CN105943521A - Diatomite carrying taxinol functional non-woven fabric core - Google Patents
Diatomite carrying taxinol functional non-woven fabric core Download PDFInfo
- Publication number
- CN105943521A CN105943521A CN201610466165.7A CN201610466165A CN105943521A CN 105943521 A CN105943521 A CN 105943521A CN 201610466165 A CN201610466165 A CN 201610466165A CN 105943521 A CN105943521 A CN 105943521A
- Authority
- CN
- China
- Prior art keywords
- paclitaxel
- woven fabric
- functional non
- tripolite loading
- taxinol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Botany (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a diatomite carrying taxinol functional non-woven fabric core which is obtained by coating spunlace non-woven fabric of pure viscose fiber with paste. The paste is prepared from the following substances: taxinol, diatomite, menthol, stearic acid, glycerol, lanolin, liquid paraffin, octadecanol, triethanolamine and water. The functional core is split into sheets according to the needed specification to be loaded on disposable sanitary articles and to be applied to the human body, and the action of health and human immunity improving is achieved.
Description
Technical field
The present invention relates to disposable sanitary articles field, particularly relate to a kind of tripolite loading paclitaxel functional non-woven fabric
Chip.
Background technology
Paclitaxel in Ramulus et folium taxi cuspidatae Extract has the active anticancer of uniqueness, and in 1992, U.S. FDA passed through paclitaxel
Certification as PTS.
Paclitaxel is polymerized by promotion, prevention microtubule depolymerization, thus the division of anticancer.Can dissolve in blood vessel simultaneously
Metabolism of lipid and cholesterol, allow erythrocyte carry more oxygen and nutrient to whole body, for hypertension. hyperlipidemia. hyperglycemia
Regulation effect is had etc. disease.
Paclitaxel is as cancer patient's standard chemotherapeutic agents, and it is big that it exists side effect, is only suitable for use during chemotherapy, additionally
Chemotherapy stage terminates, and medicine is the most just stopped using.Recently as being found of other medical values of paclitaxel, begin with people's research
The application of its Transdermal absorption, as the effective measures reducing toxic and side effects.The side effect that paclitaxel injection is common: 80%
User can lose hair, the user of 18.2% has pain reaction, and the most special body constitution (hypertension, diabetes, Peptic Ulcers) exists
Use paclitaxel injection can produce super anaphylaxis, cause using.
Transdermal drug delivery system is a kind of technical scheme being totally different from conventional administration mode, the minimizing people of energy amplitude peak
The side reaction of body, single-dose amount is few simultaneously, and administration time is long, and side effect is little, is more suitable for daily nursing health care and uses.Transdermal
Being administered completely can be without the solubilizing agent of paclitaxel: polyoxyethylene castor oil, directly reduces because using polyoxyethylene caster
The human body side reaction that oil causes.
Although transdermal administration can be substantially reduced side reaction, but as how can be controlled speed. stable to internal defeated
Send paclitaxel, same particular importance.Find that kieselguhr has meaning especially for the transporting velocity of stability contorting paclitaxel under study for action
Justice, has no special event both at home and abroad.
Research is a kind of easy to use, and the tripolite loading paclitaxel functional non-woven fabric chip that Transdermal absorption is administered just has important
Meaning.
Summary of the invention
The present invention is the daily use in order to solve paclitaxel, promotes the Transdermal absorption of paclitaxel, it is to avoid the poison of paclitaxel
Side effect.The open a kind of tripolite loading paclitaxel functional non-woven fabric chip of the present invention, it be pure viscose fiber spun lacing without
Spin a kind of paste of coating on cloth.Then cutting in flakes by this non-woven fabrics by required specification, this paclitaxel diatom functional chip is born
It is loaded on surface layer or the sublevel of disposable sanitary articles, is pasted on human body, there is health care and improve the effect of body immunity,
Also having the effect of easing pain and diminishing inflammation, prevention and daily nursing for cancer, particularly breast carcinoma have positive effect simultaneously.
The technical scheme is that: mix up paste by formula, paste formulation forms: paclitaxel 0.005-0.05%,
Kieselguhr 5-20%, menthol 0.05-0.5%, stearic acid 1-10%, glycerol 1-5%,
Lanoline 0.5-5%, liquid paraffin 1-10%, octadecanol 0.2-2%, triethanolamine 0.5-5%, deionized water surplus.
The present invention paste modulation uniformly after, by being (10-30) with pure viscose fiber spun-laced nonwoven fabric mass ratio:
(90-70) coat on pure viscose fiber spun-laced nonwoven fabric.
The tripolite loading paclitaxel functional non-woven fabric chip of the present invention is cut into tablet by different product specification, negative
It is loaded in disposable sanitary articles surface or sublevel can obtain the disposable sanitary articles containing paclitaxel diatom function, for human body
Nursing.
Tripolite loading paclitaxel functional non-woven fabric chip dies is cut into roundel, and on breast pad production line, PUR is fixed
It is positioned at breast pad surface, paclitaxel diatom breast pad can be produced, for chest health；By slitting for paclitaxel functional chip
Shape thing, on production line of toilet napkin, PUR is positioned sanitary towel's surface layer or sublevel, can produce paclitaxel diatom function and defend
Raw towel, keeps healthy for reproductive system.
The invention has the beneficial effects as follows, use menthol, stearic acid, glycerol, lanoline, liquid paraffin, mixing of octadecanol
Close dissolution system and dissolve paclitaxel；Being dissolved by mixed system, stable by tripolite loading, after adding pure water, paclitaxel is same
Sample keeps stable, does not separate out.Whole paste is designed as lipophilic ulsions, beneficially paclitaxel infiltration.Simultaneously in order to controlled
Release, uses kieselguhr as taxadol slow release controlling agent.By kieselguhr controlled release paclitaxel, improve relaxing of skin feel
Adaptive, it is to avoid zest.
In order to verify that the present invention reduces the toxic and side effects of product, by " disinfection technology standard ", New Zealand TWO is used to do
Patch zest is tested, and patch area 2.5 centimetres * 2.5 centimetres, 1 hour .24 hour .48 hour testing time, test result is such as
Following table.
Test result, the paclitaxel diatom functional chip nonirritant of the present invention.
In order to verify the stable controlled velocity of tripolite loading paclitaxel functional non-woven fabric chip of the present invention, use New Zealand
TWO is cooked the test of patch infiltration rate, patch area 2.5 centimetres * 2.5 centimetres, test 15 minutes, 1 hour, 4 hours, 12 little
Time, 24 hours, the content of paclitaxel in the tripolite loading paclitaxel functional non-woven fabric chip in patch after 48 hours, by purple
Remain the change of content of taxol after the Transdermal absorption of China fir alcohol, draw the rate of release change of paclitaxel.Content of taxol is tested
Method HPLC(high performance liquid chromatography).Option A mastic formula is added without kieselguhr, quantity deionized water polishing, adjust glutinous
Spend basically identical with option b.Option b mastic formula adds kieselguhr.
Test result such as following table.
Test result, paclitaxel in the tripolite loading paclitaxel functional non-woven fabric chip of option b (addition kieselguhr)
Rate of release is more steady.Option A is distinguished the most over the course of 15 mins, after 1 hour, after 4 hours, after 12 hours, after 24 hours, and 48 hours
Rear paclitaxel Transdermal absorption 5.88%, 11.27%, 18.64%, 33.82%, 53.43%, 58.82%.And option b is respectively at 15 points
Zhong Hou, after 1 hour, after 4 hours, after 12 hours, after 24 hours, paclitaxel Transdermal absorption 4.41%, 7.35% after 48 hours,
15.7%, 29.9%, 45.59%, 57.35%.Add the kieselguhr infiltration rate for control paclitaxel, particularly control the initial stage
Infiltration rate, has obvious effect, reaches the purpose steadily discharged, and to the later stage, nor affects on the total amount of Transdermal absorption.
Detailed description of the invention
Embodiment 1
5.94 kilograms of stearic acid, 2.47 kg of glycerin, 0.99 kilogram of Pilus Caprae seu Ovis is added in 50 liters of rustless steel chuck heating and stirring pots
Fat, 6.93 kg liquid paraffin, 0.99 kilogram of octadecanol, open stirring paddle, 60 degrees Celsius 30 minutes.It is subsequently adding menthol
1.1 kilograms, paclitaxel 0.01 kilogram, 60 degrees Celsius 30 minutes.Adding 10 kilograms of kieselguhr, stirring is cooled to 45 degrees Celsius.
Discharging, rolls one time with three-roller.Transfer the material in 150 liters of dispersion cylinder the most again, open high speed dispersor, dispersion limit, limit
Add the mixed liquor being made up of 69.59 kilograms of deionized waters and 1.98 kilograms of triethanolamine, feed complete, disperse 15 minutes, go out
Material, produces the paste being coated with.
Preparing 500 kilograms of pure viscose fiber spun laced fabrics, fabric width 1 meter, grammes per square metre 80 grams/m, by every square metre of non-woven fabrics
20 grams of pastes of upper coating, complete coating on circular screen printer.Obtain a kind of tripolite loading paclitaxel functional non-woven fabric core
Sheet.
On breast pad production line, tripolite loading paclitaxel functional non-woven fabric chip dies is cut into the disk of 13 centimetres, heat
The melten gel back side is positioned breast pad surface, thus obtains a kind of breast pad containing paclitaxel diatom function.
Embodiment 2
3.10 kilograms of stearic acid, 1.15 kg of glycerin, 1.80 kilograms of Pilus Caprae seu Oviss are added in 20 liters of rustless steel chuck heating and stirring pots
Fat, 3.00 kg liquid paraffin, 0.55 kilogram of octadecanol, open stirring paddle, 60 degrees Celsius 30 minutes.It is subsequently adding menthol
0.50 kilogram, paclitaxel 0.03 kilogram, 60 degrees Celsius 30 minutes.Adding 6 kilograms of kieselguhr, stirring is cooled to 45 degrees Celsius.
Discharging, rolls one time with three-roller.Transfer the material in 150 liters of dispersion cylinder the most again, open high speed dispersor, dispersion limit, limit
Add the mixed liquor being made up of 82.87 kilograms of deionized waters and 1.00 kilograms of triethanolamine, feed complete, disperse 15 minutes, go out
Material, produces the paste being coated with.
Preparing 500 kilograms of pure viscose fiber spun laced fabrics, fabric width 1 meter, grammes per square metre 60 grams/m, by every square metre of non-woven fabrics
10 grams of pastes of upper coating, complete coating on circular screen printer.Obtain a kind of tripolite loading paclitaxel functional non-woven fabric core
Sheet.
On production line of toilet napkin, will be containing the tripolite loading paclitaxel crosscutting one-tenth of functional non-woven fabric chip 3 centimetres * 8 lis
The rectangle tablet of rice, the PUR back side is positioned sanitary towel's sublevel, thus obtains a kind of containing paclitaxel diatom function
Sanitary towel.
Embodiment 3
6.00 kilograms of stearic acid, 2.35 kg of glycerin, 0.70 kilogram of Pilus Caprae seu Ovis is added in 50 liters of rustless steel chuck heating and stirring pots
Fat, 3.00 kg liquid paraffin, 0.55 kilogram of octadecanol, open stirring paddle, 60 degrees Celsius 30 minutes.It is subsequently adding menthol
1.20 kilograms, paclitaxel 0.04 kilogram, 60 degrees Celsius 30 minutes.Adding 12 kilograms of kieselguhr, it is Celsius that stirring is cooled to 45
Degree.Discharging, a piece of with three-roller rolling.Transfer the material in 150 liters of dispersion cylinder the most again, open high speed dispersor, while divide
Dissipate limit and add the mixed liquor being made up of 72.66 kilograms of deionized waters and 1.50 kilograms of triethanolamine, feed complete, disperse 15 points
Clock, discharging, produce the paste being coated with.
Preparing 500 kilograms of pure viscose fiber spun laced fabrics, fabric width 1 meter, grammes per square metre 60 grams/m, by every square metre of non-woven fabrics
15 grams of pastes of upper coating, complete coating on circular screen printer.Obtain a kind of tripolite loading paclitaxel functional non-woven fabric core
Sheet.
On breast pad production line, will be containing the tripolite loading paclitaxel crosscutting one-tenth of functional non-woven fabric chip 3 centimetres * 3 centimetres
Square tablet, the PUR back side is positioned the sublevel of breast pad, thus obtains a kind of breast containing paclitaxel diatom function
Pad.
Claims (3)
1. a functional non-woven fabric chip for tripolite loading paclitaxel, it is uniform on the spun-laced nonwoven fabric of pure viscose fiber
One layer of paste containing tripolite loading paclitaxel of ground coating.
A kind of tripolite loading paclitaxel functional non-woven fabric chip the most according to claim 1, it is characterised in that described
Paste containing tripolite loading paclitaxel is to use following percentage by weight formula:
Paclitaxel 0.005-0.05%,
Kieselguhr 5-20%,
Menthol 0.5-5%,
Stearic acid 1-10%,
Glycerol 1-10%,
Lanoline 0.5-5%,
Liquid paraffin 1-10%,
Octadecanol 0.2-2%,
Triethanolamine 0.5-5%,
Deionized water surplus.
A kind of tripolite loading paclitaxel functional non-woven fabric chip the most according to claim 1, it is characterised in that be coated in
Paste on non-woven fabrics with the percentage by weight of non-woven fabrics is: (10-30): (90-70).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610466165.7A CN105943521B (en) | 2016-06-24 | 2016-06-24 | A kind of functional non-woven fabric chip of tripolite loading taxol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610466165.7A CN105943521B (en) | 2016-06-24 | 2016-06-24 | A kind of functional non-woven fabric chip of tripolite loading taxol |
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| Publication Number | Publication Date |
|---|---|
| CN105943521A true CN105943521A (en) | 2016-09-21 |
| CN105943521B CN105943521B (en) | 2019-03-29 |
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| CN201610466165.7A Active CN105943521B (en) | 2016-06-24 | 2016-06-24 | A kind of functional non-woven fabric chip of tripolite loading taxol |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108478552A (en) * | 2018-05-27 | 2018-09-04 | 王艳萍 | A kind of preparation method of eyeshield composite cream |
| CN109137485A (en) * | 2018-08-31 | 2019-01-04 | 张欢 | A kind of multifunctional non-woven fabric and its application for driving peculiar smell with anti-aging |
| CN112160172A (en) * | 2020-10-16 | 2021-01-01 | 东莞市英中新材料科技有限责任公司 | Slow-release taxol nonwoven fabric material with antibacterial and odor-removing functions and preparation method thereof |
| CN112680961A (en) * | 2021-01-08 | 2021-04-20 | 中健生命科技(深圳)有限公司 | Non-woven fabric chip with slow-release tea polyphenol |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102631700A (en) * | 2011-02-15 | 2012-08-15 | 粟时献 | Nano-taxus chinensis series health-care daily chemical hygienic product and manufacture method thereof |
| CN205108076U (en) * | 2015-10-26 | 2016-03-30 | 天津沐弘玖致科技有限公司 | Sanitary towel that contains diatom magnetism anion sandwich layer |
-
2016
- 2016-06-24 CN CN201610466165.7A patent/CN105943521B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102631700A (en) * | 2011-02-15 | 2012-08-15 | 粟时献 | Nano-taxus chinensis series health-care daily chemical hygienic product and manufacture method thereof |
| CN205108076U (en) * | 2015-10-26 | 2016-03-30 | 天津沐弘玖致科技有限公司 | Sanitary towel that contains diatom magnetism anion sandwich layer |
Non-Patent Citations (2)
| Title |
|---|
| HONGBO ZHANG ET AL: ""Diatom silica microparticles for sustained release and permeation enhancement following oral delivery of prednisone and mesalamine"", 《BIOMATERIALS》 * |
| 郭秀瑞等: ""硅藻土作为抗菌剂载体的应用研究"", 《中国粉体技术》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108478552A (en) * | 2018-05-27 | 2018-09-04 | 王艳萍 | A kind of preparation method of eyeshield composite cream |
| CN109137485A (en) * | 2018-08-31 | 2019-01-04 | 张欢 | A kind of multifunctional non-woven fabric and its application for driving peculiar smell with anti-aging |
| CN112160172A (en) * | 2020-10-16 | 2021-01-01 | 东莞市英中新材料科技有限责任公司 | Slow-release taxol nonwoven fabric material with antibacterial and odor-removing functions and preparation method thereof |
| CN112680961A (en) * | 2021-01-08 | 2021-04-20 | 中健生命科技(深圳)有限公司 | Non-woven fabric chip with slow-release tea polyphenol |
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| Publication number | Publication date |
|---|---|
| CN105943521B (en) | 2019-03-29 |
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Effective date of registration: 20210322 Address after: 518110 Room 203, unit 3, 34 Dahe Industrial Zone, Guancheng community, Guanhu street, Longhua District, Shenzhen City, Guangdong Province Patentee after: Zhongjian Life Technology (Shenzhen) Co.,Ltd. Address before: 518110 Yili research and development base, dashuikeng Ercun, Guanlan street, Longhua New District, Shenzhen City, Guangdong Province Patentee before: SHENZHEN YILI ENVIRONMENTAL PROTECTION TECHNOLOGY Co.,Ltd. |
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