CN115884989A - 靶向PD-L1和TGFβ的双功能融合蛋白及其制备方法与应用 - Google Patents
靶向PD-L1和TGFβ的双功能融合蛋白及其制备方法与应用 Download PDFInfo
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Abstract
本发明提供了一种靶向结合程序性细胞死亡配体‑1(PD‑L1)和转化生长因子β(TGFβ)的双功能融合蛋白，还提供了编码本发明融合蛋白的核酸分子、用于表达本发明融合蛋白的表达载体、宿主细胞和方法，以及包含本发明融合蛋白的药用组合物。本发明还提供了靶向结合PD‑L1和TGFβ的双功能融合蛋白在治疗肿瘤疾病中的医疗用途。
Description
PCT国内申请，说明书已公开。
Claims (50)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020108967969 | 2020-08-31 | ||
| CN202010896796 | 2020-08-31 | ||
| PCT/CN2021/115231 WO2022042715A1 (zh) | 2020-08-31 | 2021-08-30 | 靶向PD-L1和TGFβ的双功能融合蛋白及其制备方法与应用 |
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| Publication Number | Publication Date |
|---|---|
| CN115884989A true CN115884989A (zh) | 2023-03-31 |
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| CN202180002930.9A Pending CN115884989A (zh) | 2020-08-31 | 2021-08-30 | 靶向PD-L1和TGFβ的双功能融合蛋白及其制备方法与应用 |
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| Country | Link |
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| CN (1) | CN115884989A (zh) |
| WO (1) | WO2022042715A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117736323A (zh) * | 2022-09-21 | 2024-03-22 | 三优生物医药(上海)有限公司 | 抗pd-l1抗体及其用途 |
| WO2024164807A1 (zh) * | 2023-02-06 | 2024-08-15 | 贝达药业股份有限公司 | 多特异性抗体及其应用 |
| CN117106082B (zh) * | 2023-09-15 | 2024-10-29 | 成都蓉生药业有限责任公司 | 一种抗TGFβ的人源化纳米抗体 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2752424C2 (ru) * | 2014-02-10 | 2021-07-28 | Мерк Патент Гмбх | Направленное ингибирование tgf бета |
| CN110050000B (zh) * | 2017-05-12 | 2022-07-26 | 苏州盛迪亚生物医药有限公司 | 含有TGF-β受体的融合蛋白及其医药用途 |
| KR20210090643A (ko) * | 2018-11-09 | 2021-07-20 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | TGF-β 수용체 융합 단백질 약학적 조성물 및 이의 용도 |
| CN115947846A (zh) * | 2019-09-12 | 2023-04-11 | 普米斯生物技术(珠海)有限公司 | 一种抗pd-l1纳米抗体及其衍生物和用途 |
| CN111848800B (zh) * | 2020-07-31 | 2023-07-04 | 三优生物医药(上海)有限公司 | Pd-l1单结构域抗体及其用途 |
| CN112745391B (zh) * | 2019-10-30 | 2022-11-22 | 三优生物医药(上海)有限公司 | Pd-l1结合分子 |
-
2021
- 2021-08-30 CN CN202180002930.9A patent/CN115884989A/zh active Pending
- 2021-08-30 WO PCT/CN2021/115231 patent/WO2022042715A1/zh active Application Filing
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| WO2022042715A1 (zh) | 2022-03-03 |
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