CN114159213A - Particles special for thermotherapy - Google Patents
Particles special for thermotherapy Download PDFInfo
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- CN114159213A CN114159213A CN202111250700.2A CN202111250700A CN114159213A CN 114159213 A CN114159213 A CN 114159213A CN 202111250700 A CN202111250700 A CN 202111250700A CN 114159213 A CN114159213 A CN 114159213A
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- thermal
- particle
- particle body
- heat
- therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0088—Radiating heat
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
Abstract
The invention relates to particles special for thermal therapy, which belongs to the field of thermal therapy and comprises a particle body, wherein the particle body comprises a thermal enhancement part and a thermal reduction part, the thermal enhancement part is used for enhancing the radiation heat of the particles, the thermal reduction part is used for reducing the radiation heat of the particles, and a separation interface is arranged at the critical position of the thermal enhancement part and the thermal reduction part. The invention has the effect of solving the problem that the direction deflection of the thermotherapy particles is easy to occur in the implantation process, which causes the positioning deviation or the position deviation after the implantation.
Description
Technical Field
The invention relates to the technical field of thermal therapy, in particular to particles special for thermal therapy.
Background
This section provides background information related to the present disclosure only and is not necessarily prior art.
Tumor hyperthermia refers to a therapeutic method for treating tumors by means of heat. The tumor therapy by the heat therapy is also a technology which is hopefully expected and has wide medical application prospect, and becomes one of effective means for the combined therapy of the tumors except for the operation, the chemotherapy and the radiotherapy. The tumor thermotherapy heats the whole or local part of a human body by using physical energy, so that the temperature of tumor tissues is raised to an effective treatment temperature and is maintained for a certain time, and the treatment aim of apoptosis of tumor cells and no damage to the normal tissues is fulfilled by using the difference of the temperature tolerance capacities of the normal tissues and the tumor cells.
Common tumor thermotherapy techniques include ultrasound thermotherapy, microwave thermotherapy, radio frequency thermotherapy, magnetic induction thermotherapy, and the like. The magnetic induction thermotherapy is to introduce or target magnetic medium into tumor, and the magnetic medium is heated under the action of external alternating magnetic field to form shape or target and kill tumor cells.
The magnetic medium used in magnetic induction thermotherapy mainly comprises magnetic fluid and particles. The magnetic fluid presents a fluid state after being injected into a human body, and is difficult to position and shape. The problems of positioning control, temperature control and the like of the particle implanted tumor area are difficult and key problems in the existing thermotherapy technology.
The existing thermotherapy particles are usually fine cylindrical particles with a diameter of about 1 mm and a length of 3-10 mm. In order to obtain better thermotherapy temperature rise effect or better control heating boundary, the thermotherapy particles are mostly made of composite materials so as to realize vector heating effect of directional heating and directional temperature control. However, in the actual implantation process, the direction of the thermal therapy particles is easy to deflect, which causes positioning deviation, or the position deviation occurs after the implantation, which seriously affects the vector heating effect of the directional heating and the directional temperature control.
Disclosure of Invention
The invention aims to at least solve the problem that the thermotherapy particles are easy to deflect in direction during the implantation process, so that positioning deviation is caused or position deviation occurs after the implantation. The purpose is realized by the following technical scheme:
the invention provides particles special for thermal therapy, which comprise a particle body, wherein the particle body comprises a thermal enhancement part and a thermal reduction part, the thermal enhancement part is used for improving the radiation heat of the particles, the thermal reduction part is used for reducing the radiation heat of the particles, and a separation interface is arranged at the critical position of the thermal enhancement part and the thermal reduction part.
According to the particle special for thermal therapy, the thermal enhancement part and the thermal reduction part are divided on the particle body, and the boundary of the divided region is clear, so that the particle body is easy to position and not easy to generate position deviation when being implanted, and the problem that the thermal therapy particle is easy to generate direction deflection in the implantation process to cause positioning deviation or generate position deviation after being implanted is solved.
In addition, the particles dedicated to hyperthermia according to the present invention may also have the following additional technical features:
in some embodiments of the invention, the vertical cross-section of the particle body is arranged in an ellipse, and the heat enhancing portion and the heat reducing portion are disposed on both sides of a major axis and/or a minor axis of the ellipse.
In some embodiments of the present invention, the two side heads of the particle body with the elliptical vertical cross section are provided with chamfers.
In some embodiments of the present invention, the vertical cross-section of the particle body is arranged in a polygon, and the heat reinforcing portion and the heat reducing portion are disposed on both sides of the polygon.
In some embodiments of the invention, the tips and edges of the polygons are chamfered.
In some embodiments of the invention, the particle body is divided into a plurality of regions that are not uniform, the plurality of regions being the thermal enhancement portion and the thermal reduction portion, respectively.
In some embodiments of the invention, the heat enhancement portion is provided with a first mark and the heat reduction portion is provided with a second mark.
Drawings
Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. Also, like parts are designated by like reference numerals throughout the drawings. In the drawings:
FIG. 1 is a schematic diagram of a particle body of the present application having an elliptical vertical cross-section;
fig. 2 is a structural diagram of the particle body of the present application in which the vertical cross section is polygonal.
Reference numerals:
100. a particle body; 10. a heat-reinforcing portion; 20. a heat-reducing portion; 30. chamfering; 40. an axis of symmetry.
Detailed Description
Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. While exemplary embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.
It is to be understood that the terminology used herein is for the purpose of describing particular example embodiments only, and is not intended to be limiting. As used herein, the singular forms "a", "an" and "the" may be intended to include the plural forms as well, unless the context clearly indicates otherwise. The terms "comprises," "comprising," "including," and "having" are inclusive and therefore specify the presence of stated features, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, and/or groups thereof. The method steps, processes, and operations described herein are not to be construed as necessarily requiring their performance in the particular order described or illustrated, unless specifically identified as an order of performance. It should also be understood that additional or alternative steps may be used.
Although the terms first, second, third, etc. may be used herein to describe various elements, components, regions, layers and/or sections, these elements, components, regions, layers and/or sections should not be limited by these terms. These terms may be only used to distinguish one element, component, region, layer or section from another region, layer or section. Terms such as "first," "second," and other numerical terms when used herein do not imply a sequence or order unless clearly indicated by the context. Thus, a first element, component, region, layer or section discussed below could be termed a second element, component, region, layer or section without departing from the teachings of the example embodiments.
For convenience of description, spatially relative terms, such as "inner", "outer", "lower", "below", "upper", "above", and the like, may be used herein to describe one element or feature's relationship to another element or feature as illustrated in the figures. Such spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "below" or "beneath" other elements or features would then be oriented "above" or "over" the other elements or features. Thus, the example term "below … …" can include both an orientation of above and below. The device may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.
As shown in fig. 1 to 2, according to an embodiment of the present invention, there is provided a particle dedicated for thermal therapy, including a particle body 100, the particle body 100 includes a thermal enhancement part 10 and a thermal reduction part 20, the thermal enhancement part 10 is used for increasing a radiation heat of the particle, the thermal reduction part 20 is used for reducing the radiation heat of the particle, and the thermal enhancement part 10 and the thermal reduction part 20 have a distinct separation interface and are not easily deflected.
Specifically, the particle body 100 includes a thermal enhancement portion 10 and a thermal reduction portion 20 as a portion capable of enhancing or reducing heat radiated outward by the particle, wherein the material of the thermal enhancement portion 10 is a material capable of enhancing a magnetic field to increase heat radiated outward by the particle body 100, such as iron alloy and the like; the material of the heat-weakened portion 20 is a material that can weaken a magnetic field or perform a heat insulation function, so as to reduce the heat radiated from the particle body 100, such as a ceramic material. It should be noted that in other embodiments, one skilled in the art may select suitable materials for the thermal enhancement portion 10 and the thermal reduction portion 20, which are not further limited in this application.
It should be noted that the thermal enhancement unit 10 and the thermal reduction unit 20 have distinct region division boundaries on the particle body 100, so that in the process of implanting the particle body 100 into the tumor, the division of different functional regions of the particle body 100 can be determined by the division boundaries, and the particle body 100 can be implanted into a designated position in the tumor by a specific instrument according to the functions of the different functional regions, thereby avoiding the position of the particle body 100 from shifting in the tumor during or after implantation. Meanwhile, the controllability of the amount of heat radiated outward from the particle body 100 can be improved by the clear region division.
It is to be understood that the thermal enhancement section 10 may have one or more thermal enhancement materials, and by the cooperation of the multiple thermal enhancement materials, a more diverse and rich variation of thermal field shape and temperature rise of the particle body 100 can be achieved. Similarly, the thermal reduction part 20 may also include one or more thermal reduction materials, and by combining a plurality of thermal reduction materials, more various and abundant thermal field forms and temperature rise changes of the particle body 100 can be realized.
According to the particle special for thermal therapy, the thermal enhancement part 10 and the thermal reduction part 20 are divided on the particle body 100, and the boundary of the divided region is defined, so that the particle body 100 is easy to position during implantation and is not easy to generate position deviation, and the problems that the direction of the thermal therapy particle is easy to deflect during the implantation process, and the positioning deviation or the position deviation occurs after the implantation are solved. Meanwhile, boundary segmentation and functional partitioning which is not easy to deflect are carried out on the particle body 100, so that vector marking of the particle body 100 and load processing of materials are facilitated. And the doctor can conveniently and accurately position the particle body 100 according to the heating vector performance requirement of the medical plan when the particle body 100 is implanted.
In some embodiments of the present invention, further, the adjacent dividing interfaces of the thermal enhancement portion 10 and the thermal reduction portion 20 are not overlapped. The thermal enhancement portion 10 and the thermal reduction portion 20 having a definite boundary on the particle body 100 are not overlapped or overlapped with each other at their adjacent boundaries, thereby further improving controllability of the amount of heat radiated from the particle body 100 to the outside.
In some embodiments of the present invention, as shown in fig. 1, the vertical cross-section of the particle body 100 is disposed in an elliptical shape, and the heat reinforcing part 10 and the heat reducing part 20 are disposed at both sides of the major axis and/or the minor axis of the elliptical shape. Specifically, the vertical cross section of the particle body 100 is formed in an elliptical shape, and the major axis of the elliptical shape is L1-0.8 mm, and the minor axis thereof is L2-0.7 mm. The particle body 100 is divided into two parts having a regular and identical structure, one part being the heat-reinforcing part 10 and the other part being the heat-weakening part 20, with the major axis and/or the minor axis of the ellipse being taken as a dividing line. Dividing the particle body 100 into regular shapes can further improve the controllability of the amount of heat radiated from the particle body 100 to the outside.
In some embodiments of the present invention, further, the two side heads of the particle body 100 with the oval vertical cross-section are provided with chamfers 30. Specifically, the axial length of the particle body 100 is set to 3 to 15mm, the head portions of both sides of the particle body 100 having an elliptical vertical cross section are rounded, and the chamfer 30R is set to 0.2mm, so that the particle body 100 has a smooth outer contour. In specific implementation, the smooth outer contour can reduce the risk that the particle body 100 punctures a tumor membrane after being implanted into a tumor, ensure the controllability during implantation and improve the guarantee for the life of a patient.
In some embodiments of the present invention, as shown in fig. 2, the vertical cross-section of the particle body 100 is arranged in a polygon, and the heat reinforcing part 10 and the heat reducing part 20 are partially disposed at both sides of the polygon.
In some embodiments of the invention, further, the tips and edges of the polygons are chamfered 30.
Specifically, the outer shape of the particle body 100 may be configured to be polygonal, such as triangular, rectangular, hexagonal, and the like. In the present embodiment, the particle body 100 is divided into two parts having a regular and identical structure, one part being the heat-reinforcing part 10 and the other part being the heat-reducing part 20, with the polygonal symmetry axis 40 being taken as a dividing line. Dividing the particle body 100 into regular shapes can further improve the controllability of the amount of heat radiated from the particle body 100 to the outside. Meanwhile, the tips and edges of the particle body 100 having a polygonal vertical cross-section are chamfered 30, and the tips and edges are rounded to smooth the outer profile of the particle body 100. In specific implementation, the smooth outer contour can reduce the risk that the particle body 100 punctures a tumor membrane after being implanted into a tumor, ensure the controllability during implantation and improve the guarantee for the life of a patient. In other embodiments, the outer shape of the particle body 100 may be configured to have an elliptical cross-section on one side, a polygonal cross-section on one side, or other shapes, so as to increase the diversity of the particle body 100, but is not limited thereto.
In some embodiments of the present invention, the particle body 100 is divided into a plurality of regions that are not uniform, the plurality of regions being the thermal enhancement region 10 and the thermal reduction region 20, respectively. Specifically, the particle body 100 is divided into several regions that are not uniform, the different regions are the heat reinforcing portion 10 or the heat reducing portion 20, respectively, and the adjacent heat reinforcing portion 10 and the heat reducing portion 20 have distinct dividing boundaries. The heat reinforcing parts 10 of the plurality of regions can further increase the amount of radiation heat of the particles, and the heat reducing parts 20 of the plurality of regions can further reduce the amount of radiation heat of the particles, that is, can further improve the controllability of the particle body 100.
In some embodiments of the present invention, the heat enhancement portion 10 is provided with a first marking and the heat reduction portion 20 is provided with a second marking. Specifically, in one implementation, the body 100 of the implant is used in conjunction with an implanter that is closely matched to the body 100 of the particle and that is capable of paired labeling of different functional regions (heat-enhanced portion 10 and heat-reduced portion 20) for implantation into a tumor. For example, color marking, and differentiating the heat enhanced portion 10 and the heat reduced portion 20 with different colors ensures that the body of the seed 100 is implanted without malfunction and the body of the seed 100 is not deflected in the implanter. And the implanter which is strictly matched with the particle body 100 and can carry out pairing marking on different functional partitions can optimize the implantation process to the maximum extent, is convenient for the accurate operation of a doctor and improves the implantation success rate of the particle body 100.
In some embodiments of the invention, the outer surface of particle body 100 may also be coated with a protective jacket layer. The protective layer is a portion of the particle body 100 that is in direct contact with a human body, and generally, the material of the protective layer is a human body-compatible material. The protective layer is coated outside the particle body 100 to isolate the particle body 100 from the human body, so that the particle body 100 can be effectively prevented from being in direct contact with the human body, and normal cell tissues around the tumor tissues can be protected while the tumor tissues are killed by heating treatment.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (7)
1. The particle special for thermal therapy is characterized by comprising a particle body, wherein the particle body comprises a thermal enhancement part and a thermal reduction part, the thermal enhancement part is used for improving the radiation heat of the particle, the thermal reduction part is used for reducing the radiation heat of the particle, and a separation interface is arranged at the critical position of the thermal enhancement part and the thermal reduction part.
2. A particle for use in therapy as claimed in claim 1, wherein the particle body has an elliptical vertical cross-section, and the heat-reinforcing part and the heat-reducing part are disposed on both sides of the major axis and/or the minor axis of the elliptical shape.
3. A particle for exclusive use as claimed in claim 2, wherein both side heads of the particle body having an elliptical vertical cross section are provided with chamfers.
4. A particle for use in therapy as claimed in claim 1, wherein the particle body has a polygonal vertical cross-section, and the heat reinforcing part and the heat reducing part are disposed at both sides of the polygonal shape.
5. A particle dedicated for thermal therapy as claimed in claim 3, wherein the tips and edges of the polygon are chamfered.
6. A particle for exclusive use in thermal therapy as claimed in claim 1, wherein the particle body is divided into a plurality of regions which are not uniform, the plurality of regions being the thermal enhancement portion and the thermal reduction portion, respectively.
7. A particle dedicated for thermal therapy as claimed in claim 1, wherein the thermal enhancement section is provided with a first marker and the thermal reduction section is provided with a second marker.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111250700.2A CN114159213A (en) | 2021-10-26 | 2021-10-26 | Particles special for thermotherapy |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111250700.2A CN114159213A (en) | 2021-10-26 | 2021-10-26 | Particles special for thermotherapy |
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| CN114159213A true CN114159213A (en) | 2022-03-11 |
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| CN202111250700.2A Pending CN114159213A (en) | 2021-10-26 | 2021-10-26 | Particles special for thermotherapy |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101284161A (en) * | 2008-05-27 | 2008-10-15 | 同济大学 | Microparticle with double function of radiotheraphy and thermotherapy and preparation method thereof |
| CN103736201A (en) * | 2013-12-31 | 2014-04-23 | 原子高科股份有限公司 | Radioactive particle chain |
| CN104083777A (en) * | 2014-07-11 | 2014-10-08 | 华南师范大学 | Upconversion composite nano-material as well as preparation method and application thereof |
| US20160361417A1 (en) * | 2015-06-15 | 2016-12-15 | Boston Scientific Scimed, Inc. | Devices and methods for therapeutic heat treatment |
| WO2017188725A1 (en) * | 2016-04-29 | 2017-11-02 | 서울대학교산학협력단 | Thermotherapy device |
| CN108057173A (en) * | 2017-12-08 | 2018-05-22 | 丰润（泉州）健康科技有限公司 | A kind of physical therapy device and its processing technology |
| CN110292632A (en) * | 2019-07-03 | 2019-10-01 | 北京大学第三医院（北京大学第三临床医学院） | A kind of tumor thermotherapy particle |
| CN213407506U (en) * | 2020-03-20 | 2021-06-11 | 原子高科股份有限公司 | Medical particle with dual functions of brachytherapy and magnetic induction thermotherapy |
-
2021
- 2021-10-26 CN CN202111250700.2A patent/CN114159213A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101284161A (en) * | 2008-05-27 | 2008-10-15 | 同济大学 | Microparticle with double function of radiotheraphy and thermotherapy and preparation method thereof |
| CN103736201A (en) * | 2013-12-31 | 2014-04-23 | 原子高科股份有限公司 | Radioactive particle chain |
| CN104083777A (en) * | 2014-07-11 | 2014-10-08 | 华南师范大学 | Upconversion composite nano-material as well as preparation method and application thereof |
| US20160361417A1 (en) * | 2015-06-15 | 2016-12-15 | Boston Scientific Scimed, Inc. | Devices and methods for therapeutic heat treatment |
| WO2017188725A1 (en) * | 2016-04-29 | 2017-11-02 | 서울대학교산학협력단 | Thermotherapy device |
| CN108057173A (en) * | 2017-12-08 | 2018-05-22 | 丰润（泉州）健康科技有限公司 | A kind of physical therapy device and its processing technology |
| CN110292632A (en) * | 2019-07-03 | 2019-10-01 | 北京大学第三医院（北京大学第三临床医学院） | A kind of tumor thermotherapy particle |
| CN213407506U (en) * | 2020-03-20 | 2021-06-11 | 原子高科股份有限公司 | Medical particle with dual functions of brachytherapy and magnetic induction thermotherapy |
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