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CN1191826C - 药物制剂 - Google Patents

药物制剂 Download PDF

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CN1191826C
CN1191826C CNB981063640A CN98106364A CN1191826C CN 1191826 C CN1191826 C CN 1191826C CN B981063640 A CNB981063640 A CN B981063640A CN 98106364 A CN98106364 A CN 98106364A CN 1191826 C CN1191826 C CN 1191826C
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CN1195524A (zh
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A·苏珀萨克所
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Abstract

本发明涉及一种新的用于药物局部施用的药物配方，尤其是非甾族的抗炎药(NSAID’s)，包括：(a)一种治疗有效量的药物；(b)磷酸钠缓冲剂；和任选的(c)一种醇溶剂。

Description

药物制剂
本发明涉及一种新的用于药物的局部施用的药物制剂，尤其是非甾族的抗炎药(NSAID’s)。
鉴于与口服制剂相关的药物负作用，NSAID’s日益通过局部的途径给药。对于成功的局部NSAID药物的先决条件是药充分地透过皮肤进入更深层组织如脂膜、筋膜、腱、韧带和肌，来治疗软组织结构的发炎变性的和外伤后的改变。水醇制剂，例如，乙醇/水和1，2-丙二醇/乙醇/水是通常使用的NSAID’s局部施用的制剂。根据本发明，已发现通过加入磷酸钠缓冲剂到这种制剂中可显著地改善NSAID的渗透。
因此，本发明是关于药物局部施用的制剂，尤其是非甾族的抗炎药(NSAID’s)，其制剂包括：
(a)一种治疗有效量的药物；
(b)磷酸钠缓冲剂；和任选的，
(c)一种醇溶剂。
根据本发明的制剂可以任何常规的施用形式给出。这种施用形式的例子是溶液、泡沫、霜剂、软膏、洗剂和凝胶。
根据本发明，制剂中所含的药物可以是任何通常局部施用的药物。在本发明中所用的最感兴趣的药是NSAID’s如萘普生、布洛芬、消炎痛、双氯灭酸、炎痛喜康或氟灭酸酯和其药物可接收的盐。对本发明来说，一种优选的NSAID是萘普生。可使用通常用于NSAID’s的药物制剂中的任何盐。这种盐的例子是碱金属盐如钠和钾盐，和取代的铵盐如与烷基胺和羟烷基胺的盐，例如二乙胺和三乙醇胺。磷酸钠缓冲剂合适的摩尔浓度范围在从约10到300mM，优选约100至约200mM。缓冲溶液的pH值优选在5和7.5之间，更优选6.0到7.5。最优选pH6.0。醇溶剂可以是任何通常用于局部制剂中的这样的溶剂。优选的醇溶剂是乙醇、异丙醇、1，2-丙二醇和其混合物。醇溶剂的另一例子是甘油。优选的醇溶剂是乙醇和1，2-丙二醇3∶1份重量比的混合物。
如果需要一种凝胶制剂，可以使用任何通常用于药物凝胶制剂中的凝胶成形剂。凝胶成形剂的例子是纤维素衍生物如甲基纤维素、羟乙基纤维素、羧甲基纤维素、乙烯基聚合物如聚乙烯醇，聚乙烯吡咯烷酮；和聚丙烯衍生物如聚羧乙烯。根据本发明另外的可用于组合物中的胶凝剂是果胶类、树胶类、如阿拉伯树胶和黄蓍胶、藻酸盐类、角叉酸盐类、琼脂和明胶。优选的用于本发明的胶凝剂是羟丙基甲基纤维素(HPMC)。此外，本发明的凝胶制剂还可含通常用于这种制剂中的辅剂如防腐剂、抗氧化剂、稳定剂、着色剂和香料。
在本发明的制剂中存在的活性成分的量通常与在相应的常规制剂中的相同。如果药物，例如活性成分，是一种NSAID，其量的变化是，例如，每100g制成的制剂中从约0.1到约10g的NSAID，优选0.5-2.5g，最优选每100g制成制剂约1g。磷酸钠缓冲剂的量的变化可从每100g制成的制剂中从约30到约90-99g，优选约30到约70g的100-200mM的溶液。适宜的醇溶剂的量是每100g制成制剂中从约5到约70g。在本发明的一个优选的方面，醇溶剂包含约20到约40g的乙醇和约5到约30g的1，2-丙二醇。在凝胶制剂中，足以获得对在皮肤上施用具有足够的粘度的凝胶制剂的胶凝剂的量取决于所用的特定胶凝剂或介质和所期望的制成的凝胶制剂的粘度，并可通过药物制剂专家根据个别要求确定。
根据本发明的制剂可用常规方式制备。例如，药物，如一种NSAID溶于水缓冲液，和任选地醇共溶剂。然后所得溶液可通过加入胶凝剂，例如羟乙基纤维素或羟丙基甲基纤维素胶凝。
下面的实施例阐述本发明：
实施例1
从下面的组分制得一种凝胶；
组分                                       〔克〕
萘普生钠                                   1.1
乙醇                                       30.0
1，2-丙二醇                                10.0
pH 6.0的200mM的磷酸钠缓冲水溶液             50.0
羟乙基纤维素                                1.6
水，加至足量                                100.0
                    实施例2
从下面的组分制得一种凝胶；
组分                                        〔克〕
萘普生钠                                    1.1
乙醇                                        30.0
1，2-丙二醇                                 10.0
pH 6.0的100mM的磷酸钠缓冲水溶液             50.0
羟丙甲基纤维素                              2.5
水，加至足量                                100.0
                    实施例3
从下面的组分制得一种凝胶：
组分                                        〔克〕
萘普生(游离酸)                              1.0
三乙醇胺                                    0.65
乙醇                                        30.0
1，2-丙二醇                                 10.0
pH 6.0的200mM的磷酸钠缓冲水溶液             50.0
羟乙基纤维素                                1.6
水，加至足量                                100.0
                    实施例4
从下面的组分制得一种凝胶：
组分                                        〔克〕
萘普生钠                                    2.74
乙醇                                        30.0
1，2-丙二醇                              10.0
pH 6.0的200mM的磷酸钠缓冲水溶液          50.0
羟乙基纤维素                             1.6
水，加至足量                             100.0
                     实施例5
从下面的组分制得一种凝胶：
组分                                     〔克〕
萘普生钠                                 5.5
乙醇                                     30.0
1，2-丙二醇                              10.0
pH 6.0的200mM的磷酸钠缓冲水溶液          50.0
羟乙基纤维素                             1.6
水，加至足量                             100.0
                     实施例6
从下面的组分制得一种凝胶：
组分                                     〔克〕
萘普生钠                                 1.1
乙醇                                     30.0
1，2-丙二醇                              10.0
pH 6.0的100mM的磷酸钠缓冲水溶液          50.0
羟乙基纤维素                             1.6
水，加至足量                             100.0
                     实施例7
从下面的组分制得一种凝胶：
组分                                     〔克〕
萘普生钠                                 1.1
pH 7.25的100mM的磷酸钠缓冲水溶液        50.0
羟乙基纤维素                            1.6
水，加至足量                            100.0
                     实施例8
皮肤渗透研究：
测定了萘普生从根据本发明的制剂(实施例1)、从一相应的非缓冲的制剂(制剂B)和从一先有技术制剂(Naprosyn GELTM，制剂A)的皮肤渗透。制备的制剂A和B具有如下给出的组合物：
制剂                       A〔克〕    B〔克〕
萘普生(游离酸)             10.0       -
萘普生钠                   -          1.1
三乙醇胺                   13.0       -
乙醇                       30.0       30.0
1，2-丙二醇                -          10.0
羟乙基纤维素               -          1.6
卡波沫940(Carbomer 940)    2          -
焦亚硫酸钠                 0.1        -
玫瑰香料                   0.03       -
水加至足量                 100.0      100.0
将人尸体的腹部皮肤的皮肤样品切成皮板(0.38mm)并在-80℃冷冻。实验的当天，皮肤样品解冻并置于扩散截面1cm2和接受室体积5ml的Franz型扩散小室中。安装有磁搅拌棒的接收室充满1mM、PH7.4的磷酸盐缓冲盐水。然后扩散小室转移至恒温在32℃的加热箱中。随着3-4小时的平衡期后，用微量移液管将5mg/cm2的试验制剂施用到表皮表面上。在非封闭的条件下于32℃孵化45小时后，取出接收溶液并用HPLC测定萘普生的浓度。结果示于图1中。
图1表示萘普生从Naproxyn GEL(A)、1，2-丙二醇/乙醇水(B)和1，2-丙二醇/乙醇/磷酸钠缓冲剂凝胶(实施例1)透过人尸体皮肤的体外透皮实验结果。每个柱代表用得自七个不同供体的皮肤进行的七个实验的几何平均值。***＝P＜0.005，NS＝无显著性；通过“学生”配成对的t-检验与Naprosyn GEL相比较。

Claims (7)

1.一种用于局部施用的胶凝制剂，每100g该制剂含有：
(a)0.1g-10g的非甾体抗炎药；
(b)30g-90g的10-300mM的磷酸钠缓冲剂，该缓冲剂的pH为5-7.5；
(c)5g-70g的醇溶剂；
(d)至少一种胶凝剂，该胶凝剂的量足以获得一种具有足够的粘度以适用于皮肤上的胶凝制剂。
2.根据权利要求1的胶凝制剂，每100g该制剂含有：
(e)0.1g-10g的非甾体抗炎药；
(f)30g-70g的100-200mM的磷酸钠缓冲剂，该缓冲剂的pH为6-7.5；
(c1)20g-40g乙醇和/或异丙醇；
(c2)5g-30g丙二醇；和
(d)至少一种胶凝剂，该胶凝剂的量足以获得一种具有足够的粘度以适用于皮肤上的胶凝制剂。
3.根据权利要求1的胶凝制剂，其中所述磷酸钠缓冲剂的pH为6。
4.根据前述权利要求1-3中任何一项的胶凝制剂，其中所述胶凝剂为羟丙基甲基纤维素。
5.根据前述权利要求1-3中任何一项的胶凝制剂，其中所述非甾体抗炎药为萘普生钠。
6.根据权利要求1-3中任何一项的胶凝制剂，其中所述非甾体抗炎药的含量为1％。
7.权利要求5的胶凝制剂，其中萘普生钠的含量为1％。
CNB981063640A 1997-04-10 1998-04-09 药物制剂 Expired - Fee Related CN1191826C (zh)

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US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
US20090088443A1 (en) * 2002-02-15 2009-04-02 Julius Remenar Novel crystalline forms of conazoles and methods of making and using the same
WO2004060347A2 (en) * 2002-09-03 2004-07-22 Transform Pharmaceuticals, Inc. Pharmaceutical propylene glycol solvate compositions
US7927613B2 (en) * 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US7790905B2 (en) * 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
CA2477923C (en) * 2002-03-01 2021-02-23 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
US20030191187A1 (en) * 2002-04-01 2003-10-09 Lee Fang Yu Injectable pharmaceutical composition containing a non-steroidal anti-inflammatory drug and method for preparing the same
US20070059356A1 (en) * 2002-05-31 2007-03-15 Almarsson Oern Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
JP2006500377A (ja) * 2002-06-21 2006-01-05 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 改善された溶解性を有する医薬組成物
AU2003267231A1 (en) * 2002-09-20 2004-04-08 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
US7166641B2 (en) * 2002-10-02 2007-01-23 Yung Shin Pharmaceutical Industrial Co., Ltd. Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same
WO2004047752A2 (en) * 2002-11-26 2004-06-10 Transform Pharmaceuticals, Inc. Pharmaceutical formulations of celcoxib
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
US7132452B2 (en) * 2003-03-10 2006-11-07 Fang-Yu Lee Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection
US20050042182A1 (en) * 2003-08-13 2005-02-24 Moshe Arkin Topical compositions of urea
US20050037040A1 (en) * 2003-08-13 2005-02-17 Moshe Arkin Topical compositions of urea and ammonium lactate
US20050036953A1 (en) * 2003-08-13 2005-02-17 Moshe Arkin Topical compositions of ammonium lactate
US20050020552A1 (en) * 2003-07-16 2005-01-27 Chaim Aschkenasy Pharmaceutical composition and method for transdermal drug delivery
US20050025833A1 (en) * 2003-07-16 2005-02-03 Chaim Aschkenasy Pharmaceutical composition and method for transdermal drug delivery
US20050042268A1 (en) * 2003-07-16 2005-02-24 Chaim Aschkenasy Pharmaceutical composition and method for transdermal drug delivery
ES2622403T3 (es) * 2004-11-05 2017-07-06 Lead Chemical Co. Ltd. Preparación no acuosa para absorción percutánea que contiene analgésico antiinflamatorio no esteroideo
US20070287741A1 (en) * 2006-06-13 2007-12-13 Uri Herzberg Compositions and methods for preventing or reducing postoperative ileus and gastric stasis in mammals
US20080220068A1 (en) * 2006-07-31 2008-09-11 Laboratories Besins International Treatment and prevention of excessive scarring
JP5869219B2 (ja) * 2007-08-16 2016-02-24 レメドー バイオメッド リミテッド 治療および美容適用のためのエリスロポイエチンおよびフィブロネクチン組成物
PL214538B1 (pl) 2009-05-28 2013-08-30 P P F Hasco Lek Spolka Akcyjna Kompozycja liposomowa zawierajaca naproksen i sposób wytwarzania kompozycji liposomowej zawierajacej naproksen
AU2011225811B2 (en) * 2010-03-12 2014-04-03 Council Of Scientific & Industrial Research A process for the preparation of inorganic hydrogels with alkali halides
US9012402B1 (en) 2014-06-11 2015-04-21 James Blanchard Gel for topical delivery of NSAIDs to provide relief of musculoskeletal pain and methods for its preparation
US10821075B1 (en) 2017-07-12 2020-11-03 James Blanchard Compositions for topical application of a medicaments onto a mammalian body surface
KR20190101140A (ko) * 2018-02-22 2019-08-30 동아제약 주식회사 비스테로이드성 소염진통 활성성분을 함유하는 필름 형성 약제학적 조성물
MX2021009038A (es) * 2019-01-29 2021-08-16 Bayer Healthcare Llc Composiciones topicas de naproxeno en gel.

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5829706A (ja) * 1981-08-14 1983-02-22 Toko Yakuhin Kogyo Kk 消炎鎮痛外用剤
JPS6253933A (ja) * 1985-09-02 1987-03-09 Nitto Electric Ind Co Ltd 外皮投与用組成物
JPH085800B2 (ja) * 1986-12-19 1996-01-24 エーザイ株式会社 塩化リゾチ−ム及びグリチルリチン酸ジカリウム含有水溶液製剤
US4720353A (en) * 1987-04-14 1988-01-19 Richardson-Vicks Inc. Stable pharmaceutical w/o emulsion composition
US5183829A (en) * 1991-09-27 1993-02-02 Applied Analytical Industries, Inc. Oral liquid compositions of non-steroidal anti-inflammatory drugs
BR9306816A (pt) * 1992-07-28 1998-12-08 Procter & Gamble Composição farmaceutica para uso tópico contendo um polímero catiônico reticulado e um eter alcoxilado
DK0694310T3 (da) * 1993-04-16 2000-06-05 Wakamoto Pharma Co Ltd Reversibelt, termisk gelatinerende, vandbaseret, medicinsk præparat
EP0711147A1 (en) * 1993-07-28 1996-05-15 Insite Vision Incorporated Suspensions for delivery of medicament
JPH07223942A (ja) * 1994-02-03 1995-08-22 Ildong Pharm Co Ltd プロピオン酸系非ステロイド性薬物を有効成分として含有する新規消炎鎮痛外用ゲル製剤
CN1106259A (zh) * 1994-02-05 1995-08-09 日东制药株式会社 含有作为有效成分的丙酸类非类固醇性药物的新颖消炎镇痛外用凝胶制剂
US5733900A (en) * 1994-04-21 1998-03-31 Hisamitsu Pharmaceutical Co., Inc. Percutaneous administration base composition and percutaneous administration medicinal composition comprising said base composition and medicine
IT1275955B1 (it) * 1995-03-22 1997-10-24 Dompe Spa Formulazioni farmaceutiche in forma di gel tissotropico
JPH0967272A (ja) * 1995-08-31 1997-03-11 Advanced Sukin Res Kenkyusho:Kk 局所適用組成物
GB9626513D0 (en) * 1996-12-20 1997-02-05 Bioglan Ireland R & D Ltd A pharmaceutical composition
JP2001518879A (ja) * 1997-03-31 2001-10-16 ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド 薬剤化合物の向上した浸透性のための溶媒システム

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US6420394B1 (en) 2002-07-16
AR012376A1 (es) 2000-10-18
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ATE243043T1 (de) 2003-07-15
CA2232855C (en) 2007-10-09
BR9803300A (pt) 2000-01-11
PT872247E (pt) 2003-10-31
EP0872247B1 (en) 2003-06-18
CN1195524A (zh) 1998-10-14
ZA982872B (en) 1998-10-12
DK0872247T3 (da) 2003-09-29
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ES2201361T3 (es) 2004-03-16
CA2232855A1 (en) 1998-10-10

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