CN101700016A - Bactericidal composite used for preventing and treating powdery mildew - Google Patents
Bactericidal composite used for preventing and treating powdery mildew Download PDFInfo
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- CN101700016A CN101700016A CN200910310640A CN200910310640A CN101700016A CN 101700016 A CN101700016 A CN 101700016A CN 200910310640 A CN200910310640 A CN 200910310640A CN 200910310640 A CN200910310640 A CN 200910310640A CN 101700016 A CN101700016 A CN 101700016A
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- fluoxastrobin
- powdery mildew
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Abstract
The invention belongs to the technical field of the compounding of pesticide, and in particular relates to a bactericidal composite used for preventing and treating powdery mildew. In the bactericidal composite, azoxystrobin and pyrimidine class bactericide are compounded, wherein the weight ratio of the azoxystrobin to the pyrimidine class bactericide is 20:1-1:20. The bactericidal composite is used for preventing and treating the powdery mildew in agriculture, such as melon and cereal crops and the like, can enhance the preventing and treating effect obviously and has a better function for overcoming and delaying the drug resistance of pathogenic bacteria.
Description
Technical field
The invention belongs to the technical field of agriculture chemical compounding, be specifically related to a kind of bactericidal composition that is used to prevent and treat powdery mildew, be used for preventing and treating the powdery mildew on the agriculturals such as melon, cereal crop.
Background technology
The plant pathogenic fungi powdery mildew is absolute specialization bacterial parasite, expand in the green portion of plant after infecting plant, its brood body hypergene is at the outside white powder layer that forms of plant, except that absorbing plant nutrition, also influence photosynthesis of plants, cause plant weak or dead, because the conidium of powdery mildew is propagated with air-flow, bacterium amount is big, and variation is fast, causes the large watershed generation of disease, large-area prevention and control, a large amount of medication.In some serious places of powdery mildew harm, common bactericide such as tpn, thiophanate-methyl, use has not had any effect separately, and triazolones etc. have also caused very serious resistance, and have been easy to generate poisoning owing to large-area application.
Go up the powdery mildew that produces resistance for control agricultural, a kind of way is to release the new component that new and existing kind do not have cross resistance, still, the development cost height of new active ingredient, the construction cycle is long, and forever all less than the speed of germ generation resistance.Additive method such as crop allocation adjustment, different agricultural chemicals are rotated etc., in practical operation, are difficult to really play obvious effects.
The composition of different cultivars carries out composite, is the common way of preventing and treating the resistance germ, according to practical application effect, judge certain composite be synergy, addition or antagonism.Composite effect is well filled a prescription, owing to obviously improved actual control efficiency, reduced the usage amount of agricultural chemicals, thereby delayed the drug-fast generation of germ greatly, and be the important means of integrated control disease.
Fluoxastrobin (Azoxystrobin) is a kind of new and effective beta-methoxy acrylic ester bactericide, has protection, treats, roots out, infiltration, systemic activity, destroys the synthetic and loss of life power of the energy of germ by the respiration that suppresses germ.Fluoxastrobin has the bactericidal activity of wide spectrum, tens of kinds of diseases such as nearly all Mycophytes (Ascomycetes, Basidiomycetes, Oomycete and Fungi Imperfecti) disease such as powdery mildew, rust, scab, net blotch, downy mildew, rice blast all there is good active, be applicable to various crop such as cereal, vegetables, paddy rice, fruit tree and economic crops, and have good crop safety and very outstanding Environmental compatibility.Because its drug cost height, the application of this medicine is subjected to certain restriction, uses not extensive, cause waste to outstanding resource, the action site of this bactericide is very single in addition, and germ can produce adaptive variation to medicament, the preventive effect of medicament is reduced even invalid and cause the drug-fast generation of germ, in follow-up use, need to strengthen dosage, increase spray medicine number of times, make residue of pesticide improve, influence environment etc., thereby cause a series of vicious circle.The resistance of Fluoxastrobin is found as yet in the field at present, but is had the relevant report that produces resistance in Europe with veriety.
The phonetic phenol of second (Ethirimol) chemical name is 5-butyl-2-ethylamino-4-hydroxyl-6-methylpyrimidine; bupirimate (Bupirimate) chemical name 5-butyl-2-ethylamino-6-methylpyrimidine-4-base dimethylamino sulfuric ester; both all belong to the miazines bactericide; it is adenosine deaminase inhibitors; the strong systemic activity of tool; root through plant; stem; leaf can conduct to young leaves after absorbing; all has protective effect in the crop whole growth phase; but because the two long-term use separately; germ produces resistance to it; separately result of use is unsatisfactory, and causes the waste of medicine and to the pollution of environment.
At present, still nobody reported in the composite and application of Fluoxastrobin and miazines bactericide.
Summary of the invention
Purpose of the present invention is exactly to provide a kind of bactericidal composition that is used to prevent and treat powdery mildew at the problem of above-mentioned existence, said composition is the combination sterilization composition that contains Fluoxastrobin and miazines bactericide, be used for preventing and treating the powdery mildew on the agriculturals such as melon, cereal crop, can obviously improve control efficiency, and the pesticide resistance that overcomes and delay pathogen is had better action.
Among the present invention, involved weight, for example the weight of Fluoxastrobin, miazines bactericide, active ingredient all refers to the weight of rolling over after hundred, i.e. the weight of active principle.
The bactericidal composition that is used to prevent and treat powdery mildew of the present invention, its active ingredient comprise Fluoxastrobin and miazines bactericide, and the weight ratio of the two is Fluoxastrobin: miazines bactericide=20: 1～1: 20.
As preferably, described Fluoxastrobin and miazines bactericide weight ratio are Fluoxastrobin: miazines bactericide=5: 1～1: 5.
Wherein, described miazines bactericide is that the phonetic phenol of second is or/and bupirimate.
In the composition of the present invention, the weight percentage of its described active ingredient is 1%～80%.
The formulation of said composition comprises wetting powder, suspending agent or water dispersible granules, and described composition adds auxiliary agent and excipient, makes needed formulation according to the production technology that those skilled in the art all know.
Beneficial effect of the present invention is: with Fluoxastrobin and the bactericide compounded use of miazines, both show good synergistic effect in certain ratio range, compare with single agent, obviously improved bactericidal effect, had a significant effect for the powdery mildew of preventing and treating on the agricultural, and, two kinds of active substance structures in the composition differ bigger, there is not cross resistance, is mixed and uses the resistance effectively to delay single agent to take place and development, the resistance that overcomes and delay pathogen is had effect preferably.Medicine of the present invention is composite, its effect that plays is many-sided, at first, good cooperative synergism effect, the effect of preventing and treating powdery mildew obviously improves, thereby reduce the medicament usage amount, simultaneously effectively delayed the pesticide resistance problem of germ, thereby efficiently solved the problem of germ resistance, in addition, this is composite also to get up the abundant reasonable use of Fluoxastrobin, its advantage is well brought into play, in addition, compositely brought a series of optimum effect by this, good drug effect, reduce pesticide dosage, reduce residue of pesticide, reduce peasant's cost and labour, delay the germ resistance, improve environmental pollution.In a word, the present invention efficiently solves the problem of above-mentioned existence, powdery mildew there is good control efficiency, problems such as the resistance generation that can also effectively avoid using Fluoxastrobin, the agent of miazines list to bring, drug effect reduction, prolong the life cycle and the service life of single agent, better with the performance of the drug effect of single agent.
Measured the indoor virulence of the composite mixture of Fluoxastrobin and the phonetic phenol of second, the different proportionings of bupirimate at indoor employing seedling pot-culture method to the white powder germ.Promptly at the greenhouse pot culture cucumber seedling to the 2-3 leaf phase, carrying out foliar spray by the designer drug agent dose handles, inoculation test pathogen after 24 hours, and the cultivation of in incubator, preserving moisture, investigation result when the blank of not dispenser is fully fallen ill, disease classification, preventive effect computational methods are all with reference to the People's Republic of China (PRC) [pesticide field efficacy medicine test criterion].Carry out statistical analysis with the DPS data processing software, calculate the EC50 of each medicament, adopt the abundant method calculating co-toxicity coefficient of Sun Yun (CTC) to estimate and use effect with, the CTC value has synergistic effect greater than 120 o'clock mixtures, less than 80 o'clock be antagonism, have summation action in the time of between 80～120.
The EC50*100 of the EC50/B agent of toxicity index TI (B)=standard agent A
The EC50*100 of the EC50/AB of actual toxicity index ATI (AB)=A
Theoretical toxicity index TTI (AB)=percentage+TI (B) * B the percentage in mixture of TI (A) * A in mixture
Co-toxicity coefficient CTC=ATI (AB)/TTI (AB) * 100
Result of the test is as follows:
The phonetic phenol list of table 1 Fluoxastrobin and second mixture is to the toxicity test of powdery mildew of cucumber bacterium
| Reagent agent | The active ingredient weight ratio | ??EC50(mg/L) | Co-toxicity coefficient (CTC) |
| Fluoxastrobin | ??- | ??1.56 | ??- |
| The phonetic phenol of second | ??- | ??1.21 | ??- |
| Fluoxastrobin: the phonetic phenol of second | ??20∶1 | ??1.18 | ??260.81 |
| Fluoxastrobin: the phonetic phenol of second | ??10∶1 | ??1.02 | ??298.04 |
| Fluoxastrobin: the phonetic phenol of second | ??5∶1 | ??0.87 | ??342.12 |
| Fluoxastrobin: the phonetic phenol of second | ??1∶1 | ??0.69 | ??395.04 |
| Fluoxastrobin: the phonetic phenol of second | ??1∶5 | ??0.68 | ??369.70 |
| Fluoxastrobin: the phonetic phenol of second | ??1∶10 | ??0.84 | ??294.09 |
| Fluoxastrobin: the phonetic phenol of second | ??1∶20 | ??1.06 | ??230.76 |
By table 1 as seen, the phonetic phenol of Fluoxastrobin and second is composite, the powdery mildew of cucumber bacterium had good indoor virulence, the CTC value of seven proportionings is all above 120, show that these two bactericide have good synergistic effects under this proportioning, simultaneously also as can be seen in composition different its synergistic effects along with the phonetic phenol ratio of Fluoxastrobin and second also be different, mixed ratio synergy between 5: 1～1: 5 is particularly remarkable.
When Fluoxastrobin and bupirimate carry out combine experiment with aforementioned proportion, show the antibacterial rule identical with the phonetic phenol of second, the synergistic effect to the powdery mildew of cucumber bacterium under 5: 1～1: 5 ratio is comparatively obvious.
Embodiment
Be described further below in conjunction with the combination sterilization composition of specific embodiment to Fluoxastrobin of the present invention and miazines bactericide, but the present invention is not limited thereto, the formulation preparation method among the embodiment is conventional method.
The phonetic phenol suspending agent of embodiment 1:21% Fluoxastrobin second comprises following component by weight:
Fluoxastrobin (folding hundred, down together) 20%
The phonetic phenol 1% of second
Alkylaryl polyoxyethylene polyoxypropylene ether 5%
Poly-naphthaldehyde sulfonate sodium 5%
Ethylene glycol 3%
Xanthans 0.8%
Water surplus
Said components is mixed by formula rate, after high speed shear, obtain the phonetic phenol suspending agent of 21% Fluoxastrobin second.
The phonetic phenol suspending agent of embodiment 2:6% Fluoxastrobin second comprises following component by weight:
Fluoxastrobin 5%
The phonetic phenol 1% of second
Alkylaryl polyoxyethylene polyoxypropylene ether 5%
Poly-naphthaldehyde sulfonate sodium 4%
Ethylene glycol 2.5%
Xanthans 0.8%
Water surplus
Said components is mixed by formula rate, after high speed shear, obtain the phonetic phenol suspending agent of 6% Fluoxastrobin second.
Embodiment 3:15% Fluoxastrobin ethirimol water dispersible granules comprises following component by weight:
Fluoxastrobin 7.5%
The phonetic phenol 7.5% of second
Sodium lignin sulfonate 6%
PO-EO block polyether 4%
Lauryl sodium sulfate 3%
Ammonium sulfate 5%
The precipitated calcium carbonate surplus
Above-mentioned active component, dispersant, wetting agent, disintegrant and the filler ratio in prescription is mixed, become wetting powder through comminution by gas stream, add a certain amount of water mixing extruder grain again, obtain 15% Fluoxastrobin ethirimol water dispersible granules after the drying screening.
Embodiment 4:12% Fluoxastrobin bupirimate water dispersible granules comprises following component by weight:
Fluoxastrobin 2%
Bupirimate 10%
Sodium lignin sulfonate 6%
PO-EO block polyether 4%
Lauryl sodium sulfate 3%
Ammonium sulfate 4.5%
The precipitated calcium carbonate surplus
Above-mentioned active component, dispersant, wetting agent, disintegrant and the filler ratio in prescription is mixed, become wetting powder through comminution by gas stream, add a certain amount of water mixing extruder grain again, obtain 12% Fluoxastrobin bupirimate water dispersible granules after the drying screening.
Embodiment 5:63% Fluoxastrobin bupirimate wetting powder comprises following component by weight:
Fluoxastrobin 3%
Bupirimate 60%
To methoxyl group fatty acid Sodium p-aminobenzene sulfonat 1%
Sodium methylene bis-naphthalene sulfonate 2%
White carbon 2.5%
The kaolin surplus
Said components is mixed into promoting the circulation of qi stream pulverizes, make 63% Fluoxastrobin bupirimate wetting powder.
The phonetic phenol bupirimate of embodiment 6:63% Fluoxastrobin second wetting powder comprises following component by weight:
Fluoxastrobin 3%
The phonetic phenol 30% of second
Bupirimate 30%
To methoxyl group fatty acid Sodium p-aminobenzene sulfonat 1%
Sodium methylene bis-naphthalene sulfonate 2%
White carbon 2.5%
The kaolin surplus
Said components is mixed into promoting the circulation of qi stream pulverizes, make the phonetic phenol bupirimate of 63% Fluoxastrobin second wetting powder.
Test example: the test of pesticide effectiveness of the medicament of the foregoing description being tested the control grape powdery mildew
Several mixtures that the embodiment of the invention is obtained carry out the test of pesticide effectiveness, adopt greenhouse cuttage grape seedling, measure Fluoxastrobin and phonetic phenol or/and single mixture of bupirimate to the control efficiency of grape powdery mildew.When grape seedling grows to 3～4 leaves, select the blade of growing way uniformity to adopt manual sprayer to carry out the foliar spray processing, inoculate pathogen after 24 hours, preserve moisture and cultivate 7d " Invest, Then Investigate " result, the results are shown in Table 2.
The phonetic phenol of table 2 Fluoxastrobin and second, bupirimate list mixture are to the control efficiency of grape powdery mildew
| Reagent agent | Extension rate | Disease index | Control efficiency (%) |
| Embodiment 1 product | ??1000 | ??20.91 | ??72.56 |
| Embodiment 2 products | ??1000 | ??17.86 | ??76.56 |
| Embodiment 3 products | ??1000 | ??18.06 | ??76.30 |
| Embodiment 4 products | ??1000 | ??15.23 | ??80.01 |
| Embodiment 5 products | ??1000 | ??19.96 | ??73.80 |
| Embodiment 6 products | ??1000 | ??18.96 | ??75.12 |
| 20% Fluoxastrobin SC | ??1000 | ??23.1 | ??69.68 |
| The phonetic phenol SC of 20% second | ??1000 | ??24.62 | ??67.69 |
| 20% bupirimate SC | ??1000 | ??23.82 | ??68.74 |
| The clear water contrast | ??- | ??76.21 | ??- |
As can be seen from Table 2, the phonetic phenol of Fluoxastrobin and second be or/and the mixture preparation of bupirimate can effectively be prevented and treated grape powdery mildew, and is better than the control efficiency of single agent, significant difference.
As can be seen from the above embodiments, the composition of phonetic phenol of Fluoxastrobin of the present invention and second or bupirimate has good control efficiency to agriculture powdery mildew, thereby reduced the medicament usage amount, when reducing drug cost, reduced influence degree environment.
Claims (5)
1. bactericidal composition that is used to prevent and treat powdery mildew, its active ingredient comprises Fluoxastrobin and miazines bactericide, the weight ratio of the two is Fluoxastrobin: miazines bactericide=20: 1～1: 20.
2. the bactericidal composition that is used to prevent and treat powdery mildew according to claim 1 is characterized in that, described Fluoxastrobin and miazines bactericide weight ratio are Fluoxastrobin: miazines bactericide=5: 1～1: 5.
3. the bactericidal composition that is used to prevent and treat powdery mildew according to claim 1 and 2 is characterized in that, described miazines bactericide is that the phonetic phenol of second is or/and bupirimate.
4. the bactericidal composition that is used to prevent and treat powdery mildew according to claim 1 and 2 is characterized in that, the weight percentage of described active ingredient is 1%～80%.
5. the bactericidal composition that is used to prevent and treat powdery mildew according to claim 1 is characterized in that the formulation of said composition comprises wetting powder, suspending agent or water dispersible granules.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101731223A (en) * | 2010-02-25 | 2010-06-16 | 北京颖泰嘉和科技股份有限公司 | Fungicide composition containing azoxystrobin and ethirimol, and application thereof |
| CN102308825A (en) * | 2011-10-13 | 2012-01-11 | 海利尔药业集团股份有限公司 | Germicide composition in combination with bupirimate |
| CN102113486B (en) * | 2010-01-03 | 2013-04-24 | 青岛奥迪斯生物科技有限公司 | Bactericidal composition containing ethirimol and azoxystrobin |
| CN105265494A (en) * | 2014-06-27 | 2016-01-27 | 陕西美邦农药有限公司 | Highly-efficient bactericidal composition containing polygonum cuspidatum extract |
| CN105475286A (en) * | 2015-12-24 | 2016-04-13 | 皓程瑞通（北京）科技发展有限公司 | Agricultural bactericidal composition containing bupirimate and azoxystrobin |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101595883A (en) * | 2009-05-07 | 2009-12-09 | 深圳诺普信农化股份有限公司 | A kind of composition pesticide and application thereof |
-
2009
- 2009-11-30 CN CN 200910310640 patent/CN101700016B/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102113486B (en) * | 2010-01-03 | 2013-04-24 | 青岛奥迪斯生物科技有限公司 | Bactericidal composition containing ethirimol and azoxystrobin |
| CN101731223A (en) * | 2010-02-25 | 2010-06-16 | 北京颖泰嘉和科技股份有限公司 | Fungicide composition containing azoxystrobin and ethirimol, and application thereof |
| CN102308825A (en) * | 2011-10-13 | 2012-01-11 | 海利尔药业集团股份有限公司 | Germicide composition in combination with bupirimate |
| CN105265494A (en) * | 2014-06-27 | 2016-01-27 | 陕西美邦农药有限公司 | Highly-efficient bactericidal composition containing polygonum cuspidatum extract |
| CN105475286A (en) * | 2015-12-24 | 2016-04-13 | 皓程瑞通（北京）科技发展有限公司 | Agricultural bactericidal composition containing bupirimate and azoxystrobin |
| CN105475286B (en) * | 2015-12-24 | 2018-05-04 | 北京中林佳诚科技有限公司 | A kind of agricultural bactericidal composition containing bupirimate and Fluoxastrobin |
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| CN101700016B (en) | 2013-04-17 |
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Address after: 266228 Qingdao City, Shandong province Laixi City, Jiang Shan town before the village (Busan Industrial Park) Applicant after: Qingdao Star Cropscience Co., Ltd. Address before: 266071, room 4, building 133, Ting capital building, No. 312, Fuzhou North Road, Qingdao, Shandong Applicant before: Qingdao Star Cropscience Co., Ltd. |
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