CN104351254B - A kind of containing Nikemycin with the bactericidal composition of Fluoxastrobin - Google Patents
A kind of containing Nikemycin with the bactericidal composition of Fluoxastrobin Download PDFInfo
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- CN104351254B CN104351254B CN201410596417.9A CN201410596417A CN104351254B CN 104351254 B CN104351254 B CN 104351254B CN 201410596417 A CN201410596417 A CN 201410596417A CN 104351254 B CN104351254 B CN 104351254B
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- nikemycin
- fluoxastrobin
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Abstract
The present invention relates to a kind of containing Nikemycin with the bactericidal composition of Fluoxastrobin, its active component is Nikemycin and Fluoxastrobin, wherein Nikemycin and Fluoxastrobin weight ratio are 1:40 5:1, the gross weight percentage composition of two kinds of active components is 2 80%, and remaining is to allow in pesticide to use and acceptable composition.This bactericidal composition has obvious potentiation, and compared with single dose, preventive effect improves, and dosage reduces, and reduces cost and the pollution to environment.
Description
Technical field
The invention belongs to technical field of pesticide, be specifically related to a kind of containing Nikemycin with the bactericidal composition of Fluoxastrobin.
Background technology
Nikemycin is the streptomyces ansochromogenes that Institute of Microorganism, Academia Sinica is separated to from the soil of northeast
7100 metabolite produced, belong to broad spectrum activity biogenic antibacterial, have preventive and therapeutic action concurrently.Nikemycin is to fungal cell
In wall and insecticide shell, chitin synthesis is inhibited, has good selective toxicity, non-to the toxicity of mammal
The lowest.This medicine has preferable prevention effect to multiple fungal plant disease, insecticide and acarid, belongs to efficient, low toxicity, low-residual
Pesticide, to plant without poisoning, to natural enemies security.
Nikemycin is used alone and easily makes pathogenic bacteria develop immunity to drugs, and is compounded by different cultivars, can be the most anti-
Bacterium Drug resistance of curing the disease produces.Complex preparation product currently, with respect to Nikemycin is less, it is impossible to meets and produces the anti-of upper disease
Control.
The present invention utilizes existing pesticide species resource, is studied, find Nikemycin and azoxystrobin compound to kind
Folium Solani Melongenae mildew has significant preventive effect.
Fluoxastrobin is a kind of methoxy acrylic bactericide, has protection, treats and root out triple role, has good
Good crop safety and prominent Environmental compatibility.Fluoxastrobin can suppress pathogen mitochondrial respiratory.Nikemycin can suppress
The chitinous synthesis of fungal cell wall.Both mechanism of action is entirely different, can act in sites many to pathogenic bacteria, it is easier to shovel after compounding
Except resistance pathogenic bacteria, delay the generation of pathogenic bacteria resistance.
Summary of the invention
It is an object of the invention to provide that a kind of preventive effect is good, low cost, the pathogenic bacteria resistance that can delay produce containing Nikemycin and
The bactericidal composition of Fluoxastrobin.
It is an object of the invention to be achieved through the following technical solutions:
A kind of containing Nikemycin with the bactericidal composition of Fluoxastrobin, its active component is Nikemycin and Fluoxastrobin, wherein
Nikemycin and Fluoxastrobin weight ratio are 1:40-5:1, and the gross weight percentage composition of two kinds of active components is 2-80%, and remaining is agriculture
Medicine allows use and acceptable composition.
The bactericidal composition of the present invention can make any one dosage form of applicable agricultural use, and preferred dosage form is wettable
Property powder, water preparation and water dispersible granules.
Preferably, the bactericidal composition of the present invention also include auxiliary agent, described auxiliary agent include emulsifying agent, dispersant, wetting agent,
Disintegrating agent, binding agent etc. are all conventional in pesticidal preparations or allow to use, and concrete auxiliary agent and consumption are true according to recipe requirements
Fixed.
Preferably, the weight ratio of described active component Nikemycin and Fluoxastrobin is 1:10-1:1, more preferably 1:2.
Preferably, in described bactericidal composition, the gross weight percentage composition of active component is 2-60%；More preferably 12%.
Microbicide compositions of the present invention is applicable to prevent and treat Cereal, each planting fruit-trees, vegetable crop disease, such as Semen Tritici aestivi white lead
Disease, rice blast, Glomerella cingulata, leaf muld of tomato, powdery mildew of strawberry, gray mold of cucumber etc., especially prevent and treat tomato leaf
Mildew.
The bactericidal composition of the present invention can be prepared by the conventional method of prior art, compared to prior art,
There is following beneficial effect:
1. this bactericidal composition has obvious potentiation, and compared with single dose, preventive effect improves, and dosage reduces, and reduces
Cost and the pollution to environment.
2. the effective ingredient mixture of two kinds of different mechanism of action, mutual synergism, achieves the technique effect of excellence, has
It is beneficial to delay the Drug resistance of pathogenic bacteria.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, the present invention is for implementing in detail below
Example illustrates, but the present invention is limited to absolutely not these examples.
Toxicity measures embodiment: Nikemycin and azoxystrobin compound are to leaf muld of tomato Toxicity Determination
Subjects: Fulvia fulva, gathers diseased plant from the tomato greenhouse booth of emerging town, Pucheng County, carries out tissue point
From, single spore separation.
Test method: use growth rate method.The pathogenic bacteria that will be enlarged by cultivating 7 days breaks into the bacterium cake of a diameter of 0.6cm, in nothing
Under the conditions of bacterium, being placed in the PDA culture medium flat plate central authorities containing different agents concentration, each process is repeated 3 times, with not adding medicine
The bacterium cultivated in PDA culture medium is comparison.After being placed in 25 DEG C of constant incubators cultivations 5 days, measure bacterium colony by decussation method straight
Footpath, calculates inhibition percentage, obtains virulence regression equation and the EC of each medicament50。
Toxicity index and the co-toxicity coefficient (CTC) of medicament is calculated according to the abundant method of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) × 100
Percentage composition+B medicament toxicity index x the mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture
The percentage composition of middle B
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theory toxicity index (TTI) × 100
When CTC≤80, then compositions shows as Hangzhoupro short of money effect, and when 80 < CTC < 120, then compositions shows as summation action,
When CTC >=120, then compositions shows as potentiation.
Result of the test: Toxicity Determination result see table 1:
Table 1 Nikemycin and the azoxystrobin compound Toxicity Determination result to leaf muld of tomato
As can be seen from Table 1, Nikemycin and Fluoxastrobin between proportioning 1:40-5:1, co-toxicity coefficient be more than 120, to kind
Folium Solani Melongenae mildew has potentiation.Wherein proportioning is between 1:10-1:1, and co-toxicity coefficient is more than 200, and potentiation is the most notable.
Specify that Nikemycin has good potentiation work with Fluoxastrobin so that certain proportion is compounding by indoor biometrics test
With, further illustrate the present invention below by way of pharmaceutical formulation embodiment, but the present invention is only limitted to absolutely not following embodiment.
Pharmaceutical formulation embodiment
Embodiment 1:2% Nikemycin Fluoxastrobin suspending agent
Ingredient names percentage by weight
Nikemycin (effective ingredient) 1%
Fluoxastrobin (effective ingredient) 1%
Naphthalenesulfonic acid-formaldehyde condensate (dispersant) 8%
Dodecyl sodium sulfate (wetting agent) 3%
Xanthan gum (thickening agent) 2%
Glycerol (antifreeze) 5%
Polyoxyethylene polyoxypropylene glycerin ether (defoamer) 2%
Water complements to 100%
By each components such as active component, dispersant, wetting agent, thickening agent, antifreeze, defoamer and water in the ratio of formula
Mix homogeneously, it is broken to add sand mill medium sand pulverizing, then obtains 2% Nikemycin Fluoxastrobin after putting in homogenizing still mixing and suspend
Agent.
Embodiment 2:60% Nikemycin Fluoxastrobin wettable powder
Ingredient names percentage by weight
Nikemycin (effective ingredient) 50%
Fluoxastrobin (effective ingredient) 10%
Sodium lauryl sulphate (wetting agent) 3%
Sodium lignin sulfonate (dispersant) 4%
White Carbon black (filler) 10%
Kaolin (filler) complements to 100%
Effective ingredient, auxiliary agent and filler etc. are sufficiently mixed in the ratio of formula, remix after comminution by gas stream and get final product
60% Nikemycin Fluoxastrobin wettable powder.
Embodiment 3:80% Nikemycin Fluoxastrobin suspending agent
Ingredient names percentage by weight
Nikemycin (effective ingredient) 10%
Fluoxastrobin (effective ingredient) 70%
Naphthalenesulfonic acid-formaldehyde condensate (dispersant) 8%
Dodecyl sodium sulfate (wetting agent) 3%
Xanthan gum (thickening agent) 2%
Glycerol (antifreeze) 5%
Polyoxyethylene polyoxypropylene glycerin ether (defoamer) 2%
Water complements to 100%
By each components such as active component, dispersant, wetting agent, thickening agent, antifreeze, defoamer and water in the ratio of formula
Mix homogeneously, it is broken to add sand mill medium sand pulverizing, then obtains 80% Nikemycin Fluoxastrobin after putting in homogenizing still mixing and hang
Floating agent.
Embodiment 4:12% Nikemycin azoxystrobin water dispersible granule
Ingredient names percentage by weight
Nikemycin (effective ingredient) 4%
Fluoxastrobin (effective ingredient) 8%
Sodium lauryl sulphate (wetting agent) 5%
Sodium lignin sulfonate (dispersant) 6%
Ammonium sulfate (disintegrating agent) 5%
Starch (binding agent) 2%
Precipitated calcium carbonate (filler) complements to 100%
By effective ingredient, auxiliary agent and filler in the ratio mix homogeneously of formula, become wettable powder through comminution by gas stream, then add
Enter a certain amount of water mixing extruder grain, after drying screening, obtain 12% Nikemycin azoxystrobin water dispersible granule.
Embodiment 5:22% Nikemycin Fluoxastrobin wettable powder
Ingredient names percentage by weight
Nikemycin (effective ingredient) 2%
Fluoxastrobin (effective ingredient) 20%
Sodium lauryl sulphate (wetting agent) 3%
Sodium lignin sulfonate (dispersant) 5%
White Carbon black (filler) 9%
Kaolin (filler) complements to 100%
Effective ingredient, auxiliary agent and filler etc. are sufficiently mixed in the ratio of formula, remix after comminution by gas stream and i.e. obtain 22%
Nikemycin Fluoxastrobin wettable powder.
Embodiment 6:41% Nikemycin azoxystrobin water dispersible granule
Ingredient names percentage by weight
Nikemycin (effective ingredient) 1%
Fluoxastrobin (effective ingredient) 40%
Sodium lauryl sulphate (wetting agent) 5%
Sodium lignin sulfonate (dispersant) 6%
Ammonium sulfate (disintegrating agent) 5%
Starch (binding agent) 2%
Precipitated calcium carbonate (filler) complements to 100%
By effective ingredient, auxiliary agent and filler in the ratio mix homogeneously of formula, become wettable powder through comminution by gas stream, then add
Enter a certain amount of water mixing extruder grain, after drying screening, obtain 41% Nikemycin azoxystrobin water dispersible granule.
Above example is selected to carry out preventing and treating the field control effectiveness test of leaf muld of tomato, by resisting with single dose pyridimine nucleosides
Rhzomorph and the Contrast on effect of Ningnanmycin, the potentiation after checking is compounding.
Field efficacy embodiment: Nikemycin and Fluoxastrobin series complex preparation prevent and treat the examination of leaf muld of tomato field efficacy
Test.
Test method: be experimental field located in Fructus Lycopersici esculenti booth field, emerging town, Pucheng County, Shaanxi Province, after tomato seedling is fallen ill, respectively
Spraying treatment is carried out, to spray clear water as blank with each medicament.Each process is repeated 3 times, dispenser in each 7 days once, continuous 2
Secondary, 7 days " Invest, Then Investigate " state of an illness of dispenser for the second time, in units of blade, record severity.Calculate disease index and prevention effect.
The grade scale of disease is: 0 grade: blade is without scab；1 grade: lesion area accounts for less than the 10% of blade area；2 grades: lesion area
Account for the 10-30% of blade area；3 grades: lesion area accounts for the 30-50% of blade area；4 grades: lesion area accounts for the 50% of blade area
Up to fall leaves.
Result of the test: above-mentioned formulation Example is prevented and treated the field control effectiveness test of leaf muld of tomato and be the results are shown in Table 2
From table 2 it can be seen that the preventive effect of leaf muld of tomato is compareed by the bactericidal composition of the present invention apparently higher than single dose,
Low is 85.58%, is up to 94.35%.Particularly Nikemycin and Fluoxastrobin proportioning are at 1:10-1:1, and preventive effect is more notable, reaches
More than 90%, it is seen that Nikemycin and azoxystrobin compound have potentiation.
Dosage and drug cost embodiment
Table 3 dosage and drug cost
From table 3 it can be seen that Nikemycin uses with azoxystrobin compound can reduce dosage, thus reduce cost, subtract
The light pollution to environment.
Although by referring to the preferred embodiments of the present invention, invention has been described, but this area is common
It will be appreciated by the skilled person that in the form and details various change can be made for it, without departing from appended right
The spirit and scope of the present invention that claim is limited.
Claims (5)
1., containing Nikemycin and a bactericidal composition for Fluoxastrobin, its active component is Nikemycin and Fluoxastrobin, Qi Zhongni
Can mycin and Fluoxastrobin weight ratio be 1:2, the gross weight percentage composition of two kinds of active components be 12%, and remaining is to allow in pesticide
Use and acceptable composition.
Bactericidal composition the most according to claim 1, it is characterised in that make applicable agricultural use wettable powder,
Water preparation or water dispersible granules.
Bactericidal composition the most according to claim 1, it is characterised in that described bactericidal composition also includes auxiliary agent, described
Auxiliary agent includes emulsifying agent, dispersant, wetting agent, disintegrating agent, binding agent.
4. the microbicide compositions described in claim any one of claim 1-3 is preventing and treating Cereal, each planting fruit-trees, vegetable
Application in crop pest.
Application the most according to claim 4, it is characterised in that described disease includes wheat powdery mildew, rice blast, Herba Marsileae Quadrifoliae
Really zonate spot, leaf muld of tomato, powdery mildew of strawberry, gray mold of cucumber.
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| CN201410596417.9A CN104351254B (en) | 2014-10-30 | 2014-10-30 | A kind of containing Nikemycin with the bactericidal composition of Fluoxastrobin |
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| CN201410596417.9A CN104351254B (en) | 2014-10-30 | 2014-10-30 | A kind of containing Nikemycin with the bactericidal composition of Fluoxastrobin |
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| CN106259462B (en) * | 2015-05-11 | 2019-06-07 | 牡丹江佰佳信生物科技有限公司 | A kind of bactericidal composition and its application |
| CN105028484B (en) * | 2015-05-27 | 2017-12-05 | 邓全芳 | The bactericidal composition and its preparation of a kind of hymexazol of frost containing first and Nikemycin |
| CN104886155B (en) * | 2015-05-27 | 2017-11-07 | 邓全芳 | The bactericidal composition and its preparation of a kind of pyrimethanil-contain bactericide and Nikemycin |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102067851A (en) * | 2011-01-20 | 2011-05-25 | 陕西美邦农药有限公司 | Antibacterial composition containing polyoxin and methoxyacrylate compound |
| CN102239862A (en) * | 2011-05-27 | 2011-11-16 | 江苏省绿盾植保农药实验有限公司 | Compound bactericide of azoxystrobin and polyoxin |
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2014
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102067851A (en) * | 2011-01-20 | 2011-05-25 | 陕西美邦农药有限公司 | Antibacterial composition containing polyoxin and methoxyacrylate compound |
| CN102239862A (en) * | 2011-05-27 | 2011-11-16 | 江苏省绿盾植保农药实验有限公司 | Compound bactericide of azoxystrobin and polyoxin |
Non-Patent Citations (1)
| Title |
|---|
| 多氧霉素与尼可霉素的代谢工程与组合生物合成研究;翟李鹏;《上海交通大学硕士学位论文》;20120531;第16-26页 * |
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Address after: 715511 Pucheng County Industrial Park, Shaanxi Province Applicant after: SHAANXI MICROBE BIO-TECHNOLOGY CO., LTD. Address before: In 715500 Weinan city of Shaanxi Province, Pucheng County Road No. 27 Applicant before: Shaanxi Lvdun Biological Products Co., Ltd. |
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