CN103494916B - Traditional Chinese medicine composition with effect of reducing blood sugar, as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition with effect of reducing blood sugar, as well as preparation method and application thereof Download PDFInfo
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- CN103494916B CN103494916B CN201310465427.4A CN201310465427A CN103494916B CN 103494916 B CN103494916 B CN 103494916B CN 201310465427 A CN201310465427 A CN 201310465427A CN 103494916 B CN103494916 B CN 103494916B
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Abstract
The invention discloses a traditional Chinese medicine composition with the effect of reducing blood sugar. The traditional Chinese medicine composition is prepared from the following active ingredients in parts by weight: 30-40 parts of hairy clovershrub root, 15-25 parts of motherwort herb, 8-12 parts of peach seed, 15-25 parts of dichrocephala integrifolia, 15-25 parts of immature bitter orange, 15-25 parts of Indian buead and 8-12 parts of liquorice root. The traditional Chinese medicine composition can be in the form of granules, tablets, oral liquid and capsules. The invention further discloses a preparation method of the traditional Chinese medicine composition. The preparation method comprises the following steps: adding water for decoction, concentrating, performing alcohol precipitation, performing spray-drying, and adding auxiliary materials to prepare the composition. The invention also discloses application of the traditional Chinese medicine composition to preparation of medicaments with the effect of reducing blood sugar.
Description
Technical field
The present invention relates to Chinese medicine composition, be specifically related to a kind of Chinese medicine composition with effect of lowering blood sugar and its preparation method and application.
Background technology
The metabolic disease of diabetes to be one group with hyperglycemia be feature.Hyperglycemia be then due to defect of insulin secretion or its biological agent impaired, or both have concurrently and cause.Long-standing hyperglycemia during diabetes, causes various tissue, particularly eye, kidney, heart, blood vessel, neural chronic lesion, dysfunction.The medicine of current clinical treatment 2 type is except insulin, and mainly oral antidiabetic drug, is roughly divided into sulphanylureas, biguanides, Chinese medicine preparation, other antidiabetic drugs and adjuvant drug.But its side effect of these Oral Chemicals is mainly manifested in all has certain detrimental effect to blood phase, liver function, renal function, diabetes mellitus's property cardiovascular and cerebrovascular complication can be caused, easily occur hypoglycemic reaction, irritant to gastrointestinal, generation anorexia, Nausea and vomiting are even suffered from diarrhoea.Therefore select efficient and can life-time service without any side effects, curative effect is reliable, the hypoglycemic medicine of taking convenience is badly in need of, Chinese medicine has certain curative effect for treatment diabetes, contrast Western medicine has the features such as curative effect is high, toxic and side effects is little, but the curative effect of current Chinese medicine preparation treatment diabetes is not remarkable, cannot play the advantage of TCM treatment of diabetes.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine composition with effect of lowering blood sugar and its preparation method and application.
Technical scheme: the object of the invention is by following scheme realize:
There is a Chinese medicine composition for effect of lowering blood sugar, extracted by following raw materials in part by weight medicine and be prepared from: large and red 30-40 part, Herba Leonuri 15-25 part, Semen Persicae 8-12 part, Herba Houttuyniae 15-25 part, Fructus Aurantii Immaturus 15-25 part, Poria 15-25 part and Radix Glycyrrhizae 8-12 part.
Above-mentioned a kind of Chinese medicine composition with effect of lowering blood sugar, is extracted by following raw materials in part by weight medicine and is prepared from: large and red 35 parts, Herba Leonuri 20 parts, 10 parts, Semen Persicae, Herba Houttuyniae 20 parts, Fructus Aurantii Immaturus 20 parts, 20 parts, Poria and 10 parts, Radix Glycyrrhizae.
The above-mentioned Chinese medicine composition with effect of lowering blood sugar, dosage form is granule, tablet, oral liquid, capsule.
The above-mentioned method with effect of lowering blood sugar Chinese medicine composition, preparation process is: get large and red, Herba Leonuri, Semen Persicae, Herba Houttuyniae, Fructus Aurantii Immaturus, Poria and licorice medicinal materials merge, decoct with water twice, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, add ethanol, stir, make alcohol content by volume percentage calculation reach 65-85%, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol to obtain concentrated solution, concentrated solution is added adjuvant and makes oral liquid, or by concentrated solution spraying dry, add adjuvant, make granule, tablet or capsule.
The above-mentioned preparation method with effect of lowering blood sugar Chinese medicine composition, decocting condition is: amount of water is the 8-12 times amount of medical material weight for the first time, decocts 1-2h, and second time amount of water is the 6-10 times amount of medical material weight, decocts 1-2h.
The above-mentioned preparation method with effect of lowering blood sugar Chinese medicine composition, described spray drying condition is: inlet temperature is 90-110 DEG C, and leaving air temp is 80-90 DEG C, and temperature of charge is 80-90 DEG C, and atomizing pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
The above-mentioned Chinese medicine composition with effect of lowering blood sugar is preparing the application had in effect of lowering blood sugar medicine.
Beneficial effect:
1, from theory of Chinese medical science, the diabetes traditional Chinese medical science is thought " quenching one's thirst " demonstrate,proves, and this disease of " quenching one's thirst " in Treatise on Febrile Diseases is classified as JUE YIN syndrome, Fang Zhong great and red, Herba Leonuri, Semen Persicae are invigorated blood circulation, regulate the flow of vital energy, pain relieving, are monarch drug altogether, Herba Houttuyniae heat-clearing and toxic substances removing, dampness removing, Fructus Aurantii Immaturus promoting the circulation of QI and reducing phlegm, be ministerial drug altogether, Poria invigorating the spleen and regulating the stomach, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, be adjuvant altogether, all medicines are harmonious, and play blood circulation promoting and blood stasis dispelling, clearing away heat and promoting production of body fluid, the effect of eliminating the phlegm altogether, for the treatment of diabetes.
2, Formulation of the present invention is reasonable, and compatibility is rigorous.
3, the present invention consists of natural Chinese medicine, has no side effect, low price.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, in conjunction with detailed description of the invention, the present invention is further described as follows:
According to the form below, listed weight proportion takes raw material required for the present invention, unit: g
| Large and red | Herba Leonuri | Semen Persicae | Herba Houttuyniae | Fructus Aurantii Immaturus | Poria | Radix Glycyrrhizae | |
| Embodiment 1 | 30 | 25 | 8 | 25 | 15 | 25 | 8 |
| Embodiment 2 | 35 | 20 | 10 | 20 | 20 | 20 | 10 |
| Embodiment 3 | 35 | 20 | 10 | 20 | 20 | 20 | 10 |
| Embodiment 4 | 40 | 15 | 12 | 15 | 25 | 15 | 15 |
In the present invention, large and red is the pulse family Hang Zi tip platymiscium Mao Hangzi tip, and be used as medicine with root, Herba Houttuyniae is the herb of the little Herba Houttuyniae of feverfew or chrysanthemum leaf Herba Houttuyniae, and all the other are pharmacopeia kind.
2. prepare embodiment
More than showing Raw proportioning is example, comprises the following steps:
Embodiment 1: the preparation of granule
Medical material mixing is taken by medical material consumption each in upper table, decoct with water twice, first time adds water as 8 times amount of medical material weight, decoct 1.5h, second time adds water as 6 times amount of medical material weight, decoct 1h, collecting decoction, filter, filtrate is concentrated into relative density 1.10 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 65%, stir, leave standstill 24 hours, filter, filtrate recycling ethanol is also concentrated into the concentrated solution of relative density 1.20 (65 DEG C), it is spray-dried that (condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), be ground into dry extract, then add suitable dextrin, mix homogeneously, with appropriate 80% ethanol wet, soft material processed, cross 14 mesh sieves and granulate, 70 DEG C of dryings, 60 order granulate, obtain granule.
Embodiment 2: the preparation of tablet
Medical material mixing is taken by medical material consumption each in upper table, decoct with water twice, add water as 10 times amount of medical material weight time, decoct 2h, second time adds water as 8 times amount of medical material weight, decoct 1h, collecting decoction, filter, filtrate is concentrated into relative density 1.15 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 75%, stir, leave standstill 24 hours, filter, filtrate recycling ethanol is also concentrated into the concentrated solution of relative density 1.25 (65 DEG C), it is spray-dried that (condition is inlet temperature is 120 DEG C, leaving air temp is 90 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.3 MPa, spray velocity is 7.5/s.), be ground into dry extract, then add appropriate Icing Sugar, mix homogeneously, with appropriate 80% ethanol wet, soft material processed, cross 30 mesh sieves and granulate, in 70 ~ 80 DEG C of dryings, with 60 mesh sieve granulate, tabletting, sugar coating, subpackage, outer package, censorship is qualified, obtains finished product.
Embodiment 3: the preparation of oral liquid
Medical material mixing is taken by medical material consumption each in upper table, decoct with water twice, first time adds water as 12 times amount of medical material weight, decoct 2h, second time adds water as 10 times amount of medical material weight, decoct 2h, collecting decoction, filter, filtrate is concentrated into relative density 1.20 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 85%, stir, leave standstill 24 hours, filter, filtrate recycling ethanol is also concentrated into the concentrated solution of relative density 1.30 (65 DEG C), with sucrose and propanoic acid 0.1% or sodium benzoate 0.1% ~ 0.25% etc. as antiseptic, obtain oral liquid finished product.
Embodiment 4: the preparation of capsule
Medical material mixing is taken by medical material consumption each in upper table, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 1.5h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, filter, filtrate is concentrated into relative density 1.15 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 75%, stir, leave standstill 24 hours, filter, filtrate recycling ethanol is also concentrated into the concentrated solution of relative density 1.25 (65 DEG C), it is spray-dried that (condition is inlet temperature is 120 DEG C, leaving air temp is 90 DEG C, temperature of charge is 90 DEG C, atomizing pressure is 0.4 MPa, spray velocity is 7.5/s.), be ground into dry extract, cross No. 6 sieves, reinstall No. 1 capsule finished product.
3. hypoglycemic pharmacodynamic study falls
Of the present invention have reduce blood glucose on drug composition have and significantly reduce blood glucose action and efficacy, further illustrate effect of the present invention with experiment below:
Laboratory animal: Kunming mouse (20 ± 2g) is male, and Shanghai Slac Experimental Animal Co., Ltd. provides, production licence: SCXK (Shanghai) 2007-0005.
Experimental agents: this Chinese medicine composition oral liquid, by above-mentioned oral liquid embodiment method preparation.
Take the large and red 35g of medical material, Herba Leonuri 20g, Semen Persicae 10g, Herba Houttuyniae 20g, Fructus Aurantii Immaturus 20g, Poria 20g and Radix Glycyrrhizae 10g mixes, decoct with water twice, first time adds water as 12 times amount of medical material weight, decoct 2h, second time adds water as 10 times amount of medical material weight, decoct 2h, collecting decoction, filter, filtrate is concentrated into relative density 1.20 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 85%, stir, leave standstill 24 hours, filter, filtrate recycling ethanol is also concentrated into the concentrated solution of relative density 1.30 (65 DEG C), with sucrose and propanoic acid 0.1% or sodium benzoate 0.1% ~ 0.25% etc. as antiseptic, obtain oral liquid finished product 10, specification: 10mL/ props up (being equivalent to containing crude drug 13.5g), lot number: 20120815.Diabetes pill, Guangzhou Zhongyi Medicine Industry Co., Ltd's product, lot number 20120410, specification is 30g/ bottle, 120 every bottle, and 10 is 2.5g.Dosage: according to " by the dose,equivalent ratio table of surface conversion between humans and animals ", every day, the consumption of 70 kilograms of people was 67.5g, every day every, the consumption of 20g mice was 67.5*0.0026=0.1755g, it is 13.5g that cause often props up oral liquid 10mL containing crude drug amount, namely the consumption of every mice is 0.13ml, therefore low dose of every gavage 0.1ml oral liquid is determined, middle dosage and high dose gavage 0.2ml and 0.4mL respectively, every day every, the oral liquid of 20g mouse stomach was respectively 0.135g containing crude drug amount, 0.27g, 0.54g, then press Mice Body restatement, low dosage, middle dosage and high dose are respectively 6.75g crude drug amount/kg, 13.5g crude drug amount/kg and 27g crude drug amount/kg.
Positive drug diabetes pill, Guangzhou Zhongyi Medicine Industry Co., Ltd's product, lot number 20120310, specification is 30g/ bottle, 120 every bottle, 10 is 2.5g, and patient uses generally each 10, every day 2 times, i.e. people's consumption per day 5g, being equivalent to every 20g mice consumption is 5*0.0026=0.013g, and calculate by per kilogram mice, namely positive drug group gives diabetes pill 0.65g/kg.
Instrument and reagent: alloxan (C
4h
2n
2o
4h
2o, molecular weight 160.08), blood glucose meter, full automatic biochemical apparatus, 721 spectrophotometers, microplate reader, balance.
After adaptability raises 1 day, get 10 mices at random as normal group, another 90 animal fasting 3-5 hour, survey fasting glucose, as this batch of animal basal plasma glucose value.Animal fasting subsequently 24 hours (freely drinking water), lumbar injection alloxan (using front Fresh) 130mg/kg modeling, animal fasting 5 hours after 5 days, surveys blood glucose, and blood glucose value 10 ~ 25mmol/L is hyperglycemia model success animal.
Select hyperglycemia model animal 40, by the blood sugar level grouping of fasting 3-5 hour, select 1 model control group and 4 dosage groups (between group, difference is not more than 1.1mmol/L) at random, often organize 10 animals, dosage group gives variable concentrations given the test agent, and model control group gives solvent, continuous 30 days, survey fasting blood sugar (fasting is with before experiment), more each treated animal blood glucose value and blood glucose decline percentage rate.
The effect ((X scholar D) that the present invention declines to the sugared model mice blood glucose of height
Compare * * * p < 0.001 with normal group, compare ###p < 0.001 with model group, compare with positive drug group
$p < 0.05.
Medicine of the present invention has hypoglycemic effect to hyperglycemia mice, significantly reduces, illustrate that the present invention has hypoglycemic effect with blood glucose value after model group comparative experiments.The high dose group of medicine of the present invention is compared with positive drug group, and blood glucose declines significant difference, illustrates that the effect of medicine of the present invention is better than positive drug.
Claims (6)
1. one kind has the Chinese medicine composition of effect of lowering blood sugar, it is characterized in that being extracted by following raw materials in part by weight medicine being prepared from: large and red 30-40 part, Herba Leonuri 15-25 part, Semen Persicae 8-12 part, Herba Houttuyniae 15-25 part, Fructus Aurantii Immaturus 15-25 part, Poria 15-25 part and Radix Glycyrrhizae 8-12 part, preparation method step is: get large and red, Herba Leonuri, Semen Persicae, Herba Houttuyniae, Fructus Aurantii Immaturus, Poria and licorice medicinal materials merge, decoct with water twice, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, add ethanol, stir, make alcohol content by volume percentage calculation reach 65-85%, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol to obtain concentrated solution, concentrated solution is added adjuvant and makes oral liquid, or by concentrated solution spraying dry, add adjuvant, make granule, tablet or capsule.
2. a kind of Chinese medicine composition with effect of lowering blood sugar as claimed in claim 1, is characterized in that being extracted by following raw materials in part by weight medicine being prepared from: large and red 35 parts, Herba Leonuri 20 parts, 10 parts, Semen Persicae, Herba Houttuyniae 20 parts, Fructus Aurantii Immaturus 20 parts, 20 parts, Poria and 10 parts, Radix Glycyrrhizae.
3. there is the Chinese medicine composition of effect of lowering blood sugar as claimed in claim 1 or 2, it is characterized in that dosage form is granule, tablet, oral liquid, capsule.
4. there is the preparation method of the Chinese medicine composition of effect of lowering blood sugar as claimed in claim 1, it is characterized in that, decocting condition is: amount of water is the 8-12 times amount of medical material weight for the first time, decocts 1-2h, second time amount of water is the 6-10 times amount of medical material weight, decocts 1-2h.
5. there is the preparation method of the Chinese medicine composition of effect of lowering blood sugar as claimed in claim 1, it is characterized in that, described spray drying condition is: inlet temperature is 90-110 DEG C, leaving air temp is 80-90 DEG C, temperature of charge is 80-90 DEG C, atomizing pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
6. the Chinese medicine composition as claimed in claim 1 or 2 with effect of lowering blood sugar is preparing the application had in effect of lowering blood sugar medicine.
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| CN104146255B (en) * | 2014-08-18 | 2016-02-24 | 于法周 | A kind ofly be applicable to chewable tablets of type II diabetes people and preparation method thereof |
| CN104800758A (en) * | 2015-04-30 | 2015-07-29 | 淄博齐鼎立专利信息咨询有限公司 | Traditional Chinese medicine for reducing blood glucose |
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| CN101642547A (en) * | 2009-06-14 | 2010-02-10 | 李承平 | Chinese patent medicine for treating diabetes |
| CN101715850A (en) * | 2009-11-13 | 2010-06-02 | 中国绿色食品实业有限公司 | Health-preserving tea capable of preventing and treating diabetes mellitus and preparation method thereof |
| CN102047997A (en) * | 2009-11-10 | 2011-05-11 | 上海市新文达生物科技有限公司 | Wuyi Mountain rock tea extract, and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101642547A (en) * | 2009-06-14 | 2010-02-10 | 李承平 | Chinese patent medicine for treating diabetes |
| CN102047997A (en) * | 2009-11-10 | 2011-05-11 | 上海市新文达生物科技有限公司 | Wuyi Mountain rock tea extract, and preparation method and application thereof |
| CN101715850A (en) * | 2009-11-13 | 2010-06-02 | 中国绿色食品实业有限公司 | Health-preserving tea capable of preventing and treating diabetes mellitus and preparation method thereof |
Non-Patent Citations (2)
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| 崔同寅.锈钉子.《全国重名易混中药鉴别手册》.中国医药科技出版社,1992,(第1版),第87页. * |
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