CN118122209A - Drug granule granulating system containing glucosamine and chondroitin sulfate sodium - Google Patents
Drug granule granulating system containing glucosamine and chondroitin sulfate sodium Download PDFInfo
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- CN118122209A CN118122209A CN202410267325.XA CN202410267325A CN118122209A CN 118122209 A CN118122209 A CN 118122209A CN 202410267325 A CN202410267325 A CN 202410267325A CN 118122209 A CN118122209 A CN 118122209A
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- bin
- collecting
- materials
- stirring
- distributing
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- 239000003814 drug Substances 0.000 title claims abstract description 27
- 239000008187 granular material Substances 0.000 title claims abstract description 16
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 title claims abstract description 12
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 title claims abstract description 12
- 229940079593 drug Drugs 0.000 title claims abstract description 9
- 229940006423 chondroitin sulfate sodium Drugs 0.000 title claims description 9
- 229960002849 glucosamine sulfate Drugs 0.000 title claims description 6
- 239000000463 material Substances 0.000 claims abstract description 149
- 238000003756 stirring Methods 0.000 claims abstract description 53
- 238000012216 screening Methods 0.000 claims abstract description 42
- 239000002245 particle Substances 0.000 claims abstract description 27
- 238000001035 drying Methods 0.000 claims abstract description 11
- 238000005469 granulation Methods 0.000 claims abstract description 10
- 230000003179 granulation Effects 0.000 claims abstract description 10
- 238000009835 boiling Methods 0.000 claims abstract description 8
- 229960002442 glucosamine Drugs 0.000 claims abstract description 6
- 230000003139 buffering effect Effects 0.000 claims abstract description 4
- 239000012257 stirred material Substances 0.000 claims abstract description 4
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 claims abstract description 3
- 239000013590 bulk material Substances 0.000 claims description 39
- 239000000872 buffer Substances 0.000 claims description 23
- 238000007789 sealing Methods 0.000 claims description 15
- 238000007599 discharging Methods 0.000 claims description 7
- 239000007769 metal material Substances 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 230000000903 blocking effect Effects 0.000 claims description 3
- 239000004744 fabric Substances 0.000 claims description 3
- 238000009434 installation Methods 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 238000001179 sorption measurement Methods 0.000 claims description 2
- 230000007423 decrease Effects 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 11
- 238000006243 chemical reaction Methods 0.000 description 10
- 239000000843 powder Substances 0.000 description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 229920002567 Chondroitin Polymers 0.000 description 2
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- -1 glucosamine series salt Chemical class 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 150000001728 carbonyl compounds Chemical class 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005243 fluidization Methods 0.000 description 1
- 150000002301 glucosamine derivatives Chemical class 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 229960003299 ketamine Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/16—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by suspending the powder material in a gas, e.g. in fluidised beds or as a falling curtain
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/836—Mixing plants; Combinations of mixers combining mixing with other treatments
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/836—Mixing plants; Combinations of mixers combining mixing with other treatments
- B01F33/8364—Mixing plants; Combinations of mixers combining mixing with other treatments with drying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of granulation, and particularly relates to a drug granule granulating system containing glucosamine and sodium chondroitin sulfate, which comprises a boiling drying granulator and a mixing stirrer, wherein the boiling drying granulator comprises a frame, a top bin, a middle bin, a bottom bin, a collecting device and a screening device, the screening device is arranged in the bottom bin and is detachable, the mixing stirrer comprises a stirring device, an adjusting device, a material guiding device, a material distributing device and a bulk cargo device, the stirring device is matched with the screening device and is used for stirring materials, the adjusting device is used for stopping and blanking the stirred materials, the material guiding device is used for guiding the materials to the material distributing device, the material distributing device is used for dispersing the materials, and the bulk cargo device is used for buffering and shaking the materials; compared with the prior art, the invention can mix and stir two material particles while improving the granulating efficiency, combines the mixing and stirring procedures into one, reduces the equipment cost, and improves the mixing and stirring efficiency of the materials to a certain extent.
Description
Technical Field
The invention relates to the technical field of granulation, in particular to a drug granule granulating system containing glucosamine and chondroitin sulfate sodium.
Background
The maillard reaction is also called a non-enzymatic browning reaction, which is a non-enzymatic browning widely existing in the food industry, and is a reaction between carbonyl compounds (reducing saccharides) and amino compounds (amino acids and proteins), and a complex process is carried out to finally generate brown or even black macromolecular melanoidins or melanoidins, so that the maillard reaction is also called a ketamine reaction.
The glucosamine series salt and the chondroitin sulfate sodium are classical formulas of the bone joint health-care food, but the two raw materials are mixed together, so that the amino group on the glucosamine is easy to react with carbonyl group on the chondroitin sulfate to generate Maillard reaction, and the Maillard reaction can be delayed to generate brown substances with time under the condition of temperature, moisture and PH change, thereby influencing the sense of the product.
Generally, the drug granules are subjected to granulation by a granulator, granulation by a screening mechanism, mixing by a stirring device, tabletting by a tablet press and the like to finally obtain granules.
In the prior art, a boiling granulator is mainly composed of a bottom bin, a main bin and a top bin, wherein material powder particles are in an annular fluidization state in the main bin, preheated and mixed by purified heating air, and an adhesive solution is atomized and sprayed into the main bin, so that a plurality of particles are polymerized into granules containing adhesive, and the materials are continuously dried by the heating air, so that moisture in the granules is evaporated, the adhesive is solidified, and the process is repeatedly performed to form ideal uniform microporous spherical particles; in the granulating process of the granulator, as granulating, material powder is mixed with a solution so as to be extremely easy to adhere to a top bin, so that the cleaning of the top bin is troublesome in the later stage, and the size of processed particles is not easy to screen in the granulating process, so that in the later stage of processing, more small particles which do not meet the specification exist, and the processing progress of granulating causes dragging;
In the processing process of the medicine granules formed by glucosamine series salt and chondroitin sulfate sodium, in order to reduce Maillard reaction, the two materials are respectively required to be granulated and mixed, and then the two materials are stirred; for the stirring and mixing steps in the processing process of the medicine granules, corresponding stirring devices and mixing devices are needed for processing, and materials are required to be carried and moved in the connection process of the mixing and stirring steps, so that the expenditure of equipment purchase is increased, and meanwhile, the granulating efficiency is greatly reduced.
Disclosure of Invention
Aiming at the defects existing in the prior art, the invention aims to provide a drug granule granulating system for solving the technical problems.
In order to achieve the above purpose, the present invention provides the following technical solutions:
a granulating system for granule containing glucosamine and sodium chondroitin sulfate comprises a boiling drying granulator and a mixing stirrer,
The fluidized drying granulator comprises a frame, a top bin, a middle bin, a bottom bin, a collecting device and a screening device, wherein the top bin is fixed on the frame, the middle bin is hinged with the frame and rotates in the horizontal direction, the bottom bin is detachably connected with the frame, the top bin, the middle bin and the bottom bin are sequentially and hermetically butted from top to bottom, the collecting device is used for blocking and collecting materials, the collecting device is arranged in the top bin and can be detached, the screening device is used for screening and collecting material particles, the screening device is arranged in the bottom bin and can be detached,
The mixing stirrer comprises a stirring device, an adjusting device, a material guiding device, a material distributing device and a bulk material device, wherein the stirring device is matched with the screening device and used for stirring materials, the adjusting device is used for stopping and discharging the stirred materials, the material guiding device is used for guiding the materials to the material distributing device, the material distributing device is used for dispersing the materials, and the bulk material device is used for buffering and shaking the materials.
Further, the collecting device comprises a mounting ring, a collecting cover, a disturbance ball and a collecting screen plate, wherein the collecting cover and the collecting screen plate are sequentially fixed on the mounting ring from top to bottom, the cross section of the collecting cover is arc-shaped and is composed of filter cloth, the collecting screen plate is bowl-shaped, the collecting screen plate and the collecting cover form a collecting space, the disturbance ball is arranged in the collecting space, and the disturbance ball is composed of hollow elastic balls.
Further, the screening device comprises a net barrel and a mounting ring, the mounting ring is fixed at the top of the net barrel, a barrel body and a barrel bottom of the net barrel are provided with a plurality of screening holes, the barrel bottom is formed by an integrally formed annular net piece and a middle net piece, the cross section of the annular net piece is U-shaped, the middle net piece is in an inverted bowl shape, and the barrel body is in an inverted truncated cone shape; the installation ring is connected with the bottom end of the middle bin in a sealing way, the net barrel stretches into the bottom bin, an air inlet is formed in the bottom bin, and the air inlet is arranged below the screening device.
Further, agitating unit includes agitator tank, the unloading pipe, sealed lid, a motor, the agitator tank bottom is placed in to the unloading pipe and intercommunication agitator tank and guider, one side is equipped with the auxiliary shaft in the agitator tank, the epaxial cover of auxiliary is equipped with spring and stop collar, the both ends of spring are contradicted with the inner wall of agitator tank and the one end of stop collar respectively, the other end and the middle part net piece cooperation of stop collar, the opposite side is equipped with the main shaft in the agitator tank, the one end and the output of first motor are connected, be fixed with the locating head on the other end of main shaft, be equipped with embedded groove and constant head tank on the collar, sealed lid includes interconnect's lid and locating piece, the lid can stretch into the embedded groove, the locating piece is pegged graft with the constant head tank, open on the lid have with the draw-in groove of locating head joint, the lid is last to have inlayed magnet, the collar comprises the metal material of being connected with magnet absorption.
Further, the material guiding device is composed of a material receiving box and a material guiding hopper, the material guiding hopper is arranged in the material receiving box, the material discharging pipe is communicated with the material receiving box and corresponds to the material guiding hopper, the material guiding hopper is provided with a material guiding channel, and the diameter of the material guiding channel is gradually reduced in the direction from top to bottom.
Further, adjusting device includes second motor and regulating disk, and the second motor is fixed in the top that connects the workbin, and the output and the regulating disk fixed connection of second motor have offered on the regulating disk with unloading pipe complex via hole.
Further, the feed divider includes branch workbin, dead lever and branch charging tray, and the cross-section that connects the workbin is circular and connect the diameter of workbin to reduce from top to bottom by the centre gradually, connects workbin and branch workbin intercommunication, and dead lever and branch charging tray are arranged in the branch workbin and the dead lever is connected and is divided the charging tray, and the branch charging tray corresponds with the guide hopper, and the cross-section of branch charging tray is arcuation and downwarping.
Further, the bulk cargo device comprises a blanking pipe, a bulk cargo mechanism and a buffer mechanism, wherein the blanking pipe is communicated with the material distribution box, the bulk cargo mechanism comprises a cylinder, a connecting rod and a plurality of bulk cargo disturbance parts, the bulk cargo disturbance parts are arranged in the blanking pipe and are composed of bulk cargo plates and connecting rods which are connected with each other, the middle part of each bulk cargo plate is provided with a bulk cargo part which bulges upwards, the blanking pipe is provided with a strip-shaped hole, the connecting rod penetrates through the strip-shaped hole and is hinged with the connecting rod, the cylinder is connected with the connecting rod, and the cylinder can drive the bulk cargo parts to swing up and down; the buffer mechanism comprises buffer pieces corresponding to the bulk material disturbance pieces one by one, and the buffer pieces comprise elastic rods connected with the blanking pipe and buffer plates fixedly connected with the elastic rods, and the bulk material disturbance pieces and the buffer pieces are distributed in a staggered mode.
Further, the material distributing device further comprises a fan, an air pipe and an air nozzle, wherein the air pipe is connected with the fan and the air nozzle, the air nozzle is fixed in the material distributing box, and the air nozzle blows air from bottom to top.
Further, the bulk cargo plate and the buffer plate are both composed of silica gel.
By adopting the technical scheme, the invention has the beneficial effects that:
1. When the glucosamine and the chondroitin are granulated together, the two materials are contacted fully, and because a wetting agent is added and finally the mixture is dried at high temperature, the Maillard reaction is promoted (the reaction is easy to be accelerated at high temperature and high moisture), and the glucosamine salt and the chondroitin sulfate sodium powder are respectively granulated by a boiling drying granulator and a mixing stirrer and then are mixed, so that the two are prevented from being simultaneously in a high-temperature environment;
2. the primary screening of the particle size can be realized through the screening device of the fluidized drying granulator, so that the screening and collecting efficiency of the particles is greatly improved; the collecting device can separate and collect powder during granulation, so that the powder is not easy to adhere in the top bin, and the collecting device is convenient to detach and clean, so that the time for cleaning the top bin is greatly saved;
3. The mixing stirrer can mix and stir two kinds of material particles, combines the mixing and stirring processes into one, reduces the equipment cost, and has certain promotion to the mixing and stirring efficiency of materials.
Drawings
FIG. 1 is a schematic diagram of a fluidized bed dryer granulator.
Fig. 2 is a schematic structural view of the collecting device.
Fig. 3 is a schematic structural view of the screening apparatus.
Fig. 4 is a schematic structural view of the mixer.
Fig. 5 is a schematic structural view of the screening device mated with the agitator tank.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the description of the present invention, it should be understood that the terms "upper," "lower," "front," "rear," "left," "right," "top," "bottom," "inner," "outer," and the like indicate or are based on the orientation or positional relationship shown in the drawings, merely to facilitate description of the present invention and to simplify the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention.
The processing steps of the medicine granule containing glucosamine and chondroitin sulfate sodium are as follows:
Granulating: granulating sodium chondroitin and glucosamine materials in a boiling drying granulator respectively, and obtaining a dried material A and a dried material B respectively;
Mixing: respectively adding magnesium stearate into the dried materials A and B, and uniformly mixing by a mixing stirrer;
tabletting: tabletting the mixture to obtain the medicine granule tablet.
Regarding the ebullated dry granulator:
The fluidized drying granulator comprises a frame 1, a top bin 2, a middle bin 3, a bottom bin 4, a collecting device 5 and a screening device 6, wherein the top bin 2 is fixed on the frame 1, the middle bin 3 is hinged with the frame 1 and rotates in the horizontal direction, the bottom bin 4 is detachably connected with the frame 1, the top bin 2, the middle bin 3 and the bottom bin 4 are sequentially sealed and butted from top to bottom, the collecting device 5 is used for blocking and collecting materials, the collecting device 5 is arranged in the top bin 2 and can be detached, the screening device 6 is used for screening and collecting material particles, the screening device 6 is arranged in the bottom bin 4 and can be detached, an air inlet is formed in the bottom bin 4, and the air inlet is arranged below the screening device 6;
During operation of the granulator, air enters the bottom bin 44 from the air inlet and blows powdery materials into the middle bin 33, and at the moment, the peristaltic pump pumps liquid auxiliary materials (formed by mixing additives, wall materials and purified water) into the middle bin 33 in a mist form and mixes the auxiliary materials with the materials to form particles, and the temperature is maintained to a proper degree, so that stable drying of formed drug particles is ensured.
As shown in fig. 2, the collecting device 5 includes a mounting ring 51, a collecting cover 52, a disturbance ball 53 and a collecting screen 54, the collecting screen 54 may be made of metal material, the collecting cover 52 and the collecting screen 54 are sequentially fixed on the mounting ring 51 from top to bottom, the cross section of the collecting cover 52 is arc-shaped and is made of filter cloth, the collecting screen 54 is bowl-shaped, the collecting screen 54 and the collecting cover 52 form a collecting space, the disturbance ball 53 is placed in the collecting space, and the disturbance ball 53 is made of hollow elastic balls;
Along with the granulating process, a part of materials enter the top bin 2 and are intercepted by the collecting device 5; when the material enters the collecting space through the rigid collecting screen plate 54, the material is intercepted by the collecting cover 52, and the collecting cover 52 bulges upwards and shakes under the action of wind force, so that the material powder is not easy to adhere to the collecting cover; under the action of wind force, the elastic disturbance ball 53 moves randomly in the collecting space, and the disturbance ball 53 impacts the collecting screen plate 54 and the collecting cover 52, so that the material powder adhered to the two is shaken off, and the material is not easy to remain in the top bin 2; the bowl-shaped collecting screen plate 54 is lower in the middle and higher in the two sides, namely, the collecting screen plate is concave downwards, so that materials falling on the collecting screen plate are easy to collect in the middle, the materials in the collecting screen plate are convenient to collect, the contact area between the collecting screen plate 54 and the materials is larger, the collecting screen plate 54 is not easy to block, and the granulating work is affected;
The collecting device 5 is fixed in the top bin 2 through the mounting ring 51, and the collecting device 5 can be taken down through the mounting ring 51 which is detached, so that the collecting device 5 is cleaned, materials left on the collecting device 5 are prevented from being browned and then fall into processed materials again, and then the quality of medicine particles is influenced.
As shown in fig. 2, the screening device 6 comprises a screen drum 61 and a mounting ring 62, the mounting ring 62 is fixed at the top of the screen drum 61, a drum body and a drum bottom of the screen drum 61 are provided with a plurality of screening holes, the drum bottom is formed by an integrally formed annular net sheet 601 and a middle net sheet 602, the cross section of the annular net sheet 601 is U-shaped, the middle net sheet 602 is in a reverse-buckled bowl shape, and the drum body is in a reverse truncated cone shape; the mounting ring 62 is connected with the bottom end of the middle bin 3 in a sealing way, and the net drum 61 extends into the bottom bin 4;
In the granulating process, powder at the bottom in the bottom bin 4 enters the middle bin 3 after passing through a plurality of screening holes on the net drum 61 under the action of wind force, and is mixed with auxiliary materials to be granulated and falls on the net drum 61, so that the larger medicine particles are filtered and retained on the net drum 61, and the smaller medicine particles fall back into the bottom bin 4 through screening meshes; over time, until no material exists in the bottom bin 4, the completion of granulation is realized;
the middle high side part of the bottom of the net drum 61 is low, so that the medicine particles falling on the net drum slide to two sides, thereby freeing the middle and not affecting the granulation; when the screening device 6 is installed on the bottom bin 4, the net drum 61 stretches into the bottom bin 4, and the installation ring 62 is arranged at the top end of the bottom bin 4.
Regarding the mixing stirrer:
The mixer comprises a stirring device 7, an adjusting device 81, a material guiding device 82, a material distributing device 83 and a bulk material device 84; two kinds of medicine particles are respectively stirred through the cooperation of the stirring device 7 and the screening device 6, then the two kinds of materials after stirring are fed, the materials after stirring are cut off and fed through the adjusting device 81, the material guiding device 82 is used for guiding the falling materials to the material distributing device 83, the material distributing device 83 is used for fully dispersing and mixing the two kinds of materials, and the bulk material device 84 is used for buffering the materials and further shaking, dispersing and mixing the materials.
The stirring device 7 can be provided with two or more stirring devices 7, the stirring device 7 comprises a stirring box 71, a blanking pipe 72, a sealing cover 73 and a first motor 74, the blanking pipe 72 is arranged at the bottom of the stirring box 71 and is communicated with the stirring box 71 and a material guiding device 82, an auxiliary shaft 75 is arranged on one side in the stirring box 71, a spring 76 and a limiting sleeve 77 are sleeved on the auxiliary shaft 75, two ends of the spring 76 are respectively abutted against the inner wall of the stirring box 71 and one end of the limiting sleeve 77, the other end of the limiting sleeve 77 is matched with a middle net 602, a main shaft 78 is arranged on the other side in the stirring box 71, one end of the main shaft 78 is connected with the output end of the first motor 74, a positioning head 79 is fixed on the other end of the main shaft 78, an embedded groove 6201 and a positioning groove 6202 are formed in the mounting ring 62, the sealing cover 73 comprises a cover 731 and a positioning block 732 which are mutually connected, the cover 731 can extend into the embedded groove 6201, the positioning block is spliced with the positioning groove 6202, a clamping groove 733 is clamped with the positioning head 731, a magnet 734 is embedded on the cover, the mounting ring 62 is formed by a metal material which is in adsorption connection with the sealing cover 73, and the sealing cover 73 is connected with the magnetic ring in a stable connection mode, and the stable connection can be realized through the magnetic connection;
when the materials are stirred, the screening device 6 after the granulation is taken out from the bottom bin 4, a proper amount of auxiliary materials (magnesium stearate) are added into the screening device 6, and then the screening device 6 is arranged in the stirring box 71, namely, the sealing cover 73 is connected with the mounting ring 62 firstly, so that the sealing of the net drum 61 is realized; the sealing cover 73 can be additionally provided with stirring rods or stirring sheets which extend into the net drum 61; then, the middle net piece 602 is aligned with the limiting sleeve 77, the end part of the limiting sleeve 77 extends into the concave part of the middle net piece 602, then the net barrel 61 is pushed towards the limiting sleeve 77, and the spring 76 is compressed until the clamping groove 733 corresponds to the positioning head 79; finally, the spring 76 is reset, and the positioning head 79 is clamped with the clamping groove 733, so that the screening device 6 is installed; thus, the screening devices 6 of the two types of materials are respectively arranged in the stirring boxes 71 of the two stirring devices 7;
Then the first motor 74 is started, and the first motor 74 drives the two screen devices to rotate through the main shaft 78, so that the stirring of materials in the two screen devices is realized; because the diameter of the bottom of the net drum 61 is far smaller than that of the top, when the net drum 61 is placed on the side, the medicine particles move towards the direction of the sealing cover 73 under the action of gravity, so that the medicine particles can be disturbed more efficiently along with the rotation of the net drum 61; the stirring efficiency and the stirring effect of the stirring rod can be further improved by matching with the stirring rod and other parts, so that the auxiliary materials can be more uniformly adhered to the two types of medicine particles; in order to prevent the auxiliary materials from leaking from the net drum 61, a sealing sleeve matched with the shape of the net drum 61 can be sleeved on the net drum 61, and the sealing sleeve can be made of flexible materials.
The material guiding device 82 is composed of a material receiving box 821 and a material guiding hopper 822, the material guiding hopper 822 is arranged in the material receiving box 821, the discharging pipe 72 is communicated with the material receiving box 821 and corresponds to the material guiding hopper 822, the material guiding hopper 822 is provided with a material guiding channel 8201, and the diameter of the material guiding channel 8201 is gradually reduced in the direction from top to bottom; the adjusting device 81 comprises a second motor 811 and an adjusting disc 812, the second motor 811 is fixed at the top of the material receiving box 821, the output end of the second motor 811 is fixedly connected with the adjusting disc 812, and a through hole 8101 matched with the blanking pipe is formed in the adjusting disc 812;
When the materials are stirred, the regulating disk 812 seals the through hole 8101, so that the materials in the stirring box are prevented from leaking; after the material stirring is completed, the screening device 6 is removed from the stirring box, and the stirred material is poured into the corresponding stirring box; then the second motor 811 starts and drives the adjusting disk 812 to rotate until the through hole 8101 is communicated with the blanking pipe, and then the material falls into the guide hopper 822 after passing through the blanking pipe and the through hole 8101; the second motor 811 is adjusted to control the opening and closing time of the blanking pipe, so that the blanking amount of the material is controlled; the guide hopper 822 is thick and thin, so that two materials are primarily mixed through the guide channel 8201 and discharged onto the material distributing disc.
The material distributing device 83 comprises a material distributing box 831, a fixed rod 832, a material distributing disc 833, a fan 834, an air pipe 835 and an air nozzle 836, wherein the section of the material distributing box 831 is circular, the diameter of the material distributing box 831 is gradually reduced from the middle to the upper side and the lower side, the material distributing box 821 is communicated with the material distributing box 831, the fixed rod 832 and the material distributing disc 833 are arranged in the material distributing box 831, the fixed rod 832 is connected with the material distributing disc 833 and the material distributing box 831, the material distributing disc 833 corresponds to the guide hopper, and the section of the material distributing disc 833 is arc-shaped and is bent downwards; the air duct 835 connects the blower 834 and the air nozzle 836, the air nozzle 836 is fixed in the distributing box 831, and the air nozzle 836 blows air from bottom to top.
The materials fall on the distributing disc 833 under the guide of the guide hopper, and the two materials fall on the top of the circular cap shape and then fall to the side of the distributing disc 833, so that the medicine particles are dispersed under the action of the distributing disc 833, and the two kinds of medicine particles are convenient to comprehensively contact and mix; the medicine particles fall on the inner wall of the material separating box 831 with a spherical space after passing through the material separating disc 833, and the two kinds of medicine particles are mixed again in the material separating box 831; at the same time, the fan 834 is started and sends air into the air nozzle 836 through the air pipe 835, and the air disturbs the medicine particles in the distribution box 831, so that the two materials are further mixed, and auxiliary material dust in the distribution box 831 can be blown and adhered to the materials.
The bulk material device 84 comprises a bulk material pipe 841, a bulk material mechanism and a buffer mechanism, wherein the bulk material pipe 841 is communicated with a material distributing box 831, the bulk material mechanism comprises an air cylinder 842, a connecting rod 843 and a plurality of bulk material disturbance members 844, the bulk material disturbance members 844 are arranged in the bulk material pipe 841, each bulk material disturbance member 844 is composed of a bulk material plate 801 and a connecting rod 802 which are mutually connected, the middle part of the bulk material plate 801 is provided with a bulk material part 803 which is upwards bulged, the bulk material pipe 841 is provided with a strip-shaped hole 8401, the connecting rod 802 penetrates through the strip-shaped hole 8401 and is hinged with the connecting rod 843, the air cylinder 842 is connected with the connecting rod 843, and the air cylinder 842 can drive the bulk material members to swing up and down; the buffer mechanism comprises buffer members 845 which are in one-to-one correspondence with a plurality of bulk material disturbance members 844, the buffer members 845 comprise elastic rods 805 connected with the bulk material pipes 841 and buffer plates 806 fixedly connected with the elastic rods 805, the bulk material disturbance members 844 and the buffer members 845 are arranged in a staggered manner, and the bulk material plates 801 and the buffer plates 806 are all made of silica gel;
The materials fall into the dispersing pipe 841 after being separated by the material separating box 831, and when the materials pass through the dispersing pipe 841, the air cylinder 842 drives the dispersing plate 801 to swing up and down through the connecting rod 843, so that the medicine particles falling on the dispersing plate 801 are lifted up and dispersed, and further mixing of the two materials is realized; the upward raised bulk material parts 803 can enlarge the contact area with the materials, and can further realize the scattering of the materials; the buffer plate 806 on the other side buffers and guides the falling material, so that the material is not easy to damage due to impact.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the invention, but one skilled in the art can make common changes and substitutions within the scope of the technical solution of the present invention.
Claims (10)
1. A drug granule granulating system containing glucosamine and chondroitin sulfate sodium comprises a boiling drying granulator and a mixing stirrer, and is characterized in that,
The boiling drying granulator comprises a frame, a top bin, a middle bin, a bottom bin, a collecting device and a screening device, wherein the top bin is fixed on the frame, the middle bin is hinged with the frame and rotates in the horizontal direction, the bottom bin is detachably connected with the frame, the top bin, the middle bin and the bottom bin are sequentially and hermetically butted from top to bottom, the collecting device is used for blocking and collecting materials, the collecting device is arranged in the top bin and can be detached, the screening device is used for screening and collecting material particles, the screening device is arranged in the bottom bin and can be detached,
The mixing stirrer comprises a stirring device, an adjusting device, a material guiding device, a material distributing device and a bulk material device, wherein the stirring device is matched with the screening device and used for stirring materials, the adjusting device is used for stopping and discharging the stirred materials, the material guiding device is used for guiding the materials to the material distributing device, the material distributing device is used for dispersing the materials, and the bulk material device is used for buffering and shaking the materials.
2. The system of claim 1, wherein the collecting device comprises a mounting ring, a collecting cover, a disturbing ball and a collecting screen plate, the collecting cover and the collecting screen plate are sequentially fixed on the mounting ring from top to bottom, the cross section of the collecting cover is arc-shaped and is composed of filter cloth, the collecting screen plate is bowl-shaped, the collecting screen plate and the collecting cover form a collecting space, the disturbing ball is arranged in the collecting space, and the disturbing ball is composed of hollow elastic balls.
3. The drug granule granulating system containing glucosamine and chondroitin sulfate sodium according to claim 1 or 2, wherein the screening device comprises a net barrel and a mounting ring, the mounting ring is fixed at the top of the net barrel, a barrel body and a barrel bottom of the net barrel are provided with a plurality of screening holes, the barrel bottom is composed of an integrally formed annular net sheet and a middle net sheet, the cross section of the annular net sheet is U-shaped, the middle net sheet is in a reverse-buckled bowl shape, the barrel body is in a reverse-truncated cone shape,
The installation ring is in sealing connection with the bottom end of the middle bin, the net barrel extends into the bottom bin, an air inlet is formed in the bottom bin, and the air inlet is arranged below the screening device.
4. A granulating system comprising glucosamine and sodium chondroitin sulfate according to claim 3, wherein the stirring apparatus comprises a stirring tank, a discharging pipe, a sealing cover and a first motor, wherein the discharging pipe is arranged at the bottom of the stirring tank and is communicated with the stirring tank and the material guiding device,
An auxiliary shaft is arranged at one side in the stirring box, a spring and a limiting sleeve are sleeved on the auxiliary shaft, two ends of the spring respectively abut against the inner wall of the stirring box and one end of the limiting sleeve, the other end of the limiting sleeve is matched with the middle net sheet,
A main shaft is arranged at the other side in the stirring box, one end of the main shaft is connected with the output end of the first motor, a positioning head is fixed at the other end of the main shaft,
The mounting ring is provided with an embedded groove and a positioning groove, the sealing cover comprises a cover body and a positioning block which are connected with each other, the cover body can extend into the embedded groove, the positioning block is inserted into the positioning groove, the cover body is provided with a clamping groove which is clamped with the positioning head, the cover body is embedded with a magnet, and the mounting ring is formed by a metal material which is in adsorption connection with the magnet for writing.
5. The granulating system of claim 4, wherein the guide device comprises a receiving box and a guide hopper, the guide hopper is arranged in the receiving box, the discharging pipe is communicated with the receiving box and corresponds to the guide hopper, the guide hopper is provided with a guide channel, and the diameter of the guide channel gradually decreases from top to bottom.
6. The granulation system of claim 5, wherein the adjusting device comprises a second motor and an adjusting disc, the second motor is fixed at the top of the material receiving box, the output end of the second motor is fixedly connected with the adjusting disc, and the adjusting disc is provided with a through hole matched with the blanking pipe.
7. The granulating system of claim 6, wherein the distributing device comprises a distributing box, a fixing rod and a distributing tray, the cross section of the distributing box is circular, the diameter of the distributing box is gradually reduced from the middle to the upper side and the lower side, the distributing box is communicated with the distributing box, the fixing rod and the distributing tray are arranged in the distributing box, the fixing rod is connected with the distributing tray and the distributing box, the distributing tray corresponds to the guide hopper, and the cross section of the distributing tray is arc-shaped and bent downwards.
8. The granulating system of claim 7, wherein the bulk material device comprises a blanking pipe, a bulk material mechanism and a buffer mechanism, the blanking pipe is communicated with the distributing box,
The bulk material mechanism comprises a cylinder, a connecting rod and a plurality of bulk material disturbance parts, wherein the bulk material disturbance parts are arranged in a blanking pipe, each bulk material disturbance part consists of a bulk material plate and a connecting rod which are connected with each other, the middle part of the bulk material plate is provided with a bulk material part which bulges upwards, the blanking pipe is provided with a strip-shaped hole, the connecting rod penetrates through the strip-shaped hole and is hinged with the connecting rod, the cylinder is connected with the connecting rod, and the cylinder can drive the bulk material parts to swing up and down;
The buffer mechanism comprises buffer pieces corresponding to the bulk material disturbance pieces one by one, the buffer pieces comprise elastic rods connected with the blanking pipe and buffer plates fixedly connected with the elastic rods,
The bulk material disturbance pieces and the buffer pieces are arranged in a staggered mode.
9. The granulating system of claim 6, wherein the distributing device further comprises a blower, an air pipe and an air nozzle, the air pipe is connected with the blower and the air nozzle, the air nozzle is fixed in the distributing box, and the air nozzle blows air from bottom to top.
10. The granulation system of claim 8, wherein the bulk and buffer plates are each comprised of silica gel.
Applications Claiming Priority (2)
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| CN2023103511629 | 2023-03-29 | ||
| CN202310351162.9A CN116236450A (en) | 2023-03-29 | 2023-03-29 | Method for delaying browning in granulating process of glucosamine and sodium chondroitin sulfate |
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| CN118122209A true CN118122209A (en) | 2024-06-04 |
| CN118122209B CN118122209B (en) | 2024-09-20 |
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| CN202310351162.9A Pending CN116236450A (en) | 2023-03-29 | 2023-03-29 | Method for delaying browning in granulating process of glucosamine and sodium chondroitin sulfate |
| CN202410267325.XA Active CN118122209B (en) | 2023-03-29 | 2024-03-08 | Drug granule granulating system containing glucosamine and chondroitin sulfate sodium |
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| CN202310351162.9A Pending CN116236450A (en) | 2023-03-29 | 2023-03-29 | Method for delaying browning in granulating process of glucosamine and sodium chondroitin sulfate |
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Also Published As
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| CN116236450A (en) | 2023-06-09 |
| CN118122209B (en) | 2024-09-20 |
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