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CN115356494B - Full-automatic biochemical analyzer - Google Patents

Full-automatic biochemical analyzer Download PDF

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Publication number
CN115356494B
CN115356494B CN202210986481.2A CN202210986481A CN115356494B CN 115356494 B CN115356494 B CN 115356494B CN 202210986481 A CN202210986481 A CN 202210986481A CN 115356494 B CN115356494 B CN 115356494B
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China
Prior art keywords
sample
needle
reagent
hand
module
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CN202210986481.2A
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Chinese (zh)
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CN115356494A (en
Inventor
许行尚
杰弗瑞·陈
胡统号
郭金龙
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Nanjing Lanyu Biological Technology Co Ltd
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Nanjing Lanyu Biological Technology Co Ltd
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Priority to CN202210986481.2A priority Critical patent/CN115356494B/en
Publication of CN115356494A publication Critical patent/CN115356494A/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/0092—Scheduling
    • G01N35/0095—Scheduling introducing urgent samples with priority, e.g. Short Turn Around Time Samples [STATS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004—Cleaning sample transfer devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The invention discloses a full-automatic biochemical analyzer, which comprises a sample injection module, a sample filling module, a reagent filling module, a reaction and detection module, a stirring and mixing module and a reaction cup cleaning module, wherein the sample injection module is used for injecting a sample; the sample filling module, the reagent filling module, the reaction and detection module, the stirring and mixing module and the reaction cup cleaning module are all arranged on the base; the sample injection module transmits a sample to be detected to a preset sampling position, and the sample to be detected is moved to the reaction and detection module for detection through the sample filling module; the reaction cup cleaning module is used for cleaning the reaction cup; the sample feeding modules comprise a plurality of sample racks, and two adjacent sample feeding modules are spliced together, so that the sample racks are transmitted to positions farther than a preset sampling position through the spliced sample feeding modules; the full-automatic biochemical analyzer is provided with an operation screen. The operation mode of the sample injection module is relatively independent, and the sample injection module can be adapted to other detection instruments to detect samples in a pipelining mode.

Description

Full-automatic biochemical analyzer
The application relates to a split application of Chinese application patent application with the application number of 202210666332.8 and the application date of 2022, 06 and 14, and the application name of full-automatic biochemical analyzer.
Technical Field
The invention belongs to the technical field of biochemical analysis and detection, and particularly relates to a full-automatic biochemical analyzer.
Background
Biochemical analyzers, also commonly referred to as biochemicals, are instruments that use the principle of optoelectric colorimetry to measure a specific chemical composition in a body fluid. The method has the advantages of high measurement speed, high accuracy and small consumption of reagents, and is widely used in hospitals, epidemic prevention stations and family planning service stations at all levels. The efficiency and the income of the conventional biochemical test can be greatly improved by the matched use.
After the first full-automatic biochemical analyzer in the world was successfully produced in 1957 by Technicon corporation in the United states, full-automatic biochemical analyzers with different models and functions are continuously emerging, and an important step is provided for the automation of clinical biochemical examination of hospitals. Since the first introduction of a clinical biochemical analyzer in the 50 s skeggs, various biochemical automatic analyzers and diagnostic reagents have been greatly developed along with the development of science and technology, particularly medical science, and can be divided into: continuous flow (ducted), discrete, split, and dry-sheet.
The Chinese patent document CN110208559A discloses a biochemical analyzer, which comprises a frame, a detection mechanism for detecting a sample, a sample transmission mechanism for feeding the sample onto the detection mechanism, and a reagent feeding mechanism for adding a reaction reagent into the detection mechanism; the sample transmission mechanism comprises a test tube rack, a transmission rack, a feeding area for feeding, a material taking area for a detection mechanism to absorb materials in a test tube, a discharging area for discharging and a material moving device for moving the test tube rack; the feeding area, the discharging area, the material taking area and the material moving device are all arranged on the frame; the reagent feeding mechanism comprises a reagent cylinder rotationally connected with the frame, a plurality of reagent boxes arranged on the reagent cylinder, a reagent rotating device for rotating the reagent cylinder, and a reagent feeding device for feeding reagents in the reagent boxes onto the detection mechanism; the detection mechanism comprises a reaction disc rotationally connected with the frame, a plurality of reaction cups arranged on the reaction disc, a reaction rotating device for rotating the reaction disc, a stirring device for stirring samples in the reaction cups, an optical detection device for detecting the samples stirred by the stirring device and a cleaning device for cleaning the reaction cups; the rotating device, the stirring device, the optical detection device and the cleaning device are all arranged on the frame.
The actual use effect of the sample transmission mechanism in the actual use process of the biochemical analyzer of the technical scheme is not ideal, and especially the structural mode and the operation mode of the sample transmission mechanism cannot be adapted to full automation, and seamless connection matching sampling cannot be carried out with other instruments.
Disclosure of Invention
The invention aims to provide a full-automatic biochemical analyzer, which selectively transmits a sample to be detected to a preset sampling position, expands the matching degree of a sample injection module and other detection platforms, and improves the independence of the sample injection module.
In order to solve the technical problems, the invention adopts the technical scheme that the full-automatic biochemical analyzer is characterized by comprising a sample injection module, a reagent injection module, a reaction and detection module, a stirring and mixing module and a reaction cup cleaning module; the sample filling module, the reagent filling module, the reaction and detection module, the stirring and mixing module and the reaction cup cleaning module are all arranged on the base; the sample injection module transmits a sample to be detected to a preset sampling position, and the sample to be detected is moved to the reaction and detection module for detection through the sample filling module; the reagent filling module is used for filling a reagent into a sample to be detected, the stirring and mixing module is used for stirring and mixing the sample to be detected and the reagent uniformly, and the reaction cup cleaning module is used for cleaning a reaction cup;
The sample feeding modules comprise a plurality of sample racks, and two adjacent sample feeding modules are spliced together, so that the sample racks are transmitted to positions farther than the preset sampling positions through the spliced sample feeding modules; the full-automatic biochemical analyzer is provided with an operation screen.
In the above technical solution, the sample injection module transmits the sample to be detected to a preset sampling position, that is, the sample injection module transmits the sample to be detected to the preset sampling position according to the requirement of the sample to be detected, so that the operation mode of the sample injection module is relatively independent, the sampling position is not only the full-automatic biochemical analyzer of the invention, but also other detection instruments are available, that is, the sample injection module can adapt to other detection instruments, and the sample injection module can perform sample detection in a pipelining manner, for example, the sample can be matched with other detection instrument platforms for sampling (performing seamless connection matching sampling with other instruments) after being transmitted in the full-automatic biochemical analyzer of the invention, so as to perform detection such as chemiluminescence and fluorescence immunoassay technology platform, if the sample does not need to be detected by a certain instrument, the sample is transmitted by the sample injection module, and the sample injection module is skipped to directly reach the preset sampling position of the instrument to be detected, so as to realize full-automatic sample injection; it should be emphasized that the sample injection module in the existing other analysis instruments does not carry out the matching detection on the sample injection module and other detection instrument platforms, but the sample injection module is a preset sampling position when the sample to be detected is transmitted, the sample to be detected is transmitted to the instrument to be detected, specifically, the preset transmission of the sampling position of the detection instrument is carried out according to the detection requirement of the sample to be detected, the sample to be detected can be selectively transmitted to different sampling positions, the matching degree of the sample injection module and other detection platforms is enlarged, and the independence of the sample injection module is improved.
The sample to be detected is more conveniently transmitted by combining and splicing the sample injection modules, and the instrument is faster to assemble; sampling locations may be selected as desired, as may more detection platforms or instruments.
Preferably, the sample injection module and the base are mutually independent, so that the adaptation degree of the sample injection module is enlarged; the sample injection module comprises a sample rack, and at least one sample tube is placed on the sample rack; the sample rack is driven by the sample inlet and outlet conveying component to carry out conveying action; the sample injection module further comprises a sample injection assembly and a sampling hand pulling assembly, wherein the sample injection assembly performs sample injection action on the sample rack, and the sampling hand pulling assembly performs pulling action on the sample rack.
The sample injection module and the base are mutually independent, so that the operation mode of the sample injection module is relatively independent in structure, and the sample to be detected is more convenient to convey to a sampling position; the sample injection module can be better matched with other instruments in structure, and especially can be better connected when a sample to be detected is conveyed.
Preferably, the sample inlet and outlet conveying assembly comprises a sample inlet and outlet conveying belt, and the sample rack is placed on the sample inlet and outlet conveying belt; the sample feeding and discharging conveying belt is driven by a sample feeding and discharging conveying motor, the sample feeding and discharging conveying motor drives a sample feeding and discharging conveying driving wheel to rotate, and the sample feeding and discharging conveying driving wheel drives a sample feeding and discharging synchronous wheel I, a sample feeding and discharging synchronous wheel II and a sample feeding and discharging synchronous wheel III to rotate through the sample feeding and discharging conveying belt.
The sample rack is put on a sample in-out conveying belt and is conveyed along with the sample in-out conveying belt; the first sample inlet and outlet synchronizing wheel, the second sample inlet and outlet synchronizing wheel and the third sample inlet and outlet synchronizing wheel play roles in improving the space position and tensioning and supporting the sample inlet and outlet conveying belt.
Preferably, the sample injection assembly comprises a sample injection track-changing pushing hand assembly and a sample injection shifting hand assembly, wherein the sample injection track-changing pushing hand assembly is provided with a sample injection track-changing pushing hand, and the sample injection shifting hand assembly is provided with a sample injection shifting hand; the sample feeding track-changing pushing hand pushes a sample rack on the sample feeding and discharging conveying belt to the moving range of the sample feeding pulling hand, and the sample rack is pulled to the moving range of the sample feeding pulling hand assembly by the sample feeding pulling hand.
The sample feeding rail-changing pushing hand pushes the sample rack away from the sample feeding and discharging conveyor belt, and then the sample feeding operation is carried out by the sample feeding pushing hand.
Preferably, the sample injection track-changing pusher is connected with a sample injection track-changing pusher slide block, and the sample injection track-changing pusher slide block moves along a sample injection track-changing pusher slide rail; the sample injection track-changing pusher slide block is connected with the sample injection track-changing pusher belt through a sample injection track-changing pusher belt connecting piece; the sample injection track-changing pusher motor drives the sample injection track-changing pusher driving wheel to rotate, and the sample injection track-changing pusher driving wheel drives the sample injection track-changing pusher driven wheel to rotate through the sample injection track-changing pusher belt.
The sample introduction rail-changing pushing hand belt rotates to drive the sample introduction rail-changing pushing hand to move, and the sample introduction rail-changing pushing hand can push the sample rack into the movable range of the sample introduction pulling hand.
Preferably, the sample introduction pulling hand is connected with a sample introduction pulling hand sliding block, and the sample introduction pulling hand sliding block moves along a sample introduction pulling hand sliding rail; the sample introduction hand pulling sliding block is connected with a sample introduction hand pulling belt through a sample introduction hand pulling belt connecting piece; the sample introduction hand-pulling machine drives the sample introduction hand-pulling driving wheel to rotate, and the sample introduction hand-pulling driving wheel drives the sample introduction hand-pulling driven wheel to rotate through the sample introduction hand-pulling belt.
The sample introduction handle belt rotates to drive the sample introduction handle to move, and the sample introduction handle can stir the sample rack to the movable range of the sample introduction handle assembly.
Preferably, the sample injection module further comprises a sample injection blocking component, and a sample injection blocking piece in the sample injection blocking component is used for blocking the sample rack; the motor shaft of the sample injection blocking motor is sequentially connected with the sample injection blocking baffle plate and the sample injection blocking piece, one end of the sample injection blocking baffle plate extends out of the sample injection blocking baffle plate I, and the other end extends out of the sample injection blocking baffle plate II; a first sample injection blocking optical coupler and a second sample injection blocking optical coupler are respectively arranged above and below the sample injection blocking baffle; when the sample blocking optical coupler II senses the sample blocking baffle II, the sample blocking piece blocks the sample rack; when the sample blocking optocoupler senses that the sample blocking baffle is at one time, the sample blocking piece releases the sample rack, so that the sample rack is driven by the sample in-out conveying assembly to perform conveying action.
When the sample rack is required to be blocked, the sample blocking piece is controlled to rotate until the sample blocking optical coupler II senses that the sample blocking piece II stops moving, and the sample blocking piece blocks the sample rack to stop moving; when the sample rack is not required to be blocked, the sample blocking piece moves reversely until the sample blocking optocoupler senses that the sample blocking piece stops moving once, and the sample rack can continue to move along the sample inlet and outlet conveying belt.
Preferably, the sample injection module further comprises a sample outlet blocking component, and a sample outlet blocking piece in the sample outlet blocking component is used for blocking the sample rack; the motor shaft of the sample discharging blocking motor is sequentially connected with the sample discharging blocking baffle plate and the sample discharging blocking piece, one end of the sample discharging blocking baffle plate extends out of the first sample discharging blocking baffle plate, and the other end of the sample discharging blocking baffle plate extends out of the second sample discharging blocking baffle plate; a first sample-discharging blocking optical coupler and a second sample-discharging blocking optical coupler are respectively arranged above and below the sample-discharging blocking baffle; when the second sample blocking optical coupler senses the second sample blocking baffle plate, the second sample blocking baffle plate blocks the sample frame; when the sample outputting blocking optocoupler senses that the sample outputting blocking baffle is one, the sample outputting blocking piece releases the sample frame, so that the sample frame is driven by the sample outputting and inputting conveying assembly to carry out conveying action.
When the sample rack is subjected to sample discharging, the blocking and releasing motion principle of the sample discharging blocking piece on the sample rack is the same as that of the sample feeding blocking piece.
Preferably, the sampling hand assembly comprises a sampling hand, the sampling hand comprises a first sampling hand and a second sampling hand, and the first sampling hand and the second sampling hand are respectively connected to two ends of the sampling hand; the sampling handle is connected with a sampling handle sliding block, and the sampling handle sliding block moves along a sampling handle sliding rail; the sampling handle sliding block is connected with a sampling handle belt through a sampling handle belt connecting piece, the sampling handle driving wheel is driven to rotate by the sampling handle lifting machine, and the sampling handle driving wheel drives the sampling handle driven wheel to rotate through the sampling handle belt.
Preferably, the sampling hand-pulling belt connecting piece is provided with a first sampling hand-pulling blocking piece and a second sampling hand-pulling blocking piece; the first sampling hand contacts the sample frame to push the sample frame to move towards a sampling position, when the first sampling hand optical coupler senses the first sampling hand blocking piece, the sampling hand moves reversely, when the second sampling hand optical coupler senses the second sampling hand blocking piece, the second sampling hand contacts the sample frame to continuously stir the sample frame to move towards an original movement direction, and after sample sampling is completed, the second sampling hand stirs the sample frame to enter the movement range of the sample discharging hand assembly.
The sampling hand-pulling belt rotates to drive the sampling hand-pulling belt to move; and a sample rack entering the movable range of the sample discharging handle assembly is driven into the sample feeding and discharging conveyor belt by the sample discharging handle assembly, and then the sampled sample rack is removed.
Preferably, the sample discharging handle assembly is provided with a sample discharging handle, the sample discharging handle is connected with a sample discharging handle sliding block, and the sample discharging handle sliding block moves along a sample discharging handle sliding rail; the sample discharging handle sliding block is connected with a sample discharging handle belt through a sample discharging handle belt connecting piece; the sample discharging hand-pulling machine drives the sample discharging hand-pulling driving wheel to rotate, and the sample discharging hand-pulling driving wheel drives the sample discharging hand-pulling driven wheel to rotate through the sample discharging hand-pulling belt.
The sample discharging handle belt rotates to drive the sample discharging handle to move.
Preferably, the sample injection module is provided with an emergency detection assembly, and the emergency detection assembly comprises an emergency detection position for placing a sample; the emergency detection assembly further comprises an emergency detection motor, the emergency detection motor drives the emergency detection screw rod to rotate, and an emergency detection screw rod nut on the emergency detection screw rod is connected with an emergency detection screw rod nut connecting piece; the emergency detection screw nut connecting piece is connected with the emergency detection position, and the emergency detection screw nut connecting piece moves along an emergency detection sliding rail through an emergency detection sliding block.
When the emergency detection sample exists, the emergency detection sample is placed in an emergency detection position, the emergency detection position moves to a sample needle sampling position, and after sampling, the emergency detection sample is detected by the instrument.
Preferably, the sample needle of the sample filling module quantitatively moves the sample to be detected into a reaction cup in the reaction and detection module, and the sample needle after moving the sample is cleaned in a sample needle cleaning station; the sample needle is arranged on a sample needle swing arm which is connected with a sample needle spline shaft; the sample needle horizontal movement assembly realizes the horizontal rotation movement of the sample needle by driving the sample needle spline shaft to rotate, and the sample needle up-and-down movement assembly realizes the up-and-down movement of the sample needle by driving the sample needle spline shaft to move up and down.
The sample needle can move up and down and horizontally in a rotating mode, and the sample needle quantitatively moves to-be-detected samples more automatically.
Preferably, a sample needle protection component is arranged on the sample needle swing arm, the sample needle is fixedly connected with the sample needle swing arm through a sample needle seat, a spring bolt of the sample needle protection component is fixedly connected with the sample needle seat, and a spring is sleeved on the spring bolt.
The sample needle shield assembly prevents accidental bottoming of the sample needle from damaging the needle head.
Preferably, the top end of the sample needle is connected with a sample needle liquid path interface and is used for connecting with a cleaning liquid to clean the inner wall of the sample needle; sample needle separation blade is provided with on the sample needle connecting piece that is connected with sample needle file, sample needle separation blade with sample needle response opto-coupler on the sample needle swing arm is responded to the unexpected bottoming condition of sample needle to give instrument CPU with the response signal feedback, then control sample needle up-and-down motion subassembly, correct the malfunction of sample needle up-and-down motion subassembly.
The sample needle separation blade is matched with the sample needle sensing optocoupler to sense the accidental bottoming condition of the sample needle, and the sample needle up-and-down movement assembly is timely blocked to continuously drive the sample needle to move downwards to damage the needle head.
Preferably, the sample needle cleaning station comprises a sample needle cleaning liquid inlet which is communicated with the sample needle cleaning cavity; the side face of the sample needle cleaning cavity is provided with a cleaning liquid protection block, and waste liquid after the sample needle is cleaned is discharged through a cleaning liquid outlet.
The cleaning liquid protection block plays a role in reducing splashing of the cleaning liquid; the cleaning liquid enters from a cleaning liquid inlet of the sample needle, the outer wall of the sample needle is washed, and the waste liquid after washing passes through a cleaning liquid drain port; the cleaning of the inside of the sample needle is performed by the cleaning liquid entering the sample needle.
Preferably, the sample needle horizontal movement assembly comprises a sample needle horizontal movement motor, the sample needle horizontal movement motor drives a sample needle horizontal movement driving wheel to rotate, and the sample needle horizontal movement driving wheel drives a sample needle horizontal movement driven wheel to rotate through a sample needle horizontal movement belt; sample needle code wheel is arranged below the sample needle horizontal movement driven wheel, the sample needle spline shaft is driven to rotate by the sample needle horizontal movement driven wheel, and the sample needle code wheel synchronously rotates along with the sample needle.
Preferably, a sample needle limit groove is formed in the sample needle code disc, and the sample needle limit groove is matched with a sample needle limit optocoupler to perform identification control on sample to be detected, sample to be detected and cleaning behaviors of the sample needle.
Preferably, the sample needle up-and-down motion assembly comprises a sample needle up-and-down motion motor, the sample needle up-and-down motion motor drives a sample needle up-and-down motion driving wheel to rotate, and the sample needle up-and-down motion driving wheel drives a sample needle up-and-down motion driven wheel to rotate through a sample needle up-and-down motion belt; the sample needle spline shaft is connected with the sample needle up-and-down motion sliding block, and the sample needle up-and-down motion belt drives the sample needle up-and-down motion sliding block to move along the sample needle up-and-down motion sliding rail.
Preferably, the reagent needle of the reagent filling module moves the reaction reagent into a reaction cup located in the reaction and detection module; the reagent needle is arranged on a reagent needle swing arm which is connected with a reagent needle spline shaft; the reagent needle left-right movement assembly realizes the left-right movement of the reagent needle by driving the reagent needle spline shaft to rotate, and the reagent needle up-down movement assembly realizes the up-down movement of the reagent needle by driving the reagent needle spline shaft to move up and down.
The reagent needle can move up and down and left and right, the reaction reagent is sucked and transferred to a reaction cup in the reaction disk to react with the sample, and the reagent needle is more automatic in transferring the reaction reagent.
Preferably, the reagent needle left-right movement assembly comprises a reagent needle left-right movement motor, the reagent needle left-right movement motor drives a reagent needle left-right movement driving wheel to rotate, the reagent needle left-right movement driving wheel drives a reagent needle left-right movement driven wheel to rotate through a reagent needle left-right movement belt, and the reagent needle left-right movement driven wheel drives the reagent needle spline shaft to rotate.
Preferably, the reagent needle up-and-down motion assembly comprises a reagent needle up-and-down motion motor, the reagent needle up-and-down motion motor drives a reagent needle up-and-down motion driving wheel to rotate, and the reagent needle up-and-down motion driving wheel drives a reagent needle up-and-down motion driven wheel to rotate through a reagent needle up-and-down motion belt; the reagent needle spline shaft is connected with the reagent needle up-and-down motion sliding block, and the reagent needle up-and-down motion belt drives the reagent needle up-and-down motion sliding block to move along the reagent needle up-and-down motion sliding rail through the reagent needle up-and-down motion belt connecting piece.
Preferably, the reagent delivered by the reagent needle is contained in a reagent disk, the reagent disk comprises an inner ring and an outer ring, the outer ring is used for placing the outer ring reagent R1, and the inner ring is used for placing the inner ring reagent R2; the inner and outer rings are used for containing reagents in a classified way, the confusion is not easy to occur.
Preferably, the reagent disk is driven to rotate by a reagent disk rotating assembly, the reagent disk rotating assembly comprises a reagent disk rotating motor, the reagent disk rotating motor drives a reagent disk rotating driving wheel to rotate, and the reagent disk rotating driving wheel drives a reagent disk rotating driven wheel to rotate through a reagent disk rotating belt; the reagent disk drives the reagent disk rotating shaft to rotate through the reagent disk rotating driven wheel.
The reagent disk rotates to facilitate the reagent needle to suck the reagents R1 and R2 one by one from the reagent disk containing the reaction reagent, and the reaction reagent is transferred into the reaction disk.
Preferably, the lower part of the reagent disk rotating shaft is connected with a reagent disk code disk, and the reagent disk code disk is provided with a reagent disk limiting groove and a reagent disk limiting piece; the reagent disk limiting groove is matched with the first reagent disk limiting optical coupler, and the reagent disk limiting piece is matched with the second reagent disk limiting optical coupler.
The reagent disk limiting grooves and the reagent disk limiting sheets (1 for identifying the number of rotation turns) are correspondingly provided with optocouplers, and the reagent positions (each reagent position corresponds to one limiting groove) on the reagent disk and the number of rotation turns of the reagent disk are respectively identified.
Preferably, a code scanning window is arranged on one side of the reagent disk, and the reagent bottle code scanning device scans codes of reagent bottles positioned at the position of the code scanning window; the Peltier and the reagent tray cooling fin are arranged below the reagent tray, and the exhaust fan is arranged at the lower part of the reagent tray cooling fin.
The reagent bottle code scanner can scan codes of reagent bottles in the reagent disk and input relevant information of reagents, namely production batch numbers, validity periods, names and the like; the peltier and the cooling fin of the reagent tray and the two sets of refrigeration components enable the working environment of the peltier to dissipate heat in time, ensure normal refrigeration work of the peltier, and enable the reagent to keep a low-temperature state and keep reactivity.
Preferably, the stirring and mixing module comprises a stirring paddle, and the stirring paddle is driven by a stirring motor to perform stirring action; the stirring paddle is connected with a stirring paddle spline shaft, the stirring paddle left-right movement assembly realizes the left-right movement of the stirring paddle by driving the stirring paddle spline shaft to rotate, and the stirring paddle up-down movement assembly realizes the up-down movement of the stirring paddle by driving the stirring paddle spline shaft to move up and down.
The stirring and mixing module enables the reaction sample in the reaction tray and the reagent to be stirred and mixed uniformly, so that the reaction is fully carried out.
Preferably, the stirring paddle left-right movement assembly comprises a stirring paddle left-right movement motor, the stirring paddle left-right movement motor drives a stirring paddle left-right movement driving wheel to rotate, the stirring paddle left-right movement driving wheel drives a stirring paddle left-right movement driven wheel to rotate through a stirring paddle left-right movement belt, and the stirring paddle left-right movement driven wheel drives a stirring paddle spline shaft to rotate.
Preferably, the stirring paddle up-and-down motion assembly comprises a stirring paddle up-and-down motion motor, the stirring paddle up-and-down motion motor drives a stirring paddle up-and-down motion driving wheel to rotate, and the stirring paddle up-and-down motion driving wheel drives a stirring paddle up-and-down motion driven wheel to rotate through a stirring paddle up-and-down motion belt; the stirring paddle spline shaft is connected with a stirring paddle up-and-down motion sliding block, and the stirring paddle up-and-down motion belt drives the stirring paddle up-and-down motion sliding block to move along a stirring paddle up-and-down motion sliding rail through a stirring paddle up-and-down motion belt connecting piece.
Preferably, the stirring and mixing module is further provided with a stirring paddle code disc, and the stirring paddle code disc is provided with a stirring paddle code disc limiting groove; the stirring paddle code wheel limiting groove is matched with the stirring paddle code wheel limiting optocoupler and is used for identifying stirring of the stirring paddle and a cleaning position after stirring.
Preferably, the stirring paddle is connected with the stirring motor through a stirring rod; the stirring and mixing module is also provided with a stirring paddle cleaning station for cleaning the stirring paddles; the stirring paddle cleaning station comprises a stirring paddle cleaning station inlet, and the stirring paddle cleaning station inlet is communicated with a stirring paddle cleaning liquid inlet through a stirring paddle cleaning cavity; the end face of the stirring paddle cleaning liquid inlet is lower than the end face of the stirring paddle cleaning station, and splashed liquid flows out through a liquid outlet of the stirring paddle cleaning station; the stirring paddle cleaning cavity is communicated with the stirring paddle cleaning station liquid outlet through the stirring paddle cleaning cavity liquid outlet.
The end face of the stirring paddle cleaning liquid inlet is lower than the end face of the stirring paddle cleaning station, so that when the stirring paddle is sprayed and washed, splashed liquid still falls into the stirring paddle cleaning station and flows out through the liquid outlet of the stirring paddle cleaning station, and the non-splashed cleaning liquid is discharged from the liquid outlet of the stirring paddle cleaning station.
Preferably, the reaction and detection module comprises a reaction disc assembly, wherein the reaction disc assembly is provided with a reaction disc, and a plurality of reaction cup positions are arranged in the reaction disc and are used for placing reaction cups; the reaction disk is driven to rotate by the reaction disk movement assembly through the reaction disk rotating shaft, and the optical signals of the detection light source after the emitted light passes through the reaction cup are received by the spectrometer box, so that the detection analysis is carried out on the optical signals.
The reaction disk rotates, so that the light emitted by the light source can be conveniently detected to irradiate the rotating reaction cup; furthermore, the reaction disk is rotated, so that samples and reaction reagents can be conveniently added into the reaction cup in the reaction disk in sequence.
Preferably, the reaction plate movement assembly comprises a reaction plate movement motor, the reaction plate movement motor drives a reaction plate movement driving wheel to rotate, the reaction plate movement driving wheel drives a reaction plate movement driven wheel to rotate through a reaction plate movement belt, and the reaction plate movement driven wheel drives a reaction plate rotating shaft to rotate through the reaction plate movement driven wheel.
Preferably, a reaction disc code disc is arranged in the reaction and detection module, a reaction disc code disc limiting groove is arranged on each reaction cup position corresponding to the reaction disc code disc, and a reaction disc code disc limiting optocoupler is matched with the reaction disc code disc limiting groove to identify each detection position; the reaction disc coded disc is further provided with a reaction disc coded disc limiting baffle plate, and the reaction disc coded disc limiting optocoupler II is matched with the reaction disc coded disc limiting baffle plate to identify the rotation number of the reaction disc.
Preferably, a heating film is arranged on the bottom surface of each reaction cup position of the reaction disk, and meanwhile, a heat insulation layer is also arranged on the reaction disk; a temperature sensor is arranged below the reaction disc and used for monitoring the temperature; the side surface of the reaction disk is provided with a flow guiding structure for guiding the leaked liquid in the reaction disk.
When in reaction, the heating film can be started to incubate the reaction cup at constant temperature according to the reaction condition; the flow guiding structure has the function of guiding flow if liquid leakage exists in the reaction disk, so that the internal structure of the reaction disk is prevented from being corroded.
Preferably, a radiating fin is arranged at the lower part of the detection light source; the spectrometer box is supported by a spectrometer box support, and the detection light source, the radiating fins, the spectrometer box and the spectrometer box support form a spectrometer box assembly.
The lower part of the detection light source is provided with a cooling fin, ensuring the proper detection environment temperature.
Preferably, the reaction cup cleaning module comprises a cleaning needle assembly, wherein the cleaning needle assembly is provided with at least one cleaning needle group and a wiping head, and the cleaning needle group comprises a liquid inlet needle and a liquid outlet needle; the cleaning needle assembly is connected with the cleaning needle movement supporting rod, and the cleaning needle up-and-down movement assembly drives the cleaning needle assembly to move up and down through the cleaning needle movement supporting rod.
The reaction cup is a non-disposable consumable material, can be repeatedly used after being cleaned, and is cleaned by utilizing the up-and-down motion of the cleaning needle; the cleaning needle group cleans the reaction cup, and the wiping head wipes the reaction cup.
Preferably, the cleaning needle up-and-down motion assembly comprises a cleaning needle up-and-down motion motor, the cleaning needle up-and-down motion motor drives a motor shaft connecting rod to rotate, and a connecting rod sliding block is connected to the motor shaft connecting rod; the connecting rod sliding block moves left and right in a sliding groove of the sliding groove block to drive the cleaning needle movement supporting rod to move up and down; the cleaning needle movement support rod is connected with the sliding groove block, and a cleaning needle movement spring is arranged below the sliding groove block.
The cleaning needle moving spring is arranged, so that the needle damage caused by the falling of the cleaning needle is prevented when the machine is out of control.
Preferably, the wiping head is provided with a wiping head groove, and the wiping head groove is clamped with the limit bolt, so that the wiping head is connected with the wiping head rod; the bottom surface of the wiping head is provided with a groove pipeline.
When the wiping head is pressed down into the reaction cup, residual liquid in the reaction cup enters the groove pipeline, the reaction cup is wiped clean, and the reaction cup can be repeatedly cleaned before the next detection.
Preferably, the cleaning needle assembly further comprises a cleaning needle assembly bracket, and the cleaning needle group is connected below the cleaning needle assembly bracket; the cleaning needle assembly bracket is provided with a cleaning needle spring seat, a cleaning needle spring is arranged on the cleaning needle spring seat, and a cleaning needle fixing head is arranged above the cleaning needle spring; the cleaning needle group, the cleaning needle spring seat and the cleaning needle fixing head are assembled to form an integrated cleaning needle group, the integrated cleaning needle group is in non-fixed connection with the cleaning needle component support, and the cleaning needle spring is sleeved on the integrated cleaning needle group.
The cleaning needle spring can protect the needle and prevent the needle head from being accidentally damaged due to excessive descent.
Preferably, the reaction cup cleaning module and the stirring and mixing module are arranged around the reaction and detection module; the sample filling module is arranged on the side surface of the sample injection module, and the sample filling module and the reagent filling module are both positioned on the side surface of the reaction and detection module; the method has the advantages that the reaction and detection modules are used as the center to carry out reasonable module layout, the coordination time among the modules is fully saved, and the rapid analysis and detection are realized.
Preferably, the full-automatic biochemical analyzer further comprises a sample code scanning device, wherein the sample code scanning device is positioned on the side surface of the sample filling module; the sample code scanning device comprises a sample tube rotating assembly and a code scanning assembly; the sample tube rotating assembly is provided with a rubber ring, and the rubber ring rubs the sample tube to enable the sample tube to rotate; the code scanner scans the sample tube at different angles to finish the code scanning of the sample tube and input sample information.
Preferably, the code scanning assembly further comprises a code scanner bracket, and the code scanner is arranged on the code scanner bracket; the sample tube rotating assembly comprises a sample tube rotating motor, the rubber ring is sleeved on a pulley, and the pulley is arranged on a motor shaft of the sample tube rotating motor.
The sample code scanning device is arranged on the base and is divided into a sample tube rotating assembly and a code scanning assembly, and is responsible for automatically scanning codes of bar codes on the sample tube and inputting sample information; the motor shaft is provided with a pulley, the rubber ring is sleeved on the pulley, the sample tube rotating motor is started to drive the rubber ring to rotate, the rubber ring rubs the sample tube to enable the sample tube to rotate, and the code scanner scans the sample tube at different angles to finish code scanning of the sample tube.
Drawings
The following is a further detailed description of embodiments of the invention with reference to the accompanying drawings:
FIG. 1 is a schematic diagram showing the overall structure of a fully automatic biochemical analyzer according to the present invention;
FIG. 2 is a schematic top view of the fully automated biochemical analyzer of FIG. 1;
FIG. 3 is a schematic view of the fully automatic biochemical analyzer of FIG. 1 with the sample module removed;
FIG. 4 is a schematic top view of the structure of FIG. 3;
FIG. 5 is a schematic diagram of a sample injection module in the fully automatic biochemical analyzer of FIG. 1;
FIG. 6 is a schematic diagram of the sample injection module of FIG. 5 with the emergency detection assembly and the sample flow manifold removed;
FIG. 7 is a second schematic diagram of the sample injection module of FIG. 5 with the emergency detection assembly and the sample flow manifold removed;
FIG. 8 is a schematic diagram of the structure of the sample injection assembly;
FIG. 9 is a schematic diagram of the sample assembly (with the sample assembly housing removed);
FIG. 10 is a schematic structural view of a sample hand assembly;
FIG. 11 is a schematic view of the construction of the sample hand assembly;
FIG. 12 is a schematic structural view of an injection blocking assembly;
FIG. 13 is a schematic view of the construction of the sample barrier assembly;
FIG. 14 is a schematic diagram of an emergency detection module;
FIG. 15 is a schematic view of the structure of the sample filling module;
FIG. 16 is a schematic structural view of a sample needle swing arm in a sample filling module;
FIG. 17 is a schematic view of the structure of a sample needle in the sample filling module;
FIG. 18 is a schematic top view of a sample needle code wheel in a sample filling module;
FIG. 19 is a schematic cross-sectional view of a sample needle cleaning station in the sample filling module;
FIG. 20 is a perspective view of a sample needle cleaning station in the sample filling module;
FIG. 21 is a schematic view of the structure of a reagent dispensing module (without a reagent tray);
FIG. 22 is a schematic overall construction of a reagent filling module;
FIG. 23 is a schematic illustration of a reagent disk assembly in a reagent dispensing module;
FIG. 24 is a schematic diagram of a reagent tray refrigeration assembly in a reagent filling module;
FIG. 25 is a schematic view of a reagent disk rotating assembly in a reagent filling module;
FIG. 26 is a schematic view of the partially enlarged construction of FIG. 25;
fig. 27 is a schematic structural view of a stirring and mixing module;
fig. 28 is a schematic diagram II of the structure of the stirring and mixing module;
Fig. 29 is a schematic view of a stirring paddle structure in the stirring and mixing module;
FIG. 30 is a schematic diagram of a paddle wash station in a mixing module;
FIG. 31 is a schematic diagram II of a paddle wash station in a mixing module;
FIG. 32 is a schematic diagram III of a paddle wash station configuration in a mixing module;
FIG. 33 is a schematic diagram of a reaction and detection module;
FIG. 34 is a schematic view of the structure of a cuvette in the reaction and detection module;
FIG. 35 is a schematic view of a partial enlarged structure of the reaction and detection module of FIG. 33;
FIG. 36 is a schematic diagram showing a second configuration of the reaction and detection module;
FIG. 37 is a schematic cross-sectional view of a reaction plate in the reaction and detection module;
FIG. 38 is a schematic view of the construction of a reaction plate movement assembly in the reaction and detection module;
FIG. 39 is a schematic diagram of the structure of a spectrometer cassette assembly in a reaction and detection module;
FIG. 40 is a schematic view of a cuvette cleaning module;
FIG. 41 is a schematic diagram II of a cuvette cleaning module;
FIG. 42 is a schematic view of a partially enlarged construction of a cleaning needle set in a cuvette cleaning module;
FIG. 43 is a schematic view of the structure of the wiper head in the cuvette cleaning module;
FIG. 44 is a schematic view of the structure of a cleaning needle assembly in a cuvette cleaning module;
FIG. 45 is a schematic diagram of a sample code scanner;
FIG. 46 is a schematic diagram of a sample code scanner;
FIG. 47 is a schematic view of a partial enlarged structure of the sample code scanner of FIG. 45;
FIG. 48 is a schematic diagram of a cuvette cleaning module performing a cleaning operation;
FIG. 49 is a test flow chart of the fully automated biochemical analyzer of the present invention;
wherein: 1-sample injection module, 101-sample rack, 102-sample tube, 103-sample feeding and discharging transmission component, 10301-sample feeding and discharging transmission belt, 10302-sample feeding and discharging transmission motor, 10303-sample feeding and discharging transmission driving wheel, 10304-sample feeding and discharging synchronous wheel I, 10305-sample feeding and discharging synchronous wheel II, 10306-sample feeding and discharging synchronous wheel III, 104-sample hand pulling component, 10401-sample hand pulling, 10402-sample hand pulling I, 10403-sample hand pulling II, 10404-sample hand pulling arm, 10405-sample hand pulling sliding block, 10406-sample hand pulling sliding rail, 10407-sampling hand belt connector, 10408-sampling hand belt, 10409-sampling hand motor, 104010-sampling hand driving wheel, 104011-sampling hand driven wheel, 104012-sampling hand baffle one, 104013-sampling hand baffle two, 104014-sampling hand optical coupler one, 104015-sampling hand optical coupler two, 105-sample injection assembly, 10501-sample injection assembly housing, 106-sample injection track change pusher assembly, 10601-sample injection track change pusher, 10602-sample injection track change pusher slide, 10603-sample injection track change pusher slide rail, 10604-sample introduction track-changing pusher belt connecting piece, 10605-sample introduction track-changing pusher belt, 10606-sample introduction track-changing pusher motor, 10607-sample introduction track-changing pusher driving wheel, 10608-sample introduction track-changing pusher driven wheel, 107-sample introduction pusher component, 10701-sample introduction pusher; 10702-sample introduction shifting slide block, 10703-sample introduction shifting slide rail, 10704-sample introduction shifting belt connecting piece, 10705-sample introduction shifting belt, 10706-sample introduction shifting motor, 10707-sample introduction shifting driving wheel, 10708-sample introduction shifting driven wheel, 108-sample introduction blocking component, 10801-sample introduction blocking piece, 10802-sample introduction blocking motor, 10803-sample introduction blocking piece, 10804-sample introduction blocking piece I, 10805-sample introduction blocking piece II, 10806-sample introduction blocking optical coupler I, 10807-sample introduction blocking optical coupler II, 109-sample-discharging blocking component, 10901-sample-discharging blocking piece, 10902-sample-discharging blocking motor, 10903-sample-discharging blocking baffle, 10904-sample-discharging blocking baffle I, 10905-sample-discharging blocking baffle II, 10906-sample-discharging blocking optical coupler I, 10907-sample-discharging blocking optical coupler II, 1010-sample-discharging handle component, 101001-sample-discharging handle, 101002-sample-discharging handle slide block, 101003-sample-discharging handle slide rail, 101004-sample-discharging handle belt connector, 101005-sample-discharging handle belt, 101006-sample-discharging handle motor, 101007-a sample discharge shifting hand driving wheel, 101008-a sample discharge shifting hand driven wheel, 1011-an emergency detection assembly, 101101-an emergency detection position, 101102-an emergency detection motor, 101103-an emergency detection screw rod, 101104-an emergency detection screw rod nut, 101105-an emergency detection screw rod nut connector, 101106-an emergency detection sliding block, 101107-an emergency detection sliding rail and 1012-a sample circulation supporting plate; 2-sample filling module, 201-sample needle, 20101-sample needle head, 202-sample needle cleaning station, 20201-sample needle cleaning fluid inlet, 20202-sample needle cleaning cavity, 20203-cleaning fluid protection block, 20204-cleaning fluid drain, 203-sample needle swing arm, 204-sample needle spline shaft, 205-sample needle horizontal movement assembly, 20501-sample needle horizontal movement motor, 20502-sample needle horizontal movement driving wheel, 20503-sample needle horizontal movement belt, 20504-sample needle horizontal movement driven wheel, 206-sample needle up-down movement assembly, 20601-sample needle up-down motion motor, 20602-sample needle up-down motion driving wheel, 20603-sample needle up-down motion belt, 20604-sample needle up-down motion driven wheel, 20605-sample needle up-down motion slider, 20606-sample needle up-down motion slide rail, 207-sample needle protection component, 20701-latch, 20702-spring, 208-sample needle seat, 209-sample needle liquid path interface, 2010-sample needle connector, 2011-sample needle baffle, 2012-sample needle sensing optocoupler, 2013-sample needle code wheel, 201301-sample needle limit groove, 201302-sample needle limit optocoupler; A 3-reagent filling module, 301-reagent needle, 302-reagent needle swing arm, 303-reagent needle spline shaft, 304-reagent needle left and right movement assembly, 30401-reagent needle left and right movement motor, 30402-reagent needle left and right movement driving wheel, 30403-reagent needle left and right movement belt, 30404-reagent needle left and right movement driven wheel, 305-reagent needle up and down movement assembly, 30501-reagent needle up and down movement motor, 30502-reagent needle up and down movement driving wheel, 30503-reagent needle up and down movement belt, 30504-reagent needle up and down movement driven wheel, 30505-reagent needle up and down movement sliding block, 30506-reagent needle up-and-down motion belt connecting piece, 30307-reagent needle up-and-down motion slide rail, 306-reagent disk, 30401-outer ring, 30602-inner ring, 307-reagent disk rotation assembly, 30701-reagent disk rotation motor, 30702-reagent disk rotation driving wheel, 30703-reagent disk rotation belt, 30704-reagent disk rotation driven wheel, 30705-reagent disk rotation shaft, 308-reagent disk code disk, 30801-reagent disk limit groove, 30802-reagent disk limit piece, 30803-reagent disk limit optical coupler one, 30804-reagent disk limit optical coupler two, 309-code scanning window, 3010-reagent bottle code scanner, 3011-Peltier, 3012-reagent tray cooling fin, 3013-exhaust fan; 4-stirring and mixing modules, 401-stirring paddles, 402-stirring motors, 403-stirring paddle spline shafts, 404-stirring paddle left-right movement assemblies, 40401-stirring paddle left-right movement motors, 40402-stirring paddle left-right movement driving wheels, 40403-stirring paddle left-right movement belts, 40404-stirring paddle left-right movement driven wheels, 405-stirring paddle up-down movement assemblies, 40501-stirring paddle up-down movement motors, 40502-stirring paddle up-down movement driving wheels, 40503-stirring paddle up-down movement belts, 40504-stirring paddle up-down movement driven wheels, 40505-stirring paddle up-down movement sliding blocks, 40506-a stirring paddle up-down motion belt connecting piece, 40507-a stirring paddle up-down motion sliding rail, 406-a stirring paddle code disc, 40601-a stirring paddle code disc limiting groove, 40602-a stirring paddle code disc limiting optocoupler, 407-a stirring rod, 408-a stirring paddle cleaning station, 40801-a stirring paddle cleaning station inlet, 40802-a stirring paddle cleaning cavity, 40803-a stirring paddle cleaning liquid inlet, 40804-a stirring paddle cleaning station liquid outlet and 40805-a stirring paddle cleaning cavity liquid outlet; The device comprises a 5-reaction and detection module, a 501-reaction disc assembly, a 50101-reaction disc, a 50102-reaction cup position, a 502-reaction disc moving assembly, a 50201-reaction disc moving motor, a 50202-reaction disc moving driving wheel, a 50203-reaction disc moving belt, a 50204-reaction disc moving driven wheel, a 503-reaction disc rotating shaft, a 504-detection light source, a 505-spectrometer box, a 506-reaction disc code disc, a 50601-reaction disc code disc limit groove, a 50602-reaction disc code disc limit optical coupler I, a 50603-reaction disc code disc limit baffle plate, a 50604-reaction disc code disc limit optical coupler II, 507-heating film, 508-heat preservation layer, 509-temperature sensor, 5010-flow guiding structure, 5012-cooling fin, 5013-spectrometer box bracket, 5014-spectrometer box component; 6-a reaction cup cleaning module; 601-cleaning needle assembly, 60101-cleaning needle group, 60102-wiping head, 60103-liquid inlet needle, 60104-liquid discharge needle, 60105-wiping head groove, 60106-limit bolt, 60107-groove pipeline, 60108-cleaning needle assembly bracket, 60109-cleaning needle spring seat, 601010-cleaning needle spring, 601011-cleaning needle fixing head, 601012-wiping head rod, 602-cleaning needle movement support rod, 603-cleaning needle up-down movement assembly, 60301-cleaning needle up-down movement motor, 60302-motor shaft connecting rod, 60303-connecting rod sliding block, 60304-sliding groove block, 60305-cleaning needle moving spring; 7-a base; 8-reaction cup, 801-reaction cup detection window; the device comprises a 9-sample code scanning device, a 901-sample tube rotating assembly, a 90101-rubber ring, a 90102-sample tube rotating motor, a 90103-pulley and a 902-code scanning assembly; 90201-code scanner, 90202-code scanner bracket.
Detailed Description
As shown in fig. 1 to 4, the full-automatic biochemical analyzer of the present embodiment includes a sample injection module 1, a sample filling module 2, a reagent filling module 3, a reaction and detection module 5, a stirring and mixing module 4 and a reaction cup cleaning module 6; the sample filling module 2, the reagent filling module 3, the reaction and detection module 5, the stirring and mixing module 4 and the reaction cup cleaning module 6 are all arranged on the base 7; the sample injection module 1 transmits a sample to be detected to a preset sampling position, and when the full-automatic biochemical analyzer of the embodiment detects the sample according to the requirement of the sample to be detected, the sample injection module 1 transmits the sample to be detected to a sampling position matched with the full-automatic biochemical analyzer, and the sample to be detected is moved to the reaction and detection module 5 for detection through the sample filling module 2; the reagent filling module 3 is used for filling a reagent into a sample to be detected, the stirring and mixing module 4 is used for stirring and mixing the sample to be detected and the reagent, and the reaction cup cleaning module 6 is used for cleaning the reaction cup 8.
The reaction cup cleaning module 6 and the stirring and mixing module 4 are arranged around the reaction and detection module 5; the sample filling module 2 is arranged on the side face of the sample injection module 1, and the sample filling module 2 and the reagent filling module 3 are both positioned on the side face of the reaction and detection module 5.
The full-automatic biochemical analyzer of the embodiment is provided with an operation screen, which is a 10-inch display touch screen and can be externally connected with a keyboard and a mouse; the touch screen can be used for controlling the operation of the instrument and inputting information, and meanwhile, the information such as a detection result, a curve, the state of the instrument and the like can be checked.
The sample injection module 1 and the base 7 are mutually independent, so that the adaptation degree of the sample injection module 1 is enlarged; as shown in fig. 5-14, the sample injection module 1 includes a sample rack 101, at least one sample tube 102 is placed on the sample rack 101, and 10 sample tubes 102 are placed on the sample rack 101 in this embodiment, as shown in fig. 5; the sample rack 101 is driven by the sample in-out conveying component 103 to perform conveying action; the sample injection module 1 further comprises a sample injection assembly 105 and a sampling hand pulling assembly 104, wherein the sample injection assembly 105 performs sample injection on the sample rack 101, and the sampling hand pulling assembly 104 performs pulling on the sample rack 101.
As shown in fig. 6 and 7, the sample in-out conveying assembly 103 comprises a sample in-out conveying belt 10301, the sample rack 101 is connected with the sample in-out conveying belt 10301, specifically, when biochemical analysis is performed, the sample rack 101 is put on the sample in-out conveying belt 10301, and a sample circulation support plate 1012 (shown in fig. 5) is arranged on the side surface of the sample in-out conveying belt 10301, so that sample injection and sample discharge circulation of the sample rack 101 are facilitated; the sample in-out conveying belt 10301 is driven by a sample in-out conveying motor 10302, the sample in-out conveying motor 10302 drives a sample in-out conveying driving wheel 10303 to rotate, and the sample in-out conveying driving wheel 10303 drives a sample in-out synchronous wheel I10304, a sample in-out synchronous wheel II 10305 and a sample in-out synchronous wheel III 10306 to rotate through the sample in-out conveying belt 10301.
The sample injection assembly 105 comprises a sample injection track changing pusher assembly 106 and a sample injection pulling hand assembly 107, as shown in fig. 8 and 9, the sample injection track changing pusher assembly 106 is provided with a sample injection track changing pusher 10601, and the sample injection pulling hand assembly 107 is provided with a sample injection pulling hand 10701; the sample feeding track-changing pushing hand 10601 pushes the sample rack 101 on the sample feeding and discharging conveyor 10301 to the moving range of the sample feeding hand 10701, and the sample feeding hand 10701 dials the sample rack 101 to the moving range of the sample feeding hand assembly 104.
The sample introduction track changing pusher 10601 is connected with the sample introduction track changing pusher slide 10602, as shown in fig. 8 and 9, the sample introduction track changing pusher slide 10602 moves along the sample introduction track changing pusher slide 10603; the sample introduction track pusher block 10602 is connected to a sample introduction track pusher belt 10605 by a sample introduction track pusher belt connection 10604; the sample introduction track change pusher motor 10606 drives the sample introduction track change pusher driving wheel 10607 to rotate, and the sample introduction track change pusher driving wheel 10607 drives the sample introduction track change pusher driven wheel 10608 to rotate through the sample introduction track change pusher belt 10605; it should be noted that the sample introduction track pusher motor 10606 is located within the sample introduction assembly housing 10501.
The sample introduction hand 10701 is connected with a sample introduction hand slide block 10702, and the sample introduction hand slide block 10702 moves along the sample introduction hand slide rail 10703; the sample introduction hand pulling slide block 10702 is connected with a sample introduction hand pulling belt 10705 through a sample introduction hand pulling belt connecting piece 10704; the sample introduction hand-pulling electric machine 10706 drives the sample introduction hand-pulling driving wheel 10707 to rotate, and the sample introduction hand-pulling driving wheel 10707 drives the sample introduction hand-pulling driven wheel 10708 to rotate through the sample introduction hand-pulling belt 10705, as shown in fig. 8 and 9.
The sample injection module 1 further comprises a sample injection blocking component 108, as shown in fig. 12, a sample injection blocking member 10801 in the sample injection blocking component 108 is used for blocking the sample rack 101; the motor shaft of the sample blocking motor 10802 is sequentially connected with a sample blocking baffle 10803 and a sample blocking member 10801, one end of the sample blocking baffle 10803 extends out of the sample blocking baffle one 10804, and the other end extends out of the sample blocking baffle two 10805; a first sample blocking optocoupler 10806 and a second sample blocking optocoupler 10807 are respectively arranged above and below the sample blocking baffle 10803; when the sample blocking optocoupler II 10807 senses the sample blocking baffle II 10805, the sample blocking member 10801 blocks the sample frame 101; when the sample blocking optocoupler 10806 senses the sample blocking baffle 10804, the sample blocking member 10801 releases the sample rack 101, so that the sample rack 101 is driven by the sample in-out conveying component 103 to perform the conveying action.
The sample injection module 1 further comprises a sample outlet blocking component 109, as shown in fig. 13, a sample outlet blocking component 10901 in the sample outlet blocking component 109 is used for blocking the sample rack 101; the motor shaft of the sample outlet blocking motor 10902 is sequentially connected with a sample outlet blocking baffle 10903 and a sample outlet blocking member 10901, one end of the sample outlet blocking baffle 10903 extends out of a first sample outlet blocking baffle 10904, and the other end extends out of a second sample outlet blocking baffle 10905; a first sample blocking optical coupler 10906 and a second sample blocking optical coupler 10907 are respectively arranged above and below the sample blocking baffle 10903; when the second sample blocking optical coupler 10907 senses the second sample blocking baffle 10905, the second sample blocking baffle 10901 blocks the sample rack 101; when the first sample blocking optocoupler 10906 senses the first sample blocking baffle 10904, the first sample blocking member 10901 releases the sample rack 101, so that the sample rack 101 is driven by the sample in-out conveying assembly 103 to perform conveying action.
The sampling hand assembly 104 comprises a sampling hand 10401, as shown in fig. 10, the sampling hand 10401 is composed of a first sampling hand 10402 and a second sampling hand 10403, and the first sampling hand 10402 and the second sampling hand 10403 are respectively connected to two ends of the sampling hand 10404; the sampling shifting hand 10401 is connected with a sampling shifting hand sliding block 10405, and the sampling shifting hand sliding block 10405 moves along a sampling shifting hand sliding rail 10406; the sampling handle sliding block 10405 is connected with a sampling handle belt 10408 through a sampling handle belt connecting piece 10407, the sampling handle driving wheel 104010 is driven to rotate by a sampling handle hand-pulling machine 10409, and the sampling handle driving wheel 104010 drives the sampling handle driven wheel 104011 to rotate through the sampling handle belt 10408.
The sampling hand belt connector 10407 is provided with a first sampling hand baffle 104012 and a second sampling hand baffle 104013 in opposite directions; the first sampling hand 104012 contacts the sample rack 101 to push the sample rack 101 to move towards the sampling position, when the first sampling hand optocoupler 104014 senses the first sampling hand blocking piece 104012, the sampling hand 10401 moves reversely, when the second sampling hand optocoupler 104015 senses the second sampling hand blocking piece 104013, the second sampling hand 10403 contacts the sample rack 101 to continuously stir the sample rack 101 to move towards the original movement direction, and after sample sampling is completed, the second sampling hand 10403 stirs the sample rack 101 to enter the movement range of the sample discharging hand component 1010.
The sample hand assembly 1010 has a sample hand 101001 as shown in FIG. 11; the sample pulling hand 101001 is connected with a sample pulling hand sliding block 101002, and the sample pulling hand sliding block 101002 moves along a sample pulling hand sliding rail 101003; the sample discharging handle sliding block 101002 is connected with a sample discharging handle belt 101005 through a sample discharging handle belt connecting piece 101004; the sample discharging hand-pulling electric machine 101006 drives the sample discharging hand-pulling driving wheel 101007 to rotate, and the sample discharging hand-pulling driving wheel 101007 drives the sample discharging hand-pulling driven wheel 101008 to rotate through the sample discharging hand-pulling belt 101005.
The sample injection module 1 is provided with an emergency detection component 1011, as shown in fig. 14, the emergency detection component 1011 includes an emergency detection position 101101, and the emergency detection position 101101 is used for placing a sample; the emergency detection assembly 1011 further comprises an emergency detection motor 101102, the emergency detection motor 101102 drives the emergency detection screw 101103 to rotate, and an emergency detection screw nut 101104 on the emergency detection screw 101103 is connected with an emergency detection screw nut connector 101105; the emergency detection screw nut connector 101105 is connected with the emergency detection position 101101, and the emergency detection screw nut connector 101105 moves along the emergency detection sliding rail 101107 through the emergency detection sliding block 101106.
It should be noted that, in the sample injection module 1 of this embodiment, a sample rack 101 can hold 10 samples at a time, support standard cups, microcups and test tubes, and support barcode scanning, if barcodes are attached to the test tubes, the instrument will automatically recognize the barcodes to read information; the sample feeding track (i.e. in the running direction of the sample feeding and discharging conveyor 10301) comprises 1 emergency detection position 101101, and the sample to be detected can be placed in the emergency detection position 101101 for emergency test.
The length part (sample feeding track) of the sample feeding and discharging conveyor 10301 on the side surface of the base 7 can be divided into three partial areas, namely a sample feeding area, a sample sucking area and a sample discharging area; the sample injection area is used for storing samples to be tested, the sample suction area is used for completing sample sampling, the sample discharge area is used for storing samples to be tested, the sample injection area belongs to the moving range of the sample injection assembly, the sample suction area belongs to the moving range of the sample sampling hand pulling assembly 104, and the sample discharge area belongs to the moving range of the sample discharge hand pulling assembly 1010.
The sample injection modules 1 of this embodiment may be further multiple, and two adjacent sample injection modules are spliced together, so that the sample rack 101 is transferred to a position farther than the sampling position of the full-automatic biochemical analyzer of this embodiment through the multiple spliced sample injection modules 1.
15-20, The sample needle 201 of the sample filling module 2 quantitatively removes the sample to be detected into a reaction cup located in the reaction and detection module 5, and the sample needle 201 after the sample removal is cleaned in the sample needle cleaning station 202; sample needle 201 (sample needle head 20101 is located at the bottommost part of sample needle 201, as shown in fig. 17) is mounted on sample needle swing arm 203, sample needle swing arm 203 is connected with sample needle spline shaft 204; the sample needle horizontal movement assembly 205 realizes the horizontal rotation movement of the sample needle 201 by driving the sample needle spline shaft 204 to rotate, and the sample needle up-and-down movement assembly 206 realizes the up-and-down movement of the sample needle 201 by driving the sample needle spline shaft 204 to move up and down.
Sample needle guard assembly 207 is arranged on sample needle swing arm 203, sample needle 201 is fixedly connected with sample needle swing arm 203 through sample needle seat 208, spring bolt 20701 of sample needle guard assembly 207 is fixedly connected on sample needle seat 208, and spring 20702 is sleeved on spring bolt 20701.
The top end of the sample needle 201 is connected with a sample needle liquid path interface 209 for connecting with a cleaning liquid to clean the inner wall of the sample needle 201; sample needle blocking pieces 2011 are arranged on a sample needle connecting piece 2010 connected with the sample needle seat 208, the sample needle blocking pieces 2011 are matched with sample needle sensing optocouplers 2012 on the sample needle swing arms 203 to sense the accidental bottoming condition of the sample needle 201 and feed back sensing signals to an instrument CPU, and then the sample needle up-and-down movement assembly 206 is controlled to correct false actions.
The sample needle cleaning station 202 includes a sample needle cleaning liquid inlet 20201, the sample needle cleaning liquid inlet 20201 communicating with the sample needle cleaning chamber 20202; the side of the sample needle cleaning chamber 20202 is provided with a cleaning liquid protecting block 20203, and the waste liquid after cleaning the sample needle 201 is discharged through a cleaning liquid discharging port 20204.
The sample needle horizontal movement assembly 205 comprises a sample needle horizontal movement motor 20501, the sample needle horizontal movement motor 20501 drives a sample needle horizontal movement driving wheel 20502 to rotate, and the sample needle horizontal movement driving wheel 20502 drives a sample needle horizontal movement driven wheel 20504 to rotate through a sample needle horizontal movement belt 20503; sample needle code disc 2013 is arranged below sample needle horizontal movement driven wheel 20504, sample needle spline shaft 204 is driven to rotate by sample needle horizontal movement driven wheel 20504, and sample needle code disc 2013 synchronously rotates with sample needle 201.
Sample needle limit groove 201301 is arranged on sample needle code disc 2013, sample needle limit groove 201301 is matched with sample needle limit optocoupler 201302, and the sample to be detected is moved and taken by sample needle 201, the sample to be detected is released, and the cleaning action is identified and controlled.
The sample needle up-and-down moving assembly 206 includes a sample needle up-and-down moving motor 20601, the sample needle up-and-down moving motor 20601 driving the sample needle up-and-down moving driving wheel 20602 to rotate, and the sample needle up-and-down moving driving wheel 20602 driving the sample needle up-and-down moving driven wheel 20604 to rotate through a sample needle up-and-down moving belt 20603; the sample needle spline shaft 204 is connected to the sample needle up-and-down moving slider 20605, and the sample needle up-and-down moving belt 20603 drives the sample needle up-and-down moving slider 20605 to move along the sample needle up-and-down moving slide rail 20606.
The sample needle 201 sucks a set amount of sample to be detected from the sample container (sample tube 102) and then adds to the cuvette 8; meanwhile, the sample needle 201 also has the functions of liquid level detection, anti-collision detection and needle blocking detection, and the functions belong to the prior art, and no improvement is made in the invention; during analysis: the sample needle 201 is sequentially rotated, lowered, and raised in the order of "sample vessel→cuvette→sample needle cleaning bath". The sample needle 201 is cleaned after each sample to be tested is added. The inner and outer walls of the sample needle 201 are cleaned in the sample needle cleaning station 202.
The reagent needle 301 of the reagent filling module 3 moves the reaction reagent into the reaction cuvette in the reaction and detection module 5; as shown in fig. 21 to 26, the reagent needle 301 is mounted on a reagent needle swing arm 302, and the reagent needle swing arm 302 is connected with a reagent needle spline shaft 303; the reagent needle horizontal movement assembly 304 realizes horizontal movement of the reagent needle 301 by driving the reagent needle spline shaft 303 to rotate, and the reagent needle vertical movement assembly 305 realizes vertical movement of the reagent needle 301 by driving the reagent needle spline shaft 303 to move up and down.
The reagent needle left-right movement assembly 304 includes a reagent needle left-right movement motor 30401, the reagent needle left-right movement motor 30401 drives a reagent needle left-right movement driving wheel 30402 to rotate, the reagent needle left-right movement driving wheel 30402 drives a reagent needle left-right movement driven wheel 30404 to rotate through a reagent needle left-right movement belt 30403, and the reagent needle spline shaft 303 is driven to rotate through a reagent needle left-right movement driven wheel 30404.
The reagent needle up-and-down motion assembly 305 comprises a reagent needle up-and-down motion motor 30501, the reagent needle up-and-down motion motor 30501 drives a reagent needle up-and-down motion driving wheel 30502 to rotate, and the reagent needle up-and-down motion driving wheel 30502 drives a reagent needle up-and-down motion driven wheel 30504 to rotate through a reagent needle up-and-down motion belt 30503; the reagent needle spline shaft 303 is connected with the reagent needle up-and-down movement slider 30505, and the reagent needle up-and-down movement belt 30503 drives the reagent needle up-and-down movement slider 30505 to move along the reagent needle up-and-down movement slide rail 30507 through the reagent needle up-and-down movement belt connector 30506.
The reaction reagent transferred by the reagent needle 301 is contained in the reagent disk 306, and the reagent disk 306 includes an inner ring 30602 and an outer ring 30601, wherein the outer ring 30601 houses the outer ring reagent R1, and the inner ring 30602 houses the inner ring reagent R2.
The reagent disk 306 is driven to rotate by the reagent disk rotating assembly 307, the reagent disk rotating assembly 307 comprises a reagent disk rotating motor 30701, the reagent disk rotating motor 30701 drives the reagent disk rotating driving wheel 30702 to rotate, and the reagent disk rotating driving wheel 30702 drives the reagent disk rotating driven wheel 30704 to rotate through a reagent disk rotating belt 30703; the reagent disk 306 moves the reagent disk rotation shaft 30705 in rotation via the reagent disk rotation driven wheel 30704.
The lower part of the reagent disk rotating shaft 30705 is connected with a reagent disk code disk 308, and a reagent disk limiting groove 30801 and a reagent disk limiting piece 30802 are arranged on the reagent disk code disk 308; the reagent disk limiting groove 30801 is matched with the first reagent disk limiting optocoupler 30803, and the reagent disk limiting piece 30802 is matched with the second reagent disk limiting optocoupler 30804.
A code scanning window 309 is arranged on one side of the reagent disk 306, and a reagent bottle code scanner 3010 scans codes of reagent bottles positioned at the position of the code scanning window 309; a reagent disk cooling assembly (two sets) is arranged below the reagent disk 306, specifically a peltier 3011 and a reagent disk cooling fin 3012, and an exhaust fan 3013 is arranged below the reagent disk cooling fin 3012, as shown in fig. 24.
The reagent tray 306 is used for placing a reagent bottle and sending a reagent and an alkaline cleaning solution to the suction position of the reagent needle 301. The cooling system consisting of the Peltier 3011, the reagent disk cooling fins 3012 and the exhaust fan 3013 can cool the reagent disk 306, so that the reagent can be stored at low temperature; a bar code reader window may also be provided to scan the bar code on the reagent bottle.
The reagent needle 301 sucks a set amount of reagent from the reagent bottle and adds the reagent to the reaction cup 8 in the reaction and detection module 5; the reagent needle 301 is also a liquid level sensor (belonging to the prior art), and the reagent remaining amount is calculated by the descending distance of the reagent needle 301; when biochemical analysis is performed: the reagent needle 301 is sequentially circulated and moved in the order of the reagent bottle, the cuvette, and the reagent needle cleaning station (the structure is the same as that of the sample needle cleaning station 202).
The stirring and evenly mixing module 4 comprises a stirring paddle 401, as shown in fig. 27-32, the stirring paddle 401 is driven by a stirring motor 402 to perform stirring action, as shown in fig. 29; the stirring paddle 401 is connected with a stirring paddle spline shaft 403, a stirring paddle left-right movement component 404 realizes the left-right movement of the stirring paddle 401 by driving the stirring paddle spline shaft 403 to rotate, and a stirring paddle up-down movement component 405 realizes the up-down movement of the stirring paddle 401 by driving the stirring paddle spline shaft 403 to move up and down.
The paddle left-right movement assembly 404 comprises a paddle left-right movement motor 40401, the paddle left-right movement motor 40401 drives the paddle left-right movement driving wheel 40402 to rotate, the paddle left-right movement driving wheel 40402 drives the paddle left-right movement driven wheel 40404 to rotate through the paddle left-right movement belt 40403, and the paddle spline shaft 403 is driven to rotate through the paddle left-right movement driven wheel 40404.
The stirring paddle up-and-down motion assembly 405 comprises a stirring paddle up-and-down motion motor 40501, the stirring paddle up-and-down motion motor 40501 drives a stirring paddle up-and-down motion driving wheel 40502 to rotate, and the stirring paddle up-and-down motion driving wheel 40502 drives a stirring paddle up-and-down motion driven wheel 40504 to rotate through a stirring paddle up-and-down motion belt 40503; the paddle spline shaft 403 is connected to the paddle up-and-down motion slide 40505, and the paddle up-and-down motion belt 40503 drives the paddle up-and-down motion slide 40505 to move along the paddle up-and-down motion slide rail 40507 via the paddle up-and-down motion belt connector 40506.
The stirring and mixing module 4 is also provided with a stirring paddle code wheel 406, and the stirring paddle code wheel 406 is provided with a stirring paddle code wheel limit groove 40601; the stirring paddle code wheel limit groove 40601 is matched with the stirring paddle code wheel limit optocoupler 40602 and is used for identifying the stirring of the stirring paddle 401 and the cleaning position after the stirring paddle 401 is stirred.
The stirring paddle 401 is connected with a stirring motor 402 through a stirring rod 407; the stirring and mixing module 4 is further provided with a stirring paddle cleaning station 408 for cleaning the stirring paddles 401; the paddle cleaning station 408 includes a paddle cleaning station inlet 40801, and the paddle cleaning station inlet 40801 communicates with the paddle cleaning fluid inlet 40803 through a paddle cleaning chamber 40802; the end face of the paddle cleaning liquid inlet 40803 is lower than the end face of the paddle cleaning station 408, and the splashed liquid flows out through the paddle cleaning station drain 40804; the paddle wash chamber 40802 communicates with the paddle wash station drain 40804 through the paddle wash chamber drain 40805.
The stirring paddle 401 stirs the reaction liquid (sample and reagent) in the reaction cup 8; the biochemical analysis is as follows: swinging according to a reaction cup-stirring paddle cleaning station; sequentially descending, rotating the stirring rod, ascending and stopping rotating the stirring rod at two positions; when the stirring paddle 401 is used for cleaning, the stirring paddle 401 moves to the inlet 40801 of the stirring paddle cleaning station, moves downwards into the stirring paddle cleaning cavity 40802, cleaning liquid enters from the stirring paddle cleaning liquid inlet 40803 at the side surface of the stirring paddle cleaning station 408, the stirring paddle 401 is sprayed and washed, the stirring paddle cleaning cavity 40802 is internally provided with the stirring paddle cleaning cavity liquid outlet 40805, waste liquid flows out from the stirring paddle cleaning cavity liquid outlet 40805, meanwhile, other splashed liquid flows out from the stirring paddle cleaning station liquid outlet 40804 and finally flows out from the stirring paddle cleaning station liquid outlet 40804 to enter a liquid path liquid outlet system (which belongs to the prior art and is not improved).
As shown in fig. 33-39, the reaction and detection module 5 includes a reaction tray assembly 501, the reaction tray assembly 501 has a reaction tray 50101, a plurality of reaction cup positions 50102 are provided in the reaction tray 50101, the reaction cup positions 50102 are used for placing reaction cups 8, the reaction tray 50101 of this embodiment has 81 reaction cups (the test speed is fast, the number of the reaction tray holes is large, there are 81 reaction cups, the sample is detected in multiple flux, the detection efficiency is improved), the reaction cups are fixed on the reaction tray 50101, the reaction liquid is reacted in a constant temperature tank at 37 ℃, and absorbance measurement is performed in the rotation, the reaction cups 8 are biochemical reaction carriers; the reaction disk 50101 is driven to rotate by the reaction disk moving component 502 through the reaction disk rotating shaft 503, the optical signal of the light emitted by the detection light source 504 after passing through the reaction cup 8 is received by the spectrometer box 505, and detection analysis is performed on the optical signal (a reaction cup detection window 801 is arranged on the side surface of the reaction cup 8, and the spectrometer box 505 detects the liquid after reaction through the reaction cup detection window 801); when the reaction disk 50101 rotates, the absorbance of the pure water or the reaction solution in the reaction cup 8 is measured.
The reaction plate moving assembly 502 comprises a reaction plate moving motor 50201, the reaction plate moving motor 50201 drives a reaction plate moving driving wheel 50202 to rotate, the reaction plate moving driving wheel 50202 drives a reaction plate moving driven wheel 50204 to rotate through a reaction plate moving belt 50203, and the reaction plate moving driven wheel 50204 drives a reaction plate rotating shaft 503 to rotate.
A reaction disc code disc 506 is arranged in the reaction and detection module 5, a reaction disc code disc limit groove 50601 is arranged on the reaction disc code disc 506 corresponding to each reaction cup position 50102, and a reaction disc code disc limit optocoupler 50602 is matched with the reaction disc code disc limit groove 50601 to identify each detection position; the reaction disc code disc 506 is also provided with a reaction disc code disc limiting baffle 50603, and the second reaction disc code disc limiting optocoupler 50604 is matched with the reaction disc code disc limiting baffle 50603 to identify the rotation number of the reaction disc 50101.
The bottom surface of each reaction cup position 50102 of the reaction disk 50101 is provided with a heating film 507, and the reaction disk 50101 is also provided with a heat preservation layer 508; a temperature sensor 509 is also arranged below the reaction plate 50101 to monitor the temperature so that the temperature of the thermostatic bath is kept at 37 ℃; a flow guiding structure 5010 is arranged on the side face of the reaction disc 50101 and is used for guiding the leakage liquid in the reaction disc 50101.
A heat sink 5012 is provided at the lower part of the detection light source 504; the spectrometer cassette 505 is supported by a spectrometer cassette holder 5013, and the detection light source 504, the heat sink 5012, the spectrometer cassette 505, and the spectrometer cassette holder 5013 constitute a spectrometer cassette assembly 5014.
The cuvette cleaning module 6 comprises a cleaning needle assembly 601, as shown in fig. 40-44, the cleaning needle assembly 601 comprises at least one cleaning needle group 60101 and a wiping head 60102, and the cleaning needle group 60101 comprises a liquid inlet needle 60103 and a liquid outlet needle 60104; the cleaning needle assembly 601 is connected with the cleaning needle moving support rod 602, and the cleaning needle assembly 601 is driven to move up and down by the cleaning needle up-and-down moving assembly 603 through the cleaning needle moving support rod 602.
The cleaning needle up-and-down movement assembly 603 comprises a cleaning needle up-and-down movement motor 60301, the cleaning needle up-and-down movement motor 60301 drives a motor shaft connecting rod 60302 to rotate, and a connecting rod sliding block 60303 is connected to the motor shaft connecting rod 60302; the connecting rod sliding block 60303 moves left and right in the sliding groove of the sliding groove block 60304 to drive the cleaning needle moving support rod 602 to move up and down; the cleaning needle moving rod 602 is connected to the slide groove block 60304, and the cleaning needle moving rod 602 is provided with a cleaning needle moving spring 60305 below the slide groove block 60304, as shown in fig. 40 and 41.
The wiping head 60102 has a wiping head groove 60105, and the wiping head groove 60105 and the stopper 60106 are clamped so that the wiping head 60102 is connected with the wiping head lever 601012; a recessed line 60107 is provided at the bottom surface of the wiper head 60102 as shown in fig. 43.
The cleaning needle assembly 601 further comprises a cleaning needle assembly support 60108, as shown in fig. 44, and the cleaning needle assembly 60101 is connected below the cleaning needle assembly support 60108; a cleaning needle spring seat 60109 is arranged on the cleaning needle assembly bracket 60108, a cleaning needle spring 601010 is arranged on the cleaning needle spring seat 60109, and a cleaning needle fixing head 601011 is arranged above the cleaning needle spring 601010; the cleaning needle group 60101, the cleaning needle spring seat 60109 and the cleaning needle fixing head 601011 are assembled to form an integrated cleaning needle group, and are in non-fixed connection with the cleaning needle component bracket 60108, and the cleaning needle spring 601010 is sleeved on the integrated cleaning needle group; the cleaning needle assembly 601 of the present embodiment has 3 cleaning needle groups 60101 and 1 wiping head 60102 (the transmission is a link structure), wherein each cleaning needle group 60101 has a liquid inlet needle 60103 and a liquid outlet needle 60104.
The reaction cup cleaning module 6 realizes the functions of sucking away the reaction liquid after the reaction is finished, cleaning the reaction cup, adding and pumping away the pure water for blank of the test cup; in this embodiment, as shown in fig. 48, the cuvette is cleaned by the cleaning needle assembly 601, and the cleaning requires 8 processes (each needle is cleaned twice), so that one cuvette needs to be cleaned in 8 steps.
45-47, The full-automatic biochemical analyzer of the present embodiment further includes a sample code scanning device 9, where the sample code scanning device 9 is located at the side of the sample filling module 2; the sample code scanning device 9 comprises a sample tube rotating assembly 901 and a code scanning assembly 902; the code scanning assembly 902 comprises a code scanner 90201, the sample tube rotating assembly 901 comprises a rubber ring 90101, and the rubber ring 90101 rubs the sample tube 102 to enable the sample tube 102 to rotate; the code scanner 90201 scans the sample tube 102 at different angles to finish code scanning of the sample tube 102 and input sample information; the code scanner assembly 902 further comprises a code scanner bracket 90202, and the code scanner 90201 is arranged on the code scanner bracket 90202; the sample tube rotating assembly 901 comprises a sample tube rotating motor 90102, a rubber ring 90101 is sleeved on a pulley 90103, and the pulley 90103 is arranged on a motor shaft of the sample tube rotating motor 90102; the sample code scanning device 9 enables the full-automatic biochemical analyzer of the embodiment to have an automatic rotating code scanning function during sample injection of a sample tube.
After the full-automatic biochemical analyzer is started, resetting (cleaning a reaction cup) is firstly carried out, a light source to be detected is stable, the temperature of a reaction disk is balanced, meanwhile, a reagent needle 301, a sample needle 201 and a stirring paddle 401 are stopped above respective cleaning stations, after the first reagent R1 is added into the reagent needle, the sample is added into the sample needle, stirring (if the reagent needle is a double-reagent item, the second reagent R2 is added into the reagent needle after stirring), absorbance measurement, cleaning the reaction cup and shutdown are carried out; 81 reaction cups, 12 seconds per cycle, one revolution. And (5) stopping after clockwise rotation for 1 circle and 20 cup positions within 12 seconds in each period, and completing the actions of adding the reagent R1, the sample to be detected and the reagent R2. Every four cycles, 80 cup positions are rotated, and one cup position is gradually moved in the opposite direction; the single reagent test is carried out reaction and photometry after the stirring of S, and the double reagent is carried out reaction and photometry after the stirring of the reagent R2; the test flow of the fully automatic biochemical analyzer is shown in fig. 49.
The foregoing has outlined and described the basic principles, features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present invention, and various changes and modifications may be made without departing from the spirit and scope of the invention, which is defined in the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (18)

1. The full-automatic biochemical analyzer is characterized by comprising a sample injection module, a sample filling module, a reagent filling module, a reaction and detection module, a stirring and mixing module and a reaction cup cleaning module; the sample filling module, the reagent filling module, the reaction and detection module, the stirring and mixing module and the reaction cup cleaning module are all arranged on the base; the sample injection module transmits a sample to be detected to a preset sampling position, and the sample to be detected is moved to the reaction and detection module for detection through the sample filling module; the reagent filling module is used for filling a reagent into a sample to be detected, the stirring and mixing module is used for stirring and mixing the sample to be detected and the reagent uniformly, and the reaction cup cleaning module is used for cleaning a reaction cup;
The sample feeding modules comprise a plurality of sample racks, and two adjacent sample feeding modules are spliced together, so that the sample racks are transmitted to positions farther than the preset sampling positions through the spliced sample feeding modules; the full-automatic biochemical analyzer is provided with an operation screen;
The sample injection module and the base are mutually independent, so that the adaptation degree of the sample injection module is enlarged; at least one sample tube is placed on the sample rack; the sample rack is driven by the sample inlet and outlet conveying component to carry out conveying action; the sample injection module further comprises a sample injection assembly and a sampling hand pulling assembly, wherein the sample injection assembly performs sample injection on the sample rack, and the sampling hand pulling assembly performs pulling on the sample rack;
The sampling hand assembly comprises a sampling hand, wherein the sampling hand consists of a first sampling hand and a second sampling hand, and the first sampling hand and the second sampling hand are respectively connected to two ends of a sampling hand arm; the sampling handle is connected with a sampling handle sliding block, and the sampling handle sliding block moves along a sampling handle sliding rail; the sampling hand pulling slide block is connected with a sampling hand pulling belt through a sampling hand pulling belt connecting piece, the sampling hand pulling machine drives a sampling hand pulling driving wheel to rotate, and the sampling hand pulling driving wheel drives a sampling hand pulling driven wheel to rotate through the sampling hand pulling belt;
The sampling hand-pulling belt connecting piece is provided with a first sampling hand-pulling blocking piece and a second sampling hand-pulling blocking piece; the first sampling hand contacts the sample frame to push the sample frame to move towards a sampling position, when the first sampling hand optical coupler senses the first sampling hand blocking piece, the sampling hand moves reversely, when the second sampling hand optical coupler senses the second sampling hand blocking piece, the second sampling hand contacts the sample frame to continuously stir the sample frame to move towards an original movement direction, and after sample sampling is completed, the second sampling hand stirs the sample frame to enter the movement range of the sample discharging hand assembly.
2. The fully automatic biochemical analyzer according to claim 1, wherein the sample in-out conveying assembly comprises a sample in-out conveying belt, and the sample rack is placed on the sample in-out conveying belt; the sample feeding and discharging conveying belt is driven by a sample feeding and discharging conveying motor, the sample feeding and discharging conveying motor drives a sample feeding and discharging conveying driving wheel to rotate, and the sample feeding and discharging conveying driving wheel drives a sample feeding and discharging synchronous wheel I, a sample feeding and discharging synchronous wheel II and a sample feeding and discharging synchronous wheel III to rotate through the sample feeding and discharging conveying belt.
3. The fully automatic biochemical analyzer according to claim 2, wherein the sample injection assembly comprises a sample injection track changing pusher assembly and a sample injection hand pulling assembly, the sample injection track changing pusher assembly is provided with a sample injection track changing pusher, and the sample injection hand pulling assembly is provided with a sample injection hand pulling; the sample feeding track-changing pushing hand pushes a sample rack on the sample feeding and discharging conveying belt to the moving range of the sample feeding pulling hand, and the sample rack is pulled to the moving range of the sample feeding pulling hand assembly by the sample feeding pulling hand.
4. The fully automatic biochemical analyzer according to claim 3, wherein the sample introduction track changing pusher is connected with a sample introduction track changing pusher slide, and the sample introduction track changing pusher slide moves along a sample introduction track changing pusher slide rail; the sample injection track-changing pusher slide block is connected with the sample injection track-changing pusher belt through a sample injection track-changing pusher belt connecting piece; the sample injection track-changing pusher motor drives the sample injection track-changing pusher driving wheel to rotate, and the sample injection track-changing pusher driving wheel drives the sample injection track-changing pusher driven wheel to rotate through the sample injection track-changing pusher belt.
5. The fully automatic biochemical analyzer according to claim 3, wherein the sample introduction hand is connected with a sample introduction hand slide block, and the sample introduction hand slide block moves along a sample introduction hand slide rail; the sample introduction hand pulling sliding block is connected with a sample introduction hand pulling belt through a sample introduction hand pulling belt connecting piece; the sample introduction hand-pulling machine drives the sample introduction hand-pulling driving wheel to rotate, and the sample introduction hand-pulling driving wheel drives the sample introduction hand-pulling driven wheel to rotate through the sample introduction hand-pulling belt.
6. The fully automatic biochemical analyzer according to claim 1, wherein the sample injection module further comprises a sample injection blocking assembly, wherein a sample injection blocking member in the sample injection blocking assembly is used for blocking the sample rack; the motor shaft of the sample injection blocking motor is sequentially connected with the sample injection blocking baffle plate and the sample injection blocking piece, one end of the sample injection blocking baffle plate extends out of the sample injection blocking baffle plate I, and the other end extends out of the sample injection blocking baffle plate II; a first sample injection blocking optical coupler and a second sample injection blocking optical coupler are respectively arranged above and below the sample injection blocking baffle; when the sample blocking optical coupler II senses the sample blocking baffle II, the sample blocking piece blocks the sample rack; when the sample blocking optocoupler senses that the sample blocking baffle is at one time, the sample blocking piece releases the sample rack, so that the sample rack is driven by the sample in-out conveying assembly to perform conveying action.
7. The fully automatic biochemical analyzer according to claim 6, wherein the sample injection module further comprises a sample outlet blocking component, wherein a sample outlet blocking piece in the sample outlet blocking component is used for blocking the sample rack; the motor shaft of the sample discharging blocking motor is sequentially connected with the sample discharging blocking baffle plate and the sample discharging blocking piece, one end of the sample discharging blocking baffle plate extends out of the first sample discharging blocking baffle plate, and the other end of the sample discharging blocking baffle plate extends out of the second sample discharging blocking baffle plate; a first sample-discharging blocking optical coupler and a second sample-discharging blocking optical coupler are respectively arranged above and below the sample-discharging blocking baffle; when the second sample blocking optical coupler senses the second sample blocking baffle plate, the second sample blocking baffle plate blocks the sample frame; when the sample outputting blocking optocoupler senses that the sample outputting blocking baffle is one, the sample outputting blocking piece releases the sample frame, so that the sample frame is driven by the sample outputting and inputting conveying assembly to carry out conveying action.
8. The fully automatic biochemical analyzer according to claim 1, wherein the sample ejection handle assembly has a sample ejection handle, the sample ejection handle is connected with a sample ejection handle slide, and the sample ejection handle slide moves along a sample ejection handle slide rail; the sample discharging handle sliding block is connected with a sample discharging handle belt through a sample discharging handle belt connecting piece; the sample discharging hand-pulling machine drives the sample discharging hand-pulling driving wheel to rotate, and the sample discharging hand-pulling driving wheel drives the sample discharging hand-pulling driven wheel to rotate through the sample discharging hand-pulling belt.
9. The full-automatic biochemical analyzer according to claim 1, wherein the sample injection module is provided with an emergency detection assembly, and the emergency detection assembly comprises an emergency detection position for placing a sample; the emergency detection assembly further comprises an emergency detection motor, the emergency detection motor drives the emergency detection screw rod to rotate, and an emergency detection screw rod nut on the emergency detection screw rod is connected with an emergency detection screw rod nut connecting piece; the emergency detection screw nut connecting piece is connected with the emergency detection position, and the emergency detection screw nut connecting piece moves along an emergency detection sliding rail through an emergency detection sliding block.
10. The fully automated biochemical analyzer according to claim 1, wherein the reagent needle of the reagent filling module moves a reaction reagent into a reaction cuvette located in the reaction and detection module; the reagent needle is arranged on a reagent needle swing arm which is connected with a reagent needle spline shaft; the reagent needle left-right movement assembly realizes the left-right movement of the reagent needle by driving the reagent needle spline shaft to rotate, and the reagent needle up-down movement assembly realizes the up-down movement of the reagent needle by driving the reagent needle spline shaft to move up and down.
11. The full-automatic biochemical analyzer according to claim 10, wherein the reagent needle left-right movement assembly comprises a reagent needle left-right movement motor, the reagent needle left-right movement motor drives a reagent needle left-right movement driving wheel to rotate, the reagent needle left-right movement driving wheel drives a reagent needle left-right movement driven wheel to rotate through a reagent needle left-right movement belt, and the reagent needle spline shaft is driven to rotate through the reagent needle left-right movement driven wheel.
12. The full-automatic biochemical analyzer according to claim 10, wherein the reagent needle up-and-down movement assembly comprises a reagent needle up-and-down movement motor, the reagent needle up-and-down movement motor drives a reagent needle up-and-down movement driving wheel to rotate, and the reagent needle up-and-down movement driving wheel drives a reagent needle up-and-down movement driven wheel to rotate through a reagent needle up-and-down movement belt; the reagent needle spline shaft is connected with the reagent needle up-and-down motion sliding block, and the reagent needle up-and-down motion belt drives the reagent needle up-and-down motion sliding block to move along the reagent needle up-and-down motion sliding rail through the reagent needle up-and-down motion belt connecting piece.
13. The fully automatic biochemical analyzer according to claim 10, wherein the reagent needle is arranged in a reagent tray, the reagent tray includes an inner ring and an outer ring, the outer ring is arranged with an outer ring reagent R1, and the inner ring is arranged with an inner ring reagent R2.
14. The fully automatic biochemical analyzer according to claim 13, wherein the reagent disk is driven to rotate by a reagent disk rotating assembly, the reagent disk rotating assembly comprises a reagent disk rotating motor, the reagent disk rotating motor drives a reagent disk rotating driving wheel to rotate, and the reagent disk rotating driving wheel drives the reagent disk rotating driven wheel to rotate through a reagent disk rotating belt; the reagent disk drives the reagent disk rotating shaft to rotate through the reagent disk rotating driven wheel.
15. The full-automatic biochemical analyzer according to claim 1, wherein the stirring and mixing module comprises a stirring paddle, and the stirring paddle is driven by a stirring motor to perform stirring action; the stirring paddle is connected with a stirring paddle spline shaft, the stirring paddle left-right movement assembly realizes the left-right movement of the stirring paddle by driving the stirring paddle spline shaft to rotate, and the stirring paddle up-down movement assembly realizes the up-down movement of the stirring paddle by driving the stirring paddle spline shaft to move up and down.
16. The full-automatic biochemical analyzer according to claim 1, wherein the reaction and detection module comprises a reaction disk assembly, the reaction disk assembly is provided with a reaction disk, and a plurality of reaction cup positions are arranged in the reaction disk and are used for placing reaction cups; the reaction disk is driven to rotate by the reaction disk movement assembly through the reaction disk rotating shaft, and the optical signals of the detection light source after the emitted light passes through the reaction cup are received by the spectrometer box, so that the detection analysis is carried out on the optical signals.
17. The fully automatic biochemical analyzer according to claim 1, wherein the cuvette washing module comprises a washing needle assembly having at least one washing needle set and a wiping head, the washing needle set comprising a liquid inlet needle and a liquid outlet needle; the cleaning needle assembly is connected with the cleaning needle movement supporting rod, and the cleaning needle up-and-down movement assembly drives the cleaning needle assembly to move up and down through the cleaning needle movement supporting rod.
18. The fully automatic biochemical analyzer according to any one of claims 1 to 17, wherein the cuvette washing module and the stirring and mixing module are arranged around the reaction and detection module; the sample filling module is arranged on the side face of the sample injection module, and the sample filling module and the reagent filling module are both positioned on the side face of the reaction and detection module.
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