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CN108498390A - A kind of Tibetan book on Chinese herbal medicine extract and the preparation method and application thereof for treating acne - Google Patents

A kind of Tibetan book on Chinese herbal medicine extract and the preparation method and application thereof for treating acne Download PDF

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Publication number
CN108498390A
CN108498390A CN201710103830.0A CN201710103830A CN108498390A CN 108498390 A CN108498390 A CN 108498390A CN 201710103830 A CN201710103830 A CN 201710103830A CN 108498390 A CN108498390 A CN 108498390A
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China
Prior art keywords
parts
tibetan
acne
extract
herbal medicine
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CN201710103830.0A
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CN108498390B (en
Inventor
边巴次仁
白玛卓玛
索朗拉姆
旦增
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Tibet Cheezheng Tibetan Medicine Co Ltd
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Tibet Cheezheng Tibetan Medicine Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/289—Vladimiria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Birds (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention provides a kind of Tibetan book on Chinese herbal medicine extracts and the preparation method and application thereof for treating acne, it is that bulk pharmaceutical chemicals make each efficacy of drugs generate synergistic effect that the extract, which selects the western combined-ear chrysanthemum in river, tall hymenodictyon bark, Elsholtzia densa, to play the effect of prevention and treatment acne to skin, and the extract of the present invention also has anti-corrosion and sterilizing function.The Tibetan book on Chinese herbal medicine extract of the present invention can associate with the various acceptable matrix of cosmetic field is made cosmetics, its to skin action temperature and, can play releive, repair, anti-inflammatory and the effects that sterilization, thus have effects that prevent and treat acne, anti-corrosion well and sterilize.

Description

A kind of Tibetan book on Chinese herbal medicine extract and the preparation method and application thereof for treating acne
Technical field
The invention belongs to Tibetan medicine and pharmacology technical fields, and in particular to a kind of Tibetan book on Chinese herbal medicine extract that treating acne and its preparation side Method and application.
Background technology
Tibetan medicine's pharmacy is the important component of motherland's medicine and pharmacology, with a long history, theoretical complete and deep, abundant in content And it is vast, there is dense Tibetan's characteristic.On the basis of constantly absorbing Chinese medicine pharmaceutical theory, Tibetan medicine's pharmacy gradually develops into For the very complete traditional medicine of a science, method, prescription, drugs, it is said with five sources and is thought for guidance because saying as theoretical core with three Think, the theory of medicine system based on seven substances, the physiology of three dirty things and liver channels and collaterals and pathology theory.It is cured along with motherland Pharmacy being widelyd popularize and popularizing, and the development of Tibetan medicine's pharmacy also gradually tends to be ripe.
Hide the plant medication basis that book on Chinese herbal medicine is Tibetan medicine's pharmacy.It hides herbal (Tibetan medicine plant) and is grown on what China has a vast territory Qinghai-Tibet Platean, it is distinctive that High aititude, the plateau climate of intensive ultraviolet radiation and richly endowed pure land resource impart Tibetan book on Chinese herbal medicine Physiological property and ecological characteristic-cold-resistant and drought resistance are strong, this has benefited from long-term with high, cold and low heat ecological environment The photosynthesis light saturation point that Tibetan book on Chinese herbal medicine is shown in adaptable process increases, light compensation point reduces, thermophilic is relatively low, secretly exhales The features such as rate is relatively low is inhaled, so being conducive to Tibetan book on Chinese herbal medicine makes full use of luminous energy, is also beneficial to the accumulation of its internal dry matter so that It hides the content of material such as pectin, carbohydrate, the hemicellulose in herbal cell to increase, the magical medical treatment of book on Chinese herbal medicine, skin care is hidden to assign And health-care efficacy.Nowadays, " day is pursued increasingly in anti-oxidant, anti-aging, anti-corrosion and anti-inflammatory etc. for skin protection cosmetics Demand so ", energetically research and development have positive realistic meaning and important economic value with the external therapy for hiding book on Chinese herbal medicine is carried out.
Invention content
The purpose of the present invention is to provide a kind of Tibetan book on Chinese herbal medicine extracts for treating acne.
Another object of the present invention is to provide a kind of preparation methods of the herbal extract in Tibetan that treating acne.
It is still another object of the present invention to provide a kind of herbal extract the answering in preparing cosmetics in Tibetan for treating acne With.
For this purpose, the present invention realize the technical solution that uses of above-mentioned purpose for：
A kind of Tibetan book on Chinese herbal medicine extract for treating acne, bulk pharmaceutical chemicals in terms of parts by weight including：
1~70 part of the western combined-ear chrysanthemum in river；5~50 parts of tall hymenodictyon bark；5~40 parts of Elsholtzia densa.
Preferably, the bulk pharmaceutical chemicals of the herbal extract in Tibetan of the treatment acne in terms of parts by weight including：
5~50 parts of the western combined-ear chrysanthemum in river；10~45 parts of tall hymenodictyon bark；10~35 parts of Elsholtzia densa；Or
20~66 parts of the western combined-ear chrysanthemum in river；15~30 parts of tall hymenodictyon bark；10~40 parts of Elsholtzia densa.
It is highly preferred that the bulk pharmaceutical chemicals of the herbal extract in Tibetan of the treatment acne in terms of parts by weight including：
46 parts of the western combined-ear chrysanthemum in river；30 parts of tall hymenodictyon bark；24 parts of Elsholtzia densa.
In order to keep the prevention and treatment acne effect of the herbal extract in the Tibetan of the present invention more prominent, in the base of above-mentioned prescription It can further include on plinth one or more in the following raw material medicine：
5~35 parts of rhodiola root, 5~15 parts of Lagotis glauca, 5~40 parts of barberry skin, 5~25 parts of Chinese podophyllum root, Rhizoma Acori Calami 5~70 Part, 5~70 parts of radix scutellariae, 5~15 5~15 parts of part, mao fringe elscholtiza of Sievers wormwood, 5~15 parts of lanatechead saussurea herb with flower, 5~15 parts of sea-buckthorn, radix jurineae 5~15 parts.
The western combined-ear chrysanthemum in river, the also referred to as western climbing groundsel in river are a kind of Tibetan medicines, and Tibetan medicine is entitled " Yu Guxing ",《Jingzhubencao》Note It carries to protect as the beautiful ancient emerging loud, high-pitched sound of Tibetan medicine together with the Qinghai-Tibet Platean such as the western climbing groundsel in river and Senecio dianthus production congener and use, have clear The special efficacy of thermal detoxification.《Chinese Plants will》With《Tibetan medicine will》It records it and controls the work(such as sore, synthetism, all heat of clearing liver courage with clearing heat and detoxicating Effect, inflorescence or all herbal medicine, cure mainly the diseases such as wound inflammation, swelling, acute conjunctivitis, dermatitis, boil, traumatic injury.
Elsholtzia densa, containing vitamin A, vitamin B12, palmitic acid, oleic acid, linoleic acid, myristic acid and sitosterol etc. it is a variety of Active ingredient has replenishing and activating blood, the effect of antibacterial anti-inflammatory.It can promote blood circulation, promote cell metabolism, inhibit black It is plain calm, nourishing and skin nutrition.Nourishing additive agent as cosmetics can moisturize the skin, and prevent from having dry skin, and keep skin white It is tender, slowing down skin aging.
Tall hymenodictyon bark, Tibetan language is entitled " first rubber prosperous autumn ", has clearing heat and detoxicating, dispelling wind and eliminating dampness, cooling blood and hemostasis, desinsection is antipruritic, controls Treat dermatitis and other effects.
Rhodiola root,《Sheng Nong's herbal classic》、《Four doctor's allusion quotations》、《Jingzhubencao》、《Compendium of Materia Medica》Etc. in many ancient books and records Have to rhodiola root recorded.There is rhodiola root anti-aging, antifatigue, resist oxygen lack, adjusting to be immunized, adjust central nervous system, carry The special efficacies such as high mental, enhancing muscle power.
Lagotis glauca, Tibetan language is entitled " flood even ", according to Tibetan medicine allusion quotation by《Jingzhubencao》It records, Tibetan medicine Honglian bitter cold, it can heat-clearing solution Inverse decompression is put down in poison, promoting circulation of blood menstruation regulating.There are heat, noxious heat in the blood system, acute, chronic hepatitis, irregular menstruation for the five internal organs.
Barberry skin, the drying endothelium of several barberries of Berberidaceae plant.With clear place heat, relieving heat toxin holds back the effect of yellow water.
Chinese podophyllum root is Berberidaceae Sinopodophyllum Sinopodophyllum herbaceos perennials, and effect has external application to control tinea, Skin disease, impetigo etc..
Radix jurineae, is a kind of Chinese medicinal herb medicament, is mainly used for skin care item in cosmetic field, brightens dew, the makeups such as bath agent In product, skin can be made to keep delicate, it is moist smooth, there is good skin nutrition, prevent the functions such as wrinkle, killed since it has Bacterium activity, while being a kind of excellent skin treating acne agents.
Radix scutellariae can treat all skin diseases as caused by damp and hot, such as dermatitis, eczema and erythema class illness.Have anti-inflammatory And antiallergic action.Can inhibit cutaneous anaphylaxis, histamine dermoreaction, in whitening dentifrice application can reduce melanin life At.There is broad-spectrum antibacterial action, has different degrees of inhibiting effect to the therapeutic fungi of a variety of skins.
Rhizoma Acori Calami has the effects that anti-inflammatory, antiviral.Skin metabolism function can be improved, also increase capillary Permeability, soft and smooth rough skin, prevents skin aging.Ultraviolet light can also be absorbed simultaneously, experiments have shown that there is inhibition melanin The effect of formation is mainly used for treating acne, prevents acne and sun care preparations lotion and cream.
Sievers wormwood, herbaceos perennial, its great medical value in 107 kinds of world sengreen, is rare Medicinal plant；China is mainly grown among 3500 meters of height above sea level or more high mountain.Main component is Sievers wormwood glucoside and tyrosol, is had in addition Polyphenol, protein, fat, tannic acid, flavone compound and micro- volatile oil, the micro member such as Yi Jitie, zinc, tin, molybdenum, manganese Element.Scientific research proves：Sievers wormwood anti anoxia, it is antifatigue, prevent acne, adjust human immunity etc. be superior to ginseng, Wilsonii.
Hair fringe elscholtiza, Tibetan medicine；Soft match is cut to protect：Aerial part takes stomach invigorating orally, and pruitus is controlled in external application, is seen《Qinghai-Tibet medicine mirror》. Soft match is ceased to protect：Annual shoot leaf and inflorescence cure mainly anus parasitosis, tire parasitosis, skin parasitosis, stomach and intestine parasitosis, external application can insect preventing rope, See《Chinese Tibetan medicine》.Complete stool treats indigestion, pruitus, sees《Yunnan province will》.
Lanatechead saussurea herb with flower also known as saussurea involucrata hide name " proper lamb element bar ", are a kind of Tibetan's commonly folk medicines.Related experiment shows Flavones in lanatechead saussurea herb with flower, which not only has, removes free radical and oxidation resistant ability, also granulation tissue is inhibited to be formed, analgesia, anti-inflammatory Effect.The effects that preventing skin aging, resisting damage of the ultraviolet light to skin, play moist, sterilization, anti-inflammatory, myogenic.
Sea-buckthorn is a kind of huge industrial crops of potentiality to be exploited, and fruit, leaf, root, seed can all be used as medicine.Eightth century of Christian era hide Medicine book《Month king's medicine is examined》In detailed record just has been done to the effect of sea-buckthorn, modern research shows that a large amount of dimensions contained in Seabuckthorn Oil Raw element E, vitamin A, flavones and SOD active constituents, can effectively prevent free radical, while having to propionibacterium acnes and inhibiting Its effect infected, spread unchecked repairs and is damaged skin, restores skin normally update and the circulatory system.
The preparation method of the herbal extract in Tibetan for the treatment of acne of the present invention, includes the following steps：
Above-mentioned raw materials medicinal powder is extracted 3~5 times after broken with the extractant of 0.5~50 times of weight, 0.5~2 hour every time, is closed And extracting solution, decoloration, it is concentrated into after relative density is 1.10~1.30 and is drying to obtain.
Preferably, the weight ratio of the extractant and the bulk pharmaceutical chemicals is 6~20.
Preferably, the extractant is mixed by the component of following parts by weight：
400~600 parts of water；400~600 parts of organic solvent；0~10 part of solubilizer；
0~25 part of surfactant；0~5 part of deaeration agent；0~50 part of co-penetrant；
0~10 part of thickener；0~15 part of tackifier.
Wherein, organic solvent can be alcohols：Such as methanol, ethyl alcohol, ethylene glycol, propylene glycol, glycerine, 1,3-BDO, benzene Methanol etc., preferably ethyl alcohol, propylene glycol, glycerine, 1,3-BDO；
Organic solvent can also be ketone：Such as acetone, butanone etc.；
Organic solvent can also be ethers：Such as ether, tetrahydrofuran, ethylene glycol monobutyl ether；
Organic solvent can also select liquid grease：Such as caprylic capric glyceryl ester, ethyl acetate, C12~C16Benzoic acid Ester, low viscosity synthetic oil (viscosity is in 100cps or less), liquid low viscosity ester (viscosity is in 100cps or less), preferably acetic acid Ethyl ester, C12~C16Benzoic ether, caprylic capric glyceryl ester；
Organic solvent can also be vegetable oil：Such as olive oil, soybean oil, sesame oil, rapeseed oil, rice bran oil, rice germ oil, Wheat-germ oil, Seabuckthorn Oil, palm oil, linseed oil, avocado oil, persic oil, carrot oil, candlenut oil, grape seed oil, mountain Camellia oil, safflower oil, apricot kernel oil, caryophyllus oil, stone rose oil, corn oil, turtledove wheat oil, sunflower oil, peanut oil, hazelnut oil, breast wood Fruit oil, rose oil, cottonseed oil, camellia oil, preferably stone rose oil, sunflower oil, safflower oil；
Organic solvent can also be mineral oils：Such as white oil, petroleum ether, kerosene, Permethyl 99A, the low boiling points such as isohexadecane Alkane；
Organic solvent can also be aromatic compound：Such as toluene, the low-boiling compounds such as ethylbenzene；Or other class compounds Or composition：Such as dimethyl sulfoxide, carbon disulfide, hydrogen peroxide.
Above-mentioned solubilizer can select ethylene glycol monobutyl ether, benzyl alcohol, dimethyl sulfoxide etc..
Above-mentioned surfactant can be：
Anion surfactant：Such as metal carboxylate, general formula RCOOM, wherein M represent metal ion, and R is containing 11~17 The alkyl of a carbon atom；Sulfonates；Sulfuric ester salt；
Cationic surfactant：Such as amine salt；Quaternary ammonium salt；Pyridine salt etc.；
Nonionic surfactant：Such as polyethylene glycol (PEG) or polyoxyethylene (POE) type；Polyol type and high molecular form Face activating agent etc.；
Amphoteric surfactant：Such as betaines；Amino acids；Imidazolines etc..
Above-mentioned deaeration agent can be macromolecule deaeration agent, such as silicone oil.
Above-mentioned co-penetrant can be inorganic salts such as sodium chloride, potassium chloride, zinc sulfate, sodium sulphate etc..
Above-mentioned thickener can be laruyl alcohol, stearic acid, ethoxylated dodecyl alcohol etc..
Above-mentioned tackifier can be sodium chloride, carbopol, polyethylene glycol stearate diester, lauric acid diethyl amide etc..
The Tibetan book on Chinese herbal medicine extract of the present invention is associated with the various acceptable matrix of cosmetic field, according to common process system At face cream, facial treatment milk, smoothing toner, gel, Essence, facial mask, hand lotion, body frost, facial cleanser, aerosol, spraying etc. are more The cosmetics of kind form.
Application of the herbal extract in Tibetan for the treatment of acne of the present invention in the cosmetics for preparing treatment acne.
Preferably, the dosage for hiding herbal extract accounts for 0.3~10wt% of the cosmetics gross mass.
Preferably, the dosage form of the cosmetics is frost, lotion, water, gel, facial mask, aerosol or spraying.
Compared with prior art, above-mentioned technical proposal of the invention has the following advantages that：
1, the Tibetan book on Chinese herbal medicine extract for the treatment of acne provided by the invention, the western combined-ear chrysanthemum in selection river, tall hymenodictyon bark, Elsholtzia densa are Bulk pharmaceutical chemicals, these combinations for hiding book on Chinese herbal medicine make each efficacy of drugs generate synergistic effect, to play prevention and treatment Cuo to skin The effect of sore, and the Tibetan book on Chinese herbal medicine extract of the present invention also has anti-corrosion and sterilizing function.
2, the preparation method of the herbal extract in Tibetan for the treatment of acne provided by the invention, by using at least by water and organic The extractant of solvent composition extracts each bulk pharmaceutical chemicals, can not only obtain the active constituent in bulk pharmaceutical chemicals to the maximum extent, and And each efficacy of drugs can also be made to generate synergistic effect, so that it is guaranteed that the extract obtained work(with good prevention and treatment acne Effect.And the preparation method of the present invention is easy, and operability is strong, is conducive to industrialized production.
3, the cosmetics of the Tibetan herbal extract provided by the invention containing above-mentioned treatment acne, to skin action temperature and, Can play releive, repair, anti-inflammatory and the effects that sterilization, thus with prevention and treatment acne well, anti-corrosion and sterilization Effect.
Specific implementation mode
Technical scheme of the present invention will be clearly and completely described below, it is clear that described embodiment is this hair Bright a part of the embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not having There is the every other embodiment obtained under the premise of making creative work, shall fall within the protection scope of the present invention.In addition, below Involved technical characteristic as long as they do not conflict with each other can be mutual in described different embodiments of the present invention In conjunction with.
In following embodiments and comparative example, 1g represents 1 parts by weight.
Embodiment 1
Draft is used after the western combined-ear chrysanthemum 45g in river, tall hymenodictyon bark 15g, Elsholtzia densa 10g and hair fringe elscholtiza 15g are mixed and crushed The extractant of 12 times of weight extracts 4 times, each 1h, merges extracting solution, is decolourized to limpid weak yellow liquid, be concentrated into molecular sieve Relative density is dry after being 1.10, obtains hiding herbal extract.
Extractant in the present embodiment is mixed by following component：Water 500g, ethyl alcohol 500g, salt 2g, dodecyl Sodium sulphate 5g, silicone oil 2g and laruyl alcohol 2g.
Embodiment 2-12
The preparation method of the herbal extract in Tibetan in embodiment 2-12 is similar to Example 1, but the bulk pharmaceutical chemicals of each embodiment Composition, extractant composition and specific process parameter are see table 1.
Bulk pharmaceutical chemicals composition, extractant composition and the specific process parameter of 1 embodiment 2-12 of table
Embodiment 13
Will the embodiment of the present invention 3 it is obtained hide book on Chinese herbal medicine extract 3g and stearic acid 10g, triethanolamine 2g, sodium hydroxide 2g, Glycerine 10g, essence 0.5g mixing, then deionized water is added to 100g into mixture, toilet cream is made according to common process.
Embodiment 14-20
The preparation method is the same as that of Example 13 for toilet cream in embodiment 14-20, but only difference is that Tibetan used this Careless extract is corresponding in turn in embodiment 4-10.
Embodiment 21
Will the embodiment of the present invention 9 it is obtained hide book on Chinese herbal medicine extract 3g and stearic acid 10g, triethanolamine 2g, sodium hydroxide 2g, Glycerine 10g, essence 0.5g and preservative 0.5g mixing, then deionized water is added to 100g, according to common process into mixture Toilet cream is made.
Embodiment 22
By the Tibetan book on Chinese herbal medicine extract 3g obtained of the embodiment of the present invention 10 and stearic acid 10g, triethanolamine 2g, sodium hydroxide 2g, glycerine 10g, essence 0.5g and preservative 0.5g mixing, then deionized water is added to 100g, according to conventional work into mixture Toilet cream is made in skill.
Comparative example 1
The preparation method of the herbal extract in Tibetan in this comparative example is similar to Example 9 but only difference is that former Expect that medicine is only the western combined-ear chrysanthemum 46g in river.
Comparative example 2
The preparation method of the herbal extract in Tibetan in this comparative example is similar to Example 9 but only difference is that former Material medicine is river western combined-ear chrysanthemum 46g and tall hymenodictyon bark 30g.
Comparative example 3
The preparation method of the herbal extract in Tibetan in this comparative example is similar to Example 9 but only difference is that former Material medicine is river western combined-ear chrysanthemum 46g and Elsholtzia densa 24g.
1 acne dorsalis therapeutic effect of experimental example is tested
The embodiment of the present invention 1~12 and the extract obtained each 5g of comparative example 1-3 are taken respectively, and are diluted to respectively with glycerine 50g, it is spare；
Normal 150 people of trial volunteer of choosing health, is divided into 15 groups, every group of 10 people, the age at 35 years old to 40 years old, For back 2 acnes every square centimeter；
It gives 15 groups of subjects to smear respectively with above-mentioned extract dilution, two times a day, smears 90 days, be only applied to every time Patient part.
Testing result：After 90 days check test crowd, therapeutic evaluation from acne lesions quantity, skin lesion type, cutaneous lesion, 4 aspect overall merits of subjective symptoms, specifically, clinical cure：Skin lesion disappears, or only leaves a little pigmentation, feels disease Shape disappears；It is effective：Skin lesion is largely subsided, and subjective symptoms is substantially reduced；It improves：Skin lesion partial remission, subjective symptoms improve；Nothing Effect：Skin lesion recession unobvious counter are shown in exacerbation.Total effective rate=clinical cure rate+obvious effective rate+improvement rate.
In this experimental example, the total effective rate for having smeared the extract obtained dilution of embodiment 1~12 is 86~92%, Wherein the total effective rate of embodiment 2,4,9 may be up to 91%, 90%, 92% respectively；And 1~3 gained extraction of comparative example is smeared The whelk of 30 subject's faces of the dilution of object is slightly taken on a new look, the total effective rate of comparative example 1~3 is respectively 40%, 43%, 45%, it is seen that embodiment group curative effect is substantially better than comparative example group.
Test result shows that the herbal extract in Tibetan of the invention has good treatment acne effect to the skin of people.
The facial whelk therapeutic effect test of experimental example 2
The embodiment of the present invention 1~12 and the extract obtained each 5g of comparative example 1-3 are taken respectively, and are diluted to respectively with glycerine 50g, it is spare；
It is subject to select 150 people of whelk patient, is divided into 15 groups, every group of 10 people, the age, face was often put down at 18 years old to 28 years old Square centimetre of 2 whelks；
Giving 15 groups of subjects to smear face respectively with above-mentioned extract dilution has the position of whelk, two times a day, smears 90 days；
Testing result：Therapeutic evaluation overall merit in terms of whelk quantity, affected part rash point and scar, subjective symptoms 3, Clinical cure:Whelk disappears, and face disappears without rash point and scar, subjective symptoms；It is effective:Affected part whelk disappears or every square Centimetre 2 whelks are less than, leave a little papule, subjective symptoms improves；In vain：Whelk is not reduced, and affected part is without improvement.Always have Efficiency=clinical cure rate+obvious effective rate.
In this experimental example, 120 subject faces of the extract obtained dilution of the embodiment of the present invention 1~12 have been smeared The whelk in portion has different degrees of improvement, and the total effective rate of experimental example is 88~95%, and wherein embodiment 2,4,9 always has Efficiency may be up to 90%, 92%, 95% respectively；And 30 subjects of the extract obtained dilution of comparative example 1~3 are smeared The whelk of face is slightly taken on a new look, and the total effective rate of comparative example 1~3 is respectively 40%, 42%, 41%, and embodiment group curative effect is bright It is aobvious to be better than comparative example group.
Test result shows that the herbal extract in Tibetan of the invention has whelk certain therapeutic effect.
Experimental example 3 prevents acne measure of merit
The embodiment of the present invention 1~12 and the extract obtained each 5g of comparative example 1-3 are taken respectively, and are diluted to respectively with glycerine 50g, it is spare；
Choosing health 150 people of normal trial volunteer, is divided into 15 groups, every group of 10 people；
It gives 15 groups of subjects to smear face respectively with above-mentioned extract dilution, two times a day, smears 66 days；
Testing result：Therapeutic evaluation from whether overall merit in terms of acne, skin condition, subjective symptoms 3, it is clinical Effectively:Experimental period, existing acne disappeared, and did not occurred new acne, and skin is fine and smooth, glossy before skin is relatively smeared, elasticity It is good；It is effective:Experimental period skin lesion is largely subsided, and does not occur new acne lesions；It improves:Skin lesion partial remission does not occur new Acne lesions, subjective symptoms improve；In vain:Skin lesion recession unobvious grow new acne.Total effective rate=clinical effective rate+ Obvious effective rate+improvement rate.
120 subjects for having smeared the extract obtained dilution of the embodiment of the present invention 1~12 in this experimental example compared with Skin is fine and smooth, glossy before smearing, and elasticity is good, and the total effective rate of experimental example is 82~90%, and wherein embodiment 2,4,9 is total It is efficient to may be up to 85%, 87%, 90% respectively；And smeared the extract obtained dilution of comparative example 1~3 30 are tested Skin quality is slightly taken on a new look before person relatively smears, and the total effective rate of comparative example 1~3 is respectively 43%, 45%, 45%, and embodiment group is treated Effect is substantially better than comparative example group (P<0.01).
Test result shows that the herbal extract in Tibetan of the invention has the skin of people and prevents acne effect well.
4 antisepsis and sterilization measure of merit of experimental example
10 are added respectively into toilet cream made from 13-22 of the embodiment of the present invention15Escherichia coli and propionibacterium acnes To carry out preservation challenge experiment.
As a result, it has been found that toilet cream (being not added with preservative) made from embodiment 13-20 was examined at the 7th day does not measure micro- life Object, and at 28 days, microorganism can not count toilet cream made from embodiment 21-22 (addition preservative).
Test result shows that the herbal extract in Tibetan of the invention has the effect of killing microorganism.
Obviously, the above embodiments are merely examples for clarifying the description, and does not limit the embodiments.It is right For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or It changes.There is no necessity and possibility to exhaust all the enbodiments.And it is extended from this it is obvious variation or It changes still within the protection scope of the invention.

Claims (10)

1. a kind of Tibetan book on Chinese herbal medicine extract for treating acne, bulk pharmaceutical chemicals in terms of parts by weight including：
1~70 part of the western combined-ear chrysanthemum in river；5~50 parts of tall hymenodictyon bark；5~40 parts of Elsholtzia densa.
2. the Tibetan book on Chinese herbal medicine extract for the treatment of acne according to claim 1, which is characterized in that
5~50 parts of the western combined-ear chrysanthemum in river；10~45 parts of tall hymenodictyon bark；10~35 parts of Elsholtzia densa；Or
20~66 parts of the western combined-ear chrysanthemum in river；15~30 parts of tall hymenodictyon bark；10~40 parts of Elsholtzia densa.
3. the Tibetan book on Chinese herbal medicine extract for the treatment of acne according to claim 1 or 2, which is characterized in that
46 parts of the western combined-ear chrysanthemum in river；30 parts of tall hymenodictyon bark；24 parts of Elsholtzia densa.
4. treating the Tibetan book on Chinese herbal medicine extract of acne according to claim 1-3 any one of them, which is characterized in that further include following It is one or more in bulk pharmaceutical chemicals：
5~35 parts of rhodiola root, 5~15 parts of Lagotis glauca, 5~40 parts of barberry skin, 5~25 parts of Chinese podophyllum root, 5~70 parts of Rhizoma Acori Calami, Huang 5~70 parts of a kind of reed mentioned in ancient books, 5~15 5~15 parts of part, mao fringe elscholtiza of Sievers wormwood, 5~15 parts of lanatechead saussurea herb with flower, 5~15 parts of sea-buckthorn, radix jurineae 5~15 Part.
5. a kind of preparation method of the herbal extract in Tibetan of claim 1-4 any one of them treatment acne, including walk as follows Suddenly：
It is extracted 3~5 times with the extractant of 0.5~50 times of weight after the bulk pharmaceutical chemicals are crushed, 0.5~2 hour every time, merging carried Liquid is taken, is decolourized, is concentrated into after relative density is 1.10~1.30 and is drying to obtain.
6. a kind of preparation method of the herbal extract in the Tibetan of the treatment acne described in claim 5, which is characterized in that the extraction The weight ratio of agent and the bulk pharmaceutical chemicals is 6~20.
7. a kind of preparation method of the herbal extract in Tibetan for the treatment of acne described in claim 5 or 6, which is characterized in that described Extractant is mixed by the component of following parts by weight：
400~600 parts of water；400~600 parts of organic solvent；0~10 part of solubilizer；
0~25 part of surfactant；0~5 part of deaeration agent；0~50 part of co-penetrant；
0~10 part of thickener；0~15 part of tackifier.
8. claim 1-4 any one of them treats the herbal extract in Tibetan of acne in the cosmetics for preparing treatment acne Using.
9. applying according to claim 8, which is characterized in that the dosage for hiding herbal extract accounts for the total matter of the cosmetics 0.3~10wt% of amount.
10. applying according to claim 8 or claim 9, which is characterized in that the dosage form of the cosmetics be frost, lotion, water, gel, Facial mask, aerosol or spraying.
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110037974A (en) * 2019-01-21 2019-07-23 四川省中医药科学院 A kind of topical composition and preparation method thereof with skin-care effect
CN110200890A (en) * 2019-01-16 2019-09-06 四川省中医药科学院 A kind of cosmetics and preparation method thereof containing tetrahydro curcumin
CN110200881A (en) * 2019-02-26 2019-09-06 四川省中医药科学院 A kind of cosmetics and preparation method thereof containing tetrahydro curcumin
CN110772467A (en) * 2019-11-28 2020-02-11 西藏葛如吒生物科技有限公司 Tibetan medicine toothpaste

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110200890A (en) * 2019-01-16 2019-09-06 四川省中医药科学院 A kind of cosmetics and preparation method thereof containing tetrahydro curcumin
CN110037974A (en) * 2019-01-21 2019-07-23 四川省中医药科学院 A kind of topical composition and preparation method thereof with skin-care effect
CN110200881A (en) * 2019-02-26 2019-09-06 四川省中医药科学院 A kind of cosmetics and preparation method thereof containing tetrahydro curcumin
CN110772467A (en) * 2019-11-28 2020-02-11 西藏葛如吒生物科技有限公司 Tibetan medicine toothpaste

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