CN101375996B - Brain-tonifying and intelligence-raising formulation and preparation method thereof - Google Patents
Brain-tonifying and intelligence-raising formulation and preparation method thereof Download PDFInfo
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- CN101375996B CN101375996B CN2008101519180A CN200810151918A CN101375996B CN 101375996 B CN101375996 B CN 101375996B CN 2008101519180 A CN2008101519180 A CN 2008101519180A CN 200810151918 A CN200810151918 A CN 200810151918A CN 101375996 B CN101375996 B CN 101375996B
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Abstract
The invention relates to a preparation with effects of strengthening brain and improving intelligence, and a preparation method thereof. The preparation is prepared from the following materials (by weight part): Lycium barbarum fruit 130-200, processed Polygonum multiflorum 100-150, Rhizoma Polygonati (processed) 90-150, Panax quinquefolium 6-10, Glehnia littoralis 45-90, Leonurus heterophyllus 90-160, Leonurus japonicus fruit 100-140, Radix Arnebiae and/or Radix Lithospermi 100-160, Chrysanthemum morifolium flower 50-90, Salvia miltiorrhiza 90-160, Scutellaria baicalensis 40-60, and Rhizoma Ligustici 50-80. The effective ingredients of the raw materials in the preparation are extracted by decoction, and activities thereof are remained, so as to remarkably improve the dissolution rate, promote absorption of the effective ingredients, and improve bioavailability. In addition, the preparation is a pure Chinese medicinal preparation, thereby resulting in good safety and no toxic or side effects after long-term administration. Moreover, the preparation method has the advantages of simple process and convenient operation.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, particularly relating to a kind of is brain-tonifying and intelligence-raising formulation of making of raw material and preparation method thereof with Chinese medicine.
Background technology
How dementia subtracts brain by marrow and disappears, and refreshing machine apraxia and causing is to be a kind of mind disease of main clinical manifestation with the slow-witted and stupid.The visible dull spirit of its lighter, speaking scarcely,taciturn, bradykinesia, forgetful disease such as grade; Heavy then show as keeping silence all day, or close Men Duyu, or mutter, words are put upside down, or movement without, cry suddenly and laugh at suddenly, or loss of appetite, a few days does not know hunger when one is hungry etc.Though it is many to be used for the treatment of dull-witted types of drugs at present clinically, specific aim is not strong, and the toxic and side effects of some medicine is big, so take the back belongs to the dull-witted this disease of deficiency of marrow-reservoir type to treatment DeGrain.
Summary of the invention
In order to address the above problem, the object of the present invention is to provide the dull-witted effect of a kind of treatment deficiency of marrow-reservoir type obvious, thereby with strong points, and the brain-tonifying and intelligence-raising formulation that has no side effect.
Another object of the present invention is to provide a kind of method that is used to prepare above-mentioned brain-tonifying and intelligence-raising formulation.
In order to achieve the above object, brain-tonifying and intelligence-raising formulation provided by the invention is that the following medicine material of weight ratio is made by consumption mainly:
Fructus Lycii 130-200 Radix Polygoni Multiflori Preparatas, 100-150 Rhizoma Polygonatis (system) 90-150
Radix Panacis Quinquefolii 6-10 Radix Glehniaes 45-90 Herba Leonuris 90-160
Fructus Leonuri 100-140 Radix Arnebiae (Radix Lithospermi)s 100-160 Flos Chrysanthemis 50-90
Radix Salviae Miltiorrhizae 90-160 Radix Scutellariaes 40-60 Rhizoma Ligusticis 50-80
The preparation method of described brain-tonifying and intelligence-raising formulation is to carry out according to the following step order:
(a) the said medicine raw material is carried out weighing according to proportioning, then with the Radix Panacis Quinquefolii full dose, Radix Glehniae, Radix Salviae Miltiorrhizae, each 1/3rd amount of Radix Scutellariae are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Radix Glehniae, Radix Salviae Miltiorrhizae, 8 kinds of medicine materials of Radix Scutellariae and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
Brain-tonifying and intelligence-raising formulation provided by the invention is that the method for employing decocting in water extraction is extracted the effective ingredient in the material medicine, and keep its activity, can make so not only that the dissolution of effective ingredient improves greatly in the medicine, and help the absorption of medicine, thereby can improve its bioavailability.In addition, medicine of the present invention is a pure Chinese medicinal preparation, thereby the patient can not produce toxic and side effects after taking for a long time, so safety is good.In addition, preparation method technology of the present invention is simple, easy to operate.
The specific embodiment
Fructus Lycii is sweet flat in the side, nourishing YIN and supplementing blood, replenishing vital essence to improve eyesight; The sweet tepor of Radix Polygoni Multiflori, invigorating the liver and kidney, benefiting essence-blood, two medicines are monarch drug altogether.Rhizoma Polygonati is sweet flat, and QI invigorating increases liquid, and the benefit of holding concurrently again is smart; Radix Panacis Quinquefolii is sweet cold, boosting qi and nourishing yin, clearing away heat and promoting production of body fluid; North Radix Salviae Miltiorrhizae hardship is slightly cold nourshing blood and promoting blood circulation, disease eliminating powder junction; Herba Leonuri, motherwort subsystem are given birth to root, have grass seed not, though but equal blood circulation promoting and blood stasis dispelling, but Fructus Leonuri has the merit of removing heat in the liver for improving eyesight, beneficial intensive culture blood concurrently; Radix Salviae Miltiorrhizae is sweet to be slightly cold, replenishing YIN and removing heat, and above health preserving with drugs blood benefit is smart, is ministerial drug altogether.Radix Arnebiae (Radix Lithospermi) is sweet cold, removing heat from blood and promoting blood circulation, sharp nine orifices, waterway; Hot sweet being slightly cold of Flos Chrysanthemi, dispelling wind and heat pathogens, liver heat removing and eyesight improving, to the hepatic and renal YIN deficiency, having a dizzy spell of excessive rising of liver-YANG has better curative effect.The Radix Scutellariae bitter cold, the kind part of the body cavity above the diaphragm housing the heart and lungs excess-fire of rushing down clearly is good at the most to dizziness and headache person due to the liver and gall excess-fire.This three medicine is thought adjuvant drug.The hot temperature of Rhizoma Ligustici is delivered cold expelling, expelling wind and dampness, it is strong to get its hot power of loosing in the side, and can on reach the top, mountain peak, draw the through sick institute of all medicines, and be messenger drug.
Below in conjunction with embodiment brain-tonifying and intelligence-raising formulation provided by the invention and preparation method thereof is elaborated.
Embodiment 1:
Brain-tonifying and intelligence-raising formulation in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Fructus Lycii 160 Radix Polygoni Multiflori Preparatas, 120 Rhizoma Polygonatis (system) 120
Radix Panacis Quinquefolii 8 Radix Glehniaes 80 Herba Leonuris 120
Fructus Leonuri 120 Radix Arnebiae (Radix Lithospermi)s 120 Flos Chrysanthemis 80
Radix Salviae Miltiorrhizae 160 Radix Scutellariaes 48 Rhizoma Ligusticis 64
Preparation method:
(a) the said medicine raw material is carried out weighing according to proportioning, then with the Radix Panacis Quinquefolii full dose, Radix Glehniae, Radix Salviae Miltiorrhizae, each 1/3rd amount of Radix Scutellariae are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Radix Glehniae, Radix Salviae Miltiorrhizae, 8 kinds of medicine materials of Radix Scutellariae and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
Embodiment 2:
Brain-tonifying and intelligence-raising formulation in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Fructus Lycii 130 Radix Polygoni Multiflori Preparatas, 100 Rhizoma Polygonatis (system) 90
Radix Panacis Quinquefolii 6 Radix Glehniaes 45 Herba Leonuris 90
Fructus Leonuri 100 Radix Arnebiae (Radix Lithospermi)s 100 Flos Chrysanthemis 50
Radix Salviae Miltiorrhizae 90 Radix Scutellariaes 40 Rhizoma Ligusticis 50
Preparation method is with embodiment 1.
Embodiment 3:
Brain-tonifying and intelligence-raising formulation in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Fructus Lycii 200 Radix Polygoni Multiflori Preparatas, 150 Rhizoma Polygonatis (system) 150
Radix Panacis Quinquefolii 10 Radix Glehniaes 90 Herba Leonuris 160
Fructus Leonuri 140 Radix Arnebiae (Radix Lithospermi)s 160 Flos Chrysanthemis 90
Radix Salviae Miltiorrhizae 160 Radix Scutellariaes 60 Rhizoma Ligusticis 80
Preparation method is with embodiment 1.
It is brown to sepia that brain-tonifying and intelligence-raising formulation provided by the invention is; Gas is light, and it is little sweet to distinguish the flavor of.In order to verify the therapeutic effect of this brain-tonifying and intelligence-raising formulation, the patient that the inventor utilizes the capsule that belongs to oral administration solid system in the above-mentioned brain-tonifying and intelligence-raising formulation that 198 examples are suffered from deficiency of marrow-reservoir type dementia has carried out system's clinical observation, 3 of each medications, every day 2 times, 60 days is 1 course of treatment.After 1 course of therapy, cure (cardinal symptom obviously alleviates, and mind is recovered as ordinary person) 23 examples altogether, account for 11.6%; Effectively (cardinal symptom obviously alleviates, but mind still has unusual performance) 155 examples account for 78.3%; Invalid (cardinal symptom does not have significant change) 20 examples account for 10.1%; Total effective rate is 89.9%.After 2 course of therapy, cure 52 examples altogether, account for 26.3%; Effective 138 examples account for 69.7%; Invalid 8 examples account for 4.0%; Total effective rate is 96.0%.
Simultaneously, the inventor analyzes therapeutic effect and the relation between the course of treatment, and analysis result sees Table 1.
Table 1: brain-tonifying and intelligence-raising formulation therapeutic effect provided by the invention and the course of treatment relation table
With the data x in the above-mentioned table 1
2Method of inspection calculates, and the result is P＜0.005, can prove that thus taking brain-tonifying and intelligence-raising formulation provided by the invention treats deficiency of marrow-reservoir type dementia, and along with going deep into of treatment, cure rate, effective percentage all obviously improve.
Claims (1)
1. brain-tonifying and intelligence-raising formulation that is used for the treatment of deficiency of marrow-reservoir type dementia is characterized in that: the described brain-tonifying and intelligence-raising formulation that is used for the treatment of deficiency of marrow-reservoir type dementia is that the following medicine material of weight ratio is made by consumption:
Fructus Lycii 130-200 Radix Polygoni Multiflori Preparata 100-150 Rhizoma Polygonati (processed) 90-150
Radix Panacis Quinquefolii 6-10 Radix Glehniae 45-90 Herba Leonuri 90-160
Fructus Leonuri 100-140 Radix Arnebiae (Radix Lithospermi) 100-160 Flos Chrysanthemi 50-90
Radix Salviae Miltiorrhizae 90-160 Radix Scutellariae 40-60 Rhizoma Ligustici 50-80,
Described formulation preparation method is to carry out according to the following step order:
(a) the said medicine raw material is carried out weighing according to proportioning, then with the Radix Panacis Quinquefolii full dose, Radix Glehniae, Radix Salviae Miltiorrhizae, each 1/3rd amount of Radix Scutellariae are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Radix Glehniae, Radix Salviae Miltiorrhizae, 8 kinds of medicine materials of Radix Scutellariae and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101519180A CN101375996B (en) | 2008-09-27 | 2008-09-27 | Brain-tonifying and intelligence-raising formulation and preparation method thereof |
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| CN2008101519180A CN101375996B (en) | 2008-09-27 | 2008-09-27 | Brain-tonifying and intelligence-raising formulation and preparation method thereof |
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| CN101375996A CN101375996A (en) | 2009-03-04 |
| CN101375996B true CN101375996B (en) | 2010-12-08 |
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| CN106177046A (en) * | 2016-08-29 | 2016-12-07 | 杨添福 | A kind of nervus cognition disorder medicine based on the exploitation of Pu Lining potassium and preparation method thereof |
| CN106943525A (en) * | 2017-04-18 | 2017-07-14 | 张�诚 | A kind of pure Chinese medicinal preparation for treating brain dementia |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1451382A (en) * | 2003-04-21 | 2003-10-29 | 随州三江源药业有限公司 | Medicine for treating senile dementia and preparing process thereof |
| CN1739776A (en) * | 2005-09-10 | 2006-03-01 | 李亚萍 | Chinese herbal medicine decoction for treating senile dementia caused by marrow sea deficiency |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1451382A (en) * | 2003-04-21 | 2003-10-29 | 随州三江源药业有限公司 | Medicine for treating senile dementia and preparing process thereof |
| CN1739776A (en) * | 2005-09-10 | 2006-03-01 | 李亚萍 | Chinese herbal medicine decoction for treating senile dementia caused by marrow sea deficiency |
Non-Patent Citations (3)
| Title |
|---|
| 周磊等.老年性痴呆的中医药研究.《中医药临床杂志》.2007,第19卷(第2期),第183-185页. * |
| 尚炽昌等.地黄饮子加味治疗髓海不足型老年呆病的临床报道.《中国医药学报》.1996,第11卷(第5期),第36-38页. * |
| 袁力.试述老年痴呆的病机与治法.《实用中医药杂志》.2005,第21卷(第2期),第109页. * |
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Effective date of registration: 20170606 Address after: 300210 Tianjin city Hexi District Liberation Road No. 447 Patentee after: Tianjin Caokaiyong Hospital of traditional Chinese Medicine Address before: Yingkou Heping District 300040 Tianjin City Road 36 No. E119 Patentee before: Cao Kaiyong |
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