CN102805871A - Material of soybean polysaccharide hollow capsule and production method of capsule - Google Patents
Material of soybean polysaccharide hollow capsule and production method of capsule Download PDFInfo
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Abstract
The invention provides a material of a soybean polysaccharide hollow capsule, and aims to solve the problems of poor friability and poor disintegration existing in the conventional hollow capsule. According to the technical scheme of the invention, the material comprises the following components in percentage by weight: 32-42 percent of soybean polysaccharides, 45-54 percent of pulullan polysaccharides, 2-10 percent of a humectant and 4-8 percent of a gel. The soybean polysaccharide hollow capsule is prepared from the material by the following steps of: a, fully mixing all components, adding water, mixing and stirring uniformly; b, putting a mixture obtained by stirring uniformly in the step a into a water bath for dissolving, removing air bubbles, cooling in a water bath, and preserving heat for 30-40 minutes to obtain a colloid; and c, dipping glue, drying, cutting and combining to obtain the soybean polysaccharide hollow capsule. The hollow capsule prepared by taking the material as a raw material has high friability and high disintegration, and the quality of the hollow capsule is not reduced if the hollow capsule is preserved for a long time.
Description
Technical field
The present invention is specifically related to a kind of material and capsular production method of Capsules, particularly a kind of material of soybean polysaccharide body Capsules and capsular production method.
Background technology
At present; Capsules comprises that the main component of hard capsule and soft capsule is a gelatin; Its production technology mainly is to utilize the skin from animal, the gelatin that bone extracts, and adds some plasticizers, edible pigment and opacifier and process gelatin solution, and the reuse mould dips in glue, solidify, dry and form.This capsule by manufacturing of gelatin behind the filling medicine owing to gelatin contain animal proteinum be subject to environmental change and in the composition influence of powder charge thing, defective such as existence is prone to become fragile, degeneration, disintegration exceed standard.And because gelatin is to extract from the skin of some animal, the people of faith Islam, kosher can't eat, because bovine spongiform encephalopathy, foot and mouth disease is popular, causes gelatin security hidden trouble to occur.
The patent of domestic applications plant hollow capsule is many at present; Chinese patent prospectus CN1483393 (a kind of starch Capsules wherein; It is characterized in that; Said starch Capsules is made up of components such as plant amylum or starch derivatives, plasticizer, water; The percentage by weight of said plant amylum or starch derivatives, plasticizer, water is plant amylum or starch derivatives 25%-94.9%, plasticizer 0.1%-30%, water 5%-20%), CN1623529A (a kind of compositions of making Capsules; The compositions key component mass content that it is characterized in that described Capsules is following: a kind of compositions of making Capsules is characterized in that the compositions key component mass content of described Capsules is following: 2000 parts of pure water, 300～420 parts of potato starch; 10～20 parts of carrageenans), CN1739488A (a kind of method for preparing of composite hollow konjaku capsule; It is characterized in that: Rhizoma amorphophalli glucomannan is through hydrochloric acidolysis and hydrogen peroxide oxidation modification, adds vegetable protein or animal gelatin polymerization and generates composite high-molecular, through colloidal sol, be incubated, dip in glue, drying and releasing process process and make composite hollow konjaku capsule; And the raw material weight percentage ratio of preparation composite hollow konjaku capsule is: acid hydrolysis oxidative Rhizoma amorphophalli glucomannan 3.5～31.5%, vegetable protein or animal gelatin or isinglass 3.5～31.5%; Glycerol 0.2～0.6%, dodecane sulfonate 0.01～0.07%, food coloring 0.01～0.03%; Ethyl hydroxybenzoate 0.01～0.03%, all the other are water, and make solid content reach 20～35%); They use starch or modified starch etc. to be major ingredient, are equipped with various adjuvants, have solved some problem of gelatin.But their shortcoming is common, and promptly friability is not very desirable, and friability is bad, just influences probability on Capsules production and the filling machine.
Other one type is to be primary raw material with the water-soluble cellulose, and like CN1418081A, CN1329478A, CN1202102A or the like, their common feature is to be raw material with the water-soluble cellulose or derivatives thereof; It is not pure natural prodcuts, these cellulosicss, but its poor mobile performance, disintegration are unstable; And cost is high, is difficult to adapt to mechanization filling medicine, and after long preservation; Occur yellowing and the phenomenon of sending out mist easily, not only outward appearance is not attractive in appearance, and its inherent quality descends to some extent.
The capsular patent of simple pulullan polysaccharide empty also has, and for example (a kind of pullulan polysaccharide hollow hard capasule is characterized in that patent No. CN101069677A; Comprise following component and percentage by weight: pulullan polysaccharide 58～96%; Gel 0～10%, flocculation aid 0～2%, surfactant 0～5%; Wetting agent 0～5%, surplus are aequum moisture; Said gel is one or more in carrageenan, agar, pectin, the sodium alginate; Said flocculation aid is one or more in potassium chloride, calcium chloride, potassium phosphate, the potassium citrate; Said surfactant is one or more in dodecyl sodium sulfate, Tween 80, the span; Said wetting agent is one or more in glycerol, dimethicone, the Oleum Ricini).The pulullan polysaccharide empty capsule in the mensuration of friability, though meet the requirement of Chinese Pharmacopoeia Capsules,, can not reach the pharmaceutical factory requirement.Concerning the pharmaceutical factory, damaged all is unacceptable 1%, because; Medicine or the health product of wanting the recipient plant Capsules to fill; Price general charged all is that comparison is expensive, in the time of last machine, all need go up probability 100%; Reduce the loss of powder filler, the damaged accumulation 1% will produce enormous economic loss.
Therefore, need a kind of plant hollow capsule, can separate the shortcoming of cassia gum Capsules, also should have good friability index, disintegration index, and low price are convenient to long preservation.
Summary of the invention
An object of the present invention is to provide a kind of material of soybean polysaccharide body Capsules; Use this kind material to solve the problem that prior art occurs as the Capsules of feedstock production; Its capsule friability, disintegration are good; Yellowing and the phenomenon of sending out mist can not appear after the long preservation, appearance looks elegant, and its inherent quality can not descend.
Another object of the present invention is to adopt the production method of the material preparation Capsules of above-mentioned soybean polysaccharide body Capsules.
The present invention's technical scheme that adopts of dealing with problems is:
The present invention provides a kind of material of soybean polysaccharide body Capsules, includes solid material and fluent material; Be under 100% the situation with said solid material weight: include soybean polysaccharide body 32----42%, pulullan polysaccharide 45---54%, wetting agent 2----10%, gel 4---8% according to this solid material of percentage by weight; Said fluent material is a water.
Wherein preferred viscosities is the soybean polysaccharide body of 10----100cps.
Wherein preferred molecular weight is 50,000---80 ten thousand pulullan polysaccharide.
Wherein wetting agent is selected from polyvinyl alcohol 0588, polyvinyl alcohol 1788, polyvinyl alcohol 2488, pharmaceutical grade glycerol, pharmaceutical grade dimethicone.
In the specific embodiment of the present invention, said gel is selected from gellan gum, κ type carrageenan, ι type carrageenan, β type carrageenan, agar, pectin, sodium alginate, xanthan gum, Konjac glucomannan, POLY-karaya, locust bean gum, Furcellaran, tamarind gum, tara gum, scleroglucan, microbial alginate, carbomer or its combination.More preferably κ type carrageenan.
In fluent material, add in addition flocculation aid in another specific embodiment of the present invention, flocculation aid in fluent material content be 0---0.05% (w/v).
Preferably, said flocculation aid is selected from following flocculation aid: potassium chloride, calcium chloride, potassium phosphate, potassium citrate or its combination.
More preferably, flocculation aid is a potassium chloride.
The present invention also provides a kind of production method of soybean polysaccharide body Capsules, may further comprise the steps:
A, get soybean polysaccharide body 32----42% by weight percentage, pulullan polysaccharide 45---54%, wetting agent 2----10%, gel 4---8% after all the components fully mixed, adds the water mixing and stirring;
B, the mixture that stirs in the step 1 is placed 80 ℃ of-90 ℃ of water-baths dissolving and eliminates bubble, water-bath cools to 50 ℃-52 ℃, becomes colloid in 30-40 minute 50 ℃-52 ℃ insulations;
C, dip in glue then, oven dry, cutting, fit promptly obtain soybean polysaccharide body Capsules;
Its whole process of production keeps room temperature at 20-22 ℃.
The present invention also provides a kind of production method of soybean polysaccharide body Capsules in addition, may further comprise the steps:
A, get soybean polysaccharide body 32----42%, pulullan polysaccharide 45---54%, wetting agent 2----10% by weight percentage; Gel 4---8% adds the water mixing and stirring, adds flocculation aid again; The content of flocculation aid in water is 0---0.05%, with the abundant mixing and stirring of all the components;
B, the mixture that stirs among the step a is placed 80 ℃ of-90 ℃ of water-baths dissolving and eliminates bubble, water-bath cools to 50 ℃-52 ℃, becomes colloid in 30-40 minute 50 ℃-52 ℃ insulations;
C, dip in glue then, oven dry, cutting, fit promptly obtain soybean polysaccharide body Capsules;
Its whole process of production keeps room temperature at 20-22 ℃.
Beneficial effect of the present invention:
The soybean polysaccharide body be from Semen sojae atricolor, refine make by the molecular Powdered polysaccharose substance of galactose, arabinose, galactobionic acid Galactonic acid, rhamnose, trehalose, xylose and glucose five equilibrium.Adopt the soybean polysaccharide body to replace gelatin among the present invention, various crowds can both be eaten, the edible hidden danger of having avoided some Animal diseases to bring simultaneously.
2. through evidence, it is the Capsules of feedstock production that its friability of Capsules that adopts the soybean polysaccharide system to be equipped with is better than with other plant class such as plant amylum or starch derivatives, water-soluble cellulose or derivatives thereof, can not influence medicine and fill.Simultaneously because the chemical property of water-soluble cellulose itself, with the water-soluble cellulose phenomenon that a yellowing and a mist appear after long time stored in the Capsules of feedstock production easily, not only outward appearance is not attractive in appearance, and capsular inherent quality can not descend to some extent.Adopting the soybean polysaccharide body among the present invention is the feedstock production Capsules, can avoid producing the problems referred to above.
3. the soybean polysaccharide body is from Semen sojae atricolor, to refine to make, and is the pure natural plant raw material, and is harmless.And plant amylum or starch derivatives, water-soluble cellulose or derivatives thereof etc. are not pure natural plant raw material.
The specific embodiment
The present invention provides a kind of material of soybean polysaccharide body Capsules, includes soybean polysaccharide body 32----42%, pulullan polysaccharide 45---54%, wetting agent 2----10%, gel 4---8% according to this material of percentage by weight.
Wherein preferred viscosities is the soybean polysaccharide body of 10----100cps.
Wherein preferred molecular weight is 50,000---80 ten thousand pulullan polysaccharide.
Wherein wetting agent is selected from polyvinyl alcohol 0588, polyvinyl alcohol 1788, polyvinyl alcohol 2488, pharmaceutical grade glycerol, pharmaceutical grade dimethicone.
Said gel selects gellan gum, κ type carrageenan, ι type carrageenan, β type carrageenan, agar, pectin, sodium alginate, xanthan gum, Konjac glucomannan, POLY-karaya, locust bean gum, Furcellaran, tamarind gum, tara gum, scleroglucan, microbial alginate, carbomer or its combination, more preferably κ type carrageenan.
In fluent material, add in addition flocculation aid among the present invention, flocculation aid in fluent material content be 0---0.05% (w/v).
Preferably, said flocculation aid is selected from following flocculation aid: potassium chloride, calcium chloride, potassium phosphate, potassium citrate or its combination.
More preferably, flocculation aid is a potassium chloride.
Below the various compositions of soybean polysaccharide body Capsules material of the present invention are described respectively.
The soybean polysaccharide body
The soybean polysaccharide body is to be raw material with the Semen sojae atricolor, through technologies such as defat, extraction, separation, purification, sterilization, drying process by the molecular Powdered polysaccharose substance of galactose, arabinose, galactobionic acid Galactonic acid, rhamnose, trehalose, xylose and glucose five equilibrium.The soybean polysaccharide body contains the dietary fiber greater than 65%, has the same intestinal physiology function of general water soluble dietary fiber.The soybean polysaccharide body is soluble among the hot water or cold water, can prepare to surpass 10% aqueous solution, and gelatin phenomenon can not occur.The solution viscosity of soybean polysaccharide body is low, and is heat-resisting, acidproof, and inorganic salt does not have influence basically to it, has advantages of higher stability.Preferred viscosities is the soybean polysaccharide body of 10----100cps among the present invention.
Pulullan polysaccharide
Pulullan polysaccharide is a kind of similar glucosan that is produced by Aureobasidium pullulans fermentation, the outer water solublity cement polysaccharide of born of the same parents of xanthan gum, and it is a kind of special microbial polysaccharide of being found by R.Bauer in 1938.This polysaccharide is by α-1; The maltotriose recurring unit that 4 glycosidic bonds connect is through α-1; The straight chain shape polysaccharide that 6 glycosidic bonds are polymerized, molecular weight be between 4.8x10～2.2x10 (commodity pulullan polysaccharide mean molecule quantity 2x105. approximately is made up of 480 maltotrioses) generally.This polysaccharide has two important characteristics: high resilience on the structure, dissolubility is bigger.The film property of pulullan polysaccharide, gas barrier property, plasticity, viscosity are all stronger, and have good characteristics such as soluble in water, nontoxic, colorless and odorless, have been widely used in fields such as medicine, food, light industry, chemical industry and oil.Preferred molecular weight is 50,000 among the present invention---80 ten thousand pulullan polysaccharide.
Wetting agent
Because the Pharmacopoeia of the People's Republic of China has requirement to the friability of Capsules, and must keep moisture just can make its friability reach requirement in the Capsules, therefore add wetting agent in the present invention.Said wetting agent is selected from polyvinyl alcohol 0588, polyvinyl alcohol 1788, polyvinyl alcohol 2488, pharmaceutical grade glycerol, pharmaceutical grade dimethicone.
Gel
Gellan gum, κ type carrageenan, ι type carrageenan, β type carrageenan, agar, pectin, sodium alginate, xanthan gum, Konjac glucomannan, POLY-karaya, locust bean gum, Furcellaran, tamarind gum, tara gum, scleroglucan, microbial alginate, carbomer or its combination.Preferred κ type carrageenan.
Flocculation aid
Sometimes the glue gel time prolongs, and Capsules thickness is not reached evenly, therefore can suitably increase flocculation aid, and flocculation aid is selected from potassium chloride, calcium chloride, potassium phosphate, potassium citrate or its combination among the present invention, preferred potassium chloride.
Except said components, soybean polysaccharide body Capsules of the present invention can also add other additives as required, and for example pigment, flavoring agent, surfactant adjuvants such as (dodecyl sodium sulfates), these adjuvants all are adjuvants commonly used in the prior art.The not special restriction of said other components of additives, only otherwise the object of the invention is produced restriction to get final product.
The present invention also provides a kind of production method of soybean polysaccharide body Capsules, may further comprise the steps:
A, get soybean polysaccharide body 32----42% by weight percentage, pulullan polysaccharide 45---54%, wetting agent 2----10%, gel 4---8% after all the components fully mixed, adds the water mixing and stirring;
B, the mixture that stirs among the step a is placed 80 ℃ of-90 ℃ of water-baths dissolving and eliminates bubble, water-bath cools to 50 ℃-52 ℃, becomes colloid in 30-40 minute 50 ℃-52 ℃ insulations;
C, dip in glue then, oven dry, cutting, fit promptly obtain soybean polysaccharide body Capsules;
Its whole process of production keeps room temperature at 20-22 ℃.
In the specific embodiment of the production method of soybean polysaccharide body Capsules of the present invention, may further comprise the steps:
A, get soybean polysaccharide body 32----42%, pulullan polysaccharide 45---54%, wetting agent 2----10% by weight percentage; Gel 4---8% adds the water mixing and stirring, adds flocculation aid again; The content of flocculation aid in water is 0---0.05%, with the abundant mixing and stirring of all the components;
B, the mixture that stirs among the step a is placed 80 ℃ of-90 ℃ of water-baths dissolving and eliminates bubble, water-bath cools to 50 ℃-52 ℃, becomes colloid in 30-40 minute 50 ℃-52 ℃ insulations;
C, dip in glue then, oven dry, cutting, fit promptly obtain soybean polysaccharide body Capsules;
Its whole process of production keeps room temperature at 2022 ℃.
Embodiment 1
Specific operation process is following:
A, above-mentioned each solid constituent fully mixed after, add the water mixing and stirring;
B, the mixture that stirs among the step a is placed 90 ℃ of water-baths dissolving and eliminates bubble, water-bath cools to 50 ℃, becomes colloid in 30 minutes 50 ℃ of insulations;
C, dip in glue then, oven dry, cutting, fit promptly obtain soybean polysaccharide body Capsules;
Its whole process of production keeps room temperature at 20 ℃-22 ℃.
The above-mentioned soybean polysaccharide body Capsules that makes is made an experiment according to the regulation to gelatin Capsules friability and disintegration in the Pharmacopoeia of the People's Republic of China.
Result: friability; 50 soybean polysaccharide body Capsuleses do not have breakage.Be 15 minutes disintegration.
Embodiment 2
Specific operation process is following:
A, above-mentioned each solid constituent fully mixed after, add the water mixing and stirring;
B, the mixture that stirs among the step a is placed 85 ℃ of water-baths dissolving and eliminates bubble, water-bath cools to 52 ℃, becomes colloid in 35 minutes 52 ℃ of insulations;
C, dip in glue then, oven dry, cutting, fit promptly obtain soybean polysaccharide body Capsules;
Its whole process of production keeps room temperature at 20 ℃-22 ℃.
The above-mentioned soybean polysaccharide body Capsules that makes is made an experiment according to the regulation to gelatin Capsules friability and disintegration in the Pharmacopoeia of the People's Republic of China.
Result: friability; 50 soybean polysaccharide body Capsuleses do not have breakage.Be 13 minutes disintegration.
Embodiment 3
Specific operation process is following:
A, above-mentioned each solid constituent fully mixed after, add the water mixing and stirring;
B, the mixture that stirs among the step a is placed 90 ℃ of water-baths dissolving and eliminates bubble, water-bath cools to 50 ℃, becomes colloid in 40 minutes 50 ℃ of insulations;
C, dip in glue then, oven dry, cutting, fit promptly obtain soybean polysaccharide body Capsules;
Its whole process of production keeps room temperature at 20-22 ℃.
The above-mentioned soybean polysaccharide body Capsules that makes is made an experiment according to the regulation to gelatin Capsules friability and disintegration in the Pharmacopoeia of the People's Republic of China.
Result: friability; 50 soybean polysaccharide body Capsuleses do not have breakage.Be 15 minutes disintegration.
Embodiment 4
Specific operation process is following:
A, above-mentioned each solid constituent fully mixed after, add the water mixing and stirring;
B, the mixture that stirs among the step a is placed 89 ℃ of water-baths dissolving and eliminates bubble, water-bath cools to 50 ℃, becomes colloid in 32 minutes 50 ℃ of insulations;
C, dip in glue then, oven dry, cutting, fit promptly obtain soybean polysaccharide body Capsules;
Its whole process of production keeps room temperature at 20-22 ℃.
The above-mentioned soybean polysaccharide body Capsules that makes is made an experiment according to the regulation to gelatin Capsules friability and disintegration in the Pharmacopoeia of the People's Republic of China.
Result: friability; 50 soybean polysaccharide body Capsuleses do not have breakage.Be 13 minutes disintegration.
Embodiment 5
Specific operation process is following:
A, above-mentioned each solid constituent fully mixed after, add the water mixing and stirring;
B, the mixture that stirs among the step a is placed 88 ℃ of water-baths dissolving and eliminates bubble, water-bath cools to 51 ℃, becomes colloid in 34 minutes 51 ℃ of insulations;
C, dip in glue then, oven dry, cutting, fit promptly obtain soybean polysaccharide body Capsules;
Its whole process of production keeps room temperature at 20-22 ℃.
The above-mentioned soybean polysaccharide body Capsules that makes is made an experiment according to the regulation to gelatin Capsules friability and disintegration in the Pharmacopoeia of the People's Republic of China.
Result: friability; 50 soybean polysaccharide body Capsuleses have 5 breakages.Be 14 minutes disintegration.
Embodiment 6
Specific operation process is following:
A, above-mentioned each solid constituent fully mixed after, add the water mixing and stirring;
B, the mixture that stirs among the step a is placed 87 ℃ of water-baths dissolving and eliminates bubble, water-bath cools to 51 ℃, becomes colloid in 38 minutes 51 ℃ of insulations;
C, dip in glue then, oven dry, cutting, fit promptly obtain soybean polysaccharide body Capsules;
Its whole process of production keeps room temperature at 20-22 ℃.
The above-mentioned soybean polysaccharide body Capsules that makes is made an experiment according to the regulation to gelatin Capsules friability and disintegration in the Pharmacopoeia of the People's Republic of China.
Result: friability; 50 soybean polysaccharide body Capsuleses do not have breakage.Be 15 minutes disintegration.
Embodiment 7
Specific operation process is following:
A, above-mentioned each solid constituent fully mixed after, add the water mixing and stirring;
B, the mixture that stirs among the step a is placed 86 ℃ of water-baths dissolving and eliminates bubble, water-bath cools to 51 ℃, becomes colloid in 30 minutes 51 ℃ of insulations;
C, dip in glue then, oven dry, cutting, fit promptly obtain soybean polysaccharide body Capsules;
Its whole process of production keeps room temperature at 20-22 ℃.
The above-mentioned soybean polysaccharide body Capsules that makes is made an experiment according to the regulation to gelatin Capsules friability and disintegration in the Pharmacopoeia of the People's Republic of China.
Result: friability; 50 soybean polysaccharide body Capsuleses do not have breakage.Be 13 minutes disintegration.
Embodiment 8
Specific operation process is following:
A, above-mentioned each solid constituent fully mixed after, add the water mixing and stirring;
B, the mixture that stirs among the step a is placed 87 ℃ of water-baths dissolving and eliminates bubble, water-bath cools to 552 ℃, becomes colloid in 32 minutes 52 ℃ of insulations;
C, dip in glue then, oven dry, cutting, fit promptly obtain soybean polysaccharide body Capsules;
Its whole process of production keeps room temperature at 20-22 ℃.
The above-mentioned soybean polysaccharide body Capsules that makes is made an experiment according to the regulation to gelatin Capsules friability and disintegration in the Pharmacopoeia of the People's Republic of China.
Result: friability; 50 soybean polysaccharide body Capsuleses have 3 breakages.Be 15 minutes disintegration.
Embodiment 9
Specific operation process is following:
A, above-mentioned each solid constituent fully mixed after, add the water mixing and stirring;
B, the mixture that stirs among the step a is placed 90 ℃ of water-baths dissolving and eliminates bubble, water-bath cools to 50 ℃, becomes colloid in 30 minutes 50 ℃ of insulations;
C, dip in glue then, oven dry, cutting, fit promptly obtain soybean polysaccharide body Capsules;
Its whole process of production keeps room temperature at 20-22 ℃.
The above-mentioned soybean polysaccharide body Capsules that makes is made an experiment according to the regulation to gelatin Capsules friability and disintegration in the Pharmacopoeia of the People's Republic of China.
Result: friability; 50 soybean polysaccharide body Capsuleses do not have breakage.Be 14 minutes disintegration.
Claims (10)
1. the material of soybean polysaccharide body Capsules is characterized in that: include solid material and fluent material; Be under 100% the situation with said solid material weight: include soybean polysaccharide body 32----42%, pulullan polysaccharide 45---54%, wetting agent 2----10%, gel 4---8% according to this solid material of percentage by weight; Said fluent material is a water.
2. the material of the soybean polysaccharide body Capsules described in claim 1, it is characterized in that: preferred viscosities is the soybean polysaccharide body of 10----100cps.
3. the material of the soybean polysaccharide body Capsules described in claim 1, it is characterized in that: preferred molecular weight is 50,000---80 ten thousand pulullan polysaccharide.
4. the material of the soybean polysaccharide body Capsules described in claim 1, it is characterized in that: said wetting agent is selected from polyvinyl alcohol 0588, polyvinyl alcohol 1788, polyvinyl alcohol 2488, pharmaceutical grade glycerol, pharmaceutical grade dimethicone.
5. the material of the soybean polysaccharide body Capsules described in claim 1; It is characterized in that: said gel is selected from gellan gum, κ type carrageenan, ι type carrageenan, β type carrageenan, agar, pectin, sodium alginate, xanthan gum, Konjac glucomannan, POLY-karaya, locust bean gum, Furcellaran, tamarind gum, tara gum, scleroglucan, microbial alginate, carbomer or its combination, preferred κ type carrageenan.
6. the material of the soybean polysaccharide body Capsules described in claim 1 is characterized in that: in fluent material, add flocculation aid in addition, flocculation aid in fluent material content be 0---0.05% (w/v).
7. the material of the soybean polysaccharide body Capsules described in claim 6, it is characterized in that: said flocculation aid is selected from potassium chloride, calcium chloride, potassium phosphate, potassium citrate or its combination.
8. the material of the soybean polysaccharide body Capsules described in claim 7 is characterized in that: the preferred potassium chloride of said flocculation aid.
9. the production method of soybean polysaccharide body Capsules is characterized in that: may further comprise the steps
A, get soybean polysaccharide body 32----42% by weight percentage, pulullan polysaccharide 45---54%, wetting agent 2----10%, gel 4---8% after all the components fully mixed, adds the water mixing and stirring;
B, the mixture that stirs among the step a is placed 85 ℃ of-90 ℃ of water-baths dissolving and eliminates bubble, water-bath cools to 50 ℃-52 ℃, becomes colloid in 30-40 minute 50 ℃-52 ℃ insulations;
C, dip in glue then, oven dry, cutting, fit promptly obtain soybean polysaccharide body Capsules;
Its whole process of production keeps room temperature at 20-22 ℃.
10. the production method of soybean polysaccharide body Capsules is characterized in that: may further comprise the steps
A, get soybean polysaccharide body 32----42%, pulullan polysaccharide 45---54%, wetting agent 2----10% by weight percentage; Gel 4---8% adds the water mixing and stirring, adds flocculation aid again; The content of flocculation aid in water is 0---0.05%, with the abundant mixing and stirring of all the components;
B, the mixture that stirs among the step a is placed 85 ℃ of-90 ℃ of water-baths dissolving and eliminates bubble, water-bath cools to 50 ℃-52 ℃, becomes colloid in 30-40 minute 50 ℃-52 ℃ insulations;
C, dip in glue then, oven dry, cutting, fit promptly obtain soybean polysaccharide body Capsules;
Its whole process of production keeps room temperature at 20-22 ℃.
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| WO2017197774A1 (en) * | 2016-05-19 | 2017-11-23 | 江苏力凡胶囊有限公司 | Film-forming composition, soft- and hard-shelled capsule manufactured using the composition, and manufacturing method thereof |
| CN108721632A (en) * | 2018-06-27 | 2018-11-02 | 中国海洋大学 | A kind of high molecular weight pullulan additive and its application in capsule preparation |
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| WO2017197774A1 (en) * | 2016-05-19 | 2017-11-23 | 江苏力凡胶囊有限公司 | Film-forming composition, soft- and hard-shelled capsule manufactured using the composition, and manufacturing method thereof |
| US10350568B2 (en) | 2016-05-19 | 2019-07-16 | Jiangsu Lefan Capsule Co., Ltd. | Membrane-forming composition, soft and hard capsules prepared based on this composition and the preparation methods |
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| CN108721632B (en) * | 2018-06-27 | 2021-10-22 | 中国海洋大学 | High molecular weight pullulan additive and application thereof in capsule preparation |
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