CN106036877A - Nutritional compound for improving sleep and application thereof - Google Patents

Abstract

The invention discloses a nutritional composition for improving sleep, which comprises zinc, calcium, magnesium, VB6, VC, L-tryptophan, VD, VE, jujube seed, lily, and schisandra; The sleep-improving components of the source plants work together to promote the metabolism of the human body and regulate the microcirculation of the human body, eliminate restlessness, shorten the time of waking up and falling asleep before going to bed, have the effects of calming the mind, calming the soul, and nourishing the mind, and then play a role in improving sleep. effect. The realization of the above functions is directly related to the selection of components, the compatibility relationship between components and the ratio of dosage. Because of the complexity of the central nervous system, safety research is very important. In addition to activity research, it is also necessary Analyze its safety, such as addiction, whether there are adverse effects on learning and memory, etc. The functional food of the present invention is obtained through systematic screening, analysis and comparison to obtain the above-mentioned optimal raw materials and proportions, not through simple superposition.

Description

Nutritional composition for improving sleep and its application

technical field

The invention relates to the field of health food, in particular to a nutritional composition for improving sleep and application thereof.

Background technique

Sleep is a spontaneous and reversible resting state that occurs periodically in higher vertebrates, manifested as a decrease in the body's response to external stimuli and a temporary interruption of consciousness. About 1/3 of a person's life is spent in sleep. When people are in a sleep state, the brain and body can be rested, rested and recovered, which is helpful for people's daily work and study. Scientifically improving sleep quality is the guarantee for people's normal work, study and life. Sleep disorders have caused a considerable number of people to be in a "sub-healthy" state. Sleep disorders often cause low immunity and mental irritability, and also easily lead to high blood pressure, neurasthenia, cardiovascular and cerebrovascular accidents, and psychological disorders, and even sudden death. The threat that sleep disorder brings to daily work and life is also very terrible. According to statistics, 30-50% of accidents are caused by drowsiness. According to a five-and-a-half-year study by two American scholars on 7,000 people, sleep is an important one among the seven factors that affect human lifespan. Sleep disorders can also cause a large amount of economic losses. According to a survey by the American Institute of Sleep Disorders, the economic losses caused by sleep disorders in the United States amount to 43 to 56 billion U.S. dollars a year. Commonly used drugs for the treatment of sleep disorders include chemosynthetic and natural drugs. Chemosynthetic drugs include barbiturates, benzodiazepines, and non-benzodiazepine short-acting drugs. These drugs have definite curative effects, but they are addictive and Adverse reactions such as rebound insomnia are serious. my country is rich in resources of Chinese herbal medicines, among which there are a large number of Chinese herbal medicines that can be used to treat insomnia and improve sleep quality. Selecting suitable Chinese herbal medicines for combination can not only improve the internal circulation of the human body, effectively improve people's sleep quality, but also the Chinese herbal medicines have low toxic and side effects and are not easy to produce dependence. At present, there are also some Chinese herbal medicines for treating insomnia and improving sleep quality on the market, but the formula of these Chinese herbal medicines is unreasonable, the product is rough, the effect of improving sleep quality is poor, and the production process is complicated, and the price is relatively expensive.

Contents of the invention

In view of this, the purpose of the present invention is to provide a nutritional composition for improving sleep and its application, which uses the synergy of supplementing trace elements and sleep-improving ingredients of medicinal and edible plants to promote the metabolism of the human body and regulate the microcirculation of the human body , Eliminate irritability, shorten the time of waking up and falling asleep before going to bed, have the effects of calming the mind, calming the soul, and rejuvenating the mind, and then play a role in improving sleep.

The nutritional composition for improving sleep of the present invention comprises the following components:

15～25mg zinc, 1000～1500mg calcium, 350～700mg magnesium, 50～100mg VB6, 1～2g VC, 1～3gL-tryptophan, 20～50ug VD, 300～500mg VE, 10～20g jujube seed, 10 ～30g lily, 10～15g schisandra;

Further, the following components are included:

18～25mg zinc, 1200～1400mg calcium, 440～650mg magnesium, 60～100mg VB6, 1～2g VC, 1～3gL-tryptophan, 25～45ug VD, 380～500mg VE, 12～18g jujube seed, 15 ～25g lily, 12～15g schisandra.

Further, the following components are included:

20mg zinc, 1300mg calcium, 500mg magnesium, 80mg VB6, 1.5g VC, 2g L-tryptophan, 35ug VD, 400mgVE, 15g jujube seed, 20g lily, 13g schisandra.

Furthermore, pharmaceutically, nutraceutical, and food acceptable carriers can be added to make preparations.

The application of the sleep-improving nutritional composition of the present invention in the preparation of sleep-improving medicines, health care products and food.

Beneficial effects of the present invention: supplementing trace elements and synergizing with the sleep-improving ingredients of medicinal and edible plants can promote the metabolism of the human body and regulate the microcirculation of the human body, eliminate restlessness, shorten the time of awakening and falling asleep before going to bed, and have the effect of calming the mind. It has the effect of calming the soul and rejuvenating the mind, and then plays a role in improving sleep. The realization of the above functions is directly related to the selection of components, the compatibility relationship between components and the ratio of dosage. Because of the complexity of the central nervous system, safety research is very important. In addition to activity research, it is also necessary Analyze its safety, such as addiction, whether there are adverse effects on learning and memory, etc. The functional food of the present invention is obtained through systematic screening, analysis and comparison to obtain the above-mentioned optimal raw materials and proportions, not through simple superposition.

Zinc: As an essential trace element for the human body, zinc is a component and/or agonist of many important enzymes in the body, participates in the metabolism of various substances in the body, and plays an important role in anti-oxidation, anti-inflammation, immune regulation, regulation of cell replication and differentiation, hormone play an important role in secretion and growth and development. Sleep disorders can cause changes in body behavior, cognition, emotion, endocrine, neurotransmitters, and immune functions, and zinc can improve the above symptoms.

Calcium: As the most abundant mineral element in the human body, it is an important part of the skeleton and maintains the normal growth and development of the body; in addition, calcium participates in regulating the release of various hormones and neurotransmitters, and has the effect of regulating muscle and nerve excitability. Calcium deficiency can lead to increased neuromuscular excitability and affect sleep.

Magnesium: As a constant element in the human body, it is an activator of various enzymes, participates in more than 300 kinds of enzymatic reactions, and has a regulating effect on the synthesis and decomposition of sugar, fat, and protein, energy metabolism, and excitability of nerves and muscles. In addition, cell membrane potential is controlled by magnesium levels, which in this way control the uptake and release of neurotransmitters such as dopamine, serotonin, and GABA that regulate sleep function.

VB6: With its active form PLP (pyridoxal phosphate) as the coenzyme of many enzymes, it participates in the metabolism of neurotransmitters, carbohydrates, sphingomyelin, heme, fat and nucleic acids, and participates in all amino acid metabolism. In addition, studies have shown that vitamin B6 can improve the activity of antioxidant enzymes in the body and reduce lipid peroxides, thereby protecting the body from free radical damage. Sleep disorders can lead to excessive oxidative stress in the body. The mechanism may be through neurohumoral Oxidative stress response of the body is induced by the reaction, energy consumption metabolism and increase of free radicals, reduction of the body's antioxidant capacity, and endoplasmic reticulum stress. VC and VE are important antioxidant substances in the body and have a synergistic effect.

VC: As an electron donor, it has anti-oxidation and is also a strong reducing agent. It is a cofactor necessary to maintain the activity of hydroxylase in the body, and participates in the synthesis and metabolism of many important substances in the body, such as collagen, 5-hydroxytryptamine, and norepinephrine. In addition, it also has the functions of detoxification and improving the body's resistance

L-tryptophan: Tryptophan can be converted into 5-hydroxytryptamine (5-HT) in the human body, and it is the only substance that can be converted into 5-HT in the brain. 5-HT can be used as a neurotransmitter in the brain, which is closely related to the state of excitation and inhibition of the nervous system. The decrease of 5-HT can cause sleep dysfunction. In the brain, 5-HT can also be converted into melatonin (5-methoxy-N-acetyltryptamine). Melatonin has the effect of promoting natural sleep induction. Therefore, the metabolites of tryptophan can balance the mind and improve sleep quality, and can be used for depression, anxiety, insomnia and other diseases.

VE: The main physiological function is anti-oxidation, and it is the most important fat-soluble antioxidant and free radical scavenger in the body. It mainly resists the free radicals produced by peroxidation on the biological membrane, protects the structure and function of the biological membrane, and maintains the normal fluidity of the cell membrane. Phenol free radicals, the latter can be reduced under the action of VC or glutathione to call the non-free radical product tocopherol. VE can regulate the expression of a variety of genes, such as genes related to tocopherol metabolism, genes related to the development of atherosclerosis, genes related to cell adhesion and anti-inflammation, genes related to cell signal transduction and cell cycle regulation, etc. Therefore, VE has multiple functions other than anti-oxidation, such as anti-inflammation, maintaining normal immune function, inhibiting cell proliferation, preventing atherosclerosis, and anti-aging.

Suanzaoren: It is the dry and mature seed of Ziziphus jujuba, a plant of Rhamnaceae. It is sweet and flat in nature and taste, and has the effects of nourishing the liver, calming the heart, calming the nerves, and suppressing sweat. It is a commonly used nourishing heart in the treatment of insomnia in traditional Chinese medicine. Tranquilizer. Jujube kernel mainly contains three mushrooms, flavonoids, fatty oil and other bioactive components. Pharmacological experiments have confirmed that flavonoids and saponins mainly act on the central nervous system, which can inhibit the central nervous system and have a sedative effect. The mechanism of action may be achieved by reducing monoamine neurotransmitters in the brain.

Lily: sweet, slightly bitter, slightly cold in nature, homecoming, lung meridian, has the power of nourishing yin and moistening lung, clearing heart and calming nerves. It is used to treat chronic cough due to yin deficiency, restlessness due to deficiency, and insomnia. It mainly contains polysaccharides, saponins, alkaloids, phospholipids and other compounds. Modern pharmacological studies have shown that lilyin in lily has sedative and hypnotic effects. The rate of sleep was significantly improved with sodium-bital. In addition, lily also has functions such as enhancing the body's resistance and anti-cancer.

Schisandra chinensis: warm in nature, sour and sweet in taste, has the effects of astringing and astringent, nourishing qi and promoting body fluid, nourishing kidney and calming heart. It is often used to treat diseases such as chronic cough, shortness of breath, nocturnal emission, enuresis, frequent urination, chronic diarrhea, spontaneous perspiration, night sweats, neurasthenia, hepatitis, etc. Schisandra chinensis also contains biologically active components such as lignans, polysaccharides and volatile oils. Modern pharmacological studies have confirmed that both schisandra chinensis extracts and schisandrin A can reduce the autonomous activity of mice and prolong the sleep duration of mice induced by barbiturates. The lipid components have significant sedative and sleep-improving effects.

Fushen can also be added to cooperate with pentobarbital sodium to exert an inhibitory effect on the central system, passion flower can be added to improve anxiety, and night vine and black water valerian can also be added to improve sleep. , the content of 5-HT; add gardenia yellow pigment, docosahexaenoic acid-phospholipid (DHA-PC), white peony root, etc. to improve sleep, and the addition amount of the above components is 2-4g.

detailed description

Embodiment one

The nutritional composition for improving sleep of the present embodiment comprises the following components:

15mg zinc, 1000mg calcium, 350mg magnesium, 50mg VB6, 1g VC, 1g L-tryptophan, 20ug VD, 300mg VE, 10g jujube seed, 10g lily, 10g schisandra.

Embodiment two

The nutritional composition for improving sleep of the present embodiment comprises the following components:

25mg zinc, 1500mg calcium, 700mg magnesium, 100mg VB6, 2g VC, 3g L-tryptophan, 50ug VD, 500mg VE, 20g jujube seed, 30g lily, 15g schisandra.

Embodiment Three

The nutritional composition for improving sleep of the present embodiment comprises the following components:

18mg zinc, 1200mg calcium, 440mg magnesium, 60mg VB6, 1g VC, 1g L-tryptophan, 25ug VD, 380mg VE, 12g jujube seed, 15g lily, 12g schisandra.

Embodiment four

The nutritional composition for improving sleep of the present embodiment comprises the following components:

25mg zinc, 1400mg calcium, 650mg magnesium, 100mg VB6, 2g VC, 3g L-tryptophan, 45ug VD, 500mg VE, 18g jujube seed, 25g lily, 15g schisandra.

Embodiment five

The nutritional composition for improving sleep of the present embodiment comprises the following components:

18mg zinc, 1400mg calcium, 440mg magnesium, 100mg VB6, 1g VC, 3g L-tryptophan, 25ug VD, 500mg VE, 12g jujube seed, 25g lily, 12g schisandra.

Embodiment six

The nutritional composition for improving sleep of the present embodiment comprises the following components:

20mg zinc, 1300mg calcium, 500mg magnesium, 80mg VB6, 1.5g VC, 2g L-tryptophan, 35ug VD, 400mgVE, 15g jujube seed, 20g lily, 13g schisandra.

Embodiment seven

The nutritional composition for improving sleep of the present embodiment comprises the following components:

18mg Zinc, 1200mg Calcium, 650mg Magnesium, 100mg VB6, 1g VC, 1g L-Tryptophan, 45ug VD, 500mg VE, 12g Jujube Seed, 15g Lily, 15g Schisandra, 2g Fushen, 2g Passion Flower Improve Anxiety, 2g Night cross vine, 2g black water valerian, 2g gardenia yellow pigment, 2g docosahexaenoic acid-phospholipid (DHA-PC), 2g white peony root.

Embodiment Eight

The nutritional composition for improving sleep of the present embodiment comprises the following components:

25mg Zinc, 1000mg Calcium, 700mg Magnesium, 50mg VB6, 2g VC, 1g L-Tryptophan, 50ug VD, 300mg VE, 20g Jujube Seed, 10g Lily, 15g Schisandra, 2g Fushen, 4g Passiflora Improve Anxiety, 4g Gardenia yellow pigment, 4g docosahexaenoic acid-phospholipid (DHA-PC).

Embodiment nine

The nutritional composition for improving sleep of the present embodiment comprises the following components:

25mg zinc, 1500mg calcium, 700mg magnesium, 50mg VB6, 1g VC, 1g L-tryptophan, 50ug VD, 300mg VE, 20g jujube seed, 10g lily, 15g schisandra, 3g Fushen, 2g passion flower, black water 3g gardenia yellow pigment, 3g white peony.

Add the sleep-improving nutritional composition of the above examples to a medically or food- or health-care acceptable carrier to make a preparation, which can be prepared into a suitable dosage form by adding any excipients used in this field. The auxiliary materials include but are not limited to disintegrants, fillers, lubricants, wetting agents, solubilizers, cosolvents, emulsifiers, colorants, adhesives, osmotic pressure, regulators, stabilizers, glidants, Flavoring agent, preservative, suspending agent, coating material, fragrance, anti-adhesive agent, antioxidant, antioxidant synergist, chelating agent, penetration enhancer, pH regulator, plasticizer, surfactant , foaming agent, defoaming agent, thickener, inclusion agent, humectant, absorbent, diluent, flocculant and deflocculant, filter aid, etc.

Application of the nutritional composition for improving sleep in the preparation of food, health products and medicines for improving sleep.

Experimental example:

100 people suffering from insomnia were selected as an example, the age range was 14-62 years old, 45 were male and 55 were female, and the course of treatment was 2 months. Each person takes the product of Example 1 of the present invention once a day. The effect judgment standard is:

Significant effect: the sleep time returns to normal, or the sleep time at night is more than 6 hours, the sleep is deep, and the energy is energetic after waking up;

Effective: the sleep is obviously improved or reduced, the sleep time is increased by more than 3 hours, and the sleep depth is increased;

Invalid: no improvement in insomnia.

Through the two-month follow-up investigation, the data listed in Table 1 below are obtained:

Effect of the present invention

According to the above data, the effective rate of the nutritional composition for improving sleep of the present invention reaches 95%.

Finally, it is noted that the above embodiments are only used to illustrate the technical solutions of the present invention without limitation. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be carried out Modifications or equivalent replacements without departing from the spirit and scope of the technical solution of the present invention shall be covered by the claims of the present invention.

Claims (5)

1. the nutritional composition improving sleep, it is characterised in that: include following components:

15～25mg zinc, 1000～1500mg calcium, 350～700mg magnesium, 50～100mg VB6,1～2g VC, 1～3g L-color Propylhomoserin, 20～50ug VD, 300～500mg VE, 10～20g Semen Ziziphi Spinosae, 10～30g Bulbus Lilii, 10～15g Fructus Schisandrae Chinensis.

The nutritional composition improving sleep the most according to claim 1, it is characterised in that: include following components:

18～25mg zinc, 1200～1400mg calcium, 440～650mg magnesium, 60～100mg VB6,1～2g VC, 1～3g L-color Propylhomoserin, 25～45ug VD, 380～500mg VE, 12～18g Semen Ziziphi Spinosae, 15～25g Bulbus Lilii, 12～15g Fructus Schisandrae Chinensis.

The nutritional composition improving sleep the most according to claim 2, it is characterised in that: include following components:

20mg zinc, 1300mg calcium, 500mg magnesium, 80mg VB6,1.5g VC, 2g L-Trp, 35ug VD, 400mg VE, 15g Semen Ziziphi Spinosae, 20g Bulbus Lilii, 13g Fructus Schisandrae Chinensis.

4. according to the nutritional composition improving sleep described in claim 1-3 any claim, it is characterised in that: can add Enter the carrier that can accept in pharmacy, health care conduct and learning, bromatology and make preparation.

5. improve sleep according to the nutritional composition improving sleep described in claim 1-3 any claim in preparation Application on medicine, health product, food.