CN103472218B - Colloidal gold chart reader and corresponding control method - Google Patents
Colloidal gold chart reader and corresponding control method Download PDFInfo
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- CN103472218B CN103472218B CN201310449250.9A CN201310449250A CN103472218B CN 103472218 B CN103472218 B CN 103472218B CN 201310449250 A CN201310449250 A CN 201310449250A CN 103472218 B CN103472218 B CN 103472218B
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- 241001025261 Neoraja caerulea Species 0.000 claims description 10
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- 238000012545 processing Methods 0.000 description 10
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- 108090000623 proteins and genes Proteins 0.000 description 7
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
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- FDWREHZXQUYJFJ-UHFFFAOYSA-M gold monochloride Chemical compound [Cl-].[Au+] FDWREHZXQUYJFJ-UHFFFAOYSA-M 0.000 description 2
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- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
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- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical group [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- Spectrometry And Color Measurement (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Disclosed is a colloidal gold chart reader. The colloidal gold chart reader comprises a main control unit, an on-screen display unit electrically connected with the main control unit, an optical unit and a lighting unit. The lighting unit comprises a color control unit which outputs lighting light in corresponding colors according to different set lighting colors. By the adoption of the colloidal gold chart reader, a colloidal gold testing method can be adapted to different colors of samples to be detected and is wider in application range, the colloidal gold chart reader and the testing process are more standardized and processized, and detection results are more accurate and more reliable.
Description
Technical field
The present invention relates to a kind of collaurum examination chart scanner and corresponding control method.
Background technology
Device for quick testing for test chemistry and biological substance is extensively quoted, and often replaces the test in some traditional laboratories.These proving installations comprise polytype test, are used to carry out such as human diagnostic, herding test and food product environment test etc.
Be used for testting the digital fetch equipment of proving installation to be also widely used, they are mainly imitated and to be designed by the mode of the manual diagnosis such as bore hole, microscope or magnifier.This equipment uses and also applies image processing technique to carry out to improve the mankind and test or diagnose.This raising is by applying the sensitive of other but the technology that can realize.
Colloidal gold method uses the widest a kind of method of testing at present.Collaurum be by gold chloride (HAuCl4) at reductive agent as under the effect such as white phosphorus, ascorbic acid, sodium citrate, tannic acid, can be grouped to a certain size gold grain, and become a kind of stable colloidal state due to electrostatic interaction, form electronegative hydrophobic sol solution, become stable colloidal state due to electrostatic interaction, therefore claim collaurum.Collaurum is electronegative under mild alkaline conditions, can be formed firmly be combined, because this combination is electrostatical binding, so do not affect the biological nature of protein with the positive charge group of protein molecule.Collaurum except with protein bound except, can also be combined with other biomacromolecules many.According to some physical behaviors of collaurum, as high electron density, grain size, shape and color reaction, add immunity and the biological characteristics of bond, thus make collaurum be widely used in the fields such as immunology, histology, pathology and cell biology.Colloid gold label is in fact that the macromolecules such as protein are adsorbed to the bag on colloid gold particle surface by process.Adsorption mechanism may be colloid gold particle surface negative charge, forms strong bonded with the positive charge group of protein because of Electrostatic Absorption.The colloid gold particle of various different-grain diameter, namely different colours can be prepared easily from gold chloride by reducing process.This spherical particle has very strong adsorption function to protein, can with the Non-covalent binding such as staphylococcal protein A, immunoglobulin (Ig), toxin, glycoprotein, enzyme, microbiotic, hormone, bovine serum albumin polypeptide conjugate, thus in fundamental research and clinical trial, become very useful instrument.
Immuno-gold labeling technology (Immunogold labelling technique) mainly make use of the characteristic that gold grain has high electron density, at gold mark protein combination place, visible pitchy particle under the microscope, when these labels are assembled in a large number at corresponding part place, naked eyes red color visible or pink spot, thus in qualitative or semiquantitative tachysynthesis detection method, this reaction also can be exaggerated by the deposition of Argent grain, is referred to as immunogold silver staining.
Fig. 1 is colloidal gold test paper card schematic diagram.In general, colloidal gold test paper card 1 mainly comprises sample well 2 and viewport 3, and viewport 3 is provided with detection line 5(and T line) and nature controlling line 4(and C line).At present, the measuring method of colloidal gold test paper card is the judgement that detects by an unaided eye, and namely after reagent adds and waits for the stipulated time after colloidal gold test paper card 1, detects by an unaided eye the color distinction of nature controlling line 4 and detection line 5 to judge testing result by operator.This method is a kind of way of manual Macroscopic analysis, also exist resolution low, can only observational measurement, measurement result depend on operator individual subjective experience, measure have that very big subjectivity, False Rate are higher, measurement result can only hand-kept, the not easily drawback such as saving result.Therefore, the colloidal gold chart reader for colloidal gold test paper card has just been come out.
Fig. 2 is the schematic diagram of colloidal gold chart reader on present market (also known as gold mark readout instrument).Colloidal gold chart reader 10 comprises main control unit 11, for the normal work of control instrument; Screen display unit 12 is for showing test process and test result; Graphics processing unit 13 is for carrying out analyzing and processing to the result captured by optical unit 16; Optical unit 16 is for carrying out optical detection to the colloidal gold test paper card putting into test section 14, graphics processing unit 13 obtains the gray-scale value of colloidal gold test paper card nature controlling line and detection line, and main control unit 11 determines testing result by the ratio calculating detection line gray-scale value and nature controlling line gray-scale value.
The problem that before although colloidal gold chart reader can solve, manual Macroscopic analysis way also exists, but also there is more rooms for improvement, wherein the optical brightness value of detection line and nature controlling line is owing to being subject to the body color stain of checking matter, as blood takes on a red color, urine, in yellow, greatly have impact on the accuracy of sentence read result.How to reduce background interference, improve sentence read result accuracy, just become very crucial technology.
Summary of the invention
The object of this invention is to provide a kind of colloidal gold chart reader, the detection of different tested samples can be adapted to, especially adapt to the detection of the tested sample of different colours.
To achieve these goals, the invention provides a kind of colloidal gold chart reader, described chart scanner comprises, main control unit and be connected electrically ground screen display unit, optical unit and lighting unit, described lighting unit comprises color control unit, and described color control unit, according to the different illuminating color of setting, exports the illumination light of respective color.
Further, described lighting unit also comprises red-light LED, green light LED, blue-ray LED, and described color control unit controls its luminescence.
Further, described lighting unit also comprises white light LEDs.
Further, described lighting unit also comprises even tabula rasa.
Further, described red-light LED, green light LED, blue-ray LED is a plurality of.
Further, described lighting unit is LCD module.
Further, described lighting unit is OLED module.
The present invention also provides a kind of control method for colloidal gold chart reader, and described colloidal gold chart reader comprises lighting unit, and described method comprises, and the color setting described lighting unit is A, and described lighting unit exports color A; The color of setting lighting unit is B, and described lighting unit exports color B; Described color A is different from described color B.
Further, described method also comprises, after having reacted, the photo of shooting colloidal gold test paper card, background process is gone to taken photo, calculate optical brightness value Bt and the Bc of the colloidal gold test paper card detection line and nature controlling line through going background process, and determine the concentration of checking matter in sample according to the value of Bt/Bc.
After adopting colloidal gold chart reader above, colloidal gold test method can adapt to the tested sample of different colours, and range of application is wider, and instrument and test process be standardization more also, procedure, and testing result is also more accurate, more reliably.
Accompanying drawing explanation
Fig. 1 is colloidal gold test paper card schematic diagram;
Fig. 2 is the schematic diagram of colloidal gold chart reader on present market;
Fig. 3 is colloidal gold chart reader schematic diagram of the present invention;
Fig. 4 is lighting unit embodiment one schematic diagram of colloidal gold chart reader of the present invention;
Fig. 5 is the workflow diagram of colloidal gold chart reader of the present invention.
Embodiment
Fig. 3 is the system framework schematic diagram of colloidal gold chart reader of the present invention.Colloidal gold chart reader 20 comprises main control unit 21, for the normal work of control instrument; Screen display unit 22 is for showing test process and test result; Graphics processing unit 23 is for carrying out analyzing and processing to the result captured by optical unit 26; Optical unit 26 is for carrying out optical detection to the colloidal gold test paper card 25 putting into test section 24, graphics processing unit 23 obtains the optical brightness value of colloidal gold test paper card detection line and nature controlling line, wherein needs to remove through background the background that module 30 removes detection line and nature controlling line; Main control unit 21 determines testing result by the ratio calculating detection line optical brightness value and nature controlling line optical brightness value; Test section temperature humidity control module 27 is for controlling the humidity and temperature of test section 24; Network communication unit 28 is for uploading or Download Info.Storage unit 29 is for storing corresponding data, and as the photo, test process, test result etc. of shooting, all data uploaded through network communication unit 28 can first be stored in here.Lighting unit 31, for throwing light on to test section 24, when optical unit 26 carries out optical detection, starts lighting unit 31, makes the clear picture of shooting.
In the prior art, lighting unit is normally white, or the light of other solid color, mainly arrange to detect a certain sample, the photo of shooting is after background is removed, calculate optical brightness value Bt and the Bc of detection line and nature controlling line, and determine the concentration of checking matter in sample according to the value of Bt/Bc.Determine that in sample, the concentration of checking matter is prior art according to the value of Bt/Bc.But the principle of colloidal gold chart reader is general, must can be different test sample, as urine, blood etc., the test sample effect of light when background is removed to different of solid color is different.In order to adapt to different test samples, the lighting unit 31 of colloidal gold chart reader of the present invention can control the color of illumination light, arranges different illumination light color according to different test samples.
Fig. 4 is lighting unit embodiment one schematic diagram of colloidal gold chart reader of the present invention.Lighting unit 31 comprises color control unit 311, red-light LED 314, green light LED 313, blue-ray LED 312, and even tabula rasa 315.Color control unit 311 according to arrange illumination light color, calculate red-light LED 314, green light LED 313, the color matching ratio of blue-ray LED 312, and drive red-light LED 314 respectively according to ratio, green light LED 313 and blue-ray LED 312 luminous in proportion.Even tabula rasa 315 pairs of red-light LEDs 314, the light that green light LED 313 and blue-ray LED 312 send carries out Homogenization Treatments, then impinge upon on colloidal gold test paper card 25 as illumination light, optical unit 26 takes corresponding photo, the photo of shooting is after background is removed, calculate optical brightness value Bt and the Bc of detection line and nature controlling line, and determine the concentration of checking matter in sample according to the value of Bt/Bc.
Fig. 5 is the workflow diagram of colloidal gold chart reader of the present invention.
Step 50, the color of setting lighting unit; Color i.e. its glow color of lighting unit, color value can set according to the recommended value of producer, and if R=0, G=255, B=0 are green glow, R=255, G=255, B=255 are white light.
Step 51, the respectively output of control R/G/B LED; Color control unit 311 according to arrange illumination light color, calculate red-light LED 314, green light LED 313, the color matching ratio of blue-ray LED 312, and drive red-light LED 314 respectively according to ratio, green light LED 313 and blue-ray LED 312 luminous in proportion.
Step 52, according to the response time until reacted; Response time is the time span when extremely having reacted after test sample instillation colloidal gold test paper card.The producer of colloidal gold test paper card all can provide the response time of colloidal gold test paper card.
Step 53, optical unit 26 takes the photo of colloidal gold test paper card.
Step 54, goes background process to taken photo.
Step 55, calculates the optical brightness value of the colloidal gold test paper card detection line and nature controlling line through going background process; Graphics processing unit 23, for carrying out analyzing and processing to the result captured by optical unit 26, comprises background process; Graphics processing unit 23 obtains optical brightness value Bt, the Bc of colloidal gold test paper card detection line and nature controlling line, and main control unit 21 calculates the value of Bt/Bc, and calculates corresponding checking matter concentration according to stored testing result judgment curves.
Step 56, exports and store test results; Screen display unit 22 shows test results.
Step 57, uploads onto the server test result.
The lighting unit of the colloidal gold chart reader of the present invention shown in Fig. 4, R wherein G B LED luminescence unit can be one group, also can be set to plural groups as required.In addition, luminescence unit can also arrange white light LEDs separately, when arranging white-light illuminating, provides illumination with white light LEDs.
In order to control cost and modularization, lighting unit can also be LCD liquid crystal screen module, can simplify the design of product like this.
Except LCD liquid crystal screen module, lighting unit also can be other color display module, as OLED (Organic Light Emitting Diode), etc.
Last it is noted that the above embodiment only unrestricted technical scheme of the present invention in order to explanation; those of ordinary skill in the art can modify to the present invention or equivalent replacement; and not departing from any modification or partial replacement of the spirit and scope of the present invention, it all should be encompassed in claims of the present invention.
Claims (9)
1. a colloidal gold chart reader, described chart scanner comprises, main control unit and the screen display unit be connected electrically, optical unit and lighting unit, it is characterized in that, described lighting unit comprises illuminating color control module, and described illuminating color control module, according to the different illuminating color of different standby sample product setting, controls the illumination light that described lighting unit exports respective color.
2. colloidal gold chart reader as claimed in claim 1, it is characterized in that, described lighting unit also comprises red-light LED, green light LED, blue-ray LED, described illuminating color control module is according to the different illuminating color of setting, control it in proportion luminous, export different illuminating colors.
3. colloidal gold chart reader as claimed in claim 2, it is characterized in that, described lighting unit also comprises white light LEDs.
4. as the colloidal gold chart reader in claim 1 or 2 as described in any one, it is characterized in that, described lighting unit also comprises even tabula rasa.
5. as the colloidal gold chart reader in Claims 2 or 3 as described in any one, it is characterized in that, described red-light LED, green light LED, blue-ray LED is a plurality of.
6. colloidal gold chart reader as claimed in claim 1, it is characterized in that, described lighting unit is LCD module.
7. colloidal gold chart reader as claimed in claim 1, it is characterized in that, described lighting unit is OLED module.
8. the control method for colloidal gold chart reader as claimed in any of claims 1 to 7 in one of claims; described colloidal gold chart reader comprises lighting unit, it is characterized in that, described method comprises; the color setting described lighting unit is A, and described lighting unit exports color A; The color of setting lighting unit is B, and described lighting unit exports color B; Described color A is different from described color B.
9. control method as claimed in claim 8, it is characterized in that, described method also comprises, after having reacted, the photo of shooting colloidal gold test paper card, background process is gone to taken photo, calculates optical brightness value Bt and the Bc of the colloidal gold test paper card detection line and nature controlling line through going background process, and determine the concentration of checking matter in sample according to the value of Bt/Bc.
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| CN104111330B (en) * | 2014-07-18 | 2016-03-09 | 中国科学院上海光学精密机械研究所 | Up-conversion luminescence immunochromatographiassays assays instrument and detection method |
| CN104964973A (en) * | 2015-07-08 | 2015-10-07 | 邓双胜 | Test paper reading and analyzing method and system based on mobile terminal camera |
| CN109856133B (en) * | 2019-01-29 | 2021-06-22 | 深圳市象形字科技股份有限公司 | Test paper detection method utilizing multiple illumination intensities and multiple color illumination |
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| US7910381B2 (en) * | 2005-10-13 | 2011-03-22 | BioAssay Works | Immuno gold lateral flow assay |
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