CN115211430A - High-stability abamectin composition and preparation - Google Patents
High-stability abamectin composition and preparation Download PDFInfo
- Publication number
- CN115211430A CN115211430A CN202111041332.0A CN202111041332A CN115211430A CN 115211430 A CN115211430 A CN 115211430A CN 202111041332 A CN202111041332 A CN 202111041332A CN 115211430 A CN115211430 A CN 115211430A
- Authority
- CN
- China
- Prior art keywords
- abamectin
- stability
- composition
- carrier
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 101
- 239000005660 Abamectin Substances 0.000 title claims abstract description 81
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 title claims abstract description 68
- 229950008167 abamectin Drugs 0.000 title claims abstract description 68
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 43
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 27
- 238000009472 formulation Methods 0.000 claims abstract description 22
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000000440 bentonite Substances 0.000 claims abstract description 17
- 229910000278 bentonite Inorganic materials 0.000 claims abstract description 17
- 239000006229 carbon black Substances 0.000 claims abstract description 10
- 239000005995 Aluminium silicate Substances 0.000 claims abstract description 3
- 235000012211 aluminium silicate Nutrition 0.000 claims abstract description 3
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims abstract description 3
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims abstract description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229910052901 montmorillonite Inorganic materials 0.000 claims abstract description 3
- -1 cetyl trimethylammonium salt modified bentonite Chemical class 0.000 claims description 33
- 239000002270 dispersing agent Substances 0.000 claims description 19
- 239000000080 wetting agent Substances 0.000 claims description 19
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 17
- 239000002245 particle Substances 0.000 claims description 17
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 17
- 239000000853 adhesive Substances 0.000 claims description 15
- 230000001070 adhesive effect Effects 0.000 claims description 15
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 claims description 13
- 239000002671 adjuvant Substances 0.000 claims description 10
- 239000002861 polymer material Substances 0.000 claims description 10
- 239000004563 wettable powder Substances 0.000 claims description 9
- 239000011230 binding agent Substances 0.000 claims description 8
- 229920002873 Polyethylenimine Polymers 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 229920003169 water-soluble polymer Polymers 0.000 claims description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 5
- 239000008158 vegetable oil Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 229960000484 ceftazidime Drugs 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 229920001400 block copolymer Polymers 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 239000007884 disintegrant Substances 0.000 claims description 2
- 229920001519 homopolymer Polymers 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 239000004562 water dispersible granule Substances 0.000 claims description 2
- 239000000463 material Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 abstract description 24
- 239000002552 dosage form Substances 0.000 abstract description 13
- 241000607479 Yersinia pestis Species 0.000 abstract description 12
- 239000000575 pesticide Substances 0.000 abstract description 7
- 238000004806 packaging method and process Methods 0.000 abstract description 6
- 230000002147 killing effect Effects 0.000 abstract description 5
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 238000003860 storage Methods 0.000 abstract description 3
- 238000002156 mixing Methods 0.000 description 35
- 239000003795 chemical substances by application Substances 0.000 description 26
- 238000005507 spraying Methods 0.000 description 23
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 18
- 239000002253 acid Substances 0.000 description 12
- 238000001035 drying Methods 0.000 description 12
- 238000003756 stirring Methods 0.000 description 11
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 10
- 229910052783 alkali metal Inorganic materials 0.000 description 10
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 8
- 238000000227 grinding Methods 0.000 description 8
- 230000000149 penetrating effect Effects 0.000 description 8
- 235000012424 soybean oil Nutrition 0.000 description 8
- 239000003549 soybean oil Substances 0.000 description 8
- 239000005909 Kieselgur Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 6
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 6
- 239000006260 foam Substances 0.000 description 6
- 239000002917 insecticide Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000004575 stone Substances 0.000 description 6
- 239000011975 tartaric acid Substances 0.000 description 6
- 235000002906 tartaric acid Nutrition 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 5
- 235000017557 sodium bicarbonate Nutrition 0.000 description 5
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000003945 anionic surfactant Substances 0.000 description 3
- 229960002588 cefradine Drugs 0.000 description 3
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 238000006136 alcoholysis reaction Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000000361 pesticidal effect Effects 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
- 241000238876 Acari Species 0.000 description 1
- 241000244206 Nematoda Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 241000872198 Serjania polyphylla Species 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 150000001346 alkyl aryl ethers Chemical class 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004581 coalescence Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920005646 polycarboxylate Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/24—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients to enhance the sticking of the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/20—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom three- or four-membered rings
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the technical field of abamectin pesticides, relates to the technical field of A01N25/12IPC, and particularly relates to a high-stability abamectin composition and a preparation thereof. It comprises 0.1 to 10 weight percent of abamectin, 1 to 10 weight percent of carrier, 0.2 to 10 weight percent of auxiliary agent and the balance of diatomite; the carrier is selected from one or more of talcum powder, modified organic bentonite, white carbon black, kaolin and montmorillonite. The high-stability abamectin composition has excellent stability, has good fluidity when being prepared into a dosage form, and can easily flow from a storage bin to a packaging bag and then flow from the packaging bag to a sprayer for preparation. In addition, the abamectin is treated by adopting a specific carrier and then mixed with the diatomite to prepare a final preparation formulation, so that the fluidity of the powder is remarkably improved, the synergistic effect between the abamectin and the diatomite in the composition is further improved, the pest killing effect is improved, and the dosage of the pesticide is reduced.
Description
Technical Field
The invention relates to the technical field of abamectin pesticides, relates to the technical field of A01N25/12IPC, and particularly relates to a high-stability abamectin composition and a preparation thereof.
Background
The abamectin is a hexadecimal macrolide compound, has strong capabilities of contact poisoning, stomach toxicity, penetration and the like, and has very good effect on the inhibition and killing of pests, mites and the like. Although the abamectin can be used for preventing and controlling pests to a certain extent, and a large amount of pest loss is recovered, the chemical agents not only pollute the environment, but also cause pest resistance and can not eradicate the pest crisis for a long time. In response to these problems, there is a need to combine chemical and physical pesticidal mechanisms to produce pharmaceutical dosage forms that include both chemical pesticidal and physical inhibition.
For example, chinese patent CN201811594784 discloses an insecticide composition for controlling nematode and mite pests, wherein an appropriate amount of abamectin and the balance of diatomaceous earth are compounded to obtain an insecticide composition, and the insecticide composition is mixed with other adjuvants to prepare a wettable powder, and excellent pest control effects are achieved by utilizing physical adsorption of diatomaceous earth and stomach toxicity contact killing of abamectin. However, the formulation of these dosage forms often produces a large amount of dust during manufacture and use. Further, since the particle diameter of the fine particles in these dosage forms such as wettable powder is large, the specific surface area of the fine particles is small, and the effect thereof is yet to be further improved. In addition, in the process of researching the pesticide preparation of abamectin and diatomite, the applicant finds that the dispersibility between the physical pesticide such as diatomite and the abamectin component is poor, and the insecticidal complementarity between the physical pesticide and the abamectin component is not obvious enough. Moreover, in the process of spraying the medicine, especially when the modern wet spraying type medicine application such as an unmanned aerial vehicle is adopted, the higher dilution multiple is found to be needed, otherwise, the blockage of a sprayer nozzle is easily caused, and the medicine spraying amount and the spraying efficiency are influenced. However, the diatom earth physical insecticide component absorbs the body fluid of pests by utilizing the loose structure of the diatom earth physical insecticide component to play a role, the sprayed diluent is required to be volatilized to take effect, and the quick-acting performance of the diatom earth physical insecticide component is further reduced by the high dilution factor.
Disclosure of Invention
In order to solve the technical problems, the first aspect of the invention provides a high-stability abamectin composition, which comprises 0.1-10 wt% of abamectin, 1-10 wt% of a carrier, 0.2-10 wt% of an auxiliary agent and the balance of diatomite; the carrier is selected from one or more of talcum powder, modified organic bentonite, white carbon black, kaolin and montmorillonite.
The abamectin can be prepared from conventional technical products on the market, and the specific source of the abamectin is not specially limited. The diatomite is a product obtained by performing specific crushing treatment on the siliceous sedimentary rock, and the diatomite which is subjected to specific thermal drying treatment and has a fluffy internal structure and a large specific surface area is preferably used in the application, for example, the France Yirui stone Celite610 and the like can be used.
As a preferred technical solution of the present invention, the modified organic bentonite is selected from at least one of hexadecyl trimethyl ammonium salt modified bentonite, ceftazidime modified bentonite, octadecyl trimethyl ammonium salt modified bentonite and octadecyl amine modified bentonite; further, the modified organic bentonite is a mixture of ceftazidime modified bentonite and octadecyl amine modified bentonite; further, the mass of the ceftazidime modified bentonite is at least 1.5 times of that of the octadecyl amine modified bentonite.
Further, the carrier is a mixture of white carbon black and the modified organic bentonite; further, the content of the modified organic bentonite accounts for at least 20-35 wt% of the mass of the carrier. In a preferred embodiment of the present invention, the particle size of the carrier is 80 to 500nm. More preferably, the particle size of the carrier is 150 to 300nm.
The applicant has found that when the composition is prepared into wettable powder, the flowability of the medicament after grinding treatment is not high enough, and the combination property is not good when the composition is further prepared into dosage forms such as effervescent granules and the like. And the prepared wettable powder has large specific surface area and is easy to absorb moisture, and the absorbed moisture leads the diatomite with a large number of microporous structures to absorb moisture in advance, so that the surface of the diatomite becomes sticky, the agglomeration among particles is caused, and the particle size of the particles is increased even if the diatomite is diluted by water during use, thereby causing the spraying effect. In the process of completing the present invention, the applicant finds that the above problems can be significantly improved by performing corresponding optimization and improvement on the carrier used in the composition, and particularly, when a mixture of white carbon black with a specific particle size and the modified organic bentonite is used as the carrier, the flowability of the powder is significantly improved, so that the pest killing effect of the composition is further improved, and the dosage of the drug is reduced.
As a preferable technical scheme of the invention, the auxiliary agent comprises at least one of a dispersant, a wetting agent and a synergist; the synergist comprises vegetable oil.
The specific type of the dispersant in the invention is not particularly limited, and various nonionic surfactants, anionic surfactants and other components well known to those skilled in the art can be selected; further, the anionic surfactant may be a polycarboxylate type anionic surfactant or the like. The specific type of the wetting agent in the present invention is not particularly limited, and various components well known to those skilled in the art may be selected, including but not limited to fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, alkyl phosphate, polyoxyethylene alkylaryl ether, and the like.
The synergist disclosed by the invention is a component which is beneficial to improving the pest control efficiency of the abamectin composition, and the synergist disclosed by the invention comprises vegetable oil, and further the vegetable oil can be epoxidized soybean oil, corn oil and the like; further, the vegetable oil is epoxidized soybean oil; further, the content of the epoxidized soybean oil in the abamectin composition is 0.1-1.5 wt%.
A second aspect of the invention provides an avermectin formulation comprising a high stability avermectin composition as described above, further adjuvants; the content of the abamectin in the preparation is 0.1-8 wt%.
The other auxiliary agents in the invention can be adhesive, effervescent disintegrating agent, diluent, tackifier, adsorbent and the like, and corresponding other auxiliary agent components can be selected for use according to different actual dosage forms.
As a preferable technical scheme, the preparation formulation comprises wettable powder, water dispersible granules and effervescent granules.
The wettable powder is prepared by blending the abamectin with the components such as a carrier, an auxiliary agent and the like, then carrying out high-speed universal grinding so that the abamectin and the carrier can be uniformly mixed with each other, and then adding the diatomite component for mixing; further, the wettable powder is prepared by drying a carrier component at 95 ℃ for 1-2 hours, mixing the carrier component with abamectin, then placing the mixed mixture in a high-pressure mixing kettle, adjusting the pressure of the mixing kettle to 4.8-8.0 MPa, adding a penetrant, carrying out pressure maintaining treatment at 40-50 ℃ for 45-60 min, then releasing the pressure, recovering the penetrant, then taking out the mixture, drying at 60 ℃ for 30min, mixing the mixture with a wetting agent, a dispersing agent and other components, carrying out high-speed universal grinding until the fineness is about 400 meshes, and stirring and mixing the obtained powder with diatomite.
The applicant has found that the flowability of the powders can be better improved by the above preparation method, and in particular when a specific carrier is used, the adsorption of the carrier to abamectin and the stability of the resulting powder particles can be improved by the above treatment. In addition, in this way, the synergistic effect with the adhesive, the effervescent auxiliary agent and the like can be further improved, and the spraying effect of the preparation can be improved.
As a preferred technical scheme of the invention, when the preparation is in the form of effervescent granules, the other auxiliary agents comprise a binder and an effervescent disintegrating agent; the adhesive is a water-soluble high polymer material.
In a preferred embodiment of the present invention, the water-soluble polymer material is selected from one or more of polyoxyethylene-polyoxypropylene block copolymer, polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol, acrylic acid homopolymer, and sodium carboxymethyl cellulose.
Further, the water-soluble high polymer material is a mixture of polyvinyl alcohol and polyethyleneimine; further, the mass ratio of the polyvinyl alcohol to the polyethyleneimine is (3-5): 1; further, the mass ratio of the polyvinyl alcohol to the polyethyleneimine is 4.2:1.
in a preferred embodiment of the present invention, when the concentration of the water-soluble polymer material in water is 0.1 to 1.5wt%, the shear viscosity of the aqueous solution is 1.0 to 15 mPas.
Further, when the concentration of the water-soluble polymer material in water is 0.5 to 1.0wt%, the shear viscosity of the aqueous solution thereof is 1 to 6 mPas.
The term "shear viscosity" as used herein, i.e., the ratio of shear stress to shear rate at steady state, is herein measured at 120rpm at 25 ℃.
Furthermore, the alcoholysis degree of the polyvinyl alcohol is 85-90%, preferably 88%, products such as PVA-1788, PVA-2088, PVA-2288 and the like can be adopted, and the polyvinyl alcohol is preferably PVA-1788 (the polymerization degree is 1700, and the alcoholysis degree is 88%).
The applicant finds that the spraying difficulty of the dosage form can be further reduced by optimizing and compounding the water-soluble high polymer material, and the more uniform droplet size can be ensured under the lower spraying pressure, so that the dosage form can be more uniformly sprayed on a sprayed object. In addition, the applicant finds that the carrier and the water-soluble polymer material in the composition have an obvious synergistic effect, and after the carrier and the water-soluble polymer material are optimized and improved simultaneously, the spraying efficiency of the dosage form can be improved on the premise of adopting less dilution solvent, the conditions of blockage in the spraying process and the like are avoided, and the composition can be widely applied to modern drug delivery by adopting unmanned aerial vehicle spraying and the like.
In the present application, the specific selection of the effervescent disintegration agent is not particularly limited, and conventional components in the field can be selected, and include alkaline metal salts and acids, wherein the alkaline metal salts include but are not limited to sodium carbonate, sodium bicarbonate, potassium carbonate, and the like; the acid is an organic acid including, but not limited to, succinic acid, citric acid, tartaric acid, and the like.
The prepared wettable powder, the adhesive and the effervescent disintegrating agent are fully stirred, mixed uniformly and granulated to obtain the effervescent granules.
As a preferable technical scheme of the invention, under the spraying pressure of 0.10-0.55 MPa, the droplet diameter D50 of the abamectin preparation is 120-190 μm.
The technical scheme provided by the invention has the following beneficial effects:
the high-stability abamectin composition has excellent stability, has good fluidity when being prepared into a dosage form, and can easily flow from a storage bin to a packaging bag and then flow from the packaging bag to a sprayer for preparation. In addition, the abamectin is treated by adopting a specific carrier and then mixed with the diatomite to prepare a final preparation formulation, so that the flowability of the powder is obviously improved, the synergistic effect between the abamectin and the diatomite in the composition is further improved, the pest killing effect is improved, and the dosage of the pesticide is reduced. In addition, through adopting specific carrier and specific adhesive in this application, utilize the key synergism between them, improve the stability of dosage form, make it can keep fine dimensional stability at the spraying in-process, avoid the interparticle coalescence of granule, block up the atomizer shower nozzle, influence spraying effect. The dosage form can be sprayed under the spraying height of 0.6-2 m and the pressure of 0.1-1 MPa, the particle size uniformity of spraying droplets can be realized, the particle size D50 is within the range of 120-190 microns, and the particle size D90 is within the range of 205-235 microns, so that the uniform spraying can be better realized, and the dosage of a reagent is further reduced.
Detailed Description
Example 1
This example provides a high stability avermectin composition, which includes 3.6wt% avermectin, 4wt% carrier, 4.5wt% adjuvant, and the balance diatomaceous earth; the diatomite is Celite610 of France Yirui stone, the average particle size of the carrier is 200nm, the carrier is a mixed mixture of white carbon black and modified organic bentonite, the mass ratio is 3:2, the modified organic bentonite is a mixture of cefradine modified bentonite and octadecylamine modified bentonite, and the mass ratio is 1.5; the auxiliary agent comprises 2wt% of dispersing agent, 1.5wt% of wetting agent and 1wt% of synergist, the dispersing agent is HMK-D1003 of Moke chemical technology Co., ltd, beijing Han, the wetting agent is organosilicon QS-302-NP50 of Sancheng New Material Co., ltd, jiangxi, and the synergist is epoxidized soybean oil.
The embodiment also provides an abamectin foam formulation, which comprises the high-stability abamectin composition and other auxiliary agents, wherein the mass ratio of the high-stability abamectin composition to the other auxiliary agents is 1:1, the other auxiliary agents consist of 4 parts by weight of binding agents and 15 parts by weight of effervescent disintegrating agents, the binding agents are mixtures of polyvinyl alcohol (PVA-1788) and polyethyleneimine (Mw = 70000), and the mass ratio is 4.2:1 (a 0.7wt% aqueous solution thereof has a shear viscosity of 3.2 mPas); the effervescent disintegrating agent consists of 2 parts by weight of acid and 4.5 parts by weight of alkali metal salt, wherein the acid is a mixture of citric acid and tartaric acid, the volume ratio is 1:1, and the alkali metal salt is sodium bicarbonate.
The preparation method of the abamectin bubble formulation comprises the following steps: drying the carrier component for 1.5 hours at 95 ℃, mixing the carrier component with abamectin, then placing the mixed mixture in a high-pressure mixing kettle, adjusting the pressure of the mixing kettle to 5.2MPa, adding a penetrating agent (cyclopentane), carrying out pressure maintaining treatment at 45 ℃, releasing the pressure, recovering the penetrating agent, taking out the mixture, drying the mixture at 60 ℃ for 30 minutes, mixing the mixture with a wetting agent, a dispersing agent and a synergist, carrying out high-speed universal grinding until the fineness is about 400 meshes, stirring and mixing the obtained powder with diatomite to obtain powder, stirring and mixing the obtained powder with an adhesive and an effervescent disintegrant uniformly, and granulating to obtain the composite.
Example 2
This example provides a high stability avermectin composition, which includes 3.6wt% avermectin, 4wt% carrier, 4.5wt% adjuvant, and the balance diatomaceous earth; the diatomite is Celite610 of France Yirui stone, the average particle size of the carrier is 200nm, and the carrier is white carbon black; the auxiliary agent comprises 2wt% of dispersing agent, 1.5wt% of wetting agent and 1wt% of synergist, the dispersing agent is HMK-D1003 of Moke chemical technology Co., ltd, beijing Han, the wetting agent is organosilicon QS-302-NP50 of Sancheng New Material Co., ltd, jiangxi, and the synergist is epoxidized soybean oil.
The embodiment also provides an abamectin foam formulation, which comprises the high-stability abamectin composition and other auxiliary agents, wherein the mass ratio of the high-stability abamectin composition to the other auxiliary agents is 1:1, the other auxiliary agents consist of 4 parts by weight of binding agents and 15 parts by weight of effervescent disintegrating agents, the binding agents are mixtures of polyvinyl alcohol (PVA-1788) and polyethyleneimine (Mw = 70000), and the mass ratio is 4.2:1 (a 0.7wt% aqueous solution thereof has a shear viscosity of 3.2 mPas); the effervescent disintegrating agent consists of 2 parts by weight of acid and 4.5 parts by weight of alkali metal salt, wherein the acid is a mixture of citric acid and tartaric acid, the volume ratio is 1:1, and the alkali metal salt is sodium bicarbonate.
The preparation method of the abamectin foam formulation comprises the following steps: drying the carrier component for 1.5 hours at 95 ℃, mixing the carrier component with abamectin, then placing the mixed mixture in a high-pressure mixing kettle, adjusting the pressure of the mixing kettle to 5.2MPa, adding a penetrating agent (cyclopentane), maintaining the pressure at 45 ℃ for 60min, then releasing the pressure, recovering the penetrating agent, taking out the mixture, drying the mixture at 60 ℃ for 30min, mixing the mixture with a wetting agent, a dispersing agent and a synergist, carrying out high-speed universal grinding until the fineness is about 400 meshes, stirring and mixing the obtained powder with diatomite to obtain powder, stirring and mixing the obtained powder with an adhesive and an effervescent disintegrating agent uniformly, and granulating to obtain the finished product.
Example 3
This example provides a high stability avermectin composition, which includes 3.6wt% avermectin, 4wt% carrier, 4.5wt% adjuvant, and the balance diatomaceous earth; the diatomite is Celite610 of France Yirui stone, the average particle size of the carrier is 200nm, the carrier is a mixed mixture of white carbon black and modified organic bentonite, the mass ratio is 3:2, the modified organic bentonite is a mixture of cefradine modified bentonite and octadecylamine modified bentonite, and the mass ratio is 1.5; the auxiliary agent comprises 2wt% of dispersing agent, 1.5wt% of wetting agent and 1wt% of synergist, the dispersing agent is HMK-D1003 of Moke chemical technology Co., ltd, beijing Han, the wetting agent is organosilicon QS-302-NP50 of Sancheng New Material Co., ltd, jiangxi, and the synergist is epoxidized soybean oil.
The embodiment also provides an abamectin foam formulation, which comprises the high-stability abamectin composition and other auxiliary agents, wherein the mass ratio of the abamectin composition to the other auxiliary agents is 1:1, the other auxiliary agents consist of 4 parts by weight of adhesive and 15 parts by weight of effervescent disintegrating agent, and the adhesive is polyvinylpyrrolidone (PVP, the molecular weight is 369000, and the shear viscosity of 0.7wt% aqueous solution of the polyvinylpyrrolidone is 1.3mPa & s); the effervescent disintegrating agent consists of 2 parts by weight of acid and 4.5 parts by weight of alkali metal salt, wherein the acid is a mixture of citric acid and tartaric acid, the volume ratio is 1:1, and the alkali metal salt is sodium bicarbonate.
The preparation method of the abamectin bubble formulation comprises the following steps: drying the carrier component for 1.5 hours at 95 ℃, mixing the carrier component with abamectin, then placing the mixed mixture in a high-pressure mixing kettle, adjusting the pressure of the mixing kettle to 5.2MPa, adding a penetrating agent (cyclopentane), maintaining the pressure at 45 ℃ for 60min, then releasing the pressure, recovering the penetrating agent, taking out the mixture, drying the mixture at 60 ℃ for 30min, mixing the mixture with a wetting agent, a dispersing agent and a synergist, carrying out high-speed universal grinding until the fineness is about 400 meshes, stirring and mixing the obtained powder with diatomite to obtain powder, stirring and mixing the obtained powder with an adhesive and an effervescent disintegrating agent uniformly, and granulating to obtain the finished product.
Example 4
This example provides a high stability avermectin composition, which includes 3.6wt% avermectin, 4wt% carrier, 4.5wt% adjuvant, and the balance diatomaceous earth; the diatomite is Celite610 of France Yirui stone, the average particle size of the carrier is 200nm, the carrier is a mixed mixture of white carbon black and modified organic bentonite, the mass ratio is 3:2, the modified organic bentonite is a mixture of cefradine modified bentonite and octadecylamine modified bentonite, and the mass ratio is 1.5; the auxiliary agent comprises 2wt% of dispersing agent, 1.5wt% of wetting agent and 1wt% of synergist, the dispersing agent is HMK-D1003 of Moke chemical technology Co., ltd, beijing Han, the wetting agent is organosilicon QS-302-NP50 of Sancheng New Material Co., ltd, jiangxi, and the synergist is epoxidized soybean oil.
The embodiment also provides an abamectin foam formulation, which comprises the high-stability abamectin composition and other auxiliary agents in a mass ratio of 1:1, wherein the other auxiliary agents consist of 4 parts by weight of a binder and 15 parts by weight of an effervescent disintegrating agent, the binder is a mixture of polyvinyl alcohol (PVA-1788) and polyethyleneimine (Mw = 70000), and the mass ratio is 4.2:1 (a 0.7wt% aqueous solution thereof has a shear viscosity of 3.2 mPas); the effervescent disintegrating agent consists of 2 weight parts of acid and 4.5 weight parts of alkali metal salt, wherein the acid is a mixture of citric acid and tartaric acid, the volume ratio is 1:1, and the alkali metal salt is sodium bicarbonate.
The preparation method of the abamectin bubble formulation comprises the following steps: drying the carrier component for 1.5 hours at 95 ℃, mixing the carrier component with the abamectin, then mixing the mixed mixture with the wetting agent, the dispersing agent and the synergist component, carrying out high-speed universal grinding until the fineness is about 400 meshes, stirring and mixing the obtained powder with the diatomite to obtain powder, then stirring and mixing the obtained powder with the adhesive and the effervescent disintegration agent uniformly, and granulating to obtain the abamectin benzoate effervescent tablet.
Example 5
This example provides a high stability avermectin composition, which includes 3.6wt% avermectin, 4wt% carrier, 4.5wt% adjuvant, and the balance diatomaceous earth; the diatomite is Celite610 of France Yirui stone, the average grain diameter of the carrier is 200nm, the carrier is a mixed mixture of white carbon black and modified organic bentonite, the mass ratio is 3:2, the modified organic bentonite is a mixture of cefadrine modified bentonite and octadecyl amine modified bentonite, and the mass ratio is 1.5; the auxiliary agent comprises 2wt% of dispersing agent, 1.5wt% of wetting agent and 1wt% of synergist, the dispersing agent is HMK-D1003 of Moke chemical technology Co., ltd, beijing Han, the wetting agent is organosilicon QS-302-NP50 of Sanchen materials Co., ltd, jiangxi Tian, the synergist is epoxidized soybean oil.
The embodiment also provides an abamectin foam formulation, which comprises the high-stability abamectin composition and other auxiliary agents in a mass ratio of 1:1, wherein the other auxiliary agents consist of 4 parts by weight of adhesive and 15 parts by weight of effervescent disintegrating agent, and the adhesive is polyvinyl alcohol (PVA-1788); the effervescent disintegrating agent consists of 2 parts by weight of acid and 4.5 parts by weight of alkali metal salt, wherein the acid is a mixture of citric acid and tartaric acid, the volume ratio is 1:1, and the alkali metal salt is sodium bicarbonate.
The preparation method of the abamectin bubble formulation comprises the following steps: drying the carrier component for 1.5 hours at 95 ℃, mixing the carrier component with abamectin, then placing the mixed mixture in a high-pressure mixing kettle, adjusting the pressure of the mixing kettle to 5.2MPa, adding a penetrating agent (cyclopentane), maintaining the pressure at 45 ℃ for 60min, then releasing the pressure, recovering the penetrating agent, taking out the mixture, drying the mixture at 60 ℃ for 30min, mixing the mixture with a wetting agent, a dispersing agent and a synergist, carrying out high-speed universal grinding until the fineness is about 400 meshes, stirring and mixing the obtained powder with diatomite to obtain powder, stirring and mixing the obtained powder with an adhesive and an effervescent disintegrating agent uniformly, and granulating to obtain the finished product.
Performance testing
The applicant prepared the samples of the above examples as 100-fold dilutions and then sprayed them from a height of around 2m using a spray head model ST110-03 at a spray pressure of 0.4MPa and tested the particle sizes D50 and D90 of the sprayed droplets by a conical spray head droplet size analyzer, where D50 is recorded as a at 140-150 μm, B at less than 140 μm (not including 140 μm), C at 150-160 μm (not including the end points) and D at 160 μm above. Where D90 is recorded as A at 210-220 μm, B less than 210 μm, C at 220-235 μm, and D above 235 μm (inclusive).
In addition, during the preparation process of the preparation, the flowability of the powder is observed and classified into 1 to 3 grades according to whether the flowability of the powder is good, whether the powder is bonded and the like, wherein the flowability of the grade 1 is the best, and the flowability of the grade 3 is the worst. In addition, carry out the spraying two days according to above-mentioned spraying mode to observe whether the shower nozzle blocks up, if take place to block up then twist off the shower nozzle, the shower nozzle is washed to the water, washes away the jam and installs the shower nozzle once more and carry out the spraying, wherein according to what of shower nozzle jam number of times carries out spraying efficiency's good or bad, 1 level is for not appearing blockking up, 2 level is for appearing 1 or 2 times, 3 levels are for appearing 3 times and above. The results of the above tests are shown in table 1 below.
TABLE 1
| D50/μm | D90/μm | Fluidity of the resin | Efficiency of spraying | |
| Example 1 | A | A | Level 1 | Level 1 |
| Example 2 | C | A | Stage 2 | Stage 2 |
| Example 3 | B | B | Level 1 | Stage 2 |
| Example 4 | D | C | Grade 3 | Grade 3 |
| Example 5 | A | C | Stage 2 | Stage 2 |
From the above experimental results, it can be seen that the present invention has excellent stability, good fluidity when preparing dosage forms, and easy flow from the storage bin to the packaging bag and then from the packaging bag to the sprayer for preparation. Moreover, the preparation of this application is high in spraying in-process stability, is difficult to appear unstable phenomena such as shower nozzle jam.
Claims (10)
1. The high-stability abamectin composition is characterized by comprising 0.1-10 wt% of abamectin, 1-10 wt% of carrier, 0.2-10 wt% of auxiliary agent and the balance of diatomite; the carrier is selected from one or more of talcum powder, modified organic bentonite, white carbon black, kaolin and montmorillonite.
2. The high-stability abamectin composition of claim 1, wherein the modified organic bentonite is at least one selected from the group consisting of cetyl trimethylammonium salt modified bentonite, ceftazidime modified bentonite, octadecyl trimethylammonium salt modified bentonite and octadecyl amine modified bentonite.
3. The high-stability abamectin composition of claim 2, wherein the particle size of the carrier is 80-500 nm.
4. The high-stability abamectin composition of claim 1, wherein said adjuvant comprises at least one of a dispersant, a wetting agent and a synergist; the synergist comprises vegetable oil.
5. An abamectin formulation characterized in that it comprises a high stability abamectin composition according to any one of claims 1 to 4, other adjuvants; the content of the abamectin in the preparation is 0.1-8 wt%.
6. The abamectin formulation according to claim 5, wherein the formulation comprises wettable powder, water dispersible granules and effervescent granules.
7. The abamectin formulation of claim 6, wherein when the formulation is in the form of effervescent granules, the other adjuvants comprise a binder and an effervescent disintegrant; the adhesive is a water-soluble high polymer material.
8. The avermectin preparation according to claim 7, wherein the water-soluble high molecular material is selected from one or more of polyoxyethylene-polyoxypropylene block copolymer, polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol, acrylic acid homopolymer, sodium carboxymethylcellulose and polyethyleneimine.
9. The abamectin formulation of claim 7, wherein when the concentration of the water-soluble polymer material in water is 0.1 to 1.5wt%, the shear viscosity of the aqueous solution thereof is 1.0 to 15 mPa-s.
10. An abamectin formulation as claimed in any one of claims 4 to 9, having a droplet size D50 of 120 to 190 μm at a spray pressure of 0.10 to 0.55 MPa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111041332.0A CN115211430B (en) | 2021-09-07 | 2021-09-07 | High-stability avermectin composition and preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111041332.0A CN115211430B (en) | 2021-09-07 | 2021-09-07 | High-stability avermectin composition and preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115211430A true CN115211430A (en) | 2022-10-21 |
| CN115211430B CN115211430B (en) | 2024-03-29 |
Family
ID=83606926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111041332.0A Active CN115211430B (en) | 2021-09-07 | 2021-09-07 | High-stability avermectin composition and preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115211430B (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001091555A2 (en) * | 2000-05-26 | 2001-12-06 | The Procter & Gamble Company | Soap based pesticides |
| CN1679392A (en) * | 2004-12-08 | 2005-10-12 | 西北农林科技大学无公害农药研究服务中心 | Preparation method of pesticide water dispersible soft particles |
| CN1977601A (en) * | 2005-12-01 | 2007-06-13 | 北京化工大学 | Avermectins long-effective slow-release wetable powder preparation and preparing method |
| CN101142913A (en) * | 2007-11-02 | 2008-03-19 | 中国农业科学院植物保护研究所 | Avermectin nanometer medicine-carried system with slow-releasing and controlled-releasing action |
| CN104663681A (en) * | 2015-02-16 | 2015-06-03 | 武汉理工大学 | Abamectin water dispersible nano-composite granule and preparation method thereof |
| WO2018032889A1 (en) * | 2016-08-15 | 2018-02-22 | 江苏辉丰农化股份有限公司 | Insecticidal composition having synergistic effect |
| CN111165481A (en) * | 2020-02-24 | 2020-05-19 | 本生(惠州)生物技术有限公司 | Diatomite-avermectin pesticide composition with specific structure and application thereof |
| CN111202083A (en) * | 2020-02-21 | 2020-05-29 | 本生(惠州)生物技术有限公司 | Diatomite-avermectin water dispersible granule with specific structure and application thereof |
| CN111202057A (en) * | 2020-02-20 | 2020-05-29 | 本生(惠州)生物技术有限公司 | Insecticidal pesticide composition containing diatomite with special structure and application thereof |
-
2021
- 2021-09-07 CN CN202111041332.0A patent/CN115211430B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001091555A2 (en) * | 2000-05-26 | 2001-12-06 | The Procter & Gamble Company | Soap based pesticides |
| CN1679392A (en) * | 2004-12-08 | 2005-10-12 | 西北农林科技大学无公害农药研究服务中心 | Preparation method of pesticide water dispersible soft particles |
| CN1977601A (en) * | 2005-12-01 | 2007-06-13 | 北京化工大学 | Avermectins long-effective slow-release wetable powder preparation and preparing method |
| CN101142913A (en) * | 2007-11-02 | 2008-03-19 | 中国农业科学院植物保护研究所 | Avermectin nanometer medicine-carried system with slow-releasing and controlled-releasing action |
| CN104663681A (en) * | 2015-02-16 | 2015-06-03 | 武汉理工大学 | Abamectin water dispersible nano-composite granule and preparation method thereof |
| WO2018032889A1 (en) * | 2016-08-15 | 2018-02-22 | 江苏辉丰农化股份有限公司 | Insecticidal composition having synergistic effect |
| CN111202057A (en) * | 2020-02-20 | 2020-05-29 | 本生(惠州)生物技术有限公司 | Insecticidal pesticide composition containing diatomite with special structure and application thereof |
| CN111202083A (en) * | 2020-02-21 | 2020-05-29 | 本生(惠州)生物技术有限公司 | Diatomite-avermectin water dispersible granule with specific structure and application thereof |
| CN111165481A (en) * | 2020-02-24 | 2020-05-19 | 本生(惠州)生物技术有限公司 | Diatomite-avermectin pesticide composition with specific structure and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115211430B (en) | 2024-03-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69810900T2 (en) | AGROCHEMICAL COMPOSITIONS OF SURFACE-ACTIVE COMPOUNDS | |
| EP2299828B1 (en) | Low use rate agrochemical adjuvant composition with good hydration properties comprising a guar, diammonium hydrogen phosphate and sodium carbonate | |
| JPH07503019A (en) | Water-dispersible granules of liquid pesticides | |
| CN101112195A (en) | Avermectin micro-emulsion and method for preparing the same | |
| US20150245606A1 (en) | Effervescent tablet for spray drift reduction and method of use | |
| CN115211430A (en) | High-stability abamectin composition and preparation | |
| CN111165481A (en) | Diatomite-avermectin pesticide composition with specific structure and application thereof | |
| CN109479879A (en) | A kind of agent for removing grass in paddy field floating particle agent and preparation method thereof | |
| JPH06510767A (en) | Method for manufacturing herbicide granular products | |
| US20240114901A1 (en) | Multifunctional agricultural adjuvant compositions | |
| CA2211996A1 (en) | Pesticidal granules containing fertilizer and surfactant | |
| CN111345294A (en) | Butylbenzone-ethyl water dispersible granule and preparation method thereof | |
| CN107006459B (en) | Mollusk control water dispersible granule and preparation method thereof | |
| CN104663681A (en) | Abamectin water dispersible nano-composite granule and preparation method thereof | |
| CN105050395A (en) | A novel aqueous suspoemulsion and a process for preparing the same | |
| JP6441282B2 (en) | Agro-horticultural wettable powder with improved physicochemical properties | |
| CN110621156B (en) | Use of N-alkylglucamides for reducing drift when applying plant treatment agents containing glufosinate | |
| CN106376552A (en) | Pyrazosulfuron water dispersible granule | |
| CN1736197A (en) | Water soluble granule of emamection benaoate and preparation method thereof | |
| CN113854311B (en) | Synergistic weeding composition and preparation and application thereof | |
| JP6726447B2 (en) | Aqueous pesticide composition | |
| JP6068853B2 (en) | Agro-horticultural wettable powder with improved physicochemical properties | |
| CN111213635B (en) | Composition containing bifenazate and hexythiazox | |
| JPH05155706A (en) | Agricultural chemical composition | |
| CN105028445A (en) | Herbicide composition and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20240304 Address after: 516100 Dalong, Luangang Village, Shiwan Town, Boluo County, Huizhou City, Guangdong Province Applicant after: Benson (Huizhou) Biotechnology Co.,Ltd. Country or region after: China Address before: 541000 Baba Factory, Lingchuan Town, Lingchuan County, Guilin City, Guangxi Zhuang Autonomous Region (workshop on the first floor of the original feed factory of Guilin Guikai Biotechnology Co., Ltd.) Applicant before: Guangxi Yicai Agricultural Development Co.,Ltd. Country or region before: China |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |