CN110292632A - A kind of tumor thermotherapy particle - Google Patents
A kind of tumor thermotherapy particle Download PDFInfo
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- CN110292632A CN110292632A CN201910595260.0A CN201910595260A CN110292632A CN 110292632 A CN110292632 A CN 110292632A CN 201910595260 A CN201910595260 A CN 201910595260A CN 110292632 A CN110292632 A CN 110292632A
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- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 103
- 239000002245 particle Substances 0.000 title claims abstract description 93
- 238000000015 thermotherapy Methods 0.000 title claims abstract description 54
- 239000000463 material Substances 0.000 claims abstract description 55
- 238000010438 heat treatment Methods 0.000 claims abstract description 34
- 239000012779 reinforcing material Substances 0.000 claims abstract description 12
- 230000009471 action Effects 0.000 claims abstract description 6
- 206010020843 Hyperthermia Diseases 0.000 claims description 43
- 230000036031 hyperthermia Effects 0.000 claims description 43
- 230000009467 reduction Effects 0.000 claims description 22
- 230000005484 gravity Effects 0.000 claims description 8
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 6
- 229910000990 Ni alloy Inorganic materials 0.000 claims description 6
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 6
- 230000002708 enhancing effect Effects 0.000 claims description 6
- 229910000640 Fe alloy Inorganic materials 0.000 claims description 4
- 229910010293 ceramic material Inorganic materials 0.000 claims description 4
- 239000007769 metal material Substances 0.000 claims description 4
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 3
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 3
- HZEWFHLRYVTOIW-UHFFFAOYSA-N [Ti].[Ni] Chemical compound [Ti].[Ni] HZEWFHLRYVTOIW-UHFFFAOYSA-N 0.000 claims description 3
- 230000020169 heat generation Effects 0.000 claims description 3
- 229910052742 iron Inorganic materials 0.000 claims description 3
- 239000010936 titanium Substances 0.000 claims description 3
- 229910052719 titanium Inorganic materials 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 230000005855 radiation Effects 0.000 abstract 1
- 230000001965 increasing effect Effects 0.000 description 6
- 230000006698 induction Effects 0.000 description 6
- 230000003247 decreasing effect Effects 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 230000003313 weakening effect Effects 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 239000011553 magnetic fluid Substances 0.000 description 2
- 229920000049 Carbon (fiber) Polymers 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 239000004917 carbon fiber Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000006249 magnetic particle Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052755 nonmetal Inorganic materials 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
Abstract
The invention discloses a kind of tumor thermotherapy particles, including contact portion, heating part and hot vector portion；Contact portion is wrapped in outside heating part and hot vector portion, and heating part and hot vector portion are kept apart with human body；Heating part is made of magneto-caloric material, with heat production under the action of alternating magnetic field；Hot vector portion is between heating part and contact portion, and hot vector portion weakens material by hot reinforcing material and/or heat and is made, to improve and/or reduce the heat that heating part is radiated towards contact portion direction.The hot vector portion of the disclosure can enhance or weaken the heating part of tumor thermotherapy particle towards on the different directions of contact portion to the heat of external radiation; it realizes multiplicity and thermal field form abundant and temperature rise changes; while tumor tissues are killed in heating, the normal cell tissue around tumor tissues is protected.
Description
Technical Field
The invention relates to the field of thermal therapy, in particular to tumor thermal therapy particles.
Background
Tumor hyperthermia refers to a therapeutic method for treating tumors by means of heat. The tumor therapy by the heat therapy is also a technology which is hopefully expected and has wide medical application prospect, and becomes one of effective means for the combined therapy of the tumors except for the operation, the chemotherapy and the radiotherapy. The tumor thermotherapy heats the whole or local part of a human body by using physical energy, so that the temperature of tumor tissues is raised to an effective treatment temperature and is maintained for a certain time, and the treatment aim of apoptosis of tumor cells and no damage to the normal tissues is fulfilled by using the difference of the temperature tolerance capacities of the normal tissues and the tumor cells.
Common tumor thermotherapy techniques include ultrasound thermotherapy, microwave thermotherapy, radio frequency thermotherapy, magnetic induction thermotherapy, and the like. The magnetic induction thermotherapy is to introduce or target the magnetic medium into tumor, and the magnetic medium is heated under the action of external alternating magnetic field to form shape or target and kill tumor cells. Due to the heating specificity of the magnetic induction thermotherapy and the characteristics of technologies such as three-dimensional conformation and targeted implantation, the magnetic induction thermotherapy becomes a hot point for research.
The magnetic medium used in magnetic induction thermotherapy mainly comprises magnetic fluid and particles. The magnetic fluid presents a fluid state after being injected into a human body, and is difficult to position and shape. The particles are difficult to adjust in time after being implanted into the tumor area. If the particles implanted into the tumor area are distributed unreasonably, the problem of damaging normal cell tissues around the tumor is easily caused.
Therefore, how to provide tumor hyperthermia particles capable of effectively enhancing vector property of heat generation becomes a technical problem to be solved urgently in the field.
Disclosure of Invention
An object of the present invention is to provide a new technical solution of tumor hyperthermia particles that can effectively increase the vectorial properties of heat production.
According to a first aspect of the present invention, a tumor hyperthermia particle is provided.
The tumor thermotherapy particle comprises a contact part, a heating part and a heat vector part; wherein,
the contact part is wrapped outside the heating part and the heat vector part so as to isolate the heating part and the heat vector part from a human body;
the heating part is made of a magnetocaloric material to generate heat under the action of an alternating magnetic field;
the heat vector portion is located between the heat generating portion and the contact portion, and the heat vector portion is made of a heat reinforcing material and/or a heat reducing material to increase and/or decrease heat radiated from the heat generating portion toward the contact portion.
Optionally, the contact portion is made of one of pure titanium, a titanium alloy, a titanium-nickel alloy and a non-metal material;
the heating part is made of one of pure iron, pure nickel and iron alloy.
Optionally, the center of gravity of the heat generating portion coincides with the center of gravity of the tumor hyperthermia particles.
Optionally, the heat generating portion on the width-directional cross section of the tumor hyperthermia particle has a circular shape, and the contact portion on the width-directional cross section of the tumor hyperthermia particle has a ring shape.
Optionally, the thermal vector portion includes a thermal enhancement layer made of a thermal enhancement material, and only one layer of the thermal enhancement layer is provided along the heat generating portion toward the contact portion; or,
the heat vector portion includes a heat reduction layer made of a heat reduction material, and only one layer of the heat reduction layer is provided along the heat generation portion in a direction toward the contact portion; or,
the heat vector portion includes a heat-reinforcing layer made of a heat-reinforcing material and a heat-attenuating layer made of a heat-attenuating material, and only one of the heat-reinforcing layer or the heat-attenuating layer is provided along the heat-generating portion in a direction toward the contact portion.
Optionally, the material of the heat-enhancing layer is the same as the material of the heat-generating portion.
Optionally, the material of the thermal reduction layer is a ceramic material.
Optionally, the thickness of the heat enhancing layer or the heat reduction layer in different directions along the heat generating portion to the contact portion is constant.
Optionally, the heat vector portion is wrapped outside the heat generating portion to isolate the contact portion from the heat generating portion.
Optionally, the tumor thermotherapy particle comprises a cylindrical section and hemispherical sections located at both ends of the cylindrical section, the cylindrical section has a cylindrical shape, and the hemispherical sections have a hemispherical shape.
The heat vector part can enhance or weaken heat radiated outwards from the heating part of the tumor thermotherapy particle towards different directions of the contact part, realize various and abundant heat field forms and temperature rise changes, and protect normal cell tissues around the tumor tissues while heating and killing the tumor tissues.
Other features of the present invention and advantages thereof will become apparent from the following detailed description of exemplary embodiments thereof, which proceeds with reference to the accompanying drawings.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description, serve to explain the principles of the invention.
Fig. 1 is a schematic structural diagram of a tumor hyperthermia particle according to a first embodiment of the present disclosure.
Fig. 2 is a schematic structural diagram of a second embodiment of the tumor hyperthermia particle of the present disclosure.
The figures are labeled as follows:
a contact part-1, a heating part-2, a thermal vector part-3, a thermal enhancement layer-31 and a thermal reduction layer-32.
Detailed Description
Various exemplary embodiments of the present invention will now be described in detail with reference to the accompanying drawings. It should be noted that: the relative arrangement of the components and steps, the numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present invention unless specifically stated otherwise.
The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the invention, its application, or uses.
Techniques, methods, and apparatus known to those of ordinary skill in the relevant art may not be discussed in detail but are intended to be part of the specification where appropriate.
In all examples shown and discussed herein, any particular value should be construed as merely illustrative, and not limiting. Thus, other examples of the exemplary embodiments may have different values.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, further discussion thereof is not required in subsequent figures.
In order to solve the problem that particles used in the existing magnetic induction thermotherapy harm normal cell tissues around a tumor, the present disclosure provides a tumor thermotherapy particle.
As shown in fig. 1 and 2, the tumor thermotherapy particle of the present disclosure includes a contact part 1, a heat generating part 2, and a heat vector part 3.
The contact part 1 is a part where the tumor thermotherapy particle is directly contacted with the human body. Typically, the material of the contact portion 1 is a human body compatible material. Such as metallic materials or carbon fibers, etc.
The heating part 2 is a main part of the tumor thermotherapy particle that generates heat under the action of an external magnetic field. The tumor thermotherapy particles can be heated up by the heating part 2. Generally, the heat generating portion 2 is a material having a magnetocaloric effect.
The thermal vector portion 3 refers to a portion of the tumor hyperthermia particles that can increase or decrease the amount of heat radiated from the particles. In general, the material of the thermal vector portion 3 is a material that can enhance the magnetic field to increase the amount of heat radiated from the particles; and/or the material of the thermal vector part 3 is a material which can weaken a magnetic field or play a role of heat insulation so as to reduce the heat radiated outside by the particles.
The shape of the tumor hyperthermia particles of the present disclosure can be specifically set according to actual needs. In a specific implementation, the tumor hyperthermia particles can have a smooth outer contour to reduce the risk of the tumor hyperthermia particles puncturing the tumor membrane after being implanted into the tumor. The heating part 2 of the tumor thermotherapy particle may have a regular shape, for example, a spherical shape, a cylindrical shape, or a rectangular parallelepiped shape, to improve the controllability of the heat radiated from the tumor thermotherapy particle. The thermal vector portion 3 of the tumor thermotherapy particle may have a regular shape, for example, a semi-arc shape or a ring shape, to improve the controllability of the heat radiated from the tumor thermotherapy particle.
The contact portion 1 is wrapped around the heat generating portion 2 and the heat vector portion 3 to isolate the heat generating portion 2 and the heat vector portion 3 from the human body. The contact part 1 can completely wrap the heating part 2 and the heat vector part 3, thereby effectively avoiding the direct contact between the heating part 2 or the heat vector part 3 and the human body.
The heat generating portion 2 is made of a magnetocaloric material to generate heat under the action of an alternating magnetic field.
The heat vector portion 3 is located between the heat generating portion 2 and the contact portion 1, and the heat vector portion 3 is made of a heat reinforcing material and/or a heat reducing material to increase and/or decrease the amount of heat radiated from the heat generating portion 2 toward the contact portion 1. The thermal enhancement material is a material that can enhance the magnetic field to increase the amount of heat radiated from the particles, such as an iron alloy. The heat-weakening material is a material that weakens a magnetic field or plays a role of heat insulation to reduce heat radiated from particles, such as a ceramic material.
The heat vector part 3 may completely wrap the heat generating part 2 such that the heat generating part 2 and the contact part 1 are completely isolated, thereby increasing or decreasing the amount of heat radiated from the heat generating part 2 toward any direction of the contact part 1. The heat vector portion 3 may also be located only between part of the outer surface of the heat generating portion 2 and part of the inner surface of the contact portion 1, thereby increasing or decreasing the amount of heat radiated by the heat generating portion 2 in certain directions toward the contact portion 1.
One skilled in the art can select the appropriate material and structure of the thermal vector portion 3 according to actual requirements.
For example, the thermal vector part 3 is composed of only a thermal reinforcing material between a portion of the outer surface of the heat generating part 2 and a portion of the inner surface of the contact part 1, thereby increasing the amount of heat radiated outward from the region where the tumor thermotherapy particles have the thermal reinforcing material.
For another example, the thermal vector portion 3 is composed of only a thermal reduction material between a portion of the outer surface of the heat generating portion 2 and a portion of the inner surface of the contact portion 1, thereby reducing the amount of heat radiated outward from the region where the tumor thermotherapy particles have the thermal reduction material.
For another example, the thermal vector unit 3 is formed by a thermal reinforcing material between a portion of the outer surface of the heat generating unit 2 and a portion of the inner surface of the contact unit 1, and a thermal weakening material between a portion of the outer surface of the heat generating unit 2 and a portion of the inner surface of the contact unit 1, thereby increasing the amount of heat radiated outward from the region of the tumor thermotherapy particles having the thermal reinforcing material and decreasing the amount of heat radiated outward from the region of the tumor thermotherapy particles having the thermal weakening material.
The thermal vector portion 3 may have one or more thermal reinforcements. By the cooperation of various heat-enhanced materials, the tumor thermotherapy particle can realize more various and abundant thermal field forms and temperature rise changes. The heat vector portion 3 may have one or more heat-weakening materials. By matching various heat weakening materials, the tumor thermotherapy particle can realize more various and abundant thermal field forms and temperature rise changes.
For the thermal vector portion 3 composed of the thermal enhancement material and the thermal reduction material together, the region of the tumor thermotherapy particle having the thermal enhancement material and the region having the thermal reduction material are not overlapped or overlapped in general, so as to improve the controllability of the heat radiated from the tumor thermotherapy particle.
In one embodiment of the tumor thermotherapy particle of the present disclosure, the material of the contact portion 1 is one of pure titanium, titanium alloy, titanium-nickel alloy and non-metallic material. The skilled person can flexibly select a suitable material for the contact portion 1 according to actual requirements, which is not further limited by the present disclosure.
The material of the heating part 2 is one of pure iron, pure nickel and iron alloy. The skilled person can flexibly select the suitable material of the heat generating portion 2 according to the actual requirement, which is not further limited by the present disclosure.
In one embodiment of the tumor hyperthermia particles of the present disclosure, in order to improve the stability of the position of the tumor hyperthermia particles implanted into the human body, the center of gravity of the heat generating portion 2 coincides with the center of gravity of the tumor hyperthermia particles.
Further, in order to improve controllability of heat radiated outward by the tumor thermotherapy particle, the heat generating portion 2 on the cross section of the tumor thermotherapy particle in the width direction has a circular shape, and the contact portion 1 on the cross section of the tumor thermotherapy particle in the width direction has a ring shape.
In one embodiment of the tumor hyperthermia particles of the present disclosure, the thermal vector portion 3 includes a thermal enhancement layer 31 made of a thermal enhancement material, and only one thermal enhancement layer 31 is provided along the heat generating portion 2 in a direction toward the contact portion 1. The heat vector portion 3 comprises only one heat-enhancing layer 31, which is advantageous for reducing the cost of the tumor hyperthermia particles and improving the controllability of the heat radiated from the tumor hyperthermia particles.
In practice, the thickness of the heat-enhancing layer 31 along the heat-generating portion 2 in different directions toward the contact portion 1 can be kept constant, so that the heat radiated from the tumor thermotherapy particles in the region with the heat-enhancing layer 31 can be more stable and reliable.
In one embodiment of the tumor thermotherapy particle of the present disclosure, the heat vector part 3 includes a heat reduction layer 32 made of a heat reduction material, and only one layer of the heat reduction layer 32 is provided along the direction of the heat generating part 2 toward the contact part 1. The thermal vector portion 3 comprises only one thermal reduction layer 32, which is advantageous for reducing the cost of the tumor hyperthermia particles and improving the controllability of the heat radiated from the tumor hyperthermia particles.
In practice, the thickness of the thermal reduction layer 32 along the heating portion 2 in different directions toward the contact portion 1 can be kept constant, so that the tumor thermotherapy particles can radiate heat outward from the region with the thermal reduction layer 32 more stably and reliably.
In one embodiment of the tumor thermotherapy particle of the present disclosure, the heat vector part 3 includes a heat-reinforcing layer 31 made of a heat-reinforcing material and a heat-reduction layer 32 made of a heat-reduction material, and only one heat-reinforcing layer 31 or one heat-reduction layer 32 is provided along the heat-generating part 2 in a direction toward the contact part 1. That is, there is no overlapping or overlapping area between the heat-reinforcing layer 31 and the heat-reducing layer 32, and only one heat-reinforcing layer 31 or only one heat-reducing layer 32 is present in a certain direction along the heat-generating portion 2 toward the contact portion 1. The inclusion of only one heat enhancing layer 31 or one heat reducing layer 32 along the heat generating portion 2 in different directions towards the contact portion 1 facilitates the reduction of the cost of the tumor hyperthermia particles and the improvement of the controllability of the heat radiated outward by the tumor hyperthermia particles.
In practice, the thickness of the heat-enhancing layer 31 or the heat-reducing layer 32 along the heat-generating portion 2 in different directions toward the contact portion 1 can be kept constant, so that the heat radiated from the tumor thermotherapy particles in the region having the heat-enhancing layer 31 or the heat-reducing layer 32 can be more stable and reliable.
Further, in order to control the cost of the tumor thermotherapy particles, the material of the heat-enhancing layer 31 is the same as that of the heat-generating portion 2. Of course, in order to improve the controllability of the heat radiated outward by the tumor thermotherapy particles, the material of the heat-enhancing layer 31 may be selected to be different from that of the heat-generating portion 2.
Further, in order to control the cost of the tumor hyperthermia particles, the material of the thermal reduction layer 32 is a ceramic material.
In one embodiment of the tumor thermotherapy particle of the present disclosure, the heat vector portion 3 is coated outside the heating portion 2 to isolate the contact portion 1 from the heating portion 2. That is, the contact portion 1 and the heat generating portion 2 are completely isolated, thereby increasing or decreasing the amount of heat radiated from the heat generating portion 2 toward any direction of the contact portion 1.
In one embodiment of the tumor hyperthermia particle of the present disclosure, the tumor hyperthermia particle comprises a cylindrical section (not shown in the drawings) and hemispherical sections (not shown in the drawings) located at both ends of the cylindrical section. The cylindrical section has a cylindrical shape and the hemispherical section has a hemispherical shape. The hemisphere section is connected with the end faces of the two ends of the cylindrical section. The tumor thermotherapy particle with the structure has simple structure and is easy to implant.
In the following, in order to more clearly illustrate the tumor hyperthermia particles of the present disclosure, the embodiments shown in fig. 1 and 2 are illustrated, respectively:
as shown in fig. 1, the tumor thermotherapy particle of this embodiment includes a contact part 1, a heat generating part 2, and a heat vector part 3. The edges of the heat generating part 2 and the heat vector part 3 are connected, and the heat generating part 2 and the heat vector part 3 jointly form a circle. The heat vector portion 3 may be composed of a heat reinforcing material or a heat weakening material. The contact portion 1 has an annular shape. The shapes of the components of the tumor thermotherapy particle are mirror symmetry with the contact line of the heating part 2 and the thermal vector part 3 as an axis.
The heat radiated from the tumor hyperthermia particles shown in fig. 1 outside the region having the heat vector portion 3 can be increased or decreased.
As shown in fig. 2, the tumor thermotherapy particle of this embodiment includes a contact portion 1, a heat generating portion 2, and a heat vector portion 3 composed of a heat enhancing layer 31 and a heat reducing layer 32. The heat generating part 2 is located at the center of the tumor hyperthermia particles, which has a circular shape. The heat-reinforcing layer 31 and the heat-reducing layer 32 each have a semicircular ring shape, and both cover half of the outer surface of the heat-generating portion 2, respectively, and the edges of the heat-reinforcing layer 31 and the heat-reducing layer 32 are joined. The contact portion 1 has an annular shape. The center of gravity of the heating part 2 coincides with the center of gravity of the tumor hyperthermia particles. The shapes of the components of the tumor thermotherapy particle are mirror symmetry with the diameter of the heating part 2 as the axis.
The heat radiated from the tumor hyperthermia particles shown in fig. 2 can be enhanced in the region having the heat-enhancing layer 31 and reduced in the region having the heat-attenuating layer 32.
Although some specific embodiments of the present invention have been described in detail by way of examples, it should be understood by those skilled in the art that the above examples are for illustrative purposes only and are not intended to limit the scope of the present invention. It will be appreciated by those skilled in the art that modifications may be made to the above embodiments without departing from the scope and spirit of the invention. The scope of the invention is defined by the appended claims.
Claims (10)
1. A tumor thermotherapy particle comprises a contact part, a heating part and a heat vector part; wherein,
the contact part is wrapped outside the heating part and the heat vector part so as to isolate the heating part and the heat vector part from a human body;
the heating part is made of a magnetocaloric material to generate heat under the action of an alternating magnetic field;
the heat vector portion is located between the heat generating portion and the contact portion, and the heat vector portion is made of a heat reinforcing material and/or a heat reducing material to increase and/or decrease heat radiated from the heat generating portion toward the contact portion.
2. Particles for hyperthermia of tumor according to claim 1, wherein the material of the contact portion is one of pure titanium, titanium alloy, titanium nickel alloy and non-metallic material;
the heating part is made of one of pure iron, pure nickel and iron alloy.
3. Tumor hyperthermia particles according to claim 1, wherein the center of gravity of the heat generating portion coincides with the center of gravity of the tumor hyperthermia particles.
4. Tumor hyperthermia particles according to claim 3, wherein the heat generating portion on a width-directional cross section of the tumor hyperthermia particles has a circular shape, and the contact portion on a width-directional cross section of the tumor hyperthermia particles has a ring shape.
5. Tumor hyperthermia particles according to claim 1, wherein the thermal vector portion comprises a thermal enhancement layer made of a thermal enhancement material and only one layer of the thermal enhancement layer is provided along the heat generating portion in a direction towards the contact portion; or,
the heat vector portion includes a heat reduction layer made of a heat reduction material, and only one layer of the heat reduction layer is provided along the heat generation portion in a direction toward the contact portion; or,
the heat vector portion includes a heat-reinforcing layer made of a heat-reinforcing material and a heat-attenuating layer made of a heat-attenuating material, and only one of the heat-reinforcing layer or the heat-attenuating layer is provided along the heat-generating portion in a direction toward the contact portion.
6. Tumor hyperthermia particles according to claim 5, wherein the material of the heat enhancing layer is the same as the material of the heat generating portion.
7. Tumor hyperthermia particles according to claim 5, wherein the material of the heat reduction layer is a ceramic material.
8. Tumor hyperthermia particles according to claim 5, wherein the thickness of the heat enhancing layer or the heat attenuating layer in different directions along the heat generating portion to the contact portion is constant.
9. Particle for tumor hyperthermia according to any of claims 1 to 8, wherein the heat vector portion is coated outside the heat generating portion to isolate the contact portion from the heat generating portion.
10. Tumor hyperthermia particle according to any of claims 1 to 8, comprising a cylindrical section and hemispherical sections at both ends of the cylindrical section, the cylindrical section having a cylindrical shape and the hemispherical sections having a hemispherical shape.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114159213A (en) * | 2021-10-26 | 2022-03-11 | 北京大学（天津滨海）新一代信息技术研究院 | Particles special for thermotherapy |
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| JP2005015911A (en) * | 2003-03-28 | 2005-01-20 | Toshiba Corp | Magnetic composite material and method for producing the same |
| JP2007325850A (en) * | 2006-06-09 | 2007-12-20 | Kyushu Institute Of Technology | Microcapsule heating element for thermotherapy and its manufacturing method |
| CN101765562A (en) * | 2007-07-26 | 2010-06-30 | 国立大学法人东京工业大学 | Process for production of surface-coated inorganic particles |
| US20140046314A1 (en) * | 2012-08-09 | 2014-02-13 | Metal Industries Research & Development Centre | Electromagnetic thermotherapy needle |
| JP2014227397A (en) * | 2013-05-24 | 2014-12-08 | 独立行政法人国立高等専門学校機構 | Ferromagnetic/non-magnetic complex |
| CN105169560A (en) * | 2015-06-12 | 2015-12-23 | 郑州轻工业学院 | Device and method used for controlling magnetic nano particle heating area |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114159213A (en) * | 2021-10-26 | 2022-03-11 | 北京大学（天津滨海）新一代信息技术研究院 | Particles special for thermotherapy |
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