CN110231472A - A kind of chemical illumination immunity analysis instrument - Google Patents
A kind of chemical illumination immunity analysis instrument Download PDFInfo
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- CN110231472A CN110231472A CN201810183818.XA CN201810183818A CN110231472A CN 110231472 A CN110231472 A CN 110231472A CN 201810183818 A CN201810183818 A CN 201810183818A CN 110231472 A CN110231472 A CN 110231472A
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- 238000004458 analytical method Methods 0.000 title claims abstract description 33
- 239000000126 substance Substances 0.000 title claims abstract description 31
- 238000005286 illumination Methods 0.000 title claims abstract description 29
- 230000036039 immunity Effects 0.000 title claims abstract description 29
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 65
- 238000005070 sampling Methods 0.000 claims abstract description 61
- 238000004140 cleaning Methods 0.000 claims abstract description 46
- 238000005119 centrifugation Methods 0.000 claims abstract description 23
- 238000011534 incubation Methods 0.000 claims abstract description 15
- 238000007689 inspection Methods 0.000 claims abstract description 9
- 230000003287 optical effect Effects 0.000 claims abstract description 8
- 230000007246 mechanism Effects 0.000 claims description 53
- 238000006243 chemical reaction Methods 0.000 claims description 47
- 238000002347 injection Methods 0.000 claims description 23
- 239000007924 injection Substances 0.000 claims description 23
- 238000010438 heat treatment Methods 0.000 claims description 9
- 238000005213 imbibition Methods 0.000 claims description 4
- 238000001514 detection method Methods 0.000 abstract description 11
- 238000003745 diagnosis Methods 0.000 abstract description 6
- 210000004369 blood Anatomy 0.000 abstract description 5
- 239000008280 blood Substances 0.000 abstract description 5
- 239000006249 magnetic particle Substances 0.000 abstract description 5
- 238000005259 measurement Methods 0.000 abstract description 5
- 230000008901 benefit Effects 0.000 abstract description 3
- 230000002860 competitive effect Effects 0.000 abstract description 2
- 238000013461 design Methods 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 6
- 238000012360 testing method Methods 0.000 description 5
- 230000006870 function Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000008450 motivation Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
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- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
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- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
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Abstract
A kind of chemical illumination immunity analysis instrument, including sampling system, centrifugation systems, sample reagent disc system, incubation cleaning system, Systems for optical inspection and control system.Above-mentioned chemical illumination immunity analysis instrument, for whole blood sample, internal centrifugation systems first can carry out centrifugal treating to sample, then pattern detection is carried out again, by that will be centrifuged and detection is integrated, so that the magnetic particle formula chemiluminescence of high measurement accuracy, can be applied to the application scenarios of quick diagnosis.Meanwhile the design of miniaturization, also avoid large automatic analysis instrument structure is complicated, is at high cost, high failure rate the drawbacks of.Above-mentioned chemical illumination immunity analysis instrument has accurate detection, quick diagnosis, inexpensive competitive advantage.
Description
Technical field
The present invention relates to medical equipment technological field more particularly to a kind of chemical illumination immunity analysis instruments.
Background technique
Magnetic particle formula chemiluminescence immune assay has that high sensitivity, high specificity, the range of linearity be wide, high degree of automation
Etc. advantageous features, it has also become the main means of clinical diagnosis.But it is limited by the limitation of reagent, chemical illuminating reagent mostly uses
Serum or plasma sample are tested, the influence to avoid red blood cell to testing result.Therefore, sample before testing, needs people
Work carries out centrifugal treating to sample, and complicated for operation, intermediate link increases.The man-handling of materials of sample is centrifuged, and not only brings operation
On uncertainty, while substantially prolonging from sample collection to the time for obtaining testing result.For a small amount of individual samples
Quick diagnosis scene is then unable to satisfy requirement, so that up to the present, this high-precision detection of magnetic particle formula chemiluminescence
Means can't really be applied to quick diagnosis field.
Summary of the invention
In consideration of it, it is necessary to provide a kind of chemical illumination immunity analysis instruments for being able to carry out quick diagnosis.
A kind of chemical illumination immunity analysis instrument, including sampling system, centrifugation systems, sample reagent disc system, incubation cleaning
System, Systems for optical inspection and control system；
The sampling system includes sampling needle driving assembly and the sampling needle that is fixedly connected with the sampling needle driving assembly,
The sampling system is used for the imbibition and drain of sample and reagent；
The centrifugation systems include centrifugal pan component and the first driving mechanism, offer centrifugation on the centrifugal pan component
Hole, first driving mechanism is for driving the centrifugal pan component to rotate, and the centrifugation systems are for being centrifuged sample
Processing；
The sample reagent disc system includes sample reagent disk and the second driving mechanism, and the sample reagent disk is equipped with sample
This placement position and reagent place position, and second driving mechanism is for driving the sample reagent disc spins；
The incubation cleaning system includes being incubated for heating component, reaction cup holder component and cleaning assembly, the incubation heating
Component includes groove plate and the heater set on groove plate bottom, the reaction cup holder component include reaction cup holder and
Third driving mechanism, the reaction cup are set up in the groove of the groove plate, offer reaction cup on the reaction cup holder
Hole, for the third driving mechanism for driving the reaction cup holder to move along the groove, the cleaning assembly includes injection needle
Unit, aspirating needle unit, the 4th driving mechanism and the 5th driving mechanism, the injection needle unit and the aspirating needle unit are all provided with
In the top of the groove, the position that the bottom portion of groove of the groove plate corresponds to aspirating needle unit is equipped with magnet, institute
The 4th driving mechanism is stated for driving the injection needle of the injection needle unit to move up and down, the 5th driving mechanism is for driving
The aspirating needle of the aspirating needle unit moves up and down；
The Systems for optical inspection includes fluorescence detector, and the fluorescence detector is set on the groove plate, described
Fluorescence detector is used to detect the signal in the reaction cup on reaction cup holder；
The sampling system, the centrifugation systems, the sample reagent disc system, the incubation cleaning system, the light
Detection system is learned to be electrically connected with the control system respectively.
In one embodiment, the centrifugal pan component includes centrifugal pan and the bracket on the centrifugal pan, described
Centrifugal hole is opened on the bracket.
In one embodiment, the position that centrifugal hole is offered on the bracket is equipped with adapter.
In one embodiment, sampling needle driving assembly is rotary-type sampling needle driving assembly or linear motion-type sampling needle
Driving assembly.
In one embodiment, the sample places position and the reagent places position along the circumference side of the sample reagent disk
It is arranged to interval.
In one embodiment, the sample reagent disc system further includes refrigerator, the refrigerator and sample examination
Agent disk is fixedly connected.
In one embodiment, the groove plate is linear type groove plate, circular groove plate or curvilinear shaped recesses
Plate.
It in one embodiment, further include cleaning cell system, the cleaning cell system is used for the cleaning of the sampling needle.
It in one embodiment, further include bar code scanner, the bar code scanner is electrically connected with the control system, institute
The outside that bar code scanner is located at sample reagent disc system is stated, the bar code scanner is for reading sample bar code information and reagent
Bar code information.
It in one embodiment, further include touch screen, the touch screen is electrically connected with the control system.
Above-mentioned chemical illumination immunity analysis instrument, for whole blood sample, internal centrifugation systems can first to sample carry out from
Heart processing, then carries out pattern detection again, by that will be centrifuged and detection is integrated, so that the magnetic particle formula of high measurement accuracy
It learns and shines, can be applied to the application scenarios of quick diagnosis.Meanwhile the design of miniaturization, also avoid large automatic analysis
The drawbacks of apparatus structure is complicated, at high cost, high failure rate.Above-mentioned chemical illumination immunity analysis instrument has accurate detection, quickly examines
Disconnected, inexpensive competitive advantage.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the chemical illumination immunity analysis instrument of an embodiment.
Specific embodiment
In order to be more clear the objectives, technical solutions, and advantages of the present invention, with reference to the accompanying drawings and embodiments, to this hair
It is bright to be further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and do not have to
It is of the invention in limiting.
As shown in Figure 1, the chemical illumination immunity analysis instrument 100 of an embodiment, including sampling system, centrifugation systems, sample
This reagent disc system is incubated for cleaning system, Systems for optical inspection and control system 70.Sampling system, centrifugation systems, sample reagent
Disc system, incubation cleaning system, Systems for optical inspection are electrically connected with control system 70 respectively.
Sampling system 10 includes sampling needle driving assembly 12 and sampling needle (not shown).Sampling needle driving assembly 12 and sampling
Needle is fixedly connected, and sampling system is used for the imbibition and drain of sample and reagent.
In the embodiment shown in figure 1, sampling needle driving assembly 12 can be rotary-type sampling needle driving assembly.Rotation
Type sampling needle driving assembly includes rotary motion structure and up and down motion structure.Specifically, sampling needle driving assembly include shaft,
With the rotating bar and sampling needle motor-driven mechanism of shaft rotation connection.Rotating bar one end and sampling needle far from shaft are fixed
Connection.Sampling needle motor-driven mechanism include drive the driving mechanism that rotates around the axis of rotating bar and driving sampling needle relative to
The driving mechanism that shaft moves up and down.It is appreciated that sampling needle driving assembly 12 or the driving of linear motion-type sampling needle
Component.Linear motion-type sampling needle driving assembly includes structure of linear motion and up and down motion structure.Sampling needle driving assembly energy
Sampling needle is enough set to have the function of that sampling needle may be implemented in sample on the motion profile of sampling needle in horizontal rotation and up and down motion
This reagent disc system, centrifugation systems and be incubated for cleaning system between liquid assimilating and be discharged into movement, and realization sampling needle exist
Clean the cleaning of cell system.
Centrifugation systems include centrifugal pan component and the first driving mechanism (not shown).First driving mechanism can be driving electricity
Machine.For first driving mechanism for driving centrifugal pan component to rotate, centrifugal pan component has height under the driving of the first driving mechanism
Speed rotation and positioning function.Centrifugation systems carry out centrifugal treating to sample.Centrifugal hole 22 is offered on centrifugal pan component.Centrifugal hole
22 quantity is one, two or more.It is appreciated that the quantity of centrifugal hole 22 can be configured according to actual needs.
In each centrifugal hole, open centrifuge tube can be placed, for containing the whole blood sample of sampling needle addition.In the first driving mechanism
Drive under, centrifuge tube rotate together at high speed movement with centrifugal pan component, generates centrifugal effect, reaches whole blood sample centrifugation
Purpose.
Specifically, centrifugal pan component includes centrifugal pan 24 and the bracket 26 on centrifugal pan 24.Centrifugal hole 22 is opened in
On bracket 26.The position that centrifugal hole 22 is offered on bracket 26 is equipped with adapter (not shown).The quantity of adapter be one, two
It is a or multiple.Can be placed on each adapter a centrifuge tube or it is other can be with liquid filling container.Under stationary state, fit
Vertical line direction is presented in orchestration, and when rotary motion, adapter and the liquid container being placed in adapter together, are being centrifuged
Under power effect, one fixed angle of wing drop when rotary motion stops, and can automatically restore to initial perpendicular direction.
Sample reagent disc system 30 includes sample reagent disk 32 and the second driving mechanism (not shown), on sample reagent disk 32
Position 34 is placed equipped with sample and reagent places position 36.Sample place position 34 and reagent place position 36 be respectively used to place sample tube and
Kit.Second driving mechanism is for driving sample reagent disk 32 to rotate.Second driving mechanism can be driving motor.Sample examination
The periphery of agent disk 32 is equipped with sample reagent disk outer pot 38.
In embodiment as shown in Figure 1, sample places position 34 and reagent places position 36 along the circle of sample reagent disk 32
The setting of circumferential direction interval.It is appreciated that in other embodiments, sample places position 34 and reagent is placed position 36 and be may not be
It is spaced apart, but subregional continuously distributed or other distribution modes.
Sample reagent disc system further includes refrigerator (not shown).Refrigerator is fixedly connected with sample reagent disk 32.Refrigeration
Device is that sample reagent disk 32 provides cooling capacity.Sample reagent disc system can be realized simultaneously the storage of sample and reagent, refrigerates and turns
Transport function.
Being incubated for cleaning system includes being incubated for heating component, reaction cup holder component and cleaning assembly.Being incubated for cleaning system can be with
It is arranged among sample reagent disc system and centrifugation systems, the outer of sample reagent disc system and centrifugation systems can also be arranged in
Side.It is incubated for cleaning system and is responsible for sample reagent incubation, multistage cleaning separation and substrate function of injecting.
Being incubated for heating component includes groove plate 42 and the heater (not shown) set on 42 bottom of groove plate.Heater
It is heated to entire groove plate 42.In the embodiment shown in figure 1, groove plate 42 is linear type groove plate.
It is appreciated that groove plate may be circular groove plate, arc groove plate or other curvilinear shaped recesses plates.Concave-board
Groove on block 42 is set on the motion profile of sampling needle.
Reacting cup holder component includes reaction cup holder 44 and third driving mechanism 45.It reacts cup holder 44 and is set to groove plate 42
In groove, reacts and offer one on cup holder 44, two or more reaction cup aperture 46.Reaction cup aperture 46 can be used for placing instead
Cup is answered, and to the sample and reagent progress incubation with heat in reaction cup.
Third driving mechanism can be driving motor.Third driving mechanism 45 is moved for drive response cup holder 44 along groove
It is dynamic.Under the action of third driving mechanism, reaction cup holder 44 can move back and forth in the groove of groove plate 42, and stop
Arbitrary position is only arrived, realizes transfer operation of the reaction cup between different location.
Cleaning assembly includes injection needle unit 47, aspirating needle unit 48, the 4th driving mechanism (not shown) and the 5th driving
Mechanism (not shown).Aspirating needle unit 48 includes one, two or more aspirating needles.Injection needle unit 47 includes one, two
A or multiple injection needles.Injection needle unit 47 and aspirating needle unit 48 are set to the top of groove.Aspirating needle and injection needle can
It, can also continuous several aspirating needle arrangements then continuous several injection needle arrangements to be intervally arranged.The bottom of the groove of groove plate
The position that portion corresponds to aspirating needle unit 48 is equipped with magnet 49.The quantity of magnet 49 and the quantity of aspirating needle are identical.Or magnet
49 length is identical as the arrangement length of aspirating needle unit washing lotion needle.The quantity of magnet 49 is not limited to particular number, need to only expire
The position that sufficient aspirating needle corresponds to groove plate 42 has magnet.4th driving mechanism and the 5th driving mechanism can be
Driving motor.4th driving mechanism is for driving the injection needle of injection needle unit 47 to move up and down.Injection needle can be in 4 wheel driven
It moves up and down under the action of motivation structure, moves downward to extend into reaction cup and carry out fluid injection, travel upward and out reaction cup.5th
Driving mechanism is for driving the aspirating needle of aspirating needle unit 48 to move up and down.Aspirating needle can be under the action of five driving mechanisms
It moves up and down, moves downward to extend into reaction cup and carry out imbibition, travel upward and out reaction cup.Injection needle unit 47 can be used
In injection cleaning solution or substrate.
It is same to be arranged when groove plate is circular groove plate, arc groove plate or other curvilinear shaped recesses plates
There are injection needle unit 47, aspirating needle unit 48 and magnet 49.
Above-mentioned incubation cleaning system 40 is led to using straight-line groove plate body structure by the way that reaction cup holder 44 is arranged in groove
Crossing third driving mechanism 45 can be moved back and forth with drive response cup holder 44, and be stopped at an arbitrary position, and structure is simple, significantly
Reduce the complexity and size of chemical illumination immunity analysis instrument 100.
Systems for optical inspection includes fluorescence detector 50, and fluorescence detector 50 is set on groove plate 42, fluorescence detector
50 for detecting the signal in the reaction cup on reaction cup holder 44.
In the embodiment shown in figure 1, above-mentioned chemical illumination immunity analysis instrument 100 further includes bar code scanner 60, item
Code scanner 60 is electrically connected with control system 70.Bar code scanner 60 is located at the outside of sample reagent disc system, bar code scanner
60 for reading sample bar code information and reagent bar code information.Bar code scanner 60 can scan for one-dimensional or two-dimensional bar code
Instrument.
In the embodiment shown in figure 1, above-mentioned chemical illumination immunity analysis instrument 100 further includes cleaning cell system, cleaning
Cell system is used for the cleaning of sampling needle.Cleaning cell system includes service sink 80.In the embodiment shown in figure 1, service sink 80
By straight-line groove plate 42.
Above-mentioned chemical illumination immunity analysis instrument 100 further includes the liquid channel system for connecting entire instrument.
Above-mentioned chemical illumination immunity analysis instrument 100 further includes touch screen (not shown), and touch screen is electrically connected with control system 70
It connects, the control of machine system operation can be carried out by touch screen.Above-mentioned all members are respectively mounted on the rack, touch screen
It can be set in front end of rack.Above-mentioned chemical illumination immunity analysis instrument 100 can also external computer controlled.
The workflow of above-mentioned chemical illumination immunity analysis instrument 100 is as follows:
A, by sampling needle motor-driven mechanism, control sampling needle moves to the sample position in sample reagent disk 32, leads to
The second driving mechanism of sample reagent disc system is crossed, the sample controlled on sample reagent disk 32 rotates to sample position, sampling needle
Sample is drawn in decline, is then risen rotation, is moved to the sample-adding position on the bracket 26 of centrifugal pan component, sample is drained into centrifugation
Guan Zhong, then control sampling needle moves to cleaning position and is cleaned, while being centrifuged disc system and carrying out high speed rotation centrifugation.
B, by sampling needle motor-driven mechanism, sampling needle is controlled from the centrifuge tube on the bracket 26 of centrifugal pan component,
Sample is drawn, is drained into the reaction cup for being incubated for and being reacted in cleaning system on cup holder 44.For not needing the sample being centrifuged,
The centrifugation step of step a is needed not move through, sampling needle directly from the sample bit in sample reagent disk 32, is drawn sample, is discharged into
It is incubated in the reaction cup reacted in cleaning system in cup holder 44, then control sampling needle moves to cleaning position and cleaned.
C, by sampling needle motor-driven mechanism, control sampling needle moves to the suction reagent sites in sample reagent disk 32,
Sample reagent disk 32 is driven to rotate by the second driving mechanism, control reagent rotates to sample position, and examination is drawn in sampling needle decline
Then agent rises rotary motion to the drain location for being incubated for cleaning system, reagent is drained into the reaction cup on reaction cup holder 44
In, then control sampling needle moves to cleaning position and is cleaned.
D, be incubated for cleaning system in third driving mechanism 45, control reaction cup holder 44 in the groove of groove plate 42 into
Row moves back and forth, and carries out incubation heating.
F, after the completion of incubation, the control reaction cup holder 44 of third driving mechanism 45 being incubated in cleaning system moves to cleaning solution
Position is injected, is injected in the reaction cup on cleaning solution to reaction cup holder 44 by injection needle unit 47, then control reaction cup holder 44
The binding domain equipped with magnet 49 is moved to, after carrying out absorption a period of time to the magnetic particle in liquid in reaction cup, control is inhaled
Liquid needle unit 48 draws the liquid in reaction cup, achievees the purpose that cleaning.It is repeated multiple times, it completes to be cleaned multiple times.
G, after the completion of cleaning, the third driving mechanism 45 being incubated in cleaning system, control reaction cup holder 44 moves to substrate
Position is injected, injection substrate carries out incubation heating into the reaction cup reacted on cup holder 44.
H, it is incubated for after the completion of heating, the third driving mechanism 45 being incubated in cleaning system, control reaction cup holder 44 moves to
Light position is surveyed, the reaction cup reacted in cup holder 44 using 50 on tos on to of fluorescence detector is carried out signal-obtaining, obtains measurement result, is completed
Entire measurement procedure.
Above-mentioned chemiluminescence analysis system 100 may be implemented the directly upper machine of serum, blood plasma, urine, whole blood equal samples and survey
Examination, machine is to testing result is obtained from sample, and whole process all realize by automation.
Sample centrifugal treating is realized in the above-mentioned automation of chemiluminescence analysis system 100, reduces manual steps, greatly
Shorten detection time, carry out pattern detection with chemiluminescent method, has quick and high measurement accuracy dual characteristics；And
Structure is simple, low in cost, and product reliability is high, and high degree of automation, user's operation is simple, and precision is high, and detection speed is fast, can
With the chemical illuminating reagent of the various differential responses modes of compatibility test.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should be regarded as
Protection scope of the present invention.
Claims (10)
1. a kind of chemical illumination immunity analysis instrument, which is characterized in that including sampling system, centrifugation systems, sample reagent disc system,
It is incubated for cleaning system, Systems for optical inspection and control system；
The sampling system includes sampling needle driving assembly and the sampling needle that is fixedly connected with the sampling needle driving assembly, described
Sampling system is used for the imbibition and drain of sample and reagent；
The centrifugation systems include centrifugal pan component and the first driving mechanism, offer centrifugal hole on the centrifugal pan component, institute
The first driving mechanism is stated for driving the centrifugal pan component to rotate, the centrifugation systems are used to carry out centrifugal treating to sample；
The sample reagent disc system includes sample reagent disk and the second driving mechanism, and the sample reagent disk is put equipped with sample
Set and reagent place position, and second driving mechanism is for driving the sample reagent disc spins；
The incubation cleaning system includes being incubated for heating component, reaction cup holder component and cleaning assembly, the incubation heating component
Heater including groove plate and set on groove plate bottom, the reaction cup holder component include reaction cup holder and third
Driving mechanism, the reaction cup are set up in the groove of the groove plate, offer reaction cup aperture, institute on the reaction cup holder
Third driving mechanism is stated for driving the reaction cup holder to move along the groove, the cleaning assembly include injection needle unit,
Aspirating needle unit, the 4th driving mechanism and the 5th driving mechanism, the injection needle unit and the aspirating needle unit are set to institute
State the top of groove, the position that the bottom portion of groove of the groove plate corresponds to aspirating needle unit is equipped with magnet, and described the
For four driving mechanisms for driving the injection needle of the injection needle unit to move up and down, the 5th driving mechanism is described for driving
The aspirating needle of aspirating needle unit moves up and down；
The Systems for optical inspection includes fluorescence detector, and the fluorescence detector is set on the groove plate, the optics
Detector is used to detect the signal in the reaction cup on reaction cup holder；
The sampling system, the centrifugation systems, the sample reagent disc system, the incubation cleaning system, optics inspection
Examining system is electrically connected with the control system respectively.
2. chemical illumination immunity analysis instrument as described in claim 1, which is characterized in that the centrifugal pan component includes centrifugal pan
With the bracket being set on the centrifugal pan, the centrifugal hole is opened on the bracket.
3. chemical illumination immunity analysis instrument as claimed in claim 2, which is characterized in that offer centrifugal hole on the bracket
Position is equipped with adapter.
4. chemical illumination immunity analysis instrument as described in claim 1, which is characterized in that sampling needle driving assembly is rotary-type adopts
Sample needle driving assembly or linear motion-type sampling needle driving assembly.
5. chemical illumination immunity analysis instrument as described in claim 1, which is characterized in that the sample places position and the reagent
Position is placed to be arranged along the circumferencial direction interval of the sample reagent disk.
6. chemical illumination immunity analysis instrument as described in claim 1, which is characterized in that the sample reagent disc system further includes
Refrigerator, the refrigerator are fixedly connected with the sample reagent disk.
7. chemical illumination immunity analysis instrument as described in claim 1, which is characterized in that the groove plate is linear type groove
Plate, circular groove plate or curvilinear shaped recesses plate.
8. chemical illumination immunity analysis instrument as described in claim 1, which is characterized in that it further include cleaning cell system, it is described clear
Wash pool system is used for the cleaning of the sampling needle.
9. chemical illumination immunity analysis instrument as described in claim 1, which is characterized in that it further include bar code scanner, the item
Code scanner is electrically connected with the control system, and the bar code scanner is located at the outside of sample reagent disc system, the bar code
Scanner is for reading sample bar code information and reagent bar code information.
10. chemical illumination immunity analysis instrument as described in claim 1, which is characterized in that it further include touch screen, the touch screen
It is electrically connected with the control system.
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| CN201810183818.XA CN110231472A (en) | 2018-03-06 | 2018-03-06 | A kind of chemical illumination immunity analysis instrument |
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| CN201810183818.XA CN110231472A (en) | 2018-03-06 | 2018-03-06 | A kind of chemical illumination immunity analysis instrument |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110672832A (en) * | 2019-11-14 | 2020-01-10 | 重庆中元汇吉生物技术有限公司 | Chemiluminescence immunoassay appearance |
| CN111983249A (en) * | 2020-08-28 | 2020-11-24 | 沈阳瑞好生物科技有限公司 | Chemiluminescence immunodetection analyzer for in-situ luminescence determination and detection method |
| CN114236129A (en) * | 2021-12-20 | 2022-03-25 | 江苏集萃纳米应用技术研究所有限公司 | In-vitro immunodiagnosis reagent background luminescence processing system |
| CN117517640A (en) * | 2023-10-30 | 2024-02-06 | 苏州思迈德生物科技有限公司 | Sample analyzer, control system and control method of sample analyzer |
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| JPH06182257A (en) * | 1992-12-21 | 1994-07-05 | Nittec Co Ltd | Centrifuge |
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