CN101966130A - Silybin nano crystal cosmetics and preparation method thereof - Google Patents
Silybin nano crystal cosmetics and preparation method thereof Download PDFInfo
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- CN101966130A CN101966130A CN 201010295663 CN201010295663A CN101966130A CN 101966130 A CN101966130 A CN 101966130A CN 201010295663 CN201010295663 CN 201010295663 CN 201010295663 A CN201010295663 A CN 201010295663A CN 101966130 A CN101966130 A CN 101966130A
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- oil
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- silybin
- silybin nanostructured
- nanostructured
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Abstract
The invention discloses silybin nano crystal cosmetics, which comprise surfactant, silybin, oil, essence, preservative and the balance of distilled water. According to an HLB emulsification value, a proper kind of oil phase and a proper kind of emulsifier are selected in a proper ratio for preparing silybin anti-wrinkle and tendering skin cosmetics of water/oil type, oil/water type or other types and different functions. The cosmetics have the characteristics of promoting absorption, making skin texture fine and smooth, removing wrinkles effectively, along with good appearance and the like, and have the effects of long-term moisturizing, resisting ultraviolet injury, making skin more elastic and the like.
Description
Technical field
A kind of cosmetics have been the present invention relates to, particularly silybin nanostructured crystallization cosmetics.
Background technology
Silibinin (Silybin) is obtained through extraction by the fruit of medicinal feverfew Herba Silybi mariani, be the flavonoid native compound, can prevent the damage that chemical toxicant, sitotoxin and medicine etc. cause liver, promote hepatocellular regeneration and reparation, being called as " natural hepatoprotective ", is the common drug of clinical treatment liver and gall diseases; Modern study shows that it also has multiple anti-tumor activity, in studying in the clinical I phase, find the still essentially no any toxicity of silibinin heavy dose of group administration, be natural low toxicity and the nontoxic nonirritant of this product, to the person without any side effect, safe and effective, meet the requirement of modern to cosmetics.
As everyone knows, collagen protein is playing a very important role aspect the generation of inhibition wrinkle of skin, and the cosmetics that contain collagen protein on the market are also a lot.But because the collagen protein ability is very large protein, and have insolublely, be difficult to be absorbed by skin.In addition, free radical scavenger, UV absorbent, some compositions of preserving moisture have all played the effect that suppresses skin aging to a certain extent.The present invention can add all compositions that can suppress skin aging, and the applying nano crystallization technique is very easily absorbed by skin, has improved its crease-resistant antioxidative effect greatly.
Because particle tunnel-effect and small-size effect, the nanocrystal technology can improve the dissolubility of insoluble chemical compound, promote transdermal transfer and absorption, increase adhesiveness and residence time, and have high safety and a good visual effect, therefore, can improve the effect of existing some cosmetics, beautify product.
Summary of the invention
For addressing the above problem, the present invention aims to provide a kind of high bioavailability, high security, low toxic and side effects, sense organ U.S., outstanding effect silibinin cosmetics.
For achieving the above object, silibinin cosmetics provided by the invention are main active and raw material with the silibinin that adopts purity 〉=99%, after adding suitable adjuvant, utilize high pressure homogenization technique to prepare its nanocrystal suspensoid, add to according to a certain percentage immediately in the component of conventional cosmetics and make.
Cosmetics of the present invention are for containing silibinin anti-wrinkle agent and other adjuvant, can add free radical scavenger, UV absorbent, wetting agent isoreactivity composition in addition as required, the defying age of the easy good absorbing effect that forms through the nanotechnology treatments skin-lightening cosmetic of preserving moisture.It comprises following component by weight ratio:
Surfactant 2-45%
Oil 5-7%
Essence 0.15-0.25%
Silibinin 0.5-5%
Antiseptic 0.15-0.35%
Its surplus is a distilled water
Total component is 100%.
Described surfactant is one or more the mixture in lauric acid polyoxyethylene ether, castor oil polyoxyethylene ether, propylene glycol fatty acid fat, alkylphenol polyoxyethylene, castor oil hydrogenated polyoxyethylene ether, tween 80 and the Arlacel-80.
Used oil is triglyceride, isopropyl palmitate fat, ethyl oleate, vaseline, vitamin E oil, Adeps Serpentis, house oil, 2
In crust oil, olive oil, the Oleum Ricini any or several mixture.
Described silibinin cosmetics also can add Pear Power, preserve moisture, other active component of sun-proof, skin care, control wet goods effect.
Special recommendation is prepared into products in most of the cases commonly used such as cleansing milk, day cream, late frost, facial film, sunscreen cream, emollient cream, bath gel, eye woman's persona, foundation cream.
The specific embodiment (body matter)
The present invention will be described in further detail by embodiment, outside used one-tenth office specializes, all explain with percent by weight.The omnipotent frost of embodiment 1 water/oil type
The A phase
Liquid paraffin 18.0
Lanoline 2.0
Vaseline 2.0
Ceresine 7.0
Paraffin 3.0
Anhydrous sorbitol 1.5
The B phase
Silibinin 2
Poloxamer 1
HPMC 0.5
Glycerol 5
Magnesium sulfate 0.2
Distilled water adds to 100%
The C phase
Essence, antiseptic are an amount of
A mutually and B prepare respectively mutually, in preparation process, A heat phase to 70 ℃; B adopts high pressure homogenization method to handle and be prepared into the nanocrystal suspensoid mutually, reheat to 70 ℃, under agitation B is added to A mutually in, stir and be cooled to 40 ℃ and add the C phase again, restir is evenly to room temperature.
The embodiment 2 oil/omnipotent frost of water type
The A phase
Liquid paraffin 23.0
Lanoline 4.0
Cera Flava 2.0
Stearic acid 15.0
Sorbitan trioleate 1.0
The B phase
Silibinin 2
Poloxamer 1
HPMC 0.5
Glycerol 5
Sorbitol 12.2
Distilled water adds to 100%
The C phase
Essence, antiseptic are an amount of
A mutually and B prepare respectively mutually, in preparation process, A heat phase to 70 ℃; B adopts high pressure homogenization method to handle and be prepared into the nanocrystal suspensoid mutually, reheat to 70 ℃, under agitation B is added to A mutually in, stir and be cooled to 40 ℃ and add the C phase again, restir is evenly to room temperature.
Embodiment 3 water/oil/water type wrinkle removing skin moistening late frost
The A phase
Two sad propylene glycol esters 15.0
Glyceryl monostearate 4.5
Stearyl alcohol 2.0
Spermol 1.5
Propylparaben 0.1
The B phase
Silibinin 2.0
Poloxamer 1.0
HPMC 0.5
Glycerol 3.0
Methyl hydroxybenzoate 0.2
Distilled water adds to 100%
The C phase
Essence is an amount of
A is made by water/oil type emulsifying, again the emulsified body that will make join B that high pressure homogenize crosses mutually in, essence is an amount of adding, and promptly makes water/oil/water type wrinkle removing skin moistening late frost.This late frost uses screening characteristics, washing good, no greasy feeling.
Claims (5)
1. silybin nanostructured crystallization cosmetics is characterized in that, comprise that mass percent is: the surfactant of 5%-50%, 3%-30% oil, 0.5%-3% silibinin, an amount of essence, surplus are that distilled water is formed, and total component is 100%.
2. silybin nanostructured cosmetics according to claim 1, it is characterized in that described surfactant is one or more the mixture in lauric acid polyoxyethylene ether, castor oil polyoxyethylene ether, propylene glycol fatty acid fat, alkylphenol polyoxyethylene, castor oil hydrogenated polyoxyethylene ether, tween 80 and the Arlacel-80.
3. silybin nanostructured cosmetics according to claim 1, it is characterized in that used oil is any or several mixture in triglyceride, isopropyl palmitate fat, ethyl oleate, vaseline, vitamin E oil, Adeps Serpentis, house oil, 2 crust oil, olive oil, the Oleum Ricini.
4. according to the described arbitrary silybin nanostructured cosmetics of claim 1-3, it is characterized in that: described silybin nanostructured cosmetics also have preserves moisture, whitens, sun-proof, control oil, removes other active component of functions such as blackhead and acne.
5. according to the described arbitrary silybin nanostructured cosmetics of claim 1-4, it is characterized in that: described silybin nanostructured cosmetics particle diameter is 80nm-2000nm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010295663 CN101966130A (en) | 2010-09-29 | 2010-09-29 | Silybin nano crystal cosmetics and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010295663 CN101966130A (en) | 2010-09-29 | 2010-09-29 | Silybin nano crystal cosmetics and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101966130A true CN101966130A (en) | 2011-02-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010295663 Pending CN101966130A (en) | 2010-09-29 | 2010-09-29 | Silybin nano crystal cosmetics and preparation method thereof |
Country Status (1)
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622748A (en) * | 2015-01-20 | 2015-05-20 | 王雪林 | Nano plant body-wash |
| CN104666126A (en) * | 2015-02-06 | 2015-06-03 | 深圳唯美度生物科技有限公司 | Liquid preparation employing horse oil as active component |
| CN107595688A (en) * | 2017-08-17 | 2018-01-19 | 广州市汇吉科技企业孵化器有限公司 | A kind of sun-screening agent and its application |
| CN108578263A (en) * | 2018-06-20 | 2018-09-28 | 吉林农业科技学院 | Silymarin Skin whitening care cosmetics |
| CN118652831A (en) * | 2024-08-16 | 2024-09-17 | 广州科盈化妆品有限公司 | Silybum marianum-derived plant extracellular vesicles, preparation method thereof and application thereof in soothing oil-controlling products |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101277690A (en) * | 2005-10-03 | 2008-10-01 | 株式会社芳珂 | Abnormal protein removing composition |
| CN101277713A (en) * | 2005-09-29 | 2008-10-01 | 株式会社芳珂 | Composition for acceleration of type I collagen production |
-
2010
- 2010-09-29 CN CN 201010295663 patent/CN101966130A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101277713A (en) * | 2005-09-29 | 2008-10-01 | 株式会社芳珂 | Composition for acceleration of type I collagen production |
| CN101277690A (en) * | 2005-10-03 | 2008-10-01 | 株式会社芳珂 | Abnormal protein removing composition |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622748A (en) * | 2015-01-20 | 2015-05-20 | 王雪林 | Nano plant body-wash |
| CN104666126A (en) * | 2015-02-06 | 2015-06-03 | 深圳唯美度生物科技有限公司 | Liquid preparation employing horse oil as active component |
| CN107595688A (en) * | 2017-08-17 | 2018-01-19 | 广州市汇吉科技企业孵化器有限公司 | A kind of sun-screening agent and its application |
| CN108578263A (en) * | 2018-06-20 | 2018-09-28 | 吉林农业科技学院 | Silymarin Skin whitening care cosmetics |
| CN118652831A (en) * | 2024-08-16 | 2024-09-17 | 广州科盈化妆品有限公司 | Silybum marianum-derived plant extracellular vesicles, preparation method thereof and application thereof in soothing oil-controlling products |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20110209 |