CN101491582A - Combination with blood sugar reducing function and preparation method thereof - Google Patents
Combination with blood sugar reducing function and preparation method thereof Download PDFInfo
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- CN101491582A CN101491582A CNA2008100567011A CN200810056701A CN101491582A CN 101491582 A CN101491582 A CN 101491582A CN A2008100567011 A CNA2008100567011 A CN A2008100567011A CN 200810056701 A CN200810056701 A CN 200810056701A CN 101491582 A CN101491582 A CN 101491582A
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- caulis opuntiae
- opuntiae dillenii
- radix
- extract
- psidii guajavae
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Abstract
The invention discloses a composition with the function of reducing blood sugar and a preparation method thereof. The composition is prepared from fresh cactus, guava leaf and glucose chromic acid according to certain weight proportion. The composition can be prepared into any common preparation formulation. The composition of the invention has the efficacy of reducing blood sugar, and can be used for treating diabetes.
Description
Technical field
The present invention relates to a kind of composition and method of making the same, belong to medicine and field of health care food with function of blood sugar reduction.
Background technology
Diabetes are the one group of Developmental and Metabolic Disorder syndromes that is caused by the h and E factor interaction.Long-term diabetes can cause the chronic complicating diseases of a plurality of systems organ, cause dysfunction and depletion, become disable, lethal main cause.At present, the prevalence of diabetes had the trend of remarkable rising in recent years in the population of China.Because the cause of disease and the pathogenesis of diabetes are not clear fully as yet, therefore also lack effective etiological treatment method at present.Clinically treatment of diabetes is adopted insulinize and oral hypoglycemic drug therapy more now, yet diabetes spp is in a kind of lifelong participation disease, need long-term prescription, the drug administration by injection method of insulin tends to bring many inconvenience to the patient, and clinical orally-taken blood sugar reducing medicine commonly used belongs to chemical drugs more, takes for a long time also and can cause a series of untoward reaction.In view of there being above problem, so exploitation a kind of blood sugar lowering medicine and health food safe, effective, that be suitable for taking for a long time are badly in need of on present market very much.
Summary of the invention
The object of the invention just provides a kind of compositions with function of blood sugar reduction.
Another object of the present invention has provided the preparation method of said composition.
The present invention is achieved by the following technical solutions:
The present invention is made by the following weight proportion raw material:
Fresh Radix et Caulis Opuntiae Dillenii 5-20 part, Folium Psidii Guajavae 1-10 part, chromium gluconate 0.001-0.009 part.
Be preferably:
10 parts of fresh Radix et Caulis Opuntiae Dillenii, 3 parts of Folium Psidii Guajavae, 0.006 part of chromium gluconate.
The preparation method of the present composition is as follows:
With new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process, filter, get filtrate, use ethanol precipitation, centrifugal, taking precipitate, washing with alcohol, lyophilization is pulverized, and gets Radix et Caulis Opuntiae Dillenii crude polysaccharides extract; Folium Psidii Guajavae water or different concentration ethanol are extracted, get Folium Psidii Guajavae extract; With Radix et Caulis Opuntiae Dillenii extract or Radix et Caulis Opuntiae Dillenii crude polysaccharides extract, the Folium Psidii Guajavae extract mix homogeneously, add chromium gluconate, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, teabag, oral liquid etc.
The preferred for preparation method of the present composition is as follows:
With new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract; With Radix et Caulis Opuntiae Dillenii extract or Radix et Caulis Opuntiae Dillenii crude polysaccharides extract, the Folium Psidii Guajavae extract mix homogeneously, add chromium gluconate, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, teabag, oral liquid etc.
Wherein, described Radix et Caulis Opuntiae Dillenii extract or Radix et Caulis Opuntiae Dillenii crude polysaccharides extract can also outsourcings.
Drug mechanism of the present invention is as follows:
Radix et Caulis Opuntiae Dillenii: Radix et Caulis Opuntiae Dillenii bitter in the mouth cold in nature has the effect of detoxifcation analgesia, detumescence and apocenosis, promoting flow of QI and blood.Pharmacological research shows that Radix et Caulis Opuntiae Dillenii has the obvious functions of blood sugar effect, can improve type ii diabetes patient's carbohydrate metabolism effectively.On Mexico, the U.S. and other places, Radix et Caulis Opuntiae Dillenii is used to treat diseases such as diabetes, ulcer, has been made into various tablets and soft gelatin capsule.In China, the Radix et Caulis Opuntiae Dillenii compound preparation also is used for treating diabetes.In the test that the alloxan diabetes model that with Wistar is animal pattern foundation carries out, find; The extract of Radix et Caulis Opuntiae Dillenii does not have obvious influence to normal rat blood sugar, but can significantly reduce the blood glucose of model induced by alloxan diabetes rat, and its blood sugar reducing function is relevant with dosage.Its high dose can also significantly reduce diabetes rat 24h urine amount.Simultaneously, induce at streptozotocin (STZ) on the rat diabetes model basis of foundation, Radix et Caulis Opuntiae Dillenii juice is used for the treatment of the disease Mus.The result shows that it is normal that its glucose amount of the diabetic mice of administration group and serum insulin levels are recovered, and matched group is still unusual, shows that the Radix et Caulis Opuntiae Dillenii extract has the effect for the treatment of diabetes, improving insulin resistant.
Folium Psidii Guajavae: sweet, puckery, flat.Function: astringing to arrest diarrhea, anti-inflammation hemostasia.Leaf, really: acute and chronic enteritis, dysentery, infantile dyspepsia; Bright leaf: traumatic injury is controlled in external, traumatic hemorrhage, ecthyma disunion of a specified duration.Recent study finds that Fructus psidii guajavae immaturus has good blood sugar lowering, effect for reducing fat, and Folium Psidii Guajavae is to have the sensitivity that improves Insulin receptor INSR, thereby has the effect of blood sugar lowering.It (is the B cell of alloxan damage pancreas islets of langerhans that this experiment is made diabetes model with the tail vein injection alloxan, cause insulin secretion to reduce, blood sugar increasing), different extract for treating with Folium Psidii Guajavae, the result shows that the treatment group has the obvious functions of blood sugar effect than model control group, and ethanol extract treatment group acts on the most obvious in three groups of treatment groups, thereby verified that not only Folium Psidii Guajavae has hypoglycemic activity very doughtily, and the foundation of science is provided for the exploitation of its effective ingredient.
Chromium gluconate: chromium (Cr) is as a kind of trace element, found first by french chemist Wo Kuilin in 1797.Scientists confirms afterwards, and chromium is the important component part of glucose tolerance factor, is decided to be micro elements needed by human in 1989.Chrome content is very little among the normal human, and whole body content is the 6-7 milligram, but is bringing into play important physiological function, comprise saccharide and lipometabolic adjusting, the integrity of keeping nucleic acid structure and stability, and to the influence of some enzymatic activity.Wherein, with diabetes closely-related be chromium as the glucose tolerance factor ingredient, assist insulin to play a role, regulate carbohydrate metabolism, keep normal carbohydrate tolerance in the body.Domestic and international a plurality of clinical experiment is found, by replenishing chromium, can significantly improve symptoms such as diabetes patient's excessive thirst, polyuria, makes blood glucose steady, reduces the glycolated hemoglobin value.Chromium has six kinds of quantivalences, and trivalent chromium wherein has the effect of indirect regulation blood glucose, and the chemical property stabilizer pole is all as safe as a house to people and animal.
In the present composition, Radix et Caulis Opuntiae Dillenii has the effect of detoxifcation analgesia, detumescence and apocenosis, can effectively discharge the intravital toxin of diabetes patient; Folium Psidii Guajavae has the effect of antiinflammatory, can prevent and treat diabetic complication; Chromium gluconate can significantly improve symptoms such as diabetes patient's excessive thirst, polyuria, makes blood glucose steady; Three medicines are harmonious and fundamentally regulate diabetes patient's body comprehensively, improve diabetes patient's physical condition, and three flavor medicines all have very clear and definite blood sugar lowering pharmacology effect, can be with diabetes patient's blood glucose regulation to normal level.
In sum, the present composition has the effect of detoxifcation analgesia, detumescence and apocenosis, additional multiple beneficial element.Can be used for prevention and treatment diabetes.
The present invention with respect to prior art have determined curative effect, have no side effect, taking convenience, cheap advantage.
Further set forth the beneficial effect of compositions of the present invention by following experiment.
1 materials and methods
1.1 experiment material:
Experimental subject: 40 of Wistar rats, male and female half and half, body weight 160 ± 20g.
Experimental drug: present composition extract, alloxan, glucose oxidase enzyme reagent kit.
Experiment equipment: 4 of spectrophotometer standard cuvettes, one on rat oral gavage pin, corresponding No. 4, No. 5 syringe needles of 5ml syringe, test tube, dropper, pipet, scalpel.
1.2 experimental technique:
Modelling: with getting 30 rats (male and female half and half), by 250mg/kg lumbar injection alloxan (being dissolved in aseptic injection water).2 survey blood glucose before and after modeling are defined as whole modelings successes.
The experiment grouping: modeling success rat is divided into three groups (male and female half and half) at random, and remaining rat is one group:
First group: normal blank group; Every day normal diet.
Second group: not administration of Cheng Mo group; Every day, normal saline was irritated stomach, normal diet.
The 3rd group: become mould low dosage administration group; Press the 100mg/kg body weight every day and irritate stomach, normal diet with present composition extract.
The 4th group: become mould high dose administration group; Press the 200mg/kg body weight every day and irritate stomach, normal diet with present composition extract.
1.3 experimental index: laboratory animal tail point is got blood, surveys concentration of glucose in the blood.
1.4 date processing: (x ± s) expression, relatively check with t in the group by data with means standard deviation for each index.
2 results: see Table 1
The statistical value of each experimental group of table 1
Compare * P＜0.05 with matched group, * * P＜0.01
The result shows, low dose therapy group of the present invention compares with matched group that there were significant differences (* P＜0.05), high-dose therapy group of the present invention is compared the difference (* * P＜0.01) that highly significant is arranged with matched group, illustrate that the present composition has clear and definite hypoglycemic effect.
The specific embodiment
Embodiment 1:
The preparation of the capsule of the present composition
A) take by weighing fresh Radix et Caulis Opuntiae Dillenii 10kg, Folium Psidii Guajavae 3kg, chromium gluconate 0.006kg;
B) with new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract;
C), add chromium gluconate, drying, the snap fit capsule of packing into said extracted thing mix homogeneously.
Embodiment 2:
The preparation of the granule of the present composition
A) take by weighing fresh Radix et Caulis Opuntiae Dillenii 5kg, Folium Psidii Guajavae 1kg, chromium gluconate 0.003kg;
B) with new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract;
C) with said extracted thing mix homogeneously, be ground into powder, add chromium gluconate, mix homogeneously adds ethanol and makes adhesive, adds appropriate amount of starch and makes filler, makes granule.
Embodiment 3:
The preparation of the granule of the present composition
A) take by weighing fresh Radix et Caulis Opuntiae Dillenii 20kg, Folium Psidii Guajavae 10kg, chromium gluconate 0.009kg;
B) with new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract;
C) with said extracted thing mix homogeneously, be ground into powder, add chromium gluconate, mix homogeneously adds ethanol and makes adhesive, adds appropriate amount of starch and makes filler, makes granule.
Embodiment 4:
The preparation of the tablet of the present composition
A) take by weighing fresh Radix et Caulis Opuntiae Dillenii 5kg, Folium Psidii Guajavae 3kg, chromium gluconate 0.005kg;
B) with new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract;
C) with said extracted thing mix homogeneously, be ground into powder, add chromium gluconate, mix homogeneously adds adjuvant and makes granule, and dry, and compacting in flakes.
Embodiment 5:
The preparation of the tablet of the present composition
A) take by weighing fresh Radix et Caulis Opuntiae Dillenii 5kg, Folium Psidii Guajavae 3kg, chromium gluconate 0.006kg;
B) with new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; Folium Psidii Guajavae is extracted with 10 times of amounts and 8 times of water gagings, and each 1 hour, merge extractive liquid, filtered, concentrating under reduced pressure, and drying is pulverized, and gets Folium Psidii Guajavae extract;
C) with said extracted thing mix homogeneously, be ground into powder, add chromium gluconate, mix homogeneously adds adjuvant and makes granule, and dry, and compacting in flakes.
Embodiment 6:
The preparation of the effervescent tablet of the present composition
A) take by weighing fresh Radix et Caulis Opuntiae Dillenii 10kg, Folium Psidii Guajavae 5kg, chromium gluconate 0.002kg;
B) with new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying is pulverized, and obtains the Radix et Caulis Opuntiae Dillenii extract, or, clean cutting, oven dry with new fresh Radix et Caulis Opuntiae Dillenii, pulverize, soak pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract;
C) with said extracted thing mix homogeneously, be ground into powder, add chromium gluconate, mix homogeneously adds tartaric acid, sodium bicarbonate, sweeting agent, filler mixing, granulates with dehydrated alcohol, and drying adds the lubricant mixing, tabletting, promptly.
Claims (5)
1, a kind of compositions with hypoglycemic activity is characterized in that, it is to be made by following bulk drugs: fresh Radix et Caulis Opuntiae Dillenii 5-20 part, Folium Psidii Guajavae 1-10 part, chromium gluconate 0.001-0.009 part.
According to the compositions of claim 1, it is characterized in that 2, it is to be made by following bulk drugs: 10 parts of fresh Radix et Caulis Opuntiae Dillenii, 3 parts of Folium Psidii Guajavae, 0.006 part of chromium gluconate.
3, claim 1 or 2 described preparation of compositions methods is characterized in that this method is: with new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying, pulverize, obtain the Radix et Caulis Opuntiae Dillenii extract, or, clean new fresh Radix et Caulis Opuntiae Dillenii, cutting, oven dry is pulverized, and soaks, pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal, taking precipitate, washing with alcohol, lyophilization is pulverized, and gets Radix et Caulis Opuntiae Dillenii crude polysaccharides extract; Folium Psidii Guajavae water or different concentration ethanol are extracted, get Folium Psidii Guajavae extract; With Radix et Caulis Opuntiae Dillenii extract or Radix et Caulis Opuntiae Dillenii crude polysaccharides extract, the Folium Psidii Guajavae extract mix homogeneously adds chromium gluconate, is prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
4, preparation of compositions method according to claim 3 is characterized in that, it comprises the following steps: new fresh Radix et Caulis Opuntiae Dillenii squeezing extracting juice, drying, pulverize, obtain the Radix et Caulis Opuntiae Dillenii extract, or, clean new fresh Radix et Caulis Opuntiae Dillenii, cutting, oven dry is pulverized, and soaks, pretreatment, supersound process is filtered, and gets filtrate, use ethanol precipitation, centrifugal (4500r/min), taking precipitate, washing with alcohol, lyophilization gets the Radix et Caulis Opuntiae Dillenii crude polysaccharides; With 10 times of amounts and 8 times amount, 70% alcohol reflux, each 1 hour, merge extractive liquid, filtered with Folium Psidii Guajavae, concentrating under reduced pressure, drying is pulverized, Folium Psidii Guajavae extract; With Radix et Caulis Opuntiae Dillenii extract or Radix et Caulis Opuntiae Dillenii crude polysaccharides extract, the Folium Psidii Guajavae extract mix homogeneously adds chromium gluconate, is prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
5, claim 1 or 2 described compositionss are used to prepare prevention and the medicine of treatment diabetes disease or the application of health food.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100567011A CN101491582A (en) | 2008-01-23 | 2008-01-23 | Combination with blood sugar reducing function and preparation method thereof |
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| CNA2008100567011A CN101491582A (en) | 2008-01-23 | 2008-01-23 | Combination with blood sugar reducing function and preparation method thereof |
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| CN101491582A true CN101491582A (en) | 2009-07-29 |
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| CNA2008100567011A Pending CN101491582A (en) | 2008-01-23 | 2008-01-23 | Combination with blood sugar reducing function and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940620A (en) * | 2010-09-14 | 2011-01-12 | 广州市和藤医药研究开发有限公司 | Medicinal composition for treating diabetes mellitus and application thereof |
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2008
- 2008-01-23 CN CNA2008100567011A patent/CN101491582A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940620A (en) * | 2010-09-14 | 2011-01-12 | 广州市和藤医药研究开发有限公司 | Medicinal composition for treating diabetes mellitus and application thereof |
| CN101940620B (en) * | 2010-09-14 | 2012-07-04 | 广州市和藤医药研究开发有限公司 | Medicinal composition for treating diabetes mellitus and application thereof |
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Open date: 20090729 |