CN114191514B

CN114191514B - Traditional Chinese medicine composition for preventing and treating phlegm-damp type obesity

Info

Publication number: CN114191514B
Application number: CN202010984371.3A
Authority: CN
Inventors: 田昕; 杨傲然
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-09-18
Filing date: 2020-09-18
Publication date: 2023-08-01
Anticipated expiration: 2040-09-18
Also published as: CN114191514A

Abstract

The invention provides a traditional Chinese medicine composition for preventing and treating phlegm-damp type obesity. The traditional Chinese medicine comprises the following traditional Chinese medicine raw materials in parts by weight: 20 parts of astragalus membranaceus, 30 parts of lotus leaves, 15 parts of bighead atractylodes rhizome, 30 parts of coix seeds, 15 parts of rhizoma atractylodis, 15 parts of dried orange peel, 15 parts of semen cassiae, 30 parts of hawthorn, 15 parts of corn silk, 3 parts of cinnamon, 15 parts of herba lycopi and 10 parts of honey-fried licorice roots. The prescription of the invention is composed of 12 traditional Chinese medicines, takes astragalus and lotus leaf as monarch drugs, and has the functions of tonifying qi, raising yang, resolving dampness and promoting diuresis; the bighead atractylodes rhizome, the coix seed, the rhizoma atractylodis and the dried orange peel are taken as ministerial drugs to assist the monarch drugs in strengthening spleen and eliminating dampness, reducing phlegm and eliminating dampness; semen cassiae and corn silk are used as adjuvants, diuresis is achieved, swelling is achieved, intestines are moistened, constipation is relieved, the warm dryness of monarch and minister drugs is relieved, and the semen cassiae is beneficial to discharging water dampness and turbid phlegm out of the body, a small amount of cinnamon is used as an adjuvant drug, so that the semen cassiae can be used as an internal heat-inducing component, the channels and collaterals are warmed, the viscera functions are enhanced, metabolism is promoted, and hawthorn and herba lycopi are used as adjuvant drugs, so that the effects of activating blood and dissolving stasis are achieved, and Li Shuijiang turbid urine is achieved; prepared licorice root, radix Glycyrrhizae Praeparata is used as a guiding drug for replenishing qi to invigorate the spleen and harmonizing the drugs.

Description

Traditional Chinese medicine composition for preventing and treating phlegm-damp type obesity

Technical Field

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating phlegm-damp type obesity.

Background

With the increase of living standard, the number of obese people is increased, and the worldwide death caused by obesity is over 400 ten thousand only in 2015. The world health organization has defined overweight, obesity as a chronic disease. In China, the overweight and obese people are over 3 hundred million people, and the weight reduction is not only for beauty, but also for physical health.

Obese people are prone to metabolic disease. Metabolic syndrome, which is a complex group of metabolic disorder syndrome that easily causes critical diseases such as diabetes, cardiovascular and cerebrovascular diseases, and the like in recent years, is metabolic disorder of substances such as protein, fat, carbohydrate and the like of human bodies. Diseases include obesity, hyperglycemia, hypertension, dyslipidemia, hyperuricemia, fatty liver, hyperinsulinemia, etc., and these metabolic disorders are the pathological basis of cardiovascular and cerebrovascular pathologies and diabetes. It is now believed that a common cause of these common and frequently occurring diseases is obesity, particularly central obesity, which can cause a variety of serious diseases, including even certain cancers.

Fat people, especially those with abdominal obesity, have more fat storage in the body, are more likely to be dyslipidaemia than ordinary people, and excessive lipid is deposited in the wall of the coronary artery, so that the lumen is narrow and hardened, coronary heart disease and angina pectoris are easy to occur frequently, and cerebral hemorrhage is more likely to be caused under the action of hypertension. Obese people are prone to hypertension, and the incidence rate of hypertension is 50% higher than that of non-obese people in middle-aged and above. In addition, due to the influence of fat, the heart of obese people is easy to be hypertrophic, venous blood backflow is slowed down, and varicose veins are easy to be caused. Obesity also tends to thicken chest wall and abdominal fat, reducing lung capacity and affecting the normal ventilation function of the lungs.

One of 24 years medical studies in sweden reported that female obesity was not negligible, 60% overweight women showed a decline in mental performance with each increase in fat of 1kg. Obese people will produce excess hormone cortisone in the body, which can cause brain tissue damage and cause dementia in elderly women. For some pregnant women, obesity not only increases the difficulty of conception, but also increases the risk of fertility. Mother's obesity, her fetus is prone to premature birth, congenital malformation, giant fetus, perinatal death, etc., and may also increase the probability of childhood obesity.

In addition, obesity can cause physiological diseases such as fatty liver, gall-stone, gout and the like, and psychological problems such as spelt, anxiety, depression and the like can easily occur due to excessive swelling, and even the obesity can develop into social disorder, self-riot, sexual intercourse autism and the like.

Because the consequences of obesity are related to multi-organ, multi-system lesions. Modern medicine is finer in branch of science, and can only be treated by chemical medicines in branch of science, if the lipid regulating medicines, the hypoglycemic medicines, the antihypertensive medicines and other symptomatic western medicines are comprehensively applied, the liver and kidney functions of patients are affected by the combined medicines of multiple varieties. However, besides being unsightly, many obese patients have physical conditions that have not been treated with drugs to the extent necessary, and before the disease has progressed, they can be said to be non-medicated and edible and non-medicated. At this time, the special features of the traditional medicine are exerted.

In recent years, traditional Chinese medicine is increasingly valued by people, thousands of years of Chinese medicine culture is also increasingly deepened into the heart, and the concepts of 'disease prevention before disease prevention' and 'disease prevention change' of Chinese medicine more cover the main ideas of preventive medicine in the theoretical system of modern medicine, and are the essence of Chinese medicine culture. Under the condition that the syndrome of the obesity, which is fuzzy in branch and is not limited well, is difficult to belonged to, the 'integral concept' of the traditional Chinese medicine provides various theoretical basis for the recognition of the obesity; the "treatment based on syndrome differentiation" in traditional Chinese medicine is the fundamental way for solving obesity; the best weapon for preventing and treating obesity is the best compatibility of various choices and prescriptions of traditional Chinese medicines.

Because obesity is highly developed in recent years, modern medicine does not explicitly classify the type of obesity, treats secondary diseases caused by obesity, and does not systematically classify and guide administration of the obesity. The commonly used weight-reducing medicines are mainly divided into the following categories: firstly, the appetite suppressant type weight-losing medicine has the effect of exciting central nervous system, and can reduce appetite by exciting satiety central to generate boredom psychology, so as to achieve the purpose of diet control, and the side effect of the medicine is that insomnia and tension can be caused, long-term taking can cause addiction, and the medicine cannot be taken at night and cannot be taken for a long time. The second is a gastrointestinal lipase inhibitor type weight-losing medicine, which can achieve the purpose of weight reduction by directly blocking the absorption of fat in food by human bodies, has the advantages of no entry of active ingredients into blood and small side effects, is only approved by one country at present, can be used for losing weight, and can cause adverse reactions such as gastrointestinal discomfort, respiratory tract infection and the like only by taking the medicine. The third class is hormone slimming medicine, which can improve metabolism of human body and increase decomposition and consumption of fat, thereby achieving the purpose of weight reduction. However, if the medicine is taken excessively, palpitation, insomnia, heat and sweating will be caused, and heart premature contraction and angina pectoris will occur in severe cases, so the medicine should be taken carefully.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for preventing and treating phlegm-damp type obesity.

The invention provides a traditional Chinese medicine composition for preventing and treating phlegm-damp type obesity, which comprises the following traditional Chinese medicine raw materials in parts by weight: 20 parts of astragalus, 15-45 parts of lotus leaf, 10-25 parts of bighead atractylodes rhizome, 15-45 parts of coix seed, 10-25 parts of rhizoma atractylodis and 10-30 parts of dried orange peel.

The traditional Chinese medicine composition for preventing and treating the phlegm-damp type obesity provided by the invention can further comprise: the weight portions of the traditional Chinese medicine composition are 5-30 portions of cassia seed, 10-30 portions of corn silk, 1-9 portions of cinnamon, 15-45 portions of hawthorn and 10-30 portions of herba lycopi.

The traditional Chinese medicine composition for preventing and treating the phlegm-damp type obesity provided by the invention can further comprise the following components: 5-15 parts of honey-fried licorice root.

Specifically, the traditional Chinese medicine composition for preventing and treating the phlegm-damp type obesity comprises the following traditional Chinese medicine raw materials in parts by weight: 20 parts of astragalus membranaceus, 20-40 parts of lotus leaves, 12-20 parts of bighead atractylodes rhizome, 20-40 parts of coix seeds, 12-20 parts of rhizoma atractylodis, 12-25 parts of dried orange peel, 10-25 parts of semen cassiae, 12-20 parts of corn silk, 2-5 parts of cinnamon, 20-40 parts of hawthorn, 10-20 parts of herba lycopi and 8-12 parts of honey-fried licorice roots.

More specifically, the traditional Chinese medicine composition for preventing and treating the phlegm-damp type obesity comprises the following traditional Chinese medicine raw materials in parts by weight: 20 parts of astragalus membranaceus, 30 parts of lotus leaves, 15 parts of bighead atractylodes rhizome, 30 parts of coix seeds, 15 parts of rhizoma atractylodis, 15 parts of dried orange peel, 15 parts of semen cassiae, 30 parts of hawthorn, 15 parts of corn silk, 3 parts of cinnamon, 15 parts of herba lycopi and 10 parts of honey-fried licorice roots.

The traditional Chinese medicine composition for preventing and treating the phlegm-damp type obesity is prepared by the following method: mixing all the Chinese medicinal materials, decocting in water, and collecting decoction.

The invention is clearly classified on the basis of recognizing the characteristic expression of obese people, is favorable for identifying types and accurately taking medicines, is exactly the embodiment of the core concept of the traditional Chinese medicine 'diagnosis and treatment', can better reduce a series of diseases caused by obesity, can adjust the variety and dosage of medicines at any time according to the change of bodies, and also follows the principle of the traditional Chinese medicine 'arrangement concept'.

The inventors of the present invention have engaged in first-line clinical work for 17 years and have accumulated a lot of experience in the clinical treatment of obesity. Through theoretical practice for many years, obesity is classified into phlegm-damp type and damp-heat type, and two visual names are respectively given to the obesity: water fatty (phlegm-damp type) and oil fatty (damp-heat type). The damp-heat type can be classified into spleen and stomach damp-heat and liver and gallbladder damp-heat according to viscera differentiation.

Because the basis for preventing and treating obesity is the differentiation of traditional Chinese medicine, the two types are very different, and are summarized as follows:

the phlegm-dampness (water fatty) mainly manifests as: obesity, listlessness debilitation, dizziness, palpation, eyelid swelling, heavy lower limbs or edema. Sticky and greasy in the mouth, no desire to drink water, poor appetite, excessive phlegm or cough. The excrement is more frequently daily, is not formed, and is immediately dispersed after being washed with water. A pale and fat tongue with slippery or white and greasy coating and a tooth trace on the side. The pulse is soft and slippery.

Damp-heat type (fatty oil) mainly shows: obesity, debilitation, dizziness, eyelid swelling or conjunctival congestion, sticky and uncomfortable mouth, thirst, excessive appetite, gingival swelling and pain or tooth brushing bleeding, and yellow and colorful phlegm. Greasy head and face, large pores and dribbling sweat after activity. The feces are viscous and not clean; or irritability, excessive ocular secretions, bitter and dry mouth. A red tongue with yellow and greasy coating. The soft-superficial pulse or the wiry-slippery pulse.

Aiming at the characteristics of phlegm-damp type obesity (water-fat), the inventor develops a traditional Chinese medicine composition for preventing and treating the phlegm-damp type obesity, and the prescription of the invention consists of 12 traditional Chinese medicines, takes astragalus and lotus leaf as monarch drugs, and has the effects of tonifying qi, raising yang, resolving dampness and promoting diuresis; the bighead atractylodes rhizome, the coix seed, the rhizoma atractylodis and the dried orange peel are taken as ministerial drugs to assist the monarch drugs in strengthening spleen and eliminating dampness, reducing phlegm and eliminating dampness; semen cassiae and corn silk are used as adjuvants, diuresis is achieved, swelling is achieved, intestines are moistened, constipation is relieved, the warm dryness of monarch and minister drugs is relieved, and the semen cassiae is beneficial to discharging water dampness and turbid phlegm out of the body, a small amount of cinnamon is used as an adjuvant drug, so that the semen cassiae can be used as an internal heat-inducing component, the channels and collaterals are warmed, the viscera functions are enhanced, metabolism is promoted, and hawthorn and herba lycopi are used as adjuvant drugs, so that the effects of activating blood and dissolving stasis are achieved, and Li Shuijiang turbid urine is achieved; prepared licorice root, radix Glycyrrhizae Praeparata is used as a guiding drug for replenishing qi to invigorate the spleen and harmonizing the drugs.

Detailed Description

The present invention will be described with reference to the following specific examples, but the present invention is not limited thereto.

The experimental methods used in the following examples are all conventional methods unless otherwise specified; the reagents, materials, etc. used in the examples described below are commercially available unless otherwise specified.

The astragalus, lotus leaf, bighead atractylodes rhizome, coix seed, rhizoma atractylodis, dried orange peel, cassia seed, hawthorn, corn silk, cinnamon, herba lycopi and honey-fried licorice root used in the invention are all traditional Chinese medicinal materials (dry products), and all meet the relevant regulations under each medicinal material item of a text of Chinese pharmacopoeia (2020 edition). Before feeding, each medicinal material object accords with the name and the quality accords with the standard through identification.

Examples

The formula comprises the following components: 20 g of astragalus membranaceus, 30 g of lotus leaves, 15 g of bighead atractylodes rhizome, 30 g of coix seeds, 15 g of rhizoma atractylodis, 15 g of dried orange peel, 15 g of semen cassiae, 30 g of hawthorn, 15 g of corn silk, 3 g of cinnamon, 15 g of herba lycopi and 10 g of honey-fried licorice root.

Clinical statistical analysis

1. Method of

80 patients with excessive phlegm dampness in the period of 2016-2018, meeting inclusion and exclusion standards, are selected and divided into a control group and a treatment group by a random digital table method, wherein each group is 40. The age of the control group is 18-60 years, and the average age is (32.91 soil 3.29), wherein 19 men and 21 women are treated; weight 74-86 kg, average weight 80.12+ -2.01 kg. The age of the treatment group is 18-59 years, and the average age is (31.44+/-3.16); 22 men and 18 women; the weight of the body is 75-85 kg, and the average weight is 80.79+/-1.98 kg. The general data of age, sex and course of the patient have no statistical significance (P > 0.05) compared with the differences.

The contrast group is prepared from traditional Chinese medicines, namely ginseng, poria cocos and bighead atractylodes rhizome pills (6 g of the same ren Tang is 12 bags), which mainly comprise ginseng, bighead atractylodes rhizome, poria cocos, chinese yam, coix seed, lotus seed, white hyacinth bean, fructus amomi, platycodon grandiflorum, liquorice and the like, and have the effects of strengthening spleen and supplementing qi, resolving phlegm and eliminating dampness;

the water-fat formulation for the treatment group: 20 g of astragalus membranaceus, 30 g of lotus leaves, 15 g of bighead atractylodes rhizome, 30 g of coix seeds, 15 g of rhizoma atractylodis, 15 g of dried orange peel, 15 g of semen cassiae, 30 g of hawthorn, 15 g of corn silk, 3 g of cinnamon, 15 g of herba lycopi and 10 g of honey-fried licorice root. One pair of the Chinese herbal medicines is decocted to 500ml with water every day, and the Chinese herbal medicines are orally taken for three times, and four weeks are one observation period.

2. Diagnostic criteria

Western diagnostic criteria: adopts Chinese adult overweight and obesity prevention control guidelines issued by the department of health disease control in 2006 as standard, namely Body Mass Index (BMI) is more than or equal to 24kg/m ² Is overweight, and the BMI is more than or equal to 28kg/m ² Those diagnosed with obesity, those with secondary obesity removed, and those diagnosed with simple obesity. B (B)MI = weight (kg)/height ² (m ² )。

Diagnostic criteria for Chinese medical science syndrome: the syndrome of traditional Chinese medicine is determined according to the guidelines of clinical research on new traditional Chinese medicine. The symptoms are as follows: obesity, listlessness debilitation, dizziness, palpation, eyelid swelling, heavy lower limbs or edema. Sticky and greasy in the mouth, no desire to drink water, poor appetite, excessive phlegm or cough. The excrement is more frequently daily, is not formed, and is immediately dispersed after being washed with water. A pale and fat tongue with slippery or white and greasy coating and a tooth trace on the side. The pulse is soft and slippery. More than half of the symptoms are consistent, and the tongue pulse is consistent, so that the syndrome of excessive phlegm-dampness can be distinguished.

3. Inclusion criteria and exclusion criteria

Inclusion criteria: (1) meets the Western diagnosis standard and the Chinese medicine dialectical standard; (2) age is 18 years less than or equal to 60 years less than or equal to 18 years, and the sex is unlimited; (3) no treatment such as lipid regulation and weight loss is carried out within 1 month; (4) abdominal obesity.

Exclusion criteria: (1) those who do not meet inclusion criteria; (2) patients with severe liver, kidney, heart dysfunction or critical illness; (3) the application of traditional Chinese medicine, western medicine or Chinese patent medicine possibly affecting experimental results in the last 3 months; (4) allergic to proteins; (5) patients suffering from severe psychotic disorders; (6) poor clotting function, combined with infection and hemorrhage; (7) pregnant and lactating women.

4. Therapeutic method

Basic treatment: the two groups of patients were on a reasonable diet during the observation period, and were less on fried, sweet, high cholesterol, high fat, high calorie foods, 19 per night: no food was taken after 00 o' clock. During the administration period, the user does not need to do intense exercise, and the daily exercise form is mainly walking. Energy (kcal) =ideal body weight (kg) × (20-25) as daily as possible, energy supply not less than 1000 kcal/day, wherein fat accounts for 20% -30%, protein accounts for 15% -20%, and carbohydrate accounts for 40% -55%. The water intake was 1500 ml/day. Three meals are regularly and quantitatively eaten, and each meal is seven and one minute full, so that sufficient sleep is ensured.

5 observation of curative effect

And (3) observing the indexes: body weight, body mass index, and changes before and after waist circumference treatment.

Western medicine efficacy evaluation criteria: reference is made to the obesity efficacy rating criteria established by the second national institute of advanced combined with the national institute of obesity study. It is classified into effective, effective and ineffective according to the degree of weight loss and waist circumference reduction. The obvious effect is as follows: the weight is reduced by more than or equal to 5-10 kg, and the waistline is reduced by more than or equal to 6-10 cm; the method is effective in that: the weight is reduced by 3-5 kg, and the waistline is reduced by 4-6 cm; the invalidation is as follows: weight loss <3kg, waist circumference loss <4cm.

6 statistical method

Statistical processing was performed using SPSS20.0 software. The metering data accords with normal distribution and is expressed by mean ± standard deviation (x ± s), the comparison before and after the group uses paired t test, and the comparison between the groups uses independent sample f test; count data comparison uses X ² And (5) checking. With P<0.05 is a statistically significant standard for the differences.

Results 7 results

The total effective rate of the treatment group is higher than that of the control group by comparing the curative effect of the two groups of patients, and the difference of the two groups of comparison has statistical significance (P < 0.05), and is shown in Table 1.

Table 1 compares the efficacy of two groups of patients [ example (%)

The body weight, body mass index, and waist circumference data of the two groups of patients are compared and detailed in Table 2.

Table 2 compares body weight, body Mass index, waist circumference before and after treatment for two groups of patients

The contrast difference between the control group and the treated group body weight, body mass index and waistline group before treatment has no statistical significance (P > 0.05).

After treatment # the body weight, body mass index and waist circumference of the control group and the treatment group were significantly reduced (P < 0.05) compared to the same group before treatment. The body weight, body mass index and waistline of the treatment group are lower than those of the control group, and the comparison difference has statistical significance (P < 0.05).

Claims

1. A traditional Chinese medicine composition for preventing and treating phlegm-damp type obesity is prepared from the following traditional Chinese medicine raw materials in parts by weight:

20 parts of astragalus membranaceus, 30 parts of lotus leaves, 15 parts of bighead atractylodes rhizome, 30 parts of coix seeds, 15 parts of rhizoma atractylodis, 15 parts of dried orange peel, 15 parts of semen cassiae, 30 parts of hawthorn, 15 parts of corn silk, 3 parts of cinnamon, 15 parts of herba lycopi and 10 parts of honey-fried licorice roots.

2. A method of preparing the traditional Chinese medicine composition of claim 1, comprising: mixing the above materials, decocting in water, and making into decoction.

3. The use of the Chinese medicinal composition according to claim 1 in the preparation of a medicament for preventing and treating phlegm-dampness type obesity;

the phlegm-dampness type obesity mainly shows that: obesity, listlessness debilitation, dizziness, sleepiness, eyelid swelling, heavy lower limbs or edema; sticky and greasy in the mouth, no desire to drink water, poor appetite, excessive phlegm or cough; the excrement is more frequently daily, is not formed, and is immediately dispersed after being washed with water; a pale and fat tongue with watery or white greasy coating and teeth marks on the sides; the pulse is soft and slippery.