications and greatly increase the risk of cardiovascular and cerebrovascular diseases and diabetes. Modern life social attention is frequent, high purine and high fat are taken, the spleen and the stomach are more easily damaged, water-dampness transportation and transformation disorder, dampness blocks spleen yang, spleen dysfunction, dampness retention and accumulation, phlegm-dampness internal heat accumulation and toxic heat exuberance induce gout acute attack patients to increase year by year; the western medicine treatment mainly takes medicine for relieving pain, even removes gout nodules influencing functional activities, and the western medicine treatment takes medicine until pain is relieved or diarrhea occurs, so that gastrointestinal discomfort and liver and kidney damage are easily caused, and psychological burden of patients is increased to a certain extent.

In the aspects of reducing uric acid and controlling gout, western medicines have no radical treatment method, although the commonly used anti-gout medicines such as colchicine, non-steroidal anti-inflammatory drugs, allopurinol and the like can relieve symptoms and reduce uric acid, the effect is single, gout is difficult to treat fundamentally, and the harm to the body after long-term administration is far more than the treatment effect.

The existing Chinese patent medicines have many defects in the prevention and treatment of the uric acid reduction, such as strong drug dependence, frequent administration and incapability of stopping the administration, and the effect is still to be improved. In addition, when multiple medicines are used in a compatible manner, the complex formula has complex composition, the quality control of the traditional Chinese medicinal materials is difficult, and part of the traditional Chinese medicinal materials also contain some medicinal components harmful to the human body, so that the traditional Chinese medicinal materials can be enriched after being taken for a long time and harm the health of the human body.

Disclosure of Invention

Aiming at the defects in the prior art, the invention provides the composition for reducing uric acid and the preparation method thereof, and the effective components are extracted by the extraction process of the herbaceous plants, so that the small dose can be greatly improved, and the aims of effectively controlling uric acid and being convenient to carry and take are fulfilled. The invention extracts the active ingredients of the pure natural medicinal and edible plants, can effectively relieve gout symptoms and does not cause side effect on human bodies.

Therefore, the invention discloses a composition for reducing uric acid, which comprises the following raw materials in parts by weight: american ginseng: 50-70 parts of medlar: 55-70 parts of chicory: 55-75 parts of kudzu root: 50-65 parts of gardenia: 45-65 parts of mulberry leaf: 50-73 parts of gordon euryale seed: 45-68 parts of coix seed: 56-70 parts of poria cocos: 50-70 parts of dandelion: 52-66 parts of lotus leaves: 54-64 parts of lophatherum gracile: 50-70 parts of maltodextrin: 120-150 parts of sucrose: 100 and 130 parts of magnesium stearate: 15-25 parts.

Further, the feed comprises the following raw materials in parts by weight: american ginseng: 50 parts of medlar: 55 parts of chicory: 55 parts of kudzu root: 50 parts of gardenia: 45 parts of mulberry leaves: 50 parts of gordon euryale seed: 45 parts of coix seeds: 56 parts of poria cocos: 50 parts of dandelion: 52 parts of lotus leaves: 54 parts of lophatherum gracile: 50 parts of maltodextrin: 120 parts of sucrose: 100 parts, magnesium stearate: 15 parts.

Further, the feed comprises the following raw materials in parts by weight: american ginseng: 60 parts of medlar: 60 parts of chicory: 60 parts of kudzu root: 60 parts of gardenia: 60 parts of mulberry leaves: 60 parts of gordon euryale seed: 60 parts of coix seeds: 60 parts of poria cocos: 60 parts of dandelion: 60 parts of lotus leaves: 60 parts of lophatherum gracile: 60 parts of maltodextrin: 140 parts of sucrose: 120 parts, magnesium stearate: and 20 parts.

Further, the feed comprises the following raw materials in parts by weight: american ginseng: 70 parts of medlar: 70 parts of chicory: 75 parts of kudzu root: 65 parts of fructus gardeniae: 65 parts of mulberry leaves: 73 parts of gorgon fruit: 68 parts of coix seeds: 70 parts of poria cocos: 70 parts of dandelion: 66 parts and lotus leaves: 64 parts of lophatherum gracile: 70 parts of maltodextrin, namely: 150 parts of sucrose: 130 parts and magnesium stearate: and 25 parts.

A preparation method of the uric acid reducing composition comprises the following steps:

weighing, namely weighing the raw material components according to the proportion of any one of the components.

Crushing, namely crushing the raw materials into fine powder by a crusher, and screening by a 800-plus 1000-mesh screen.

Treating, extracting the pulverized components at a ratio of 30:1 with high concentration, concentrating, purifying, and drying at 55-65 deg.C to obtain particulate with water content of less than 0.5%.

Tabletting, namely tabletting the components in an environment with the relative humidity of the environment below 60% by adopting a tabletting machine to obtain a finished product.

And (4) packaging, namely packaging and sealing the packaging bag or the packaging box after sterilization.

The invention has the beneficial effects that: the composition has the advantages that the selected medicinal materials are compatible, and the poria cocos is capable of clearing damp and promoting diuresis, tonifying spleen and stomach and tonifying without stagnation; the kudzu vine root can clear wind-cold, eliminate exterior pathogen, relieve muscle heat and stop polydipsia; cape jasmine has the effects of clearing away heat and toxic materials, dredging collaterals and relieving pain; lophatherum gracile has the effects of clearing heat and purging fire, strengthening the diuresis-inducing property of tuckahoe, and folium mori can dispel wind-heat and is combined with kudzu root to strengthen the arthralgia-removing and pain-relieving effects of kudzu root. The medicines are combined to play the effects of promoting diuresis and excreting dampness, clearing heat and detoxicating, and removing arthralgia and relieving pain. Convenient use, good absorption effect, no adverse side effect, and capability of obviously reducing the uric acid value, and is suitable for preventing and treating the gouty arthritis.

Detailed Description

It is to be noted that, unless otherwise specified, technical or scientific terms used herein shall have the ordinary meaning as understood by those skilled in the art to which the invention pertains.

American ginseng: american ginseng is cold in nature, sweet and slightly bitter in taste, enters heart, lung and spleen channels, has the functions of tonifying qi and yin, purging fire and relieving restlessness, nourishing stomach and promoting fluid production, is suitable for treating fire symptoms caused by qi and yin deficiency, and is mainly used for lung heat dry cough, qi deficiency, hui yan, limbs fatigue, dysphoria, irritability, yin and body fluid loss caused by heat disease and the like.

Medlar: the fructus Lycii has effects of protecting liver, reducing blood sugar, softening blood vessel, and reducing cholesterol and triglyceride level in blood, and has certain therapeutic effect on fatty liver and diabetes.

Chicory: has the effects of clearing liver-fire, promoting bile flow, invigorating stomach, resolving food stagnation, inducing diuresis and relieving swelling, and can be used for treating damp-heat jaundice, stomach ache, anorexia, edema and oliguria. Chicory root contains phenolic compounds, saccharides, flavonoids, triterpenes, sesquiterpene lactones, coumarins and other components. Wherein, the most functional nutrient component in the chicory root is inulin, and the content of the inulin is up to 15 to 20 percent. Currently, inulin and fructooligosaccharides are the most commonly used food additive ingredients as prebiotics. Meanwhile, chicory also contains bitter substances which are not contained in common vegetables, such as aesculin (Esculetin), aesculin (Esculin), Lactucin (cichororiin), Lactucin (Lactucin) and Lactucin (lactucimicin). The bitter substances have antibacterial, digestion improving, liver heat removing, gallbladder function promoting, and hangover relieving effects. The chicory extract is found to have good uric acid reducing effect for the first time by Zhang Bing, Liu Xiao Qing and the like. Research finds that the chicory extract can reduce the blood uric acid level of a uricosuric mouse or a C57 mouse fed with a uricosuric inhibitor bait, and can better resist the high uric acid state of the model animal. And the chicory extract has a good regulating effect on the quail hyperuricemia induced by the high-purine diet, can obviously reduce the blood uric acid level of model animals, and has long action duration. Researches such as Linzhijian and the like find that the chicory extract can reduce the serum uric acid level of a model animal, remarkably reduce the abdominal fat amount and abdominal fat rate of the model animal, inhibit the increase of abdominal fat cells and prompt that the chicory extract can effectively intervene hyperuricemia and abdominal obesity. The chicory extract can reduce the activity of the hyperuricemia model quail serum x0D, inhibit the generation of uric acid and reduce the blood uric acid level. Meanwhile, researches find that the chicory can improve the uric acid clearance rate and reduce the blood uric acid level of mice. Suggesting that chicory extract may interfere in hyperuricemia from multiple pathways of uric acid production and excretion.

Kudzu root: improving microcirculation, dissolving and preventing urate crystal deposition. Nourishing cardiac muscle, relieving exterior syndrome, lowering blood sugar and blood fat. Lifting yang qi, quenching thirst and checking diarrhea. Cool in nature, mild in smell and sweet in taste, has the effects of clearing heat, reducing pathogenic fire, expelling toxin and the like, and the isoflavone compound of the wild puerarin also has certain curative effects on hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular diseases.

Gardenia: bitter and cold in nature. It enters heart, lung and triple energizer meridians. The main treatment is as follows: purging fire, relieving restlessness, clearing heat, inducing diuresis, cooling blood and removing toxicity. Can be used for treating vexation, jaundice due to damp-heat pathogen, stranguria, hematemesis, epistaxis, and pyocutaneous disease due to pathogenic fire.

Mulberry leaf: dispelling wind heat: for wind-heat type common cold and red eyes with swelling pain, it is often combined with Ju Hua. (2) Clearing liver and improving vision: can be used for treating eye diseases due to wind-fire (such as acute conjunctivitis). It is combined with black sesame and mulberry pill to treat dizziness and blurred vision caused by liver yin deficiency and liver yang hyperactivity.

Gorgon fruit: tonify kidney, secure essence, tonify spleen, check diarrhea, remove dampness and stop leukorrhagia. Can be used for treating spermatorrhea, enuresis, frequent micturition, spleen deficiency, and chronic diarrhea.

Coix seed: has cool nature, sweet and bland taste, enters spleen, lung and kidney meridians, and has the effects of promoting diuresis, invigorating spleen, removing arthralgia, clearing heat and expelling pus.

Tuckahoe, poria cocos: sweet, bland and mild in nature; it enters lung, spleen and kidney meridians. The main treatment is as follows: induce diuresis to alleviate edema. Can be used for treating edema and dysuria. Has effects of eliminating dampness, promoting diuresis, invigorating spleen, regulating stomach function, calming heart, tranquilizing mind, and treating joint pain, urinary tract infection, leucorrhea, suppurative sore, syphilis, and erythroderma.

Dandelion: belongs to a plurality of plants for clearing away heat and toxic material, inducing diuresis and resolving masses. Treating acute mastitis, lymphadenitis, scrofula, furunculosis, acute conjunctivitis, common cold with fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, and urinary tract infection; the dandelion extract is used for treating liver and gallbladder obstruction, improving liver function, promoting bile secretion and as diuretic.

Lotus leaf: lotus leaf is bitter and astringent in flavor, neutral in nature, and enters liver, spleen, stomach and heart meridians. Has effects of clearing summer-heat, promoting diuresis, raising hair, clearing yang, cooling blood, and stopping bleeding. The alkaloid in folium Nelumbinis has effects of reducing blood lipid, scavenging free radicals, inhibiting hypercholesterolemia and arteriosclerosis, and promoting dietetic therapy, and also has antimitotic effect and antibacterial effect.

Herba lophatheri: has the effects of cooling, relieving fever, promoting urination and inducing spawning; the main treatment is as follows: chest fever, cough, hemoptysis, toxic heat wind, thirst, erysipelas, phlegm, mania, vexation, aphonia, headache, palpitation, epidemic, vexation, and parasite killing.

Example one

The embodiment discloses a uric acid reducing composition, which comprises the following raw materials in parts by weight: american ginseng: 50 parts of medlar: 55 parts of chicory: 55 parts of kudzu root: 50 parts of gardenia: 45 parts of mulberry leaves: 50 parts of gordon euryale seed: 45 parts of coix seeds: 56 parts of poria cocos: 50 parts of dandelion: 52 parts of lotus leaves: 54 parts of lophatherum gracile: 50 parts of maltodextrin: 120 parts of sucrose: 100 parts, magnesium stearate: 15 parts.

Example two

The embodiment discloses a uric acid reducing composition, which comprises the following raw materials in parts by weight: american ginseng: 70 parts of medlar: 70 parts of chicory: 75 parts of kudzu root: 65 parts of fructus gardeniae: 65 parts of mulberry leaves: 73 parts of gorgon fruit: 68 parts of coix seeds: 70 parts of poria cocos: 70 parts of dandelion: 66 parts and lotus leaves: 64 parts of lophatherum gracile: 70 parts of maltodextrin, namely: 150 parts of sucrose: 130 parts and magnesium stearate: and 25 parts.

EXAMPLE III

The embodiment discloses a uric acid reducing composition, which comprises the following raw materials in parts by weight: american ginseng: 60 parts of medlar: 60 parts of chicory: 60 parts of kudzu root: 60 parts of gardenia: 60 parts of mulberry leaves: 60 parts of gordon euryale seed: 60 parts of coix seeds: 60 parts of poria cocos: 60 parts of dandelion: 60 parts of lotus leaves: 60 parts of lophatherum gracile: 60 parts of maltodextrin: 140 parts of sucrose: 120 parts, magnesium stearate: and 20 parts.

Taking the third example as the example with the best curative effect in the three examples as an illustration, taking the uric acid reducing composition of the third example, taking 0.7 g/capsule of the composition: 4 capsules per day, taken continuously for 6 days, and then assayed for uric acid. High-purine foods such as tobacco wine, animal viscera, seafood, beans, high protein and the like are forbidden during administration.

And the composition of example three was prepared in the following manner: weighing according to the weight ratio of 60mg and medlar: 60mg, chicory: 60mg, kudzu root: 60mg, gardenia: 60mg, mulberry leaf: 60mg, gorgon fruit: 60mg, coix seed: 60mg, Poria cocos: 60mg, dandelion: 60mg, lotus leaf: 60mg, lophatherum gracile: 60mg, maltodextrin: 140 mg, sucrose: 120 mg, magnesium stearate: 20 mg of the raw material is weighed.

The composition has the following curative effect evaluation standards: after the drug is taken by a patient, the uric acid can be obviously reduced and controlled within a normal value (149-416 umol/L for men and 89-357 umo1/L for women).

The therapeutic results of the uric acid lowering compositions of this example are illustrated below: the product is used for treating 30 patients with high uric acid, the result shows that 28 patients have obvious effect, the total effective rate is 93.0 percent, the average value of uric acid of the 30 patients before taking the product is 602umol/L, and the average value of uric acid after taking the product for 6 days is 387 umol/L. No allergic or other adverse reactions were observed during the administration. Therefore, the uric acid-reducing medicinal and edible drink has the advantages of obvious effect, obvious uric acid reduction, good safety and convenience in taking.

Case 1

Male 1, uric acid value before taking the composition is 908 umol/L, uric acid retest value after taking the composition for 6 days is 304 umol/L, and uric acid retest value after taking the composition for two weeks is 256 umol/L.

Case 2

Male 2 had a uric acid value of 612 umol/L before taking the composition, and a uric acid retest value of 368umol/L after 6 days of taking the composition.

Case 3

Male 3, uric acid value before taking the composition was 502 umol/L, and uric acid retest value after taking the composition for 6 days was 265 umol/L.

Case 4

For woman 1, the uric acid value before taking the composition is 754umol/L, the uric acid retest value after taking the composition for 6 days is 562umol/L, and the uric acid retest value after taking the composition for two weeks is 340 umol/L.

Case 5

Female 2, uric acid value before taking the composition was 752 umol/L, uric acid retest value after 6 days was 520 umol/L, and uric acid retest value after taking the composition for two weeks was 314 umol/L.

Case 6

Female 3, uric acid value before taking the composition is 497umol/L, and uric acid value after taking 6 days is 291 umol/L.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention, and they should be construed as being included in the following claims and description.

Claims

1. The composition for reducing uric acid is characterized by comprising the following raw materials in parts by weight: american ginseng: 50-70 parts of medlar: 55-70 parts of chicory: 55-75 parts of kudzu root: 50-65 parts of gardenia: 45-65 parts of mulberry leaf: 50-73 parts of gordon euryale seed: 45-68 parts of coix seed: 56-70 parts of poria cocos: 50-70 parts of dandelion: 52-66 parts of lotus leaves: 54-64 parts of lophatherum gracile: 50-70 parts of maltodextrin: 120-150 parts of sucrose: 100 and 130 parts of magnesium stearate: 15-25 parts.

2. The uric acid reducing composition according to claim 1, characterized by comprising the following raw materials in parts by weight: american ginseng: 50 parts of medlar: 55 parts of chicory: 55 parts of kudzu root: 50 parts of gardenia: 45 parts of mulberry leaves: 50 parts of gordon euryale seed: 45 parts of coix seeds: 56 parts of poria cocos: 50 parts of dandelion: 52 parts of lotus leaves: 54 parts of lophatherum gracile: 50 parts of maltodextrin: 120 parts of sucrose: 100 parts, magnesium stearate: 15 parts.

3. The uric acid reducing composition according to claim 1, characterized by comprising the following raw materials in parts by weight: american ginseng: 60 parts of medlar: 60 parts of chicory: 60 parts of kudzu root: 60 parts of gardenia: 60 parts of mulberry leaves: 60 parts of gordon euryale seed: 60 parts of coix seeds: 60 parts of poria cocos: 60 parts of dandelion: 60 parts of lotus leaves: 60 parts of lophatherum gracile: 60 parts of maltodextrin: 140 parts of sucrose: 120 parts, magnesium stearate: and 20 parts.

4. The uric acid reducing composition according to claim 1, characterized by comprising the following raw materials in parts by weight: american ginseng: 70 parts of medlar: 70 parts of chicory: 75 parts of kudzu root: 65 parts of fructus gardeniae: 65 parts of mulberry leaves: 73 parts of gorgon fruit: 68 parts of coix seeds: 70 parts of poria cocos: 70 parts of dandelion: 66 parts and lotus leaves: 64 parts of lophatherum gracile: 70 parts of maltodextrin, namely: 150 parts of sucrose: 130 parts and magnesium stearate: and 25 parts.

5. The preparation method of the uric acid reducing composition is characterized by comprising the following steps of:

weighing, namely weighing the raw material components according to the proportion of any one of the components in claims 1 to 4;

crushing, namely crushing the raw materials into fine powder by a crusher, and screening by a 800-plus-1000-mesh screen;

processing, namely extracting the crushed components at a high concentration according to a ratio of 30:1, and then respectively concentrating, purifying and drying, wherein the drying temperature is controlled to be 55-65 ℃, and the moisture content of the dried particles is lower than 0.5%;

tabletting, namely tabletting the components in an environment with the relative humidity of the environment below 60% by using a tabletting machine to obtain a finished product;