CN110251720A - Liquid dressing and preparation method thereof - Google Patents
Liquid dressing and preparation method thereof Download PDFInfo
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- CN110251720A CN110251720A CN201910662282.4A CN201910662282A CN110251720A CN 110251720 A CN110251720 A CN 110251720A CN 201910662282 A CN201910662282 A CN 201910662282A CN 110251720 A CN110251720 A CN 110251720A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
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- General Health & Medical Sciences (AREA)
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Abstract
The invention belongs to surface of a wound nursing fields, and in particular to a kind of liquid dressing and preparation method thereof.The invention proposes a kind of liquid dressings, including following component according to the mass fraction: I 5-12 parts of film forming agent, II 0-8 parts of film forming agent, 50-90 parts of volatile solvent, 1-10 parts of plasticizer；The liquid dressing has the characteristics that ingredient safety, skin sense are comfortable, and the preparation method of the liquid dressing is simple, cost is relatively low, is suitable for industrial application.
Description
Technical field
The invention belongs to surface of a wound nursing fields, and in particular to a kind of liquid dressing and preparation method thereof.
Background technique
In daily life, Dermal skin damage is very common, including scratch, scuffing, scald and burn etc..Traditional wound
/ wound cares the product such as gauze can be pasted, that there are foreign body sensations is strong, is easy the disadvantages of easy to fall off after sticking together, get wet with wound.
In the 1960s, wet union theory is pointed out, the migration velocity of epidermal cell is can be improved in moist environment, makes to create
Face healing time is shorter compared with the time that the surface of a wound in stemness environment is formed a scab；In addition, moist environment can promote Porcine HGF with
Receptor combines, and is conducive to keep surface of a wound cell activity, wound healing.Based on wet union theory, for shallow skin
The liquid dressing of skin damage becomes research hotspot in recent years.
CN201010233179.7 discloses a kind of liquid bandage, while addition forms a film moisturizer, passes through addition
The plant extracts ingredient such as five tastes rattan, Resina Draconis, olibanum, myrrh, Radix Notoginseng plays the role of that the surface of a wound is protected to promote Wound healing.
Wherein plant extracts action principle is complicated, easily causes the adverse reactions such as skin irritatin, allergy in actual use.
CN201010248217.6 discloses a kind of antibacterial biological dressing, by adding in Polyvinyl acetal reacts
Enter chitosan/polyvinyl alcohol blended liquid and carry the SiO 2 powder of silver, is made containing nano silver/nano silica antibacterial
Biological dressing.It joined the dehydrated alcohol and formaldehyde of high level in the technical solution, it is higher to skin irritation, and influence to make
With experience；Silver-loaded silica, higher cost have been used simultaneously.
In conclusion researching and developing a kind of ingredient safety, using skin sense is comfortable, cost is relatively low and the simple liquid of preparation method applies
Material, is very necessary.
Summary of the invention
Aiming at the problems existing in the prior art, the invention proposes a kind of liquid dressing and preparation method thereof, the liquid
Body dressing has the characteristics that ingredient safety, skin sense are comfortable, and the preparation method of the liquid dressing is simple, cost is relatively low, is suitable for producing
Industry application.
In order to achieve the above object, the present invention proposes that a kind of liquid dressing, the liquid dressing include according to the mass fraction
Following component: I 5-12 parts of film forming agent, II 0-8 parts of film forming agent, 50-90 parts of volatile solvent, 1-10 parts of plasticizer.
Further, the film forming agent I is selected from Pioloform, polyvinyl acetal.
Preferably, the Pioloform, polyvinyl acetal be selected from one of polyvinyl formal acetal, polyvinyl butyral or
It is a variety of.
Further, the film forming agent II is selected from ethyl cellulose, nitrocellulose, polyvinylpyrrolidone, poly- diformazan
One of radical siloxane, polyacrylic resin are a variety of；The volatile solvent is selected from ethyl alcohol, isopropanol, poly dimethyl silicon
One of oxygen alkane, poly- hexamethyldisiloxane, isooctane, acetone, ether are a variety of；The plasticizer is selected from citron triethylenetetraminehexaacetic acid
Ester, tributyl citrate, isopropyl palmitate, glyceryl triacetate, repefral, diethyl phthalate,
One of dibutyl phthalate, dibutyl sebacate are a variety of.
Preferably, the liquid dressing further includes softening agent and auxiliary agent.
Further, mass fraction of the softening agent in the liquid dressing is 0-10 parts, and the auxiliary agent is described
Mass fraction in liquid dressing is 2-5 parts.
Further, the softening agent is glycerol；The auxiliary agent is selected from one of solid paraffin, atoleine or more
Kind.
The present invention also provides a kind of preparation methods of liquid dressing, comprising the following steps:
(1) Agitation Tank is added in the property of will volatilize solvent, and 20-35 DEG C, 500-700r/min stirring 5-20min are uniformly mixed solvent；
(2) Agitation Tank is warming up to 20-50 DEG C, and 500-700r/min is persistently stirred, into solvent made from step (1), be added at
Film I is uniformly mixed；
(3) 20-35 DEG C, under the conditions of 500-700r/min, it is slowly added to film forming agent II into mixed liquor made from step (2), with
800-1100r/min continues to stir 1-3h, is uniformly mixed；
(4) 20-35 DEG C, under the conditions of 500-700r/min, into mixed liquor made from step (3), plasticizer, softening are sequentially added
Agent, auxiliary agent are uniformly mixed, 800-1100r/min, are stirred 30-60min, are completely dissolved mixed liquor；20min is stood, to bubble
It completely disappears, it is filling to get the liquid dressing.
The present invention can be realized the reason of above-mentioned purpose and be:
Pioloform, polyvinyl acetal has preferable film forming, higher tensile strength, the high grade of transparency and stronger caking property, while resistance to
It is illumination, heat-resisting, cold-resistant, there is excellent impact resistance, institute is soft, flexible at film, has preferable waterproofness.Ethyl
Cellulose has excellent flexibility and thermal stability, resists cold, resistance to moisture absorption, can be with various kinds of resin, plasticizer compatibility, and property is steady
It is fixed.The solubility of nitrocellulose in organic solvent is higher, and elasticity and rub resistance are preferable after film forming.Polyvinylpyrrolidone
It is that one kind had not only been dissolved in water but also had been dissolved in most of organic solvent, toxicity is low, has excellent solubility property and physiological compatibility.Poly- two
Gas permeability is strong after methylsiloxane film forming, has preferable permeability and uvioresistant effect.Polyacrylic resin is in water
It can be dispersed into lotion rapidly, it is harmless as film forming agent, while having the characteristics that transparency is high, corrosion-resistant, resistant to pollution.
Ethanol soluble dissolves many substances at the same time as solvent in water and most organic solvents, in addition, ethyl alcohol also has
There is stronger bactericidal effect.Most organic solvents such as isopropanol is water-soluble, alcohol, ether, benzene, chloroform, there is lipophilicity substance
Excellent dissolving power.Dimethyl silicone polymer colorless and odorless has preferable waterproofness and heat resistance, can be formed in skin surface
Protective film with waterproofness, while there is stronger anti-ultraviolet property, it under ultraviolet light will not oxidation deterioration.Poly- hexamethyl
Disiloxane is not soluble in water, dissolves in a variety of organic solvents, can play the moisture-proof effect of hydrophobic.Isooctane is not soluble in water, is dissolved in
Ether, benzene,toluene,xylene, chloroform, carbon disulfide, four nitric sulfids etc. are a kind of organic solvents that property is stable.Acetone, nothing
Color transparency liquid, the organic solvents such as soluble easily in water and methanol, ethyl alcohol, ether, chloroform, pyridine.Ether, colourless transparent liquid, easily
Volatilization, is dissolved in low-carbon alcohols, benzene, chloroform, petroleum ether and oils, is slightly soluble in water, and it is fine to can be used as natural resin, synthetic resin, nitrification
The high-quality solvent of dimension etc..
Triethyl citrate is nontoxic, dissolves in most of organic solvents, with most of celluloses, polyvinyl chloride, poly-vinegar acid
Vinyl etc. has good compatibility, can be used as the plasticizer of the thermoplastic resins such as cellulose family, vinyl-based.Citric acid
Tributyl is not soluble in water, is dissolved in methanol, acetone and other organic solvent, low volatility, good compatibility with resin, high plasticizing efficiency.
Isopropyl palmitate is not soluble in water and glycerol, dissolves in alcohol, ether, property is stablized, not oxidizable.Glyceryl triacetate is slightly dissolved in
Water is dissolved in most organic solvents such as ethyl alcohol, ether, benzene, chloroform, can be used as plasticizer, play the effect for increasing product ductility.
Repefral, diethyl phthalate, dibutyl phthalate are stable organic molten of a kind of chemical property
Agent has excellent dissolubility, dispersibility, adherence and waterproofness, can be used as the plasticizer of various kinds of resin, energy and multiple fiber
Plain resin, rubber, vinylite are compatible, have no toxic side effect to human skin mucous membrane.Dibutyl sebacate can be with most of trees
Rouge and synthetic rubber are compatible, nontoxic, can be used as plasticizer.
Glycerol has stronger water imbibition, can play the role of increasing product flexibility, in the technical scheme as soft
Agent uses.Solid paraffin, atoleine have the characteristics that lipophilic, adhesion is good, absorbability is good, can be used as thickener, adjust
The viscosity of the aqueous solution of whole liquid medicine or drug.
Liquid dressing prepared by the present invention, ingredient safety, institute is at film highly transparent, convenient for the observation surface of a wound；Have after film forming
There are excellent waterproofness, flexibility and gas permeability, can effectively obstruct bacterial invasion, there is good sterilization, promoting healing ability；
Liquid dressing of the present invention, preparation method is simple, low in cost, is suitable for industrial application.
Detailed description of the invention
Fig. 1 a- Fig. 1 c is the 7 days healing states of rat back wound not processed.
Fig. 1 d- Fig. 1 f is the 7 days healing states of rat back wound for making liquid dressing processing prepared with embodiment 3.
Fig. 2 a- Fig. 2 d is the waterproofness verifying of liquid dressing prepared by embodiment 1.
Specific embodiment
Carry out the technical solution that the present invention will be described in detail below by specific embodiment.
Embodiment 1
The present embodiment provides a kind of liquid dressings, including the following component according to mass fraction meter:
Film forming agent I: 5 parts of polyvinyl formal acetal；
Film forming agent II: 2 parts of polyvinylpyrrolidone, 2 parts of dimethyl silicone polymer；
Volatile solvent: 50 parts of ethyl alcohol；
Plasticizer: 0.5 part of triethyl citrate, 0.5 part of tributyl citrate；
Auxiliary agent: 2 parts of solid paraffin.
The method for preparing the liquid dressing:
(1) Agitation Tank is added in the property of will volatilize solvent, and 30 DEG C, 700r/min stirring 10min are uniformly mixed solvent；
(2) Agitation Tank is warming up to 40 DEG C, and 700r/min is persistently stirred, and into solvent made from step (1), film forming agent I is added, mixes
It closes uniform；
(3) 30 DEG C, under the conditions of 700r/min, it is slowly added to film forming agent II into mixed liquor made from step (2), with 1000r/
Min continues to stir 1.5h, is uniformly mixed；
(4) 30 DEG C, under the conditions of 700r/min, into mixed liquor made from step (3), plasticizer, auxiliary agent are sequentially added, mixing is equal
Even, 1100r/min stirs 30min, is completely dissolved mixed liquor；20min is stood, is completely disappeared to bubble, it is filling to get institute
State liquid dressing.
Embodiment 2
The present embodiment provides a kind of liquid dressings, including the following component according to mass fraction meter:
Film forming agent I: 5 parts of polyvinyl butyral；
Film forming agent II: 4 parts of ethyl cellulose, 2 parts of nitrocellulose, 2 parts of polyvinylpyrrolidone；
Volatile solvent: 10 parts of ethyl alcohol, 10 parts of isopropanol, 10 parts of dimethyl silicone polymer, 5 parts of poly- hexamethyldisiloxane are different
5 parts of octane, 10 parts of acetone, 5 parts of ether；
Plasticizer: 2 parts of triethyl citrate, 1 part of tributyl citrate, 1 part of isopropyl palmitate, 1 part of glyceryl triacetate, adjacent
2 parts of rutgers, 1 part of diethyl phthalate, 1 part of dibutyl phthalate, 1 part of dibutyl sebacate；
Softening agent: 2 parts of glycerol；
Auxiliary agent: 5 parts of atoleine.
The method for preparing the liquid dressing:
(1) Agitation Tank is added in the property of will volatilize solvent, and 35 DEG C, 600r/min stirring 10min are uniformly mixed solvent；
(2) Agitation Tank be warming up to 50 DEG C, 600r/min persistently stir, into solvent made from step (1), be added film forming agent I, mix
It closes uniform；
(3) 35 DEG C, under the conditions of 600r/min, film forming agent II is slowly added into mixed liquor made from step (2), with 1000r/
Min continues to stir 3h, is uniformly mixed；
(4) 35 DEG C, under the conditions of 600r/min, into mixed liquor made from step (3), sequentially add plasticizer, softening agent, help
Agent is uniformly mixed, 800r/min, is stirred 50min, is completely dissolved mixed liquor；20min is stood, is completely disappeared to bubble, is filled
Dress is to get the liquid dressing.
Embodiment 3
The present embodiment provides a kind of liquid dressings, including the following component according to mass fraction meter:
Film forming agent I: 10 parts of polyvinyl butyral；
Volatile solvent: 20 parts of ethyl alcohol, 40 parts of isopropanol, 20 parts of poly- hexamethyldisiloxane；
Plasticizer: 5 parts of triethyl citrate；
Softening agent: 3 parts of glycerol；
Auxiliary agent: 1 part of solid paraffin, 1 part of atoleine.
The method for preparing the liquid dressing:
(1) Agitation Tank is added in the property of will volatilize solvent, and 20 DEG C, 500r/min stirring 20min are uniformly mixed solvent；
(2) Agitation Tank be warming up to 25 DEG C, 600r/min persistently stir, into solvent made from step (1), be added film forming agent I, mix
It closes uniform；
(3) 20 DEG C, under the conditions of 500r/min, into mixed liquor made from step (2), sequentially add plasticizer, softening agent, help
Agent is uniformly mixed, 1000r/min, is stirred 60min, is completely dissolved mixed liquor；20min is stood, is completely disappeared to bubble, is filled
Dress is to get the liquid dressing.
Embodiment 4
The present embodiment provides a kind of liquid dressings, including the following component according to mass fraction meter:
Film forming agent I: 12 parts of polyvinyl formal acetal；
Film forming agent II: 2 parts of ethyl cellulose, 2 parts of polyvinylpyrrolidone, 2 parts of dimethyl silicone polymer, polyacrylic resin 2
Part；
Volatile solvent: 10 parts of ethyl alcohol, 30 parts of isopropanol, 5 parts of dimethyl silicone polymer, 5 parts of poly- hexamethyldisiloxane are different pungent
5 parts of alkane, 5 parts of acetone, 5 parts of ether；
Plasticizer: 4 parts of tributyl citrate, 2 parts of glyceryl triacetate, 4 parts of diethyl phthalate；
Softening agent: 8 parts of glycerol；
Auxiliary agent: 4 parts of solid paraffin, 1 part of atoleine.
The method for preparing the liquid dressing:
(1) Agitation Tank is added in the property of will volatilize solvent, and 35 DEG C, 700r/min stirring 15min are uniformly mixed solvent；
(2) Agitation Tank be warming up to 40 DEG C, 700r/min persistently stir, into solvent made from step (1), be added film forming agent I, mix
It closes uniform；
(3) 35 DEG C, under the conditions of 700r/min, film forming agent II is slowly added into mixed liquor made from step (2), with 1000r/
Min continues to stir 1h, is uniformly mixed；
(4) 35 DEG C, under the conditions of 700r/min, into mixed liquor made from step (3), sequentially add plasticizer, softening agent, help
Agent is uniformly mixed, 1000r/min, is stirred 40min, is completely dissolved mixed liquor；20min is stood, is completely disappeared to bubble, is filled
Dress is to get the liquid dressing.
Embodiment 5
The present embodiment provides a kind of liquid dressings, including the following component according to mass fraction meter:
Film forming agent I: 12 parts of polyvinyl butyral；
Film forming agent II: 4 parts of ethyl cellulose, 4 parts of dimethyl silicone polymer；
Volatile solvent: 60 parts of ethyl alcohol, 5 parts of isopropanol, 5 parts of dimethyl silicone polymer, 5 parts of poly- hexamethyldisiloxane are different pungent
5 parts of alkane, 5 parts of acetone, 5 parts of ether；
Plasticizer: 1 part of triethyl citrate, 1 part of tributyl citrate, 1 part of Isopropyl citrate, 1 part of glyceryl triacetate, adjacent
1 part of rutgers, 1 part of diethyl phthalate, 1 part of dibutyl phthalate, 1 part of dibutyl sebacate；
Softening agent: 10 parts of glycerol；
Auxiliary agent: 2 parts of solid paraffin, 2 parts of atoleine.
The method for preparing the liquid dressing:
(1) Agitation Tank is added in the property of will volatilize solvent, and 35 DEG C, 700r/min stirring 15min are uniformly mixed solvent；
(2) Agitation Tank be warming up to 40 DEG C, 700r/min persistently stir, into solvent made from step (1), be added film forming agent I, mix
It closes uniform；
(3) 35 DEG C, under the conditions of 700r/min, film forming agent II is slowly added into mixed liquor made from step (2), with 1000r/
Min continues to stir 1h, is uniformly mixed；
(4) 35 DEG C, under the conditions of 700r/min, into mixed liquor made from step (3), sequentially add plasticizer, softening agent, help
Agent is uniformly mixed, 1000r/min, is stirred 40min, is completely dissolved mixed liquor；20min is stood, is completely disappeared to bubble, is filled
Dress is to get the liquid dressing.
Validity, waterproofness verifying are carried out to liquid dressing prepared by embodiment 1 to embodiment 5, it is as a result as follows.
(1) promote healing ability verifying
Validation verification is carried out using zoopery.
Experimental material:, being divided into 6 groups by male SD rat 12, small group # be respectively as follows: 1 group, 2 groups, 3 groups, 4 groups, 5 groups,
6 groups.
Experimental method:
Experimental rat back hair is removed, in the damage of back production length 2cm or so；It is damaged in 1 group to 5 groups rat back
Place, reference numeral smear the liquid dressing that embodiment 1 is prepared to embodiment 5, smear daily primary；6 groups of rat back damages are not
It processes, as control；Experimental rat single cage is fed, and observes rat back wound healing situation respectively within experiment the 3rd day, 7 days, and
It is recorded.
Final experimental result is shown in Table 1.
1 liquid dressing of table promotes healing ability verification result
By taking the experiment of the promotion healing ability of embodiment 3 as an example:
The control rats back surface of a wound does not process, and such as Fig. 1 a, after experiment 3 days, the surface of a wound is obviously formed a scab, and has secretion, such as schemes
1b, after experiment 7 days, the control rats back surface of a wound heals substantially, and incrustation falls off, it is seen that obvious scar, such as Fig. 1 c；Experimental group is big
After mouse smears liquid dressing prepared by embodiment 3, film forming is obvious, such as Fig. 1 d, after experiment 3 days, the experimental rat back surface of a wound is dry,
Without infection, without secretion, such as Fig. 1 e；After experiment 7 days, the experimental rat back surface of a wound heals completely, almost without scar, such as Fig. 1 f.
Experimental result shows that the liquid dressing protection superficial wound that experimental group is prepared using embodiment 1 to embodiment 5 has
Effect promotes the healing of superficial wound, and the surface of a wound that heals is without obvious scar；And wound it is non-treated when, when 3 days after surgery materials,
The surface of a wound has apparent scar phenomenon, and it is preferable effective to illustrate that liquid dressing has the protection of shallow wound isolation from result above
Property and safety.
(2) waterproofness is verified
5 volunteers are chosen, number 1, No. 2, No. 3, No. 4, No. 5, on the inside of volunteer's forearm, choosing two pieces of areas respectively is
The skin of 2 × 2cm smears Iodophor；After Iodophor is dry, on the Iodophor surface of wherein one piece of tested skin, smear embodiment 1 to
Liquid dressing prepared by embodiment 5, the Iodophor surface of another piece of tested skin is not processed；After liquid dressing film forming, with stream
Dynamic water rinses tested skin 1min, observes tested skin surface, is verified result (being shown in Table 2).
2 liquid dressing waterproofness verification result of table
By taking the waterproofness verifying of liquid dressing prepared by embodiment 1 as an example, iodine has been smeared at elbow on the inside of volunteer's forearm
The skin of volt is test skin, and the skin of Iodophor has been smeared at palm for control, such as Fig. 2 a；It is smeared at test skin real
The liquid dressing of the preparation of example 1 is applied, compares and is not processed at skin, such as Fig. 2 b；It stands, after liquid dressing film forming, uses circulating water
Tested skin is rinsed, such as Fig. 2 c；It rinses 1min and observes tested skin conditions after moisture is killed, such as Fig. 2 d.
By above-mentioned specific embodiment and verification result it is found that liquid dressing prepared by the present invention heals with good promotion
Ability and waterproof ability, while ingredient safety, will not cause skin adverse reaction.
Above embodiments and embodiment are only used for helping to understand technical solution of the present invention, should not be used as limiting guarantor of the present invention
Protect the foundation of range.The improvement without involving an inventive effort and replace that those skilled in the art make on the basis of the present invention
It changes, each falls within protection scope of the present invention.
Claims (10)
1. a kind of liquid dressing, which is characterized in that including following component according to the mass fraction: I 5-12 parts of film forming agent, film forming
II 0-8 parts of agent, 50-90 parts of volatile solvent, 1-10 parts of plasticizer.
2. liquid dressing according to claim 1, which is characterized in that the film forming agent I is selected from Pioloform, polyvinyl acetal.
3. liquid dressing according to claim 2, which is characterized in that the Pioloform, polyvinyl acetal is selected from polyvinyl alcohol contracting first
One of acetaldehyde, polyvinyl butyral are a variety of.
4. liquid dressing according to claim 1, which is characterized in that the film forming agent II is selected from ethyl cellulose, nitrification
One of cellulose, polyvinylpyrrolidone, dimethyl silicone polymer, polyacrylic resin are a variety of.
5. liquid dressing according to claim 1, which is characterized in that the volatile solvent is selected from ethyl alcohol, isopropanol, gathers
One of dimethyl siloxane, poly- hexamethyldisiloxane, isooctane, acetone, ether are a variety of.
6. liquid dressing according to claim 1, which is characterized in that the plasticizer is selected from triethyl citrate, citron
Sour tributyl, isopropyl palmitate, glyceryl triacetate, repefral, diethyl phthalate, O-phthalic
One of dibutyl phthalate, dibutyl sebacate are a variety of.
7. liquid dressing according to claim 1, which is characterized in that the liquid dressing further includes softening agent and auxiliary agent.
8. liquid dressing according to claim 7, which is characterized in that quality of the softening agent in the liquid dressing
Number is 0-10 parts, and mass fraction of the auxiliary agent in the liquid dressing is 2-5 parts.
9. liquid dressing according to claim 8, which is characterized in that the softening agent is glycerol；The auxiliary agent is selected from solid
One of body paraffin, atoleine are a variety of.
10. the preparation method of liquid dressing as described in claim 1, which comprises the following steps:
(1) Agitation Tank is added in the property of will volatilize solvent, and 20-35 DEG C, 500-700r/min stirring 5-20min keep solvent mixing equal
It is even；
(2) Agitation Tank is warming up to 20-50 DEG C, and 500-700r/min is persistently stirred, into solvent made from step (1), be added at
Film I is uniformly mixed；
(3) 20-35 DEG C, under the conditions of 500-700r/min, it is slowly added to film forming agent II into mixed liquor made from step (2), with
800-1100r/min continues to stir 1-3h, is uniformly mixed；
(4) 20-35 DEG C, under the conditions of 500-700r/min, into mixed liquor made from step (3), plasticizer, softening are sequentially added
Agent, auxiliary agent are uniformly mixed, 800-1100r/min, are stirred 30-60min, are completely dissolved mixed liquor；20min is stood, to bubble
It completely disappears, it is filling to get the liquid dressing.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111184906A (en) * | 2020-02-19 | 2020-05-22 | 江南大学 | PVA-based liquid dressing and preparation method thereof |
| CN113181420A (en) * | 2021-05-07 | 2021-07-30 | 多能干细胞再生医学科技（广州）有限公司 | Liquid wound dressing for quickly repairing skin superficial injury and preparation method thereof |
| CN113289055A (en) * | 2021-05-25 | 2021-08-24 | 振德医疗用品股份有限公司 | Green liquid adhesive bandage with antibacterial function and preparation method thereof |
| CN114225102A (en) * | 2021-12-28 | 2022-03-25 | 浙江蓝禾医疗用品有限公司 | Liquid dressing for wound protection and preparation method thereof |
| CN114306728A (en) * | 2022-01-18 | 2022-04-12 | 人福医药集团医疗用品有限公司 | Composite film forming agent, waterproof liquid band-aid and preparation method thereof |
| US11446256B1 (en) | 2021-08-20 | 2022-09-20 | Advantice Health, Llc | Aqueous wound healing formulation |
| CN116440318A (en) * | 2023-04-25 | 2023-07-18 | 湖南省天香生物科技有限责任公司 | Liquid band-aid capable of stopping bleeding rapidly and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107050503A (en) * | 2017-03-14 | 2017-08-18 | 陕西佰傲再生医学有限公司 | Liquid Wound surface protection film and preparation method thereof |
| CN107468904A (en) * | 2017-08-24 | 2017-12-15 | 浙江医药高等专科学校 | Liquid bandage and preparation method thereof |
| CN108904876A (en) * | 2018-10-15 | 2018-11-30 | 长春艾迪尔医用科技发展有限公司 | A kind of liquid wound dressing and preparation method thereof |
-
2019
- 2019-07-22 CN CN201910662282.4A patent/CN110251720A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107050503A (en) * | 2017-03-14 | 2017-08-18 | 陕西佰傲再生医学有限公司 | Liquid Wound surface protection film and preparation method thereof |
| CN107468904A (en) * | 2017-08-24 | 2017-12-15 | 浙江医药高等专科学校 | Liquid bandage and preparation method thereof |
| CN108904876A (en) * | 2018-10-15 | 2018-11-30 | 长春艾迪尔医用科技发展有限公司 | A kind of liquid wound dressing and preparation method thereof |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111184906A (en) * | 2020-02-19 | 2020-05-22 | 江南大学 | PVA-based liquid dressing and preparation method thereof |
| CN111184906B (en) * | 2020-02-19 | 2020-12-29 | 江南大学 | PVA-based liquid dressing and preparation method thereof |
| CN113181420A (en) * | 2021-05-07 | 2021-07-30 | 多能干细胞再生医学科技（广州）有限公司 | Liquid wound dressing for quickly repairing skin superficial injury and preparation method thereof |
| CN113181420B (en) * | 2021-05-07 | 2022-03-11 | 多能干细胞再生医学科技（广州）有限公司 | Liquid wound dressing for quickly repairing skin superficial injury and preparation method thereof |
| CN113289055A (en) * | 2021-05-25 | 2021-08-24 | 振德医疗用品股份有限公司 | Green liquid adhesive bandage with antibacterial function and preparation method thereof |
| US11446256B1 (en) | 2021-08-20 | 2022-09-20 | Advantice Health, Llc | Aqueous wound healing formulation |
| US11844869B2 (en) | 2021-08-20 | 2023-12-19 | Advantice Health, Llc | Aqueous wound healing formulation |
| CN114225102A (en) * | 2021-12-28 | 2022-03-25 | 浙江蓝禾医疗用品有限公司 | Liquid dressing for wound protection and preparation method thereof |
| CN114306728A (en) * | 2022-01-18 | 2022-04-12 | 人福医药集团医疗用品有限公司 | Composite film forming agent, waterproof liquid band-aid and preparation method thereof |
| CN116440318A (en) * | 2023-04-25 | 2023-07-18 | 湖南省天香生物科技有限责任公司 | Liquid band-aid capable of stopping bleeding rapidly and preparation method thereof |
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