CN103417811A

CN103417811A - Chinese herbal preparation for treating recurrent oral ulceration

Info

Publication number: CN103417811A
Application number: CN2013103450509A
Authority: CN
Inventors: 王娟
Original assignee: Individual
Current assignee: Sun Xiujuan
Priority date: 2013-08-04
Filing date: 2013-08-04
Publication date: 2013-12-04
Anticipated expiration: 2033-08-04
Also published as: CN103417811B

Abstract

The invention discloses a Chinese herbal preparation for treating recurrent oral ulceration. According to the traditional Chinese medicine, recurrent oral ulceration is caused by spleen deficiency, lack of stomach Yin, flaming of asthenia-fire and allaesthetic wind-fire pathogenic heat invading mouth. Therefore, Rubus alceaefolius Poir, Herb of Thymeleaf Speed welt, Caesalpinia minax Hance, souliea vaginata, cape jasmine fruit, Gypsum, spiral shell, rhizoma panasis japonici, lucid asparagus, Atractylis ovata and liquorice are chosen and decocted in water to obtain a decoction, and clinical tests show that the total effective rate reaches 97.3% and the curative effect is remarkably superior to the control group.

Description

A kind of Chinese medicine preparation for the treatment of recurrent oral ulceration

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of recurrent oral ulceration.

Background technology

It is the commonly encountered diseases of oral mucosa that recurrent oral ulceration has another name called " recurrent aphthous ulcer " or " recurrent aphtha " (be called for short ROU), is to take the chronic inflammatory disease that painful ulcer that oral mucosa shows effect repeatedly is characteristics; It is modal ulcer infringement in the disease of cari oris mucosa, it shows as oral mucosa and that isolate, circular or oval skin ulcer repeatedly occur, obvious causalgia is arranged, fester, periodically, migration rule outbreak repeatedly, general women is slightly more than the male, its cause of disease is not yet clear and definite, though the western medical treatment method is many, but curative effect is not ideal enough, and relapse rate is high, sometimes directly affects people's daily life.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of recurrent oral ulceration.Motherland's medical science thinks that recurrent oral ulceration is insufficiency of the spleen deficiency of stomach-Yin, and hyperactivity of deficient fire, feel again on the wind-fire pathogenic heat and attack in mouth and fall ill.

The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment recurrent oral ulceration is made by the Chinese medicine of following weight portion: Radix seu Folium Rubi alceaefolii 20-30 part, Herba Veronicae Serpyllifoliae 5-10 part, Semen Caesalpiniae Minacis 7-13 part, Rhizoma soulieae vaginatae 10-15 part, Fructus Gardeniae 9-12 part, Gypsum Fibrosum 15-20 part, Carapax Bellamyae quadratae 13-18 part, Rhizoma Tupistrae ensifoliae 6-11 part, Radix Asparagi 7-14 part, Rhizoma Atractylodis Macrocephalae 15-18 part, Radix Glycyrrhizae 4-6 part.

Preferably, 25 parts of Radix seu Folium Rubi alceaefoliis, 7.5 parts of Herba Veronicae Serpyllifoliaes, 10 parts of Semen Caesalpiniae Minaciss, 13 parts of Rhizoma soulieae vaginataes, 9 parts of Fructus Gardeniaes, 18 parts, Gypsum Fibrosum, 15 parts of Carapax Bellamyae quadrataes, 8 parts of Rhizoma Tupistrae ensifoliaes, 11 parts of Radix Asparagi, 16 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts, Radix Glycyrrhizae.

Preparation method: above-mentioned Chinese medicine decocting is made to decoction.

In side: Radix seu Folium Rubi alceaefolii, Herba Veronicae Serpyllifoliae clearing away heat and cooling blood, removing toxic substances, promoting blood circulation and hemostasis; The Semen Caesalpiniae Minacis clearing away heat and eliminating dampness, eliminating stasis to stop pain; Rhizoma soulieae vaginatae, Fructus Gardeniae, Gypsum Fibrosum pathogenic fire purging dampness, the relieving restlessness that clears away heart-fire, anti-inflammation, stomach invigorating, clearing away heat and promoting diuresis; The Carapax Bellamyae quadratae eliminating stagnation, the pain relieving sore; Rhizoma Tupistrae ensifoliae, Radix Asparagi nourishing yin and purging fire, invigorate blood circulation, nourishing YIN to relieve dryness; The Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae air making-up and spleen enlivening, the dampness diuretic, the QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, alleviate pain relieving, the mediation property of medicine.

Clinical data

1, physical data: selected case derives from the court's traditional Chinese medical science Stomatology Clinic Patients with RAU totally 150 examples.Be divided at random treatment group and matched group: treatment group 75 examples, male 30 examples wherein, female's 45 examples, minor aphtha 58 examples, stomatitis type aphtha 14 examples, periglandular aphthae 3 examples; Minimum 15 years old of age, maximum 60 years old; The course of disease is the shortest 2 years, the longest 14 years.Matched group 75 examples, male 32 examples wherein, female's 43 examples, minor aphtha 56 examples, stomatitis type aphtha 15 examples, periglandular aphthae 4 examples; Minimum 16 years old of age, maximum 65 years old; The course of disease is the shortest 2.5 years, the longest 15 years.In therapeutic process, the other medicines of all stopping using.The equal not statistically significants of difference (P<0.05) such as two groups of sexes, age, the state of an illness, the course of disease, have comparability.

2, diagnostic criteria: (1) meets the diagnostic criteria in national state-compiled textbook " oral medicine ".The course of disease>6 month, outbreak, show effect 1～2 time per month repeatedly.(2) get rid of other diseases of oral mucosa, and the patient is without serious whole body illness.(3) patient does not take the medicine of any treatment oral ulcer in 1 month, and this morbidity is to medical front without any treatment.(4) medical in morbidity 3 days.

3, Therapeutic Method: treatment group is taken Chinese medicine composition of the present invention, take Radix seu Folium Rubi alceaefolii 25g, Herba Veronicae Serpyllifoliae 7.5g, Semen Caesalpiniae Minacis 10g, Rhizoma soulieae vaginatae 13g, Fructus Gardeniae 9g, Gypsum Fibrosum 18g, Carapax Bellamyae quadratae 15g, Rhizoma Tupistrae ensifoliae 8g, Radix Asparagi 11g, Rhizoma Atractylodis Macrocephalae 16g, Radix Glycyrrhizae 5g, decocting becomes decoction, every day, potion, divided morning, evening to take for 2 times.Matched group gives vitamin B ₂10mg, vitamin C 100mg, oral, two groups equal 7 days be a course for the treatment of, serve on 2 courses for the treatment of.

4, criterion of therapeutical effect: with reference to Chinese stomatology meeting " recurrent oral ulceration therapeutic evaluation tentative standard ".Oral ulcer stopped recurrence more than 1 year, was recovery from illness; Total intermittent time extends, and total ulcer number reduces, and is produce effects; Total intermittent time extends, but total ulcer number do not reduce, or total intermittent time without change, but total ulcer number reduces, for effectively; Total intermittent time and total ulcer number are all without changing, for invalid.

5, therapeutic outcome: after two groups of treatments two courses for the treatment of curative effect relatively, the routine patient for the treatment of group 75,57 examples of wherein fully recovering (76.0), produce effects 11 examples (14.7), invalid 2 examples of effective 5 examples (6.7) (2.7), total effective rate is 97.3%; The routine patient of matched group 75,18 examples of wherein fully recovering (24.0), produce effects 20 examples (26.7), invalid 14 examples of effective 23 examples (30.7) (18.7) total effective rate is 81.3%; Two groups relatively, and treatment group recovery rate, total effective rate, obviously be better than matched group, and P<0.05 has comparability.

The specific embodiment

Embodiment mono-: take Radix seu Folium Rubi alceaefolii 25g, Herba Veronicae Serpyllifoliae 7.5g, Semen Caesalpiniae Minacis 10g, Rhizoma soulieae vaginatae 13g, Fructus Gardeniae 9g, Gypsum Fibrosum 18g, Carapax Bellamyae quadratae 15g, Rhizoma Tupistrae ensifoliae 8g, Radix Asparagi 11g, Rhizoma Atractylodis Macrocephalae 16g, Radix Glycyrrhizae 5g, above-mentioned Chinese medicine decocting is made to decoction.

Embodiment bis-: take Radix seu Folium Rubi alceaefolii 30g, Herba Veronicae Serpyllifoliae 10g, Semen Caesalpiniae Minacis 13g, Rhizoma soulieae vaginatae 10g, Fructus Gardeniae 12g, Gypsum Fibrosum 20g, Carapax Bellamyae quadratae 18g, Rhizoma Tupistrae ensifoliae 6g, Radix Asparagi 14g, Rhizoma Atractylodis Macrocephalae 18g, Radix Glycyrrhizae 6g, above-mentioned Chinese medicine decocting is made to decoction.

Embodiment tri-: take Radix seu Folium Rubi alceaefolii 20g, Herba Veronicae Serpyllifoliae 5g, Semen Caesalpiniae Minacis 7g, Rhizoma soulieae vaginatae 15g, Fructus Gardeniae 9g, Gypsum Fibrosum 15g, Carapax Bellamyae quadratae 13g, Rhizoma Tupistrae ensifoliae 11g, Radix Asparagi 7g, Rhizoma Atractylodis Macrocephalae 15g, Radix Glycyrrhizae 4g, above-mentioned Chinese medicine decocting is made to decoction.

Claims

1. a Chinese medicine preparation for the treatment of recurrent oral ulceration, is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: Radix seu Folium Rubi alceaefolii 20-30 part, Herba Veronicae Serpyllifoliae 5-10 part, Semen Caesalpiniae Minacis 7-13 part, Rhizoma soulieae vaginatae 10-15 part, Fructus Gardeniae 9-12 part, Gypsum Fibrosum 15-20 part, Carapax Bellamyae quadratae 13-18 part, Rhizoma Tupistrae ensifoliae 6-11 part, Radix Asparagi 7-14 part, Rhizoma Atractylodis Macrocephalae 15-18 part, Radix Glycyrrhizae 4-6 part.

2. a kind of Chinese medicine preparation for the treatment of recurrent oral ulceration according to claim 1, is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: 25 parts of Radix seu Folium Rubi alceaefoliis, 7.5 parts of Herba Veronicae Serpyllifoliaes, 10 parts of Semen Caesalpiniae Minaciss, 13 parts of Rhizoma soulieae vaginataes, 9 parts of Fructus Gardeniaes, 18 parts, Gypsum Fibrosum, 15 parts of Carapax Bellamyae quadrataes, 8 parts of Rhizoma Tupistrae ensifoliaes, 11 parts of Radix Asparagi, 16 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts, Radix Glycyrrhizae.