CN102027109B - 产生碳氢化合物的方法和组合物 - Google Patents
产生碳氢化合物的方法和组合物 Download PDFInfo
- Publication number
- CN102027109B CN102027109B CN200980117664.3A CN200980117664A CN102027109B CN 102027109 B CN102027109 B CN 102027109B CN 200980117664 A CN200980117664 A CN 200980117664A CN 102027109 B CN102027109 B CN 102027109B
- Authority
- CN
- China
- Prior art keywords
- aldehyde
- cell
- seqidno
- fatty alcohol
- alkanoic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims abstract description 132
- 229930195733 hydrocarbon Natural products 0.000 title abstract description 77
- 239000004215 Carbon black (E152) Substances 0.000 title abstract description 76
- 229920000642 polymer Polymers 0.000 title abstract description 73
- 239000000203 mixture Substances 0.000 title abstract description 34
- 125000001183 hydrocarbyl group Chemical group 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 200
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 192
- 229920001184 polypeptide Polymers 0.000 claims description 190
- 150000002191 fatty alcohols Chemical class 0.000 claims description 156
- 108090000623 proteins and genes Proteins 0.000 claims description 129
- -1 hexadecanyl aldehyde Chemical class 0.000 claims description 107
- 230000014509 gene expression Effects 0.000 claims description 83
- 229910052799 carbon Inorganic materials 0.000 claims description 58
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 54
- 108091033319 polynucleotide Proteins 0.000 claims description 38
- 102000040430 polynucleotide Human genes 0.000 claims description 38
- 239000002157 polynucleotide Substances 0.000 claims description 38
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 37
- FWWQKRXKHIRPJY-UHFFFAOYSA-N octadecanal Chemical compound CCCCCCCCCCCCCCCCCC=O FWWQKRXKHIRPJY-UHFFFAOYSA-N 0.000 claims description 35
- 230000000694 effects Effects 0.000 claims description 32
- 239000000284 extract Substances 0.000 claims description 32
- ZENZJGDPWWLORF-MDZDMXLPSA-N 9-Octadecenal Chemical compound CCCCCCCC\C=C\CCCCCCCC=O ZENZJGDPWWLORF-MDZDMXLPSA-N 0.000 claims description 29
- 239000013598 vector Substances 0.000 claims description 25
- UHUFTBALEZWWIH-UHFFFAOYSA-N tetradecanal Chemical compound CCCCCCCCCCCCCC=O UHUFTBALEZWWIH-UHFFFAOYSA-N 0.000 claims description 24
- 102000004316 Oxidoreductases Human genes 0.000 claims description 23
- 108090000854 Oxidoreductases Proteins 0.000 claims description 23
- GQEZCXVZFLOKMC-UHFFFAOYSA-N n-alpha-hexadecene Natural products CCCCCCCCCCCCCCC=C GQEZCXVZFLOKMC-UHFFFAOYSA-N 0.000 claims description 17
- HFDVRLIODXPAHB-UHFFFAOYSA-N 1-tetradecene Chemical compound CCCCCCCCCCCCC=C HFDVRLIODXPAHB-UHFFFAOYSA-N 0.000 claims description 10
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 claims description 10
- 229920006395 saturated elastomer Polymers 0.000 claims description 8
- 229960000541 cetyl alcohol Drugs 0.000 claims description 7
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 6
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims description 5
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims description 5
- 229940095068 tetradecene Drugs 0.000 claims description 5
- 235000021281 monounsaturated fatty acids Nutrition 0.000 claims description 4
- TZXFTUHLVMYUGE-UHFFFAOYSA-N 2-methyloctadecanal Chemical compound CCCCCCCCCCCCCCCCC(C)C=O TZXFTUHLVMYUGE-UHFFFAOYSA-N 0.000 claims description 3
- DIOQZVSQGTUSAI-UHFFFAOYSA-N n-butylhexane Natural products CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 claims description 2
- 238000004113 cell culture Methods 0.000 claims 2
- LQKRYVGRPXFFAV-UHFFFAOYSA-N Phenylmethylglycidic ester Chemical compound CCOC(=O)C1OC1(C)C1=CC=CC=C1 LQKRYVGRPXFFAV-UHFFFAOYSA-N 0.000 claims 1
- 150000001335 aliphatic alkanes Chemical class 0.000 abstract description 178
- 150000001336 alkenes Chemical class 0.000 abstract description 175
- 150000002430 hydrocarbons Chemical class 0.000 abstract description 76
- 239000002551 biofuel Substances 0.000 abstract description 25
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 401
- 150000001299 aldehydes Chemical class 0.000 description 174
- 241000894006 Bacteria Species 0.000 description 148
- 230000000968 intestinal effect Effects 0.000 description 118
- 241000192707 Synechococcus Species 0.000 description 105
- 102000004190 Enzymes Human genes 0.000 description 100
- 108090000790 Enzymes Proteins 0.000 description 100
- YCOZIPAWZNQLMR-UHFFFAOYSA-N pentadecane Chemical compound CCCCCCCCCCCCCCC YCOZIPAWZNQLMR-UHFFFAOYSA-N 0.000 description 86
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 85
- 235000014113 dietary fatty acids Nutrition 0.000 description 80
- 229930195729 fatty acid Natural products 0.000 description 80
- 239000000194 fatty acid Substances 0.000 description 80
- 125000003729 nucleotide group Chemical group 0.000 description 77
- 239000002773 nucleotide Substances 0.000 description 76
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 74
- 150000004665 fatty acids Chemical class 0.000 description 72
- 241000192700 Cyanobacteria Species 0.000 description 70
- 239000000758 substrate Substances 0.000 description 66
- 150000007523 nucleic acids Chemical class 0.000 description 61
- 238000006606 decarbonylation reaction Methods 0.000 description 60
- 230000006324 decarbonylation Effects 0.000 description 59
- 102000039446 nucleic acids Human genes 0.000 description 59
- 108020004707 nucleic acids Proteins 0.000 description 59
- 108020004414 DNA Proteins 0.000 description 58
- 239000000446 fuel Substances 0.000 description 49
- 230000001851 biosynthetic effect Effects 0.000 description 48
- 125000003275 alpha amino acid group Chemical group 0.000 description 45
- 239000002253 acid Substances 0.000 description 44
- 241000192656 Nostoc Species 0.000 description 43
- 241000588724 Escherichia coli Species 0.000 description 42
- 235000001014 amino acid Nutrition 0.000 description 40
- 239000003921 oil Substances 0.000 description 40
- 229940024606 amino acid Drugs 0.000 description 39
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 38
- 239000000126 substance Substances 0.000 description 38
- 230000015572 biosynthetic process Effects 0.000 description 35
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 34
- 150000002632 lipids Chemical class 0.000 description 34
- 239000000047 product Substances 0.000 description 34
- 241001478240 Coccus Species 0.000 description 33
- 150000001413 amino acids Chemical class 0.000 description 33
- 101100433719 Synechococcus elongatus (strain PCC 7942 / FACHB-805) Synpcc7942_1594 gene Proteins 0.000 description 30
- 230000001580 bacterial effect Effects 0.000 description 30
- 239000002609 medium Substances 0.000 description 30
- 230000002018 overexpression Effects 0.000 description 29
- IIYFAKIEWZDVMP-UHFFFAOYSA-N tridecane Chemical compound CCCCCCCCCCCCC IIYFAKIEWZDVMP-UHFFFAOYSA-N 0.000 description 28
- 125000002252 acyl group Chemical group 0.000 description 27
- 239000013604 expression vector Substances 0.000 description 27
- 238000004519 manufacturing process Methods 0.000 description 27
- 150000002148 esters Chemical class 0.000 description 26
- 239000012634 fragment Substances 0.000 description 24
- 239000000463 material Substances 0.000 description 22
- 231100000350 mutagenesis Toxicity 0.000 description 22
- 230000001502 supplementing effect Effects 0.000 description 22
- 101710146995 Acyl carrier protein Proteins 0.000 description 21
- 238000006243 chemical reaction Methods 0.000 description 21
- 150000002194 fatty esters Chemical class 0.000 description 21
- 238000002703 mutagenesis Methods 0.000 description 21
- 230000008859 change Effects 0.000 description 20
- 150000001875 compounds Chemical class 0.000 description 20
- NDJKXXJCMXVBJW-UHFFFAOYSA-N heptadecane Chemical compound CCCCCCCCCCCCCCCCC NDJKXXJCMXVBJW-UHFFFAOYSA-N 0.000 description 20
- 244000005700 microbiome Species 0.000 description 20
- 239000003208 petroleum Substances 0.000 description 20
- 230000003570 biosynthesizing effect Effects 0.000 description 19
- XEKOWRVHYACXOJ-UHFFFAOYSA-N ethyl acetate Substances CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 19
- 230000000670 limiting effect Effects 0.000 description 19
- 108020004705 Codon Proteins 0.000 description 18
- 230000006696 biosynthetic metabolic pathway Effects 0.000 description 18
- 230000008569 process Effects 0.000 description 17
- 102000004169 proteins and genes Human genes 0.000 description 17
- 108010074122 Ferredoxins Proteins 0.000 description 16
- 230000003321 amplification Effects 0.000 description 16
- 238000003199 nucleic acid amplification method Methods 0.000 description 16
- 235000018102 proteins Nutrition 0.000 description 16
- 230000009466 transformation Effects 0.000 description 16
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 15
- YWAKXRMUMFPDSH-UHFFFAOYSA-N pentene Chemical class CCCC=C YWAKXRMUMFPDSH-UHFFFAOYSA-N 0.000 description 15
- 239000000523 sample Substances 0.000 description 15
- 101100322942 Synechocystis sp. (strain PCC 6803 / Kazusa) sll0208 gene Proteins 0.000 description 14
- 102000005488 Thioesterase Human genes 0.000 description 14
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 description 14
- 239000010779 crude oil Substances 0.000 description 14
- 238000013467 fragmentation Methods 0.000 description 14
- 238000006062 fragmentation reaction Methods 0.000 description 14
- 238000001228 spectrum Methods 0.000 description 14
- 108020002982 thioesterase Proteins 0.000 description 14
- 241001464430 Cyanobacterium Species 0.000 description 13
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 13
- 125000000539 amino acid group Chemical group 0.000 description 13
- 239000008103 glucose Substances 0.000 description 13
- 239000012074 organic phase Substances 0.000 description 13
- 239000013612 plasmid Substances 0.000 description 13
- 238000003786 synthesis reaction Methods 0.000 description 13
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 12
- 230000008034 disappearance Effects 0.000 description 12
- 238000005516 engineering process Methods 0.000 description 12
- 239000002994 raw material Substances 0.000 description 12
- 210000002377 thylakoid Anatomy 0.000 description 12
- 241000219315 Spinacia Species 0.000 description 11
- 235000009337 Spinacia oleracea Nutrition 0.000 description 11
- 238000000855 fermentation Methods 0.000 description 11
- 230000004151 fermentation Effects 0.000 description 11
- 239000007788 liquid Substances 0.000 description 11
- 239000002028 Biomass Substances 0.000 description 10
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 10
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 10
- 230000004927 fusion Effects 0.000 description 10
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 10
- 239000006228 supernatant Substances 0.000 description 10
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 10
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 9
- 230000000295 complement effect Effects 0.000 description 9
- 239000002283 diesel fuel Substances 0.000 description 9
- 101150035981 fabH gene Proteins 0.000 description 9
- 230000012010 growth Effects 0.000 description 9
- 239000000314 lubricant Substances 0.000 description 9
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 9
- 230000002829 reductive effect Effects 0.000 description 9
- 239000002904 solvent Substances 0.000 description 9
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 8
- 101710192343 NADPH:adrenodoxin oxidoreductase, mitochondrial Proteins 0.000 description 8
- 102100036777 NADPH:adrenodoxin oxidoreductase, mitochondrial Human genes 0.000 description 8
- 108091028043 Nucleic acid sequence Proteins 0.000 description 8
- 101710104207 Probable NADPH:adrenodoxin oxidoreductase, mitochondrial Proteins 0.000 description 8
- 239000000654 additive Substances 0.000 description 8
- 230000000996 additive effect Effects 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 101150026389 fabF gene Proteins 0.000 description 8
- 239000002243 precursor Substances 0.000 description 8
- 238000011084 recovery Methods 0.000 description 8
- 230000009467 reduction Effects 0.000 description 8
- 101100012355 Bacillus anthracis fabH1 gene Proteins 0.000 description 7
- 101100012357 Bacillus subtilis (strain 168) fabHA gene Proteins 0.000 description 7
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 7
- 101710129019 Long-chain acyl-[acyl-carrier-protein] reductase Proteins 0.000 description 7
- 101100433720 Synechocystis sp. (strain PCC 6803 / Kazusa) sll0209 gene Proteins 0.000 description 7
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 7
- 239000004473 Threonine Substances 0.000 description 7
- 238000013459 approach Methods 0.000 description 7
- 238000006555 catalytic reaction Methods 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 239000003502 gasoline Substances 0.000 description 7
- 238000009396 hybridization Methods 0.000 description 7
- 230000006698 induction Effects 0.000 description 7
- 238000003780 insertion Methods 0.000 description 7
- 230000007246 mechanism Effects 0.000 description 7
- 239000012071 phase Substances 0.000 description 7
- 238000000746 purification Methods 0.000 description 7
- 238000000926 separation method Methods 0.000 description 7
- 239000013589 supplement Substances 0.000 description 7
- 238000001890 transfection Methods 0.000 description 7
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 7
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 6
- 241000193830 Bacillus <bacterium> Species 0.000 description 6
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 6
- 102000003960 Ligases Human genes 0.000 description 6
- 108090000364 Ligases Proteins 0.000 description 6
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 description 6
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 6
- 241000187747 Streptomyces Species 0.000 description 6
- 241000223259 Trichoderma Species 0.000 description 6
- 230000002378 acidificating effect Effects 0.000 description 6
- 125000003368 amide group Chemical group 0.000 description 6
- 125000003118 aryl group Chemical group 0.000 description 6
- 239000002131 composite material Substances 0.000 description 6
- 230000007613 environmental effect Effects 0.000 description 6
- 235000019439 ethyl acetate Nutrition 0.000 description 6
- 230000037431 insertion Effects 0.000 description 6
- 230000014759 maintenance of location Effects 0.000 description 6
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 description 6
- 210000004962 mammalian cell Anatomy 0.000 description 6
- 239000003550 marker Substances 0.000 description 6
- 108020004999 messenger RNA Proteins 0.000 description 6
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000011347 resin Substances 0.000 description 6
- 229920005989 resin Polymers 0.000 description 6
- 239000012064 sodium phosphate buffer Substances 0.000 description 6
- SIARJEKBADXQJG-LFZQUHGESA-N stearoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCCCCCCCCCCCCCCC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 SIARJEKBADXQJG-LFZQUHGESA-N 0.000 description 6
- 235000000346 sugar Nutrition 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 239000001993 wax Substances 0.000 description 6
- 241000228212 Aspergillus Species 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 241000238631 Hexapoda Species 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 5
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 5
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 5
- 101100322941 Synechococcus elongatus (strain PCC 7942 / FACHB-805) Synpcc7942_1593 gene Proteins 0.000 description 5
- 239000013543 active substance Substances 0.000 description 5
- 239000011324 bead Substances 0.000 description 5
- RTYJTGSCYUUYAL-YCAHSCEMSA-L carbenicillin disodium Chemical compound [Na+].[Na+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)C(C([O-])=O)C1=CC=CC=C1 RTYJTGSCYUUYAL-YCAHSCEMSA-L 0.000 description 5
- 150000001720 carbohydrates Chemical class 0.000 description 5
- 235000014633 carbohydrates Nutrition 0.000 description 5
- 230000010261 cell growth Effects 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 210000003527 eukaryotic cell Anatomy 0.000 description 5
- 108090001018 hexadecanal dehydrogenase (acylating) Proteins 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 229960000310 isoleucine Drugs 0.000 description 5
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 5
- 150000002576 ketones Chemical class 0.000 description 5
- 238000003808 methanol extraction Methods 0.000 description 5
- 229930182817 methionine Natural products 0.000 description 5
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 5
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- 239000007858 starting material Substances 0.000 description 5
- 239000004753 textile Substances 0.000 description 5
- 230000032258 transport Effects 0.000 description 5
- 241000251468 Actinopterygii Species 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 241000194107 Bacillus megaterium Species 0.000 description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 4
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 4
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 4
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 4
- XUYPXLNMDZIRQH-LURJTMIESA-N N-acetyl-L-methionine Chemical compound CSCC[C@@H](C(O)=O)NC(C)=O XUYPXLNMDZIRQH-LURJTMIESA-N 0.000 description 4
- 108091034117 Oligonucleotide Proteins 0.000 description 4
- 108020004511 Recombinant DNA Proteins 0.000 description 4
- 239000004902 Softening Agent Substances 0.000 description 4
- 241001655322 Streptomycetales Species 0.000 description 4
- 230000003213 activating effect Effects 0.000 description 4
- 229960000723 ampicillin Drugs 0.000 description 4
- 235000003704 aspartic acid Nutrition 0.000 description 4
- 238000007845 assembly PCR Methods 0.000 description 4
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 4
- 235000011089 carbon dioxide Nutrition 0.000 description 4
- 238000010367 cloning Methods 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 4
- 238000005336 cracking Methods 0.000 description 4
- 238000009795 derivation Methods 0.000 description 4
- 238000006911 enzymatic reaction Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 150000002185 fatty acyl-CoAs Chemical class 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 238000012239 gene modification Methods 0.000 description 4
- 230000002068 genetic effect Effects 0.000 description 4
- 230000005017 genetic modification Effects 0.000 description 4
- 235000013617 genetically modified food Nutrition 0.000 description 4
- 229960002989 glutamic acid Drugs 0.000 description 4
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 239000000543 intermediate Substances 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000035772 mutation Effects 0.000 description 4
- 235000020995 raw meat Nutrition 0.000 description 4
- 238000003259 recombinant expression Methods 0.000 description 4
- 238000002741 site-directed mutagenesis Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 241000894007 species Species 0.000 description 4
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
- 150000007970 thio esters Chemical class 0.000 description 4
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 4
- 101150046028 umuD gene Proteins 0.000 description 4
- 230000003612 virological effect Effects 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 210000005253 yeast cell Anatomy 0.000 description 4
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 241000186361 Actinobacteria <class> Species 0.000 description 3
- ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 description 3
- 241001513093 Aspergillus awamori Species 0.000 description 3
- 241001225321 Aspergillus fumigatus Species 0.000 description 3
- 241000351920 Aspergillus nidulans Species 0.000 description 3
- 241000228245 Aspergillus niger Species 0.000 description 3
- 240000006439 Aspergillus oryzae Species 0.000 description 3
- 235000002247 Aspergillus oryzae Nutrition 0.000 description 3
- 241000193744 Bacillus amyloliquefaciens Species 0.000 description 3
- 241000193752 Bacillus circulans Species 0.000 description 3
- 241000193749 Bacillus coagulans Species 0.000 description 3
- 241000193422 Bacillus lentus Species 0.000 description 3
- 241000194108 Bacillus licheniformis Species 0.000 description 3
- 241000194103 Bacillus pumilus Species 0.000 description 3
- 241000193388 Bacillus thuringiensis Species 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical class C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 108010088278 Branched-chain-amino-acid transaminase Proteins 0.000 description 3
- 241000193764 Brevibacillus brevis Species 0.000 description 3
- 102000053602 DNA Human genes 0.000 description 3
- 101710088194 Dehydrogenase Proteins 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 241000588722 Escherichia Species 0.000 description 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- 241000223218 Fusarium Species 0.000 description 3
- 241000223198 Humicola Species 0.000 description 3
- 241001480714 Humicola insolens Species 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 241000235649 Kluyveromyces Species 0.000 description 3
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 3
- 241000186660 Lactobacillus Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000235395 Mucor Species 0.000 description 3
- 241000221960 Neurospora Species 0.000 description 3
- 241000894763 Nostoc punctiforme PCC 73102 Species 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 241000228143 Penicillium Species 0.000 description 3
- 241000235648 Pichia Species 0.000 description 3
- 241000222350 Pleurotus Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 241000589516 Pseudomonas Species 0.000 description 3
- 241000235402 Rhizomucor Species 0.000 description 3
- 241000235403 Rhizomucor miehei Species 0.000 description 3
- 241000235346 Schizosaccharomyces Species 0.000 description 3
- 241000187432 Streptomyces coelicolor Species 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- 239000005864 Sulphur Substances 0.000 description 3
- 241000222354 Trametes Species 0.000 description 3
- 241000499912 Trichoderma reesei Species 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical group C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 229940054340 bacillus coagulans Drugs 0.000 description 3
- 229940097012 bacillus thuringiensis Drugs 0.000 description 3
- 230000000975 bioactive effect Effects 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 3
- 229910002091 carbon monoxide Inorganic materials 0.000 description 3
- 239000012159 carrier gas Substances 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 3
- 101150048956 coaA gene Proteins 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 125000004122 cyclic group Chemical group 0.000 description 3
- 238000013016 damping Methods 0.000 description 3
- 230000002950 deficient Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000009977 dual effect Effects 0.000 description 3
- 230000002255 enzymatic effect Effects 0.000 description 3
- 101150015067 fabB gene Proteins 0.000 description 3
- 239000010408 film Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000002538 fungal effect Effects 0.000 description 3
- 239000005431 greenhouse gas Substances 0.000 description 3
- 230000012447 hatching Effects 0.000 description 3
- 239000001307 helium Substances 0.000 description 3
- 229910052734 helium Inorganic materials 0.000 description 3
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 229940039696 lactobacillus Drugs 0.000 description 3
- 239000010687 lubricating oil Substances 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 231100000219 mutagenic Toxicity 0.000 description 3
- 230000003505 mutagenic effect Effects 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000003973 paint Substances 0.000 description 3
- 238000005192 partition Methods 0.000 description 3
- 239000002304 perfume Substances 0.000 description 3
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 230000010076 replication Effects 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 230000001568 sexual effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 238000013518 transcription Methods 0.000 description 3
- 230000035897 transcription Effects 0.000 description 3
- 101150115617 umuC gene Proteins 0.000 description 3
- 238000011144 upstream manufacturing Methods 0.000 description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 2
- 108010046716 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) Proteins 0.000 description 2
- 108700027273 Acyl Carrier Proteins 0.000 description 2
- 108700037654 Acyl carrier protein (ACP) Proteins 0.000 description 2
- 102000048456 Acyl carrier protein (ACP) Human genes 0.000 description 2
- 108010053754 Aldehyde reductase Proteins 0.000 description 2
- 102100027265 Aldo-keto reductase family 1 member B1 Human genes 0.000 description 2
- 241001328122 Bacillus clausii Species 0.000 description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 description 2
- 101100000756 Bacillus subtilis (strain 168) acpA gene Proteins 0.000 description 2
- 229920001342 Bakelite® Polymers 0.000 description 2
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
- 241000244203 Caenorhabditis elegans Species 0.000 description 2
- 108030002325 Carboxylate reductases Proteins 0.000 description 2
- 101100490145 Clostridium perfringens (strain 13 / Type A) ackA2 gene Proteins 0.000 description 2
- 108091033380 Coding strand Proteins 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 2
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 2
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 2
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- 239000004278 EU approved seasoning Substances 0.000 description 2
- 241000672609 Escherichia coli BL21 Species 0.000 description 2
- 101150071111 FADD gene Proteins 0.000 description 2
- 102000000476 Fatty Acid Transport Proteins Human genes 0.000 description 2
- 108010055870 Fatty Acid Transport Proteins Proteins 0.000 description 2
- 102000008857 Ferritin Human genes 0.000 description 2
- 108050000784 Ferritin Proteins 0.000 description 2
- 238000008416 Ferritin Methods 0.000 description 2
- 229930091371 Fructose Natural products 0.000 description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
- 239000005715 Fructose Substances 0.000 description 2
- 102000005720 Glutathione transferase Human genes 0.000 description 2
- 108010070675 Glutathione transferase Proteins 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 101000937642 Homo sapiens Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Proteins 0.000 description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
- 101100433987 Latilactobacillus sakei subsp. sakei (strain 23K) ackA1 gene Proteins 0.000 description 2
- 102100027329 Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Human genes 0.000 description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Natural products C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
- 101100412856 Mus musculus Rhod gene Proteins 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 101100462488 Phlebiopsis gigantea p2ox gene Proteins 0.000 description 2
- 241000589776 Pseudomonas putida Species 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
- 241000187561 Rhodococcus erythropolis Species 0.000 description 2
- 241001524101 Rhodococcus opacus Species 0.000 description 2
- 241000190932 Rhodopseudomonas Species 0.000 description 2
- 102000006382 Ribonucleases Human genes 0.000 description 2
- 108010083644 Ribonucleases Proteins 0.000 description 2
- 241000831652 Salinivibrio sharmensis Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 101100398785 Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) ldhD gene Proteins 0.000 description 2
- 244000057717 Streptococcus lactis Species 0.000 description 2
- 235000014897 Streptococcus lactis Nutrition 0.000 description 2
- 241000193998 Streptococcus pneumoniae Species 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 101100242191 Tetraodon nigroviridis rho gene Proteins 0.000 description 2
- 241000223258 Thermomyces lanuginosus Species 0.000 description 2
- 241000204673 Thermoplasma acidophilum Species 0.000 description 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
- 241000223261 Trichoderma viride Species 0.000 description 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
- 239000006035 Tryptophane Substances 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 101100386830 Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) ddh gene Proteins 0.000 description 2
- LPQOADBMXVRBNX-UHFFFAOYSA-N ac1ldcw0 Chemical compound Cl.C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 LPQOADBMXVRBNX-UHFFFAOYSA-N 0.000 description 2
- 101150070497 accC gene Proteins 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 101150006213 ackA gene Proteins 0.000 description 2
- 101150023061 acpP gene Proteins 0.000 description 2
- 101150051130 acpP1 gene Proteins 0.000 description 2
- 101150014383 adhE gene Proteins 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 150000001345 alkine derivatives Chemical class 0.000 description 2
- 150000004716 alpha keto acids Chemical class 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000000692 anti-sense effect Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 229940091771 aspergillus fumigatus Drugs 0.000 description 2
- 239000004637 bakelite Substances 0.000 description 2
- 238000009412 basement excavation Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 2
- 230000008827 biological function Effects 0.000 description 2
- 230000002051 biphasic effect Effects 0.000 description 2
- 150000001721 carbon Chemical class 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 230000003915 cell function Effects 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 101150094660 chcA gene Proteins 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- KFWWCMJSYSSPSK-PAXLJYGASA-N crotonoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)/C=C/C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 KFWWCMJSYSSPSK-PAXLJYGASA-N 0.000 description 2
- 150000001924 cycloalkanes Chemical class 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 229910052805 deuterium Inorganic materials 0.000 description 2
- 150000002016 disaccharides Chemical class 0.000 description 2
- 238000005553 drilling Methods 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 238000004043 dyeing Methods 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 150000002085 enols Chemical class 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 108010083294 ethanol acyltransferase Proteins 0.000 description 2
- 101150090981 fabG gene Proteins 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 235000011194 food seasoning agent Nutrition 0.000 description 2
- 235000021588 free fatty acids Nutrition 0.000 description 2
- 108091008053 gene clusters Proteins 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 150000003278 haem Chemical class 0.000 description 2
- PIYDVAYKYBWPPY-UHFFFAOYSA-N heptadecanal Chemical compound CCCCCCCCCCCCCCCCC=O PIYDVAYKYBWPPY-UHFFFAOYSA-N 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 238000007871 hydride transfer reaction Methods 0.000 description 2
- 238000005984 hydrogenation reaction Methods 0.000 description 2
- 150000002460 imidazoles Chemical class 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- XUWPJKDMEZSVTP-LTYMHZPRSA-N kalafungina Chemical group O=C1C2=C(O)C=CC=C2C(=O)C2=C1[C@@H](C)O[C@H]1[C@@H]2OC(=O)C1 XUWPJKDMEZSVTP-LTYMHZPRSA-N 0.000 description 2
- 229930027917 kanamycin Natural products 0.000 description 2
- 229960000318 kanamycin Drugs 0.000 description 2
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 2
- 229930182823 kanamycin A Natural products 0.000 description 2
- 101150026107 ldh1 gene Proteins 0.000 description 2
- 101150041530 ldha gene Proteins 0.000 description 2
- 239000003915 liquefied petroleum gas Substances 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 101150068528 mabA gene Proteins 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 238000010369 molecular cloning Methods 0.000 description 2
- 239000003471 mutagenic agent Substances 0.000 description 2
- 239000003345 natural gas Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000012038 nucleophile Substances 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 229920000098 polyolefin Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 101150060030 poxB gene Proteins 0.000 description 2
- 239000012460 protein solution Substances 0.000 description 2
- LEHBURLTIWGHEM-UHFFFAOYSA-N pyridinium chlorochromate Chemical compound [O-][Cr](Cl)(=O)=O.C1=CC=[NH+]C=C1 LEHBURLTIWGHEM-UHFFFAOYSA-N 0.000 description 2
- 238000012797 qualification Methods 0.000 description 2
- 239000011535 reaction buffer Substances 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 239000005060 rubber Substances 0.000 description 2
- 238000010079 rubber tapping Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 150000004671 saturated fatty acids Chemical class 0.000 description 2
- 101150108932 sll0209 gene Proteins 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- JXKPEJDQGNYQSM-UHFFFAOYSA-M sodium propionate Chemical compound [Na+].CCC([O-])=O JXKPEJDQGNYQSM-UHFFFAOYSA-M 0.000 description 2
- 239000004324 sodium propionate Substances 0.000 description 2
- 229960003212 sodium propionate Drugs 0.000 description 2
- 235000010334 sodium propionate Nutrition 0.000 description 2
- 230000000707 stereoselective effect Effects 0.000 description 2
- 239000004575 stone Substances 0.000 description 2
- 125000005480 straight-chain fatty acid group Chemical group 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 101150087812 tesA gene Proteins 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 229960004799 tryptophan Drugs 0.000 description 2
- 210000003501 vero cell Anatomy 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 230000003313 weakening effect Effects 0.000 description 2
- 210000002268 wool Anatomy 0.000 description 2
- 239000004711 α-olefin Substances 0.000 description 2
- NWXMGUDVXFXRIG-WESIUVDSSA-N (4s,4as,5as,6s,12ar)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O NWXMGUDVXFXRIG-WESIUVDSSA-N 0.000 description 1
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 1
- IZFHEQBZOYJLPK-SSDOTTSWSA-N (R)-dihydrolipoic acid Chemical compound OC(=O)CCCC[C@@H](S)CCS IZFHEQBZOYJLPK-SSDOTTSWSA-N 0.000 description 1
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 description 1
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- KNKRKFALVUDBJE-UHFFFAOYSA-N 1,2-dichloropropane Chemical compound CC(Cl)CCl KNKRKFALVUDBJE-UHFFFAOYSA-N 0.000 description 1
- MXHRCPNRJAMMIM-SHYZEUOFSA-N 2'-deoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-SHYZEUOFSA-N 0.000 description 1
- CKTSBUTUHBMZGZ-SHYZEUOFSA-N 2'‐deoxycytidine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 CKTSBUTUHBMZGZ-SHYZEUOFSA-N 0.000 description 1
- LRWZZZWJMFNZIK-UHFFFAOYSA-N 2-chloro-3-methyloxirane Chemical compound CC1OC1Cl LRWZZZWJMFNZIK-UHFFFAOYSA-N 0.000 description 1
- 241000007910 Acaryochloris marina Species 0.000 description 1
- 101100230376 Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) celI gene Proteins 0.000 description 1
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 description 1
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 108700016155 Acyl transferases Proteins 0.000 description 1
- 102000057234 Acyl transferases Human genes 0.000 description 1
- 101710104255 Acyl-CoA wax alcohol acyltransferase 2 Proteins 0.000 description 1
- 102100027841 Acyl-CoA wax alcohol acyltransferase 2 Human genes 0.000 description 1
- 102100024396 Adrenodoxin, mitochondrial Human genes 0.000 description 1
- 101710119622 Adrenodoxin, mitochondrial Proteins 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 206010001497 Agitation Diseases 0.000 description 1
- 101710153593 Albumin A Proteins 0.000 description 1
- 101100214752 Arabidopsis thaliana ABCG12 gene Proteins 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 241000892910 Aspergillus foetidus Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 108010018763 Biotin carboxylase Proteins 0.000 description 1
- 101000984722 Bos taurus Pancreatic trypsin inhibitor Proteins 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 229920000324 Cellulosome Polymers 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241000123346 Chrysosporium Species 0.000 description 1
- 241000699802 Cricetulus griseus Species 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241000252867 Cupriavidus metallidurans Species 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 241000702421 Dependoparvovirus Species 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 101100296146 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) pab1 gene Proteins 0.000 description 1
- 241000305071 Enterobacterales Species 0.000 description 1
- 102100029727 Enteropeptidase Human genes 0.000 description 1
- 108010013369 Enteropeptidase Proteins 0.000 description 1
- 101100481529 Escherichia phage N15 gene 18 gene Proteins 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 108060002716 Exonuclease Proteins 0.000 description 1
- 101710088939 Ferredoxin-1 Proteins 0.000 description 1
- 101710088935 Ferredoxin-2 Proteins 0.000 description 1
- 102100026117 Ferredoxin-2, mitochondrial Human genes 0.000 description 1
- 101710088940 Ferredoxin-3 Proteins 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 108700028146 Genetic Enhancer Elements Proteins 0.000 description 1
- 241000193385 Geobacillus stearothermophilus Species 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
- 241000701109 Human adenovirus 2 Species 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 description 1
- VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical group CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 description 1
- 108030005217 Isobutyryl-CoA mutases Proteins 0.000 description 1
- 108090000769 Isomerases Proteins 0.000 description 1
- 102000004195 Isomerases Human genes 0.000 description 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 101100393312 Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM 00102 / Lb 14) gpsA1 gene Proteins 0.000 description 1
- 240000008415 Lactuca sativa Species 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 1
- 101100391545 Mus musculus Fxyd3 gene Proteins 0.000 description 1
- 241000187480 Mycobacterium smegmatis Species 0.000 description 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
- 241000424623 Nostoc punctiforme Species 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical class CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 241001520808 Panicum virgatum Species 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 108091093037 Peptide nucleic acid Proteins 0.000 description 1
- 241000222385 Phanerochaete Species 0.000 description 1
- 101001135788 Pinus taeda (+)-alpha-pinene synthase, chloroplastic Proteins 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241001505332 Polyomavirus sp. Species 0.000 description 1
- 101710091608 Probable diacyglycerol O-acyltransferase tgs2 Proteins 0.000 description 1
- 241000192137 Prochlorococcus marinus Species 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
- 102000012751 Pyruvate Dehydrogenase Complex Human genes 0.000 description 1
- 108010090051 Pyruvate Dehydrogenase Complex Proteins 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 241000316848 Rhodococcus <scale insect> Species 0.000 description 1
- 108091028664 Ribonucleotide Proteins 0.000 description 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
- 241000235070 Saccharomyces Species 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- CWHJIJJSDGEHNS-MYLFLSLOSA-N Senegenin Chemical compound C1[C@H](O)[C@H](O)[C@@](C)(C(O)=O)[C@@H]2CC[C@@]3(C)C(CC[C@]4(CCC(C[C@H]44)(C)C)C(O)=O)=C4[C@@H](CCl)C[C@@H]3[C@]21C CWHJIJJSDGEHNS-MYLFLSLOSA-N 0.000 description 1
- 102100030413 Spermidine synthase Human genes 0.000 description 1
- YCFJXOFFQLPCHD-UHFFFAOYSA-N Spinacin Natural products C1NC(C(=O)O)CC2=C1NC=N2 YCFJXOFFQLPCHD-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000122971 Stenotrophomonas Species 0.000 description 1
- 241001468227 Streptomyces avermitilis Species 0.000 description 1
- 241000145545 Streptomyces collinus Species 0.000 description 1
- 241000187398 Streptomyces lividans Species 0.000 description 1
- 241001468239 Streptomyces murinus Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 108700025695 Suppressor Genes Proteins 0.000 description 1
- 241001453296 Synechococcus elongatus Species 0.000 description 1
- 241000135402 Synechococcus elongatus PCC 6301 Species 0.000 description 1
- 241000192589 Synechococcus elongatus PCC 7942 Species 0.000 description 1
- 241001313699 Thermosynechococcus elongatus Species 0.000 description 1
- 102100028601 Transaldolase Human genes 0.000 description 1
- 108020004530 Transaldolase Proteins 0.000 description 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
- 241000378866 Trichoderma koningii Species 0.000 description 1
- 241000223262 Trichoderma longibrachiatum Species 0.000 description 1
- 241000078013 Trichormus variabilis Species 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- DRQXUCVJDCRJDB-UHFFFAOYSA-N Turanose Natural products OC1C(CO)OC(O)(CO)C1OC1C(O)C(O)C(O)C(CO)O1 DRQXUCVJDCRJDB-UHFFFAOYSA-N 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 241000235013 Yarrowia Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- OBOXTJCIIVUZEN-UHFFFAOYSA-N [C].[O] Chemical compound [C].[O] OBOXTJCIIVUZEN-UHFFFAOYSA-N 0.000 description 1
- 150000008065 acid anhydrides Chemical class 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000001261 affinity purification Methods 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 108010004469 allophycocyanin Proteins 0.000 description 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-PQMKYFCFSA-N alpha-D-mannose Chemical compound OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-PQMKYFCFSA-N 0.000 description 1
- SRBFZHDQGSBBOR-LECHCGJUSA-N alpha-D-xylose Chemical compound O[C@@H]1CO[C@H](O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-LECHCGJUSA-N 0.000 description 1
- SRBFZHDQGSBBOR-QMKXCQHVSA-N alpha-L-arabinopyranose Chemical compound O[C@H]1CO[C@@H](O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-QMKXCQHVSA-N 0.000 description 1
- AGBQKNBQESQNJD-UHFFFAOYSA-N alpha-Lipoic acid Natural products OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000006229 amino acid addition Effects 0.000 description 1
- 229960003311 ampicillin trihydrate Drugs 0.000 description 1
- 229940053200 antiepileptics fatty acid derivative Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 108010051210 beta-Fructofuranosidase Proteins 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 230000000035 biogenic effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 150000005693 branched-chain amino acids Chemical class 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 238000004523 catalytic cracking Methods 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000007233 catalytic pyrolysis Methods 0.000 description 1
- 238000001833 catalytic reforming Methods 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 230000004700 cellular uptake Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 210000000166 cellulosome Anatomy 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- HRYZWHHZPQKTII-UHFFFAOYSA-N chloroethane Chemical compound CCCl HRYZWHHZPQKTII-UHFFFAOYSA-N 0.000 description 1
- 230000002759 chromosomal effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000012411 cloning technique Methods 0.000 description 1
- 239000013599 cloning vector Substances 0.000 description 1
- 101150109763 coaW gene Proteins 0.000 description 1
- 101150051152 coaX gene Proteins 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- QRSKGVRHSLILFG-TYHXJLICSA-N cyclohexane-1-carbonyl-CoA Chemical compound O=C([C@H](O)C(C)(COP(O)(=O)OP(O)(=O)OC[C@@H]1[C@H]([C@@H](O)[C@@H](O1)N1C2=NC=NC(N)=C2N=C1)OP(O)(O)=O)C)NCCC(=O)NCCSC(=O)C1CCCCC1 QRSKGVRHSLILFG-TYHXJLICSA-N 0.000 description 1
- 125000006639 cyclohexyl carbonyl group Chemical group 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000005547 deoxyribonucleotide Substances 0.000 description 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- MXHRCPNRJAMMIM-UHFFFAOYSA-N desoxyuridine Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-UHFFFAOYSA-N 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 108010003123 dihydrolipoamide acyltransferase Proteins 0.000 description 1
- WASQWSOJHCZDFK-UHFFFAOYSA-N diketene Chemical compound C=C1CC(=O)O1 WASQWSOJHCZDFK-UHFFFAOYSA-N 0.000 description 1
- NAGJZTKCGNOGPW-UHFFFAOYSA-K dioxido-sulfanylidene-sulfido-$l^{5}-phosphane Chemical compound [O-]P([O-])([S-])=S NAGJZTKCGNOGPW-UHFFFAOYSA-K 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 150000002081 enamines Chemical class 0.000 description 1
- 238000000407 epitaxy Methods 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 102000013165 exonuclease Human genes 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 101150104461 fabM gene Proteins 0.000 description 1
- 101150061398 fabR gene Proteins 0.000 description 1
- 101150016526 fadE gene Proteins 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000013861 fat-free Nutrition 0.000 description 1
- 235000019387 fatty acid methyl ester Nutrition 0.000 description 1
- 125000001924 fatty-acyl group Chemical group 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000008713 feedback mechanism Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000037433 frameshift Effects 0.000 description 1
- 239000000295 fuel oil Substances 0.000 description 1
- 239000003747 fuel oil additive Substances 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 238000000769 gas chromatography-flame ionisation detection Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 101150095733 gpsA gene Proteins 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 101150116274 gspA gene Proteins 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000000703 high-speed centrifugation Methods 0.000 description 1
- 238000002744 homologous recombination Methods 0.000 description 1
- 230000006801 homologous recombination Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 102000057593 human F8 Human genes 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- ZHUXMBYIONRQQX-UHFFFAOYSA-N hydroxidodioxidocarbon(.) Chemical compound [O]C(O)=O ZHUXMBYIONRQQX-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- YQYJSBFKSSDGFO-FWAVGLHBSA-N hygromycin A Chemical compound O[C@H]1[C@H](O)[C@H](C(=O)C)O[C@@H]1Oc1ccc(\C=C(/C)C(=O)N[C@@H]2[C@@H]([C@H]3OCO[C@H]3[C@@H](O)[C@@H]2O)O)cc1O YQYJSBFKSSDGFO-FWAVGLHBSA-N 0.000 description 1
- 150000002466 imines Chemical class 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229940097275 indigo Drugs 0.000 description 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004434 industrial solvent Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 235000011073 invertase Nutrition 0.000 description 1
- AEWHYWSPVRZHCT-NDZSKPAWSA-N isobutyryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C(C)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 AEWHYWSPVRZHCT-NDZSKPAWSA-N 0.000 description 1
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 1
- 239000010699 lard oil Substances 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 235000019136 lipoic acid Nutrition 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 108010062385 long-chain-alcohol O-fatty-acyltransferase Proteins 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 239000012092 media component Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000010813 municipal solid waste Substances 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- RZJRJXONCZWCBN-UHFFFAOYSA-N octadecane Chemical compound CCCCCCCCCCCCCCCCCC RZJRJXONCZWCBN-UHFFFAOYSA-N 0.000 description 1
- 229940038384 octadecane Drugs 0.000 description 1
- 101150021317 odhA gene Proteins 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 238000005895 oxidative decarboxylation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 150000002924 oxiranes Chemical class 0.000 description 1
- 229940097411 palm acid Drugs 0.000 description 1
- 229940014662 pantothenate Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 229940049547 paraxin Drugs 0.000 description 1
- 150000004965 peroxy acids Chemical class 0.000 description 1
- 101150031287 petH gene Proteins 0.000 description 1
- 239000003209 petroleum derivative Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 150000008300 phosphoramidites Chemical class 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 230000000243 photosynthetic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000006337 proteolytic cleavage Effects 0.000 description 1
- 101150108780 pta gene Proteins 0.000 description 1
- 238000000197 pyrolysis Methods 0.000 description 1
- 229940076788 pyruvate Drugs 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 230000018612 quorum sensing Effects 0.000 description 1
- 238000002708 random mutagenesis Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 229940047431 recombinate Drugs 0.000 description 1
- 239000012925 reference material Substances 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 230000008521 reorganization Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002336 ribonucleotide Substances 0.000 description 1
- 125000002652 ribonucleotide group Chemical group 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- MPWBFDHTXSODPB-SXQYHYLKSA-N s-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] cycloheptanecarbothioate Chemical compound O=C([C@H](O)C(C)(COP(O)(=O)OP(O)(=O)OC[C@@H]1[C@H]([C@@H](O)[C@@H](O1)N1C2=NC=NC(N)=C2N=C1)OP(O)(O)=O)C)NCCC(=O)NCCSC(=O)C1CCCCCC1 MPWBFDHTXSODPB-SXQYHYLKSA-N 0.000 description 1
- 235000012045 salad Nutrition 0.000 description 1
- 238000011218 seed culture Methods 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 230000008771 sex reversal Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000002553 single reaction monitoring Methods 0.000 description 1
- 238000013426 sirius red morphometry Methods 0.000 description 1
- 101150009574 sll0208 gene Proteins 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- RPLOPBHEZLFENN-HTMVYDOJSA-M sodium;4-[(2r,3r)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoate Chemical compound [Na+].[O-]C(=O)CCC(=O)OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 RPLOPBHEZLFENN-HTMVYDOJSA-M 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- UNFWWIHTNXNPBV-WXKVUWSESA-N spectinomycin Chemical compound O([C@@H]1[C@@H](NC)[C@@H](O)[C@H]([C@@H]([C@H]1O1)O)NC)[C@]2(O)[C@H]1O[C@H](C)CC2=O UNFWWIHTNXNPBV-WXKVUWSESA-N 0.000 description 1
- 229960000268 spectinomycin Drugs 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000003153 stable transfection Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000004230 steam cracking Methods 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 101150111745 sucA gene Proteins 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 229940014800 succinic anhydride Drugs 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- 239000009871 tenuigenin Substances 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 150000003544 thiamines Chemical class 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000011637 translesion synthesis Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- RULSWEULPANCDV-PIXUTMIVSA-N turanose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](C(=O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RULSWEULPANCDV-PIXUTMIVSA-N 0.000 description 1
- 150000003668 tyrosines Chemical group 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000008096 xylene Chemical class 0.000 description 1
- 229960003487 xylose Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10L—FUELS NOT OTHERWISE PROVIDED FOR; NATURAL GAS; SYNTHETIC NATURAL GAS OBTAINED BY PROCESSES NOT COVERED BY SUBCLASSES C10G, C10K; LIQUEFIED PETROLEUM GAS; ADDING MATERIALS TO FUELS OR FIRES TO REDUCE SMOKE OR UNDESIRABLE DEPOSITS OR TO FACILITATE SOOT REMOVAL; FIRELIGHTERS
- C10L1/00—Liquid carbonaceous fuels
- C10L1/02—Liquid carbonaceous fuels essentially based on components consisting of carbon, hydrogen, and oxygen only
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
- C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/649—Biodiesel, i.e. fatty acid alkyl esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/0108—Long-chain acyl-[acyl-carrier-protein] reductase (1.2.1.80)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/99—Other Carbon-Carbon Lyases (1.4.99)
- C12Y401/99005—Octadecanal decarbonylase (4.1.99.5)
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10L—FUELS NOT OTHERWISE PROVIDED FOR; NATURAL GAS; SYNTHETIC NATURAL GAS OBTAINED BY PROCESSES NOT COVERED BY SUBCLASSES C10G, C10K; LIQUEFIED PETROLEUM GAS; ADDING MATERIALS TO FUELS OR FIRES TO REDUCE SMOKE OR UNDESIRABLE DEPOSITS OR TO FACILITATE SOOT REMOVAL; FIRELIGHTERS
- C10L2200/00—Components of fuel compositions
- C10L2200/04—Organic compounds
- C10L2200/0461—Fractions defined by their origin
- C10L2200/0469—Renewables or materials of biological origin
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10L—FUELS NOT OTHERWISE PROVIDED FOR; NATURAL GAS; SYNTHETIC NATURAL GAS OBTAINED BY PROCESSES NOT COVERED BY SUBCLASSES C10G, C10K; LIQUEFIED PETROLEUM GAS; ADDING MATERIALS TO FUELS OR FIRES TO REDUCE SMOKE OR UNDESIRABLE DEPOSITS OR TO FACILITATE SOOT REMOVAL; FIRELIGHTERS
- C10L2290/00—Fuel preparation or upgrading, processes or apparatus therefore, comprising specific process steps or apparatus units
- C10L2290/26—Composting, fermenting or anaerobic digestion fuel components or materials from which fuels are prepared
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02T—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO TRANSPORTATION
- Y02T50/00—Aeronautics or air transport
- Y02T50/60—Efficient propulsion technologies, e.g. for aircraft
- Y02T50/678—Aviation using fuels of non-fossil origin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Description
Claims (23)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510870936.4A CN105483068A (zh) | 2008-05-16 | 2009-05-18 | 产生碳氢化合物的方法和组合物 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5395508P | 2008-05-16 | 2008-05-16 | |
US61/053,955 | 2008-05-16 | ||
PCT/US2009/044409 WO2009140696A2 (en) | 2008-05-16 | 2009-05-18 | Methods and compositions for producing hydrocarbons |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510870936.4A Division CN105483068A (zh) | 2008-05-16 | 2009-05-18 | 产生碳氢化合物的方法和组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102027109A CN102027109A (zh) | 2011-04-20 |
CN102027109B true CN102027109B (zh) | 2016-01-06 |
Family
ID=41056736
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510575363.2A Active CN105112454B (zh) | 2008-05-16 | 2009-05-18 | 产生碳氢化合物的方法和组合物 |
CN200980117664.3A Active CN102027109B (zh) | 2008-05-16 | 2009-05-18 | 产生碳氢化合物的方法和组合物 |
CN201510578739.5A Active CN105112455B (zh) | 2008-05-16 | 2009-05-18 | 产生碳氢化合物的方法和组合物 |
CN201510870936.4A Pending CN105483068A (zh) | 2008-05-16 | 2009-05-18 | 产生碳氢化合物的方法和组合物 |
CN2009801176639A Pending CN102027108A (zh) | 2008-05-16 | 2009-05-18 | 产生碳氢化合物的方法和组合物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510575363.2A Active CN105112454B (zh) | 2008-05-16 | 2009-05-18 | 产生碳氢化合物的方法和组合物 |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510578739.5A Active CN105112455B (zh) | 2008-05-16 | 2009-05-18 | 产生碳氢化合物的方法和组合物 |
CN201510870936.4A Pending CN105483068A (zh) | 2008-05-16 | 2009-05-18 | 产生碳氢化合物的方法和组合物 |
CN2009801176639A Pending CN102027108A (zh) | 2008-05-16 | 2009-05-18 | 产生碳氢化合物的方法和组合物 |
Country Status (11)
Country | Link |
---|---|
US (11) | US8323924B2 (zh) |
EP (5) | EP3483265B1 (zh) |
JP (2) | JP2011522525A (zh) |
KR (2) | KR101739511B1 (zh) |
CN (5) | CN105112454B (zh) |
AU (2) | AU2009246082A1 (zh) |
BR (2) | BRPI0912690A2 (zh) |
CA (3) | CA2722441C (zh) |
ES (4) | ES2536194T3 (zh) |
MX (3) | MX343063B (zh) |
WO (2) | WO2009140696A2 (zh) |
Families Citing this family (113)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
US20100242345A1 (en) | 2006-05-19 | 2010-09-30 | LS9, Inc | Production of fatty acids & derivatives thereof |
ES2703775T3 (es) | 2008-03-05 | 2019-03-12 | Genomatica Inc | Organismos productores de alcoholes primarios |
MX343063B (es) | 2008-05-16 | 2016-10-21 | Reg Life Sciences Llc | Metodos y composiciones para producir hidrocarburos. |
US20110146142A1 (en) * | 2008-08-18 | 2011-06-23 | Ls9, Inc. | Systems and methods for production of mixed fatty esters |
ES2692918T3 (es) | 2008-10-07 | 2018-12-05 | REG Life Sciences, LLC | Métodos y composiciones para producir aldehídos grasos |
CA3146669A1 (en) | 2008-10-28 | 2010-06-03 | Genomatica, Inc. | Methods for producing a fatty alcohol in a host cell |
US20150017694A1 (en) * | 2008-11-06 | 2015-01-15 | Kiverdi, Inc. | Engineered CO2-Fixing Chemotrophic Microorganisms Producing Carbon-Based Products and Methods of Using the Same |
US9957534B2 (en) | 2008-11-06 | 2018-05-01 | Kiverdi, Inc. | Engineered CO2-fixing chemotrophic microorganisms producing carbon-based products and methods of using the same |
WO2013082309A1 (en) * | 2011-11-29 | 2013-06-06 | Kiverdi, Inc. | Process for growing natural or engineered high lipid accumulating strain on crude glycerol and/or other sources of waste carbon for the production of oils, fuels, oleochemicals, and other valuable organic compounds |
US9879290B2 (en) * | 2008-11-06 | 2018-01-30 | Kiverdi, Inc. | Industrial fatty acid engineering general system for modifying fatty acids |
ES2730713T3 (es) | 2008-12-23 | 2019-11-12 | Reg Life Sciences Llc | Métodos y composiciones relacionados con enzimas tioesterasas |
EP2417246A4 (en) * | 2009-04-10 | 2015-11-04 | Reg Life Sciences Llc | PRODUCTION OF FATTY ACID DERIVATIVES |
CN111808892A (zh) | 2009-04-27 | 2020-10-23 | 基因组股份公司 | 脂肪酸酯的产生 |
BRPI1013277A2 (pt) | 2009-06-30 | 2016-10-11 | Codexis Inc | produção de alcoóis graxos a partir de células hospedeiras recombinantes e seus usos |
AU2012200694B2 (en) * | 2009-07-09 | 2012-11-01 | Joule Unlimited Technologies, Inc. | Methods and compositions for the recombinant biosynthesis of N-alkanes |
US7955820B1 (en) | 2009-07-09 | 2011-06-07 | Joule Unlimited, Inc. | Methods and compositions for the recombinant biosynthesis of n-alkanes |
AU2011204785B2 (en) * | 2009-07-09 | 2013-08-15 | Joule Unlimited Technologies, Inc. | Methods and compositions for the recombinant biosynthesis of N-alkanes |
US7794969B1 (en) * | 2009-07-09 | 2010-09-14 | Joule Unlimited, Inc. | Methods and compositions for the recombinant biosynthesis of n-alkanes |
WO2011038132A1 (en) * | 2009-09-25 | 2011-03-31 | Ls9, Inc. | Production of fatty acid derivatives |
BR112012006801A2 (pt) | 2009-09-27 | 2018-04-10 | Opx Biotechnologies Inc | método para produção de ácido 3-hidroxipropiônico e outros produtos |
WO2011062987A2 (en) * | 2009-11-17 | 2011-05-26 | Ls9, Inc. | Methods and compositions for producing hydrocarbons |
US9217161B2 (en) | 2009-12-04 | 2015-12-22 | Richard Allen Kohn | Process for producing fermentation products and fermentation medium compositions therefor |
US8530221B2 (en) | 2010-01-14 | 2013-09-10 | Ls9, Inc. | Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells |
US8859259B2 (en) | 2010-02-14 | 2014-10-14 | Ls9, Inc. | Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols |
AR084377A1 (es) * | 2010-04-08 | 2013-05-15 | Ls9 Inc | Metodos y composiciones relacionados con enzimas de alcohol graso biosintetico |
CA2802186A1 (en) * | 2010-06-10 | 2011-12-15 | Korea Advanced Institute Of Science And Technology | Microorganism variants having hydrocarbon producing ability and method for producing hydrocarbon using the same |
WO2012006114A2 (en) | 2010-06-28 | 2012-01-12 | Codexis, Inc. | Fatty alcohol forming acyl reductases (fars) and methods of use thereof |
WO2012037285A2 (en) * | 2010-09-14 | 2012-03-22 | Joule Unlimited Technologies, Inc. | Methods and compositions for targeting heterologous integral membrane proteins to the cyanobacterial plasma membrane |
US8372610B2 (en) | 2010-09-15 | 2013-02-12 | Ls9, Inc. | Production of odd chain fatty acid derivatives in recombinant microbial cells |
WO2012087963A1 (en) * | 2010-12-20 | 2012-06-28 | Targeted Growth, Inc. | Modified photosynthetic microorganisms for producing lipids |
US20130035513A1 (en) * | 2011-01-26 | 2013-02-07 | Ls9, Inc. | Methods and compositions for enhanced production of fatty aldehydes and fatty alcohols |
RU2013136501A (ru) * | 2011-02-17 | 2015-03-27 | Дзе Проктер Энд Гэмбл Компани | Линейные алкилфенилсульфонаты на основе биологического сырья |
RU2013136500A (ru) | 2011-02-17 | 2015-03-27 | Дзе Проктер Энд Гэмбл Компани | Композиции, содержащие смеси с10-с13-алкилфенилсульфонатов |
WO2012119078A2 (en) | 2011-03-03 | 2012-09-07 | Tersus Pharmaceuticals, LLC | COMPOSITIONS AND METHODS COMPRISING C16:1n7-PALMITOLEATE |
WO2012129537A1 (en) | 2011-03-23 | 2012-09-27 | Joule Unlimited Technologies, Inc. | Photoalkanogens with increased productivity |
WO2012135668A1 (en) | 2011-03-31 | 2012-10-04 | Exxonmobil Research And Engineering Company | Metabolic pathway targeting by transcription factor overexpression |
EP2720997A1 (en) | 2011-06-17 | 2014-04-23 | Invista Technologies S.à.r.l. | Use of hydrolases to increase monomer content in waste stream |
WO2012177943A1 (en) | 2011-06-22 | 2012-12-27 | Genomatica, Inc. | Microorganisms for producing 1,4-butanediol and methods related thereto |
WO2013003744A2 (en) | 2011-06-30 | 2013-01-03 | Invista Techonologies S.A R.L | Bioconversion process for producing nylon-7, nylon-7,7 and polyesters |
DE112011105535B4 (de) | 2011-08-15 | 2018-08-16 | Toyota Jidosha Kabushiki Kaisha | Verfahren zum Herstellen eines Alkans und rekombinanter Mikroorganismus, der in der Lage ist, das Alkan zu synthetisieren |
DE102011110945A1 (de) | 2011-08-15 | 2013-02-21 | Evonik Degussa Gmbh | Biotechnologisches Syntheseverfahren von organischen Verbindungen mit alkIL-Genprodukt |
DE102011110946A1 (de) | 2011-08-15 | 2016-01-21 | Evonik Degussa Gmbh | Biotechnologisches Syntheseverfahren von omegafunktionalisierten Carbonsäuren und Carbonsäure-Estern aus einfachen Kohlenstoffquellen |
WO2013032891A1 (en) * | 2011-08-26 | 2013-03-07 | Brookhaven Science Associates, Llc | Compositions and methods for the relief of inhibition of aldehyde decarbonylase |
CN102952818B (zh) | 2011-08-26 | 2016-03-02 | 中国科学院青岛生物能源与过程研究所 | 用于在蓝细菌中提高脂肪醇产量的构建体和方法 |
BR112014007115A2 (pt) | 2011-09-27 | 2017-04-25 | Exxonmobil Res & Eng Co | éster sintases de cera acil-acp |
US9556458B2 (en) | 2011-10-27 | 2017-01-31 | The Regents Of The University Of California | Bacterial production of methyl ketones |
US9102960B2 (en) | 2011-12-16 | 2015-08-11 | Invista North America S.á.r.l. | Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage |
US9102958B2 (en) | 2011-12-16 | 2015-08-11 | Invista North America S.á.r.l. | Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage |
CN103194418B (zh) * | 2012-01-04 | 2014-09-03 | 武汉臻智生物科技有限公司 | 一种制备脂肪烷烃及其中间体烯烃的方法 |
WO2013124439A2 (en) * | 2012-02-24 | 2013-08-29 | Shell Internationale Research Maatschappij B.V. | Method for preparing a hydrocarbon |
EP2814972B1 (en) | 2012-02-24 | 2020-04-22 | ExxonMobil Research and Engineering Company | Enhanced production of fatty acids and fatty acid derivatives by recombinant microorganisms |
US9096834B2 (en) | 2012-02-24 | 2015-08-04 | Exxonmobil Research And Engineering Company | Recombinant microorganisms comprising thioesterase and lysophosphatidic acid acyltransferase genes for fatty acid production |
JP5867586B2 (ja) * | 2012-02-27 | 2016-02-24 | トヨタ自動車株式会社 | 炭化水素合成酵素遺伝子及びその利用 |
BR122019026127B1 (pt) | 2012-04-02 | 2021-12-21 | Genomatica, Inc. | Célula hospedeira recombinante e cultura celular |
US9163267B2 (en) | 2012-04-11 | 2015-10-20 | REG Life Sciences, LLC | Metathesis transformations of microbially-produced fatty acids and fatty acid derivatives |
US9181568B2 (en) | 2012-04-23 | 2015-11-10 | Exxonmobil Research And Engineering Company | Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases |
DE102012207921A1 (de) | 2012-05-11 | 2013-11-14 | Evonik Industries Ag | Mehrstufiges Syntheseverfahren mit Synthesegas |
US8946491B2 (en) | 2012-05-17 | 2015-02-03 | Shell Oil Company | Process for producing volatile organic compounds from biomass material |
AU2013262764B2 (en) | 2012-05-17 | 2015-08-20 | Shell Internationale Research Maatschappij B.V. | Methods and systems for processing biomass material |
IN2015DN00919A (zh) * | 2012-07-13 | 2015-06-12 | Calysta Inc | |
KR20150040359A (ko) | 2012-08-10 | 2015-04-14 | 오피엑스 바이오테크놀로지스, 인크. | 지방산 및 지방산 유도된 산물의 생산을 위한 미생물 및 방법 |
KR20150082251A (ko) | 2012-11-09 | 2015-07-15 | 칼리스타, 인코포레이티드 | 지방산 유도체의 생물학적 생성을 위한 조성물 및 방법 |
US20160002681A1 (en) | 2012-12-12 | 2016-01-07 | REG Life Sciences, LLC | Acp-mediated production of fatty acid derivatives |
BR112015013413A2 (pt) | 2012-12-14 | 2017-11-14 | Invista Tech Sarl | método para biosintetizar um produto e hospedeiro recombinante |
WO2014105788A2 (en) | 2012-12-31 | 2014-07-03 | Invista North America S.A.R.L. | Methods of producing 7-carbon chemicals via carbon chain elongation associated with cyclohexane carboxylate synthesis |
EP2938735A2 (en) | 2012-12-31 | 2015-11-04 | Invista Technologies S.A R.L. | Methods of producing 7-carbon chemicals via pyruvate and succinate semialdehyde aldol condensation |
EP2938732A1 (en) | 2012-12-31 | 2015-11-04 | Invista Technologies S.à.r.l. | Methods of producing 7-carbon chemicals from long chain fatty acids via oxidative cleavage |
US9617572B2 (en) | 2012-12-31 | 2017-04-11 | Invista North America S.A.R.L. | Methods of producing 7-carbon chemicals via aromatic compounds |
EP2938736A2 (en) | 2012-12-31 | 2015-11-04 | Invista Technologies S.A R.L. | Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme b synthesis |
US9580733B2 (en) | 2012-12-31 | 2017-02-28 | Invista North America S.A.R.L. | Methods of producing 6-carbon chemicals via methyl-ester shielded carbon chain elongation |
US10196657B2 (en) | 2012-12-31 | 2019-02-05 | Invista North America S.A.R.L. | Methods of producing 7-carbon chemicals via methyl-ester shielded carbon chain elongation |
KR102265148B1 (ko) | 2013-01-16 | 2021-06-15 | 게노마티카 인코포레이티드 | 개선된 특성들을 갖는 아실-acp 레덕타아제 |
US9034629B2 (en) | 2013-01-25 | 2015-05-19 | Joule Unlimited Technologies, Inc. | Recombinant synthesis of medium chain-length alkanes |
EP2964598B1 (en) * | 2013-03-07 | 2020-08-26 | Genomatica, Inc. | Downstream processing of fatty alcohol compositions produced by recombinant host cells |
US9267158B2 (en) | 2013-03-14 | 2016-02-23 | Intrexon Corporation | Biological production of multi-carbon compounds from methane |
WO2014146026A1 (en) | 2013-03-15 | 2014-09-18 | Opx Biotechnologies, Inc. | Bioproduction of chemicals |
CA2915229A1 (en) | 2013-06-14 | 2014-12-18 | REG Life Sciences, LLC | Methods of producing omega-hydroxylated fatty acid derivatives |
EP3022310B1 (en) | 2013-07-19 | 2019-10-16 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
AU2014308977B2 (en) | 2013-08-19 | 2017-03-02 | Genomatica, Inc. | Production of partially refined waste glycerol |
US9469586B2 (en) | 2013-08-19 | 2016-10-18 | REG Life Sciences, LLC | Production of partially refined waste glycerol |
CN113493759A (zh) | 2013-09-13 | 2021-10-12 | 基因组股份公司 | 改进的乙酰-coa羧化酶变体 |
ES2932529T3 (es) | 2013-12-05 | 2023-01-20 | Genomatica Inc | Producción microbiana de aminas grasas |
WO2015157719A1 (en) | 2014-04-10 | 2015-10-15 | REG Life Sciences, LLC | Semisynthetic routes to organic compounds |
CN106574283A (zh) | 2014-05-15 | 2017-04-19 | 英威达技术有限责任公司 | 使用2,6‑二氨基庚二酸作为2‑氨基庚二酸的前体生产6‑碳化学品的方法 |
JP6034332B2 (ja) | 2014-05-30 | 2016-11-30 | トヨタ自動車株式会社 | 組換え微生物及び当該組換え微生物を用いた物質製造方法 |
JP6189793B2 (ja) | 2014-05-30 | 2017-08-30 | トヨタ自動車株式会社 | 組換え微生物及び当該組換え微生物を用いた物質製造方法 |
WO2015191434A2 (en) | 2014-06-09 | 2015-12-17 | Stepan Company | Detergents for cold-water cleaning |
US9988654B2 (en) | 2014-06-16 | 2018-06-05 | Invista North America S.A.R.L. | Methods, reagents and cells for biosynthesizing compounds |
EP3155108A1 (en) | 2014-06-16 | 2017-04-19 | Invista Technologies S.à.r.l. | Methods, reagents and cells for biosynthesizing compounds |
WO2015195710A1 (en) | 2014-06-16 | 2015-12-23 | Invista Technlogies S.A.R.L. | Process for producing glutarate and glutaric acid methyl ester |
MX2016016565A (es) | 2014-06-16 | 2017-04-25 | Reg Life Sciences Llc | Polipeptidos de fusion relacionados con omega-hidroxilasa con propiedades mejoradas. |
BR112016029375A2 (pt) | 2014-06-16 | 2017-10-17 | Invista Tech Sarl | métodos, reagentes e células para biossintetizar compostos |
ES2700578T3 (es) | 2014-07-18 | 2019-02-18 | Reg Life Sciences Llc | Producción microbiana de 1,3-dioles |
EP2993228B1 (en) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Production of fatty acid esters |
ES2864102T3 (es) | 2015-11-18 | 2021-10-13 | Provivi Inc | Microorganismos para la producción de feromonas de insectos y compuestos relacionados |
WO2017101987A1 (en) | 2015-12-15 | 2017-06-22 | REG Life Sciences, LLC | Omega-hydroxylase-related fusion polypeptide variants with improved properties |
EP3464311A4 (en) | 2016-06-06 | 2020-03-18 | Provivi, Inc. | HALF-BIOSYNTHETIC PRODUCTION OF FATTY ALCOHOLS AND FATTY ALDEHYDES |
JP7058659B2 (ja) | 2016-09-14 | 2022-04-22 | ジェノマティカ, インコーポレイテッド | 1,3-脂肪ジオール化合物およびそれらの誘導体 |
JP6607204B2 (ja) * | 2017-01-17 | 2019-11-20 | トヨタ自動車株式会社 | アルカン合成能を有する組換え微生物及びアルカンの製造方法 |
US11345938B2 (en) | 2017-02-02 | 2022-05-31 | Cargill, Incorporated | Genetically modified cells that produce C6-C10 fatty acid derivatives |
JP2018143192A (ja) * | 2017-03-08 | 2018-09-20 | 花王株式会社 | 脂肪族アルコールの生産方法 |
CA3058950A1 (en) | 2017-04-03 | 2018-10-11 | Genomatica, Inc. | Thioesterase variants having improved activity for the production of medium-chain fatty acid derivatives |
JP7216018B2 (ja) | 2017-05-17 | 2023-01-31 | プロヴィヴィ インコーポレイテッド | 昆虫フェロモンの生成のための微生物及び関連する化合物 |
CN109207415B (zh) | 2017-07-07 | 2022-09-16 | 苏州华赛生物工程技术有限公司 | 一种生产胞二磷胆碱的重组微生物及生产胞二磷胆碱的方法 |
US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
CN112673016A (zh) | 2018-08-31 | 2021-04-16 | 基因组股份公司 | 用于改善的木糖利用或改善的葡萄糖和木糖共利用的xylr突变体 |
JP2020080705A (ja) * | 2018-11-22 | 2020-06-04 | トヨタ自動車株式会社 | 変異型デカルボニラーゼ遺伝子、当該変異型デカルボニラーゼ遺伝子を有する組換え微生物及びアルカンの製造方法 |
CN109486835B (zh) * | 2018-12-05 | 2022-02-11 | 中国科学院合肥物质科学研究院 | 一种源于蓝藻的产烷烃关键基因突变子及其应用 |
JP7131416B2 (ja) | 2019-02-01 | 2022-09-06 | トヨタ自動車株式会社 | 変異型デカルボニラーゼ遺伝子、当該変異型デカルボニラーゼ遺伝子を有する組換え微生物及びアルカンの製造方法 |
JP2020141560A (ja) | 2019-03-04 | 2020-09-10 | トヨタ自動車株式会社 | 新規アルデヒド合成酵素遺伝子、当該遺伝子を有する組換え微生物及びこれを用いたアルカンの製造方法 |
WO2023178193A1 (en) | 2022-03-16 | 2023-09-21 | Genomatica, Inc. | Acyl-acp thioesterase variants and uses thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007136762A2 (en) * | 2006-05-19 | 2007-11-29 | Ls9, Inc. | Production of fatty acids and derivatives thereof |
Family Cites Families (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3149170A1 (de) | 1980-12-15 | 1982-07-29 | Institut Français du Pétrole, 92502 Rueil-Malmaison, Hauts-de-Seine | Brennbare komposition, welche gasoel, methanol und einen fettsaeureester enthalten und als dieseltreibstoff brauchbar sind |
US5424202A (en) | 1988-08-31 | 1995-06-13 | The University Of Florida | Ethanol production by recombinant hosts |
US5482846A (en) | 1988-08-31 | 1996-01-09 | University Of Florida | Ethanol production in Gram-positive microbes |
US5028539A (en) | 1988-08-31 | 1991-07-02 | The University Of Florida | Ethanol production using engineered mutant E. coli |
US5000000A (en) | 1988-08-31 | 1991-03-19 | University Of Florida | Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes |
US7053267B2 (en) | 1990-03-16 | 2006-05-30 | Calgene Llc | Plant seed oils |
AU7791991A (en) | 1990-04-24 | 1991-11-11 | Stratagene | Methods for phenotype creation from multiple gene populations |
EP0563191B2 (en) | 1990-12-20 | 2000-01-19 | E.I. Du Pont De Nemours And Company | Nucleotide sequences of soybean acyl-acp thioesterase genes |
WO1992014816A1 (en) * | 1991-02-22 | 1992-09-03 | Calgene, Inc. | Seed plant fatty acyl reductase proteins and genes |
EP0700376A4 (en) | 1993-05-25 | 1996-05-22 | Auckland Uniservices Ltd | NITROBENZILE MUSTARD QUARTERARY SALTS AND THEIR USE AS CYTOTOXIC AGENTS SELECTIVELY ACTING AGAINST HYPOXIA |
US6583266B1 (en) | 1993-08-19 | 2003-06-24 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to mycobacterium tuberculosis and leprae for diagnostics and therapeutics |
US5807893A (en) | 1993-11-18 | 1998-09-15 | Voelker; Toni Alois | Plant thioesterases and use for modification of fatty acid composition in plant seed oils |
US5602030A (en) | 1994-03-28 | 1997-02-11 | University Of Florida Research Foundation | Recombinant glucose uptake system |
US6428767B1 (en) | 1995-05-12 | 2002-08-06 | E. I. Du Pont De Nemours And Company | Method for identifying the source of carbon in 1,3-propanediol |
US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
US5939250A (en) | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
US20080178519A1 (en) | 1996-11-18 | 2008-07-31 | Bp Oil International Limited | Fuel composition |
JP4126102B2 (ja) | 1997-06-05 | 2008-07-30 | カルジーン エル エル シー | 脂肪アシル−CoA:脂肪アルコールアシルトランスフェラーゼ |
RU2212447C2 (ru) | 2000-04-26 | 2003-09-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Штамм escherichia coli - продуцент аминокислоты (варианты) и способ получения аминокислот (варианты) |
ATE461273T1 (de) * | 2000-11-17 | 2010-04-15 | Metabolix Inc | Herstellung von polyhydroxyalkanoaten mittlerer kettenlänge aus fettsäure-biosynthesewegen |
WO2002074903A2 (en) | 2001-02-22 | 2002-09-26 | Institut Pasteur | Comparative mycobacterial geneomics as a tool for identifying targets for the diagnosis, prophylaxis or treatment of mycobacterioses |
US6686133B2 (en) | 2001-03-29 | 2004-02-03 | Agfa-Gevaert | Photothermographic materials processable at lower temperatures and recording processes therefor |
US7314974B2 (en) | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
AR038719A1 (es) | 2002-03-01 | 2005-01-26 | Monsanto Technology Llc | Secuencia de adn de sintetasas bacterianas de esteres cerosos, proteinas y usos de las mismas |
US7056714B2 (en) | 2003-03-11 | 2006-06-06 | University Of Iowa Research Foundation, Inc. | Carboxylic acid reductase polypeptide, nucleotide sequence encoding same and methods of use |
US7070958B2 (en) | 2003-04-18 | 2006-07-04 | Thrombolytic Science, Inc. | Methods of making pro-urokinase mutants |
US7608700B2 (en) | 2004-03-08 | 2009-10-27 | North Carolina State University | Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor |
WO2005087455A1 (en) | 2004-03-18 | 2005-09-22 | Sca Hygiene Products Ab | Method and device for producing a multi-ply web of flexible material, such as paper and nonwoven, and multi-ply material produced by the method |
WO2006085899A2 (en) | 2004-05-21 | 2006-08-17 | The Regents Of The University Of California | Method for enhancing production of isoprenoid compounds |
US7756833B2 (en) * | 2004-09-22 | 2010-07-13 | Microsoft Corporation | Method and system for synthetic backup and restore |
WO2006130529A1 (en) | 2005-05-31 | 2006-12-07 | Pierce Biotechnology, Inc. | Extraction of cellular components with fatty acid derivatives |
FR2888034B1 (fr) | 2005-06-29 | 2010-10-08 | Philippe Magnier | Dispositif de prevention contre l'explosion d'un transformateur electrique |
MX2008002278A (es) | 2005-08-15 | 2008-04-09 | Arizona Chem | Acido graso de aceite de bogol bajo en azufre. |
US7482480B2 (en) * | 2005-10-10 | 2009-01-27 | Council Of Scientific & Industrial Research | Process for the preparation of hydrocarbon fuel |
PL1966357T3 (pl) * | 2005-12-12 | 2019-10-31 | Neste Oyj | Olej bazowy |
US7998339B2 (en) * | 2005-12-12 | 2011-08-16 | Neste Oil Oyj | Process for producing a hydrocarbon component |
US8535916B2 (en) | 2006-02-13 | 2013-09-17 | Ls9, Inc. | Modified microorganisms and uses therefor |
ITTO20060239A1 (it) | 2006-03-30 | 2007-09-30 | Rotthapharm S P A | Formulazione per somministrazione orale con effetti salutistici sull'apparato cardiovascolare |
US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
CN101490241A (zh) * | 2006-05-19 | 2009-07-22 | Ls9公司 | 脂肪酸及其衍生物的制备 |
US20100242345A1 (en) | 2006-05-19 | 2010-09-30 | LS9, Inc | Production of fatty acids & derivatives thereof |
US7491854B2 (en) | 2006-05-31 | 2009-02-17 | Archer-Daniels-Midland Company | Enzymatic method of making aldehydes from fatty acids |
DE102006054324A1 (de) | 2006-11-17 | 2008-05-21 | Robert Bosch Gmbh | Verfahren zur bildbasierten Vermessung |
US8110093B2 (en) | 2007-03-14 | 2012-02-07 | Ls9, Inc. | Process for producing low molecular weight hydrocarbons from renewable resources |
AU2008230735A1 (en) * | 2007-03-28 | 2008-10-02 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
WO2008151149A2 (en) | 2007-06-01 | 2008-12-11 | Solazyme, Inc. | Production of oil in microorganisms |
US7897369B2 (en) | 2007-08-27 | 2011-03-01 | Regents Of The University Of Minnesota | Isoprenoid wax ester synthases, isoprenoid acyl CoA-synthetases, and uses thereof |
WO2009042950A1 (en) | 2007-09-27 | 2009-04-02 | Ls9, Inc. | Reduction of the toxic effect of impurities from raw materials by extractive fermentation |
TWI351779B (en) | 2007-12-03 | 2011-11-01 | Advance Smart Ind Ltd | Apparatus and method for correcting residual capac |
WO2009085278A1 (en) | 2007-12-21 | 2009-07-09 | Ls9, Inc. | Methods and compositions for producing olefins |
ES2703775T3 (es) | 2008-03-05 | 2019-03-12 | Genomatica Inc | Organismos productores de alcoholes primarios |
MX343063B (es) | 2008-05-16 | 2016-10-21 | Reg Life Sciences Llc | Metodos y composiciones para producir hidrocarburos. |
US8232924B2 (en) | 2008-05-23 | 2012-07-31 | Alliant Techsystems Inc. | Broadband patch antenna and antenna system |
WO2010022090A1 (en) | 2008-08-18 | 2010-02-25 | Ls9, Inc. | Systems and methods for the production of mixed fatty esters |
ES2692918T3 (es) | 2008-10-07 | 2018-12-05 | REG Life Sciences, LLC | Métodos y composiciones para producir aldehídos grasos |
CA3146669A1 (en) | 2008-10-28 | 2010-06-03 | Genomatica, Inc. | Methods for producing a fatty alcohol in a host cell |
ES2730713T3 (es) | 2008-12-23 | 2019-11-12 | Reg Life Sciences Llc | Métodos y composiciones relacionados con enzimas tioesterasas |
EP2417246A4 (en) | 2009-04-10 | 2015-11-04 | Reg Life Sciences Llc | PRODUCTION OF FATTY ACID DERIVATIVES |
WO2010118410A1 (en) | 2009-04-10 | 2010-10-14 | Ls9, Inc. | Production of fatty acid derivatives |
CN111808892A (zh) | 2009-04-27 | 2020-10-23 | 基因组股份公司 | 脂肪酸酯的产生 |
WO2010127318A2 (en) | 2009-05-01 | 2010-11-04 | The Regents Of The University Of California | Product of fatty acid esters from biomass polymers |
US7794969B1 (en) * | 2009-07-09 | 2010-09-14 | Joule Unlimited, Inc. | Methods and compositions for the recombinant biosynthesis of n-alkanes |
US7955820B1 (en) * | 2009-07-09 | 2011-06-07 | Joule Unlimited, Inc. | Methods and compositions for the recombinant biosynthesis of n-alkanes |
WO2011038132A1 (en) | 2009-09-25 | 2011-03-31 | Ls9, Inc. | Production of fatty acid derivatives |
WO2011062987A2 (en) | 2009-11-17 | 2011-05-26 | Ls9, Inc. | Methods and compositions for producing hydrocarbons |
US8530221B2 (en) | 2010-01-14 | 2013-09-10 | Ls9, Inc. | Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells |
US8859259B2 (en) | 2010-02-14 | 2014-10-14 | Ls9, Inc. | Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols |
US8372610B2 (en) | 2010-09-15 | 2013-02-12 | Ls9, Inc. | Production of odd chain fatty acid derivatives in recombinant microbial cells |
WO2013048661A1 (en) | 2011-09-30 | 2013-04-04 | Codexis, Inc. | Fungal proteases |
-
2009
- 2009-05-18 MX MX2010012197A patent/MX343063B/es active IP Right Grant
- 2009-05-18 CN CN201510575363.2A patent/CN105112454B/zh active Active
- 2009-05-18 EP EP18195170.8A patent/EP3483265B1/en active Active
- 2009-05-18 ES ES09747777.2T patent/ES2536194T3/es active Active
- 2009-05-18 BR BRPI0912690-2A patent/BRPI0912690A2/pt not_active Application Discontinuation
- 2009-05-18 CA CA2722441A patent/CA2722441C/en active Active
- 2009-05-18 CN CN200980117664.3A patent/CN102027109B/zh active Active
- 2009-05-18 KR KR1020107028136A patent/KR101739511B1/ko active IP Right Grant
- 2009-05-18 CA CA2722442A patent/CA2722442C/en active Active
- 2009-05-18 JP JP2011509795A patent/JP2011522525A/ja not_active Ceased
- 2009-05-18 EP EP15153942.6A patent/EP2927315B1/en active Active
- 2009-05-18 CA CA3101888A patent/CA3101888A1/en not_active Abandoned
- 2009-05-18 ES ES09747776.4T patent/ES2667469T3/es active Active
- 2009-05-18 AU AU2009246082A patent/AU2009246082A1/en not_active Abandoned
- 2009-05-18 JP JP2011509796A patent/JP2011520455A/ja not_active Ceased
- 2009-05-18 CN CN201510578739.5A patent/CN105112455B/zh active Active
- 2009-05-18 CN CN201510870936.4A patent/CN105483068A/zh active Pending
- 2009-05-18 MX MX2016013850A patent/MX350285B/es unknown
- 2009-05-18 EP EP15179791.7A patent/EP2998393B1/en active Active
- 2009-05-18 BR BR122020013701-0A patent/BR122020013701B1/pt active IP Right Grant
- 2009-05-18 MX MX2010012192A patent/MX2010012192A/es active IP Right Grant
- 2009-05-18 AU AU2009246083A patent/AU2009246083A1/en not_active Abandoned
- 2009-05-18 ES ES15153942T patent/ES2696773T3/es active Active
- 2009-05-18 KR KR1020107028190A patent/KR101735549B1/ko active IP Right Grant
- 2009-05-18 WO PCT/US2009/044409 patent/WO2009140696A2/en active Application Filing
- 2009-05-18 EP EP09747776.4A patent/EP2288694B1/en active Active
- 2009-05-18 ES ES15179791.7T patent/ES2667718T3/es active Active
- 2009-05-18 EP EP09747777.2A patent/EP2283121B1/en active Active
- 2009-05-18 CN CN2009801176639A patent/CN102027108A/zh active Pending
- 2009-05-18 WO PCT/US2009/044403 patent/WO2009140695A1/en active Application Filing
-
2010
- 2010-02-22 US US12/710,237 patent/US8323924B2/en active Active
- 2010-02-22 US US12/710,238 patent/US8268599B2/en not_active Expired - Fee Related
-
2012
- 2012-07-18 US US13/552,522 patent/US8658404B2/en active Active
- 2012-09-24 US US13/625,107 patent/US8846371B2/en active Active
-
2013
- 2013-10-23 US US14/061,512 patent/US9670512B2/en active Active
-
2014
- 2014-08-28 US US14/472,192 patent/US9481899B2/en active Active
-
2016
- 2016-10-04 US US15/284,727 patent/US10150975B2/en active Active
-
2017
- 2017-05-11 US US15/592,772 patent/US20180080053A1/en not_active Abandoned
-
2018
- 2018-12-04 US US16/209,711 patent/US10563231B2/en not_active Expired - Fee Related
-
2020
- 2020-01-07 US US16/736,405 patent/US11186854B2/en active Active
-
2021
- 2021-10-22 US US17/508,400 patent/US20220259623A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007136762A2 (en) * | 2006-05-19 | 2007-11-29 | Ls9, Inc. | Production of fatty acids and derivatives thereof |
Non-Patent Citations (3)
Title |
---|
Fehler S W等.Biosynthesis of hydrocarbons in Anabaena variabilis. Incorporation of [methyl-14C]- and [methyl-2H3]methionine into 7- and 8-methylheptadecanes.《Biochemistry》.1970,第9卷(第2期),全文. * |
Friedrich Jiittner等.The reducing capacities of cyanobacteria for aldehydes and ketones.《Appl Microbiol Biotechnol》.1986,第25卷全文. * |
Ladygina N等.A review on microbial synthesis of hydrocarbons.《PROCESS BIOCHEMISTRY》.2006,第41卷(第5期),全文. * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102027109B (zh) | 产生碳氢化合物的方法和组合物 | |
CN102232110B (zh) | 产生脂肪醛的方法和组合物 | |
CN102264910B (zh) | 用于产生脂肪醇的方法和组合物 | |
CN102459569B (zh) | 脂肪酸衍生物的产生 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1152342 Country of ref document: HK |
|
ASS | Succession or assignment of patent right |
Owner name: REG LIFE SCIENCES, LLC Free format text: FORMER OWNER: LS9 INC. Effective date: 20141102 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20141102 Address after: American California Applicant after: REG Life Sciences Co.,Ltd. Address before: California, South San Francisco, USA Applicant before: Ls9 Inc. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1152342 Country of ref document: HK |
|
TR01 | Transfer of patent right |
Effective date of registration: 20191210 Address after: California, USA Patentee after: Genomatica, Inc. Address before: California, USA Patentee before: REG Life Sciences Co.,Ltd. |
|
TR01 | Transfer of patent right |