CN115414519B - Sanitary towel for relieving cold in uterus and preparation method thereof - Google Patents
Sanitary towel for relieving cold in uterus and preparation method thereof Download PDFInfo
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- CN115414519B CN115414519B CN202211010882.0A CN202211010882A CN115414519B CN 115414519 B CN115414519 B CN 115414519B CN 202211010882 A CN202211010882 A CN 202211010882A CN 115414519 B CN115414519 B CN 115414519B
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- 238000002360 preparation method Methods 0.000 title claims abstract description 67
- 210000004291 uterus Anatomy 0.000 title claims abstract description 25
- 239000000284 extract Substances 0.000 claims abstract description 98
- 240000002853 Nelumbo nucifera Species 0.000 claims abstract description 85
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims abstract description 85
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims abstract description 85
- 239000010410 layer Substances 0.000 claims abstract description 59
- 239000000839 emulsion Substances 0.000 claims abstract description 58
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 49
- 239000012792 core layer Substances 0.000 claims abstract description 38
- 239000000341 volatile oil Substances 0.000 claims abstract description 21
- 238000001035 drying Methods 0.000 claims abstract description 19
- 238000010521 absorption reaction Methods 0.000 claims abstract description 16
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract description 12
- 239000002344 surface layer Substances 0.000 claims abstract description 7
- 241001145025 Saussurea involucrata Species 0.000 claims description 58
- 239000000203 mixture Substances 0.000 claims description 55
- 238000003756 stirring Methods 0.000 claims description 52
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 29
- 238000000605 extraction Methods 0.000 claims description 25
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 claims description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- 239000008367 deionised water Substances 0.000 claims description 21
- 229910021641 deionized water Inorganic materials 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 20
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 18
- 150000001875 compounds Chemical class 0.000 claims description 18
- 239000003995 emulsifying agent Substances 0.000 claims description 17
- 230000008569 process Effects 0.000 claims description 17
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 16
- 101000623895 Bos taurus Mucin-15 Proteins 0.000 claims description 15
- 239000002114 nanocomposite Substances 0.000 claims description 15
- 229910001870 ammonium persulfate Inorganic materials 0.000 claims description 12
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- 239000003381 stabilizer Substances 0.000 claims description 10
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 9
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 9
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 9
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 8
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- 238000002791 soaking Methods 0.000 claims description 6
- 150000003863 ammonium salts Chemical group 0.000 claims description 5
- 238000004140 cleaning Methods 0.000 claims description 5
- TWFQJFPTTMIETC-UHFFFAOYSA-N dodecan-1-amine;hydron;chloride Chemical compound [Cl-].CCCCCCCCCCCC[NH3+] TWFQJFPTTMIETC-UHFFFAOYSA-N 0.000 claims description 5
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 5
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- 238000007873 sieving Methods 0.000 claims description 5
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 5
- GUOCOOQWZHQBJI-UHFFFAOYSA-N 4-oct-7-enoxy-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)OCCCCCCC=C GUOCOOQWZHQBJI-UHFFFAOYSA-N 0.000 claims description 4
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 4
- 244000246386 Mentha pulegium Species 0.000 claims description 4
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 4
- 229920000881 Modified starch Polymers 0.000 claims description 4
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- 235000001050 hortel pimenta Nutrition 0.000 claims description 4
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- 238000004806 packaging method and process Methods 0.000 claims description 4
- 229940080313 sodium starch Drugs 0.000 claims description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
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- 239000012785 packaging film Substances 0.000 claims description 3
- 239000000661 sodium alginate Substances 0.000 claims description 3
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- 238000004519 manufacturing process Methods 0.000 claims description 2
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- 239000008280 blood Substances 0.000 abstract description 10
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- 150000003797 alkaloid derivatives Chemical class 0.000 abstract description 2
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- 229930003935 flavonoid Natural products 0.000 abstract description 2
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- 210000003734 kidney Anatomy 0.000 abstract description 2
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- 239000002105 nanoparticle Substances 0.000 description 24
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- 229920006317 cationic polymer Polymers 0.000 description 21
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- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 12
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 12
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 12
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 12
- 235000005493 rutin Nutrition 0.000 description 12
- 229960004555 rutoside Drugs 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 11
- 241000533950 Leucojum Species 0.000 description 10
- 239000000835 fiber Substances 0.000 description 8
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- 230000002829 reductive effect Effects 0.000 description 8
- 238000004945 emulsification Methods 0.000 description 7
- 238000007720 emulsion polymerization reaction Methods 0.000 description 6
- 235000019198 oils Nutrition 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 6
- 238000006116 polymerization reaction Methods 0.000 description 6
- 208000005171 Dysmenorrhea Diseases 0.000 description 5
- 206010013935 Dysmenorrhoea Diseases 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 5
- 238000011068 loading method Methods 0.000 description 5
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- 239000000047 product Substances 0.000 description 5
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- 230000009467 reduction Effects 0.000 description 3
- 235000006679 Mentha X verticillata Nutrition 0.000 description 2
- 235000002899 Mentha suaveolens Nutrition 0.000 description 2
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
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- 239000000084 colloidal system Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
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- 239000003999 initiator Substances 0.000 description 2
- 238000003475 lamination Methods 0.000 description 2
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- 208000024891 symptom Diseases 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 229920003043 Cellulose fiber Polymers 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 101001066878 Homo sapiens Polyribonucleotide nucleotidyltransferase 1, mitochondrial Proteins 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 102100034410 Polyribonucleotide nucleotidyltransferase 1, mitochondrial Human genes 0.000 description 1
- 229920001131 Pulp (paper) Polymers 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 206010038776 Retching Diseases 0.000 description 1
- 238000004378 air conditioning Methods 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 235000020965 cold beverage Nutrition 0.000 description 1
- 235000021270 cold food Nutrition 0.000 description 1
- 230000035597 cooling sensation Effects 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
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- 230000007774 longterm Effects 0.000 description 1
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- 230000003821 menstrual periods Effects 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 230000036961 partial effect Effects 0.000 description 1
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- 230000035515 penetration Effects 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The application relates to the field of sanitary products, in particular to a sanitary towel for relieving cold in uterus and a preparation method thereof. The sanitary towel comprises a surface layer, a functional core layer, an absorption layer, a bottom film layer and a release paper layer which are sequentially arranged from the upper surface to the lower surface, wherein the functional core layer is prepared by immersing non-woven fabrics into snow lotus herb emulsion and drying. The herba Saussureae Involueratae emulsion is emulsion containing herba Saussureae Involueratae extract, such as volatile oil, alkaloid, flavonoids, phenols, saccharides, tannins, etc., and has effects of dispelling cold, supporting yang, invigorating kidney, warming uterus, dispelling blood stasis, regulating menstruation, strengthening tendons, activating collaterals, replenishing blood, invigorating qi, and relieving swelling, wherein the herba Saussureae Involueratae extract is extracted by supercritical fluid extraction. The sanitary towel containing the effective components of the snow lotus herb extract is contacted with the private parts of women, can play a role in externally assisting conditioning, and relieves discomfort caused by cold uterus during female physiology.
Description
Technical Field
The application relates to the field of sanitary products, in particular to a sanitary towel for relieving cold in uterus and a preparation method thereof.
Background
The sanitary towel is a sanitary article required by female daily life, is mainly used in female menstrual period, and is made of cotton, non-woven fabric, paper pulp or high polymer and high polymer composite paper formed by the composite materials, and has various functional types such as daily use type, night use type, pad type, added type, thickened type, light and thin type and the like.
At present, with the change of the diet structure of cold drink and cold food and the living condition of long-term living in an air-conditioning environment, more women have cold uterus symptoms, have the sense of falling and distending in the lower abdomen before the physiological period, have the phenomena of increased leucorrhea, back waist ache, distending pain in two breasts and the like, and have the reaction of regurgitation and retching in a small number; during physiological periods, abdominal pain, coldness of the lower abdomen, blood clots in menstrual color and the like can occur, and individual women can also be accompanied with dysmenorrhea.
For this, women can relieve dysmenorrhea caused by cold uterus by taking analgesic drugs, and can also regulate cold uterus by taking orally traditional Chinese medicines; however, the taking of the analgesic is only temporary pain relieving, the treatment is not to treat the root cause, the oral administration of the traditional Chinese medicine belongs to oral administration conditioning, and the decocting of the traditional Chinese medicine has long time and long taking conditioning period.
In view of the above problems, the applicant believes that the types of sanitary napkins described above are all of a structural style and color, and have little effect on external bodily regulation during female physiology.
Disclosure of Invention
In order to relieve and condition the problem of uncomfortable body symptoms caused by female cold womb, the application provides a sanitary towel for relieving cold womb and a preparation method thereof.
In a first aspect, the present application provides a sanitary towel for alleviating cold in uterus and a preparation method thereof, which adopts the following technical scheme:
a sanitary towel for relieving cold womb comprises a surface layer, a functional core layer, an absorption layer, a bottom film layer and a release paper layer which are sequentially arranged from the upper surface to the lower surface, wherein the functional core layer is prepared by immersing non-woven fabrics into snow lotus herb emulsion and drying.
The functional core layer prepared by drying contains the snow lotus herb functional components, and the functional core layer is arranged on the surface of the absorption layer, so that when a woman uses the sanitary towel, the functional core layer containing the snow lotus herb functional components can assist in playing an external auxiliary conditioning role.
The snow lotus emulsion is emulsion containing snow lotus extract, and the snow lotus extract contains effective components of snow lotus, such as volatile oil, alkaloid, flavonoids, phenols, saccharides, tannins and the like, and has the functions of removing cold, strengthening yang, tonifying kidney, warming uterus, dispelling stasis, regulating menstruation, strengthening tendons, activating collaterals, replenishing blood, replenishing qi and relieving swelling.
Preferably, the area of the functional core layer is smaller than or equal to the area of the absorption layer, and preferably the area of the functional core layer is equal to the area of the absorption layer, so that the core layer containing the saussurea involucrata extract can be contacted with the private parts of women in a larger area, thereby effectively playing an external auxiliary role in conditioning cold uterus during female physiology.
Preferably, the snow lotus herb emulsion is prepared by the following steps:
adding 2-3 parts by weight of an emulsifier into 20-30 parts by weight of ethanol water solution, uniformly stirring, then adding 2-3 parts by weight of a saussurea involucrata nano compound and 0.5-1.0 part by weight of peppermint essential oil, and uniformly dispersing by ultrasonic waves to prepare a mixture A;
adding 1-1.2 parts by weight of an emulsifier into 55-60 parts by weight of deionized water, uniformly stirring, then heating to 65-70 ℃, adding 6-8 parts by weight of a stabilizer, and uniformly stirring to obtain a mixture B;
cooling the mixture B to 55-62 ℃, adding the mixture A while homogenizing and stirring, continuing homogenizing and stirring for 20-30min after the addition, then adding 5-10 parts by weight of ethanol water solution, and homogenizing and stirring for 10-15min to obtain the snow lotus emulsion.
According to the technical scheme, the prepared snow lotus emulsion is easy to infiltrate into the non-woven fabric, the snow lotus nanocomposite components are easy to adhere to the surface of the non-woven fabric, and after the non-woven fabric is dried, a water-soluble film structure is formed on the surface of the non-woven fabric, and before the sanitary towel is not used, the snow lotus nanocomposite components are stably coated in the non-woven fabric by the water-soluble film, so that the effective components of the snow lotus extract in the snow lotus nanocomposite components are not easy to release and lose; when the sanitary towel is used in female physiological period, the water in the menstrual blood discharged by the female can dissolve the water-soluble film, so that the effective components of the snow lotus herb extract in the snow lotus herb nano-composite component are released and act on female private parts to play a role in externally assisting in conditioning cold uterus.
Wherein, because the female sanitary towel product is not used immediately after being produced and molded, the storing process is the storing process after packaging, delivery, shelf storage, purchase and the like, if the saussurea involucrata extract is directly dispersed in the solution, the saussurea involucrata extract is directly sprayed or soaked in the non-woven fabric, the effective components in the herba Saussureae Involueratae extract are easy to volatilize or release during storage, so that the content of effective components in the herba Saussureae Involueratae extract is low when the sanitary towel is used, and the external auxiliary conditioning effect is reduced. Therefore, the snow lotus herb extract is processed into the snow lotus herb emulsion through the steps, the non-woven fabric is soaked in the snow lotus herb emulsion, and after the snow lotus herb emulsion is dried, ethanol components in the snow lotus herb emulsion volatilize, so that a water-soluble film formed on the surface of the non-woven fabric by the snow lotus herb emulsion can play a coating role on the snow lotus herb extract, and effective components in the snow lotus herb extract are not easy to release in the preservation period of the sanitary towel to cause content loss, so that the external auxiliary conditioning cold womb effect of the sanitary towel is stable.
In addition, in the steps, the nanometer snow lotus compound and the mint essential oil can be uniformly emulsified and dispersed through the emulsifying agent and the ethanol water solution, and meanwhile, the stabilizing agent is uniformly emulsified and dispersed through the emulsifying agent and the ionized water, so that the prepared mixture A can be uniformly compatible and uniformly emulsified with the prepared mixture B, and the snow lotus emulsion with stable emulsification is prepared. Specifically, the essential oil component in the mixture A can be compatible with the volatile oil component of the herba Saussureae Involueratae extract in the herba Saussureae Involueratae nano-composite to form an oil phase component, the mixture B is used as a water phase component, and the mixture B is added into the mixture A for homogenizing and stirring to form an oil-in-water type herba Saussureae Involueratae emulsion, so that the herba Saussureae Involueratae emulsion can uniformly infiltrate the non-woven fabrics; the herba Menthae essential oil component has the effects of sterilizing, refreshing, relieving pain, relieving dysmenorrhea and the like, the herba Menthae essential oil component and the volatile oil component of the herba Saussureae Involueratae extract in the herba Saussureae Involueratae nano-composite are used as an oil phase to be coated in an aqueous phase, meanwhile, after the herba Saussureae Involueratae emulsion can uniformly infiltrate into non-woven fabrics, a water-soluble film is formed on the surface of the non-woven fabrics, so that the effective components in the herba Saussureae Involueratae extract are not easy to lose in the storage shelf life of the sanitary towel, and when the sanitary towel is used, the water in female menstrual blood contacts the water-soluble film and the water-soluble film is dissolved, so that the herba Menthae essential oil component and the volatile oil component in the herba Saussureae Involueratae extract are released together, and other effective components in the herba Saussureae Involueratae extract are released together to act on a human body together, and the effect of external auxiliary conditioning is achieved.
Preferably, in the preparation of the mixture A and the preparation of the mixture B, each weight part of the emulsifier is formed by mixing octadecyl polyoxyethylene ether biquaternary ammonium salt and dodecyl ammonium chloride according to the weight ratio of 2-4:1.
By adopting the above emulsifier composition, the mixture A and the mixture B can be respectively and uniformly emulsified and dispersed, so that the uniformly emulsified mixture A and the uniformly emulsified mixture B can be mutually compatible and uniform and uniformly emulsified to prepare uniform and stable snow lotus herb emulsion, so as to improve the infiltration of non-woven fabrics, improve the adhesiveness of effective components of the snow lotus herb extract in the snow lotus herb emulsion in the non-woven fabrics, and further improve the external auxiliary cold-uterus conditioning effect of the sanitary towel on human bodies.
In addition, the octadecyl polyoxyethylene ether biquaternary ammonium salt and dodecyl ammonium chloride adopted by the method have good antistatic, sterilizing, disinfecting and adsorbing effects, so that on one hand, static electricity which possibly occurs in the process of winding or unwinding the functional core layer prepared by the prepared saussurea involucrata emulsion for soaking the non-woven fabric and drying the functional core layer can be reduced; on the other hand, as the fabric of the non-woven fabric is always negatively charged, the fabric of the non-woven fabric has a repulsive action on colloidal particles in the negatively charged emulsion, so that the nanometer snow lotus compound is not easy to be adhered to the non-woven fabric, and the adopted emulsifying agent has moderate HLB value, integrates the effects of emulsification, dispersion and stabilization, can ensure that the prepared snow lotus emulsion is positively charged, has fine granularity and large specific surface area, can be stably adhered to the fibers of the non-woven fabric, and ensures that the prepared functional core layer contains more snow lotus extracts, so that the prepared sanitary towel can play the role of externally assisting in regulating cold in uterus.
Preferably, the stabilizer comprises 2-3 parts by weight of carboxymethyl cellulose, 1-2 parts by weight of sodium alginate, 0.3-1.0 parts by weight of sodium starch octenyl succinate and 1.5-2.5 parts by weight of modified starch per part by weight of the stabilizer.
The stabilizer adopted has good water solubility and certain viscosity, can be uniformly dispersed under the action of an emulsifying agent and deionized water, can be stably permeated and infiltrated into non-woven fabrics under the action of ethanol in emulsion, and volatilizes ethanol components after drying treatment, so that the emulsion can form a water-soluble film on the surface of the non-woven fabrics, the water-soluble film is contacted with water in menstrual blood during female physiological period to be dissolved, and the effective components of the snow lotus herb extract coated by the water-soluble film and the peppermint essential oil are released, thereby playing the role of externally assisting in conditioning cold uterus and dysmenorrhea.
The modified starch has good solubility at 65-70 ℃ and can be gelatinized into colloid, and the sodium starch octenyl succinate can also form a colloid structure after being dissolved in water, so that the stabilizer component can improve the viscosity of the emulsion, improve the infiltration uniformity and the adhesion uniformity of the snow lotus emulsion in non-woven fabrics, improve the content of the snow lotus extract in the non-woven fabrics, and improve the external auxiliary cold-uterus conditioning effect of the sanitary towel.
Preferably, in the preparation of the mixture A, the mass fraction of the ethanol aqueous solution is 60-70%; the ultrasonic frequency of ultrasonic dispersion is 15000-18000Hz, and the ultrasonic time is 10-12min; the mass fraction of the ethanol aqueous solution in the preparation process of the mixture A is controlled, and the ultrasonic frequency and ultrasonic time are controlled to uniformly disperse the components of the emulsifier, the saussurea involucrata nano compound and the essential oil, so that when the mixture B is added into the mixture A in the follow-up process, the two components are uniformly compatible and uniformly emulsified.
In the preparation of the mixture B, the homogenizing stirring rotating speed is 2800-4000rpm; the emulsifying agent, the stabilizing agent and the deionized water can be uniformly dispersed;
in the process of adding the mixture A into the mixture B, the homogenizing stirring rotating speed is 2800-3200rpm, and the homogenizing stirring rotating speed after the mixture A is added is 2800-4000rpm; the mixture B can be uniformly dispersed into the mixture A, and the system is uniformly emulsified to form a stable oil-in-water emulsion system so as to uniformly infiltrate into the non-woven fabric.
After the mixture A is completely added into the mixture B, the mass fraction of the ethanol aqueous solution is 60-70%, the film forming performance of the snow lotus herb emulsion can be promoted, the ethanol component is easy to volatilize under the drying condition, and the volatilization can be promoted, so that the non-woven fabric drying time after the snow lotus herb emulsion is soaked is shortened, and the condition that the active ingredient in the snow lotus herb extract is lost due to overlong drying time is reduced.
Preferably, the snow lotus herb nano-composite is prepared by the following steps:
adding 0.2-0.8 weight part of hexadecyl trimethyl ammonium bromide into 50-60 weight parts of deionized water, and uniformly stirring; then adding 10-15 parts by weight of styrene, 0.1-0.5 part by weight of acrylic acid, 0.5-2 parts by weight of butyl acrylate and 4-5 parts by weight of herba saussureae involucratae extract, and stirring for 20-30min to obtain a component I;
uniformly stirring 0.1-0.3 part by weight of hexadecyl trimethyl ammonium bromide, 0.05-0.15 part by weight of ammonium persulfate and 10-12 parts by weight of deionized water to prepare a component II;
and (3) in a protective atmosphere, dropwise adding the component II into the component I while homogenizing and stirring, after the dropwise adding is finished, carrying out heat preservation reaction, sealing and preserving heat for 90-150min at 70-80 ℃, cooling to below 40 ℃, and discharging to obtain the snow lotus nanocomposite.
By adopting the technical scheme, the cationic polymer nanoparticle loaded with the snow lotus herb extract is prepared and used as the snow lotus herb nanocomposite, wherein the cationic polymer nanoparticle formed by polymerization has positive charges, has stronger electrostatic attraction to the surface of negatively charged cellulose fiber, can be adsorbed on the surface of the fiber, can further carry the snow lotus herb extract to be adsorbed on the surface of the fiber of the non-woven fabric, and improves the adhesiveness of the active ingredients of the snow lotus herb extract.
Wherein, styrene, acrylic acid, butyl acrylate and saussurea involucrata extract are emulsified and dispersed uniformly through cetyl trimethyl ammonium bromide and deionized water to prepare the component I; simultaneously, uniformly dispersing initiator ammonium persulfate through hexadecyl trimethyl ammonium bromide and deionized water to prepare a component II; when the component II is added into the component I in a dropwise manner, the two components are uniformly compatible and emulsified, so that monomer components are subjected to emulsion polymerization to form cationic polymer nanoparticles, and the saussurea involucrata extract is mixed with the monomers, so that the saussurea involucrata extract can be stably adsorbed in the emulsion polymerization process, the prepared saussurea involucrata nanocomposite is formed by loading the saussurea involucrata extract into the cationic polymer nanoparticles, and the emulsion polymerization process can improve the loading rate of the saussurea involucrata extract on the cationic polymer nanoparticles and the adsorption adhesiveness of the cationic polymer nanoparticles loaded with the saussurea involucrata extract on the surfaces of non-woven fabrics fibers.
Preferably, in the preparation of component I, the rotational speed of the homogenizing mixer is 2500-3000rpm; in the process of dropwise adding ammonium persulfate, the homogenizing stirring speed of the component I is 2000-2200rpm.
By controlling the homogenizing rotating speed in the preparation process of the component I, the monomer components and the saussurea involucrata extract can be uniformly emulsified and dispersed under the action of an emulsifying agent and deionized water, so that the compatibility uniformity and the emulsification uniformity of the subsequent component I and the component II are improved, and the emulsification polymerization is promoted to prepare the cationic polymer nano particles loaded with the saussurea involucrata extract. And the dispersibility of the initiator in the process of dripping can be improved by controlling the homogeneous stirring rotating speed of the component I in the process of dripping ammonium persulfate, so that the emulsion polymerization efficiency is improved.
Preferably, the saussurea involucrata extract is prepared by the following steps:
cleaning herba Saussureae Involueratae, drying, pulverizing, and sieving with 60-100 mesh sieve;
adding pulverized herba Saussureae Involueratae into supercritical extraction equipment, and extracting with CO 2 As extraction fluid, collecting volatile oil and oil extract after supercritical fluid extraction to obtain herba Saussureae Involueratae extract.
Extracting effective components from herba Saussureae Involueratae with supercritical fluid, and extracting with CO 2 As extraction fluid, the critical temperature and critical pressure of extraction are lower, the operation condition is mild, the damage to the effective components is less, the effective components in the snow lotus can be stably extracted as much as possible, repeated extraction operation is not needed, and the loss of the effective components caused by the repeated extraction operation is reduced;in addition, CO 2 Stable property, high solubility, reduced oxidation of effective components, high content of extracted effective components, and CO 2 The extract of the saussurea involucrata extract is free of nitrate and harmful heavy metals and free of residual harmful solvents, so that the saussurea involucrata extract obtained by extraction is further prepared into saussurea involucrata emulsion, the saussurea involucrata emulsion is soaked into non-woven fabrics to prepare a functional core layer, and the sanitary towel prepared by the functional core layer is free of residual solvents, pollution to human bodies, safety and innocuity.
Preferably, in the supercritical fluid extraction, CO is controlled 2 The flow rate is 15-25L/h, the extraction temperature is 38-50 ℃, the extraction time is 2-3h, the extraction pressure is 15-25MPa, the separation temperature is 25-32 ℃, and the separation pressure is 3-6MPa.
By controlling the above condition parameters in the supercritical fluid extraction process, the effective components in herba Saussureae Involueratae can be extracted at lower extraction temperature and time, thereby reducing oxidation or loss of effective components in herba Saussureae Involueratae caused by high temperature and long time extraction process, and improving extraction rate of effective components.
In a second aspect, the present application provides a method for preparing a sanitary towel for alleviating cold in uterus, which adopts the following technical scheme:
a preparation method of a sanitary towel for relieving cold womb comprises the following steps:
soaking a sterilized non-woven fabric in herba Saussureae Involueratae emulsion for 30-50min, and drying to obtain functional core layer; sequentially stacking the surface layer, the functional core layer and the absorption layer, and then performing lamination treatment on the edge to obtain a composite layer;
attaching the bottom film layer to the surface of the composite layer, which is close to the absorption layer, and carrying out full-periphery edge sealing on the edge of the composite layer and the edge of the bottom film layer, and cutting and forming; then applying adhesive on the surface of the release paper layer, then attaching the release paper layer with the bottom film layer, transferring the adhesive to the bottom film layer, attaching an outer packaging film needle on the back surface of the release paper layer, packaging and sealing to obtain the finished product of the sanitary towel.
Through adopting above-mentioned technical scheme, can be with function sandwich layer stable setting in sanitary towel, and set up in the one side that is close to human private department skin to preferably set up in the middle part that corresponds sanitary towel, the banding of full week can make top layer, function sandwich layer, absorbed layer and carrier film connect layer upon layer stably, is difficult for appearing the phenomenon of interlayer separation, makes sanitary towel stable in use, feel good. Wherein, when menstrual blood in female physiological period is absorbed by the absorption layer, the penetration of menstrual blood into the absorption layer is promoted, and in the absorption process, the functional core layer is penetrated, when the functional core layer contacts with moisture in menstrual blood, the water-soluble film on the surface of the functional core layer is dissolved, and then the effective components of the herba saussureae involucratae extract are released, so that when the sanitary towel is used in physiological period, the external auxiliary conditioning of cold uterus is realized.
In summary, the present application has the following beneficial effects:
1. the snowflake emulsion containing the snowflake extract is adopted to infiltrate the non-woven fabrics, the functional core layer prepared after drying is further used for preparing the sanitary towel, and the effective components of the snowflake extract can be contacted with private parts of women in an external mode of using the sanitary towel in a physiological period of women, so that an external auxiliary conditioning effect is achieved, and discomfort caused by cold uterus in the physiological period of women is relieved.
2. The preparation method of the snow lotus emulsion is simple to operate, the process is easy to control, the prepared emulsion is stable in quality, can stably permeate and infiltrate into the non-woven fabric, and after drying treatment, ethanol components volatilize, so that the emulsion can form a water-soluble film on the surface of the non-woven fabric, the water-soluble film is contacted with moisture in menstrual blood of women in a physiological period to be dissolved, effective components of snow lotus extract coated by the water-soluble film and mint essential oil are released, and the effects of externally assisting in conditioning cold womb and dysmenorrhea are achieved.
3. The application adopts the supercritical fluid extraction mode to stably extract the active ingredients in the saussurea involucrata, and mixes the saussurea involucrata extract with a polymer monomer, so that in the emulsion polymerization process, the polymer nanoparticles adsorb and load the saussurea involucrata extract, and then the polymer nanoparticles loaded with the saussurea involucrata extract are further used for preparing the saussurea involucrata emulsion, when the saussurea involucrata emulsion infiltrates non-woven fabrics, the polymer nanoparticles can be stably adsorbed on non-woven fabrics fibers, the adhesiveness of the saussurea involucrata extract in the non-woven fabrics is improved, and the external auxiliary cold conditioning effect of the sanitary towel on human bodies is improved.
Drawings
Fig. 1 is a schematic structural view of a sanitary napkin for alleviating cold in uterus according to the present application;
fig. 2 is an exploded view of a sanitary napkin for alleviating cold in the uterus of the present application.
Reference numerals illustrate: 1. a surface layer; 2. a functional core layer; 3. an absorption layer; 4. a bottom film layer; 5. and (5) a release paper layer.
Detailed Description
The present application is described in further detail below in conjunction with figures 1-2 and examples.
Table 1 table of sources of partial raw materials in the embodiment
The source and the model of the materials are specifically selected from the materials in the support specific implementation mode, the materials are used for the test, and the source of the materials is not limited to the model of the manufacturer in the actual production process.
Preparation example of herba Saussureae Involueratae extract
Preparation example 1
A preparation method of herba Saussureae Involueratae extract comprises the following steps:
cleaning 100g of snow lotus herb, drying, crushing and sieving with a 60-mesh sieve;
adding pulverized herba Saussureae Involueratae into supercritical extraction equipment, and extracting with CO 2 As extraction fluid, control of CO 2 Extracting volatile oil and oil extract with supercritical fluid at flow rate of 15L/h at 50deg.C for 2 hr at 25MPa at separation temperature of 25deg.C under 6MPa to obtain herba Saussureae Involueratae extract.
Preparation example 2
A preparation method of herba Saussureae Involueratae extract comprises the following steps:
cleaning 100g of snow lotus herb, drying, crushing and sieving with a 80-mesh sieve;
adding pulverized herba Saussureae Involueratae into supercritical extraction equipment, and extracting with CO 2 As extraction fluid, control of CO 2 Extracting volatile oil and oil extract with supercritical fluid at flow rate of 20L/h, extraction temperature of 44 deg.C, extraction time of 2.5h, extraction pressure of 20MPa, separation temperature of 28 deg.C and separation pressure of 5MPa to obtain herba Saussureae Involueratae extract.
Preparation example 3
A preparation method of herba Saussureae Involueratae extract comprises the following steps:
cleaning 100g of snow lotus herb, drying, crushing and sieving with a 100-mesh sieve;
adding pulverized herba Saussureae Involueratae into supercritical extraction equipment, and extracting with CO 2 As extraction fluid, control of CO 2 Extracting volatile oil and oil extract with supercritical fluid at flow rate of 25L/h, extraction temperature of 50deg.C, extraction time of 3h, extraction pressure of 25MPa, separation temperature of 32deg.C and separation pressure of 3MPa to obtain herba Saussureae Involueratae extract.
Preparation example of snow lotus herb nano-composite
Preparation example 4
A preparation method of the snow lotus nanometer compound comprises the following steps:
adding 2g of cetyltrimethylammonium bromide into 500g of deionized water, and uniformly stirring; then adding 100g of styrene, 1g of acrylic acid, 5g of butyl acrylate and 40g of the saussurea involucrata extract prepared in preparation example 1, and stirring for 30min under the condition of 2500rpm to prepare a component I;
uniformly stirring 1g of cetyl trimethyl ammonium bromide, 0.5g of ammonium persulfate and 100g of deionized water to prepare a component II;
and (3) in a protective atmosphere, dropwise adding the component II into the component I while homogenizing and stirring, wherein the homogenizing and stirring speed is 2000rpm, carrying out heat preservation reaction after the dropwise adding is finished, sealing and preserving heat for 150min at the temperature of 70 ℃, cooling to below 40 ℃, and discharging to obtain the snow lotus nanometer compound.
Preparation example 5
A preparation method of the snow lotus nanometer compound comprises the following steps:
6g of cetyltrimethylammonium bromide is added into 560g of deionized water and stirred uniformly; then 130g of styrene, 3g of acrylic acid, 12g of butyl acrylate and 45g of the snow lotus herb extract prepared in preparation example 2 are added, and the mixture is stirred for 25 minutes in a homogenizing way under the condition of the rotating speed of 2800rpm to prepare a component I;
uniformly stirring 2g of cetyl trimethyl ammonium bromide, 1.0g of ammonium persulfate and 110g of deionized water to prepare a component II;
and (3) in a protective atmosphere, dropwise adding the component II into the component I while homogenizing and stirring, wherein the homogenizing and stirring speed is 2100rpm, carrying out heat preservation reaction after the dropwise adding is finished, sealing and preserving heat for 120min at the temperature of 75 ℃, cooling to below 40 ℃, and discharging to obtain the snow lotus nanometer compound.
Preparation example 6
A preparation method of the snow lotus nanometer compound comprises the following steps:
adding 8g of cetyltrimethylammonium bromide into 600g of deionized water, and uniformly stirring; then 150g of styrene, 5g of acrylic acid, 20g of butyl acrylate and 50g of the snow lotus herb extract prepared in preparation example 3 are added, and the mixture is stirred for 20min under the condition of 3000rpm to prepare a component I;
3g of cetyl trimethyl ammonium bromide, 1.5g of ammonium persulfate and 120g of deionized water are uniformly stirred to prepare a component II;
and (3) in a protective atmosphere, dropwise adding the component II into the component I while homogenizing and stirring, wherein the homogenizing and stirring speed is 2200rpm, carrying out heat preservation reaction after the dropwise adding is finished, sealing and preserving heat for 90min at the temperature of 80 ℃, cooling to below 40 ℃, and discharging to obtain the snow lotus nanometer compound.
Preparation example 7
A preparation method of the snow lotus nanometer compound comprises the following steps:
adding 4g of cetyltrimethylammonium bromide into 670g of deionized water, and uniformly stirring; then 65g of styrene, 1.5g of acrylic acid, 6g of butyl acrylate and 45g of the saussurea involucrata extract prepared in preparation example 2 are added, the mixture is stirred for 25min under the condition of the rotating speed of 2800rpm, then 0.6g of ammonium persulfate is added, the mixture is stirred uniformly, the temperature is raised to 75 ℃ in a sealed atmosphere, then 65g of styrene, 1.5g of acrylic acid and 6g of butyl acrylate are added, after the addition is finished, 4g of hexadecyl trimethyl ammonium bromide and 0.4g of ammonium persulfate are added, the mixture is sealed and kept at the temperature of 75 ℃ for 120min, and the mixture is discharged after the temperature is reduced to below 40 ℃ to prepare the saussurea involucrata nano-composite.
Preparation example of snow lotus flower emulsion
Preparation example 8
A preparation method of the snow lotus flower emulsion comprises the following steps:
adding 20g of an emulsifier (formed by mixing 15g of octadecyl polyoxyethylene ether biquaternary ammonium salt and 5g of dodecyl ammonium chloride) into 200g of an ethanol water solution with the mass fraction of 60%, uniformly stirring, then adding 20g of the saussurea involucrata nano compound prepared in preparation example 4 and 5g of peppermint essential oil, and performing ultrasonic dispersion for 12min under the condition of 15000Hz to prepare a mixture A; adding 10g of an emulsifier (formed by mixing 8g of octadecyl polyoxyethylene ether biquaternary ammonium salt and 2g of dodecyl ammonium chloride) into 550g of deionized water, uniformly stirring, then heating to 65 ℃, adding 60g of a stabilizer (formed by mixing 20g of carboxymethyl cellulose, 10g of sodium alginate, 4g of sodium starch octenyl succinate and 25g of modified starch), and uniformly stirring at the rotating speed of 2800rpm to prepare a mixture B;
cooling the mixture B to 62 ℃, adding the mixture A while homogenizing and stirring at 2800rpm, continuing homogenizing and stirring for 20min after the addition, adding 50g of 60% ethanol water solution, and homogenizing and stirring at 2800rpm for 15min to obtain the snow lotus emulsion.
Preparation examples 9 to 11
Preparation examples 9 to 11 differ from preparation example 8 described above in that: the types and the amounts of the emulsifying agents in the preparation process, the sources of the snow lotus nanometer compound and the difference of the parameters of the step conditions are shown in the following table 2:
TABLE 2 preparation conditions Table of snow lotus emulsion of preparation examples 8-11
Preparation example 12
The difference between this preparation and the above preparation 9 lies in: in the preparation of the mixture A, 8g of the snow lotus herb extract of the preparation example 2 and 12g of the cationic polymer nano particles are used for replacing 20g of the snow lotus herb nano compound prepared in the preparation example 4;
the cationic polymer nanoparticle is prepared by the following steps:
6g of cetyltrimethylammonium bromide is added into 560g of deionized water and stirred uniformly; then 130g of styrene, 3g of acrylic acid and 12g of butyl acrylate are added, and the mixture is stirred for 25 minutes in a homogenizing way under the condition that the rotating speed is 2800rpm, so that a component I is prepared;
uniformly stirring 2g of cetyl trimethyl ammonium bromide, 1.0g of ammonium persulfate and 110g of deionized water to prepare a component II;
and (3) in a protective atmosphere, dropwise adding the component II into the component I while homogenizing and stirring, wherein the homogenizing and stirring speed is 2100rpm, carrying out heat preservation reaction after the dropwise adding is finished, sealing and preserving heat for 120min at the temperature of 75 ℃, cooling to below 40 ℃, and discharging to obtain the cationic polymer nanoparticle.
Preparation example 13
The difference between this preparation and the above preparation 9 lies in: in the preparation of the mixture A, 20g of the snow lotus herb extract of preparation example 2 was used instead of 20g of the snow lotus herb nanocomposite of preparation example 4.
Examples
Example 1
A preparation method of a sanitary towel for relieving cold womb comprises the following steps:
soaking a sterilized non-woven fabric (length 5cm, width 3cm, and thickness 1cm, selected from Shandong Hua industry non-woven fabrics Co., ltd.) in the herba Saussureae Involueratae emulsion prepared in preparation example 8 at room temperature for 30min, and drying to obtain functional core layer 2;
sequentially stacking the surface layer 1, the functional core layer 2 and the absorption layer 3, and then performing lamination treatment on the edge to obtain a composite layer;
attaching the bottom film layer 4 to the surface of the composite layer, which is close to the absorption layer, and carrying out full-periphery edge sealing on the edge of the composite layer and the edge of the bottom film layer 4, and cutting and forming; then applying adhesive on the surface of the release paper layer 5, then attaching the release paper layer to the bottom film layer 4, transferring the adhesive to the bottom film layer 4, attaching an outer packaging film needle on the back of the release paper layer 5, packaging, and sealing to obtain the finished product of the sanitary towel, wherein the finished product of the sanitary towel is shown in figures 1-2.
Examples 2 to 6
Examples 2-6 differ from example 1 in that: the origin differences of the snow lotus emulsion are shown in the following table 3:
table 3 snow lotus emulsion Source Table of examples 1-6
Comparative example
Comparative example 1
This comparative example differs from example 2 above in that: the functional core layer 2 is not soaked by the snow lotus emulsion.
Comparative example 2
This comparative example differs from example 2 above in that: the functional core layer 2 is soaked by adopting a snowflake extract dispersion liquid, and the snowflake extract dispersion liquid is prepared by mixing 8g of the snowflake extract of the preparation example 2 with 50g of an ethanol aqueous solution with the mass fraction of 65%.
Performance test
Rutin content test
The functional core 22 prepared in examples 1 to 6 and comparative example 2 was measured for rutin content, and the rutin content was measured on the day after preparation, after 30 days of storage, after 60 days of storage, and after 90 days of storage, respectively, and was measured with specific reference to the high performance liquid chromatography (general rule 0512) of the "chinese pharmacopoeia".
The measurement results are shown in the following table 4:
TABLE 4 rutin content in functional core layer 22 prepared in examples 1-6 and comparative example 2
As can be seen from the above table 4 in combination with examples 1-6, the functional core layer 2 prepared by impregnating the snowflake emulsion containing the snowflake in advance into the non-woven fabric can be stably loaded with the effective component of the snowflake extract, namely rutin, and after 30 days of storage, 60 days of storage and 90 days of storage, the content loss of rutin is lower than 4%, which indicates that the prepared functional core layer 2 is adopted to further prepare the sanitary towel, so that the content of the effective component can be kept higher within the storage shelf life of the sanitary towel, and the effective component of the snowflake extract is contacted with the private parts of women in an external application mode of the sanitary towel during the physiological period of women, thereby playing an auxiliary conditioning role for external application and relieving discomfort caused by cold uterus during the physiological period of women.
Wherein, in examples 1-4, the saussurea involucrata extract is added into the emulsification polymerization process of the cationic polymer nano particles, the prepared saussurea involucrata nano compound is further used for preparing saussurea involucrata emulsion, the saussurea involucrata emulsion is further used for infiltrating the non-woven fabric, the rutin content loss in the functional core layer 2 prepared in examples 1-3 is lower than 3%, and the rutin content loss in example 4 is lower than 3.3%, which indicates that the loading rate of the saussurea involucrata extract on the cationic polymer nano particles can be improved in the emulsification polymerization process of adding the saussurea involucrata extract into the cationic polymer nano particles, the adsorption adhesiveness of the cationic polymer nano particles adsorbed with the saussurea involucrata extract on the surface of the non-woven fabric fiber can be improved, and the loss of active ingredients in the saussurea involucrata extract during storage can be slowed down.
In addition, in example 5, the non-woven fabric is soaked by using the snow lotus emulsion prepared by mixing the snow lotus extract of preparation example 2 and the cationic polymer nano particles, and the rutin content reduction rate after 30 days of storage, 60 days of storage and 90 days of storage is higher than that of example 2; in example 6, only the snow lotus herb emulsion prepared by directly adopting the snow lotus herb extract is not adopted, the cationic polymer nano particles are not adopted as a load carrier, the snow lotus herb emulsion is utilized to infiltrate the non-woven fabric, and the rutin content reduction rate after 30 days of storage, 60 days of storage and 90 days of storage is higher than that of example 2. The above description shows that, the cationic polymer nanoparticles are used as the loading carrier of the saussurea involucrata extract, and the saussurea involucrata extract is preferably mixed with the polymerization monomer, so that the saussurea involucrata extract can be stably adsorbed in the emulsification polymerization process, the saussurea involucrata extract is loaded in the cationic polymer nanoparticles to form the saussurea involucrata nanocomposite, on one hand, the loading rate of the saussurea involucrata extract on the cationic polymer nanoparticles can be improved, and on the other hand, the adsorption and adhesiveness of the cationic polymer nanoparticles loaded with the saussurea involucrata extract on the surface of the non-woven fabric fiber can be improved, and the loss of active ingredients in the saussurea involucrata extract during storage can be slowed down.
In comparative example 2, the dispersion of the saussurea involucrata extract obtained by mixing the saussurea involucrata extract with the aqueous solution of ethanol is used for soaking the non-woven fabric, the rutin content in the prepared functional core layer 2 is higher than that in example 2, and the rutin content reduction rate after 30 days of storage, 60 days of storage and 90 days of storage is higher than that in example 2, which means that the saussurea involucrata extract is added into the emulsion polymerization process of the cationic polymer nano particles, the prepared saussurea involucrata nano compound is further used for preparing the saussurea involucrata emulsion, and the saussurea involucrata emulsion is further used for soaking the non-woven fabric, so that the adsorption and adhesiveness of the saussurea involucrata extract on the surface of the non-woven fabric fiber can be improved, and the loss of the effective components in the saussurea involucrata extract can be slowed down during the storage.
(II) evaluation of use
The sanitary napkins prepared in example 2 and comparative example 1 were tested on a trial of volunteer staff, 16 women in total, divided into two groups of 8 women each, the first group of staff continuously used the sanitary napkin prepared in example 2 for three months, and the second group of staff continuously used the sanitary napkin prepared in comparative example 1 for three months.
Wherein, the first group personnel condition is respectively: two years old (average physiological period of three months is 7 days), one year old 23 (average physiological period of three months is 7 days), one year old 27 (average physiological period of three months is 8 days), two years old 30 (average physiological period of three months is 7 days), one year old 35 (average physiological period of three months is 6 days), one year old 38 (average physiological period of three months is 6 days);
the second group of personnel conditions are respectively: two ages 23 (average physiological period of three months is 7 days), two ages 26 (average physiological period of three months is 8 days), two ages 30 (average physiological period of three months is 7 days), one year 33 (average physiological period of three months is 6 days), and one year 36 (average physiological period of three months is 7 days).
The two groups of staff were interviewed for the use conditions and effects after two months and three months of using the sanitary towel, and the use evaluation was summarized as shown in the following table 5:
table 5 evaluation of sanitary napkins made in example 2 and comparative example 1
As is clear from Table 5, the sanitary napkin further prepared by using the functional core layer 2 containing the snow lotus herb extract of the present invention has a slight cooling sensation during use, and the peppermint oil component of the functional core layer 2 possibly has a cooling effect on the skin, so that the use stuffiness sensation of the sanitary napkin during menstruation of women can be reduced to a certain extent; the blood clot during menstruation of women tends to be reduced after two months and three months of use, which means that the sanitary towel further prepared by the functional core layer 2 containing the saussurea involucrata extract has a certain external auxiliary cold-uterus conditioning effect during use.
The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.
Claims (5)
1. A sanitary napkin for alleviating cold in uterus, which is characterized in that: the sanitary towel comprises a surface layer (1), a functional core layer (2), an absorption layer (3), a bottom film layer (4) and a release paper layer (5) which are sequentially arranged from the upper surface to the lower surface, wherein the functional core layer (2) is prepared by immersing non-woven fabrics into snow lotus emulsion and drying;
the snow lotus emulsion is prepared through the following steps:
adding 2-3 parts by weight of an emulsifier into 20-30 parts by weight of ethanol water solution, uniformly stirring, then adding 2-3 parts by weight of a saussurea involucrata nano compound and 0.5-1.0 part by weight of peppermint essential oil, and uniformly dispersing by ultrasonic waves to prepare a mixture A;
adding 1-1.2 parts by weight of an emulsifier into 55-60 parts by weight of deionized water, uniformly stirring, then heating to 65-70 ℃, adding 6-8 parts by weight of a stabilizer, and uniformly stirring to obtain a mixture B;
cooling the mixture B to 55-62 ℃, adding the mixture A while homogenizing and stirring, continuing homogenizing and stirring for 20-30min after the addition, then adding 5-10 parts by weight of ethanol water solution, homogenizing and stirring for 10-15min, and obtaining the snow lotus emulsion;
in the preparation of the mixture A and the preparation of the mixture B, each weight part of the emulsifier is formed by mixing octadecyl polyoxyethylene ether biquaternary ammonium salt and dodecyl ammonium chloride according to the weight ratio of 2-4:1;
each weight part of the stabilizer comprises 2-3 weight parts of carboxymethyl cellulose, 1-2 weight parts of sodium alginate, 0.3-1.0 weight parts of sodium starch octenyl succinate and 1.5-2.5 weight parts of modified starch;
in the preparation of the mixture A, the mass fraction of the ethanol water solution is 60-70%; the ultrasonic frequency of ultrasonic dispersion is 15000-18000Hz, and the ultrasonic time is 10-12min;
in the preparation of the mixture B, the homogenizing stirring rotating speed is 2800-4000rpm;
in the process of adding the mixture A into the mixture B, the homogenizing stirring rotating speed is 2800-3200rpm, and the homogenizing stirring rotating speed after the mixture A is added is 2800-4000rpm;
after the mixture A is completely added into the mixture B, the mass fraction of the ethanol aqueous solution is 60-70%;
the snow lotus nanometer compound is prepared through the following steps:
adding 0.2-0.8 weight part of hexadecyl trimethyl ammonium bromide into 50-60 weight parts of deionized water, and uniformly stirring; then adding 10-15 parts by weight of styrene, 0.1-0.5 part by weight of acrylic acid, 0.5-2 parts by weight of butyl acrylate and 4-5 parts by weight of herba saussureae involucratae extract, and stirring for 20-30min to obtain a component I;
uniformly stirring 0.1-0.3 part by weight of hexadecyl trimethyl ammonium bromide, 0.05-0.15 part by weight of ammonium persulfate and 10-12 parts by weight of deionized water to prepare a component II;
and (3) in a protective atmosphere, dropwise adding the component II into the component I while homogenizing and stirring, after the dropwise adding is finished, carrying out heat preservation reaction, sealing and preserving heat for 90-150min at 70-80 ℃, cooling to below 40 ℃, and discharging to obtain the snow lotus nanocomposite.
2. A sanitary napkin for alleviating cold of the uterus as claimed in claim 1, wherein: in the preparation of the component I, the rotation speed of homogenizing stirring is 2500-3000rpm; in the process of dropwise adding ammonium persulfate, the homogenizing stirring speed of the component I is 2000-2200rpm.
3. A sanitary napkin for alleviating cold of the uterus as claimed in claim 2, wherein: the saussurea involucrata extract is prepared by the following steps:
cleaning herba Saussureae Involueratae, drying, pulverizing, and sieving with 60-100 mesh sieve;
adding pulverized herba Saussureae Involueratae into supercritical extraction equipment, and extracting with CO 2 As extraction fluid, collecting volatile oil and oil extract after supercritical fluid extraction to obtain herba Saussureae Involueratae extract.
4. A sanitary napkin for alleviating cold of the uterus as claimed in claim 3, wherein: in the supercritical fluid extraction, CO is controlled 2 The flow rate is 15-25L/h, the extraction temperature is 38-50 ℃, the extraction time is 2-3h, the extraction pressure is 15-25MPa, the separation temperature is 25-32 ℃, and the separation pressure is 3-6MPa.
5. A method of making a sanitary napkin according to any one of claims 1-4, wherein the cold-in-the-uterus alleviation is characterized by: the method comprises the following steps:
soaking a sterilized non-woven fabric in herba Saussureae Involueratae emulsion for 30-50min, and drying to obtain functional core layer (2);
after the surface layer (1), the functional core layer (2) and the absorption layer (3) are sequentially stacked, laminating treatment is carried out on the edge to obtain a composite layer;
attaching a bottom film layer (4) to the surface of the composite layer, which is close to the absorption layer, and carrying out full peripheral edge sealing on the edge of the composite layer and the edge of the bottom film layer, and cutting and forming; then applying adhesive on the surface of the release paper layer (5), then attaching the release paper layer to the bottom film layer (4), transferring the adhesive to the bottom film layer (4), attaching an outer packaging film needle on the back of the release paper layer (5), packaging and sealing to obtain the finished product of the sanitary towel.
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| WO2002026272A1 (en) * | 2000-09-29 | 2002-04-04 | Salvona L.L.C. | Multi component controlled release system for sanitary paper products |
| CN101289601A (en) * | 2008-05-30 | 2008-10-22 | 江苏工业学院 | Cationic binder emulsion for coating coloring, preparation method and uses |
| CN108094446A (en) * | 2017-12-18 | 2018-06-01 | 徐州医科大学 | A kind of Chinese medicine air purifying spraying agent based on microemulsion technology and preparation method thereof |
| CN112546101A (en) * | 2020-12-24 | 2021-03-26 | 河南永辉电子商务有限公司 | Traditional Chinese medicine compound for relieving eczema, sustained-release agent, preparation method and application |
| CN215273901U (en) * | 2021-07-29 | 2021-12-24 | 东莞市金保利卫生用品有限公司 | Sanitary towel for recuperating and detoxifying |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9132194B2 (en) * | 2011-07-12 | 2015-09-15 | Warsaw Orthopedic, Inc. | Medical devices and methods comprising an adhesive sheet containing a drug depot |
| EP3266472A1 (en) * | 2016-07-08 | 2018-01-10 | Mölnlycke Health Care AB | A medical dressing comprising a carrier and a composite material |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002026272A1 (en) * | 2000-09-29 | 2002-04-04 | Salvona L.L.C. | Multi component controlled release system for sanitary paper products |
| CN101289601A (en) * | 2008-05-30 | 2008-10-22 | 江苏工业学院 | Cationic binder emulsion for coating coloring, preparation method and uses |
| CN108094446A (en) * | 2017-12-18 | 2018-06-01 | 徐州医科大学 | A kind of Chinese medicine air purifying spraying agent based on microemulsion technology and preparation method thereof |
| CN112546101A (en) * | 2020-12-24 | 2021-03-26 | 河南永辉电子商务有限公司 | Traditional Chinese medicine compound for relieving eczema, sustained-release agent, preparation method and application |
| CN215273901U (en) * | 2021-07-29 | 2021-12-24 | 东莞市金保利卫生用品有限公司 | Sanitary towel for recuperating and detoxifying |
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