CN103054044B - Sleep-improving health food composition - Google Patents
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Abstract
The invention relates to a sleep-improving health food composition which comprises the following raw materials by weight: 8 to 40 parts of gamma-aminobutyric acid powder, 0.8 to 8 parts of a Chinese magnoliavine extract, 5 to 20 parts of a calcium-containing compound, 5 to 20 parts of a magnesium-containing compound and 0.01 to 1 part of vitamin B6. The invention further provides a sleep-improving preparation and a preparation method thereof. The sleep-improving health food composition and the sleep-improving preparation use gamma-aminobutyric acid powder, the Chinese magnoliavine extract, the calcium-containing compound, the magnesium-containing compound and the vitamin B6 as main components, do not contain the component of hypnotics, can effectively soothe emotion of a stressed population and people with bad sleep and improve sleep quality.
Description
Technical field
The present invention relates to food or field of health care products, particularly a kind of health-care food composition that improves sleep.
Background technology
Sleep in the whole world that international mental hygiene tissue is sponsored and health plan has initiated in calendar year 2001 that a global activity-by annual March 21, the first day in spring was decided to be " World Sleep Day ".People has time of 1/3rd to spend in sleep in life, within five days, sits up and will affect people's existence, and visible sleep is one of important physiological requirements of people.Sleep is the necessary process of life, is the important step of body recovery, integration and consolidating memory, is healthy indispensable part.
Due to modern society's dog-eat-dog, people's thought pressure is large, causes the long-term insomnia of many people or sleep quality not high.Show according to interrelated data, the whole nation at present existing more than 50% people has difficulty in going to sleep and the phenomenon of having a sleepless night, and due to long-term insomnia, many people have suffered from many relevant diseases.Sleep-disorder has become the mankind's a large killer.Now become one and be difficult to the disease of curing, brought huge hidden danger to people's life, work, study.Up to the present, Cure for insomnia aspect there is no effective ways and specific medicament, many people take hypnotic and carry out relieving insomnia, if things go on like this make people produce drug dependence, have also caused thus the generation of other diseases, also many toxic and side effects have been caused, serious harm people's health, people's thought pressure is increased, insomnia has been produced to powerful fear, Psychological phobia, causes vicious circle.
At present conventional hypnotic has Benzodiazepines, barbiturates and other non-barbiturateses clinically, the effect of its Cure for insomnia is obvious, but affect larger on its liver, kidney, user easily produces the dependence to medicine, conventionally continue to increase pharmaceutical dosage and could keep effect, but also can produce very large toxic and side effect, be not therefore the medicine that is applicable to long-term taking.The people that some is taken medicine for a long time in a large number, if reduce suddenly dosage or cut out, also can be with n or V, the coarse tremor of hand, tongue and eyelid, causes conduct disorder, occurs illusion, even epileptic attack.
At present, existing a lot of materials that adopt integration of drinking and medicinal herbs, the health food that can improve sleep composite according to Chinese medical discrimination principle.
CN102600299A discloses a kind of compound improvement sleep electuary and preparation method thereof, processes taking the 30-35% fruit of Chinese magnoliavine, 20-25% wilsonii, 5-10% polygala root, 10-15% spina date seed, 20-25% matrimony vine and 5-10% red date as primary raw material.
CN102133331A discloses a kind of the have capsule and the preparation technology thereof that improve sleep function, is by spina date seed 600g, the capsule that fruit of Chinese magnoliavine 500g, ginseng 200g, the tuber of dwarf lilyturf, 150g, polygala root 150g, Poria cocos 30g, starch 20g made.
Therefore develop the composite health-care food composition forming of a kind of material by integration of drinking and medicinal herbs, there is prospect widely.
Summary of the invention
The object of this invention is to provide a kind of health-care food composition that improves sleep, can effectively releive high pressure crowd and dyssomnia person's mood of described health-care food composition, improves sleep.
Health-care food composition provided by the invention comprises the raw material of following weight portion: GABA powder 8-40 part, Schisandra chinens P.E 0.8-8 part, calcium containing compound 5-20 part, magnesium-containing compound 5-20 part, Cobastab
60.01-1 part.
Preferably, described health-care food composition comprises the raw material of following weight portion: GABA powder 12-25 part, Schisandra chinens P.E 1-5 part, calcium containing compound 10-15 part, magnesium-containing compound 10-15 part, Cobastab
60.1-0.5 part.
Most preferably, described health-care food composition comprises the raw material of following weight portion: 25 parts, GABA powder, 5 parts of Schisandra chinens P.Es, 12 parts of calcium containing compounds, 12 parts of magnesium-containing compounds, Cobastab
60.5 part.
Wherein, described GABA powder is extractive from fermentative, and commercially available acquisition is preferably 20 type GABA powder, and the mass content of its GABA is 20%.
Wherein, described Schisandra chinens P.E is water extract, and its withdrawal ratio is 5:1, commercially available acquisition.
Described calcium containing compound is salt, the oxide of calcic etc. of calcic; Described magnesium-containing compound is salt, the oxide that contains magnesium etc. that contains magnesium.
Preferably, described calcium containing compound is selected from one or more in calcium carbonate, calcium gluconae, calcium citrate, calcium lactate, calcium glycine.
Preferably, described magnesium-containing compound is selected from one or more in magnesium sulfate, magnesium gluconate, magnesia, magnesium chloride, magnesium lactate, magnesium glycinate.
GABA has another name called 4-Aminobutanoicacid (4-Aminobutanoic acid, 4-AB, be called for short GABA) and GABA, it is a kind of naturally occurring nonprotein amino acid, be the important inhibitory neurotransmitter of mammalian central nervous system, approximately 50% nervous centralis cynapse position is taking GABA as mediator.In human brain cortex, hippocampus, thalamus, basal ganglion and cerebellum, play an important role, and the several functions of body is had to regulating action.Have important physiological function, the physiologically active of having reported has the blood pressure of adjusting, impels ataraxy, promotes brain blood flow, promotes brain vigor, trophic nerve cell, increase growth hormone secretion, strong liver profit kidney, prevention of obesity, promotion alcohol metabolism (sobering up), improve the multiple efficacies such as climacteric metancholia.It can promote the reactivity of brain, brain tonic and intelligence development, and anti-epileptic, promotes sleep, beauty treatment moisturizing, delays brain aging function, can supplement human body inhibitory neurotransmitter, has good blood pressure reduction effect; Promote kidney function to improve and protective effect; Suppress fatty liver and obesity, activation liver function.GABA belongs to strong neural inhibitory aminoacid, has calmness, hypnosis, anticonvulsion, hypotensive physiological action.Can suppress the activity of animal, reduce the consumption of energy.Aminobutyric acid acts on the GABA acceptor in zooblast, GABA acceptor is a chloride channel, the inhibition of GABA or excitability are to depend on the inside and outside chlorine ion concentration of cell membrane, after GABA acceptor is activated, cause chloride channel open, can increase cell membrane to chlorion permeability, chlorion is flowed in nerve cell, cause cell membrane hyperpolarization, suppress nerve cell unit exciting, thereby reduce the amount of exercise of animal.It is the unintentional motion by reducing animal, reduces energy consumption, thereby reaches somatotrophic object.Gabanergic promotes the secretion of animal gastric juice and growth hormone, thereby improves the speed of growth and feed intake; The maincenter of searching for food of the excited animal of energy, thus feed intake increased.In recent years finding that GABA has trophism in neural growth course, is a kind of neurotrophic factor.Early stage at nervous system development, GABA can be used as a kind of chemical signal, first motion that affects the nerves, the migration of stimulating neuronal.GABA is especially synthetic larger with the organelle impact of transhipment AQP-CHIP on relating on some organelles, therefore GABA can promote the synthetic of AQP-CHIP, comprises the synthetic of GABA acceptor and some neural GAP-associated protein GAPs and enzyme.GABA also has certain regulating action to the expression of some neural GAP-associated protein GAPs and enzyme.
Fruit of Chinese magnoliavine taste acid, sweet, warm in nature, has the function of astringent or styptic treatment for spontaneous sweating, the nourishing generate fluid of convergence, kidney calming.Fruit of Chinese magnoliavine ethanol extract, fructus schisandrae water extract all can make mouse autonomic activities obviously reduce, and can strengthen maincenter tranquilizer chlorpromazine and the inhibitory action of reserpine to autonomic activities, the excitation of antagonism central stimulant amphetamine to autonomic activities.Schizandrin is one of main active ingredient in magnolia vine fruit kernel ethanol extract.What schizandrin inhibition mouse was caused by electro photoluminescence or long-term Dan Ju enrages behavior, to rat avoidance conditioned reflex and the selective inhibition syngignoscism of the conditioned reflex of second order.Chinese magnoliavine fruit super fine powder decocting liquid, schisandra fruit decoction, fructus schisandrae water extract and active ingredient schizandrin A thereof, the third element, alcohol the second grade all can increase the dosage pentobarbital sodium in mice sleep number of elements of sleeping under threshold, extend the dosage pentobarbital sodium in mice length of one's sleep of above threshold sleeping.Wherein second element and ester second first extend on having the length of one's sleep of mouse the two-phase impact of shortening afterwards.Fructus Schisandrae Chinensis volatile oil can obviously shorten the mouse sleep time that yellow Jackets cause, but with central stimulant pentylenetetrazole and strychnine without synergy.When Fructus Schisandrae Chinensis volatile oil dosage is 1.24g/kg and 0.71g/kg, can causes the movable minimizing of mouse, and can significantly increase liver cell cytochrome P-450 content.Therefore, Fructus Schisandrae Chinensis volatile oil there is no central excitation effect, and its mechanism that shortens yellow Jackets lengths of one's sleep of causing is relevant to liver drug enzyme inducing action with it, but not direct effect to central nervous system.
Calcium is a kind of inorganic salts that people's in-vivo content is maximum, and to safeguarding the health of body, what guarantee normal growth was grown has important function smoothly.Calcium can promote the activity of some enzyme in body, the active function of regulatory enzyme; Participate in nerve, the activity of muscle and the release of neurotransmitter; Regulate the secretion of hormone.The contraction movement of the solidifying of blood, cell adherence, muscle also all needs calcium.Calcium also tool regulates the rhythm of the heart, reduces cardiovascular permeability, controls inflammation and oedema, maintains the effects such as acid-base balance.Calcium can reduce the excitability of nerve cell, is a kind of natural sedative.Calcium deficiency can cause nervous migraine (accounting for women's 10%-20%), dysphoria, insomnia.
Magnesium is the interior cation of cell that is only second to potassium in human body, and its participates in a series of metabolic processes in body, comprises the formation of bone and cell, has substantial connection with neuromuscular and cardiac function.Under the synergy of magnesium, calcium can make N&M reduce excitability, and in blood, magnesium is too low or calcium is too low, and excitability all increases; Otherwise there is sedation.
Cobastab
6to maintain the necessary material of nervous system normal function, can more effective mood placating.
Another object of the present invention is to provide a kind of preparation that improves sleep, and described preparation comprises described health-care food composition and pharmaceutically acceptable auxiliary material.
Wherein, described preparation is solid pharmaceutical preparation or liquid preparation, and described solid pharmaceutical preparation is tablet, capsule, pulvis or soft capsule; Described liquid preparation is oral liquid.
Wherein, described auxiliary material is pharmaceutically acceptable carrier or diluent.
Wherein, described pharmaceutically acceptable auxiliary material is one or more in xylitol, D-sorbite, isomalt, isomaltoketose, mannitol, starch, dextrin, water, microcrystalline cellulose, lactose, HPMC, soybean oil, phosphatide, dolomol.
Wherein, described water is preferably purified water.
Wherein, described auxiliary material is conventional amount used.That is, described preparation is on the formula basis of described health-care food composition, and the auxiliary material containing is 10-50 part.Preferably, described auxiliary material is 30-40 part.Most preferably, described auxiliary material is 40 parts.
Wherein, if described preparation is oral liquid, in described auxiliary material, the consumption of water is 1600-3200 part.Preferably, in described auxiliary material, the consumption of water is 2000-3000 part, and most preferably, in described auxiliary material, the consumption of water is 2000 parts.
Another object of the present invention is to provide the preparation method of the preparation of described improvement sleep, and described method is for taking in proportion GABA powder, Schisandra chinens P.E, calcium containing compound, magnesium-containing compound, Cobastab
6, sieve, add pharmaceutically acceptable auxiliary material, mix, be prepared into conventional formulation.
Health-care food composition and the preparation of improvement sleep of the present invention have the following advantages:
The health-care food composition of improvement sleep of the present invention and preparation are with GABA powder, Schisandra chinens P.E, calcium containing compound, magnesium-containing compound and Cobastab
6for main component, not containing hypnotic composition, can effectively releive high pressure crowd and dyssomnia person's mood, improves sleep.
Detailed description of the invention
Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Raw material GABA powder of the present invention is 20 type GABA powder (GABA mass content is 20%), purchased from Shanghai Tong Yuan food technology Co., Ltd;
Schisandra chinens P.E is water extract, brown fine powder, and withdrawal ratio is 5:1, purchased from Jiahe, Shaanxi bio tech ltd;
The present invention's other each raw materials used are commercially available prod;
If do not specialize, the conventional means that in embodiment, technological means used is well known to those skilled in the art.
Embodiment 1 capsule
1, prescription (weight): GABA powder 800g, Schisandra chinens P.E 80g, magnesia (containing magnesium 60%) 500g, calcium carbonate (calcic 40%) 500g, Cobastab
61g, hydroxypropyl methylcellulose 600g, dolomol 400g, specification 600mg/ grain.
2, preparation method:
1) take GABA powder, Schisandra chinens P.E, magnesia, calcium carbonate, Cobastab according to prescription
6, hydroxypropyl methylcellulose and dolomol, cross respectively 40 mesh sieves, for subsequent use;
2) above-mentioned supplementary material is mixed by the equivalent method of progressively increasing, pour in capsule-filling mould filling capsule, polishing, packing into.
3, specification: contain GABA 0.033g, Schisandra chinens P.E 0.017g, magnesium 0.0625g, calcium 0.042g, Cobastab in every capsules
60.21mg.
4, taking dose: take 2 every day.
Embodiment 2 tablets
1, prescription (weight): GABA powder 1200g, Schisandra chinens P.E 300g, magnesium gluconate (containing magnesium 5.39%) 2000g, calcium lactate (calcic 13%) 1000g, Cobastab
68g, lactose 2000g, xylitol 1500g, dextrin 500g, microcrystalline cellulose 800g, specification 1.0g/ sheet.
2, preparation method:
1) take GABA powder, Schisandra chinens P.E, magnesium gluconate, calcium lactate, Cobastab according to prescription
6, lactose, xylitol, microcrystalline cellulose, dextrin cross respectively 80 mesh sieves, for subsequent use;
2) above-mentioned supplementary material (except microcrystalline cellulose, dextrin) is mixed by the equivalent method of progressively increasing, make water as adhesive, softwood processed, the oscillating granulator granulation by above-mentioned softwood through 14 eye mesh screens, particle is inserted in multi-functional boiling drier, 50 DEG C of fluidized dryings approximately 40 minutes, control pellet moisture 5%, whole grain, then in particle, add microcrystalline cellulose, dextrin, total mixed, compressing tablet, packing;
3, specification: every contains Schisandra chinens P.E 0.032g containing GABA 0.026g, containing magnesium 0.012g, calcic 0.014g, Cobastab
60.86mg.
4, taking dose: take 2 every day.
Embodiment 3 pulvis
1, prescription (weight): GABA powder 900g, Schisandra chinens P.E 100g, magnesium lactate (containing magnesium 8%) 800g, calcium citrate (calcic 21%) 600g, Cobastab
65g, isomalt 1200g, isomaltoketose 1000g, mannitol 2800g, specification 2g/ bag.
2, preparation method:
1) claim GABA powder, Schisandra chinens P.E, magnesium lactate, calcium citrate, Cobastab according to prescription
6, isomalt, mannitol, isomaltoketose cross respectively 40 mesh sieves, for subsequent use;
2) above-mentioned supplementary material is mixed to packing by the equivalent method of progressively increasing.
3, specification: every bag containing GABA 0.049g, Schisandra chinens P.E 0.027g, magnesium 0.017g, calcium 0.034g, Cobastab
61.35mg.
4, taking dose: take 1 bag every day.
Embodiment 4 soft capsules
1, prescription (weight): GABA powder 2000g, Schisandra chinens P.E 800g, magnesium glycinate (containing magnesium 12.6%) 1000g, calcium glycine (calcic 21%) 1500g, Cobastab
610g, soybean oil 1200g, phosphatidase 13 00g, specification 0.5g/ grain.
2, preparation method:
1) take GABA powder, Schisandra chinens P.E, magnesium glycinate, calcium glycine, Cobastab according to prescription
6, cross respectively 100 mesh sieves, for subsequent use;
2) above-mentioned supplementary material is mixed by the equivalent method of progressively increasing, then with soybean oil, phosphatide homogeneous, with automatic rotation Zhanang machine, pressing moulding.
3, specification: contain GABA 0.029g, Schisandra chinens P.E 0.059g, magnesium 0.009g, calcium 0.023g, Cobastab in every 1 soft capsule
60.73mg.
4, taking dose: take 1 every day.
Embodiment 5 oral liquids
1, prescription (weight): GABA powder 4000g, Schisandra chinens P.E 200g, magnesium chloride (containing magnesium 12%) 1500g, calcium carbonate (calcic 40%) 2000g, Cobastab
6100g, D-sorbite 3000g, purified water 200000ml, specification 10ml/ props up.
2, preparation method:
1) take GABA powder, Schisandra chinens P.E, magnesium chloride, calcium carbonate, Cobastab according to prescription
6, D-sorbite, respectively cross 80 mesh sieves, for subsequent use;
2) above-mentioned supplementary material is all dissolved in 200000ml purified water, then stirs, filling, to obtain final product.
3, specification: contain GABA 0.04g, Schisandra chinens P.E 0.01g, magnesium 0.009g, calcium 0.04g, Cobastab in every 1 oral liquid
60.005g.
4, taking dose: take 1 every day.
Embodiment 6 capsules
1, prescription (weight): GABA powder 2500g, Schisandra chinens P.E 500g, magnesium sulfate (containing magnesium 9.9%) 1200g, calcium gluconae (calcic 9%) 1200g, Cobastab
650g, hydroxypropyl methylcellulose 2700g, dolomol 1000g, starch 300g, specification 600mg/ grain.
2, preparation method:
1) take GABA powder, Schisandra chinens P.E, magnesium sulfate, calcium gluconae, Cobastab according to prescription
6, hydroxypropyl methylcellulose, starch, dolomol, cross respectively 40 mesh sieves, for subsequent use;
2) above-mentioned supplementary material is mixed by the equivalent method of progressively increasing, pour in capsule-filling mould filling capsule, polishing, packing into.
3, specification: contain GABA 0.032g, Schisandra chinens P.E 0.032g, magnesium 0.008g, calcium 0.007g, Cobastab in every capsules
63.2mg.
4, taking dose: take 2 every day.
Experimental example
1 materials and methods
1.1 test specimens and grouping
Experiment is divided into 6 groups, be designated as respectively control group, experimental group 1, experimental group 2, experimental group 3, experimental group 4, experimental group 5, the product that experimental group 1-5 makes taking the embodiment of the present invention 1,2,3,5,6 is respectively test specimen administration, the product administration that control group makes with patent CN102133331A.
1.2 animal used as test
Kunming mouse, 18-22g, male and female half and half, are provided by Chinese Academy of Sciences animal.
1.3 test dose designs
Experiment is divided into 6 groups, every morning 8:00-9:00 gastric infusion, and animal ad lib and drinking-water, ensure that the suitable temperature of feeding environment is 24 ± 5 DEG C, relative humidity 40-70%, noiselessness.
1.4 experimental technique
1.4.1 the mouse hypnosis test of threshold dose and the induction of sub-threshold dose yellow Jackets
Adopt male mice successive administration 2 weeks, 15min after last administration, threshold dose animal is by 35mg/kg dosage lumbar injection yellow Jackets (capacity is 0.1ml/10g), sub-threshold dose animal is by 22mg/kg dosage lumbar injection yellow Jackets (injection volume is 0.1ml/10g), reach 1min as sleep index taking mouse righting reflex loss, observe mouse to the prolongation effect of the length of one's sleep of threshold dose yellow Jackets, and on inducing the impact that sleep number of animals occurs in 30min after the administration of sub-threshold dose yellow Jackets.
1.4.2 barbital sodium hypnosis test
Select female mice, gavage 2 weeks continuously, 15min after last administration, each group mouse is by 300mg/kg dosage lumbar injection barbital sodium (injection volume is 0.1ml/10g), reach 1min using mouse righting reflex loss above as the criterion of falling asleep, observe the incubation period to each group mouse starts sleep after barbital sodium.
1.5 statistical method
Measurement data adopts variance analysis, and enumeration data adopts X
2inspection.
2 results
2.1 general behaviors are learned and are observed
Give after given the test agent, respectively organize mouse and show the behavior such as peace and quiet, autonomic activities minimizing, but do not observe the direct syngignoscism of tested material to mouse.
The mouse hypnosis test of 2.2 threshold doses and the induction of sub-threshold dose yellow Jackets
Different given the test agent is as shown in table 1 on the impact of yellow Jackets inducing mouse hypnosis time and sleep incidence.
The impact of table 1 on the yellow Jackets inducing mouse length of one's sleep and sleep incidence
# represents each experimental group and control group comparison, has significant difference, P<0.05; * represent each experimental group and control group comparison, have utmost point significant difference, P<0.01.
As seen from Table 1; each experimental group all can obviously extend the mouse sleep time of threshold dose yellow Jackets induction; test 1 group, test 2 groups, test 4 groups and control group comparison; significant difference (P<0.05); test 3 groups and 5 groups of experiments and control group comparison, difference is (P<0.01) extremely significantly; Meanwhile, each experimental group is increased significantly sub-threshold dose yellow Jackets inducing mouse sleep incidence, tests 1 group and control group comparison, significant difference (P<0.05); Other experimental group and control group comparison, difference is (P<0.01) extremely significantly.
2.3 barbital sodium hypnosis tests
Different given the test agent on barbital sodium inducing mouse Sleep latency to affect result as shown in table 2.
The impact of table 2 on barbital sodium inducing mouse Sleep latency
As seen from Table 2, experimental group 1, experimental group 4 and control group comparison, can obviously shorten barbital sodium inducing mouse Sleep latency, significant difference (P<0.05); Other experimental group and control group comparison, can extremely obviously shorten barbital sodium inducing mouse Sleep latency, and difference is (P<0.01) extremely significantly.
3 conclusions
From whole experimentation, improvement of the present invention sleep composition and preparation thereof are to the mouse sleep effect that improves significantly.
In sum, the health-care food composition of improvement sleep of the present invention and preparation are with GABA powder, Schisandra chinens P.E, calcium containing compound, magnesium-containing compound and Cobastab
6for main component, not containing hypnotic composition, can effectively releive high pressure crowd and dyssomnia person's mood, improves sleep.
Although, above use general explanation, detailed description of the invention and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (6)
1. one kind is improved the health-care food composition of sleep, it is characterized in that, described health-care food composition is made up of the raw material of following weight portion: GABA powder 12-25 part, Schisandra chinens P.E 1-5 part, calcium containing compound 10-15 part, magnesium-containing compound 10-15 part, Cobastab
60.1-0.5 part;
Described GABA powder is 20 type GABA powder, and the mass content of its GABA is 20%;
Described Schisandra chinens P.E is water extract, and its withdrawal ratio is 5:1;
Described calcium containing compound is selected from one or more in calcium carbonate, calcium gluconae, calcium citrate, calcium lactate, calcium glycine; The described magnesium compound that contains is selected from one or more in magnesium sulfate, magnesium gluconate, magnesia, magnesium chloride, magnesium lactate, magnesium glycinate.
2. want the health-care food composition described in 1 according to right, it is characterized in that, described health-care food composition is made up of the raw material of following weight portion: 25 parts, GABA powder, 5 parts of Schisandra chinens P.Es, 12 parts of calcium containing compounds, 12 parts of magnesium-containing compounds, Cobastab
60.5 part.
3. a preparation that improves sleep, is characterized in that, described preparation comprises health-care food composition and the pharmaceutically acceptable auxiliary material described in claim 1 or 2.
4. preparation according to claim 3, is characterized in that, described preparation is solid pharmaceutical preparation or liquid preparation, and described solid pharmaceutical preparation is tablet, capsule, pulvis or soft capsule; Described liquid preparation is oral liquid.
5. preparation according to claim 3, it is characterized in that, described pharmaceutically acceptable auxiliary material is one or more in xylitol, D-sorbite, isomalt, isomaltoketose, mannitol, starch, dextrin, water, microcrystalline cellulose, lactose, HPMC, soybean oil, phosphatide, dolomol.
6. prepare the method for improving sleep preparation described in claim 3-5 any one, it is characterized in that, described method is for taking in proportion GABA powder, Schisandra chinens P.E, calcium containing compound, magnesium-containing compound, Cobastab
6, sieve, add pharmaceutically acceptable auxiliary material, mix, be prepared into conventional formulation.
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